Publications by authors named "Zhan Shi"

323 Publications

An electrochemical modification strategy to fabricate NiFeCuPt polymetallic carbon matrices on nickel foam as stable electrocatalysts for water splitting.

Chem Sci 2022 Aug 5;13(30):8876-8884. Epub 2022 Jul 5.

State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University Changchun 130012 P. R. China

Electrochemical modification is a mild and economical way to prepare electrocatalytic materials with abundant active sites and high atom efficiency. In this work, a stable NiFeCuPt carbon matrix deposited on nickel foam (NFFeCuPt) was fabricated with an extremely low Pt load (∼28 μg cm) using one-step electrochemical co-deposition modification, and it serves as a bifunctional catalyst for overall water splitting and achieves 100 mA cm current density at a low cell voltage of 1.54 V in acidic solution and 1.63 V in alkaline solution, respectively. In addition, a novel electrolyte was developed to stabilize the catalyst under acidic conditions, which provides inspiration for the development of highly efficient, highly stable, and cost-effective ways to synthesize electrocatalysts.
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http://dx.doi.org/10.1039/d2sc02845jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350615PMC
August 2022

Nasopharyngeal Warthin's Tumors: A Case Report and Minireview.

Authors:
Zhan Shi Xiang Zhai

Ear Nose Throat J 2022 Aug 13:1455613221119060. Epub 2022 Aug 13.

Department of Otolaryngology, 117918Tianjin Huanhu Hospital, Tianjin, China.

Warthin's tumors of the head and neck are more common in the parotid and salivary glands and are extremely rare in the nasopharynx. This paper reports the clinical data of a patient with a nasopharyngeal Warthin's tumor and posterior nostril atresia who underwent nasal endoscopic nasal mass resection combined with posterior nostriphoplasty, and the patient has no tumor recurrence during the postoperative follow-up of until 14 months. This case report, combined with a literature review, conducted an in-depth analysis of nasopharyngeal Warthin's tumors to enable more otolaryngology specialists to deepen their understanding of such diseases.
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http://dx.doi.org/10.1177/01455613221119060DOI Listing
August 2022

A Spatial Attention Guided Deep Learning System for Prediction of Pathological Complete Response Using Breast Cancer Histopathology Images.

Bioinformatics 2022 Aug 13. Epub 2022 Aug 13.

Department of Mathematics and Statistics and Computer Science, Georgia State University, GA, USA.

Motivation: Predicting pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in triple-negative breast cancer (TNBC) patients accurately is direly needed for clinical decision making. pCR is also regarded as a strong predictor of overall survival. In this work, we propose a deep learning system to predict pCR to NAC based on serial pathology images stained with hematoxylin and eosin (H&E) and two immunohistochemical biomarkers (Ki67 and PHH3). To support human prior domain knowledge based guidance and enhance interpretability of the deep learning system, we introduce a human knowledge derived spatial attention mechanism to inform deep learning models of informative tissue areas of interest. For each patient, three serial breast tumor tissue sections from biopsy blocks were sectioned, stained in three different stains, and integrated. The resulting comprehensive attention information from the image triplets is used to guide our prediction system for prognostic tissue regions.

Results: The experimental dataset consists of 26,419 pathology image patches of 1,000×1,000 pixels from 73 TNBC patients treated with NAC. Image patches from randomly selected 43 patients are used as a training dataset and images patches from the rest 30 are used as a testing dataset. By the maximum voting from patch-level results, our proposed model achieves a 93% patient-level accuracy, outperforming baselines and other state-of-the-art systems, suggesting its high potential for clinical decision making.

Availability: The codes, the documentation, and example data are available on an open source at: https://github.com/jkonglab/PCR_Prediction_Serial_WSIs_biomarkers.
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http://dx.doi.org/10.1093/bioinformatics/btac558DOI Listing
August 2022

IGF-1 Promotes Epithelial-Mesenchymal Transition of Lens Epithelial Cells That Is Conferred by miR-3666 Loss.

Contrast Media Mol Imaging 2022 14;2022:5383146. Epub 2022 Jul 14.

The First Affiliated Hospital of Harbin Medical University, Ophthalmology Department, Harbin, China.

The abnormal proliferation, migration, and epithelial-mesenchymal transformation (EMT) of lens epithelial cells (LECs) are the main reasons for vision loss caused by posterior capsular opacification (PCO) after cataract surgery. Insulin-like growth factor-1 (IGF-1) was found to be associated with the pathogenesis of cataracts, but its biological role in PCO is poorly understood. In the present study, IGF-1 overexpression facilitated the proliferation, migration, and EMT, whereas knockdown of IGF-1 markedly suppressed the proliferation, migration, and TGF-2-induced EMT of LECs. Additionally, to evaluate valuable microRNAs (miRNAs) which target IGF-1 to modulate LEC-EMT, we predicted miR-3666 might regulate IGF-1 by binding its 3'UTR according to the bioinformatics database. Furthermore, we verified that miR-3666 directly targeted IGF-1 by luciferase reporter assay. By using miR-3666 mimics, cell proliferation, migration, and invasion were suppressed, while being enhanced by the reduction of miR-3666. Knockout of IGF1 reverses the effect of the miR-3666 inhibitor on the malignant behavior of LECs. These results indicate the role of miR-3666/IGF-1 in LEC-EMT that offers new strategies for the therapy and prevention of PCO.
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http://dx.doi.org/10.1155/2022/5383146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303496PMC
August 2022

Rich Indium-Vacancies In S with Atomic p-n Homojunction for Boosting Photocatalytic Multifunctional Properties.

Small 2022 Jul 27:e2201556. Epub 2022 Jul 27.

State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun, 130012, P. R. China.

