Zhenfeng Duan

Zhenfeng Duan

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Zhenfeng Duan

Publications by authors named "Zhenfeng Duan"

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Emerging next-generation sequencing-based discoveries for targeted osteosarcoma therapy.

Cancer Lett 2020 Apr 24;474:158-167. Epub 2020 Jan 24.

Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2020.01.020DOI Listing
April 2020

Chimeric antigen receptor T (CAR-T) cell immunotherapy for sarcomas: From mechanisms to potential clinical applications.

Cancer Treat Rev 2020 Jan 25;82:101934. Epub 2019 Nov 25.

Department of Orthopedic Surgery, Sarcoma Biology Laboratory, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2019.101934DOI Listing
January 2020

Aberrant CDK9 expression within chordoma tissues and the therapeutic potential of a selective CDK9 inhibitor LDC000067.

J Cancer 2020 1;11(1):132-141. Epub 2020 Jan 1.

Precision Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.

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http://dx.doi.org/10.7150/jca.35426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930393PMC
January 2020

Establishment and Characterization of a Recurrent Osteosarcoma Cell Line: OSA 1777.

J Orthop Res 2019 Nov 18. Epub 2019 Nov 18.

Department of Orthopedic Surgery, Sarcoma Biology Laboratory, David Geffen School of Medicine, University of California, Los Angeles, California.

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http://dx.doi.org/10.1002/jor.24528DOI Listing
November 2019

An Update on Circumventing Multidrug Resistance in Cancer by Targeting P-Glycoprotein.

Curr Cancer Drug Targets 2018 ;18(7):677-696

Department of Gynecology and Obstetrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.

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http://dx.doi.org/10.2174/1568009617666170623114524DOI Listing
October 2019

Role of cyclin-dependent kinases (CDKs) in hepatocellular carcinoma: Therapeutic potential of targeting the CDK signaling pathway.

Hepatol Res 2019 Oct 26;49(10):1097-1108. Epub 2019 May 26.

Precision Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

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http://dx.doi.org/10.1111/hepr.13353DOI Listing
October 2019

Transcriptional activation of CBFβ by CDK11 is necessary to promote osteosarcoma cell proliferation.

Cell Commun Signal 2019 Oct 14;17(1):125. Epub 2019 Oct 14.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, 615 Charles E. Young Dr. S, Los Angeles, CA, 90095, USA.

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http://dx.doi.org/10.1186/s12964-019-0440-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792216PMC
October 2019

Cancer Testis Antigens in Sarcoma: Expression, Function and Immunotherapeutic Application.

Cancer Lett 2019 Oct 18. Epub 2019 Oct 18.

Department of Orthopedic Surgery, Sarcoma Biology Laboratory, David Geffen School of Medicine at UCLA, 615 Charles E. Young Dr. South, Los Angeles, CA, 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2019.10.024DOI Listing
October 2019

Correction to: Transcriptional activation of CBFβ by CDK11 is necessary to promote osteosarcoma cell proliferation.

Cell Commun Signal 2019 Oct 29;17(1):138. Epub 2019 Oct 29.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, 615 Charles E. Young Dr. S, Los Angeles, CA, 90095, USA.

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http://dx.doi.org/10.1186/s12964-019-0462-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819566PMC
October 2019

Exosomes promote pre-metastatic niche formation in ovarian cancer.

Mol Cancer 2019 08 13;18(1):124. Epub 2019 Aug 13.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Zhengzhou, 450052, Henan, China.

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http://dx.doi.org/10.1186/s12943-019-1049-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691526PMC
August 2019

miR3609 sensitizes breast cancer cells to adriamycin by blocking the programmed death-ligand 1 immune checkpoint.

Exp Cell Res 2019 Jul 20;380(1):20-28. Epub 2019 Mar 20.

Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Sarcoma Biology Laboratory, UCLA Orthopaedic Surgery, Los Angeles, CA, 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2019.03.025DOI Listing
July 2019

Cyclin-dependent kinase 9 (CDK9) is a novel prognostic marker and therapeutic target in ovarian cancer.

FASEB J 2019 May 6;33(5):5990-6000. Epub 2019 Feb 6.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

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https://www.fasebj.org/doi/10.1096/fj.201801789RR
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http://dx.doi.org/10.1096/fj.201801789RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463912PMC
May 2019

Advances in immune checkpoint inhibitors for bone sarcoma therapy.

J Bone Oncol 2019 Apr 29;15:100221. Epub 2019 Jan 29.

Department of Orthopedic Surgery, Sarcoma Biology Laboratory, David Geffen School of Medicine, University of California, 615 Charles E. Young. Dr. South, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1016/j.jbo.2019.100221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365405PMC
April 2019

Targeting mutant TP53 as a potential therapeutic strategy for the treatment of osteosarcoma.

J Orthop Res 2019 03 12;37(3):789-798. Epub 2019 Feb 12.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, 90095.

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http://doi.wiley.com/10.1002/jor.24227
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http://dx.doi.org/10.1002/jor.24227DOI Listing
March 2019

Long non-coding RNA PVT1 promotes tumor progression by regulating the miR-143/HK2 axis in gallbladder cancer.

Mol Cancer 2019 03 2;18(1):33. Epub 2019 Mar 2.

Precision Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.

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http://dx.doi.org/10.1186/s12943-019-0947-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397746PMC
March 2019

Targeting regulation of cyclin dependent kinase 9 as a novel therapeutic strategy in synovial sarcoma.

J Orthop Res 2019 02 3;37(2):510-521. Epub 2019 Jan 3.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, David Geffen School of Medicine at University of California Los Angeles, 615 Charles E. Young Dr. S., Los Angeles, California, 90095.

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http://dx.doi.org/10.1002/jor.24189DOI Listing
February 2019

RNA sequencing (RNA-Seq) and its application in ovarian cancer.

Gynecol Oncol 2019 01 5;152(1):194-201. Epub 2018 Oct 5.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China; Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00908258183128
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http://dx.doi.org/10.1016/j.ygyno.2018.10.002DOI Listing
January 2019

Cyclin-dependent kinase 9 (CDK9) is a novel prognostic marker and therapeutic target in osteosarcoma.

EBioMedicine 2019 Jan 20;39:182-193. Epub 2018 Dec 20.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.12.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355967PMC
January 2019

MiR-139-5p is associated with poor prognosis and regulates glycolysis by repressing PKM2 in gallbladder carcinoma.

Cell Prolif 2018 Dec 13;51(6):e12510. Epub 2018 Aug 13.

Precision Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

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http://dx.doi.org/10.1111/cpr.12510DOI Listing
December 2018

From genomics to metabolomics: emerging metastatic biomarkers in osteosarcoma.

Cancer Metastasis Rev 2018 12;37(4):719-731

Department of Orthopaedic Surgery, Sarcoma Biology Laboratory, David Geffen School of Medicine at UCLA, 615 Charles E. Young Dr. S, Los Angeles, CA, 90095, USA.

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http://dx.doi.org/10.1007/s10555-018-9763-8DOI Listing
December 2018

Application of liquid biopsy in bone and soft tissue sarcomas: Present and future.

Cancer Lett 2018 12 14;439:66-77. Epub 2018 Sep 14.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, David Geffen School of Medicine at University of Los Angeles, Los Angeles, CA, 90095, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043835183056
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http://dx.doi.org/10.1016/j.canlet.2018.09.012DOI Listing
December 2018

Author Correction: Androgen receptor is a potential novel prognostic marker and oncogenic target in osteosarcoma with dependence on CDK11.

Sci Rep 2018 Aug 9;8(1):12107. Epub 2018 Aug 9.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Jackson 1115, Boston, Massachusetts, 02114, USA.

