Publications by authors named "Zheng Huang"

502 Publications

Deciphering the Dynamic Proteomics of Mesenchymal Stem Cells in Critical Limb Ischemia.

Front Cell Dev Biol 2021 30;9:682476. Epub 2021 Jun 30.

Department of Cardiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.

Objective: Regenerative therapy using mesenchymal stem cells (MSC) is a promising therapeutic method for critical limb ischemia (CLI). To understand how the cells are involved in the regenerative process of limb ischemia locally, we proposed a metabolic protein labeling method to label cell proteomes and then decipher the proteome dynamics of MSCs in ischemic hind limb.

Methods And Results: In this study, we overexpressed mutant methionyl-tRNA synthetase (MetRS), which could utilize azidonorleucine (ANL) instead of methionine (Met) during protein synthesis in MSCs. Fluorescent non-canonical amino-acid tagging (FUNCAT) was performed to detect the utilization of ANL in mutant MSCs. Mice with hindlimb ischemia (HLI) or Sham surgery were treated with MetRS MSCs or PBS, followed by i.p. administration of ANL at days 0, 2 6, and 13 after surgery. FUNCAT was also performed in hindlimb tissue sections to demonstrate the incorporation of ANL in transplanted cells . At days 1, 3, 7, and 14 after the surgery, laser doppler imaging were performed to detect the blood reperfusion of ischemic limbs. Ischemic tissues were also collected at these four time points for histological analysis including HE staining and vessel staining, and processed for click reaction based protein enrichment followed by mass spectrometry and bioinformatics analysis. The MetRS MSCs showed strong green signal in cell culture and in HLI muscles as well, indicating efficient incorporation of ANL in nascent protein synthesis. By 14 days post-treatment, MSCs significantly increased blood reperfusion and vessel density, while reducing inflammation in HLI model compared to PBS. Proteins enriched by click reaction were distinctive in the HLI group vs. the Sham group. 34, 31, 49, and 26 proteins were significantly up-regulated whereas 28, 32, 62, and 27 proteins were significantly down-regulated in HLI vs. Sham at days 1, 3, 7, and 14, respectively. The differentially expressed proteins were more pronounced in the pathways of apoptosis and energy metabolism.

Conclusion: In conclusion, mutant MetRS allows efficient and specific identification of dynamic cell proteomics , which reflect the functions and adaptive changes of MSCs that may be leveraged to understand and improve stem cell therapy in critical limb ischemia.
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http://dx.doi.org/10.3389/fcell.2021.682476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278824PMC
June 2021

The TP53-Related Signature Predicts Immune Cell Infiltration, Therapeutic Response, and Prognosis in Patients With Esophageal Carcinoma.

Front Genet 2021 16;12:607238. Epub 2021 Jun 16.

Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Department of Pathology, Shihezi University School of Medicine, Shihezi, China.

TP53 mutation (TP53) is one of the most common gene mutations and frequently occurs in many cancers, especially esophageal carcinoma (ESCA), and it correlates with clinical prognostic outcomes. Nevertheless, the mechanisms by which TP53 regulates the correlation between ESCA and prognosis have not been sufficiently studied. Here, in the current research, we constructed a TP53-related signature to predict the prognosis of patients with esophageal cancer and successfully verified this model in patients in the TP53 mutant group, esophageal squamous cell carcinoma group, and adenocarcinoma group. The risk scores proved to be better independent prognostic factors than clinical features, and prognostic features were combined with other clinical features to establish a convincing nomogram to predict overall survival from 1 to 3 years. In addition, we further predicted the tumor immune cell infiltration, chemical drugs, and immunotherapy responses between the high-risk group and low risk group. Finally, the gene expression of the seven-gene signature (AP002478.1, BHLHA15, FFAR2, IGFBP1, KCTD8, PHYHD1, and SLC26A9) can provide personalized prognosis prediction and insights into new treatments.
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http://dx.doi.org/10.3389/fgene.2021.607238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256894PMC
June 2021

Radiological and clinical outcomes of balloon kyphoplasty for osteoporotic vertebral compression fracture in patients with rheumatoid arthritis.

J Orthop Surg Res 2021 Jul 6;16(1):435. Epub 2021 Jul 6.

Department of Spine Surgery, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, No.540 Xinhua Road, Shanghai, 200052, China.

Background: This study was conducted to investigate the outcomes and complications of balloon kyphoplasty (KP) for the treatment of osteoporotic vertebral compression fracture (OVCF) in patients with rheumatoid arthritis (RA) and compare its radiological and clinical effects with OVCF patients without RA.

Methods: Ninety-eight patients in the RA group with 158 fractured vertebrae and 114 patients in the control group with 150 vertebrae were involved in this study. Changes in compression rate, local kyphotic angle, visual analog scale (VAS) and Oswestry disability index (ODI) scores, conditions of bone cement leakage, refracture of the operated vertebrae, and new adjacent vertebral fractures were examined after KP. In addition, patients in the RA group were divided into different groups according to the value of erythrocyte sedimentation rate (ESR), c-reactive protein (CRP), and whether they were glucocorticoid users or not to evaluate their influence on the outcomes of KP.

Results: KP procedure significantly improved the compression rate, local kyphotic angle, and VAS and ODI scores in both RA and control groups (p<0.05). Changes in compression rate and local kyphotic angle in the RA group were significantly larger than that in the control group (p<0.05), and patients with RA suffered more new adjacent vertebral fractures after KP. The outcomes and complications of KP from different ESR or CRP groups did not show significant differences. The incidence of cement leakage in RA patients with glucocorticoid use was significantly higher than those who did not take glucocorticoids. In addition, RA patients with glucocorticoid use suffered more intradiscal leakage and new adjacent vertebral fractures.

Conclusions: OVCF patients with RA obtained more improvement in compression rate and local kyphotic angle after KP when compared to those without RA, but they suffered more new adjacent vertebral fractures. Intradiscal leakage and new adjacent vertebral fractures occurred more in RA patients with glucocorticoid use.

Trial Registration: Retrospectively registered.
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http://dx.doi.org/10.1186/s13018-021-02573-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259446PMC
July 2021

Mammal assemblage composition predicts global patterns in emerging infectious disease risk.

