Publications by authors named "Zhengguang Sun"

11 Publications

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Nanoplatform based on GSH-responsive mesoporous silica nanoparticles for cancer therapy and mitochondrial targeted imaging.

Mikrochim Acta 2021 Apr 6;188(5):154. Epub 2021 Apr 6.

Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry, Hubei Key Laboratory of Polymer Materials, School of Materials Science & Engineering, Hubei University, Wuhan, 430062, China.

Mitochondria, as the energy factory of most cells, are not only responsible for the generation of adenosine triphosphoric acid (ATP) but also essential targets for therapy and diagnosis of various diseases, especially cancer. The safe and potential nanoplatform which can deliver various therapeutic agents to cancer cells and mitochondrial targeted imaging is urgently required. Herein, Au nanoparticles (AuNPs), mesoporous silica nanoparticles (MSN), cationic ligand (triphenylphosphine (TPP)), doxorubicin (DOX), and carbon nanodots (CDs) were utilized to fabricate mitochondrial targeting drug delivery system (denoted as CDs(DOX)@MSN-TPP@AuNPs). Since AuNPs, as the gatekeepers, can be etched by intracellular glutathione (GSH) via ligand exchange induced etching process, DOX can be released into cells in a GSH-dependent manner which results in the superior GSH-modulated tumor inhibition activity. Moreover, after etching by GSH, the CDs(DOX)@MSN-TPP@AuNPs can serve as promising fluorescent probe (λ = 633 nm, λ = 650 nm) for targeted imaging of mitochondria in living cells with near-infrared fluorescence. The induction of apoptosis derived from the membrane depolarization of mitochondria is the primary anti-tumor route of CDs(DOX)@MSN-TPP@AuNPs. As a kind of GSH-responsive mitochondrial targeting nanoplatform, it holds great promising for effective cancer therapy and mitochondrial targeted imaging. The mitochondrial targeting drug delivery system was fabricated by AuNPs, MSN, TPP, and CDs. The nanoplatform can realize redox-responsive drug delivery and targeted imaging of mitochondria in living cells to improve the therapeutic efficiency and security.
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http://dx.doi.org/10.1007/s00604-021-04810-4DOI Listing
April 2021

Hollow mesoporous MnO-carbon nanodot-based nanoplatform for GSH depletion enhanced chemodynamic therapy, chemotherapy, and normal/cancer cell differentiation.

Mikrochim Acta 2021 Mar 27;188(4):141. Epub 2021 Mar 27.

Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry, Hubei Key Laboratory of Polymer Materials, School of Materials Science & Engineering, Hubei University, Wuhan, 430062, China.

A redox-responsive chemodynamic therapy (CDT)-based theranostic system composed of hollow mesoporous MnO (H-MnO), doxorubicin (DOX), and fluorescent (FL) carbon nanodots (CDs) is reported for the diagnosis and therapy of cancer. In general, since H-MnO can be degraded by intracellular glutathione (GSH) to form Mn with excellent Fenton-like activity to generate highly reactive ·OH, the normal antioxidant defense system can be injured via consumption of GSH. This in turn can potentiate the cytotoxicity of CDT and release DOX. The cancer cells can be eliminated effectively by the nanoplatform via the synergistic effect of chemotherapy and CDT. The FL of CDs can be restored after H-MnO is degraded which blocked the fluorescence resonance energy transfer process between CDs as an energy donor and H-MnO as an FL acceptor. The GSH can be determined by recovery of the FL and limit of detection is 1.30 μM with a linear range of 0.075-0.825 mM. This feature can be utilized to efficiently distinguish cancerous cells from normal ones based on different GSH concentrations in the two types of cells. As a kind of CDT-based theranostic system responsive to GSH, simultaneously diagnostic (normal/cancer cell differentiation) and therapeutic function (chemotherapy and CDT) in a single nanoplatform can be achieved. The redox-responsive chemodynamic therapy (CDT)-based theranostic system is fabricated by H-MnO, DOX, and fluorescent CDs. The nanoplatform can realize simultaneously diagnostic (normal/cancer cell differentiation) and therapeutic function (chemotherapy and CDT) to improve the therapeutic efficiency and security.
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http://dx.doi.org/10.1007/s00604-021-04801-5DOI Listing
March 2021

Enhanced mineralization of reactive brilliant red X-3B by UV driven photocatalytic membrane contact ozonation.

J Hazard Mater 2020 06 31;391:122194. Epub 2020 Jan 31.