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http://www.nature.com/articles/s41598-018-30644-x
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http://dx.doi.org/10.1038/s41598-018-30644-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085288PMC
August 2018

Expression and Clinical Implication of Autophagy-Associated Protein p62 in Osteosarcoma.

Oncology 2018 4;95(1):52-60. Epub 2018 Apr 4.

Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.

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http://dx.doi.org/10.1159/000487437DOI Listing
July 2018

CRISPR-Cas9-Mediated Silencing of CD44 in Human Highly Metastatic Osteosarcoma Cells.

Cell Physiol Biochem 2018 16;46(3):1218-1230. Epub 2018 Apr 16.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, David Geffen School of Medicine at University of Los Angeles, Los Angeles, California, USA.

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http://dx.doi.org/10.1159/000489072DOI Listing
July 2018

Expression and role of autophagy-associated p62 (SQSTM1) in multidrug resistant ovarian cancer.

Gynecol Oncol 2018 07 24;150(1):143-150. Epub 2018 Apr 24.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China; Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2018.04.557DOI Listing
July 2018

CDK4 expression in chordoma: A potential therapeutic target.

J Orthop Res 2018 06 22;36(6):1581-1589. Epub 2017 Dec 22.

UCLA Orthopaedic Surgery, Sarcoma Biology Laboratory, 615 Charles E Young Dr. South, Biomedical Sciences Research Building, Room 410, Los Angeles, CA 90095.

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http://dx.doi.org/10.1002/jor.23819DOI Listing
June 2018

Expression and therapeutic implications of cyclin-dependent kinase 4 (CDK4) in osteosarcoma.

Biochim Biophys Acta Mol Basis Dis 2018 May 13;1864(5 Pt A):1573-1582. Epub 2018 Feb 13.

Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, People's Republic of China; Sarcoma Biology Laboratory, UCLA Orthopaedic Surgery, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2018.02.004DOI Listing
May 2018

HER4 promotes cell survival and chemoresistance in osteosarcoma via interaction with NDRG1.

Biochim Biophys Acta Mol Basis Dis 2018 May 8;1864(5 Pt A):1839-1849. Epub 2018 Mar 8.

Department of Orthopedics, Shanghai General Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, China; Shanghai Bone Tumor Institution, Shanghai, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2018.03.008DOI Listing
May 2018

Inhibition of cyclin-dependent kinase 4 as a potential therapeutic strategy for treatment of synovial sarcoma.

Cell Death Dis 2018 05 1;9(5):446. Epub 2018 May 1.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, David Geffen School of Medicine at University of Los Angeles, Los Angeles, CA, 90095, USA.

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http://dx.doi.org/10.1038/s41419-018-0474-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906661PMC
May 2018

Targeting DYRK1B suppresses the proliferation and migration of liposarcoma cells.

Oncotarget 2018 Mar 28;9(17):13154-13166. Epub 2017 Nov 28.

Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-6902, USA.

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http://dx.doi.org/10.18632/oncotarget.22743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862568PMC
March 2018

Advances in chromosomal translocations and fusion genes in sarcomas and potential therapeutic applications.

Cancer Treat Rev 2018 Feb 6;63:61-70. Epub 2017 Dec 6.

Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, 615 Charles E. Young. Dr. South, Los Angeles, CA 90095-6902, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2017.12.001DOI Listing
February 2018

Advances in sarcoma gene mutations and therapeutic targets.

Cancer Treat Rev 2018 Jan 11;62:98-109. Epub 2017 Nov 11.

UCLA Orthopaedic Surgery, Sarcoma Biology Laboratory, 615 Charles E Young Dr. South, Biomedical Sciences Research Building, Room 410, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2017.11.001DOI Listing
January 2018

Novel strategies to prevent the development of multidrug resistance (MDR) in cancer.

Oncotarget 2017 Oct 12;8(48):84559-84571. Epub 2017 Jul 12.

Department of Gynecologic Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, People's Republic of China.

