Publications by authors named "Zhan Deng"

18Publications

Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer.

Authors:
Matthew J LaMarche Michael Acker Andreea Argintaru Daniel Bauer Julie Boisclair Homan Chan Christine Hiu-Tung Chen Ying-Nan Chen Zhouliang Chen Zhan Deng Michael Dore David Dunstan Jianmei Fan Peter Fekkes Brant Firestone Michelle Fodor Jorge Garcia-Fortanet Pascal D Fortin Cary Fridrich John Giraldes Meir Glick Denise Grunenfelder Huia-Xiang Hao Martin Hentemann Samuel Ho Andriana Jouk Zhao B Kang Rajesh Karki Mitsunori Kato Nick Keen Robert Koenig Laura R LaBonte Jay Larrow Gang Liu Shumei Liu Dyuti Majumdar Simon Mathieu Matthew J Meyer Morvarid Mohseni Rukundo Ntaganda Mark Palermo Lawrence Perez Minying Pu Timothy Ramsey John Reilly Patrick Sarver William R Sellers Martin Sendzik Michael D Shultz Joanna Slisz Kelly Slocum Troy Smith Stanley Spence Travis Stams Christopher Straub Victoriano Tamez Bakary-Barry Toure Christopher Towler Ping Wang Hongyun Wang Sarah L Williams Fan Yang Bing Yu Ji-Hu Zhang Suzanne Zhu

J Med Chem 2020 11 24;63(22):13578-13594. Epub 2020 Sep 24.

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November 2020

Systematic Chemogenetic Library Assembly.

Authors:
Stephen M Canham Yuan Wang Allen Cornett Douglas S Auld Daniel K Baeschlin Maude Patoor Philip R Skaanderup Ayako Honda Luis Llamas Greg Wendel Felipa A Mapa Peter Aspesi Nancy Labbé-Giguère Gabriel G Gamber Daniel S Palacios Ansgar Schuffenhauer Zhan Deng Florian Nigsch Mathias Frederiksen Simon M Bushell Deborah Rothman Rishi K Jain Horst Hemmerle Karin Briner Jeffery A Porter John A Tallarico Jeremy L Jenkins

Cell Chem Biol 2020 Sep 23;27(9):1124-1129. Epub 2020 Jul 23.

Novartis Institute for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address:

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September 2020

A Novel Evidence Conflict Measurement for Multi-Sensor Data Fusion Based on the Evidence Distance and Evidence Angle.

Authors:
Zhan Deng Jianyu Wang

Sensors (Basel) 2020 Jan 9;20(2). Epub 2020 Jan 9.

School of Automation, Nanjing University of Science and Technology, Nanjing 210094, China.

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January 2020

Discovery and Characterization of Allosteric WNK Kinase Inhibitors.

Authors:
Ken Yamada Ji-Hu Zhang Xiaoling Xie Juergen Reinhardt Amy Qiongshu Xie Daniel LaSala Darcy Kohls David Yowe Debra Burdick Hajime Yoshisue Hiromichi Wakai Isabel Schmidt Jason Gunawan Kayo Yasoshima Q Kimberley Yue Mitsunori Kato Muneto Mogi Neeraja Idamakanti Natasha Kreder Peter Drueckes Pramod Pandey Toshio Kawanami Waanjeng Huang Yukiko I Yagi Zhan Deng Hyi-Man Park

ACS Chem Biol 2016 12 19;11(12):3338-3346. Epub 2016 Oct 19.

Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.

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December 2016

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases.

Authors:
Ying-Nan P Chen Matthew J LaMarche Ho Man Chan Peter Fekkes Jorge Garcia-Fortanet Michael G Acker Brandon Antonakos Christine Hiu-Tung Chen Zhouliang Chen Vesselina G Cooke Jason R Dobson Zhan Deng Feng Fei Brant Firestone Michelle Fodor Cary Fridrich Hui Gao Denise Grunenfelder Huai-Xiang Hao Jaison Jacob Samuel Ho Kathy Hsiao Zhao B Kang Rajesh Karki Mitsunori Kato Jay Larrow Laura R La Bonte Francois Lenoir Gang Liu Shumei Liu Dyuti Majumdar Matthew J Meyer Mark Palermo Lawrence Perez Minying Pu Edmund Price Christopher Quinn Subarna Shakya Michael D Shultz Joanna Slisz Kavitha Venkatesan Ping Wang Markus Warmuth Sarah Williams Guizhi Yang Jing Yuan Ji-Hu Zhang Ping Zhu Timothy Ramsey Nicholas J Keen William R Sellers Travis Stams Pascal D Fortin

Nature 2016 07 29;535(7610):148-52. Epub 2016 Jun 29.

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July 2016

Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor.

Authors:
Jorge Garcia Fortanet Christine Hiu-Tung Chen Ying-Nan P Chen Zhouliang Chen Zhan Deng Brant Firestone Peter Fekkes Michelle Fodor Pascal D Fortin Cary Fridrich Denise Grunenfelder Samuel Ho Zhao B Kang Rajesh Karki Mitsunori Kato Nick Keen Laura R LaBonte Jay Larrow Francois Lenoir Gang Liu Shumei Liu Franco Lombardo Dyuti Majumdar Matthew J Meyer Mark Palermo Lawrence Perez Minying Pu Timothy Ramsey William R Sellers Michael D Shultz Travis Stams Christopher Towler Ping Wang Sarah L Williams Ji-Hu Zhang Matthew J LaMarche

J Med Chem 2016 09 12;59(17):7773-82. Epub 2016 Jul 12.