State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, 18 Shuangqing Road, Beijing, 100085, China; National Engineering Laboratory for Industrial Wastewater Treatment, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, 18 Shuangqing Road, Beijing, 100085, China; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing, 100049, China. Electronic address:

The partial oxidation on refractory organics in ozonation process and the poor performance of mass transfer between ozone (O) phase and liquid phase by common O distribution techniques inhibit the practical application of O. To overcome these defects, hollow fiber membrane was applied in membrane contact ozonation (MCO)-UV process for the reactive brilliant red X-3B (RBRX-3B) degradation. The efficiency of mass transfer was guaranteed due to the enormous gas/liquid contact area supplied in this bubble-less O transfer process. UV photolysis not only significantly improved the O utilization efficiency but also accelerated the mineralization of RBRX-3B by promoting O to decompose to hydroxyl radicals (OH). When 15 mg/L of O was supplied at flow rate of 0.2 L/min, and a liquid velocity of 0.453 m/s, the chemical oxygen demand (COD) removal and total organic carbon (TOC) removal reached 90 % and 77 %, respectively. The rate constant for TOC removal in the MCO-UV process (7.89 × 10 min) was 3.08 and 6.12 times higher than that in MCO and UV photolysis processes, respectively. Furthermore, the mineralization efficiency (ΔCOD/ΔO = 0.84 mg/mg) and electrical energy per mass (E = 4.7 kW h/kg) were calculated and these results indicated a promising future for the MCO-UV process.
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http://dx.doi.org/10.1016/j.jhazmat.2020.122194DOI Listing
June 2020

Thickness controllable hypercrosslinked porous polymer nanofilm with high CO capture capacity.

J Colloid Interface Sci 2020 Mar 16;563:272-280. Epub 2019 Dec 16.

Key Laboratory of Polymer Material in Hubei Province, Hubei University, Wuhan 430062, China; Key Laboratory of Green Preparation and Application for Functional Materials, Ministry of Education, Hubei University, Wuhan 430062, China. Electronic address:

Thickness controllable porous polymer nanofilm with superior gas storage capacity has gradually emerged as promising adsorbents for capture of CO, due to extremely high surface area and micro-scale pore. In this work, we have developed a novel and facile strategy to fabricate thickness controllable two or three dimensional ordered porous nanofilm based on poly(styrene-butyl acrylate), in combination with covalently layer by layer (LBL) self-assemble process and hypercrosslinked post-treatment. Abundant microporous structures and a small number of mesoporous structures are formed in hypercorsslinked nanofilm and corresponding surface area derived from Brunauer-Emmett-Teller method (BET) were determined to be 605.7 m/g. The capacity of CO capture was also measured, which reach up to 53.6 wt% (12.2 mmol/g) at 273 K/1 bar, which is comparable to highest record. We have found that all the as prepared nanofilm with different thickness exhibited apparently enhanced micro- and meso-porosity after hypercrosslinking. Moreover, with the increase of thickness of nanofilm, the adsorption capacity decreases gradually, as well as the CO adsorption capacity. An excellent recycling capacity for CO capture have also found for this porous polymer nanofilm via repetitive adsorption-desorption assay. Our work confirmed that thickness controllable porous polymer nanofilm with superior CO capture capacity can be fabricated by a very simple strategy which can meet the challenges of the current CO capture and storage technology.
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http://dx.doi.org/10.1016/j.jcis.2019.12.038DOI Listing
March 2020

Preparation of thermo/redox/pH-stimulative poly(N-isopropylacrylamide-co-N,N'-dimethylaminoethyl methacrylate) nanogels and their DOX release behaviors.

J Biomed Mater Res A 2019 06 31;107(6):1195-1203. Epub 2019 Jan 31.

Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Ministry of Education, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China.

Stimuli-sensitive drug delivery systems show beneficial features of both medical and pharmaceutical fields. In this article, polymeric nanogel P (N-isopropylacrylamide-N,N '-dimethylaminoethyl methacrylate [NIPAM-DMAEMA]) (PND) with pH/redox/thermo-responsivenesses was synthesized by the in situ polymerization of NIPAM and DMAEMA for the controlled release of doxorubicin hydrochloride (DOX) and N,N '-bis(acryloyl)cystamine (BAC) and N,N '-methylenebisacrylamide (MBA) act as the crosslinkers, respectively. The structure, size, and zeta potential of PND-BAC and PND-MBA were further characterized. Moreover, after loading DOX, the encapsulation efficiency and the in vitro release behavior of PND-BAC/DOX and PND-MBA/DOX nanogels were discussed in detail. Compared to PND-MBA NGs, PND-BAC nanogels have redox degradability due to the presence of the crosslinker BAC. After loading DOX, the PND-BAC/DOX nanogel showed a higher encapsulation efficiency (81.6 ± 1.2)% and thermo- and pH-responsiveness as well as redox-responsive in vitro release. These properties together with excellent environmentally sensitive properties make PND-BAC as an attractive candidate for application in drug nanocarriers for the targeted drug delivery of model payloads. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1195-1203, 2019.
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http://dx.doi.org/10.1002/jbm.a.36611DOI Listing
June 2019

Synergistic Enhancement of Thermal Conductivity and Dielectric Properties in Al₂O₃/BaTiO₃/PP Composites.