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http://dx.doi.org/10.18632/oncotarget.19187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663620PMC
October 2017

Expression and Therapeutic Potential of SOX9 in Chordoma.

Clin Cancer Res 2017 Sep 12;23(17):5176-5186. Epub 2017 Jun 12.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-0177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581713PMC
September 2017

Therapeutic applications of histone deacetylase inhibitors in sarcoma.

Cancer Treat Rev 2017 Sep 6;59:33-45. Epub 2017 Jul 6.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Jackson 1115, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2017.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581728PMC
September 2017

Regulation of microRNAs function by circular RNAs in human cancer.

Oncotarget 2017 Sep 4;8(38):64622-64637. Epub 2017 Aug 4.

Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China.

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http://dx.doi.org/10.18632/oncotarget.19930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610031PMC
September 2017

Noncoding RNA in drug resistant sarcoma.

Oncotarget 2017 Sep 6;8(40):69086-69104. Epub 2017 Jul 6.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, 02114, USA.

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http://dx.doi.org/10.18632/oncotarget.19029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620323PMC
September 2017

The Roles of Sox Family Genes in Sarcoma.

Curr Drug Targets 2016 ;17(15):1761-1772

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, 100 Blossom St. Jackson 1115, Boston, MA 02114, USA.

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http://dx.doi.org/10.2174/1389450117666160502145311DOI Listing
August 2017

Autophagy as a potential target for sarcoma treatment.

Biochim Biophys Acta Rev Cancer 2017 Aug 24;1868(1):40-50. Epub 2017 Feb 24.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Jackson 1115, Boston, MA 02114, USA.. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2017.02.004DOI Listing
August 2017

Application of metabolomics in sarcoma: From biomarkers to therapeutic targets.

Crit Rev Oncol Hematol 2017 08 13;116:1-10. Epub 2017 May 13.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Jackson 1115, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.critrevonc.2017.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527996PMC
August 2017

Three-dimensional (3D) culture in sarcoma research and the clinical significance.

Biofabrication 2017 Aug 3;9(3):032003. Epub 2017 Aug 3.

Department of Orthopedics, The Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, Henan 450008, People's Republic of China. Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Jackson 1115, Boston, MA 02114, United States of America.

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http://dx.doi.org/10.1088/1758-5090/aa7fdbDOI Listing
August 2017

Inhibition of CDK4 sensitizes multidrug resistant ovarian cancer cells to paclitaxel by increasing apoptosiss.

Cell Oncol (Dordr) 2017 Jun 27;40(3):209-218. Epub 2017 Feb 27.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom St, Jackson 1115, Boston, MA, 02114, USA.

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http://link.springer.com/10.1007/s13402-017-0316-x
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http://dx.doi.org/10.1007/s13402-017-0316-xDOI Listing
June 2017

Aberration of Promoter Methylation in Chondrosarcoma.

Anticancer Res 2017 06;37(6):2939-2945

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, U.S.A.

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http://ar.iiarjournals.org/content/37/6/2939.abstract
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http://dx.doi.org/10.21873/anticanres.11647DOI Listing
June 2017

Targeting programmed cell death ligand 1 by CRISPR/Cas9 in osteosarcoma cells.

Oncotarget 2017 May;8(18):30276-30287

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston 02114, Massachusetts, USA.

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http://dx.doi.org/10.18632/oncotarget.16326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444742PMC
May 2017

Wnt inhibitory factor 1 (WIF1) methylation and its association with clinical prognosis in patients with chondrosarcoma.

Sci Rep 2017 05 8;7(1):1580. Epub 2017 May 8.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1038/s41598-017-01763-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431504PMC
May 2017

Facial Layer-by-Layer Engineering of Upconversion Nanoparticles for Gene Delivery: Near-Infrared-Initiated Fluorescence Resonance Energy Transfer Tracking and Overcoming Drug Resistance in Ovarian Cancer.