Design and development of highly efficient photocatalytic materials are key to employ photocatalytic technology as a sound solution to energy and environment related challenges. This work aims to significantly boost photocatalytic activity through rich indium vacancies (V ) In S with atomic p-n homojunction through a one-pot preparation strategy. Positron annihilation spectroscopy and electron paramagnetic resonance reveal existence of V in the prepared photocatalysts. Mott-Schottky plots and surface photovoltage spectra prove rich V In S can form atomic p-n homojunction. It is validated that p-n homojunction can effectively separate carriers combined with photoelectrochemical tests. V decreases carrier transport activation energy (CTAE) from 0.64 eV of V -poor In S to 0.44 eV of V -rich In S . The special structure endows defective In S with multifunctional photocatalysis properties, i.e., hydrogen production (872.7 µmol g h ), degradation of methyl orange (20 min, 97%), and reduction in heavy metal ions Cr(VI) (30 min, 98%) under simulated sunlight, which outperforms a variety of existing In S composite catalysts. Therefore, such a compositional strategy and mechanistic study are expected to offer new insights for designing highly efficient photocatalysts through defect engineering.
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http://dx.doi.org/10.1002/smll.202201556DOI Listing
July 2022

Systematic Study on the Luminescent Properties, Thermal Stability, and Magnetic Behavior of GdOF: RE (RE = Eu, Yb, and Er) Red Phosphors with Various Morphologies.

Inorg Chem 2022 Jul 7;61(28):10642-10651. Epub 2022 Jul 7.

College of Chemistry, Jilin University, Qianjin Street 2699, Changchun 130012, People's Republic of China.

In this work, GdOF:RE (RE = Eu, Yb, and Er) phosphors with high thermally stable luminescence were reported, which were synthesized by an ionic liquid-assisted two-phase system and subsequent calcination technique for the first time. Nanodisks, nanorod aggregates, nanoneedles, and stubby nanorods were obtained by simply regulating the pH value. The luminescent properties of precursors and products were discussed in detail. By carefully adjusting the calcination temperature and the pH value of the initial system, pure red emission was achieved in both GdOF:Eu and GdOF:Yb, Er phosphors. The reason for distinct luminescent properties of different products was discussed from various perspectives. Moreover, the temperature-dependent spectra were measured and the GdOF:Eu and GdOF:Yb, Er products both exhibited outstanding thermal stability. In addition, the as-prepared nanomaterials presented paramagnetic properties, indicating their potential application in both field-emission displays and magnetic resonance imaging technology.
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http://dx.doi.org/10.1021/acs.inorgchem.2c00299DOI Listing
July 2022

Ultrasound improved immune adjuvant delivery to induce DC maturation and T cell activation.

J Control Release 2022 Jul 4;349:18-31. Epub 2022 Jul 4.

Department of Ultrasound in Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, No. 88 Jiefang Road, Shangcheng District, Hangzhou 310009, PR China; Research Center of Ultrasound in Medicine and Biomedical Engineering, The Second Affiliated Hospital of Zhejiang University School of Medicine, No. 88 Jiefang Road, Shangcheng District, Hangzhou 310009, PR China. Electronic address:

Tumor immunotherapy has emerged as a promising approach to tumor treatment. Currently, immune adjuvant-based therapeutic modalities are rarely curative in solid tumors owing to challenges including the low permeability and extremely poor water solubility of these adjuvants, limiting their ability to effectively promote dendritic cell (DC) maturation. Herein, we employed ultrasound-mediated cavitation (UMC) to promote the delivery of Toll-like receptor agonist (R837)-loaded pH-responsive liposomes ([email protected]) to tumors. The tumor-associated antigens (TAAs) produced by UMC treatment exhibited vaccinal activity, particularly in the presence of immune adjuvants, together promoting the maturation of DC and inducing cytokine production. Importantly, UMC can down-regulate immune checkpoint molecules, like Cd274, Foxp3 and Ctla4, synergistically stimulating the activation and proliferation of T cells in the body to facilitate tumor treatment. This UMC-enhanced [email protected] approach was able to induce a robust antitumor immune response capable of arresting primary and distant tumor growth, while also developing immunological memory, protecting against tumor rechallenge following initial tumor clearance. Overall, these results highlight a promising UMC- and pH-sensitive immune adjuvant delivery-based treatment for tumors with the potential for clinical application.
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http://dx.doi.org/10.1016/j.jconrel.2022.06.054DOI Listing
July 2022

Visible-Light-Responsive UiO-66(Zr) with Defects Efficiently Promoting Photocatalytic CO Reduction.

ACS Appl Mater Interfaces 2022 Jun 17;14(25):28977-28984. Epub 2022 Jun 17.

State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. China.

It is of great importance to understand the relationship between the structure and properties at the atomic level, which provides a solid platform for the design of efficient heterogeneous catalysts. However, it remains a challenge to elucidate the roles of the structure of reaction sites in the catalytic activity of active sites due to the lack of understanding of the structure of specific active site species. Herein, taking the metal-organic framework (MOF) UiO-66(Zr) as a prototype, MOF catalysts with all-solid-state frustrated Lewis pairs (FLPs) Zr-OH were synthesized in situ by adding acetic acid (HAc) as a modulator. By introducing missing linkers, UiO-66(Zr) first becomes a visible-light-responsive photocatalyst for CO reduction. The in situ Fourier transform infrared (FTIR) spectrum reveals that b-CO is the key intermediate for the activation of CO molecules through FLPs Zr-OH. Moreover, defective UiO-66(Zr) could "self-breath" by surface hydroxyls. This finding not only provides a new avenue for utilizing UV-responsive MOFs by defect engineering but also sheds light on its catalytic activity at the atomic level.
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http://dx.doi.org/10.1021/acsami.2c06993DOI Listing
June 2022

Quantitative Evaluation of Carrier Dynamics in Full-Spectrum Responsive Metallic ZnInS with Indium Vacancies for Boosting Photocatalytic CO Reduction.

Nano Lett 2022 Jun 9;22(12):4970-4978. Epub 2022 Jun 9.

State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, People's Republic of China.

