Publications by authors named "Ze Wang"

349 Publications

Rate-dependent depression is impaired in amyotrophic lateral sclerosis.

Neurol Sci 2021 Sep 13. Epub 2021 Sep 13.

Department of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, 160 Pujian Road, Pudong, Shanghai, 200127, China.

Objective: We investigated rate-dependent depression (RDD) of the Hoffman reflex (H-reflex) in patients with amyotrophic lateral sclerosis (ALS), a degenerative disease with ventral horn involvement.

Patients And Methods: In this case-control study, we enrolled 27 patients with ALS and 30 matched healthy control subjects. Clinical and electrophysiological assessments, as well as RDD in response to various stimulation frequencies (0.5 Hz, 1 Hz, 3 Hz and 5 Hz), were compared between groups. Multiple clinical and electrophysiological factors were also explored to determine any underlying associations with RDD.

Results: The ALS group showed a significant loss of RDD across all frequencies compared to the control group, most notably following 1 Hz stimulation (19.1 ± 20.3 vs. 34.0 ± 13.7%, p = 0.003). Among factors that might influence RDD, the enlargement of the motor unit potential (MUP) showed a significant relationship with RDD following multifactor analysis of variance (p = 0.007) and Pearson correlation analysis (ρ =  - 0.70, p < 0.001), while various upper motor neuron manifestations were not correlated with RDD values (p > 0.05).

Conclusion: We report a loss of RDD in patients with ALS. The strong correlation detected between the RDD deficit and increased MUP suggests that RDD is a sensitive indicator of underlying spinal disinhibition in ALS.

Trial Registration: ChiCTR2000038848, 10/7/2020 (retrospectively registered), http://www.chictr.org.cn/ .
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http://dx.doi.org/10.1007/s10072-021-05596-2DOI Listing
September 2021

N-acetyl cysteine administration affects cerebral blood flow as measured by arterial spin labeling MRI in patients with multiple sclerosis.

Heliyon 2021 Jul 16;7(7):e07615. Epub 2021 Jul 16.

Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USA.

Background: The purpose of this study was to explore if administration of N-acetyl-cysteine (NAC) in patients with multiple sclerosis (MS) resulted in altered cerebral blood flow (CBF) based on Arterial Spin Labeling (ASL) magnetic resonance imaging (MRI).

Methods: Twenty-three patients with mild to moderate MS, (17 relapsing remitting and 6 primary progressive) were randomized to either NAC plus standard of care (N = 11), or standard of care only (N = 12). The experimental group received NAC intravenously (50 mg/kg) once per week and orally (500mg 2x/day) the other six days. Patients in both groups were evaluated initially and after 2 months (of receiving the NAC or waitlist control) with ASL MRI to measure CBF. Clinical symptom questionnaires were also completed at both time points.

Results: The CBF data showed significant differences in several brain regions including the pons, midbrain, left temporal and frontal lobe, left thalamus, right middle frontal lobe and right temporal/hippocampus (p < 0.001) in the MS group after treatment with NAC, when compared to the control group. Self-reported scores related to cognition and attention were also significantly improved in the NAC group as compared to the control group.

Conclusions: The results of this study suggest that NAC administration alters resting CBF in MS patients, and this is associated with qualitative improvements in cognition and attention. Given these findings, large scale efficacy studies will be of value to determine the potential clinical impact of NAC over the course of illness in patients with MS, as well as the most effective dosages and differential effects across subpopulations.
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http://dx.doi.org/10.1016/j.heliyon.2021.e07615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327674PMC
July 2021

Physicochemical, biological properties, and flavour profile of Rosa roxburghii Tratt, Pyracantha fortuneana, and Rosa laevigata Michx fruits: A comprehensive review.

Food Chem 2022 Jan 1;366:130509. Epub 2021 Jul 1.

Department of Biopharmaceuticals and Materials Engineering, Zhuhai Campus Zunyi Medical University, Zhuhai, Guangdong, China; School of Pharmacy, Guizhou Medical University, Guiyang, Guizhou, China. Electronic address:

In China, three Rosaceae fruits with distinctive flavours and functions have recently been transformed from edible plants into standardised juice or beverage products. To enhance the development of these fruit products, the results and conclusions from various investigations of the chemical and biological properties of fruits should be summarised. Based on industrial advances, there are still some limitation in the research and development of these fruit products that need to be addressed. Therefore, in this report, we provided a comprehensive and rigorous review to summarise critical data from phytochemical and biological investigations and from flavour profiles and industrial development of these fruit products. Our goal is to provide insights into recent research findings in order to advance studies and developments of products of these flavourful fruits from a reasonable perspective.
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http://dx.doi.org/10.1016/j.foodchem.2021.130509DOI Listing
January 2022

Disintegrating spatial networks based on region centrality.

Chaos 2021 Jun;31(6):061101

International Academic Center of Complex Systems, Beijing Normal University, Zhuhai 519087, People's Republic of China.

Finding an optimal strategy at a minimum cost to efficiently disintegrate a harmful network into isolated components is an important and interesting problem, with applications in particular to anti-terrorism measures and epidemic control. This paper focuses on optimal disintegration strategies for spatial networks, aiming to find an appropriate set of nodes or links whose removal would result in maximal network fragmentation. We refer to the sum of the degree of nodes and the number of links in a specific region as region centrality. This metric provides a comprehensive account of both topological properties and geographic structure. Numerical experiments on both synthetic and real-world networks demonstrate that the strategy is significantly superior to conventional methods in terms of both effectiveness and efficiency. Moreover, our strategy tends to cover those nodes close to the average degree of the network rather than concentrating on nodes with higher centrality.
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http://dx.doi.org/10.1063/5.0046731DOI Listing
June 2021

Visual assay of Escherichia coli O157:H7 based on an isothermal strand displacement and hybrid chain reaction amplification strategy.

Anal Methods 2021 08 8;13(30):3379-3385. Epub 2021 Jul 8.

School of Life Science and Technology, Changchun University of Science and Technology, Changchun 130022, China.