ACS Appl Mater Interfaces 2017 Mar 21;9(9):7941-7949. Epub 2017 Feb 21.

Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University , Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acsami.6b15321DOI Listing
March 2017

Androgen receptor is a potential novel prognostic marker and oncogenic target in osteosarcoma with dependence on CDK11.

Sci Rep 2017 03 6;7:43941. Epub 2017 Mar 6.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Jackson 1115, Boston, Massachusetts 02114USA.

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http://dx.doi.org/10.1038/srep43941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338289PMC
March 2017

Potentials of Long Noncoding RNAs (LncRNAs) in Sarcoma: From Biomarkers to Therapeutic Targets.

Int J Mol Sci 2017 Mar 29;18(4). Epub 2017 Mar 29.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Jackson 1115, Boston, MA 02114, USA.

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http://dx.doi.org/10.3390/ijms18040731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412317PMC
March 2017

Regulation of microRNA-1 (miR-1) expression in human cancer.

Biochim Biophys Acta Gene Regul Mech 2017 Feb 5;1860(2):227-232. Epub 2016 Dec 5.

Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, PR China; Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2016.12.004DOI Listing
February 2017

miR-15b modulates multidrug resistance in human osteosarcoma in vitro and in vivo.

Mol Oncol 2017 02 24;11(2):151-166. Epub 2016 Oct 24.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, MA, USA.

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http://doi.wiley.com/10.1002/1878-0261.12015
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http://dx.doi.org/10.1002/1878-0261.12015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300234PMC
February 2017

IAPP modulates cellular autophagy, apoptosis, and extracellular matrix metabolism in human intervertebral disc cells.

Cell Death Discov 2017 30;3:16107. Epub 2017 Jan 30.

Department of Orthopaedic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430022, China.

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http://dx.doi.org/10.1038/cddiscovery.2016.107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5280875PMC
January 2017

Novel mechanisms and approaches to overcome multidrug resistance in the treatment of ovarian cancer.

Biochim Biophys Acta 2016 12 4;1866(2):266-275. Epub 2016 Oct 4.

Department of Gynecologic Oncology, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Zhengzhou 450052, People's Republic of China; Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Jackson 1115, Boston, MA 02114, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2016.10.001DOI Listing
December 2016

Targeting ABCB1 (MDR1) in multi-drug resistant osteosarcoma cells using the CRISPR-Cas9 system to reverse drug resistance.

Oncotarget 2016 Dec;7(50):83502-83513

Sarcoma Biology Laboratory, Department of Orthopaedic surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.18632/oncotarget.13148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347784PMC
December 2016

Matrine induces cell cycle arrest and apoptosis with recovery of the expression of miR-126 in the A549 non-small cell lung cancer cell line.

Mol Med Rep 2016 Nov 20;14(5):4042-4048. Epub 2016 Sep 20.

Department of Clinical Pharmacology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.

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http://dx.doi.org/10.3892/mmr.2016.5753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101874PMC
November 2016

Aberrant DNA methylations in chondrosarcoma.

Epigenomics 2016 11 30;8(11):1519-1525. Epub 2016 Sep 30.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital & Harvard Medical School, 55 Fruit Street, Jackson 1115, Boston, MA 02114, USA.

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http://dx.doi.org/10.2217/epi-2016-0071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289043PMC
November 2016

MicroRNA-7 regulates IL-1β-induced extracellular matrix degeneration by targeting GDF5 in human nucleus pulposus cells.

Biomed Pharmacother 2016 Oct 30;83:1414-1421. Epub 2016 Aug 30.

Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Road, No. 1277,Wuhan 430022, China. Electronic address:

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http://dx.doi.org/10.1016/j.biopha.2016.08.062DOI Listing
October 2016

Evaluation of P-glycoprotein (Pgp) expression in human osteosarcoma by high-throughput tissue microarray.

J Orthop Res 2016 09 2;34(9):1606-12. Epub 2016 Feb 2.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, 02114.