The influence of defects on quantitative carrier dynamics is still unclear. Therefore, full-spectrum responsive metallic ZnInS (V-rich-ZIS) rich in indium vacancies and exhibiting high CO photoreduction efficiency was synthesized for the first time. The influence of the defects on the carrier dynamic parameters was studied quantitatively; the results showed that the minority carrier diffusion length () is closely related to the catalytic performance. In situ infrared spectroscopy and theoretical calculations revealed that the presence of indium vacancies lowers the energy barrier for CO to CO conversion via the COOH* intermediate. Hence, the high rate of CO evolution reaches 298.0 μmol g h, a nearly 28-fold enhancement over that with ZnInS (V-poor-ZIS), which is not rich in indium vacancies. This work fills the gaps between the catalytic performance of defective photocatalysts and their carrier dynamics and may offer valuable insight for understanding the mechanism of photocatalysis and designing more efficient defective photocatalysts.
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http://dx.doi.org/10.1021/acs.nanolett.2c01666DOI Listing
June 2022

Three-pole wheel paddle luminescent metal organic frameworks (LMOFs) based on the oxygen substituted triazine tricarboxylic acid ligand: recognition and detection of small drug molecules and aromatic amine molecules.

Dalton Trans 2022 Jun 21;51(24):9336-9347. Epub 2022 Jun 21.

State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, P.R. China.

Luminescent metal organic frameworks (LMOFs) are considered to be a type of promising optical sensing material due to their designable and tunable functions, and stable pore structures. Therefore, the preparation of LMOFs has become a research hotspot in recent years. As we know, triazine carboxylic acid ligands are conducive for constructing LMOF materials due to their large π electron conjugated system. In this work, two crystalline materials [Cd(TCPT)]·0.5DMF·4HO (1) and (HO)[Zn(TCPT)(μ-OH)]·0.5DMF·3HO (2) were obtained by the reaction of the triazine carboxylic acid ligand 2,4,6-tris(4-carboxyphenoxy)-1,3,5-triazine (HTCPT), as an extended carboxylate arm, and d transition metal salts. Their structures were determined by single crystal X-ray diffraction and characterized by infrared spectroscopy (IR), ultraviolet visible spectroscopy (UV-vis), fluorescence spectroscopy, powder X-ray diffraction (PXRD) and thermogravimetric analysis (TG). The experimental results showed that complexes 1 and 2 show excellent fluorescent emission behavior. Thus, we explored their fluorescence sensing properties. To our delight, the results showed that they both had the ability to sense small organic drug molecules and aromatic amine molecules containing -phenylenediamine (OPD), -phenylenediamine (MPD) and -phenylenediamine (PPD). In general, the practical applications of a MOF material are usually limited because of the relatively harsh synthesis methods. In this aspect, we studied the synthesis method in detail to obtain the optimal reaction conditions for the large-scale synthesis of 1 and 2. The preparation of the two LMOF materials only required about 3 hours of heating time and they could be prepared on a large scale, which is significant for the practical applications of LMOFs.
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http://dx.doi.org/10.1039/d2dt01032aDOI Listing
June 2022

Mass Production of Pt Single-Atom-Decorated Bismuth Sulfide for n-Type Environmentally Friendly Thermoelectrics.

Nano Lett 2022 Jun 31;22(12):4750-4757. Epub 2022 May 31.

School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.

Single-atom materials are widely explored in catalysis, batteries, sensors, etc. However, limited by mass production and centimeter-scale assembly, they are rarely studied in thermoelectrics. Herein, we demonstrate a solvothermal synthesis assisted by a syringe-pump method to yield BiS-supported Pt single-atom materials (BiS-Pt) at a 10 g scale. Different from Pt clusters, Pt single atoms can increase carrier concentration at a high doping efficiency and provide a unique atomic environment to enhance carrier mobility, and an enlarged effective mass leads to an enhanced Seebeck coefficient. As a result, a high power factor (348 μW m K) is achieved at 823 K. Benefiting from the scattering of phonons by Pt atomic sites, a minimum thermal conductivity of 0.37 W m K is achieved. Consequently, the BiS-0.5 wt % Pt realizes a record-high of ∼0.75 at 823 K, being among the best in the state-of-the-art n-type environmentally friendly metal sulfides. The enhancement of the carrier mobility and suppression of the thermal conduction by the unique Pt single atoms will inspire various fields, as exemplified by electronic devices and thermal management.
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http://dx.doi.org/10.1021/acs.nanolett.2c00947DOI Listing
June 2022

Hypertension modifies the associations of body mass index and waist circumference with all-cause mortality among older Chinese: a retrospective cohort study.

BMC Geriatr 2022 05 19;22(1):441. Epub 2022 May 19.

College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.

Background: The effect of baseline hypertension status on the BMI-mortality association is still unclear. We aimed to explore the relationships of body mass index (BMI) and waist circumference (WC) with all-cause mortality among older hypertensive and normotensive Chinese individuals.

Methods: This retrospective cohort study was conducted in Xinzheng, Henan Province, Central China. The data came from the residents' electronic health records of the Xinzheng Hospital Information System. A total of 77,295 participants (41,357 hypertensive participants and 35,938 normotensive participants) aged ≥ 60 years were included from January 2011 to November 2019. Cox proportional hazard regression model was used to examine the relationships.

Results: During a mean follow-up of 5.3 years, 10,755 deaths were identified (6,377 in hypertensive participants and 4,378 in normotensive participants). In adjusted models, compared with a BMI of 18.5-24 kg/m, the hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) of BMI < 18.5, 24-28 and ≥ 28 kg/m for mortality in hypertensive participants were 1.074 (0.927-1.244), 0.881 (0.834-0.931) and 0.856 (0.790-0.929), respectively, and 1.444 (1.267-1.646), 0.884 (0.822-0.949) and 0.912 (0.792-1.051), respectively, in normotensive participants. Compared with normal waist circumference, the adjusted HRs and 95% CIs of central obesity for mortality were 0.880 (0.832-0.931) in hypertensive participants and 0.918 (0.846-0.996) in normotensive participants. A sensitivity analysis showed similar associations for both hypertensive and normotensive participants.

Conclusion: Low BMI and WC were associated with a higher risk of all-cause mortality regardless of hypertension status in older Chinese individuals. The lowest risk of death associated with BMI was in the overweight group in normotensive participants and in the obesity group in hypertensive participants.
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http://dx.doi.org/10.1186/s12877-022-03057-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118767PMC
May 2022

Retroperitoneal gastric hernia misdiagnosed as the adrenal tumor: A rare case report.

