Publications by authors named "Zeinab Salari"

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Microwave-assisted biosynthesis of zinc nanoparticles and their cytotoxic and antioxidant activity.

J Trace Elem Med Biol 2017 Jan 3;39:116-123. Epub 2016 Sep 3.

Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran; Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran. Electronic address:

The present study was designed for microwave assisted synthesis of zinc nanoparticles (Zn NPs) using Lavandula vera leaf extract in the presence of ZnSO (1mM). The biogenic Zn NPs were then characterized using scanning electron microscopy (SEM), energy dispersive X-ray (EDX), X-ray diffraction spectroscopy (XRD), UV-visible spectroscopy, and Fourier transform infrared spectroscopy (FTIR) techniques. Thereafter, the cytotoxic effect of ZnSO and Zn NPs on different cell lines was investigated by MTT-based cytotoxicity assay and their antioxidant properties were assessed using DPPH scavenging activity and reducing power assay. The SEM micrograph showed that the Zn NPs had spherical shape with the size range of 30-80nm. For A549, MCF-7, HT-29, and Caco-2 cell lines treated with Zn NPs, the concentration necessary causing 50% cell death (IC) was found to be 22.3±1.1μgmL, 86±3.7μgmL, 10.9±0.5μgmL, and 56.2±2.8μgmL, respectively. In the case of ZnSO, the same results (IC) were observed at concentration of 81.6±1.3μgmL (A549), 121.0±2.4μgmL (MCF-7), 43.0±1.4μgmL (HT-29), and 85.7±2.3μgmL (Caco-2). The obtained results of antioxidant activity showed that the IC values of butylated hydroxyanisole (BHA) and Zn NPs were 44μgmLand 65.3μgmL, respectively, while ZnSO at concentration of 200μgmL exhibited only 10.9% DPPH radical scavenging effect. Moreover, the reducing power of Zn NPs and BHA were significantly higher than ZnSO (p<0.05). To sum up, application of L. vera leaf extract combined with microwave heating energy led to simple and fast formation of Zn nanostructures exhibited higher antioxidant and cytotoxic activity compared to soluble Zn ions. However, identification of the related mechanisms merit further studies.
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January 2017