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http://dx.doi.org/10.1002/jor.23173DOI Listing
September 2016

The roles and implications of exosomes in sarcoma.

Cancer Metastasis Rev 2016 09;35(3):377-90

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Jackson 1115, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1007/s10555-016-9630-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037004PMC
September 2016

CD151-mediated adhesion is crucial to osteosarcoma pulmonary metastasis.

Oncotarget 2016 Sep;7(37):60623-60638

Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.

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http://www.oncotarget.com/fulltext/11380
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http://dx.doi.org/10.18632/oncotarget.11380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312406PMC
September 2016

Polymeric nanoparticle-based delivery of microRNA-199a-3p inhibits proliferation and growth of osteosarcoma cells.

Int J Nanomedicine 2015 15;10:2913-24. Epub 2015 Apr 15.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.2147/IJN.S79143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404938PMC
August 2016

Clinical and biological significance of PIM1 kinase in osteosarcoma.

J Orthop Res 2016 07 31;34(7):1185-94. Epub 2015 Dec 31.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Jackson 1115, Boston, Massachusetts 02114.

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http://dx.doi.org/10.1002/jor.23134DOI Listing
July 2016

Cyclin-Dependent Kinase 11 (CDK11) Is Required for Ovarian Cancer Cell Growth In Vitro and In Vivo, and Its Inhibition Causes Apoptosis and Sensitizes Cells to Paclitaxel.

Mol Cancer Ther 2016 07 20;15(7):1691-701. Epub 2016 May 20.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1535-7163.MCT-16-0032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936930PMC
July 2016

The Involvement of Protease Nexin-1 (PN1) in the Pathogenesis of Intervertebral Disc (IVD) Degeneration.

Sci Rep 2016 07 27;6:30563. Epub 2016 Jul 27.

Department of Orthopaedic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

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http://dx.doi.org/10.1038/srep30563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962060PMC
July 2016

The roles and therapeutic potential of cyclin-dependent kinases (CDKs) in sarcoma.

Cancer Metastasis Rev 2016 06;35(2):151-63

Department of Orthopaedic Surgery, Sarcoma Biology Laboratory, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Jackson 1115, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1007/s10555-015-9601-1DOI Listing
June 2016

CSPG4 as a prognostic biomarker in chordoma.

Spine J 2016 06 9;16(6):722-7. Epub 2015 Dec 9.

Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.spinee.2015.11.059DOI Listing
June 2016

Overexpression of EZH2 is associated with the poor prognosis in osteosarcoma and function analysis indicates a therapeutic potential.

Oncotarget 2016 Jun;7(25):38333-38346

Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, People's Republic of China.

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http://dx.doi.org/10.18632/oncotarget.9518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122393PMC
June 2016

The emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancer.

Oncotarget 2016 Jun;7(26):40846-40859

Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People's Republic of China.

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http://dx.doi.org/10.18632/oncotarget.8519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130049PMC
June 2016

Pharmacokinetics and tolerability of NSC23925b, a novel P-glycoprotein inhibitor: preclinical study in mice and rats.

Sci Rep 2016 05 9;6:25659. Epub 2016 May 9.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1038/srep25659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860631PMC
May 2016

Development and potential applications of CRISPR-Cas9 genome editing technology in sarcoma.

Cancer Lett 2016 Apr 21;373(1):109-118. Epub 2016 Jan 21.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Jackson 1115, Boston, MA 02114, United States. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2016.01.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772675PMC
April 2016

Targeting EZH2-mediated methylation of H3K27 inhibits proliferation and migration of Synovial Sarcoma in vitro.

Sci Rep 2016 04 29;6:25239. Epub 2016 Apr 29.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, United States.

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http://dx.doi.org/10.1038/srep25239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850444PMC
April 2016

Targeted cancer therapy; nanotechnology approaches for overcoming drug resistance.