Materials (Basel) 2018 Aug 26;11(9). Epub 2018 Aug 26.

State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

Multifunctional polymer composites with both high dielectric constants and high thermal conductivity are urgently needed by high-temperature electronic devices and modern microelectromechanical systems. However, high heat-conduction capability or dielectric properties of polymer composites all depend on high-content loading of different functional thermal-conductive or high-dielectric ceramic fillers (every filler volume fraction ≥ 50%, i.e., ≥ 50%), and an overload of various fillers ( + > 50%) will decrease the processability and mechanical properties of the composite. Herein, series of alumina/barium titanate/polypropylene (Al₂O₃/BT/PP) composites with high dielectric- and high thermal-conductivity properties are prepared with no more than 50% volume fraction of total ceramic fillers loading, i.e., ≤ 50%. Results showed the thermal conductivity of the Al₂O₃/BT/PP composite is up to 0.90 W/m·K with only 10% thermal-conductive Al₂O₃ filler, which is 4.5 times higher than the corresponding Al₂O₃/PP composites. Moreover, higher dielectric strength () is also found at the same loading, which is 1.6 times higher than PP, and the Al₂O₃/BT/PP composite also exhibited high dielectric constant ( ε r = 18 at 1000 Hz) and low dielectric loss (tan δ ≤ 0.030). These excellent performances originate from the synergistic mechanism between BaTiO₃ macroparticles and Al₂O₃ nanoparticles.
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http://dx.doi.org/10.3390/ma11091536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163919PMC
August 2018

Stepwise-acid-active organic/inorganic hybrid drug delivery system for cancer therapy.

Colloids Surf B Biointerfaces 2018 Jul 21;167:407-414. Epub 2018 Apr 21.

Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Key Laboratory for the Green Preparation and Application of Functional Materials of Ministry of Education, Hubei University, Wuhan, Hubei 430062, PR China. Electronic address:

Due to the difference of pH values between normal tissues, tumor tissues and intracellular environments, DOX@MSN-CD-PEG, a stepwise-acid-active organic/inorganic hybrid drug delivery system (DDS) was reported in this article. The inorganic mesoporous silica nanoparticle (MSN) was introduced for loading of doxorubicin hydrochloride (DOX). Then organic components were applied to achieve the stepwise-acid-active intracellular drug release: MSN was capped with a β-cyclodextrine (β-CD) based host-guest system via pH-sensitive epoxy bond. Then PEG was grafted outside of the carriers through pH-sensitive benzoic imine bond. With the protection of PEG layer, the carriers were difficult cellular uptake by normal cells but could be "acid-activated" for cytophagy by cancer cells in the slightly acidic environments in tumor tissues because of the abscission of PEG. Inside the cells, the more acidic environments could further "activate" the carriers to release DOX as the leaving of the host-guest system. The fabrication processes of DOX@MSN-CD-PEG were monitored. And the stepwise-acid-active property of which was investigated by acid-triggered PEG abscission studies and in vitro drug release studies at pH 7.4 and 6.5, respectively. The in vitro cellular cytotoxicity and cellular uptake behavior were also investigated. In summary, the stepwise-acid-active hybrid DDS should be considerable for cancer therapy.
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http://dx.doi.org/10.1016/j.colsurfb.2018.04.038DOI Listing
July 2018

Synthesis of PbS and Ag2S Nanorods via Polyol Process.

J Nanosci Nanotechnol 2018 Aug;18(8):5831-5836

Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials and Ministry of Education Key Laboratory for Synthesis and Applications of Organic Functional Molecules, Hubei University, Wuhan 430062, China.

PbS and Ag2S nanorods have been synthesized using a polyol process in the presence of poly(vinylpyrrolidone) (PVP). First, the production of Pb or Ag was realized via the thermal decomposition of a lead/silver salt. Then the Pb or Ag precursor was directly combined with S power under heating, leading to the formation of the final products. The samples were characterized by X-ray powder diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and energy dispersive X-ray spectroscopy (EDS). PbS cubes and cubes with a hole in the center were prepared under different reaction conditions. Possible formation mechanisms of different PbS or Ag2S morphologies have briefly been discussed.
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http://dx.doi.org/10.1166/jnn.2018.15443DOI Listing
August 2018

Low-Temperature and Solution-Processable Zinc Oxide Transistors for Transparent Electronics.