Glob Chang Biol 2021 Jul 2. Epub 2021 Jul 2.

Wildlife Ecology and Conservation Group, Wageningen University and Research, Wageningen, The Netherlands.

As a source of emerging infectious diseases, wildlife assemblages (and related spatial patterns) must be quantitatively assessed to help identify high-risk locations. Previous assessments have largely focussed on the distributions of individual species; however, transmission dynamics are expected to depend on assemblage composition. Moreover, disease-diversity relationships have mainly been studied in the context of species loss, but assemblage composition and disease risk (e.g. infection prevalence in wildlife assemblages) can change without extinction. Based on the predicted distributions and abundances of 4466 mammal species, we estimated global patterns of disease risk through the calculation of the community-level basic reproductive ratio R0, an index of invasion potential, persistence, and maximum prevalence of a pathogen in a wildlife assemblage. For density-dependent diseases, we found that, in addition to tropical areas which are commonly viewed as infectious disease hotspots, northern temperate latitudes included high-risk areas. We also forecasted the effects of climate change and habitat loss from 2015 to 2035. Over this period, many local assemblages showed no net loss of species richness, but the assemblage composition (i.e. the mix of species and their abundances) changed considerably. Simultaneously, most areas experienced a decreased risk of density-dependent diseases but an increased risk of frequency-dependent diseases. We further explored the factors driving these changes in disease risk. Our results suggest that biodiversity and changes therein jointly influence disease risk. Understanding these changes and their drivers and ultimately identifying emerging infectious disease hotspots can help health officials prioritize resource distribution.
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http://dx.doi.org/10.1111/gcb.15784DOI Listing
July 2021

Should singleton birth weight standards be applied to identify small-for-gestational age twins?: analysis of a retrospective cohort study.

BMC Pregnancy Childbirth 2021 Jun 25;21(1):446. Epub 2021 Jun 25.

Foshan Institute of Fetal Medicine, Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, 11 Renminxi Road, Guangdong, 528000, Foshan, China.

Background: Twin birth weight percentiles are less popular in clinical management among twin pregnancies compared with singleton ones in China. This study aimed to compare the incidence and neonatal outcomes of small for gestational age (SGA) twins between the use of singleton and twin birth weight percentiles.

Methods: This was a retrospective cohort study of 3,027 pregnancies with liveborn twin pairs at gestational age of > 28 weeks. The newborns were categorized as SGA when a birthweight was less than the 10th percentile based on the singleton and twin references derived from Chinese population. Logistic regression models with generalized estimated equation (GEE) were utilized to evaluate the association between SGA twins and neonatal outcomes including neonatal unit admission, neonatal jaundice, neonatal respiratory distress (NRDS), neonatal asphyxia, ventilator support, hypoxic ischemic encephalopathy (HIE), bronchopulmonary dysplasia (BPD), necrotizing enterocolitis (NEC), intracranial hemorrhage (ICH), culture-proven sepsis, neonatal death within 28 days after birth as well as the composite outcome.

Results: The incidence of SGA was 33.1 % based on the singleton reference and 7.3 % based on the twin reference. Both of SGA newborns defined by the singleton and twin references were associated with increases in neonatal unit admission, neonatal jaundice and ventilator support. In addition, SGA newborns defined by the twin reference were associated with increased rates of BPD (aOR, 2.61; 95 % CI: 1.18-5.78) as well as the severe composite outcome (aOR, 1.93; 95 % CI: 1.07-3.47).

Conclusions: The use of singleton birth weight percentiles may result in misdiagnosed SGA newborns in twin gestations and the twin birth weight percentiles would be more useful to identify those who are at risk of adverse outcomes.
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http://dx.doi.org/10.1186/s12884-021-03907-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234673PMC
June 2021

Protective effect of FSDJN7O5 and FHNFQ23M3 on diarrhea caused by enterotoxigenic .

Food Funct 2021 Jun 24. Epub 2021 Jun 24.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China. and School of Food Science and Technology, Jiangnan University, Wuxi, China and National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, China.

Enterotoxigenic Escherichia coli (ETEC) is the main bacterial cause of diarrhea among children in developing countries and of traveler's diarrhea. In this study, a mouse model was used to evaluate the effect of Bifidobacterium on alleviating diarrhea caused by ETEC. The results showed that B. breve FHNFQ23M3 and B. bifidum FSDJN7O5 could relieve the symptoms of diarrhea. Both strains significantly reduced the stool water content, restored the villi structure in the jejunum and ameliorated the fecal short-chain fatty acid (SCFA) content. In addition, B. breve FHNFQ23M3 restored body weight to the level before ETEC challenge and significantly reduced interferon-γ (IFN-γ), while B. bifidum FSDJN7O5 significantly improved interleukin (IL)-10. Furthermore, all the Bifidobacterium strains used in this study could significantly downregulate tumor necrosis factor-α (TNF-α) and restore the unbalanced gut microbiota, which had a high content of pathogenic Escherichia-Shigella and low content of Blautia and Clostridium innocuum groups due to ETEC. All the results proved that Bifidobacterium could be a potential probiotic for alleviating diarrhea from ETEC infection.
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http://dx.doi.org/10.1039/d1fo00504aDOI Listing
June 2021

Ferredoxin reductase regulates proliferation, differentiation, cell cycle and lipogenesis but not apoptosis in SZ95 sebocytes.

Exp Cell Res 2021 Jun 4;405(2):112680. Epub 2021 Jun 4.

Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China; Medical Cosmetic and Plastic Surgery Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. Electronic address:

Ferredoxin reductase (FDXR), a mitochondrial membrane-associated flavoprotein, is essential for electron transfer and modulates p53-dependent apoptosis in cancer cells.FDXR may be implicated in epidermal and sebocytic differentiation, but its explicit function in sebocytes remains to be elucidated. In the present study, immunohistochemistry revealed that FDXR expression was increased in sebaceous cells of acne lesions. FDXR, PPARγ, LXRα/β, SREBP1 and Sox9 expression was incremental during sebocyte differentiation. FDXR overexpression induced by Ad-GFP-FDXR infection enhanced differentiation, reactive oxygen species (ROS), lipogenesis and PPARγ expression, and consequnently inhibited proliferation in SZ95 sebocytes. Flow cytometry showed that FDXR overexpression induced significant blockade of G2/M phase but had no effect on sub-G1 (apoptotic) sebocytes. Insulin-like growth factor-1 (IGF-1)-induced FDXR and PPARγ expression and lipogenesis were abolished by pretreatment with PI3K inhibitor LY294002. These results suggest that FDXR overexpression might promote differentiation and lipogenesis via ROS production and suppress proliferation via G2/S blockade in SZ95 sebocytes. IGF-1 could facilitate differentiation and lipogenesis through PI3K/Akt/FDXR pathway. FDXR could serve as a potential marker of advanced sebaceous differentiation, and its overexpression may be involved in the development of acne lesions.
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http://dx.doi.org/10.1016/j.yexcr.2021.112680DOI Listing
June 2021

DUDA-Net: a double U-shaped dilated attention network for automatic infection area segmentation in COVID-19 lung CT images.

Int J Comput Assist Radiol Surg 2021 Jun 5. Epub 2021 Jun 5.

School of Automation and Electrical Engineering, Shenyang Ligong University, Shenyang, China.

Purpose: The global health crisis caused by coronavirus disease 2019 (COVID-19) is a common threat facing all humankind. In the process of diagnosing COVID-19 and treating patients, automatic COVID-19 lesion segmentation from computed tomography images helps doctors and patients intuitively understand lung infection. To effectively quantify lung infections, a convolutional neural network for automatic lung infection segmentation based on deep learning is proposed.

Method: This new type of COVID-19 lesion segmentation network is based on a U-Net backbone. First, a coarse segmentation network is constructed to extract the lung areas. Second, in the encoding and decoding process of the fine segmentation network, a new soft attention mechanism, namely the dilated convolutional attention (DCA) mechanism, is introduced to enable the network to focus on better quantitative information to strengthen the network's segmentation ability in the subtle areas of the lesions.

Results: The experimental results show that the average Dice similarity coefficient (DSC), sensitivity (SEN), specificity (SPE) and area under the curve of DUDA-Net are 87.06%, 90.85%, 99.59% and 0.965, respectively. In addition, the introduction of a cascade U-shaped network scheme and DCA mechanism can improve the DSC by 24.46% and 14.33%, respectively.

Conclusion: The proposed DUDA-Net approach can automatically segment COVID-19 lesions with excellent performance, which indicates that the proposed method is of great clinical significance. In addition, the introduction of a coarse segmentation network and DCA mechanism can improve the COVID-19 segmentation performance.
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http://dx.doi.org/10.1007/s11548-021-02418-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178668PMC
June 2021

Association between gestational weight gain and perinatal outcomes among twin gestations based on the 2009 Institute of Medicine (IOM) guidelines: a systematic review.

J Matern Fetal Neonatal Med 2021 May 27:1-15. Epub 2021 May 27.

Foshan Institute of Fetal Medicine, Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, Foshan, China.

Background: Gestational weight gain (GWG) has been understudied among twin pregnancies. This systematic review aimed to review the data on the associations between GWG, based on the 2009 Institute of Medicine (IOM) guidelines and pregnancy outcomes among twin gestations.

Methods: A systematic review was performed according to the PRISMA guidelines. A search for eligible studies published from January 2010 to August 2020 was conducted in the EMBASE, PubMed, Web of Science, ScienceDirect, and Cochrane databases. The methodological quality of the included studies was assessed using the Newcastle-Ottawa Scale. Data on study characteristics and main findings were extracted independently by two reviewers using a standard form. Outcomes of interest included (spontaneous) preterm birth (PTB), gestational hypertensive disorder (gestational hypertension and eclampsia), and small for gestational age (SGA).

Results: Eighteen observational studies of twin gestations met the inclusion criteria. GWG below the IOM recommendations was reported to be associated with increased PTB and SGA while GWG above the recommendation was associated with increased gestational hypertensive disorder. However, the results were inconsistent. Methodological limitations, such as a retrospective design, the use of weekly GWG, a small sample size and insufficient adjustment, impeded the clarification of the association between GWG and perinatal outcomes. In addition, the optimal GWG for underweight women was not fully studied.

Conclusions: The maintenance of weight gain within the 2009 IOM guidelines would decrease the risks of adverse outcomes among twin pregnancies. However, rigorous studies are warranted to provide robust evidence to refine the optimal GWG among twin gestations.
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http://dx.doi.org/10.1080/14767058.2021.1918083DOI Listing
May 2021

Recent Advances in Metal-Organic Frameworks Derived Nanocomposites for Photocatalytic Applications in Energy and Environment.

Adv Sci (Weinh) 2021 Jul 24;8(14):e2100625. Epub 2021 May 24.

College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, EX4 4QF, UK.

Solar energy is a key sustainable energy resource, and materials with optimal properties are essential for efficient solar energy-driven applications in photocatalysis. Metal-organic frameworks (MOFs) are excellent platforms to generate different nanocomposites comprising metals, oxides, chalcogenides, phosphides, or carbides embedded in porous carbon matrix. These MOF derived nanocomposites offer symbiosis of properties like high crystallinities, inherited morphologies, controllable dimensions, and tunable textural properties. Particularly, adjustable energy band positions achieved by in situ tailored self/external doping and controllable surface functionalities make these nanocomposites promising photocatalysts. Despite some progress in this field, fundamental questions remain to be addressed to further understand the relationship between the structures, properties, and photocatalytic performance of nanocomposites. In this review, different synthesis approaches including self-template and external-template methods to produce MOF derived nanocomposites with various dimensions (0D, 1D, 2D, or 3D), morphologies, chemical compositions, energy bandgaps, and surface functionalities are comprehensively summarized and analyzed. The state-of-the-art progress in the applications of MOF derived nanocomposites in photocatalytic water splitting for H generation, photodegradation of organic pollutants, and photocatalytic CO reduction are systemically reviewed. The relationships between the nanocomposite properties and their photocatalytic performance are highlighted, and the perspectives of MOF derived nanocomposites for photocatalytic applications are also discussed.
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http://dx.doi.org/10.1002/advs.202100625DOI Listing
July 2021

Circular RNA ITCH promotes extracellular matrix degradation via activating Wnt/β-catenin signaling in intervertebral disc degeneration.

