Publications by authors named "Zheng Li"

3,329 Publications

  • Page 1 of 1

Genomic instability as a major mechanism for acquired resistance to EGFR tyrosine kinase inhibitors in cancer.

Authors:
Bing Liu Daniela Duenas Li Zheng Karen Reckamp Binghui Shen

Protein Cell 2021 Jul 28. Epub 2021 Jul 28.

Department of Cancer Genetics and Epigenetics, Beckman Research Institute of City of Hope, 1500 East Duarte Road, Duarte, CA, 91010, USA.

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http://dx.doi.org/10.1007/s13238-021-00855-6DOI Listing
July 2021

Increasing the electron selectivity of nanoscale zero-valent iron in environmental remediation: A review.

Authors:
Long Zhou Zheng Li Yunqiang Yi Eric Pokeung Tsang Zhanqiang Fang

J Hazard Mater 2021 Jul 21;421:126709. Epub 2021 Jul 21.

School of Environment, South China Normal University, University Town, Guangzhou 510006, China; Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Theoretical Chemistry of Environment, South China Normal University, Guangzhou 510006, China; Guangdong Technology Research Center for Ecological Management and Remediation of Water System, Guangzhou 510006, China. Electronic address:

Nanoscale zero-valent iron nanoparticles (nZVI) have been used for groundwater remediation and wastewater treatment due to their high reactivity, high adsorption capacity and nontoxicity. However, side reactions generally occur in tandem with the target contaminants removal process, resulting in poor electron selectivity (ES) of nZVI, and subsequently restricting its commercial application. Major efforts to increase ES of nZVI have been made in recent years. This review's objective is to provide a progress report on the significant developments in nZVI's ES during the past decade. Firstly, the definition of ES and its quantification approaches were documented, and the intrinsic (i.e. particle size, crystallinity, and surface area) and extrinsic factors (i.e. solutions pH, target contaminant concentration, and presence of co-contaminants) affecting the ES of nZVI were reported. The latest techniques for increasing ES were summarized in detail, with reference made to sulfidation, magnetization, carbon loading and other features. Then the mechanisms of those strategies for ES enhancement were described. Finally, some constructive suggestions on future research directions concerning nZVI's ES in the future were proposed.
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http://dx.doi.org/10.1016/j.jhazmat.2021.126709DOI Listing
July 2021

MagicChem: a MR system based on needs theory for chemical experiments.

Authors:
Zhigeng Pan Tianren Luo Mingmin Zhang Ning Cai Yongheng Li Jinda Miao Zheng Li Zhipeng Pan Yuze Shen Jijian Lu

Virtual Real 2021 Jul 22:1-16. Epub 2021 Jul 22.

Jing Hengyi Education College, Hangzhou Normal University, Hangzhou, China.

Real chemical experiments may be dangerous or pollute the environment; meanwhile, the preparation of drugs and reagents is time-consuming. Due to the above-mentioned reasons, few experiments can be actually operated by students, which is not conducive to the chemistry learning and the phenomena principle understanding. Recently, due to the impact of Covid-19, many schools adopt online teaching, which is even more detrimental to students' learning of chemistry. Fortunately, MR(mixed reality) technology provides us with the possibility of solving the safety issues and breaking the space-time constraints, while the theory of human needs (Maslow's hierarchical needs) provides us with a way to design a comfortable and stimulant MR system with realistic visual presentation and interaction. The paper combines with the theory of human needs to propose a new needs model for virtual experiment. Based on this needs model, we design and develop a comprehensive MR system called MagicChem, which offers a robust 6-DoF interactive and illumination consistent experimental space with virtual-real occlusion, supporting realistic visual interaction, tangible interaction, gesture interaction with touching, voice interaction, temperature interaction, olfactory interaction and virtual human interaction. User study shows that MagicChem satisfies the needs model better than other MR experimental environments that partially meet the needs model. In addition, we explore the application of the needs model in VR environment.

Supplementary Information: The online version contains supplementary material available at 10.1007/s10055-021-00560-z.
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http://dx.doi.org/10.1007/s10055-021-00560-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295458PMC
July 2021

RNA-binding protein ELAVL2 plays post-transcriptional roles in the regulation of spermatogonia proliferation and apoptosis.

Authors:
Chao Yang Chencheng Yao Zhiyong Ji Liangyu Zhao Huixing Chen Peng Li Ruhui Tian Erlei Zhi Yuhua Huang Xia Han Yan Hong Zhi Zhou Zheng Li

Cell Prolif 2021 Jul 23:e13098. Epub 2021 Jul 23.

Department of Andrology, The Center for Men's Health, Urologic Medical Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objectives: RNA-binding proteins (RBPs) play essential post-transcriptional roles in regulating spermatogonial stem cells (SSCs) maintenance and differentiation. We identified a conserved and SSCs-enriched RBP ELAVL2 from our single-cell sequencing data, but its function and mechanism in SSCs were unclear.

Materials And Methods: Expressions of ELAVL2 during human and mouse testis development were validated. Stable C18-4 and TCam-2 cell lines with overexpression and knockdown of ELAVL2 were established, which were applied to proliferation and apoptosis analysis. RNA immunoprecipitation and sequencing were used to identify ELAVL2 targets, and regulatory functions of ELAVL2 on target mRNAs were studied. Proteins interacting with ELAVL2 in human and mouse testes were identified using immunoprecipitation and mass spectrometric, which were validated by in vivo and in vitro experiments.

Results: ELAVL2 was testis-enriched and preferentially expressed in human and mouse SSCs. ELAVL2 was down-regulated in NOA patients. ELAVL2 promoted proliferation and inhibited apoptosis of C18-4 and TCam-2 cell lines via activating ERK and AKT pathways. ELAVL2 associated with mRNAs encoding essential regulators of SSCs proliferation and survival, and promoted their protein expression at post-transcriptional level. ELAVL2 interacted with DAZL in vivo and in vitro in both human and mouse testes.

Conclusions: Taken together, these results indicate that ELAVL2 is a conserved SSCs-enriched RBP that down-regulated in NOA, which regulates spermatogonia proliferation and apoptosis by promoting protein expression of targets.
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http://dx.doi.org/10.1111/cpr.13098DOI Listing
July 2021

Associations of TG/HDL Ratio with the Risk of Prediabetes and Diabetes in Chinese Adults: A Chinese Population Cohort Study Based on Open Data.

Authors:
Rongpeng Gong Yuanyuan Liu Gang Luo Wenjing Liu Ziqi Jin Zixin Xu Zheng Li Lixin Yang Xiaoxing Wei

Int J Endocrinol 2021 8;2021:9949579. Epub 2021 Jul 8.

Medical College of Qinghai University, Xining, Qinghai 810016, China.