Here, we describe a simple, sensitive, and enzyme-free method for visual point-of-care detection of 16S rRNA of Escherichia coli O157:H7 based on an isothermal strand displacement-hybrid chain reaction (ISD-HCR) and lateral flow strip (LFS). In this study, the secondary structure of 16S rRNA of E. coli O157:H7 was unwound by two helper oligonucleotides to expose the single-strand-specific nucleic acid sequence. The free specific sequence promoted the toehold-mediated strand displacement reaction to output a large number of FITC-labeled single-stranded DNA probes (capture probe [CP]). The 3'-end sequence of the reporter probe propagated a chain reaction of hybridization events between the two hairpin probes modified with biotin to form long nicked DNA polymers with multiple biotins (RP-HCR complexes); the free CP and RP-HCR complexes then form CP/RP-HCR complexes. The biotin-labeled double-stranded DNA CP/RP-HCR polymers then introduced numerous streptavidin (SA)-labeled gold nanoparticles (AuNPs) on the LFS. The accumulation of AuNPs produced a characteristic red band, which enabled visual detection of changes in the signal of 16S rRNA of E. coli O157:H7. The current approach could detect E. coli O157:H7 at concentrations as low as 10 CFU mL without instrumentation. This approach thus provides a simple, sensitive, and low-cost tool for point-of-care detection of pathogenic bacteria, especially in resource-limited countries.
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http://dx.doi.org/10.1039/d1ay00644dDOI Listing
August 2021

An electrochemical biosensor for the detection of pathogenic bacteria based on dual signal amplification of Cu(PO)-mediated click chemistry and DNAzymes.

Analyst 2021 Jul;146(15):4841-4847

Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Changchun 130122, China.

A novel electrochemical biosensor for detecting pathogenic bacteria was designed based on specific magnetic separation and highly sensitive click chemistry. Instead of enzyme-antibody conjugates, organic-inorganic hybrid nanoflowers [concanavalin A (Con A)-Cu3(PO4)2] were used as the signal probe of the sandwich structure. The inorganic component, the copper ions of hybrid nanoflowers, was first used to amplify signal transduction for enzyme-free detection. Sodium ascorbate could dissolve Cu3(PO4)2 of the signal probe to produce Cu2+, which was subsequently converted to Cu+, triggering the Cu+-catalyzed alkyne-azide cycloaddition (CuAAC) reaction between azide-functionalized ssDNA (a fragment of the DNAzyme-containing sequence) and alkyne-functionalized ssDNA immobilized onto the electrode surface. As a result, the DNAzyme was immobilized onto the gold electrode, which produced a positive and stable electrical signal. An exceptional linear relationship was observed between the electrical signal and the concentration of Salmonella typhimurium (101-107 CFU mL-1) with a detection limit of 10 CFU mL-1. The developed electrochemical biosensor based on dual signal amplification of Cu3(PO4)2-mediated click chemistry and DNAzymes exhibited good results in detecting S. typhimurium in milk samples.
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http://dx.doi.org/10.1039/d1an00982fDOI Listing
July 2021

The Systematic Bias of Entropy Calculation in the Multi-Scale Entropy Algorithm.

Authors:
Jue Lu Ze Wang

Entropy (Basel) 2021 May 24;23(6). Epub 2021 May 24.

Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Entropy indicates irregularity or randomness of a dynamic system. Over the decades, entropy calculated at different scales of the system through subsampling or coarse graining has been used as a surrogate measure of system complexity. One popular multi-scale entropy analysis is the multi-scale sample entropy (MSE), which calculates entropy through the sample entropy (SampEn) formula at each time scale. SampEn is defined by the "logarithmic likelihood" that a small section (within a window of a length m) of the data "matches" with other sections will still "match" the others if the section window length increases by one. "Match" is defined by a threshold of r times standard deviation of the entire time series. A problem of current MSE algorithm is that SampEn calculations at different scales are based on the same matching threshold defined by the original time series but data standard deviation actually changes with the subsampling scales. Using a fixed threshold will automatically introduce systematic bias to the calculation results. The purpose of this paper is to mathematically present this systematic bias and to provide methods for correcting it. Our work will help the large MSE user community avoiding introducing the bias to their multi-scale SampEn calculation results.
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http://dx.doi.org/10.3390/e23060659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225042PMC
May 2021

8a, a New Acridine Antiproliferative and Pro-Apoptotic Agent Targeting HDAC1/DNMT1.

Int J Mol Sci 2021 May 24;22(11). Epub 2021 May 24.

Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800, China.

Epigenetic therapy using histone deacetylase (HDAC) inhibitors has become an attractive project in new drug development. However, DNA methylation and histone acetylation are important epigenetic ways to regulate the occurrence and development of leukemia. Given previous studies, -(2-aminophenyl)benzamide acridine (), as a histone deacetylase 1 (HDAC1) inhibitor, induces apoptosis and shows significant anti-proliferative activity against histiocytic lymphoma U937 cells. HDAC1 plays a role in the nucleus, which we confirmed by finding that entered the nucleus. Subsequently, we verified that mainly passes through the endogenous (mitochondrial) pathway to induce cell apoptosis. From the protein interaction data, we found that also affected the expression of DNA methyltransferase 1 (DNMT1). Therefore, an experiment was performed to assess the binding of to DNMT1 at the molecular and cellular levels. We found that the binding strength of to DNMT1 enhanced in a dose-dependent manner. Additionally, inhibits the expression of mRNA and its protein. These findings suggested that the anti-proliferative and pro-apoptotic activities of against leukemia cells were achieved by targeting HDAC1 and DNMT1.
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http://dx.doi.org/10.3390/ijms22115516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197214PMC
May 2021

Seeing through Events: Real-Time Moving Object Sonification for Visually Impaired People Using Event-Based Camera.

Sensors (Basel) 2021 May 20;21(10). Epub 2021 May 20.

National Engineering Research Center of Optical Instrumentation, Zhejiang University, Hangzhou 310058, China.