Aging (Albany NY) 2021 05 18;13(10):14185-14197. Epub 2021 May 18.

Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Intervertebral disc degeneration (IDD) is the prevailing spine disorder and is associated with musculoskeletal disease. The extracellular matrix (ECM) degradation is an essential hallmark of IDD progression. Circular RNAs (circRNAs), as crucial cellular regulators, participate in multiple pathological processes including IDD. Here, we tried to explore the effect of circITCH on the ECM degradation of IDD and the underlying mechanism. Significantly, the expression levels of circITCH were elevated in the IDD patients' nucleus pulposus (NP) tissues relative to that of normal cases. CircITCH promoted apoptosis and decreased proliferation of NP cells. CircITCH contributed to ECM degradation, as demonstrated by increased ADAMTS4 and MMP13 expression and decreased aggrecan and collagen II expression. Mechanically, miR-17-5p could be sponged by circITCH and miR-17-5p inhibited ECM degradation by repressing SOX4 in degenerative NP cells. CircITCH could activate Wnt/β-catenin pathway by targeting miR-17-5p/SOX4 signaling. SOX4 overexpression, miR-17-5p inhibitor, or Wnt/β-catenin signaling activator LiCl was able to reverse circITCH knockdown-inhibited apoptosis and ECM degradation, and circITCH knockdown-enhanced proliferation in NP cells. Thus, we conclude that circITCH promotes ECM degradation in IDD by activating Wnt/β-catenin through miR-17-5p/SOX4 signaling. Our finding presents novel insight into the mechanism that circITCH modulates the IDD progression. CircITCH and SOX4 may serve as potential targets for IDD therapy.
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http://dx.doi.org/10.18632/aging.203036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202898PMC
May 2021

The association of hypertensive disorders of pregnancy with small for gestational age and intertwin birthweight discordance.

J Clin Hypertens (Greenwich) 2021 Jul 20;23(7):1354-1362. Epub 2021 May 20.

Foshan Institute of Fetal Medicine, Affiliated Foshan Maternity & Child Healthcare Hospital, Southern Medical University, Foshan, China.

Available evidence shows conflicting results regarding the association between hypertensive disorders of pregnancy (HDPs)/preeclampsia (PE) and small for gestational age (SGA) and birthweight discordance (BWD). This retrospective study of 2131 twin pregnancies aimed to evaluate the association of HDPs/PE with the presence of SGA and BWD. The eligible pregnancies were categorized into four study groups: concordant pairs without SGA fetuses, discordant pairs without SGA fetuses, concordant pairs with SGA fetuses, and discordant pairs with SGA fetuses. We applied binary logistic regression models to compare the incidence of HDPs/PE and multinomial logit regression models to evaluate the severity of PE between the study groups. The models were adjusted for potential confounders. Increases in HDPs were observed in concordant (aOR, 2.33; 95% CI: 1.46-3.73) and discordant (aOR, 3.50; 95% CI: 2.26-5.43) pregnancies with SGA fetuses but not in discordant pregnancies without SGA fetuses (aOR, 1.42; 95% CI: 0.81-2.49); increases in PE were also found in concordant (aOR, 1.87; 95% CI: 1.08-3.23) and discordant (aOR, 3.75; 95% CI: 2.36-5.96) pregnancies with SGA fetuses but not in discordant pregnancies without SGA fetuses (aOR, 1.34; 95% CI: 0.71-2.52). Discordant pregnancies with SGA fetuses were associated with severe PE (aRRR, 3.48; 95% CI: 1.79-6.77), whereas concordant pregnancies with SGA fetuses were associated with only mild PE (aRRR, 2.54; 95% CI: 1.33-4.88). Our results suggest that SGA is associated with the development of HDP/PE, while discordant growth is associated with the severity of PE. These associations need to be further investigated using estimated fetal weight (EFW).
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http://dx.doi.org/10.1111/jch.14257DOI Listing
July 2021

Live poultry feeding and trading network and the transmission of avian influenza A(H5N6) virus in a large city in China, 2014-2015.

Int J Infect Dis 2021 May 14;108:72-80. Epub 2021 May 14.

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian Province, People's Republic of China. Electronic address:

Objectives: To understand the transmission mechanisms of the avian influenza A(H5N6) virus.

Methods: This study explored the live poultry feeding and trading network (LPFTN) around Changsha city, China. Field epidemiological investigations were performed in Changsha to investigate the LPFTN with the environmental samples systematically collected during 2014-2015 to monitor and analyze the spread of the A(H5N6) virus. Two surveillance systems were also applied to find possible human cases of A(H5N6) infection.

Result: The information of all the 665 live poultry farming sites, five wholesale markets, and 223 retail markets in Changsha was collected to investigate the LPFTN. Moreover, about 840 environmental samples were systematically collected from the LPFTN during 2014-2015 to monitor the spread of the A(H5N6) virus, with 8.45% (71/840) positive for the N6 subtype. Furthermore, the full genome sequences of 10 A(H5N6) viruses detected from the environmental samples were obtained, which were then characterized and phylogenetically analyzed with the corresponding gene segments of the A(H5N6) virus obtained from GenBank, to determine the source of human infection.

Conclusion: It was demonstrated that the LPFTN provided a platform for the H5N6 transmission, and formed an infectious pool for the spread of the virus to humans.
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http://dx.doi.org/10.1016/j.ijid.2021.05.022DOI Listing
May 2021

Postconditioning attenuates myocardial ischemia-reperfusion injury by inhibiting complement activation and upregulation of miR-499.

Exp Ther Med 2021 Jul 26;22(1):684. Epub 2021 Apr 26.

Department of Cardiology, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.