Background: In the global chronic diseases, type 2 diabetes shows a significant upward trend, and there are more people before prediabetes (impaired glucose tolerance). Many patients with impaired glucose tolerance and undiagnosed diabetes do not know that their glucose metabolism system has been in a state of disorder. Every year, about 5% to 10% of prediabetics develop diabetes. One of the important achieving factors may be the increase in blood lipids. However, it is not clear whether the triglyceride/high-density lipoprotein ratio is associated with impaired glucose tolerance and diabetes in the Chinese population. Therefore, we investigated the relationship between triglyceride/high-density lipoprotein and impaired glucose tolerance and diabetes in the Chinese population.

Methods: We conducted a retrospective cohort study using data from the health screening program. The study included 116,855 participants from 32 locations in China, all of whom were adults over 20. Participants measured fasting blood glucose levels at each visit and collected information about their diabetes history. Impaired glucose tolerance was diagnosed as fasting blood glucose ≥6.00 mmol and self-reported diabetes mellitus. The patient was measured on the date of diagnosis or on his last visit (whichever comes first).

Results: The results showed that, after adjusting the potential confounding factors, the ratio of TG/HDL was positively correlated with the occurrence of prediabetes and diabetes, and there was a saturation effect. The inflection points were 1.04 and 1.33, respectively. The effect value and 95% confidence interval before and after the inflection point of impaired glucose tolerance patients were 1.57 and (1.42, 1.73) and 1.03 and (1.01, 1.05), respectively. The effect value and 95% confidence interval before and after the inflection point in patients with diabetes were 2.07 and (1.80, 2.39) and 1.08 and (1.04, 1.12).
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http://dx.doi.org/10.1155/2021/9949579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282372PMC
July 2021

Promising Therapeutic Targets for Treatment of Rheumatoid Arthritis.

Authors:
Jie Huang Xuekun Fu Xinxin Chen Zheng Li Yuhong Huang Chao Liang

Front Immunol 2021 9;12:686155. Epub 2021 Jul 9.

Department of Biology, Southern University of Science and Technology, Shenzhen, China.

Rheumatoid arthritis (RA) is a systemic poly-articular chronic autoimmune joint disease that mainly damages the hands and feet, which affects 0.5% to 1.0% of the population worldwide. With the sustained development of disease-modifying antirheumatic drugs (DMARDs), significant success has been achieved for preventing and relieving disease activity in RA patients. Unfortunately, some patients still show limited response to DMARDs, which puts forward new requirements for special targets and novel therapies. Understanding the pathogenetic roles of the various molecules in RA could facilitate discovery of potential therapeutic targets and approaches. In this review, both existing and emerging targets, including the proteins, small molecular metabolites, and epigenetic regulators related to RA, are discussed, with a focus on the mechanisms that result in inflammation and the development of new drugs for blocking the various modulators in RA.
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http://dx.doi.org/10.3389/fimmu.2021.686155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8299711PMC
July 2021

A TTP-incorporated scoring model for predicting mortality of solid tumor patients with bloodstream infection caused by Escherichia coli.

Authors:
Qing Zhang Hao-Yang Gao Ding Li Chang-Sen Bai Zheng Li Shan Zheng Wen-Fang Zhang Yun-Li Zhou Si-He Zhang

Support Care Cancer 2021 Jul 24. Epub 2021 Jul 24.

Department of Cell Biology, School of Medicine, Nankai University, 94 Weijin Road, Nankai District, Tianjin, 300071, People's Republic of China.

Background: Few mortality-scoring models are available for solid tumor patients who are predisposed to develop Escherichia coli-caused bloodstream infection (ECBSI). We aimed to develop a mortality-scoring model by using information from blood culture time to positivity (TTP) and other clinical variables.

Methods: A cohort of solid tumor patients who were admitted to hospital with ECBSI and received empirical antimicrobial therapy was enrolled. Survivors and non-survivors were compared to identify the risk factors of in-hospital mortality. Univariable and multivariable regression analyses were adopted to identify the mortality-associated predictors. Risk scores were assigned by weighting the regression coefficients with corresponding natural logarithm of the odds ratio for each predictor.

Results: Solid tumor patients with ECBSI were distributed in the development and validation groups, respectively. Six mortality-associated predictors were identified and included in the scoring model: acute respiratory distress (ARDS), TTP ≤ 8 h, inappropriate antibiotic therapy, blood transfusion, fever ≥ 39 °C, and metastasis. Prognostic scores were categorized into three groups that predicted mortality: low risk (< 10% mortality, 0-1 points), medium risk (10-20% mortality, 2 points), and high risk (> 20% mortality, ≥ 3 points). The TTP-incorporated scoring model showed excellent discrimination and calibration for both groups, with AUC being 0.833 vs 0.844, respectively, and no significant difference in the Hosmer-Lemeshow test (6.709, P = 0.48) and the chi-square test (6.993, P = 0.46). Youden index showed the best cutoff value of ≥ 3 with 76.11% sensitivity and 79.29% specificity. TTP-incorporated scoring model had higher AUC than no TTP-incorporated model (0.837 vs 0.817, P < 0.01).

Conclusions: Our TTP-incorporated scoring model was associated with improving capability in predicting ECBSI-related mortality. It can be a practical tool for clinicians to identify and manage bacteremic solid tumor patients with high risk of mortality.
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http://dx.doi.org/10.1007/s00520-021-06442-zDOI Listing
July 2021

[Analysis of the effect of sequential high-flow nasal canula oxygen therapy in post-extubation mechanically ventilated patients in intensive care unit].

Authors:
Peng Zhang Zheng Li Haijiao Jiang Quan Zhou Xiaoming Ye Liping Yuan Jiaofeng Wu Jingyi Wu Weihua Lu Xiubin Tao Xiaogan Jiang

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Jun;33(6):692-696

Department of Critical Care Medicine, Yijishan Hospital of Wannan Medical College, Anhui Provincial Clinical Research Center for Critical Respiratory Diseases, Wuhu 241000, Anhui, China. Corresponding author: Jiang Xiaogan, Email:

Objective: To observe the application effect of high-flow nasal canula oxygen therapy (HFNC) after extubation in patients with mechanical ventilation (MV) in the intensive care unit (ICU).