Scene sonification is a powerful technique to help Visually Impaired People (VIP) understand their surroundings. Existing methods usually perform sonification on the entire images of the surrounding scene acquired by a standard camera or on the priori static obstacles acquired by image processing algorithms on the RGB image of the surrounding scene. However, if all the information in the scene are delivered to VIP simultaneously, it will cause information redundancy. In fact, biological vision is more sensitive to moving objects in the scene than static objects, which is also the original intention of the event-based camera. In this paper, we propose a real-time sonification framework to help VIP understand the moving objects in the scene. First, we capture the events in the scene using an event-based camera and cluster them into multiple moving objects without relying on any prior knowledge. Then, sonification based on MIDI is enabled on these objects synchronously. Finally, we conduct comprehensive experiments on the scene video with sonification audio attended by 20 VIP and 20 Sighted People (SP). The results show that our method allows both participants to clearly distinguish the number, size, motion speed, and motion trajectories of multiple objects. The results show that our method is more comfortable to hear than existing methods in terms of aesthetics.
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http://dx.doi.org/10.3390/s21103558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161033PMC
May 2021

Effect of Orlistat on Live Birth Rate in Overweight or Obese Women Undergoing IVF-ET: A Randomized Clinical Trial.

J Clin Endocrinol Metab 2021 Aug;106(9):e3533-e3545

Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University; The Key Laboratory of Reproductive Endocrinology of Ministry of Education; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, Shandong Province, 250001,China.

Context: Obesity management prior to infertility treatment remains a challenge. To date, results from randomized clinical trials involving weight loss by lifestyle interventions have shown no evidence of improved live birth rate.

Objective: This work aimed to determine whether pharmacologic weight-loss intervention before in vitro fertilization and embryo transfer (IVF-ET) can improve live birth rate among overweight or obese women.

Methods: We conducted a randomized, double-blinded, placebo-controlled trial across 19 reproductive medical centers in China, from July 2017 to January 2019. A total of 877 infertile women scheduled for IVF who had a body mass index of 25 or greater were randomly assigned to receive orlistat (n = 439) or placebo (n = 438) treatment for 4 to 12 weeks. The main outcome measurement was the live birth rate after fresh ET.

Results: The live birth rate was not significantly different between the 2 groups (112 of 439 [25.5%] with orlistat and 112 of 438 [25.6%] with placebo; P = .984). No significant differences existed between the groups as to the rates of conception, clinical pregnancy, or pregnancy loss. A statistically significant increase in singleton birth weight was observed after orlistat treatment (3487.50 g vs 3285.17 g in the placebo group; P = .039). The mean change in body weight during the intervention was -2.49 kg in the orlistat group, as compared to -1.22 kg in the placebo group, with a significant difference (P = .005).

Conclusion: Orlistat treatment, prior to IVF-ET, did not improve the live birth rate among overweight or obese women, although it was beneficial for weight reduction.
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http://dx.doi.org/10.1210/clinem/dgab340DOI Listing
August 2021

Large-Scale Bio-Inspired Flexible Antireflective Film with Scale-Insensitivity Arrays.

ACS Appl Mater Interfaces 2021 May 11;13(19):23103-23112. Epub 2021 May 11.

Key Laboratory of Bionic Engineering, Ministry of Education, Jilin University, Changchun 130022, China.

Natural creatures can always provide perfect strategies for excellent antireflection (AR), which is valuable for photovoltaic industry, optical devices, and flexible displays. However, limited by precision, it is still difficult to guarantee the consistency between the artificial structures and the original biological structures. Here, a novel large-scale flexible AR film is inspired by the cicada wings and successfully fabricated with a recycled template. On the one hand, the adjustable structures on porous templates make it possible to optimize the design of AR structure parameters toward the practical demand. On the other hand, it breaks the limitation of the biological organism size, accomplishing the replication of AR nanostructure units in a large scale. Interestingly, even if the film is covered by enlarged dome cone arrays, it still maintains almost perfect AR property, achieving excellent scale-insensitivity AR performance. This work numerically and experimentally investigates its scale-insensitivity AR performance in detail. Compared with subwavelength nanocones, enlarged cones change the original optical behaviors, and the proportion of transmitted light is reduced while scattering and absorption increase. Based on this, these bio-inspired scale-insensitivity AR arrays could be used in flexible displays, photothermic conversion, solar cells, and so on.
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http://dx.doi.org/10.1021/acsami.1c02046DOI Listing
May 2021

Longitudinal Cerebral Blood Flow Changes in Normal Aging and the Alzheimer's Disease Continuum Identified by Arterial Spin Labeling MRI.

J Alzheimers Dis 2021 ;81(4):1727-1735

Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.

Background: Cross-sectional studies have shown lower cerebral blood flow (CBF) in Alzheimer's disease (AD), but longitudinal CBF changes in AD are still unknown.

Objective: To reveal the longitudinal CBF changes in normal control (NC) and the AD continuum using arterial spin labeling perfusion magnetic resonance imaging (ASL MRI).

Methods: CBF was calculated from two longitudinal ASL scans acquired 2.22±1.43 years apart from 140 subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI). At the baseline scan, the cohort contained 41 NC, 74 mild cognitive impairment patients (MCI), and 25 AD patients. 21 NC converted into MCI and 17 MCI converted into AD at the follow-up. Longitudinal CBF changes were assessed using paired-t test for non-converters and converters separately at each voxel and in the meta-ROI. Age and sex were used as covariates.

Results: CBF reductions were observed in all subjects. Stable NC (n = 20) showed CBF reduction in the hippocampus and precuneus. Stable MCI patients (n = 57) showed spatially more extended CBF reduction patterns in hippocampus, middle temporal lobe, ventral striatum, prefrontal cortex, and cerebellum. NC-MCI converters showed CBF reduction in hippocampus and cerebellum and CBF increase in caudate. MCI-AD converters showed CBF reduction in hippocampus and prefrontal cortex. CBF changes were not related with longitudinal neurocognitive changes.

Conclusion: Normal aging and AD continuum showed common longitudinal CBF reductions in hippocampus independent of disease and its conversion. Disease conversion independent longitudinal CBF reductions escalated in MCI subjects.
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http://dx.doi.org/10.3233/JAD-210116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217256PMC
September 2021

Aminoguanidine ameliorates ovariectomy-induced neuronal deficits in rats by inhibiting AGE-mediated Aβ production.