The complement system plays a vital role in myocardial ischemia/reperfusion (I/R) injury. microRNA (miR)-499 is involved in the cardioprotection of ischemic postconditioning (IPostC). The present study aimed to study the role of the complement system and miR-499 in IPostC. Rat hearts were subjected to coronary ligation for 30 min, followed by reperfusion for 2 h. IPostC was introduced at the onset of reperfusion with three cycles of reperfusion for 30 sec and coronary artery occlusion for 30 sec. To study the role of miR-499 in IPostC, adeno-associated virus (AAV) vectors of miR-499-5p (AAV-miR-499-5p) and miR-499-5p-sponge (AAV-miR-499-5p-sponge) were transfected via tail vein injection, followed by IPostC protocols. Cardiac injury as well as the status of local and systemic complement activation and inflammation were assessed. IPostC significantly attenuated I/R-induced rat cardiomyocyte apoptosis and the myocardial infarct size. These beneficial effects were accompanied by decreased local and circulating complement component (C)3a and C5a levels, decreased inflammatory marker expression, decreased NF-κB signaling and increased cardiac miR-499 expression. AAV-miR-499-5p prevented local and systemic complement activation and inflammation as well as enhanced the cardioprotection of IPostC, whereas AAV-miR-499-5p-sponge produced the opposite effects. In summary, IPostC protected the rat myocardium against I/R injury, by inhibiting local and systemic complement activation; inflammation; NF-κB signaling; and upregulation of miR-499. As such, miR-499 may have a critical role in IPostC-mediated cardioprotection against I/R injury.
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http://dx.doi.org/10.3892/etm.2021.10116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111864PMC
July 2021

Efficient demodulation scheme based on adaptive clock extraction and mapping-sampling for a mobile OCC system.

Appl Opt 2021 Apr;60(12):3308-3313

An efficient demodulation scheme based on adaptive clock extraction and mapping-sampling is proposed and experimentally demonstrated for mobile optical camera communication (OCC) systems. For the proposed scheme, it can effectively improve the system performance in mobile OCC. The bit error rate (BER) performance of the proposed scheme and the other existing schemes are compared. The experimental results show that under the speed from 0.4 m/s to 0.7 m/s, it can significantly improve the system performance using the adaptive clock extraction and the mapping-sampling scheme in mobile OCC systems. Compared with the length estimation scheme, when the speed is 0.7 m/s, the BER can be improved from 9.14×10 to 3.16×10 at the exposure time of 1/12,000 s using the proposed scheme. In addition, the required memory and processing time of the proposed scheme are analyzed, which indicates that the proposed scheme has negligible influence on memory overhead and computational complexity.
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http://dx.doi.org/10.1364/AO.419897DOI Listing
April 2021

Expandable Technology Improves Clinical and Radiographic Outcomes of Minimally Invasive Lateral Lumbar Interbody Fusion for Degenerative Disc Disease.

Int J Spine Surg 2021 Feb 12;15(1):87-93. Epub 2021 Feb 12.

Musculoskeletal Education and Research Center, A Division of Globus Medical, Inc, Audubon, Pennsylvania.

Background: Static interbody spacers are standard of care for minimally invasive lateral lumbar interbody fusion (MIS LLIF). However, placement of large static interbody spacers typically requires multiple trialing, endplate preparation, and forceful impaction. A lateral expandable interbody spacer with adjustable lordosis can be inserted at a reduced height, to optimize the endplate-to-endplate fit. This study describes radiographic and clinical outcomes in patients treated using lateral titanium expandable interbody spacers with adjustable lordosis using MIS LLIF.

Methods: This is a single-surgeon, retrospective, institutional review board-exempt chart review of 24 consecutive patients who underwent MIS LLIF at 1-2 contiguous level(s) using expandable spacers with adjustable lordosis. Radiographic and clinical functional outcomes were collected and compared at preoperative and postoperative time points up to 24 months. Parametric and nonparametric tests were used when appropriate. Statistical results were significant if < .05.

Results: Twenty-four consecutive patients were evaluated with an average age of 57.8 ± 12.6 years; 45.8% were female. Visual analog scale for back pain improved by 7.3 ± 1.0 points, whereas Oswestry Disability Index scores improved by a mean of 67.5 ± 11.3 points at 24 months ( < .001). Lumbar lordosis improved by a mean of 6.3 ± 10.1° at 24 months ( < .001). There were 29 spinal levels, with 41.4% at L4-5 and 34.5% at L3-4. Anterior, middle, and posterior disc height significantly increased at 24 months by means of 4.5 ± 2.9 mm, 4.0 ± 2.8 mm, and 2.6 ± 1.9 mm, respectively ( < .001). Neuroforaminal height significantly improved by 3.3 ± 3.9 mm at 24 months ( < .001). Segmental lordosis improved by 3.6 ± 3.0° at 24 months.

Conclusions: This study showed significant positive clinical and radiographic outcomes for patients who underwent MIS LLIF using expandable interbody spacers with adjustable lordosis. Correction of sagittal alignment was achieved and maintained up to 2-year follow-up. The use of expandable spacers with adjustable lordosis was shown to be safe and effective in this cohort.

Level Of Evidence: 3.
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http://dx.doi.org/10.14444/8012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931745PMC
February 2021

MBNL1 Suppressed Cancer Metastatic of Skin Squamous Cell Carcinoma Via by TIAL1/MYOD1/Caspase-9/3 Signaling Pathways.

Technol Cancer Res Treat 2021 Jan-Dec;20:1533033820960755

Department of Pathology, Wuhan Central Hospital, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.

Objective: The incidence of skin squamous cell carcinoma (SSCC) has recently been increasing, with diverse clinical manifestations.SSCC could metastasize to lymph nodes or other organs, posing a great threat to life. The present study was designed to investigate the function and underlying mechanism of muscleblind-like protein 1 (MBNL1) in skin squamous cell carcinoma.

Methods: SCL-1 cell was used for vitro model and transfected with MBNL1 or siMBNL1 plasmids. MTT Assays, LDH activity ELISA, and Transwell chamber migration experiment were used to confirm the effects of MBNL1 on cell growth of SCL-1 cell. Western blot analysis was used to analyze the mechanism of MBNL1 in SCL-1 cell.

Results: Down-regulation of MBNL1 promoted cell metastasis of SSCC, while up-regulation of MBNL1 reduced cell metastasis of SSCC in vitro. Down-regulation of MBNL1 suppressed the protein expression of T cell intracellular antigen (TIAL1), myogenic determinant 1 (MyoD1) and Caspase-3 in vitro. Consistent with these observations, inhibition of TIAL1 or MYOD1 expression attenuated the effects of MBNL1 in SSCC.