Methods: A prospective study was conducted. From January 2018 to June 2020, 163 MV patients admitted to Yijishan Hospital of Wannan Medical College were enrolled, and they were divided into HFNC group (82 cases) and traditional oxygen therapy group (81 cases) according to the oxygen therapy model. The patients included in the study were given conventional treatment according to their condition. In the HFNC group, oxygen was inhaled by a nasal high-flow humidification therapy instrument. The gas flow was gradually increased from 35 L/min to 60 L/min according to the patient's tolerance, and the temperature was set at 34-37 centigrade. The fraction of inspiration oxygen (FiO) was set according to the patient's pulse oxygen saturation (SpO) and SpO was maintained at 0.95-0.98. A disposable oxygen mask or nasal cannula was used to inhale oxygen in the traditional oxygen therapy group, and the oxygen flow was 5-8 L/min, maintaining the patient's SpO at 0.95-0.98. The differences in MV duration before extubation, total MV duration, intubation time, reintubation time, extubation failure rate, ICU mortality, ICU stay, and in-hospital stay were compared between the two groups, and weaning failure were analyzed.

Results: There was no significant differences in MV duration before extubation (days: 4.33±3.83 vs. 4.15±3.03), tracheal intubation duration (days: 4.34±1.87 vs. 4.20±3.35), ICU mortality [4.9% (4/82) vs. 3.7% (3/81)] and in-hospital stay [days: 28.93 (15.00, 32.00) vs. 27.69 (15.00, 38.00)] between HFNC group and traditional oxygen therapy group (all P > 0.05). The total MV duration in the HFNC group (days: 4.48±2.43 vs. 5.67±3.84) and ICU stay [days: 6.57 (4.00, 7.00) vs. 7.74 (5.00, 9.00)] were significantly shorter than those in the traditional oxygen therapy group, the reintubation duration of the HFNC group was significantly longer than that of the traditional oxygen therapy group (hours: 35.75±10.15 vs. 19.92±13.12), and the weaning failure rate was significantly lower than that of the traditional oxygen therapy group [4.9% (4/82) vs. 16.0% (13/81), all P < 0.05]. Among the reasons for weaning failure traditional oxygen therapy group had lower ability of airway secretion clearance than that of the HFNC group [8.64% (7/81) vs. 0% (0/82), P < 0.05], there was no statistically differences in the morbidity of heart failure, respiratory muscle weakness, hypoxemia, and change of consciousness between the two groups.

Conclusions: For MV patients in the ICU, the sequential application of HFNC after extubation can reduce the rate of weaning failure and the incidence of adverse events, shorten the length of ICU stay.
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http://dx.doi.org/10.3760/cma.j.cn121430-20210116-00074DOI Listing
June 2021

[Research progress on chemical constituents and quality control methods of Succus Bambusae].

Authors:
Hui-Min Feng Yun-Fei Hu Xi-Yao Zeng Ping Qiu Yuan-Xiang Li Zheng Li Wen-Long Li

Zhongguo Zhong Yao Za Zhi 2021 Jun;46(11):2753-2759

College of Traditional Chinese Medicine and Pharmaceutical Engineering,Tianjin University of Traditional Chinese Medicine Tianjin 301617,China State key Laboratory of Component-based Chinese Medicine,Tianjin University of Traditional Chinese Medicine Tianjin 301617,China.

Through the investigation of a large number of both domestic and overseas literatures and related quality standards, chemical compositions, quality evaluation system and quality control methods of Succus Bambusae were systematic summarized in this study. There were abundant chemical constituents in Succus Bambusae, mainly including volatile ingredients, amino acids, flavonoids, trace elements and vitamins, with high medicinal and edible value. The quality control methods involved traditional morphological identification, spectroscopy, chromatography and other techniques. However, the current quality standards of Succus Bambusae are relatively low, lacking safety indicators, and cannot effectively ensure its quality, seriously affecting the safety and effectiveness of its clinical use. Therefore, it is particularly important to establish a set of highly sensitive and specific quality evaluation system for Succus Bambusae. In this paper, the current research status of the chemical compositions and quality standards of Succus Bambusae were reviewed, with the purpose of providing a basis for further improvement of its quality evaluation system.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20210108.604DOI Listing
June 2021

Anisotropic Truncated Octahedral Au with Pt Deposition on Arris for Localized Surface Plasmon Resonance-Enhanced Photothermal and Photodynamic Therapy of Osteosarcoma.

Authors:
Yeyang Bu Ruqi Huang Zheng Li Peng Zhang Lijie Zhang Yun Yang Zhao Liu Kaijin Guo Fenglei Gao

ACS Appl Mater Interfaces 2021 Jul 22. Epub 2021 Jul 22.

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu 221002, People's Republic of China.

The multifunctional combined nanoplatform has a wide application prospect in the synergistic treatment of cancer. Nevertheless, the traditional treatment of phototherapy is limited by the catalytic nanomaterial itself, so the effect is not satisfactory. Here, the arris of the anisotropic truncated octahedral Au (TOh Au) was coated with noble metal Pt to form a spatial separation structure, which enhanced the local surface plasmonic resonance and thus boosted the photocatalytic effect. In this system, the highly efficient photocatalysis provides a strong guarantee for oncotherapy. On the one hand, the structure of arris deposition adequately improves the efficiency of photothermal conversion, which substantially improves the effectiveness of photothermal therapy. On the other hand, oxygen production of Pt ameliorates tumor hypoxia, and through the O self-production and sales mode, the growth and development of tumor were inhibited. Meanwhile, under the enhanced photocatalysis, more O were produced, which greatly evolved the treatment effect of photodynamic therapy. In the end, the addition of hyaluronic acid can specifically target osteosarcoma cells while improving the retention time and biocompatibility of the material in the body. Thus, the nanocomposite shows superexcellent synergistic enhancement of photothermal conversion efficiency and photodynamic capability and , which provides a potential possibility for osteosarcoma cure.
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http://dx.doi.org/10.1021/acsami.1c07181DOI Listing
July 2021

A Novel Neural Approach to Infinity-Norm Joint-Velocity Minimization of Kinematically Redundant Robots Under Joint Limits.

Authors:
Weibing Li Philip Wai Yan Chiu Zheng Li

IEEE Trans Neural Netw Learn Syst 2021 Jul 21;PP. Epub 2021 Jul 21.