Acta Neurobiol Exp (Wars) 2021 ;81(1):10-20

Department of Nephropathy , Beijing Hospital of Traditional Chinese Medicine , Capital Medical University , Beijing , China.

Advanced glycation end products (AGEs) have been reported to cause neurodegeneration, senile plaque formation and spatial learning and memory deficits. There is much evidence describing the beneficial effects of aminoguanidine (AG) on the central nervous system; AG is able to inhibit the receptor for AGEs and beta-amyloid (Aβ) deposition in the brain, thus preventing cognitive decline and neurodegeneration. In this study, we investigated whether AG protects against ovariectomy-induced neuronal deficits and Aβ deposition in rats. Animals in the ovariectomy group (OVX) group, and those in the OVX+AG group were treated with AG (100 mg/kg/day) for 8 weeks. Learning and memory were evaluated using the electric Y maze. AGE and Aβ biochemical assessments were performed using enzyme-linked immunosorbent assay (ELISA) kits. Furthermore, evaluations of brain amyloid precursor protein 695 (APP) mRNA expression by RT-PCR and AGE expression by immunohistochemistry were carried out. Ovariectomized rats exhibited memory impairment and Aβ production disorder with upregulated APP mRNA and AGE expression levels. AG pretreatment relieved the ovariectomy-induced learning and memory disorder and significantly ameliorated the Aβ production disturbance and AGE generation. Additionally, pathological changes in morphology were also significantly recovered. Our data reveal that AG plays a potentially neuroprotective role against ovariectomy-induced learning and cognitive impairment and Aβ production disorder.

Advanced glycation end products (AGEs) have been reported to cause neurodegeneration, senile plaque formation and spatial learning and memory deficits. There is much evidence describing the beneficial effects of aminoguanidine (AG) on the central nervous system; AG is able to inhibit the receptor for AGEs and beta-amyloid (Aβ) deposition in the brain, thus preventing cognitive decline and neurodegeneration. In this study, we investigated whether AG protects against ovariectomy-induced neuronal deficits and Aβ deposition in rats. Animals in the ovariectomy group (OVX) group, and those in the OVX+AG group were treated with AG (100 mg/kg/day) for 8 weeks. Learning and memory were evaluated using the electric Y maze. AGE and Aβ biochemical assessments were performed using enzyme-linked immunosorbent assay (ELISA) kits. Furthermore, evaluations of brain amyloid precursor protein 695 (APP) mRNA expression by RT-PCR and AGE expression by immunohistochemistry were carried out. Ovariectomized rats exhibited memory impairment and Aβ production disorder with upregulated APP mRNA and AGE expression levels. AG pretreatment relieved the ovariectomy-induced learning and memory disorder and significantly ameliorated the Aβ production disturbance and AGE generation. Additionally, pathological changes in morphology were also significantly recovered. Our data reveal that AG plays a potentially neuroprotective role against ovariectomy-induced learning and cognitive impairment and Aβ production disorder.
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http://dx.doi.org/10.21307/ane-2021-002DOI Listing
January 2021

Clinical application of a multi-groove silicone drain combined with unidirectional negative-pressure drainage system in single-operating-port video-assisted thoracoscopic lung cancer surgery: a comparison study.

J Int Med Res 2021 Apr;49(4):300060521999766

Department of Thoracic Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, P.R. China.

Objective: To evaluate the effect of a new negative-pressure drainage system in thoracoscopic lung cancer surgery; thereby, providing a new option for postoperative drainage.

Methods: We retrospectively analyzed data for 200 patients who underwent thoracoscopic surgery between May 2018 and October 2019. According to the thoracic drainage method, the patients were divided into the thoracic tube group and the new system group. The epidemiological and clinicopathological data were compared before operation, and the clinical effect of thoracic drainage was compared after operation.

Results: There was no significant difference in epidemiological and clinicopathological data between the two groups. There was also no significant difference in drain removal time, hospital stay, and complication rates between the two groups. However, the incidences of pleural effusion and poor incision healing in the new system group were lower than in the thoracic tube group. Visual analog scale (VAS) scores in the new system group were lower than those in the thoracic tube group at each postoperative interval; therefore, the new system group required less analgesia.

Conclusion: The new system was not inferior to thoracic tubes regarding the drainage effect after thoracoscopic lung cancer surgery. Hence, the system is an alternative to traditional thoracic tubes.
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http://dx.doi.org/10.1177/0300060521999766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8108081PMC
April 2021

IL-1R1 deficiency impairs liver regeneration after 2/3 partial hepatectomy in aged mice.

Turk J Biol 2021 20;45(2):225-234. Epub 2021 Apr 20.

State Key Laboratory Cell Differentiation and Regulation, Henan Normal University, Xinxiang, Henan China.

Inflammation has a dual effect: it can protect the body and destroy tissue and cell as well. The purpose of this experiment was to determine the role of in liver regeneration (LR) after partial hepatectomy (PH) in aged mice. The wild-type (WT, n = 36) and the knockout (KO, n = 36) 24-month-old C57BL/6J mice underwent two-thirds PH; 33 WT mice underwent sham operation. Liver coefficient was calculated by liver/body weight. The mRNA and protein expressions of genes were evaluated by quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting methods, respectively. Compared with WT mice, liver coefficient was lower in the KO aged mice at 168 and 192 h (p = 0.039 and p = 0.027). The mRNA transcription of inflammation-related genes and cell cycle-associated genes decreased or delayed. The protein expressions of proliferation-related marker PCNA and proliferation-associated signaling pathway components JNK1, NF-κB and STAT3 reduced or retarded. There was stronger activation of proapoptotic proteins caspase-3, caspase-8 and BAX in the KO mice at different time points (p < 0.05 or p < 0.01). KO reduced inflammation and caused impaired liver regeneration after 2/3 partial hepatectomy in aged mice. Maintaining proper inflammation may contribute to regeneration after liver partly surgical resection in the elderly.
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http://dx.doi.org/10.3906/biy-2010-51DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068764PMC
April 2021

Comparison of metabolism substances in Cordyceps sinensis and Cordyceps militaris cultivated with tussah pupa based on LC-MS.

