Publications by authors named "Zeng-Jie Wu"

12 Publications

  • Page 1 of 1

A CT-based radiomics signature for preoperative discrimination between high and low expression of programmed death ligand 1 in head and neck squamous cell carcinoma.

Eur J Radiol 2022 Jan 4;146:110093. Epub 2021 Dec 4.

Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:

Purpose: Accurate prediction of the expression level of programmed death ligand 1 (PD-L1) in head and neck squamous cell carcinoma (HNSCC) is crucial before immunotherapy. The purpose of this study was to construct and validate a contrast-enhanced computed tomography (CECT)-based radiomics signature to discriminate between high and low expression status of PD-L1.

Methods: A total of 179 HNSCC patients who underwent immunohistochemical examination of tumor PD-L1 expression at one of two centers were enrolled in this study and divided into a training set (n = 122; 55 high PD-L1 expression and 67 low PD-L1 expression) and an external validation set (n = 57; 26 high PD-L1 expression and 31 low PD-L1 expression). The least absolute shrinkage and selection operator method was used to select the key features for a CECT-image-based radiomics signature. The performance of the radiomics signature was assessed using receiver operating characteristics analysis.

Results: Six features were finally selected to construct the radiomics signature. The performance of the radiomics signature in the discrimination between high and low PD-L1 expression status was good in both the training and validation sets, with areas under the receiver operating characteristics curve of 0.889 and 0.834 for the training and validation sets, respectively.

Conclusions: The constructed CECT-based radiomics signature model showed favorable performance for discriminating between high and low PD-L1 expression status in HNSCC patients. It may be useful for screening out those patients with HNSCC who can best benefit from anti-PD-L1 immunotherapy.
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http://dx.doi.org/10.1016/j.ejrad.2021.110093DOI Listing
January 2022

A CT-based radiomics nomogram for differentiation of squamous cell carcinoma and non-Hodgkin's lymphoma of the palatine tonsil.

Eur Radiol 2022 Jan 8;32(1):243-253. Epub 2021 Jul 8.

Department of Radiology, The Affiliated Hospital of Qingdao University, NO. 16, Jiangsu Road, Qingdao, 266000, China.

Objectives: Accurate preoperative differentiation between squamous cell carcinoma (SCC) and non-Hodgkin's lymphoma (NHL) in the palatine tonsil is crucial because of their different treatment. This study aimed to construct and validate a contrast-enhanced CT (CECT)-based radiomics nomogram for preoperative differentiation of SCC and NHL in the palatine tonsil.

Methods: This study enrolled 135 patients with a pathological diagnosis of SCC or NHL from two clinical centers, who were divided into training (n = 94; SCC = 50, NHL = 44) and external validation sets (n = 41; SCC = 22, NHL = 19). A radiomics signature was constructed from radiomics features extracted from routine CECT images and a radiomics score (Rad-score) was calculated. A clinical model was established using demographic features and CT findings. The independent clinical factors and Rad-score were combined to construct a radiomics nomogram. Performance of the clinical model, radiomics signature, and nomogram was assessed using receiver operating characteristics analysis and decision curve analysis.

Results: Eleven features were finally selected to construct the radiomics signature. The radiomics nomogram incorporating gender, mean CECT value, and radiomics signature showed better predictive value for differentiating SCC from NHL than the clinical model for training (AUC, 0.919 vs. 0.801, p = 0.004) and validation (AUC, 0.876 vs. 0.703, p = 0.029) sets. Decision curve analysis demonstrated that the radiomics nomogram was more clinically useful than the clinical model.

Conclusions: A CECT-based radiomics nomogram was constructed incorporating gender, mean CECT value, and radiomics signature. This nomogram showed favorable predictive efficacy for differentiating SCC from NHL in the palatine tonsil, and might be useful for clinical decision-making.

Key Points: • Differential diagnosis between SCC and NHL in the palatine tonsil is difficult by conventional imaging modalities. • A radiomics nomogram integrated with the radiomics signature, gender, and mean contrast-enhanced CT value facilitates differentiation of SCC from NHL with improved diagnostic efficacy.
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http://dx.doi.org/10.1007/s00330-021-08153-9DOI Listing
January 2022

Development and validation of an MRI-based radiomics nomogram for distinguishing Warthin's tumour from pleomorphic adenomas of the parotid gland.

Dentomaxillofac Radiol 2021 Oct 5;50(7):20210023. Epub 2021 May 5.

Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China.

Objective:: Preoperative differentiation between parotid Warthin's tumor (WT) and pleomorphic adenoma (PMA) is crucial for treatment decisions. The purpose of this study was to establish and validate an MRI-based radiomics nomogram for preoperative differentiation between WT and PMA.

