Zhanyun Fan

Zhanyun Fan

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Zhanyun Fan

Zhanyun Fan

Publications by authors named "Zhanyun Fan"

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A flow cytometry-based assay reveals that formation of apolipoprotein E (ApoE)-amyloid beta complexes depends on ApoE isoform and cell type.

J Biol Chem 2018 08 27;293(34):13247-13256. Epub 2018 Jun 27.

From the Alzheimer's Disease Research Laboratory, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129

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http://dx.doi.org/10.1074/jbc.RA117.001388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109911PMC
August 2018

Characterization of TauC3 antibody and demonstration of its potential to block tau propagation.

PLoS One 2017 22;12(5):e0177914. Epub 2017 May 22.

Massachusetts General Hospital, Harvard Medical School, Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Charlestown, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0177914PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439699PMC
September 2017

Isoform- and cell type-specific structure of apolipoprotein E lipoparticles as revealed by a novel Forster resonance energy transfer assay.

J Biol Chem 2017 09 6;292(36):14720-14729. Epub 2017 Jul 6.

From the Alzheimer's Disease Research Laboratory, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129 and

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http://dx.doi.org/10.1074/jbc.M117.784264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592654PMC
September 2017

Formation, release, and internalization of stable tau oligomers in cells.

J Neurochem 2016 12 10;139(6):1163-1174. Epub 2016 Nov 10.

Department of Neurology, Massachusetts General Hospital, MassGeneral Institute of Neurodegenerative Diseases (MIND), Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1111/jnc.13866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283951PMC
December 2016

Tailored transgene expression to specific cell types in the central nervous system after peripheral injection with AAV9.

Mol Ther Methods Clin Dev 2016 7;3:16081. Epub 2016 Dec 7.

MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital and Harvard Medical School , Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1038/mtm.2016.81DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142512PMC
December 2016

Direct visualization of CHIP-mediated degradation of alpha-synuclein in vivo: implications for PD therapeutics.

PLoS One 2014 24;9(3):e92098. Epub 2014 Mar 24.

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0092098PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963877PMC
January 2015

Direct detection of alpha synuclein oligomers in vivo.

Acta Neuropathol Commun 2013 May 9;1. Epub 2013 May 9.

MassGeneral Institute for Neurodegenerative Disease, Department Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1186/2051-5960-1-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776213PMC
May 2013

Inhibition of the NFAT pathway alleviates amyloid β neurotoxicity in a mouse model of Alzheimer's disease.

J Neurosci 2012 Feb;32(9):3176-92

Massachusetts General Hospital, Department of Neurology/Alzheimer's Disease Research Laboratory, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.6439-11.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296329PMC
February 2012

Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of α-synuclein.

J Neurosci 2011 Oct;31(41):14508-20

Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.1560-11.2
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http://dx.doi.org/10.1523/JNEUROSCI.1560-11.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587176PMC
October 2011

Characterization of oligomer formation of amyloid-beta peptide using a split-luciferase complementation assay.

J Biol Chem 2011 Aug 7;286(31):27081-91. Epub 2011 Jun 7.

Department of Neurology, Alzheimer's Disease Research Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1074/jbc.M111.257378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149301PMC
August 2011

Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio.

PLoS One 2009 Nov 18;4(11):e7893. Epub 2009 Nov 18.

Alzheimer Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, Massachusetts, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007893PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773935PMC
November 2009

Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport.

J Neurochem 2009 Oct 3;111(2):417-27. Epub 2009 Aug 3.

MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2009.06316.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831412PMC
October 2009

Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease.

J Neuropathol Exp Neurol 2009 May;68(5):515-24

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129-4404, USA.

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http://dx.doi.org/10.1097/NEN.0b013e3181a24b53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753269PMC
May 2009