Generally, the infinity-norm joint-velocity minimization (INVM) of physically constrained kinematically redundant robots can be formulated as time-variant linear programming (TVLP) with equality and inequality constraints. Zeroing neural network (ZNN) is an effective neural method for solving equality-constrained TVLP. For inequality-constrained TVLP, however, existing ZNNs become incompetent due to the lack of relevant derivative information and the inability to handle inequality constraints. Currently, there is no capable ZNN in the literature that has achieved the INVM of redundant robots under joint limits. To fill this gap, a classical INVM scheme is first introduced in this article. Then, a new joint-limit handling technique is proposed and employed to convert the INVM scheme into a unified TVLP with full derivative information. By using a perturbed Fisher-Burmeister function, the TVLP is further converted into a nonlinear equation. These conversion techniques lay a foundation for the success of designing a capable ZNN. To solve the nonlinear equation and the TVLP, a novel continuous-time ZNN (CTZNN) is designed and its corresponding discrete-time ZNN (DTZNN) is established using an extrapolated backward differentiation formula. Theoretical analysis is rigorously conducted to prove the convergence of the neural approach. Numerical studies are performed by comparing the DTZNN solver and the state-of-the-art (SOTA) linear programming (LP) solvers. Comparative results show that the DTZNN consumes the least computing time and can be a powerful alternative to the SOTA solvers. The DTZNN and the INVM scheme are finally applied to control two kinematically redundant robots. Both simulative and experimental results show that the robots successfully accomplish user-specified path-tracking tasks, verifying the effectiveness and practicability of the proposed neural approach and the INVM scheme equipped with the new joint-limit handling technique.
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http://dx.doi.org/10.1109/TNNLS.2021.3095122DOI Listing
July 2021

Selective recovery of phosphorus and urea from fresh human urine using a liquid membrane chamber integrated flow-electrode electrochemical system.

Authors:
Longqian Xu Ren Ding Yunfeng Mao Shuai Peng Zheng Li Yang Zong Deli Wu

Water Res 2021 Jul 12;202:117423. Epub 2021 Jul 12.

State Key Laboratory of Pollution Control and Resources Reuse, College of Environmental Science & Engineering, Tongji University, Shanghai 200092, PR China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, PR China. Electronic address:

Phosphorus (P) extraction from human urine is a potential strategy to address global resource shortage, but few approaches are able to obtain high-quality liquid P products. In this study, we introduced an innovative flow-electrode capacitive deionization (FCDI) system, also called ion-capture electrochemical system (ICES), for selectively extracting P and N (i.e., urea) from fresh human urine simply by integrating a liquid membrane chamber (LMC) using a pair of anion exchange membrane (AEM). In the charging process, negatively charged P ions (i.e., HPO and HPO) can be captured by acidic extraction solutions (e.g., solutions of HCl, HNO and HSO) on their way to the anode chamber, leading to the conversion of P ions to uncharged HPO, while other undesired ions such as Cl and SO are expelled. Simultaneously, uncharged urea molecules remain in the urine effluent with the removal of salt. Thus, high-purity phosphoric acid and urea solutions can be obtained in the LMC and spacer chambers, respectively. The purification of P in an acidic environment is ascribed largely to the competitive migration and protonation of ions. The latter contributes ~27% for the selective capture of P. Under the optimal operating conditions (i.e., ratio of the urine volume to the HCl volume = 7:3, initial pH of the extraction solution = 1.43, current density = 20 A/m and threshold pH ~ 2.0), satisfactory recovery performance (811 mg/L P with 73.85% purity and 8.3 g/L urea-N with 81.4% extraction efficiency) and desalination efficiency (91.1%) were obtained after 37.5 h of continuous operation. Our results reveal a promising strategy for improving in selective separation and continuous operation via adjustments to the cell configuration, initiating a new research dimension toward selective ion separation and high-quality P recovery.
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http://dx.doi.org/10.1016/j.watres.2021.117423DOI Listing
July 2021

Mental workload classification based on ignored auditory probes and spatial covariance.

Authors:
Shaohua Tang Chuancai Liu Qiankun Zhang Heng Gu Xiaoli Li Zheng Li

J Neural Eng 2021 Jul 19. Epub 2021 Jul 19.

Center for Cognition and Neuroergonomics, State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University - Zhuhai Campus, No.18, Jinfeng Road, Tangjiawan District, Zhuhai, Guangdong, 519087, CHINA.

Objective: Estimation of mental workload (MWL) levels by electroencephalography (EEG)-based mental state monitoring systems has been widely explored. Using event-related potentials (ERPs), elicited by ignored auditory probes, minimizes intrusiveness and has shown high performance for estimating MWL level when tested in laboratory situations. However, when facing real-world applications, the characteristics of ERP waveforms, like latency and amplitude, are often affected by noise, which leads to a decrease in classification performance. One approach to mitigating this is using spatial covariance, which is less sensitive to latency and amplitude distortion. In this study, we used ignored auditory probes in a single-stimulus paradigm and tested Riemannian processed covariance-based features for MWL level estimation in a realistic flight-control task.

Approach: We recorded EEG data with an 8-channel system from participants while they performed a simulated drone-control task and manipulated MWL levels (high and low) by task difficulty. We compared support vector machine classification performance based on frequency band power features versus features generated via the Riemannian log map operator from spatial covariance matrices. We also compared accuracy of using data segmented as auditory ERPs versus non-ERPs, for which data windows did not overlap with the ERPs.

Main Results: Classification accuracy of both types of features showed no significant difference between ERPs and non-ERPs. When we ignore auditory stimuli to perform continuous decoding, covariance-based features in the gamma band had area under the receiver-operating-characteristic curve (AUC) of 0.883, which was significantly higher than band power features (AUC 0.749).

Significance: This study demonstrates that Riemannian-processed covariance features are viable for MWL classification under a realistic experimental scenario.
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http://dx.doi.org/10.1088/1741-2552/ac15e5DOI Listing
July 2021

[Corrigendum] Integrated transcriptomic and epigenetic data analysis identifies aberrant expression of genes in acute myeloid leukemia with MLL‑AF9 translocation.

Authors:
Fangce Wang Zheng Li Guangming Wang Xiaoxue Tian Jie Zhou Wenlei Yu Zhuoyi Fan Lin Dong Jinyuan Lu Jun Xu Wenjun Zhang Aibin Liang

Mol Med Rep 2021 Sep 19;24(3). Epub 2021 Jul 19.

Department of Hematology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200092, P.R. China.

Following the publication of this paper, the authors have realized that the final article did not indicate in the Authors' Contribution section that Fangce Wang and Zheng Li made equal contributions to this work (FW and ZL performed most of the statistical analyses and drafted the initial version of the manuscript). Therefore, the affiliations for this paper should have been written as follows (changes are highlighted in bold): FANGCE WANG, ZHENG LI, GUANGMING WANG, XIAOXUE TIAN, JIE ZHOU, WENLEI YU, ZHUOYI FAN, LIN DONG, JINYUAN LU, JUN XU, WENJUN ZHANG and AIBIN LIANG Department of Hematology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200092; Medical Center for Stem Cell Engineering and Transformation, East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China. Contributed equally. The authors confirm that there are no further errors in the paper, and all the authors agree to this correction. The authors and the Editor apologize for any inconvenience caused. [the original article was published in 21: 883‑893, 2020, DOI: 10.3892/mmr.2019.10849].
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http://dx.doi.org/10.3892/mmr.2021.12295DOI Listing
September 2021

A representative dataset of the self-reproducing light ray family between the multiple distributed Bragg reflectors of multiple VCSELs and the inner surface of plane-convex mirror.