J Food Biochem 2021 06 22;45(6):e13735. Epub 2021 Apr 22.

Experimental Teaching Center, Shenyang Normal University, Shenyang, People's Republic of China.

The objective of our study was to compare the chemical composition of Cordyceps sinensis (C. sinensis) and Cordyceps militaris (C. militaris) cultivated with tussah pupa by using metabonomics technology in order to clarify the similarity and difference of the two medicinal materials from the whole metabolite level. The results showed that there were 25 different metabolites among the 69 metabolites that were highly expressed in C. militaris cultivated with tussah pupa compared with C. sinensis in both positive and negative ion modes. Analysis results of partial differential metabolites pathways indicated that 16 differential metabolites were involved in multiple pathways, such as histidine metabolism, arginine biosynthesis, tyrosine metabolism, glyoxylate and dicarboxylate metabolism, phenylpropanoid biosynthesis, pyruvate metabolism, etc. Therefore, the composition of C. militaris cultivated with tussah pupa had significant advantage comparing with C. sinensis, which demonstrated that high-priced C. sinensis could be substituted with C. militaris cultivated with tussah pupa to some extent. PRACTICAL APPLICATIONS: This study comprehensively compared the chemical composition of Cordyceps sinensis (C. sinensis) and Cordyceps militaris (C. militaris) cultivated with tussah pupa by using metabonomics technology in order to clarify the similarity and difference of the two medicinal materials from the whole metabolite level. The experimental results provide a theoretical basis and scientific support for whether C. sinensis can be substituted with C. militaris cultivated with tussah pupa in clinical practice.
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http://dx.doi.org/10.1111/jfbc.13735DOI Listing
June 2021

Modified superior oblique intrasheath tenectomy in A-pattern with superior oblique overaction.

BMC Ophthalmol 2021 Apr 21;21(1):184. Epub 2021 Apr 21.

Nanjing South East Eye Hospital, 36 Muxuyuan Street, 210007, Nanjing, China.

Background: To evaluate the effect of modified superior oblique intrasheath tenectomy (MSOIT) on superior oblique overaction (SOOA) with A-pattern.

Methods: We retrospectively reviewed the data of 66 patients (130 eyes) with SOOA and A-pattern underwent MSOIT at the nasal border of the superior rectus under an operating microscope between January 1, 2004 and December 31, 2018. The superior oblique (SO) tendon fibres were resected, and the sheath was preserved in all patients. The preoperative and postoperative SOOA, objective torsion, ocular motility, and A-pattern deviation findings were compared. The correlation between the preoperative A-pattern deviation and the corrected deviation was analysed. The average follow-up period was 33.45 ± 29.88 (range: 12-122) months.

Results: The mean SOOA deviation improved from 2.95 ± 0.54 to 0.34 ± 0.55 (P < 0.001), while the A-pattern deviation difference between upgaze and downgaze improved from 23.15 ± 7.59 prism diopters (PD) to 3.50 ± 2.90 PD (P < 0.001). The average objective fundus intorsion value improved from + 2.96 ± 0.58 to + 0.38 ± 0.60 (P < 0.001). The magnitude of correction in A-pattern was significantly correlated with the preoperative severity of A-pattern (r = 0.812, P < 0.001).

Conclusions: MSOIT at the nasal border of the superior rectus (SR) under an operating microscope is safe and yields beneficial outcomes in patients with SOOA and A-pattern.
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http://dx.doi.org/10.1186/s12886-021-01942-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8059248PMC
April 2021

Broader-Band and Flexible Antireflective Films with the Window-like Structures Inspired by the Backside of Butterfly Wing Scales.

ACS Appl Mater Interfaces 2021 Apr 19;13(16):19450-19459. Epub 2021 Apr 19.

Key Laboratory of Bionic Engineering, Ministry of Education, Jilin University, Changchun 130022, China.

Antireflective performance is critical for most optical devices, such as the efficient solar energy utilization in photovoltaic cells of an aerospace craft and optical displays of scientific precise equipment. Therein, outstanding broad-band antireflection is one of the most crucial properties for antireflection films (ARFs). Unfortunately, it is still a challenging work to realize perfect "broader-band" antireflection because both the low refractive indices materials and time-consuming nanotexturing technologies are required in the fabricating process. Even in this case, a broader-band and flexible ARF with hierarchical structures is successfully developed, which is inspired by butterfly wing scales. First, the butterfly wings surface is treated with acid and stuck on a clean glass. Now, all the scales on the wings will form a strong adhesion with the glass substrate. Then, the wings are removed and the scales are left on the glass slide. Now the backside of scales is facing outward, the backside structures of the scales are coincidentally used as the template. Finally, the structure is replicated and the ARF with a controllable thickness is successfully fabricated by rotating PDMS on the biological template. In this work, the bionic ARFs realize the transmission of nearly 90% and more than 90% in the visible light and infrared region. It enhanced transmission to 13% under standard illumination compared with flat PDMS films of the same thickness. Furthermore, the ARF is flexible enough that it could bend nearly 180° to meet the special antireflection requirements in some extreme conditions. It is expected that this bioinspired AR film could revolutionize the technologies of broader-band antireflective materials and impact numerous applications from glass displays to optoelectronic devices.
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http://dx.doi.org/10.1021/acsami.1c01352DOI Listing
April 2021

Telitacicept Following Plasma Exchange in the Treatment of Subjects With Recurrent NMOSD: Study Protocol for a Single-Center, Single-Arm, Open-Label Study.

Front Neurol 2021 18;12:596791. Epub 2021 Mar 18.