Conclusion: The present study revealed that MBNL1 suppressed thecancer metastatic capacity of SSCC via by TIAL1/MYOD1/Caspase-3 signaling pathways.
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http://dx.doi.org/10.1177/1533033820960755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085367PMC
April 2021

Preparation and characterization of carboxymethylcellulose based citric acid cross-linked magnetic aerogel as an efficient dye adsorbent.

Int J Biol Macromol 2021 Jun 20;181:1030-1038. Epub 2021 Apr 20.

Applied Mechanics and Structure Safety Key Laboratory of Sichuan Province, School of Mechanics and Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031, China.

A low-cost, collectable, and efficient material is essential for adsorbing water pollution, such as dyes and heavy metal ions pollution. In this work, we proposed a novel strategy for the preparation of an efficient and collectable magnetic aerogel as adsorbent for dye. The magnetic aerogels were prepared from sodium carboxymethylcellulose (CMC) hydrogel using citric acid (CA) as the crosslinker, followed by vacuum freeze-drying technique to obtain aerogels. The effects of magnetic FeO nanoparticle contents on the adsorption properties of the aerogels were investigated. The results show that the as-prepared magnetic composite aerogels exhibit porous structure and display good adsorption and collectable performance for methylene blue (MB) in water with the removal rate of 97.5% in 6 h. The maximum compress strength and absorption capacity of the magnetic aerogel with 1 wt% FeO nanoparticle loading for MB is 0.13 MPa and 83.6 mg/g, respectively. Aerogels with FeO nanoparticles exhibited magnetism which enables the aerogels to easily collect. This excellent structure stability and collectability guarantees long-term integrity and floatability of the magnetic aerogels in water.
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http://dx.doi.org/10.1016/j.ijbiomac.2021.04.078DOI Listing
June 2021

A cobalt-based metal-organic framework and its derived material as sulfur hosts for aluminum-sulfur batteries with the chemical anchoring effect.

Phys Chem Chem Phys 2021 May;23(17):10326-10334

State Key Laboratory of Advanced Metallurgy, University of Science and Technology Beijing, Beijing 100083, P. R. China.

With the urgent need to explore high-performance electrochemical energy storage systems, rechargeable Al-ion batteries (AIBs) have attracted attention from researchers and engineers due to their traits, such as abundance and safety. Among all the issues waiting to be solved, the development of a reliable positive electrode material with high specific capacity is an absolute priority for the commercialization of AIBs. Sulfur has a natural advantage when used as the active material, and its theoretical specific capacity is as high as 1675 mA h g-1. MOFs and MOF-derived materials have been proved to be promising hosts for Li-S batteries. Herein, we report a novel Al-S battery system employing MOF (ZIF-67) and MOF-derived materials as sulfur host materials. After being chemically combined with sulfur, the composite still maintains its unique well-defined polyhedron morphology. The voltage hysteresis phenomenon is effectively alleviated with the aid of the host matrix. DFT calculations confirm that ZIF-67 and carbonized ZIF-67-700 polyhedrons can act as an anchor point towards sulfur (S8) and polysulfides (Al2S3, Al2S6, Al2S12, and Al2S18), preventing the detrimental dissolution and shuttle effect. These findings can enlighten future researchers regarding Al-S batteries and broaden the application of MOFs in the field of electrochemical energy storage systems.
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http://dx.doi.org/10.1039/d1cp01232kDOI Listing
May 2021

Evolution of Aerosol Optical Properties from Wood Smoke in Real Atmosphere Influenced by Burning Phase and Solar Radiation.

Environ Sci Technol 2021 05 20;55(9):5677-5688. Epub 2021 Apr 20.

Beijing Weather Modification Office, Beijing 100081, China.

Emissions of light-absorbing black carbon (BC) and organic aerosol (OA) from biomass burning are presented as complex mixtures, which introduce challenges in modeling their absorbing properties. In this study, we chose typical residential wood burning emission and used a novel designed chamber to investigate the early stage evolution of plumes from different burning phases under real ambient conditions. The detailed mixing state between BC and OA was evaluated, on the basis of which optical modeling was performed to achieve a closure of aerosol-absorbing properties. Intensive secondary OA (SOA) formation was observed under solar radiation. OA from flaming conditions showed a higher absorptivity than from smoldering conditions, as OA is mostly internally and externally mixed with BC, respectively. For flaming (smoldering), the imaginary refractive index of OA () was initially at 0.03 ± 0.01 (0.001) and 0.15 ± 0.02 (0.05 ± 0.02) at λ = 781 and 405 nm, respectively, with a half-decay time of 2-3 h in light but a <40% decrease under dark within 5 h. The production of less-absorbing SOA in the first 1-2 h and possible subsequent photobleaching of chromophores contributed to the decrease of . The enhanced abundance but decreased absorptivity of coatings on BC resulted in a relatively maintainable absorptivity of BC-containing particles during evolution.
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http://dx.doi.org/10.1021/acs.est.0c07569DOI Listing
May 2021

An Extracellular Matrix-Based Signature Associated With Immune Microenvironment Predicts the Prognosis and Therapeutic Responses of Patients With Oesophageal Squamous Cell Carcinoma.

Front Mol Biosci 2021 18;8:598427. Epub 2021 Mar 18.

Department of Pathology and Medical Research Center, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Evidence has suggested that the cancer-associated extracellular matrix (ECM) could be recognised as immune-related biomarkers that modulate tumour progression and expansion. However, the ECM-associated immune effect on esophageal squamous cell carcinoma (ESCC) prognosis and therapy has not been well characterised. In our study, we first constructed an ECM-related signature including four genes CST1, NELL2, ADAMTSL4, and ANGPTL7 by multivariate Cox regression analyses. This signature could serve as a marker to evaluate the prognosis of patients with ESCC and was successfully validated in testing and combined (training plus testing) cohorts. We also found that there were significant different therapeutic responses to chemotherapy and targeted drugs between the high-risk and low-risk groups of patients defined by the signature. Furthermore, the expression of four genes and immune function analysis suggested that this the tumour microenvironment. In conclusion, our findings demonstrated that the ECM-related signature might serve as an independent prognostic factor and provide a potential biomarker for chemotherapy responses for patients with ESCC.
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http://dx.doi.org/10.3389/fmolb.2021.598427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044946PMC
March 2021

Wrist-hand extension function recovery in spastic hemiplegia patient by botulinum toxin injection plus surface electromyography biofeedback therapy: A case report.