Authors:
Yude Li Zheng Li Mei Chen Jinglun Liu

Data Brief 2021 Aug 3;37:107257. Epub 2021 Jul 3.

Department of optoelectronic science and technology, Sichuan University, Chengdu 610064, China.

A system consisting of a plano-convex mirror and reflecting surfaces of Vertical Cavity Surface-Emitting Laser (VCSEL) Strip Array of Diode Lasers has been calculated and proved to have a self-reproducing ray sink in it. The initial positions and slopes of two representative groups of light rays are set, and the position and slope of each light ray at each Distributed Bragg Reflector (DBR) of Diode lasers are obtained by computation. The system is a folded resonator, every VCSEL is connected by the axis of the resonator, and this axis is formed by linking the correspondent reflective points on the inner spherical surface of the mirror and the reflective points on the Bragg mirrors. One approach could be to fabricate the array directly on a plane of a GaAs (or Si) plano-convex mirror. The resonator can contain many VCSELs, and therefore can afford a high quality laser beam and high-power output.
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http://dx.doi.org/10.1016/j.dib.2021.107257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267564PMC
August 2021

A numerical study of strong-post double-faced W-beam and Thrie-beam guardrails under impacts of vehicles of multiple size classes.

Authors:
Zheng Li Howie Fang Joshua Fatoki Matthew Gutowski Qian Wang

Accid Anal Prev 2021 Jul 13;159:106286. Epub 2021 Jul 13.

Department of Civil and Environmental Engineering, Manhattan College, Riverdale, NY 10471, USA.

Median barrier systems are safety features between opposite travel lanes to redirect or prevent errant vehicles from intruding into oncoming traffic lanes. Different barriers systems have been developed and used for decades. In this study, finite element (FE) modeling and simulations were adopted to study the performance of double-faced W-beam and Thrie-beam guardrails at 29- and 31-inch installation heights. The in-service guardrail performance was evaluated under impacts of multiple sized vehicles at Test Level 4 and Test Level 5 conditions specified in Manual for Assessing Safety Hardware (MASH). The effectiveness of the guardrails was assessed using guardrail dynamic deflections, vehicle responses, and vehicle redirection characteristics. The MASH exit box criterion, MASH evaluation criterion F (roll and pitch angle limit), and MASH evaluation criterion N (vehicle trajectory) were adopted in the evaluations. Additionally, occupant safety and injury risk were determined using occupant impact velocities (OIVs), occupant ridedown accelerations (ORAs), and acceleration severity indices (ASIs). The crash simulation results showed that both W-beam and Thrie-beam guardrails could retain all test vehicles and prevent them from getting into oncoming travel lanes. All the guardrails were considered generally effective in terms of occupant risk factors and vehicle impact responses. It was also observed that in certain cases, the installation height and the type of guardrail blockout could affect the impact severity for small-sized vehicles.
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http://dx.doi.org/10.1016/j.aap.2021.106286DOI Listing
July 2021

Trans-jugular intrahepatic portosystemic shunt in patients with hepatic cellular carcinoma: A preliminary study.

Authors:
Hong Dong Cunjing Zhang Zheng Li Haiyan Yang Yongzheng Wang Jibing Liu Bin Liu Shuzhi Mao

J Cancer Res Ther 2021 Jul;17(3):784-789

Interventional Oncology Institute, Shandong University; Department of Sterilization and Supply, The Second Hospital of Shandong University, Jinan, Shandong Province, China.

Purpose: To analyze the effects of trans-jugular intrahepatic portosystemic shunt (TIPS) on portal hypertension and liver function in patients with hepatocellular carcinoma (HCC).

Materials And Methods: Thirteen patients with hemorrhage caused by portal hypertension and HCC who received TIPS and antitumor treatment were retrospectively analyzed. Trans-arterial chemoembolization, microwave ablation, target therapy, and immunetherapy or combined therapy were performed to treat HCC. Child-Pugh score was applied to estimate liver functions before and after TIPS. Shunting patency, overall survival (OS), and progression-free survival were analyzed.

Results: The median age was 58 (interquartile range: 52.5-62.5) years. The ratio with ascites before and after TIPS was 84.6% (11/13) and 7.7% (1/13), with P < 0.001. The ratio with Child-Pugh A before and after TIPS were 61.5% (8/13) and 84.6% (11/13) respectively, with P = 0.179. Mean portal vein pressure before and after TIPS was 27.85 ± 7.02 mmHg and 16.23 ± 6.61 mmHg, respectively, with P = 0.001. Two-year shunting patency rate was 61.5%. Median OS was 29.8 ± 11.5 months (95% confidence interval [CI] 22.8-36.7), and median progression-free survival was 20.2 ± 13.2 months (95% CI 12.2-28.1).

Conclusion: TIPS could reduce ascites, down-regulate the Child-Pugh score, and give a chance for further anti-tumor therapy.
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http://dx.doi.org/10.4103/jcrt.jcrt_467_21DOI Listing
July 2021

Sub-Rayleigh second-order correlation imaging using spatially distributive colored noise speckle patterns.

Authors:
Zheng Li Xiaoyu Nie Fan Yang Xiangpei Liu Dongyu Liu Xiaolong Dong Xingchen Zhao Tao Peng M Suhail Zubairy Marlan O Scully

Opt Express 2021 Jun;29(13):19621-19630

We present a novel method, to our knowledge, to synthesize non-trivial speckle patterns that can enable sub-Rayleigh second-order correlation imaging. The speckle patterns acquire a unique anti-correlation in the spatial intensity fluctuation by introducing the blue noise distribution on spatial Fourier power spectrum to the input light fields through amplitude modulation. Illuminating objects with the blue noise speckle patterns can lead to a sub-diffraction limit imaging system with a resolution more than three times higher than first-order imaging, which is comparable to the resolving power of ninth order correlation imaging with thermal light. Our method opens a new route towards non-trivial speckle pattern generation by tailoring amplitudes in spatial Fourier power spectrum of the input light fields and provides a versatile scheme for constructing sub-Rayleigh imaging and microscopy systems without invoking complicated higher-order correlations.
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http://dx.doi.org/10.1364/OE.424284DOI Listing
June 2021

Vasal vessel-sparing microsurgical single-armed vasoepididymostomy to epididymal obstructive azoospermia: A retrospective control study.

Authors:
Peng Li Nachuan Liu Erlei Zhi Chencheng Yao Huixing Chen Ruhui Tian Yuhua Huang Liangyu Zhao Chao Yang Jingpeng Zhao Chenkun Shi Ming Liu Bo Wang Huirong Chen Zheng Li Shujie Xia

Andrologia 2021 Jul 14:e14133. Epub 2021 Jul 14.

