Publications by authors named "Zepu Wang"

3 Publications

  • Page 1 of 1

Rare primary hepatic carcinosarcoma composed of hepatocellular carcinoma, cholangiocarcinoma, and sarcoma: a case report.

J Int Med Res 2021 Oct;49(10):3000605211050539

Department of Hepatobiliary, Pancreatic, and Splenic Surgery, 117872Hebei General Hospital, Hebei General Hospital, Shijiazhuang, China.

Primary hepatic carcinosarcoma (HCS) is an extremely rare malignant tumor of the liver that contains carcinomatous and sarcomatous components. The diagnosis, treatment, and prognosis of HCS pose great challenges to clinicians. Herein, we present a case of HCS in a 67-year-old man with unique pathological manifestation. Preoperative magnetic resonance imaging showed a malignant lesion in the right liver and a small sub-focus in the left liver. Radical treatment was performed, including excision of the right posterior lobe of the liver, thrombectomy of the right posterior portal vein, and radiofrequency ablation of lesions in the left liver. The specimens were confirmed to be HCS by pathological examinations, which revealed a combination of poorly differentiated hepatocellular carcinoma, moderately differentiated cholangiocellular carcinoma, and spindle cell sarcoma. Transhepatic arterial chemotherapy and embolization was performed after surgery. Unfortunately, pulmonary metastasis occurred 1.5 months later, which meant a poor prognosis. In this report, we discuss the clinicopathological characteristics of this case and factors that affected surgical outcomes, which may add some ideas for the future diagnosis and treatment of HCS patients.
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October 2021

Plasma Levels of Homocysteine is Associated with Liver Fibrosis in Health Check-Up Population.

Int J Gen Med 2021 3;14:5175-5181. Epub 2021 Sep 3.

Physical Examination Center, Hebei General Hospital, Shijiazhuang City, Hebei Province, People's Republic of China.

Object: Studies have shown a link between homocysteine (Hcy) and heart diseases, kidney diseases, cerebrovascular diseases, liver diseases, and other pathological conditions. However, the relationship between Hcy and liver fibrosis (LF) is unclear. Here, we studied the link between plasma Hcy concentration and LF.

Methods: We determined and recorded the plasma Hcy concentration, general biochemical parameters, and liver stiffness measurement (LSM) in 1582 subjects, followed by statistical data analyses.

Results: During different stages of LF, we found a considerable difference ( <0.001 unless specified) in body mass index (BMI), sex, age, Hcy, the levels of alanine transaminase (ALT), gamma-glutamyl transpeptidase (GGT; = 0.012), triglycerides (TG; = 0.006), low-density lipoprotein cholesterol (LDL-C), fasting blood glucose (FBS), and platelet count (PLT). There was a strong association between the plasma Hcy concentration and the serum biomarkers of LF ( <0.001) and the values of LSM ( <0.001).

Conclusion: The plasma Hcy concentration was substantially different among different stages of LF. The higher the plasma Hcy concentration, the more evident was the degree of LF.
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September 2021

Graphene oxide filled nanocomposite with novel electrical and dielectric properties.

Adv Mater 2012 Jun 9;24(23):3134-7. Epub 2012 May 9.

Department of Material Science and Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.

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June 2012