Medicine (Baltimore) 2021 Apr;100(14):e25252

Department of Rehabilitation Medicine, People's Hospital of Longhua, Shenzhen, Affiliated Hospital of Guangdong Medical University.

Rationale: Wrist-hand extension function rehabilitation is a vital and difficult part of hand function recovery in spastic stroke patients. Although botulinum toxin type A (BoNTA) injection plus post injection therapy was applied to the wrist-hand rehabilitation in previous reports, conclusion was inconsistent in promoting function. For this phenomenon, proper selection of patients for BoNTA injection and correct choice of post-injection intervention could be the crucial factors for the function recovery.

Patient Concerns: We reported a 46-year-old male suffered a spastic hemiplegia with wrist- hand extension deficit.

Diagnoses: Computed tomography showed cerebral hemorrhage in the left basal ganglia region.

Interventions: Four hundred units of BoNTA were injected into the spasticity flexors, and four-week post injection surface electromyography (sEMG) biofeedback therapy was applied to the patient.

Outcomes: The patient exhibited post-intervention improvement in wrist-hand extensors performance (strength, range of motion, sEMG signals), the flexors spasticity, and upper extremity function.

Lessons: The present case showed that 4-week of BoNTA injection plus sEMG biofeedback exercise improved the performance and function of wrist-hand extensors in the patient for short- and long-term. Proper selection of patients for BoNTA injection and correct choice of post injection exercise could play a vital role in the hand rehabilitation for patient with spastic hemiplegia.
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http://dx.doi.org/10.1097/MD.0000000000025252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036039PMC
April 2021

Aetiology of acute diarrhoea in children in Shanghai, 2015-2018.

PLoS One 2021 8;16(4):e0249888. Epub 2021 Apr 8.

Department of Infectious Diseases, Children's Hospital of Fudan University, Shanghai, China.

Diarrhoea remains a major cause of childhood morbidity and mortality worldwide. This study aimed to monitor the aetiology of acute diarrhoea in children in Shanghai. Paediatric outpatients with acute diarrhoea were enrolled in the study from Jan 2015 to Dec 2018. Faecal samples were collected for testing. Enteric bacteria were identified and typed by culture and serotyping, respectively. Enteric viruses were identified by real-time PCR. Enteric pathogens were identified in 1572 (58.4%) of the 2692 enrolled children with acute diarrhoea. Viruses were detected more frequently than bacteria (41.3% versus 25.0%). Nontyphoidal Salmonella spp. (NTS) was the most common (10.3%) bacteria isolated, followed by enteropathogenic Escherichia coli (EPEC) (6.5%), enteroaggregative Escherichia coli (EAEC) (6.2%), Campylobacter spp. (3.6%), enterotoxigenic Escherichia coli (ETEC) (1.1%), Shigella spp. (0.2%), and enterohemorrhagic Escherichia coli (EHEC) (0.1%). Rotavirus was the most common (16.0%) virus detected, followed by norovirus (15.5%), adenovirus (7.2%), sapovirus (3.0%) and astrovirus (2.7%). Rotavirus, norovirus and NTS were the major pathogens responsible for diarrhoea in Shanghainese children. Improving uptake of the rotavirus vaccine and strengthening foodborne-pathogen prevention will aid in reducing the burden of diarrhoeal disease in children in Shanghai.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0249888PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8031434PMC
April 2021

A method for the automatic detection of myopia in Optos fundus images based on deep learning.

Int J Numer Method Biomed Eng 2021 Jun 18;37(6):e3460. Epub 2021 Apr 18.

State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China.

Myopia detection is significant for preventing irreversible visual impairment and diagnosing myopic retinopathy. To improve the detection efficiency and accuracy, a Myopia Detection Network (MDNet) that combines the advantages of dense connection and Residual Squeeze-and-Excitation attention is proposed in this paper to automatically detect myopia in Optos fundus images. First, an automatic optic disc recognition method is applied to extract the Regions of Interest and remove the noise disturbances; then, data augmentation techniques are implemented to enlarge the data set and prevent overfitting; moreover, an MDNet composed of Attention Dense blocks is constructed to detect myopia in Optos fundus images. The results show that the Mean Absolute Error of the Spherical Equivalent detected by this network can reach 1.1150 D (diopter), which verifies the feasibility and applicability of this method for the automatic detection of myopia in Optos fundus images.
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http://dx.doi.org/10.1002/cnm.3460DOI Listing
June 2021

Towards an optimum colour preference metric for white light sources: a comprehensive investigation based on empirical data.

Opt Express 2021 Mar;29(5):6302-6319

Colour preference is a critical dimension for describing the colour quality of lighting and numerous metrics have been proposed. However, due to the variation amongst psychophysical studies, consensus has not been reached on the best approach to quantify colour preference. In this study, 25 typical colour quality metrics were comprehensively tested based on 39 groups of psychophysical data from 19 published visual studies. The experimental results showed that two combined metrics: the arithmetic mean of the gamut area index (GAI) and colour rendering index (CRI) and the colour quality index (CQI), a combination of the correlated colour temperature (CCT) and memory colour rendering index (MCRI), exhibit the best performance. Q in the colour quality scale (CQS) and MCRI also performed well in visual experiments of constant CCT but failed when CCT varied, which highlights the dependence of certain metrics on contextual lighting conditions. In addition, it was found that some weighted combinations of an absolute gamut-based metric and a colour fidelity metric exhibited superior performance in colour preference prediction. Consistent with such a result, a novel metric named MCPI (colour preference index based on meta-analysis) was proposed by fitting the large psychophysical dataset, and this achieved a significantly higher weighted average correlation coefficient between metric predictions and subjective preference ratings.
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http://dx.doi.org/10.1364/OE.413389DOI Listing
March 2021

An Amine-Assisted Ionic Monohydride Mechanism Enables Selective Alkyne -Semihydrogenation with Ethanol: From Elementary Steps to Catalysis.