Department of Neurology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune demyelinating disease that recurrently relapses and leads to severe disability. The available choices for disease prevention are few or intolerable. Previous studies suggested that telitacicept may provide a promising therapeutic strategy for autoimmune diseases involving B cells. Therefore, this study aims to assess the effectiveness and safety of telitacicept for recurrent NMOSD. We will perform a single-arm, single-center, open-label, specialist study with a total enrollment of eight participants. The treatment regimen includes plasma exchange three times and subcutaneous injection of telitacicept for 46 cycles, with a total period of 48 weeks. The primary endpoint is the time to first recurrence after enrollment. Secondary endpoints are Expanded Disability Status Scale (EDSS) score, Opticospinal Impairment Scale (OSIS) score, Hauser Ambulation Index, number of lesions on MRI, and changes in visual evoked potential (VEP), optical coherence tomography (OCT) and immunologic status. All adverse events after medication will be documented and investigated. This study will explore the safety and effectiveness of telitacicept following plasma exchange regarding the time to recurrence in neuromyelitis optica spectrum disorder (NMOSD) for the first time. Chictr.org.cn, identifier ChiCTR1800019427.
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http://dx.doi.org/10.3389/fneur.2021.596791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044936PMC
March 2021

A clinical scoring system for predicting tumor recurrence after percutaneous radiofrequency ablation for 3 cm or less hepatocellular carcinoma.

Sci Rep 2021 Apr 15;11(1):8275. Epub 2021 Apr 15.

Department of Hepatobiliary Surgery, Zhongshan Hospital Affiliated to Sun Yat-Sen University, Zhongshan City, 528400, Guangdong Province, China.

Preoperative prediction of tumor recurrence after radiofrequency ablation (RFA) in patients with early hepatocellular carcinoma (HCC) is helpful for clinical decision-making before treatment. A total of 162 patients with HCC of 3 cm or less who were completely ablated by percutaneous RFA were divided into a derivation cohort (n = 108) and a validation cohort (n = 54). Based on X-Tiles software, Kaplan-Meier curve analysis and COX multivariate analysis to obtain valuable predictive indicators, a clinical scoring system for predicting tumor recurrence was established. In the verall cohort, derivation cohort and validation cohort, we found circulating tumor cells (CTC) > 2/3.2 mL, alpha-fetoprotein (AFP) > 20 ng/mL, and des-γ-carboxyprothrombin (DCP) > 40 mAU/mL, maximum tumor diameter > 20 mm, and the number of multiple tumors (≥ 2) are independent risk factors affecting tumor recurrence. Each independent risk factor was assigned a score of 1 to construct a predictive clinical scoring system, and X-Tiles software was used to divide the clinical score into a low-risk group (0 score-1 score), a medium-risk group (2 scores-3 scores), and a high-risk group (4 scores-5 scores). The cumulative tumor recurrence rates of patients in the low-risk group, middle-risk group, and high-risk group in 1 year, 2 years, and 3 years were 19.4%/27.5%/30.9%, 37.0%/63.2%/79.9% and 68.2%/100%/100%, respectively (Low-risk group vs medium-risk group: P < 0.001; medium-risk group vs high-risk group: P < 0.001). This clinical scoring system can predict the prognosis of patients with HCC of 3 cm or smaller undergoing percutaneous RFA, which has certain application value for making preoperative clinical decisions.
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http://dx.doi.org/10.1038/s41598-021-87782-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050297PMC
April 2021

[Analysis on the defensive function of defensive in (')].

Zhongguo Zhen Jiu 2021 Mar;41(3):343-7

Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.

The defensive function of defensive in ( ') includes the effect of immune system of human body against the pathogen invasion. According to the basic research, it is believed that the circulation of defensive in meridian is interpreted as the flow of interstitial fluid in the low hydraulic resistance channel that is overlapped with lymphatic vessels, transporting the antigen information from interstitium to lymph nodes and generating adaptive immune response. Enhancing meridian circulation and promoting the flow of interstitial fluid may improve the immunity, which demonstrating the thought of traditional Chinese meridian as "pathogens failing to invade the body when the anti-pathogenic is strong enough inside".
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http://dx.doi.org/10.13703/j.0255-2930.20200316-0003DOI Listing
March 2021

Neurofascin antibodies in chronic inflammatory demyelinating polyradiculoneuropathy: from intrinsic genetic background to clinical manifestations.

Neurol Sci 2021 Jun 29;42(6):2223-2233. Epub 2021 Mar 29.

Department of Neurology, Renji Hospital Shanghai Jiaotong University School of Medicine, 160 Pujian Road, Shanghai, 200127, China.

There are bunch of autoantibodies, particularly autoantibodies against proteins located at the node of Ranvier, have been discovered and transformed the clinical management of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Neurofascin (NF) plays an important role in both the nodal and paranodal regions of the node of Ranvier. In this review, we focus on the two characteristic forms of neurofascin: NF186 and NF155, comparing the similarities and differences between them, reviewing the current knowledge on genetic backgrounds, pathogenesis, clinical manifestations, and management of patients with anti-neurofascin positive CIDP. Autoantibodies against neurofascin were mainly IgG4 isotype. Mutation of NFASC gene in human causes severe neurodevelopment disorders, and HLA DRB1*15 may be a strong risk factor for the development of anti-NF155 antibodies. Motor impairment, sensory ataxia, and tremor were the typical presentations of patients with anti-NF155+ CIDP, while tetraplegia and cranial nerve involvement were more common in patients with anti-NF186+ CIDP. Recent studies have depicted a relatively clear picture of anti-NF155+ CIDP, and the strong clinical correlation of NF186 with CIDP remains unclear. The genetic background of neurofascin will assist in future explorations.
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http://dx.doi.org/10.1007/s10072-021-05220-3DOI Listing
June 2021

BiVO/[email protected] superparticles for tumor multimodal imaging and synergistic therapy.

J Nanobiotechnology 2021 Mar 29;19(1):90. Epub 2021 Mar 29.

State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, 130012, People's Republic of China.

Background: Despite tremendous progress has been achieved in tumor theranostic over the past decade, accurate identification and complete eradication of tumor cells remain a great challenge owing to the limitation of single imaging modality and therapeutic strategy.