Curr Med Chem 2015 ;22(11):1335-47

Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Jackson Building Room 1115, Boston, MA 02114, USA.

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http://dx.doi.org/10.2174/0929867322666150209151851DOI Listing
February 2016

NVP-TAE684 reverses multidrug resistance (MDR) in human osteosarcoma by inhibiting P-glycoprotein (PGP1) function.

Br J Pharmacol 2016 Feb 15;173(3):613-26. Epub 2016 Jan 15.

Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/bph.13395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728419PMC
February 2016

p53 overexpression increases chemosensitivity in multidrug-resistant osteosarcoma cell lines.

Cancer Chemother Pharmacol 2016 Feb 23;77(2):349-56. Epub 2015 Dec 23.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, 100 Blossom St., Jackson 1115, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1007/s00280-015-2944-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749432PMC
February 2016

Targeting protein kinases to reverse multidrug resistance in sarcoma.

Cancer Treat Rev 2016 Feb 8;43:8-18. Epub 2015 Dec 8.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Jackson 1115, Boston, MA 02114, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2015.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735639PMC
February 2016

In vitro effects of mitomycin C on the proliferation of the non-small-cell lung cancer line A549.

Int J Clin Exp Med 2015 15;8(11):20516-23. Epub 2015 Nov 15.

Department of Clinical Pharmacology, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723813PMC
February 2016

Near-infrared light activated delivery platform for cancer therapy.

Adv Colloid Interface Sci 2015 Dec 14;226(Pt B):123-37. Epub 2015 Oct 14.

Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Harvard Medical School, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cis.2015.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679704PMC
December 2015

The emerging roles and therapeutic potential of microRNAs (miRs) in liposarcoma.

Discov Med 2015 Nov;20(111):311-24

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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November 2015

Nsc23925 prevents the development of paclitaxel resistance by inhibiting the introduction of P-glycoprotein and enhancing apoptosis.

Int J Cancer 2015 Oct 5;137(8):2029-39. Epub 2015 May 5.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1002/ijc.29574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529776PMC
October 2015

MicroRNA-1 (miR-1) inhibits gastric cancer cell proliferation and migration by targeting MET.

Tumour Biol 2015 Sep 1;36(9):6715-23. Epub 2015 Apr 1.

Department of Clinical Pharmacology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People's Republic of China.

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http://dx.doi.org/10.1007/s13277-015-3358-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644207PMC
September 2015

Rhabdomyosarcoma: Advances in Molecular and Cellular Biology.

Sarcoma 2015 1;2015:232010. Epub 2015 Sep 1.

Department of Orthopaedic Surgery, Massachusetts General Hospital, 100 Blossom Street, Boston, MA 02114, USA ; Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, 100 Blossom Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1155/2015/232010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569767PMC
September 2015

Cluster of Differentiation 44 Targeted Hyaluronic Acid Based Nanoparticles for MDR1 siRNA Delivery to Overcome Drug Resistance in Ovarian Cancer.

Pharm Res 2015 Jun 17;32(6):2097-109. Epub 2014 Dec 17.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom St, Jackson 1115, Boston, Massachusetts, 02114, USA.

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http://link.springer.com/10.1007/s11095-014-1602-1
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http://dx.doi.org/10.1007/s11095-014-1602-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425596PMC
June 2015

CD44 is a direct target of miR-199a-3p and contributes to aggressive progression in osteosarcoma.

Sci Rep 2015 Jun 16;5:11365. Epub 2015 Jun 16.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.

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http://www.nature.com/articles/srep11365
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http://dx.doi.org/10.1038/srep11365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468826PMC
June 2015

Expression of programmed cell death ligand 1 (PD-L1) and prevalence of tumor-infiltrating lymphocytes (TILs) in chordoma.

Oncotarget 2015 May;6(13):11139-49

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, Jackson, Boston, Massachusetts, USA.