Shanghai General Hospital of Nanjing Medical University, Shanghai, China.

This study aimed to evaluate the efficacy and safety of vasal vessel-sparing modified single-armed 2-suture longitudinal intussusception vasoepididymostomy (SA-LIVE) to epididymal obstructive azoospermia patients. Forty consecutive epididymal obstructive azoospermia cases, who underwent microsurgical vasoepididymostomy in Shanghai General Hospital from January 2019 to October 2019, were included in this study. Twenty cases underwent SA-LIVE (group A), and 20 cases underwent vasal vessel-sparing SA-LIVE (group B). Until March 2021, the mean follow-up period was 16.9 ± 4.1 (12-23) months. The overall patency rate was 82.5%, and 80% and 85% for group A and group B respectively. The mean time to achieve patency was 4.11 ± 2.74 months. The overall natural pregnancy rate was 51.5%(17/33) at the mean follow-up of 16.9 months. The natural pregnancy rate was 50.0% for group A and 52.9% for group B (p > .05). At the time of 6 months post-operation, the patency rate was 70% for group A and 80% for group B (p = .465); the natural pregnancy rate was 0% for group A and 31.3% for group B (p = .022). Vasal vessel-sparing SA-LIVE is safe and effective to achieve favourable patency and pregnancy rates. Preserving vasal vessel would improve natural pregnancy rate at a very early stage.
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http://dx.doi.org/10.1111/and.14133DOI Listing
July 2021

Autophagosomal Membrane Origin and Formation.

Authors:
Yi Yang Li Zheng Xiaoxiang Zheng Liang Ge

Adv Exp Med Biol 2021 ;1208:17-42

School of Life Sciences, Tsinghua University, Beijing, China.

Autophagosome formation is a regulated membrane remodeling process, which involves the generation of autophagosomal membrane precursors (vesicles), the assembly of the autophagosomal membrane precursors to form the phagophore, and phagophore elongation to complete the autophagosome. The sources of the autophagosomal membrane precursors are endomembrane compartments, such as the endoplasmic reticulum (ER), the ER-Golgi intermediate compartment (ERGIC), ER-exit sites (ERES), and endosomes. In response to stress, these structures are remodeled, to generate the early autophagosomal membrane precursors. The phagophore assembly site (PAS), which mainly localizes on the ER, harbors the site for autophagosomal membrane assembly, elongation, and completion. ATG proteins, membrane remodeling factors, and autophagic membranes follow a precise choreography to complete the overall process. In this chapter, we briefly discuss our current knowledge on the membrane origins of the autophagosome, as well as autophagosomal precursor generation, assembly, and expansion.
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http://dx.doi.org/10.1007/978-981-16-2830-6_2DOI Listing
July 2021

Quantitative Distinction between Noble Metals Located in Mesopores from those on the External Surface.

Authors:
Carolin Rieg Daniel Dittmann Zheng Li Robert Lawitzki Katrin Gugeler Sarah Maier Guido Schmitz Johannes Kästner Deven P Estes Michael Dyballa

Chemistry 2021 Jul 12. Epub 2021 Jul 12.

Universitat Stuttgart, Institute of Technical Chemistry, Pfaffenwaldring 55, 70569, Stuttgart, GERMANY.

We compare three methods for quantitatively distinguishing the location of noble metals (NM) in mesopores from those found on the external particle surface. MCM-41 and SBA-15 with NM either preferentially located in mesopores or on the external surface were prepared and characterized by TEM. We quantified arylphosphines forming complexes with NM by 31 P MAS NMR spectroscopy. Phosphine/NM ratios drop from 2.0 to 0.2 when increasing the probe diameter from 1.08 to 1.54 nm. The reaction between NM and triphenylphosphine (TPP) within 3.0 nm MCM-41 pores takes due to confinement effects multiple weeks. In contrast, external NM react with TPP instantly. A promising method is filling the pores using the pore volume impregnation technique with tetraethylorthosilicate (TEOS). TPP loading revealed that 66% of NM are located on the external surface of MCM-41. The pore filling method can be used in association with any probe molecule, also for the quantification of acid sites.
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http://dx.doi.org/10.1002/chem.202102076DOI Listing
July 2021

Age-dependent cross frequency coupling features from children to adults during general anesthesia.

Authors:
Zhenhu Liang Na Ren Xin Wen Haiwen Li Hang Guo Yaqun Ma Zheng Li Xiaoli Li

Neuroimage 2021 Jul 7;240:118372. Epub 2021 Jul 7.

State Key Laboratory of Cognitive Neuroscience and Learning, Beijing, 100875, China; Center for Cognition and Neuroergonomics, State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University at Zhuhai, Zhuhai, 519087, China. Electronic address:

Background: The frequency coupling characteristics in electroencephalogram (EEG) induced by anesthetics have been well studied in adults, but the investigation of the age-dependent cross frequency coupling features from children to adults is still lacking.

Methods: We analyzed EEG signals recorded from pediatric to adult patients (n = 131), separated into six age groups: <1 year (n = 15), 1-3 years (n = 23), 3-6 years (n = 19), 6-12 years (n = 18), 12-18 years (n = 16), and 18-45 years (n = 40). Age related EEG power and cross frequency coupling analysis (phase amplitude coupling (PAC) and quadratic phase coupling) of data from maintenance of a surgical state of anesthesia (MOSSA) was conducted. Also, for patients of ages less than 6 years, we analyzed the performance of cross frequency coupling derived indices in distinguishing the states of wakefulness, MOSSA, and recovery of consciousness (ROC).

Results: (1) During MOSSA, EEG power substantially increased with age from infancy to 3-6 years then decreased with age in the theta-gamma frequency bands. The infant group (<1 year) had the highest slow oscillation (SO) power among all age groups. (2) The distinct PAC pattern is absent in patients less than 1 year of age both in SO-alpha and delta-alpha frequency band coupling during propofol induced unconsciousness. The modulation index between delta and alpha oscillations in MOSSA increased with age. (3) Wavelet bicoherence derived indices reach their peaks in the 3-6 years group and then decrease with age growth. (4) The Diag_En index (normalized entropy of the diagonal bicoherence entries of the bicoherence matrix) performed the best at distinguishing different states for ages less than 6 years (p<0.05).

Conclusions: The combination of propofol induction and sevoflurane maintenance exhibited age-dependent EEG power spectra, PAC, and bicoherence, likely related to brain development. These observations suggest new rules for infant and child brain state monitoring during general anesthesia are needed.
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http://dx.doi.org/10.1016/j.neuroimage.2021.118372DOI Listing
July 2021

Fabricating polyoxometalates-stabilized single-atom site catalysts in confined space with enhanced activity for alkynes diboration.