Asian J Surg 2022 08 12;45(8):1575-1576. Epub 2022 May 12.

Department of Urology, Taizhou First People's Hospital, Zhejiang Province, China. Electronic address:

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http://dx.doi.org/10.1016/j.asjsur.2022.04.108DOI Listing
August 2022

Enhancement of antitumor immunotherapy using mitochondria-targeted cancer cell membrane-biomimetic MOF-mediated sonodynamic therapy and checkpoint blockade immunotherapy.

J Nanobiotechnology 2022 May 14;20(1):228. Epub 2022 May 14.

Department of Ultrasound in Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang University, No. 88 Jiefang Road, Shangcheng District, Hangzhou, 310009, People's Republic of China.

Immunotherapeutic interventions represent a promising approach to treating cancer, with strategies such as immune checkpoint blockade (ICB), immunogenic sonodynamic therapy (SDT), and immune adjuvant T cell delivery having exhibited clinical promise. In this report, we describe the use of cancer cell membrane-coated triphenylphosphonium (TPP) decorated nano-metal-organic framework (nMOF) constructs [Zr-TCPP(TPP)/[email protected]] that were used to generate homologous, mitochondria-targeted platforms with a high rate of sonosensitizer loading. This construct was utilized to simultaneously promote tumor antigen presentation via enhancing SDT while synergistically promoting dendritic cell (DC) maturation through the delivery of the Toll-like receptor agonist R837. In vitro, these functionalized nMOFs were readily internalized by homologous tumor cells in which they were efficiently targeted to the mitochondria, promoting DC activation through the induction of immunogenic cell death (ICD) following ultrasound exposure. Moreover, this nanoplatform was able to achieve in vivo synergy with anti-CTLA-4 ICB to reverse immunosuppression tumor microenvironment (TME), thus achieving more robust antitumor efficacy capable of suppressing metastatic disease progression and facilitating the development of durable antitumor memory responses. Together, these results highlight a promising approach to achieving enhanced SDT activity while overcoming an immunosuppressive TME, thereby achieving more robust antitumor immunity.
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http://dx.doi.org/10.1186/s12951-022-01453-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107704PMC
May 2022

Modified ligation procedure for prolapsed haemorrhoids versus stapled haemorrhoidectomy for the management of symptomatic haemorrhoids (MoLish): randomized clinical trial.

BJS Open 2022 05;6(3)

Departments of Anorectal Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, P.R. China.

Background: The aim of this study was to compare a modified ligation procedure versus stapled haemorrhoidectomy (SH) in patients with symptomatic haemorrhoids.

Methods: This randomized trial included patients with symptomatic haemorrhoids treated in Shanghai from May 2018 to September 2021. Eligible patients were randomly 1:1 assigned the modified ligation procedure for prolapsed haemorrhoids (MLPPH) and SH groups. The primary outcome was the assessment of efficacy at 6 months after the intervention. The operating time, incidence of complications, clinical effectiveness (pain, Wexner incontinence, haemorrhoid symptom severity (HSS) scores, and 6-month cure rate) were collected, and quality-adjusted life years (QALYs) were adopted as indicator for the cost-effectiveness analysis (CEA).

Results: Out of 187 patients screened, 133 patients were randomized (67 for MLPPH and 66 for SH). One patient in the MLPPH group was excluded, and two patients were lost to follow-up. The mean operating time was longer in MLPPH than in SH (57.42 min versus 30.68 min; P < 0.001). The median pain score was higher in SH than in MLPPH at postoperative day 3 (P = 0.018), day 7(P = 0.013), and day 14 (P = 0.003). The median Wexner incontinence score was higher in SH than in MLPPH at postoperative month 1 (P = 0.036) and month 3 (P = 0.035), but was similar in the two groups at month 6. In addition, the median HSS score was lower in MLPPH than in SH 6 months after surgery (P = 0.003). The 6-month cure rate was higher in MLPPH than in SH (P = 0.003). CEA showed lower mean costs in MLPPH than in SH (EUR 1080.24 versus EUR 1657.97; P < 0.001) but there was no significant difference in effectiveness (P = 0.181). However, MLPPH was cost-effective (incremental cost-effectiveness ratio, -120 656.19 EUR/QALYs).

Conclusion: MLPPH was documented as a longer but cost-effective procedure, it provided lower short-term pain, and Wexner and HSS scores. Registration number: Chinese Clinical Trial Registry ChiCTR1800015928 (http://www.chictr.org.cn/searchproj.aspx).
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http://dx.doi.org/10.1093/bjsopen/zrac064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099087PMC
May 2022

The Effect of Qingre Huayu Recipe on Wound Healing after Anal Fistulotomy in Sprague-Dawley Rats.

Comput Math Methods Med 2022 19;2022:9397478. Epub 2022 Apr 19.

Department of Proctology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, No. 164 Lanxi Road, Shanghai 200333, China.

Anal fistula is a common anorectal disease. At present, most scholars believe that its pathogenesis is related to anal gland infection. Anal fistula cannot heal on its own after the onset and must be treated surgically. The wound of anal fistula surgery is open and polluted, and it belongs to three types of three-stage healing; it is the most difficult to heal among all surgical incisions, with a long course of disease, a lot of exudation, and pain for the patient; traditional Chinese medicine has rich experience in the treatment of postoperative wound healing of anal fistula. The study aimed to evaluate the mechanism of Qingre Huayu (QRHY) Recipe on wound healing after fistulotomy on SD rats. SD rats ( = 72) were randomized into three groups post-anorectal surgery. The rats in the positive control group were given potassium permanganate (PP), treatment group were given QRHY, and trauma model group were given 0.9% normal salinity. The changes in wound secretion, granulated tissue, and epithelium tissue were observed, and wound healing rates were evaluated by the discrepancies in wound area. HE and Masson's staining as well as transmission electron microscopy were also performed. The localization as well as the measurement of Ang1, Src, and VE cadherin expression in each group adopted real-time PCR, western blot, and immunohistochemistry (IHC) assays. Statistically higher wound healing rates were observed in QRHY group on days 3, 7, and 14 compared with other groups. Histological analyses showed highly significant increase in collagen and fibroblasts, less inflammatory cells, and vascular endothelial permeability in QRHY rats. The transmission electron microscopy revealed that the intact structure of tight junctions in endothelial cells and well-organized collagen and VE-cadherin, Ang1, and Tie-2 were upregulated by QRHY, while Src was inhibited. This study showed that QRHY can promote wound healing after anal fistulas.
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http://dx.doi.org/10.1155/2022/9397478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042638PMC
May 2022

Installation of synergistic binding sites onto porous organic polymers for efficient removal of perfluorooctanoic acid.