ACS Omega 2017 Dec 15;2(12):8990-8996. Epub 2017 Dec 15.

Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Key Laboratory for the Green Preparation and Application of Functional Materials, Ministry of Education, Hubei Key Laboratory of Polymer Materials, School of Materials Science and Engineering, Hubei University, Wuhan 430062, China.

Zinc oxide (ZnO) thin-film transistors (TFTs) have many promising applications in the areas of logic circuits, displays, ultraviolet detectors, and biosensors due to their high performances, facile fabrication processing, and low cost. The solution method is an important technique for low-cost and large fabrication of oxide semiconductor TFTs. However, a key challenge of solution-processable ZnO TFTs is the relatively high processing temperature (≥500 °C) for achieving high carrier mobility. Here, facile, low-cost, and solution-processable ZnO TFTs were fabricated under the annealing temperature of ≤300 °C. Dense and polycrystalline ZnO films were deposited by the spin-coating method. The ZnO TFTs showed the maximum electron mobility of 11 cm/V s and a high on/off ratio of >10 when the ZnO thin films were annealed at 300 °C. The mobility was extremely high among solution-processable undoped ZnO TFTs reported previously, even better than some high-cost indium-doped ZnO TFTs fabricated at low temperature. Furthermore, it is found that the mechanism of oxygen vacancies dominates the electron transport in ZnO thin film and interface behaviors of ZnO thin film and SiO gate insulator, and then dominates the performances of devices.
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http://dx.doi.org/10.1021/acsomega.7b01420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6645662PMC
December 2017

Study on β-cyclodextrin-complexed nanogels with improved thermal response for anticancer drug delivery.

Mater Sci Eng C Mater Biol Appl 2017 Sep 19;78:773-779. Epub 2017 Apr 19.

Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Ministry of Education, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, People's Republic of China. Electronic address:

For achievement of controllability in drug delivery, development of nanocarriers with thermal response is one of the most investigated stimulative strategies for oncological treatment. How to improve the thermosensitivity of the nanocarriers is an important factor for their successful drug delivery applications. In this study, a kind of complexed nanogels (PNACD) was developed by incorporating β-cyclodextrin (β-CD) into the nanogels of copolymers of N-isopropylacrylamide (NIPAM) and acrylic acid (AA) during their polymerization via in situ crosslinking of N,N'-methylenebisacrylamide (MBA) as a crosslinker. The complexed PNACD nanogels displayed a significantly enhanced thermosensitivity near body temperature compared to the β-CD-free nanogels (PNA), which is probably associated with the rapid volumetric transformation during heating/cooling process due to the formation of complexed (decomplexed) structure between β-CD and PNIPAM element. The PNACD nanogels can be used for loading of an anticancer drug (doxorubicin, DOX) with an encapsulation efficiency of 54±5%. The DOX-loaded nanogels displayed pH-/thermo-dual responsivenesses in drug release, which can be effectively internalized into KB cells (a human epithelial carcinoma cell line) to exert good anticancer bioactivity. This approach may enlighten design of novel nanocarriers for delivery of drugs beyond anticancer chemotherapeutic reagents.
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http://dx.doi.org/10.1016/j.msec.2017.04.096DOI Listing
September 2017

Stimulative nanogels with enhanced thermosensitivity for therapeutic delivery via β-cyclodextrin-induced formation of inclusion complexes.

Carbohydr Polym 2017 Jun 1;166:219-227. Epub 2017 Mar 1.

Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Ministry of Education, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China. Electronic address:

To explore the potential biomedical application of thermoresponsive nanosystems, it is important to enhance their thermosensitivity to improve the controllability in delivery of therapeutic agents. The present work develops multifunctional nanogels with enhanced thermosensitivity through copolymerization of N-isopropylacrylamide (NIPAM) and acrylic acid (AA) in the presence of β-cyclodextrin (β-CD), using N,N'-bis(acryloyl)cystamine (BAC) as a biodegradable crosslinker. The resulting nanogels display significantly improved sensitivity in deswelling (swelling) behavior upon temperature increase (decrease) around body temperature. The nanogels can effectively encapsulate doxorubicin (DOX), which can be released in an accelerated way under microenvironments that mimic intracellular reductive conditions and acidic tumor tissues. Release can also be remotely manipulated by increasing temperature. In vitro study indicates that the nanogels are quickly taken up by KB cells (a human epithelial carcinoma cell line), exerting improved anticancer cytotoxicity, showing their potential for delivery of therapeutic agents beyond anticancer drugs.
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http://dx.doi.org/10.1016/j.carbpol.2017.02.107DOI Listing
June 2017