Authors:
Yiwei Liu Xi Wu Zhi Li Jian Zhang Shu-Xia Liu Shoujie Liu Lin Gu Li Rong Zheng Jia Li Dingsheng Wang Yadong Li

Nat Commun 2021 Jul 9;12(1):4205. Epub 2021 Jul 9.

Department of Chemistry, Tsinghua University, Beijing, China.

Effecting the synergistic function of single metal atom sites and their supports is of great importance to achieve high-performance catalysts. Herein, we successfully fabricate polyoxometalates (POMs)-stabilized atomically dispersed platinum sites by employing three-dimensional metal-organic frameworks (MOFs) as the finite spatial skeleton to govern the accessible quantity, spatial dispersion, and mobility of metal precursors around each POM unit. The isolated single platinum atoms (Pt) are steadily anchored in the square-planar sites on the surface of monodispersed Keggin-type phosphomolybdic acid (PMo) in the cavities of various MOFs, including MIL-101, HKUST-1, and ZIF-67. In contrast, either the absence of POMs or MOFs yielded only platinum nanoparticles. [email protected] are seven times more active than the corresponding nanoparticles in the diboration of phenylacetylene, which can be attributed to the synergistic effect of the preconcentration of organic reaction substrates by porous MOFs skeleton and the decreased desorption energy of products on isolated Pt atom sites.
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http://dx.doi.org/10.1038/s41467-021-24513-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271022PMC
July 2021

Ultrafast imaging of spontaneous symmetry breaking in a photoionized molecular system.

Authors:
Min Li Ming Zhang Oriol Vendrell Zhenning Guo Qianru Zhu Xiang Gao Lushuai Cao Keyu Guo Qin-Qin Su Wei Cao Siqiang Luo Jiaqing Yan Yueming Zhou Yunquan Liu Zheng Li Peixiang Lu

Nat Commun 2021 Jul 9;12(1):4233. Epub 2021 Jul 9.

Wuhan National Laboratory for Optoelectronics and School of Physics, Huazhong University of Science and Technology, Wuhan, China.

The Jahn-Teller effect is an essential mechanism of spontaneous symmetry breaking in molecular and solid state systems, and has far-reaching consequences in many fields. Up to now, to directly image the onset of Jahn-Teller symmetry breaking remains unreached. Here we employ ultrafast ion-coincidence Coulomb explosion imaging with sub-10 fs resolution and unambiguously image the ultrafast dynamics of Jahn-Teller deformations of [Formula: see text] cation in symmetry space. It is unraveled that the Jahn-Teller deformation from C to C geometries takes a characteristic time of 20 ± 7 fs for this system. Classical and quantum molecular dynamics simulations agree well with the measurement, and reveal dynamics for the build-up of the C structure involving complex revival process of multiple vibrational pathways of the [Formula: see text] cation.
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http://dx.doi.org/10.1038/s41467-021-24309-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270947PMC
July 2021

Endophytic TR21 Improves Banana Plant Resistance to f. sp. and Promotes Root Growth by Upregulating the Jasmonate and Brassinosteroid Biosynthesis Pathways.

Authors:
Yunhao Sun Bingzhi Huang Ping Cheng Chunji Li Yanhong Chen Yongjian Li Li Zheng Juejun Xing Zhangyong Dong Guohui Yu

Phytopathology 2021 Jul 7. Epub 2021 Jul 7.

Innovative Institute for Plant Health, Zhongkai University of Agriculture and Engineering. Guangzhou 510225, People's Republic of China., Guangzhou, China.

The banana ( spp.) industry experiences dramatic annual losses from Fusarium wilt of banana (FWB) disease, which is caused by the fungus f. sp. (FOC). Pisang Awak banana Fenza No. 1 ( spp. cv. Fenza No. 1), a major banana cultivar with high resistance to FOC race 4, is considered to be ideal for growth in problematic areas. However, Fenza No. 1 is still affected by FOC race 1 in the field. TR21 is an endophytic strain isolated from orchids ( sp.). Axillary spraying of banana plants with TR21 controls FWB, decreasing the growth period and increasing yields in the field. In this study, we established that TR21 increases root growth in different monocotyledonous plant species. By axillary inoculation, TR21 induced a similar transcriptomic change as that induced by FOC race 1 but also upregulated the biosynthetic pathways for the phytohormones brassinosteroid and jasmonate in Fenza No. 1 root tissues, indicating that TR21 increases FWB resistance, shortens growth period, and increases yield of banana by inducing specific transcriptional reprogramming and modulating phytohormone levels. These findings will contribute to the identification of candidate genes related to plant resistance against fungi in a non-model system and facilitate further study and exploitation of endophytic biocontrol agents.
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http://dx.doi.org/10.1094/PHYTO-04-21-0159-RDOI Listing
July 2021

Plasma biomarker profiles and the correlation with cognitive function across the clinical spectrum of Alzheimer's disease.

Authors:
Zhenxu Xiao Xue Wu Wanqing Wu Jingwei Yi Xiaoniu Liang Saineng Ding Li Zheng Jianfeng Luo Hongchen Gu Qianhua Zhao Hong Xu Ding Ding

Alzheimers Res Ther 2021 Jul 5;13(1):123. Epub 2021 Jul 5.

Institute of Neurology, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Rd, Shanghai, China.

Background: Plasma biomarkers showed a promising value in the disease diagnosis and management of Alzheimer's disease (AD). However, profiles of the biomarkers and the associations with cognition across a spectrum of cognitive stages have seldom been reported.

Methods: We recruited 320 individuals with cognitive impairment and 131 cognitively normal participants from a memory clinic and a community cohort. Participants were classified into 6 groups based on their Clinical Dementia Rating (CDR) scores and clinical diagnosis, including AD, amnestic mild cognitive impairment (aMCI), and normal cognition (NC). A battery of neuropsychological tests was used to assess the global and domain-specific cognition. Plasma Aβ, Aβ, Aβ/Aβ, total tau (t-tau), neurofilament protein light chain (NfL), and phosphorylated tau at threonine 181 (p-tau181) were quantified using the single-molecule array (Simoa) platform.

Results: All the plasma markers (Aβ, Aβ, Aβ/Aβ, t-tau, NfL, p-tau181) showed certain discrepancies among NC, aMCI, and AD groups. The p-tau181 level showed a continuous escalating trend as the CDR scores increased from 0 (NC group) to 3 (severe AD). Compared with other biomarkers, p-tau181 had correlations with broader cognitive domains, covering global cognition (r = -0.536, P < 0.0001), memory (r = -0.481, P < 0.0001), attention (r = -0.437, P < 0.0001), visuospatial function (r = -0.385, P < 0.0001), and language (r = -0.177, P = 0.0003). Among participants with CDR ≥ 1, higher p-tau181 was correlated with worse global cognition (r = -0.301, P < 0.001).