J Am Chem Soc 2021 Mar 16;143(12):4824-4836. Epub 2021 Mar 16.

State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.

The selective synthesis of -alkenes in alkyne semihydrogenation relies on the reactivity difference of the catalysts toward the starting materials and the products. Here we report -selective semihydrogenation of alkynes with ethanol via a coordination-induced ionic monohydride mechanism. The EtOH-coordination-driven Cl dissociation in a pincer Ir(III) hydridochloride complex (NCP)IrHCl () forms a cationic monohydride, [(NCP)IrH(EtOH)]Cl, that reacts selectively with alkynes over the corresponding -alkenes, thereby overcoming competing thermodynamically dominant alkene - isomerization and overreduction. The challenge for establishing a catalytic cycle, however, lies in the alcoholysis step; the reaction of the alkyne insertion product (NCP)IrCl(vinyl) with EtOH does occur, but very slowly. Surprisingly, the alcoholysis does not proceed via direct protonolysis of the Ir-C(vinyl) bond. Instead, mechanistic data are consistent with an anion-involved alcoholysis pathway involving ionization of (NCP)IrCl(vinyl) via EtOH-for-Cl substitution and reversible protonation of Cl ion with an Ir(III)-bound EtOH, followed by β-H elimination of the ethoxy ligand and C(vinyl)-H reductive elimination. The use of an amine is key to the monohydride mechanism by promoting the alcoholysis. The -amine-EtOH catalytic system exhibits an unprecedented level of substrate scope, generality, and compatibility, as demonstrated by -selective reduction of all alkyne classes, including challenging enynes and complex polyfunctionalized molecules. Comparison with a cationic monohydride complex bearing a noncoordinating BArF ion elucidates the beneficial role of the Cl ion in controlling the stereoselectivity, and comparison between -amine-EtOH and -NaOBu-EtOH underscores the fact that this base variable, albeit in catalytic amounts, leads to different mechanisms and consequently different stereoselectivity.
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http://dx.doi.org/10.1021/jacs.1c01472DOI Listing
March 2021

Nanoparticle-mediated pulmonary drug delivery: state of the art towards efficient treatment of recalcitrant respiratory tract bacterial infections.

Drug Deliv Transl Res 2021 Aug 10;11(4):1634-1654. Epub 2021 Mar 10.

Center for Biopharmaceuticals and Biobarriers in Drug Delivery, Department of Pharmacy, University of Copenhagen, Universitetsparken 2, DK-2100, Copenhagen Ø, Denmark.

Recalcitrant respiratory tract infections caused by bacteria have emerged as one of the greatest health challenges worldwide. Aerosolized antimicrobial therapy is becoming increasingly attractive to combat such infections, as it allows targeted delivery of high drug concentrations to the infected organ while limiting systemic exposure. However, successful aerosolized antimicrobial therapy is still challenged by the diverse biological barriers in infected lungs. Nanoparticle-mediated pulmonary drug delivery is gaining increasing attention as a means to overcome the biological barriers and accomplish site-specific drug delivery by controlling release of the loaded drug(s) at the target site. With the aim to summarize emerging efforts in combating respiratory tract infections by using nanoparticle-mediated pulmonary delivery strategies, this review provides a brief introduction to the bacterial infection-related pulmonary diseases and the biological barriers for effective treatment of recalcitrant respiratory tract infections. This is followed by a summary of recent advances in design of inhalable nanoparticle-based drug delivery systems that overcome the biological barriers and increase drug bioavailability. Finally, challenges for the translation from exploratory laboratory research to clinical application are also discussed and potential solutions proposed.
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http://dx.doi.org/10.1007/s13346-021-00954-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7945609PMC
August 2021

Iron-Catalyzed Regio- and Stereoselective Hydrosilylation of 1,3-Enynes To Access 1,3-Dienylsilanes.

Org Lett 2021 03 10;23(6):2375-2379. Epub 2021 Mar 10.

Chang-Kung Chuang Institute, East China Normal University, Shanghai 200062, China.

A regio- and stereoselective hydrosilylation of 1,3-enynes with primary and secondary silanes to access 1,3-dienylsilanes is accomplished by employing an iron precatalyst bearing iminopyridine-oxazoline (IPO) ligand. The hydrosilylation proceeds via -addition of a Si-H bond to the alkyne group of 1,3-enynes, incorporating the silyl group at the site proximal to the alkene. The reaction features mild conditions, broad substrate scope, and good functional group tolerance. The synthetic utility was demonstrated by gram-scale reactions and further transformations.
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http://dx.doi.org/10.1021/acs.orglett.1c00670DOI Listing
March 2021

Niobium and Titanium Carbides (MXenes) as Superior Photothermal Supports for CO Photocatalysis.

ACS Nano 2021 Mar 24;15(3):5696-5705. Epub 2021 Feb 24.

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, PR China.

The conversion of CO into fuels and feedstock chemicals photothermal catalysis holds promise for efficient solar energy utilization to tackle the global energy shortage and climate change. Despite recent advances, it is of emerging interest to explore promising materials with excellent photothermal properties to boost the performance of photothermal CO catalysis. Here, we report the discovery of MXene materials as superior photothermal supports for metal nanoparticles. As a proof-of-concept study, we demonstrate that NbC and TiC, two typical MXene materials, can enhance the photothermal effect and thus boost the photothermal catalytic activity of Ni nanoparticles. A record CO conversion rate of 8.50 mol·g·h is achieved for NbC-nanosheet-supported Ni nanoparticles under intense illumination. Our study bridges the gap between photothermal MXene materials and photothermal CO catalysis toward more efficient solar-to-chemical energy conversions and stimulates the interest in MXene-supported metal nanoparticles for other heterogeneous catalytic reactions, particularly driven by sunlight.
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http://dx.doi.org/10.1021/acsnano.1c00990DOI Listing
March 2021

A call for universal criteria of high-intensity interval training in cardiac rehabilitation.

Eur J Prev Cardiol 2020 Jun 2. Epub 2020 Jun 2.

College of Kinesiology, Shenyang Sport University, Liaoning, Shenyang, China.

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http://dx.doi.org/10.1177/2047487320927618DOI Listing
June 2020