Results: Herein, we successfully design and construct BiVO/[email protected] (PDA) superparticles (SPs) for computed tomography (CT)/photoacoustic (PA)/magnetic resonance (MR) multimodal imaging and radiotherapy (RT)/photothermal therapy (PTT) synergistic therapy toward oral epithelial carcinoma. On the one hand, BiVO NPs endow BiVO/[email protected] SPs with impressive X-ray absorption capability due to the high X-ray attenuation coefficient of Bi, which is beneficial for their utilization as radiosensitizers for CT imaging and RT. On the other hand, FeO NPs impart BiVO/[email protected] SPs with the superparamagnetic property as a T-weighted contrast agent for MR imaging. Importantly, the aggregation of FeO NPs in SPs and the presence of PDA shell greatly improve the photothermal conversion capability of SPs, making BiVO/[email protected] SPs as an ideal photothermal transducer for PA imaging and PTT. By integrating advantages of various imaging modalities (CT/PA/MR) and therapeutic strategies (RT/PTT), our BiVO/[email protected] SPs exhibit the sensitive multimodal imaging feature and superior synergistic therapeutic efficacy on tumors.

Conclusions: Since there are many kinds of building blocks with unique properties appropriating for self-assembly, our work may largely enrich the library of nanomateirals for tumor diagnosis and treatment.
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http://dx.doi.org/10.1186/s12951-021-00802-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008624PMC
March 2021

From PNS to CNS: characteristics of anti-neurofascin 186 neuropathy in 16 cases.

Neurol Sci 2021 Mar 15. Epub 2021 Mar 15.

Department of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, 160 Pujian Road, Pudong, Shanghai, 200127, China.

Introduction: Neurofascin (NF) is critical for the formation and maintenance of Ranvier nodes. NF186, the neuronal form of NF, localizes in the initial segment of axon and Ranvier node. NF186 antibody has been detected in demyelinating diseases of both central nervous system (CNS) and peripheral nervous system (PNS).

Aims: To evaluate the clinical features of patients with anti-NF186 IgG neuropathy.

Methods: Sixteen patients (16/138) with serum-positive anti-NF186 IgG were included and divided into groups of either CNS or PNS-involved according to their clinical manifestations. Anti-NF186 IgG was detected by cell-based assays.

Results: In 7 patients who were confirmed to have CNS involvement, the most frequent symptoms were dizziness (57%) and vision impairment (43%); lesions in centrum semiovale, cerebellum, and meninges were shown by magnetic resonance imaging (MRI). In comparison, limb weakness (78%) and numbness (78%) were the most common symptoms in PNS-involved patients; axonal loss and demyelination were confirmed by nerve conduction examinations. Elevated level of cerebrospinal fluid (CSF) protein was found in 12 cases without statistically significant difference between the CNS and PNS groups. Meanwhile, CSF white blood cell counts were found significantly elevated in CNS-involved patients compared with patients of PNS group. Thirteen patients received immunomodulating treatments, and patients with chronic onset and progressive course showed poor response to the therapies.

Conclusions: Patients with anti-NF186 IgG neuropathy showed no specific symptoms or signs. It is worth noting that quite a few patients show CNS-impaired signs only, and cranial MRI is essential for the screening of CNS involvement.
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http://dx.doi.org/10.1007/s10072-021-05101-9DOI Listing
March 2021

Promotion of tomato growth by the volatiles produced by the hypovirulent strain QT5-19 of the plant gray mold fungus Botrytis cinerea.

Microbiol Res 2021 Jun 20;247:126731. Epub 2021 Feb 20.

State Key Laboratory of Agricultural Microbiology and Key Laboratory of Plant Pathology of Hubei Province, Huazhong Agricultural University, Wuhan, 430070, Hubei, China. Electronic address:

Our previous study identified a hypovirulent strain QT5-19 of Botrytis cinerea, the causal agent of the plant gray mold disease, and found that QT5-19 can produce volatile organic compounds (VOCs) with high antifungal activity and high control efficacy against B. cinerea. However, impact of the QT5-19 VOCs on plant growth remains unknown. This study was conducted to investigate the impact of the QT5-19 VOCs on tomato growth, and to elucidate the mechanisms for the plant growth-promoting (PGP) activity of the QT5-19 VOCs. Results showed that compared to the control treatment, the QT5-19 VOCs significantly (P < 0.05) promoted tomato growth, and the PGP activity of the QT5-19 VOCs acted in dose- and time-dependent manners. Results also showed that the values of photosynthetic assimilation, stomatal conductance and transpiration, water use efficiency and chlorophyll content in the treatments of the QT5-19 VOCs were significantly (P < 0.05) higher than the corresponding values in the control treatment. The QT5-19 VOCs up-regulated expression of the genes for expansins (EXP2, EXP9 and EXP18), IAA (SlIAA1, SlIAA3 and SlIAA9), cytokinins (SlCKX1) and gibberellins in leaves and/or roots, whereas down-regulated expression of the gene ACO1 for ethylene in both organs. Moreover, enhanced accumulation of auxins and decreased accumulation of ethylene were observed in tomato roots in the treatment of the QT5-19 VOCs, compared to the control treatment. These results suggest that the QT5-19 VOCs probably promote tomato growth through improving photosynthesis and biosynthesis of expansins and IAA, and reducing ethylene biosynthesis. This study suggests that QT5-19 is a versatile biocontrol control agent.
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http://dx.doi.org/10.1016/j.micres.2021.126731DOI Listing
June 2021

Progress in the Development of Eukaryotic Elongation Factor 2 Kinase (eEF2K) Natural Product and Synthetic Small Molecule Inhibitors for Cancer Chemotherapy.

Int J Mol Sci 2021 Feb 27;22(5). Epub 2021 Feb 27.

Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800, China.

