Publications by authors named "Zhan Deng"

18Publications

A Novel Evidence Conflict Measurement for Multi-Sensor Data Fusion Based on the Evidence Distance and Evidence Angle.

Sensors (Basel) 2020 Jan 9;20(2). Epub 2020 Jan 9.

School of Automation, Nanjing University of Science and Technology, Nanjing 210094, China.

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January 2020

Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor.

J Med Chem 2016 09 12;59(17):7773-82. Epub 2016 Jul 12.

Global Discovery Chemistry, ‡Oncology Disease Area, §Center for Proteomic Chemistry, ∥Metabolism and Pharmacokinetics, Novartis Institutes for Biomedical Research, and ⊥Chemical and Pharmaceutical Profiling, Novartis Pharmaceuticals , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.

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September 2016

Rethinking molecular similarity: comparing compounds on the basis of biological activity.

ACS Chem Biol 2012 Aug 31;7(8):1399-409. Epub 2012 May 31.

Center for Proteomic Chemistry, Novartis Institutes for Biomedical Research Inc., 250 Massachusetts Avenue, Cambridge, MA 02139, USA.

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August 2012

A lead discovery strategy driven by a comprehensive analysis of proteases in the peptide substrate space.

Protein Sci 2010 Nov;19(11):2096-109

Lead Discovery Informatics, Lead Finding Platform, Novartis Institutes for BioMedical Research, Inc., 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

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November 2010

Flexible 3D pharmacophores as descriptors of dynamic biological space.

J Mol Graph Model 2007 Oct 1;26(3):622-33. Epub 2007 Mar 1.

Lead Discovery Informatics, Lead Discovery Center, Novartis Institutes for BioMedical Research Inc., 250 Massachusetts Ave., Cambridge, MA 02139, United States.

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October 2007

Bridging chemical and biological space: "target fishing" using 2D and 3D molecular descriptors.

J Med Chem 2006 Nov;49(23):6802-10

Lead Discovery Informatics, Lead Discovery Center, Novartis Institutes for BioMedical Research Inc., 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

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November 2006

"Bayes affinity fingerprints" improve retrieval rates in virtual screening and define orthogonal bioactivity space: when are multitarget drugs a feasible concept?

J Chem Inf Model 2006 Nov-Dec;46(6):2445-56

Lead Discovery Informatics, Lead Discovery Center, Novartis Institutes for BioMedical Research Inc., 250 Massachusetts Ave., Cambridge, Massachusetts 02139, USA.

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February 2007

Structural interaction fingerprints: a new approach to organizing, mining, analyzing, and designing protein-small molecule complexes.

Chem Biol Drug Des 2006 Jan;67(1):5-12

Computational Drug Design Group, Department of Research Informatics, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, USA.

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January 2006

Knowledge-based design of target-focused libraries using protein-ligand interaction constraints.

J Med Chem 2006 Jan;49(2):490-500

Computational Drug Design Group, Biogen Idec, Inc., Cambridge, Massachusetts 02142, USA.

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January 2006

Interaction profiles of protein kinase-inhibitor complexes and their application to virtual screening.

J Med Chem 2005 Jan;48(1):121-33

Computational Drug Design Group, Department of Research Informatics, Biogen Idec, Inc., 14 Cambridge Center, Cambridge, Massachusetts 01242, USA.

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January 2005

Structural interaction fingerprint (SIFt): a novel method for analyzing three-dimensional protein-ligand binding interactions.

J Med Chem 2004 Jan;47(2):337-44

Department of Structural Informatics, Biogen, Inc., 12 Cambridge Center, Cambridge, Massachusetts 02142, USA.

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January 2004