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http://www.oncotarget.com/fulltext/3576
Publisher Site
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484445PMC
http://dx.doi.org/10.18632/oncotarget.3576DOI Listing
May 2015

Cyclin-dependent kinase 11(p110) (CDK11(p110)) is crucial for human breast cancer cell proliferation and growth.

Sci Rep 2015 May 20;5:10433. Epub 2015 May 20.

Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Zhengzhou 450052, China.

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http://dx.doi.org/10.1038/srep10433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438429PMC
May 2015

NSC23925 prevents the emergence of multidrug resistance in ovarian cancer in vitro and in vivo.

Gynecol Oncol 2015 Apr 10;137(1):134-42. Epub 2015 Feb 10.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2015.02.002DOI Listing
April 2015

Decreased expression and activation of Stat3 in severe preeclampsia.

J Mol Histol 2015 Apr 10;46(2):205-19. Epub 2015 Mar 10.

Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, 7 Kangfuqian Street, Zhengzhou, 450052, Henan Province, China,

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http://dx.doi.org/10.1007/s10735-015-9613-8DOI Listing
April 2015

Up-regulation of CD44 in the development of metastasis, recurrence and drug resistance of ovarian cancer.

Oncotarget 2015 Apr;6(11):9313-26

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496219PMC
http://dx.doi.org/10.18632/oncotarget.3220DOI Listing
April 2015

MicroRNA-155 expression is independently predictive of outcome in chordoma.

Oncotarget 2015 Apr;6(11):9125-39

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496207PMC
http://dx.doi.org/10.18632/oncotarget.3273DOI Listing
April 2015

Inkjet printing of upconversion nanoparticles for anti-counterfeit applications.

Nanoscale 2015 Mar;7(10):4423-31

The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P.R. China.

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http://dx.doi.org/10.1039/c4nr06944gDOI Listing
March 2015

Targeting CDK11 in osteosarcoma cells using the CRISPR-Cas9 system.

J Orthop Res 2015 Feb 27;33(2):199-207. Epub 2014 Oct 27.

Department of Orthopaedic Surgery, Sarcoma Biology Laboratory, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Jackson 1115, 02114, Boston, Massachusetts; Department of Orthopaedic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jie Fang Avenue, 430022, Wuhan, China.

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http://doi.wiley.com/10.1002/jor.22745
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http://dx.doi.org/10.1002/jor.22745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304907PMC
February 2015

MDR1 siRNA loaded hyaluronic acid-based CD44 targeted nanoparticle systems circumvent paclitaxel resistance in ovarian cancer.

Sci Rep 2015 Feb 17;5:8509. Epub 2015 Feb 17.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.

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http://dx.doi.org/10.1038/srep08509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330541PMC
February 2015

Distance-dependent plasmon-enhanced fluorescence of upconversion nanoparticles using polyelectrolyte multilayers as tunable spacers.

Sci Rep 2015 Jan 14;5:7779. Epub 2015 Jan 14.

1] The Key Laboratory of Biomedical Information Engineering, Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P.R. China [2] Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, P.R. China [3] Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Harvard Medical School, MA 02114, USA.

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http://dx.doi.org/10.1038/srep07779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379003PMC
January 2015

A-770041 reverses paclitaxel and doxorubicin resistance in osteosarcoma cells.

BMC Cancer 2014 Sep 19;14:681. Epub 2014 Sep 19.

Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, 100 Blossom St,, Jackson 1115, Boston 02114, MA, USA.

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http://dx.doi.org/10.1186/1471-2407-14-681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177239PMC
September 2014

Targeting programmed cell death ligand 1 in osteosarcoma: an auto-commentary on therapeutic potential.

Oncoimmunology 2014;3(8):e954467. Epub 2014 Aug 3.

Sarcoma Biology Laboratory; Center for Sarcoma and Connective Tissue Oncology; Massachusetts General Hospital ; Boston, MA USA.

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http://dx.doi.org/10.4161/21624011.2014.954467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292524PMC
August 2014