Global Discovery Chemistry, ‡Oncology Disease Area, §Center for Proteomic Chemistry, ∥Metabolism and Pharmacokinetics, Novartis Institutes for Biomedical Research, and ⊥Chemical and Pharmaceutical Profiling, Novartis Pharmaceuticals , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.

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September 2016

Rethinking molecular similarity: comparing compounds on the basis of biological activity.

Authors:
Paula M Petrone Benjamin Simms Florian Nigsch Eugen Lounkine Peter Kutchukian Allen Cornett Zhan Deng John W Davies Jeremy L Jenkins Meir Glick

ACS Chem Biol 2012 Aug 31;7(8):1399-409. Epub 2012 May 31.

Center for Proteomic Chemistry, Novartis Institutes for Biomedical Research Inc., 250 Massachusetts Avenue, Cambridge, MA 02139, USA.

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August 2012

A lead discovery strategy driven by a comprehensive analysis of proteases in the peptide substrate space.

Authors:
Sai Chetan K Sukuru Florian Nigsch Jean Quancard Martin Renatus Rajiv Chopra Natasja Brooijmans Dmitri Mikhailov Zhan Deng Allen Cornett Jeremy L Jenkins Ulrich Hommel John W Davies Meir Glick

Protein Sci 2010 Nov;19(11):2096-109

Lead Discovery Informatics, Lead Finding Platform, Novartis Institutes for BioMedical Research, Inc., 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

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November 2010

Which aspects of HTS are empirically correlated with downstream success?

Authors:
Andreas Bender Dejan Bojanic John W Davies Thomas J Crisman Dmitri Mikhailov Josef Scheiber Jeremy L Jenkins Zhan Deng W Adam G Hill Maxim Popov Edgar Jacoby Meir Glick

Curr Opin Drug Discov Devel 2008 May;11(3):327-37

Lead Finding Platform, Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.

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May 2008

"Plate cherry picking": a novel semi-sequential screening paradigm for cheaper, faster, information-rich compound selection.

Authors:
Thomas J Crisman Jeremy L Jenkins Christian N Parker W Adam G Hill Andreas Bender Zhan Deng James H Nettles John W Davies Meir Glick

J Biomol Screen 2007 Apr;12(3):320-7

Lead Discovery Center, Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.

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April 2007

Flexible 3D pharmacophores as descriptors of dynamic biological space.

Authors:
James H Nettles Jeremy L Jenkins Chris Williams Alex M Clark Andreas Bender Zhan Deng John W Davies Meir Glick

J Mol Graph Model 2007 Oct 1;26(3):622-33. Epub 2007 Mar 1.

Lead Discovery Informatics, Lead Discovery Center, Novartis Institutes for BioMedical Research Inc., 250 Massachusetts Ave., Cambridge, MA 02139, United States.

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October 2007

Bridging chemical and biological space: "target fishing" using 2D and 3D molecular descriptors.

Authors:
James H Nettles Jeremy L Jenkins Andreas Bender Zhan Deng John W Davies Meir Glick

J Med Chem 2006 Nov;49(23):6802-10

Lead Discovery Informatics, Lead Discovery Center, Novartis Institutes for BioMedical Research Inc., 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

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November 2006

"Bayes affinity fingerprints" improve retrieval rates in virtual screening and define orthogonal bioactivity space: when are multitarget drugs a feasible concept?

Authors:
Andreas Bender Jeremy L Jenkins Meir Glick Zhan Deng James H Nettles John W Davies

J Chem Inf Model 2006 Nov-Dec;46(6):2445-56

Lead Discovery Informatics, Lead Discovery Center, Novartis Institutes for BioMedical Research Inc., 250 Massachusetts Ave., Cambridge, Massachusetts 02139, USA.

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February 2007

A kinase-focused compound collection: compilation and screening strategy.

Authors:
Dongyu Sun Claudio Chuaqui Zhan Deng Scott Bowes Donovan Chin Juswinder Singh Patrick Cullen Gretchen Hankins Wen-Cherng Lee Jason Donnelly Jessica Friedman Serene Josiah

Chem Biol Drug Des 2006 Jun;67(6):385-94

Biogen Idec, 14 Cambridge Center, Cambridge, MA 02142, USA.

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June 2006

Structural interaction fingerprints: a new approach to organizing, mining, analyzing, and designing protein-small molecule complexes.

Authors:
Juswinder Singh Zhan Deng Gaurav Narale Claudio Chuaqui

Chem Biol Drug Des 2006 Jan;67(1):5-12

Computational Drug Design Group, Department of Research Informatics, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, USA.

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January 2006

Knowledge-based design of target-focused libraries using protein-ligand interaction constraints.

Authors:
Zhan Deng Claudio Chuaqui Juswinder Singh

J Med Chem 2006 Jan;49(2):490-500

Computational Drug Design Group, Biogen Idec, Inc., Cambridge, Massachusetts 02142, USA.

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January 2006

Interaction profiles of protein kinase-inhibitor complexes and their application to virtual screening.

Authors:
Claudio Chuaqui Zhan Deng Juswinder Singh

J Med Chem 2005 Jan;48(1):121-33

Computational Drug Design Group, Department of Research Informatics, Biogen Idec, Inc., 14 Cambridge Center, Cambridge, Massachusetts 01242, USA.

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January 2005

Structural interaction fingerprint (SIFt): a novel method for analyzing three-dimensional protein-ligand binding interactions.

Authors:
Zhan Deng Claudio Chuaqui Juswinder Singh

J Med Chem 2004 Jan;47(2):337-44

Department of Structural Informatics, Biogen, Inc., 12 Cambridge Center, Cambridge, Massachusetts 02142, USA.

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January 2004