Methods And Materials: A total of 127 patients with histological diagnosis of WT or PMA from two clinical centres were enrolled in training set ( = 75; WT = 34, PMA = 41) and external test set ( = 52; WT = 24, PMA = 28). Radiomics features were extracted from axial T1WI and fs-T2WI images. A radiomics signature was constructed, and a radiomics score (Rad-score) was calculated. A clinical factors model was built using demographics and MRI findings. A radiomics nomogram combining the independent clinical factors and Rad-score was constructed. The receiver operating characteristic analysis was used to assess the performance levels of the nomogram, radiomics signature and clinical model.

Results: The radiomics nomogram incorporating the age and radiomics signature showed favourable predictive value for differentiating parotid WT from PMA, with AUCs of 0.953 and 0.918 for the training set and test set, respectively.

Conclusions: The MRI-based radiomics nomogram had good performance in distinguishing parotid WT from PMA, which could optimize clinical decision-making.
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http://dx.doi.org/10.1259/dmfr.20210023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474129PMC
October 2021

Computed tomography, magnetic resonance imaging, and F-deoxyglucose positron emission computed tomography/computed tomography findings of alveolar soft part sarcoma with calcification in the thigh: A case report.

World J Clin Cases 2020 Aug;8(15):3349-3354

Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, China.

Background: Alveolar soft part sarcoma (ASPS) is an extremely rare malignant sarcoma, accounting for less than 1% of all soft-tissue sarcomas. However, limited information is available on multimodal imaging [computed tomography (CT), magnetic resonance imaging (MRI), and positron emission computed tomography/computed tomography (PET/CT)] of ASPS.

Case Summary: This study reports a case of a 35-year-old female patient with ASPS of the left thigh with lung metastasis. The patient presented with a 1-year history of a palpable mass in the lower extremity, which exhibited rapid growth for 3 wk. CT, MRI, and F-deoxyglucose PET/CT examinations were performed. CT showed a slightly hypodense or isodense mass with patchy calcifications. On MRI examination, the mass manifested hyperintensity on T1-weighted, T2-weighted, and diffusion-weighted images with some signal voids. PET/CT images demonstrated an intensely hypermetabolic mass in the left thigh and hypermetabolic nodules in lungs.

Conclusion: ASPS should be considered as a possible diagnosis when a slow-growing mass is detected in the soft tissue of the extremities, with hyperintensity and numerous signal voids on T1-weighted, T2-weighted, and diffusion-weighted images and intense F-deoxyglucose uptake on PET/CT. ASPS can have calcifications on CT.
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http://dx.doi.org/10.12998/wjcc.v8.i15.3349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441268PMC
August 2020

Does a change in ventricular size predict a diagnosis of cerebral venous thrombosis-related acute intracranial hypertension? Results of a retrospective imaging study.

Acta Radiol 2019 Oct 12;60(10):1308-1313. Epub 2019 Jan 12.

Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, PR China.

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http://dx.doi.org/10.1177/0284185118823346DOI Listing
October 2019

Colonic Metastasis From Esophageal Squamous Cell Carcinoma Demonstrated With 18F-FDG PET/CT.

Clin Nucl Med 2017 Jun;42(6):456-457

From the Departments of *PET/CT, and †Pathology, The Second Affiliated Hospital of Qingdao University Medical College (Municipal Central Hospital of Qingdao), Qingdao, China.

Metastatic involvement of the colon is extremely rare. We report a 63-year-old man with colonic metastasis from esophageal squamous cell carcinoma. Whole-body F-FDG PET/CT showed abnormal tracer uptakes in the sigmoid colon, which was subsequently confirmed as metastatic from esophageal squamous cell carcinoma.
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http://dx.doi.org/10.1097/RLU.0000000000001656DOI Listing
June 2017

Characteristics of elastofibroma dorsi on PET/CT imaging with (18)F-FDG.

Clin Imaging 2016 Jan-Feb;40(1):110-3. Epub 2015 Aug 15.

Department of PET/CT, The Second Affiliated Hospital of Qingdao University Medical College (Municipal Central Hospital of Qingdao), No127. SiLiu Nan Street, QingDao City, ShanDong Province, 266042, P.R. China.

Purpose: To assess the characteristics of 18F-FDG uptake in elastofibroma dorsi (EFD).

Methods: Seventeen patients with EFD were retrospectively studied.

Results: The mean±S.D. of SUV was 2.29±0.60 (range, 1.2-4.3), and the uptake were Grade 0 in 6, Grade 1 in 12, Grade 2 in 7, and Grade 3 in 1. There is no correlation between lesion volume, SUVmax, and computer tomography value. All EFD lesions showed soft tissue density with low or moderate diffused and homogeneous uptake of 18F-FDG.