Conclusions: Plasma p-tau181 had correlations with broader cognitive domains, suggesting its potential as a promising clinical-relevant blood-based biomarker.
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http://dx.doi.org/10.1186/s13195-021-00864-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259165PMC
July 2021

Premenstrual dysphoric disorder is associated with the longer length from clitoris to urethra.

Authors:
Zheng Li Meng-Jiao Xu Ying Jin Bing-Gen Zhu

BMC Womens Health 2021 07 5;21(1):266. Epub 2021 Jul 5.

Pudong New Area Mental Health Center, Tongji University School of Medicine, Shanghai, 200124, China.

Background: Premenstrual dysphoric disorder (PMDD) is a common, recently recognized, psychiatric condition among reproductive women, reflecting abnormal responsivity to ovarian steroids. Moreover, the potential organizational effect of prenatal sex hormones during PMDD has got attentions, but there have been considerably less of researches on this topic. The aim of this research was to investigate the possible role of prenatal androgen in the PMDD.

Methods: Anogenital distance (AGD), the distance between a woman's clitoris and her urethral meatus (CUMD), left and right 2D:4D ratios were measured in 77 subjects (25 patients with PMDD), as these anthropometric indicators are considered to indirectly reflect prenatal androgen exposures in utero.

Results: Patients with PMDD had a longer CUMD than controls (25.03 ± 4.73 vs. 22.07 ± 4.30, P = 0.008), while there were no significant difference between PMDD group and control group in the AGD and right and left 2D:4D ratios.

Conclusion: Atypical high prenatal androgen exposure might predispose individuals to be susceptible to PMDD.
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http://dx.doi.org/10.1186/s12905-021-01403-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259395PMC
July 2021

Nitrogen and phosphorus trajectories (1998-2030) under regional development strategy of mainland China.

Authors:
Li Zheng Xuekai Jing Qingwen Zhang Xiaoying Zhan Aiping Zhang Hafiz Athar Hussain

Sci Total Environ 2021 Jun 26;794:148655. Epub 2021 Jun 26.

Agricultural Clean Watershed Group, Institute of Environment and Sustainable Development in Agriculture, CAAS, Beijing 100081, China.

A good understanding of the nutrient cycle under a regional development strategy is crucial for nutrient management decision-making. Quantitatively assessment of nutrient flow under the regional coordinated development strategy in mainland China can provide scientific reference for achieving global high-quality coordinated economic and agricultural development. In this study, the characteristics of nitrogen (N) and phosphorus (P) flows of agricultural systems in mainland China from 1998 to 2030 were quantified using nutrient flows in food chain environment and resource (NUFER) model. The results revealed that national N and P surplus intensity were 50.3 and 18.6 kg·hm in 2018, respectively, and there is still space for soil nutrient retention. The national input and output of N and P showed a continuous upward trend over the last two decades. Chemical fertilizer application and livestock rearing are the key points for nutrient management in China's agricultural systems. Under the regional development strategy, considerable geographical variation in N and P surplus intensity was observed across the country. From 1998 to 2013, the regional distribution of N and P surplus intensity was in accordance with regional economic characteristics. Areas with higher N and P surplus intensities were mainly in the eastern and central regions. From 2014 to 2018, equal emphasis on ecology and economy in the Yangtze River Economic Belt allowed development without aggravating the deterioration of the N and P surplus in the region. Over the next 10 years, our simulation predicts that future nutrient footprints tend to decrease, and coordinated governance of regional development and agricultural environment protection are the key to regional sustainable development.
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http://dx.doi.org/10.1016/j.scitotenv.2021.148655DOI Listing
June 2021

Structural basis for the dimerization mechanism of human transcription factor E3.

Authors:
Guang Yang Peifeng Li Zaizhou Liu Siqi Wu Chen Zhuang Hang Qiao Li Zheng Pengfei Fang Chuanhu Lei Jing Wang

Biochem Biophys Res Commun 2021 Jul 2;569:41-46. Epub 2021 Jul 2.

State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China; School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, 1 Sub-lane Xiangshan, Hangzhou, 310024, China. Electronic address:

The transcription factor for immunoglobulin heavy-chain enhancer 3 (TFE3) is a member of the microphthalmia (MiT/TFE) transcription factor family. Dysregulation of TFE3 due to chromosomal abnormalities is associated with a subset of human renal cell carcinoma. Little structural information of this key transcription factor has been reported. In this study, we determined the crystal structure of the helix-loop-helix leucine zipper (HLH-Lz) domain of human TFE3 to a resolution of 2.6 Å. The HLH-Lz domain is critical for the dimerization and function of TFE3. Our structure showed that the conserved HLH region formed a four-helix bundle structure with a predominantly hydrophobic core, and the leucine zipper region contributed to the function of TFE3 by promoting dimer interaction and providing partner selectivity. Together, our results elucidated the dimerization mechanism of this important transcription factor, providing the structural basis for the development of inhibiting strategies for treating TFE3 dysregulated diseases.
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http://dx.doi.org/10.1016/j.bbrc.2021.06.091DOI Listing
July 2021

A pH-responsive mesoporous silica nanoparticles-based drug delivery system with controlled release of andrographolide for OA treatment.

Authors:
Mingwei He Zainen Qin Xiaonan Liang Xixi He Bikang Zhu Zhenhui Lu Qingjun Wei Li Zheng

Regen Biomater 2021 Aug 30;8(4):rbab020. Epub 2021 Jun 30.

Guangxi Engineering Center in Biomedical Material for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, No. 22 Shuangyong Road, Qingxiu District, Nanning 530021, China.

Andrographolide (AG) has favorable anti-inflammatory and antioxidative capacity. However, it has low bioavailability due to high lipophilicity and can be easily cleared by the synovial fluid after intra-articular injection, leading to low therapeutic efficiency in osteoarthritis (OA). Herein, we designed a nano-sized pH-responsive drug delivery system (DDS) for OA treatment by using modified mesoporous silica nanoparticles (MSNs) with pH-responsive polyacrylic acid (PAA) for loading of AG to form [email protected] nanoplatform. The nanoparticles have uniform size (∼120 nm), high drug loading efficiency (22.38 ± 0.71%) and pH-responsive properties, beneficial to sustained release in OA environment. Compared with AG, [email protected] showed enhanced antiarthritic efficacy and chondro-protective capacity based on IL-1β-stimulated chondrocytes and anterior cruciate ligament transection-induced rat OA model, as demonstrated by lower expression of inflammatory factors and better prevention of proteoglycan loss. Therefore, the [email protected] nanoplatform may be developed as a promising OA-specific and on-demand DDS.
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http://dx.doi.org/10.1093/rb/rbab020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242227PMC
August 2021
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