Nat Commun 2022 04 19;13(1):2132. Epub 2022 Apr 19.

Department of Chemistry, University of North Texas 1508W Mulberry St, Denton, TX, 76201, USA.

Herein, we report a strategy to construct highly efficient perfluorooctanoic acid (PFOA) adsorbents by installing synergistic electrostatic/hydrophobic sites onto porous organic polymers (POPs). The constructed model material of PAF-1-NDMB (NDMB = N,N-dimethyl-butylamine) demonstrates an exceptionally high PFOA uptake capacity over 2000 mg g, which is 14.8 times enhancement compared with its parent material of PAF-1. And it is 32.0 and 24.1 times higher than benchmark materials of DFB-CDP (β-cyclodextrin (β-CD)-based polymer network) and activated carbon under the same conditions. Furthermore, PAF-1-NDMB exhibits the highest k value of 24,000 g mg h among all reported PFOA sorbents. And it can remove 99.99% PFOA from 1000 ppb to <70 ppt within 2 min, which is lower than the advisory level of Environmental Protection Agency of United States. This work thus not only provides a generic approach for constructing PFOA adsorbents, but also develops POPs as a platform for PFOA capture.
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http://dx.doi.org/10.1038/s41467-022-29816-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019033PMC
April 2022

Coexistence of thrombotic thrombocytopenic purpura and immune thrombocytopenic purpura in an Asian woman: a case report.

J Int Med Res 2022 Mar;50(3):3000605221085127

Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54, Youdian Road, Hangzhou, China.

A 33-year-old Chinese woman with a history of immune thrombocytopenic purpura presented with heavy menstrual bleeding. She was found to have thrombocytopenia, plasma ADAMTS13 activity of 0%, and positivity for the plasma ADAMTS13 inhibitor. She was diagnosed with the coexistence of thrombotic thrombocytopenic purpura and immune thrombocytopenic purpura. The patient was treated by plasmapheresis, a glucocorticoid, and rituximab. Her platelet level returned to normal, and she was discharged 28 days after admission. The number of plasmapheresis sessions and the timing of rituximab administration may be the key aspects of management of patients with thrombotic thrombocytopenic purpura who have underlying immune dysfunction caused by diseases such as immune thrombocytopenic purpura.
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http://dx.doi.org/10.1177/03000605221085127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8973045PMC
March 2022

Regulatory functions of miR‑200b‑3p in tumor development (Review).

Oncol Rep 2022 05 24;47(5). Epub 2022 Mar 24.

General Surgery, Cancer Center, Department of Colorectal Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang 310014, P.R. China.

MicroRNAs (miRNAs/miRs), non‑coding single‑stranded RNAs of length 18‑24 nucleotides, can modulate gene expression through post‑transcriptional control. As such, they can influence tumor proliferation, apoptosis, invasion, metastasis as well as chemotherapy resistance by regulating certain downstream genes. In this context, miR‑200b‑3p, one particular member of the miR‑200 family, possesses the ability to suppress tumor progression. However, many studies have suggested that, in certain cases, this miRNA may also promote the development of some tumors due to differences in the microenvironments and molecular backgrounds of different cancers. This review summarizes previous studies on the involvement of miR‑200b‑3p in tumors, including the underlying mechanism.
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http://dx.doi.org/10.3892/or.2022.8307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968761PMC
May 2022

Poly(Anthraquinonyl Sulfide)/CNT Composites as High-Rate-Performance Cathodes for Nonaqueous Rechargeable Calcium-Ion Batteries.

Adv Sci (Weinh) 2022 May 20;9(14):e2200397. Epub 2022 Mar 20.

State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University, Changchun, 130012, P. R. China.

Calcium-ion batteries (CIBs) are considered as promising alternatives in large-scale energy storage due to their divalent electron redox properties, low cost, and high volumetric/gravimetric capacity. However, the high charge density of Ca contributes to strong electrostatic interaction between divalent Ca and hosting lattice, leading to sluggish kinetics and poor rate performance. Here, in situ formed poly(anthraquinonyl sulfide) (PAQS)@CNT composite is reported as nonaqueous calcium-ion battery cathode. The enolization redox chemistry of organics has fast redox kinetics, and the introduction of carbon nanotube (CNT) accelerates electron transportation, which contributes to fast ionic diffusion. As the conductivity of the PAQS is enhanced by the increasing content of CNT, the voltage gap is significantly reduced. The [email protected] electrode exhibits specific capacity (116 mAh g at 0.05 A g ), high rate capacity (60 mAh g at 4 A g ), and an initial capacity of 82 mAh g at 1 A g (83% capacity retention after 500 cycles). The electrochemical mechanism is proved to be that the PAQS undergoes reduction reaction of their carbonyl bond during discharge and becomes coordinated by Ca and Ca(TFSI) species. Computational simulation also suggests that the construction of Ca and Ca(TFSI) co-intercalation in the PAQS is the most reasonable pathway.
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http://dx.doi.org/10.1002/advs.202200397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108664PMC
May 2022

Use of Nab-Paclitaxel Plus Gemcitabine Followed by Hypofractionated Tomotherapy With Simultaneous Integrated Boost in Patients With Locally Advanced Pancreatic Cancer.

Front Oncol 2022 1;12:782730. Epub 2022 Mar 1.

The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University, Clinical Cancer Institute of Nanjing University, Nanjing, China.