Conclusions: Mild and moderate uptake of 18F-FDG is frequently observed in EFD, which should be known to avoid making wrong diagnosis.
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http://dx.doi.org/10.1016/j.clinimag.2015.08.009DOI Listing
August 2016

Myofibroma of the Left Supraspinous Muscle on 18F-FDG PET/CT.

Clin Nucl Med 2016 Apr;41(4):317-8

From the Department of PET/CT, the Second Affiliated Hospital of Qingdao University Medical College (Municipal Central Hospital of Qingdao), Qingdao City, Shandong Province, People's Republic of China.

Myofibroma of the muscle is extremely rare. This report describes a 46-year-old man with myofibroma of the left supraspinous muscle on 18F-FDG PET/CT and includes MRI and 18F-FDG PET/CT findings. Whole-body 18F-FDG PET/CT showed abnormal tracer uptakes in the left supraspinous muscle, which was subsequently confirmed as myofibroma by histopathology.
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http://dx.doi.org/10.1097/RLU.0000000000000980DOI Listing
April 2016

18F-FDG PET/CT Findings of Metastasis to Spongy Body of Penis From Urothelial Carcinoma of Bladder.

Clin Nucl Med 2016 May;41(5):e251-2

From the Department of PET/CT, The Second Affiliated Hospital of QingDao University Medical College, Municipal Central Hospital of QingDao, QingDao City, Shandong Province, People's Republic of China.

The spongy body of the penis metastasis from other primary sites is a rare clinical entity. It is frequently associated with widespread metastatic disease and poor prognosis clinically. We report a case of a 61-year-old man with a previous history of cystectomy due to infiltrating urothelial carcinoma of the bladder 12 months ago and presented with penile shaft swelling pain and hematuria for 3 months. The restaging F-FDG PET/CT scan demonstrated a hypermetabolic mass at his penile shaft. This lesion was confirmed on phallectomy to be infiltrating urothelial carcinoma metastasis from the known primary bladder tumor.
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http://dx.doi.org/10.1097/RLU.0000000000000974DOI Listing
May 2016

Localized Airspace Consolidation of Pulmonary Alveolar Proteinosis Mimicking Malignant Lesions in 18F-FDG PET/CT Imaging: One Case Report.

Clin Nucl Med 2015 Nov;40(11):908-9

From the Department of PET/CT, The Second Affiliated Hospital of QingDao University Medical College, Qingdao City, Shandong Province, People's Republic of China.

Pulmonary alveolar proteinosis is a rare lung disease caused by diffuse, abnormal intra-alveolar surfactant accumulation. Here, we report a case of autoimmune pulmonary alveolar proteinosis with heterogeneous accumulation of F-FDG in both lungs shown on the combined F-FDG PET/CT.
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http://dx.doi.org/10.1097/RLU.0000000000000918DOI Listing
November 2015

Metastatic Malignant Fibrous Histiocytoma in the Stomach: Imaging With 18F-FDG PET/CT.

Clin Nucl Med 2016 Feb;41(2):e123-4

From the Department of PET/CT, The Second Affiliated Hospital of Qingdao University Medical College (Municipal Central Hospital of Qingdao), Qingdao, Shandong Province, People's Republic of China.

Metastatic malignant fibrous histiocytoma (MFH) in the stomach is extremely rare. We report a 73-year-old man with MFH in the left popliteal fossa that metastasized to the stomach. Whole-body F-FDG PET/CT showed abnormal tracer uptakes in the stomach, which was subsequently confirmed as metastatic MFH.
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http://dx.doi.org/10.1097/RLU.0000000000000848DOI Listing
February 2016

Feasible Method to enable clear visualization of suspected bladder cancer with 18F-FDG PET/CT.

Clin Imaging 2014 Sep-Oct;38(5):704-9. Epub 2014 May 9.

Department of PET/CT, The Second Affiliated Hospital of Qingdao University Medical College (Municipal Central Hospital of Qingdao), No127. SiLiu Nan Street, QingDao City, ShanDong Province, 266042, P.R. China.

Purpose: To evaluate value of a new method in detecting bladder lesion with (18)F-FDG PET/CT.

Methods: Routine and delayed scans of 14 patients were retrospectively studied. All these bladder lesions were confirmed by pathology. By increasing display threshold of SUVmax, routine images were analyzed for the second time.

Results: Of 12 (18)F-FDG-avid cases, 10 cases were confirmed to be primary bladder carcinoma, 2 false-positive cases were inflammation. There were 25% positive cases on routine display and 50% on display with increased SUVmax threshold.

Conclusion: The method can effectively increase the sensitivity and accuracy in detecting bladder cancer with (18)F-FDG PET/CT.
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http://dx.doi.org/10.1016/j.clinimag.2014.04.018DOI Listing
May 2015
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