Eukaryotic elongation factor 2 kinase (eEF2K or Ca2+/calmodulin-dependent protein kinase, CAMKIII) is a new member of an atypical α-kinase family different from conventional protein kinases that is now considered as a potential target for the treatment of cancer. This protein regulates the phosphorylation of eukaryotic elongation factor 2 (eEF2) to restrain activity and inhibit the elongation stage of protein synthesis. Mounting evidence shows that eEF2K regulates the cell cycle, autophagy, apoptosis, angiogenesis, invasion, and metastasis in several types of cancers. The expression of eEF2K promotes survival of cancer cells, and the level of this protein is increased in many cancer cells to adapt them to the microenvironment conditions including hypoxia, nutrient depletion, and acidosis. The physiological function of eEF2K and its role in the development and progression of cancer are here reviewed in detail. In addition, a summary of progress for in vitro eEF2K inhibitors from anti-cancer drug discovery research in recent years, along with their structure-activity relationships (SARs) and synthetic routes or natural sources, is also described. Special attention is given to those inhibitors that have been already validated in vivo with the overall aim to provide reference context for the further development of new first-in-class anti-cancer drugs that target eEF2K.
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http://dx.doi.org/10.3390/ijms22052408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957638PMC
February 2021

Recent Advances in Small Peptides of Marine Origin in Cancer Therapy.

Mar Drugs 2021 Feb 19;19(2). Epub 2021 Feb 19.

Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, China.

Cancer is one of the leading causes of death in the world, and antineoplastic drug research continues to be a major field in medicine development. The marine milieu has thousands of biological species that are a valuable source of novel functional proteins and peptides, which have been used in the treatment of many diseases, including cancer. In contrast with proteins and polypeptides, small peptides (with a molecular weight of less than 1000 Da) have overwhelming advantages, such as preferential and fast absorption, which can decrease the burden on human gastrointestinal function. Besides, these peptides are only connected by a few peptide bonds, and their small molecular weight makes it easy to modify and synthesize them. Specifically, small peptides can deliver nutrients and drugs to cells and tissues in the body. These characteristics make them stand out in relation to targeted drug therapy. Nowadays, the anticancer mechanisms of the small marine peptides are still largely not well understood; however, several marine peptides have been applied in preclinical treatment. This paper highlights the anticancer linear and cyclic small peptides in marine resources and presents a review of peptides and the derivatives and their mechanisms.
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http://dx.doi.org/10.3390/md19020115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923226PMC
February 2021

Factor Structure of the PANAS With Bayesian Structural Equation Modeling in a Chinese Sample.

Authors:
Minsun Kim Ze Wang

Eval Health Prof 2021 Mar 4:163278721996794. Epub 2021 Mar 4.

Department of Educational, School and Counseling Psychology, 14716University of Missouri, Columbia, MO, USA.

The Positive and Negative Affect Schedule (PANAS) is the most widely used self-report instrument for assessing affect. However, there are inconsistent findings regarding the factor structure of the PANAS. In this study, we applied Bayesian structural equation modeling (BSEM) to investigate the structure of the PANAS using data from a sample of 893 Chinese middle and high school students. Four models, the orthogonal two-, the oblique two-, the three-, and the bi-factor models were tested with prior specifications including approximately zero cross-loadings and residual covariances. The results indicated that the orthogonal two-factor model specified with informative priors for both cross-loadings and residual correlations has the best model fit. Confirmatory factor analysis with the maximum likelihood estimator (ML-CFA) based on modifications from BSEM analysis showed improved model fit compared to ML-CFA based on frequentist analysis, which is the evidence for the merit of BSEM for addressing misspecifications.
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http://dx.doi.org/10.1177/0163278721996794DOI Listing
March 2021

Effect of Zinc-Doping on the Reduction of the Hot-Carrier Cooling Rate in Halide Perovskites.

Angew Chem Int Ed Engl 2021 May 30;60(19):10957-10963. Epub 2021 Mar 30.

Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Macao SAR, 999078, China.

The fast hot-carrier cooling process in the solar-absorbers fundamentally limits their photon-conversion efficiencies. It is highly desirable to develop a solar absorber with long-lived hot-carriers at sun-illumination intensity, which can be used to develop the hot-carrier solar cells with enhanced efficiency. Herein, we reveal that zinc-doped (0.34 %) halide perovskites have the slower hot-carrier cooling compared with the pristine sample through the transient absorption spectroscopy measurements and theoretical calculations. The hot-carrier energy loss rate at the low photoexcitation level of 10  cm is found to be ≈3 times smaller than that of un-doped perovskites for T=500 K hot carriers, and up to ten times when the hot-carrier temperature approaches the lattice temperature. The incorporation of zinc-dopant into perovskites can reduce the nonadiabatic couplings between conduction bands, which retards the photogenerated hot-carriers relaxation processes. Our findings present a practical strategy to slow down the hot-carrier cooling in perovskites at low carrier densities, which would be invaluable for the further development of practical hot-carrier photovoltaics based on perovskites.
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http://dx.doi.org/10.1002/anie.202100099DOI Listing
May 2021

The neurocognitive correlates of brain entropy estimated by resting state fMRI.

Authors:
Ze Wang

Neuroimage 2021 05 20;232:117893. Epub 2021 Feb 20.

Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 670W. Baltimore St, Baltimore, MD 20201, United States. Electronic address:

Resting state brain activity consumes most of brain energy, likely creating and maintaining a reserve of general brain functionality. The latent reserve if it exists may be reflected by the profound long-range fluctuations of resting brain activity. The long-range temporal coherence (LRTC) can be characterized by resting state fMRI (rsfMRI)-based brain entropy (BEN) mapping. While BEN mapping results have shown sensitivity to neuromodulations or disease conditions, the underlying neuromechanisms especially the associations of BEN or LRTC to neurocognition still remain unclear. To address this standing question and to test a novel hypothesis that resting BEN reflects a latent functional reserve through the link to general functionality, we mapped resting BEN of 862 young adults and comprehensively examined its associations to neurocognitions using data from the Human Connectome Project (HCP). Our results unanimously highlighted two brain circuits: the default mode network (DMN) and executive control network (ECN) through their negative associations of BEN to general functionality, which is independent of age and sex. While BEN in DMN/ECN increases with age, it decreases with education years. These results demonstrated the neurocognitive correlates of resting BEN in DMN/ECN and suggest resting BEN in DMN/ECN as a potential proxy of the latent functional reserve that facilitates general brain functionality and may be enhanced by education.
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http://dx.doi.org/10.1016/j.neuroimage.2021.117893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138544PMC
May 2021
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