Background And Purpose: A phase 2 study LAPACT indicated nab-paclitaxel plus gemcitabine (AG) improved outcomes of patients with locally advanced pancreatic cancer (LAPC). Conventional radiotherapy failed to show benefit, indicating high dose to volume with high risk of recurrence is needed. The high dose can be delivered through hypofractionated tomotherapy with simultaneous integrated boost (SIB). However, there is a lack of such prospective trials and more data are needed to validate the role of AG plus hypofractionated tomotherapy with SIB in patients with LAPC.

Materials And Methods: Patients with LAPC receiving AG plus tomotherapy at the Nanjing Drum Tower Hospital between 2018 and 2021 were retrospectively analyzed. The treatment was scheduled as follows: nab-paclitaxel 125 mg/m plus gemcitabine 1,000 mg/m on days 1 and 8 every three weeks for at least two cycles, followed by hypofractionated tomotherapy with SIB (high dose field: 50 Gy/10 fractions, the remainder: 30 Gy/10 fractions). Then patients were given AG until intolerance or disease progression.

Results: Overall, 22 patients completing the chemoradiotherapy were included. The median follow-up was 15.2 months. After the chemoradiotherapy, 5 patients achieved a partial response (PR), 15 had a stable disease (SD), and another 2 patients were with progressive disease (PD). The median progression-free survival (PFS) and overall survival (OS) were 12.8 months (95% confidence interval [CI] 4.3-21.3 months) and 16.3 months (95% CI 10.9-21.6 months), respectively. The optimal carbohydrate antigen (CA) 19-9 response and chemotherapy cycles ≥6 were correlated with favorable PFS and OS. The most common recurrent pattern was peritoneal dissemination (22.7%) and the locoregional recurrence rate was relatively low (4.5%). Treatments were well-tolerated. The most common grade ≥3 adverse event was thrombocytopenia (13.6%).

Conclusion: This study demonstrated the feasibility of AG followed by hypofractionated tomotherapy with SIB in patients with LAPC. The hypofractionated tomotherapy with SIB was safe and showed high local control rate. Further study with a larger population to validate our data is underway.
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http://dx.doi.org/10.3389/fonc.2022.782730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922029PMC
March 2022

A multicenter retrospective study of transurethral prostate split for benign prostate hyperplasia.

Transl Androl Urol 2022 Feb;11(2):213-227

Department of Urology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Background: Transurethral split of the prostate (TUSP) is effective in treating benign prostatic hyperplasia (BPH). However, there is still a lack of research focusing on the optimal target population for TUSP. This study aimed to compare the efficacy of TUSP in patients with different prostate volumes or ages.

Methods: The study was a multicenter retrospective study. The outcomes of TUSP in BPH patients with different prostate volumes or different ages were compared. A total of 439 patients were included in the study. Patients were divided into two groups according to prostate volume, with a cut-off value of 50 mL. Similarly, the cut-off value for the age groups was 70 years. Baseline patient characteristics and perioperative outcomes were recorded. Follow-up was performed at 1, 6, and 12 months after surgery.

Results: The mean age of the patients was 73.4 years, and the mean prostate volume was 51.2 mL. At 12-month follow-up after TUSP treatment, the patients' International Prostate Symptom Scores (IPSS), quality of life (QoL) scores, and postvoid residual (PVR) volumes decreased significantly, while peak urinary flow rate (Qmax) increased significantly. Intraoperative hemoglobin (Hb) reduction was significantly lower in the small volume group than in the large volume group. The incidence of postoperative urinary urgency and transient incontinence was lower in the small volume group. IPSS score, PVR, and Qmax in the small volume group showed more remarkable changes at several time points compared to the preoperative period. Postoperative pain scores were higher in the small volume group than in the large volume group. There were no differences between the two groups in terms of long-term complications. The younger group showed greater variation in PVR and Qmax at some time points but less variation in QoL than the older group.

Conclusions: TUSP is overall safe and effective in treating BPH. This study showed differences in the outcomes of TUSP in treating different prostate volumes or ages of BPH patients. The optimal surgical approach for BPH patients might be selected clinically based on a combination of prostate volume or patient age.
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http://dx.doi.org/10.21037/tau-21-1138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899149PMC
February 2022

Stronger Associations of Body Mass Index and Waist Circumference with Diabetes than Waist-Height Ratio and Triglyceride Glucose Index in the Middle-Aged and Elderly Population: A Retrospective Cohort Study.

J Diabetes Res 2022 26;2022:9982390. Epub 2022 Feb 26.

College of Nursing and Health, Zhengzhou University, Zhengzhou, Henan, China.

Background: It remains controversial whether body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR), or triglyceride glucose (TyG) index has a stronger association with diabetes. The aims of the study were to compare the magnitude of associations of four indicators with diabetes risk.

Methods: Data collected from annual health examination dataset in the Xinzheng during 2011 and 2019. A total of 41,242 participants aged ≥ 45 years were included in this study. Cox proportional hazard regression models were used to examine associations between the four indicators and diabetes risk.

Results: After 205,770 person-years of follow up, diabetes developed in 2,472 subjects. Multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of diabetes (highest vs reference group) were 1.92 (1.71-2.16) for BMI, 1.99 (1.78-2.23) for WC, 1.65 (1.47-1.86) for WHtR, and 1.66 (1.47-1.87) for TyG, respectively. In addition, the risk of diabetes increased with baseline BMI (HR: 1.30; 95% CI: 1.25, 1.35) and TyG (HR: 1.25; 95% CI: 1.20, 1.30), but the lowest HR was 0.78 (95% CI 0.65-0.92) when WC was approximately 72 cm, and 0.85 (95% CI 0.72-0.99) when WHtR was approximately 0.47 in women. In joint analyses, the highest risk was observed in participants with a high BMI combined with a high WC (HR: 2.26; 95% CI: 1.98, 2.58).

Conclusions: In middle-aged and elderly Chinese population, BMI and WC were more strongly associated with diabetes than WHtR or TyG, especially the combined effect of BMI and WC.
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http://dx.doi.org/10.1155/2022/9982390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898128PMC
March 2022

The recombinant human fibroblast growth factor-18 (sprifermin) improves tendon-to-bone healing by promoting chondrogenesis in a rat rotator cuff repair model.

J Shoulder Elbow Surg 2022 Aug 20;31(8):1617-1627. Epub 2022 Feb 20.

