Publications by authors named "Zehan Song"

3 Publications

  • Page 1 of 1

The therapeutic promises of NAD boosters.

Cell Metab 2021 Jul;33(7):1274-1275

Program in Metabolic Biology, Nutritional Sciences & Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address:

Numerous preclinical studies implicate the decline in NAD signaling in developing aging- and obesity-associated metabolic disorders. Yoshino et al. (2021) now provide the clinical evidence that an NAD booster increases muscle insulin sensitivity in postmenopausal prediabetic women, validating the therapeutic promises of NAD boosters in humans.
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http://dx.doi.org/10.1016/j.cmet.2021.06.008DOI Listing
July 2021

Stem Cell Metabolism and Diet.

Curr Stem Cell Rep 2020 Dec 28;6(4):119-125. Epub 2020 Oct 28.

Program in Metabolic Biology, Nutritional Sciences & Toxicology, University of California, Berkeley, CA 94720, 119 Morgan Hall, University of California, Berkeley, CA 94720.

Purpose Of Review: Diet has profound impacts on health and longevity. Evidence is emerging to suggest that diet impinges upon the metabolic pathways in tissue-specific stem cells to influence health and disease. Here, we review the similarities and differences in the metabolism of stem cells from several tissues, and highlight the mitochondrial metabolic checkpoint in stem cell maintenance and aging. We discuss how diet engages the nutrient sensing metabolic pathways and impacts stem cell maintenance. Finally, we explore the therapeutic implications of dietary and metabolic regulation of stem cells.

Recent Findings: Stem Cell transition from quiescence to proliferation is associated with a metabolic switch from glycolysis to mitochondrial OXPHOS and the mitochondrial metabolic checkpoint is critically controlled by the nutrient sensors SIRT2, SIRT3, and SIRT7 in hematopoietic stem cells. Intestine stem cell homeostasis during aging and in response to diet is critically dependent on fatty acid metabolism and ketone bodies and is influenced by the niche mediated by the nutrient sensor mTOR.

Summary: Nutrient sensing metabolic pathways critically regulate stem cell maintenance during aging and in response to diet. Elucidating the molecular mechanisms underlying dietary and metabolic regulation of stem cells provides novel insights for stem cell biology and may be targeted therapeutically to reverse stem cell aging and tissue degeneration.
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http://dx.doi.org/10.1007/s40778-020-00180-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992378PMC
December 2020

Open-Ended Video Question Answering via Multi-Modal Conditional Adversarial Networks.

IEEE Trans Image Process 2020 Jan 29. Epub 2020 Jan 29.

As a challenging task in visual information retrieval, open-ended long-form video question answering automatically generates the natural language answer from the referenced video content according to the given question. However, the existing video question answering works mainly focus on the short-form video, which may be ineffectively applied for long-form video question answering directly, due to the insufficiency of modeling the semantic representation of long-form video content. In this paper, we study the problem of open-ended long-form video question answering from the viewpoint of hierarchical multimodal conditional adversarial network learning. We propose the hierarchical attentional encoder network to learn the joint representation of long-form video content and given question with adaptive video segmentation. We then devise the reinforced decoder network to generate the natural language answer for openended video question answering with multi-modal conditional adversarial network learning. We construct three large-scale open-ended video question answering datasets. The extensive experiments validate the effectiveness of our method.
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http://dx.doi.org/10.1109/TIP.2020.2963950DOI Listing
January 2020
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