Department of Orthopedics, Jinshan District Central Hospital affiliated to Shanghai University of Medicine & Health Sciences, Shanghai, China; Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. Electronic address:

Background: Rotator cuff healing is improved by reconstructing the fibrocartilaginous structure of the tendon-to-bone enthesis. Fibroblast growth factor (FGF)-18 (sprifermin) is a well-known growth factor that improves articular cartilage repair via its anabolic effect. This study aimed to investigate the effect of recombinant human FGF-18 (rhFGF-18) on the chondrogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs) in vitro and tendon-to-bone healing in a rat model of rotator cuff repair.

Methods: Histological and reverse transcription-quantitative real-time polymerase chain reaction analyses of chondral pellets cultured with different concentrations of rhFGF-18 were performed. Bilateral detachment and repair of the supraspinatus tendon were performed on rats. The rats were administered 0.2 mL of sodium alginate (SA) hydrogel with (rhFGF-18/SA group, n = 12) or without (SA group, n = 12) 20 μg of rhFGF-18 into the repaired side. The simple repair group (n = 12) served as a control. At 4 and 8 weeks after surgery, histological analysis and biomechanical tests were performed.

Results: After chondrogenesis induction, compared with the control group, 10 ng/mL of rhFGF-18 increased pellet volume significantly (P = .002), with improved histological staining. It was noted that 10 ng/mL of rhFGF-18 upregulated the mRNA expression (relative ratio to control) of aggrecan (2.59 ± 0.29, P < .001), SRY-box transcription factor 9 (1.88 ± 0.05, P < .001), and type II collagen (1.46 ± 0.18, P = .009). At 4 and 8 weeks after surgery, more fibrocartilage and cartilaginous extracellular matrix was observed in rhFGF-18/SA-treated rats. The semiquantitative data from picrosirius red staining test were 31.1 ± 4.5 vs. 61.2 ± 4.1 at 4 weeks (P < .001) and 61.5 ± 2.8 vs. 80.5 ± 10.5 at 8 weeks (P = .002) (control vs. rhFGF-18/SA). Ultimate failure load (25.42 ± 3.61 N vs. 18.87 ± 2.71 N at 4 weeks and 28.63 ± 5.22 N vs. 22.15 ± 3.11 N at 8 weeks; P = .006 and P = .03, respectively) and stiffness (18.49 ± 1.38 N/mm vs. 14.48 ± 2.01 N/mm at 8 weeks, P = .01) were higher in the rhFGF-18/SA group than in the control group.

Conclusion: rhFGF-18 promoted chondrogenesis in the hBMSCs in vitro. rhFGF-18/SA improved tendon-to-bone healing in the rats by promoting regeneration of the fibrocartilage enthesis. rhFGF-18 (sprifermin) may be beneficial in improving tendon-to-bone healing after rotator cuff repair.
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http://dx.doi.org/10.1016/j.jse.2022.01.137DOI Listing
August 2022

Construction of Large-Scale Conjugated Functionalized Cyclotriphosphazene Lanthanide Framework for Selective Sensing of Volatile Organic Compounds and Assembly of Color-Tunable Dye-Encapsulated Composites.

Inorg Chem 2022 Feb 10;61(7):3111-3120. Epub 2022 Feb 10.

State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. China.

A flexible functionalized cyclotriphosphazene hexacarboxylic acid, hexakis(4-carboxylatephenoxy) cyclotriphosphazene (HCPCP), is used for the synthesis of a family of fluorescent Ln-HCPCP frameworks (Ln = La, Pr, Nd, Gd, and Ho). Structural analysis shows that the compounds exhibit 3D structures with [Ln(COO)], secondary building units formed by Ln-O-C-O-Ln connection. Then the molecules are connected to each other through HCPCP, forming rectangular channels along the -direction. Interestingly, the fluorescence sensing studies show that compound could be used as a multifunctional fluorescence sensor toward volatile organic compounds via different fluorescence emission behaviors. Moreover, a series of [email protected] composites (Dye = rhodamine B, safranine T, crystal violet, and malachite green) are successfully prepared with different quantum yields by the solvothermal reaction followed by cation exchanges.
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http://dx.doi.org/10.1021/acs.inorgchem.1c03405DOI Listing
February 2022

Glutathione-Bioimprinted Nanoparticles Targeting of N6-methyladenosine FTO Demethylase as a Strategy against Leukemic Stem Cells.

Small 2022 04 4;18(13):e2106558. Epub 2022 Feb 4.

State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, International Joint Research Laboratory of Nano-Micro Architecture Chemistry (NMAC), International Research Center for Chemistry-Medicine Joint Innovation, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, 130012, China.

The N6-methyladenosine (m A) demethylase FTO plays an oncogenic role in acute myeloid leukemia (AML). Despite the promising recent progress for developing some small-molecule FTO inhibitors, the clinical potential remains limited due to mild biological function, toxic side effects and low sensitivity and/or specificity to leukemic stem cells (LSCs). Herein, FTO inhibitor-loaded GSH-bioimprinted nanocomposites (GNPIPP12MA) are developed that achieves targeting of the FTO/m A pathway synergized GSH depletion for enhancing anti-leukemogenesis. GNPIPP12MA can selectively target leukemia blasts, especially LSCs, and induce ferroptosis by disrupting intracellular redox status. In addition, GNPIPP12MA increases global m A RNA modification and decreases the transcript levels in LSCs. GNPIPP12MA augments the efficacy of the PD-L1 blockade by increasing the infiltration of cytotoxic T cells for enhanced anti-leukemia immunity. This study offers insights for a GSH-bioimprinted nanoplatform targeting m A RNA methylation as a synergistic treatment strategy against cancer stem cells that may translate to clinical applications.
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http://dx.doi.org/10.1002/smll.202106558DOI Listing
April 2022

Neural-Network-Based Finite-Time Bipartite Containment Control for Fractional-Order Multi-Agent Systems.

IEEE Trans Neural Netw Learn Syst 2022 Jan 31;PP. Epub 2022 Jan 31.

This article focuses on the adaptive bipartite containment control problem for the nonaffine fractional-order multi-agent systems (FOMASs) with disturbances and completely unknown high-order dynamics. Different from the existing finite-time theory of fractional-order system, a lemma is developed that can be applied to actualize the aim of finite-time bipartite containment for the considered FOMASs, in which the settling time and convergence accuracy can be estimated. Via applying the mean-value theorem, the difficulty of the controller design generated by the nonaffine nonlinear term is overcome. A neural network (NN) is employed to approximate the ideal input signal instead of the unknown nonaffine function, then a distributed adaptive NN bipartite containment control for the FOMASs is developed under the backstepping structure. It can be proved that the bipartite containment error under the proposed control scheme can achieve finite-time convergence even though the follower agents are subjected to completely unknown dynamic and disturbances. Finally, the feasibility and validity of the obtained results are exhibited by the simulation examples.
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http://dx.doi.org/10.1109/TNNLS.2022.3143494DOI Listing
January 2022

Hormone Replacement Therapy Reverses Gut Microbiome and Serum Metabolome Alterations in Premature Ovarian Insufficiency.

Front Endocrinol (Lausanne) 2021 23;12:794496. Epub 2021 Dec 23.

Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Objective: We explored the gut microbiome and serum metabolome alterations in patients with premature ovarian insufficiency (POI) and the effects of hormone replacement therapy (HRT) with the aim to unravel the pathological mechanism underlying POI.

Methods: Fecal and serum samples obtained from healthy females (HC, n = 10) and patients with POI treated with (n = 10) or without (n = 10) HRT were analyzed using 16S rRNA gene sequencing and untargeted metabolomics analysis, respectively. Peripheral blood samples were collected to detect serum hormone and cytokine levels. Spearman's rank correlation was used to evaluate correlations between sex hormones and cytokines and between the gut microbiota and serum metabolites. To further confirm the correlation between and ovarian fibrosis, the mice were inoculated with () through oral gavage.

Results: The abundance of genus significantly increased in the fecal samples of patients with POI compared to that observed in the samples of HCs. This increase was reversed in patients with POI treated with HRT. Patients with POI showed significantly altered serum metabolic signatures and increased serum TGF-β1 levels; this increase was reversed by HRT. The abundance of was positively correlated with altered metabolic signatures, which were, in turn, positively correlated with serum TGF-β1 levels in all subjects. Estrogen ameliorated ovarian fibrosis induced by in mice.

Conclusions: The interactions between the gut microbiota, serum metabolites, and serum TGF-β1 in patients with POI may play a critical role in the development of POI. HRT not only closely mimicked normal ovarian hormone production in patients with POI but also attenuated gut microbiota dysbiosis and imbalance in the levels of serum metabolites and TGF-β1, which are reportedly associated with fibrosis. The findings of this study may pave the way for the development of preventive and curative therapies for patients with POI.
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http://dx.doi.org/10.3389/fendo.2021.794496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733385PMC
February 2022

High-Performance Aqueous Zinc-Ion Battery Based on an Al Mn O Cathode: A Design Strategy from Defect Engineering and Atomic Composition Tuning.

Small 2022 Feb 9;18(7):e2105970. Epub 2021 Dec 9.

State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin University, Changchun, 130012, P. R. China.

Rechargeable zinc-ion batteries (ZIBs), which adopt mild aqueous electrolytes with high power density and safety, have received significant interest. As the most widely used cathode material for ZIBs, manganese-based oxide has poor rate performance owing to its low electronic conductivity and slow ion diffusion kinetics. In this study, using the synergistic regulation strategy of defect engineering and atomic composition tuning, a mesoporous Al Mn O with an ultrahigh surface area (up to 82 m g ) is fabricated through Al substitution in the Mn O , followed by an Al-selective leaching process. During the entire process, numerous defects are obtained in the spinel structure by removing ≈30% of the Al cations. Al substitution can improve the material conductivity, while cation defects can weaken the electrostatic effect and promote ion diffusion ability. Therefore, the Al Mn O cathode of ZIBs exhibits a high reversible capacity of 302 mAh g at a current density of 100 mA g . Furthermore, the reversible capacity remains at 147 mAh g after 1000 cycles at a current density of 1500 mA g . This synergistic regulation of atomic composition tuning and defect engineering provides a new perspective for improving the performance of electrode materials in ZIBs.
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http://dx.doi.org/10.1002/smll.202105970DOI Listing
February 2022

An artificial intelligence platform to optimize workflow during ovarian stimulation and IVF: process improvement and outcome-based predictions.

Reprod Biomed Online 2022 02 20;44(2):254-260. Epub 2021 Oct 20.

Department of Statistics, University of Washington, Seattle WA, USA.

Research Question: Can workflow during IVF be facilitated by artificial intelligence to limit monitoring during ovarian stimulation to a single day and enable level-loading of retrievals?

Design: The dataset consisted of 1591 autologous cycles in unique patients with complete data including age, FSH, oestradiol and anti-Müllerian concentrations, follicle counts and body mass index. Observations during ovarian stimulation included oestradiol concentrations and follicle diameters. An algorithm was designed to identify the single best day for monitoring and predict trigger day options and total number of oocytes retrieved.

Results: The mean error to predict the single best day for monitoring was 1.355 days. After identifying the single best day for evaluation, the algorithm identified the trigger date and range of three oocyte retrieval days specified by the earliest and the latest day on which the number of oocytes retrieved was minimally changed with a variance of 0-3 oocytes. Accuracy for prediction of total number of oocytes with baseline testing alone or in combination with data on the day of observation was 0.76 and 0.80, respectively. The sensitivities for estimating the total number and number of mature oocytes based solely on pre-IVF profiles in group I (0-10) were 0.76 and 0.78, and in group II (>10) 0.76 and 0.81, respectively.

Conclusions: A first-iteration algorithm is described designed to improve workflow, minimize visits and level-load embryology work. This algorithm enables decisions at three interrelated nodal points for IVF workflow management to include monitoring on the single best day, assign trigger days to enable a range of 3 days for level-loading and estimate oocyte number.
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http://dx.doi.org/10.1016/j.rbmo.2021.10.006DOI Listing
February 2022
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