Ze'ev A Ronai

Ze'ev A Ronai

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Ze'ev A Ronai

Ze'ev A Ronai

Publications by authors named "Ze'ev A Ronai"

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SIP/CacyBP promotes autophagy by regulating levels of BRUCE/Apollon, which stimulates LC3-I degradation.

Proc Natl Acad Sci U S A 2019 Jul 18;116(27):13404-13413. Epub 2019 Jun 18.

State Key Laboratory of Cognitive Neuroscience & Learning and Ministry of Education Key Laboratory of Cell Proliferation & Regulation Biology, College of Life Sciences, Beijing Normal University, 100875 Beijing, China;

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http://dx.doi.org/10.1073/pnas.1901039116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613085PMC
July 2019

Ubiquitin Ligases in Cancer Immunotherapy - Balancing Antitumor and Autoimmunity.

Trends Mol Med 2019 May 18;25(5):428-443. Epub 2019 Mar 18.

National Cancer Institute (NCI) Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2019.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488401PMC
May 2019

The mTORC1/4E-BP/eIF4E Axis Promotes Antibody Class Switching in B Lymphocytes.

J Immunol 2019 01 10;202(2):579-590. Epub 2018 Dec 10.

Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697;

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http://dx.doi.org/10.4049/jimmunol.1800602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324996PMC
January 2019

Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survival.

EMBO J 2018 10 12;37(20). Epub 2018 Sep 12.

Tumor Initiation and Maintenance Program, Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA

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http://dx.doi.org/10.15252/embj.201899735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187221PMC
October 2018

Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis.

Cell Rep 2018 09;24(12):3296-3311.e6

Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA; Technion Integrated Cancer Center, Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, 31096, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.08.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185744PMC
September 2018

CALPA-IN NF1.

Oncotarget 2018 Sep 4;9(69):33051. Epub 2018 Sep 4.

Ze'ev A. Ronai: Technion Integrated Cancer Center, Technion, Haifa, Israel; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.18632/oncotarget.25990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145707PMC
September 2018

BRN 2 Invade.

Cancer Cell 2018 07;34(1):1-3

Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA; Technion Integrated Cancer Center, Technion, Haifa, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311383PMC
July 2018

Ubiquitin ligases in oncogenic transformation and cancer therapy.

Nat Rev Cancer 2018 02 15;18(2):69-88. Epub 2017 Dec 15.

Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92130, USA.

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http://dx.doi.org/10.1038/nrc.2017.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054770PMC
February 2018

Rewired Notch/p53 by Numb'ing Mdm2.

J Cell Biol 2018 02 16;217(2):445-446. Epub 2018 Jan 16.

Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA

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http://dx.doi.org/10.1083/jcb.201712007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800819PMC
February 2018

SHARPIN-mediated regulation of protein arginine methyltransferase 5 controls melanoma growth.

J Clin Invest 2018 01 11;128(1):517-530. Epub 2017 Dec 11.

Tumor Initiation and Maintenance Program, Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.

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http://dx.doi.org/10.1172/JCI95410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749505PMC
January 2018

Precision Oncology: The Road Ahead.

Trends Mol Med 2017 10 5;23(10):874-898. Epub 2017 Sep 5.

Tumor Initiation and Maintenance Program, NCI designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA; Technion Integrated Cancer Center, Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, 31096, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2017.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718207PMC
October 2017

Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons.

Neuron 2017 Jun;94(6):1142-1154.e6

Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Solomon H. Snyder Department of Neuroscience, Department of Molecular Biology and Genetics, Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2017.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553555PMC
June 2017

ATF2, a paradigm of the multifaceted regulation of transcription factors in biology and disease.

Pharmacol Res 2017 05 15;119:347-357. Epub 2017 Feb 15.

Department of Tumor Biology and Program in Chemical Biology and Molecular Medicine, H. Lee Moffitt Cancer Center, Tampa, FL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2017.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457671PMC
May 2017

Monoubiquitination in proteasomal degradation.

Authors:
Ze'ev A Ronai

Proc Natl Acad Sci U S A 2016 08 1;113(32):8894-6. Epub 2016 Aug 1.

Tumor Initiation and Maintenance Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037

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http://dx.doi.org/10.1073/pnas.1610186113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987802PMC
August 2016

Adaptive Stress Responses During Tumor Metastasis and Dormancy.

Trends Cancer 2016 Aug 26;2(8):429-442. Epub 2016 Jul 26.

Tumor Initiation and Maintenance Program, National Cancer Institute (NCI) designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2016.06.004DOI Listing
August 2016

A Transcriptionally Inactive ATF2 Variant Drives Melanomagenesis.

Cell Rep 2016 05 19;15(9):1884-92. Epub 2016 May 19.

Tumor Initiation and Maintenance Program, Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.04.072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889472PMC
May 2016

Regulators of mitochondrial dynamics in cancer.

Curr Opin Cell Biol 2016 Apr 18;39:43-52. Epub 2016 Feb 18.

Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Rd, La Jolla, CA 92037, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ceb.2016.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828329PMC
April 2016

Metabolism in melanoma metastasis.

Pigment Cell Melanoma Res 2016 Mar 18;29(2):118-9. Epub 2015 Dec 18.

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http://dx.doi.org/10.1111/pcmr.12440DOI Listing
March 2016

HIV Drug to Aid Melanoma Therapies?

Cancer Cell 2016 Mar;29(3):245-246

Tumor Initiation and Maintenance Program, Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.02.014DOI Listing
March 2016

Immunogenic, cellular, and angiogenic drivers of tumor dormancy--a melanoma view.

Pigment Cell Melanoma Res 2016 Jan 27;29(1):27-42. Epub 2015 Nov 27.

Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1111/pcmr.12432DOI Listing
January 2016

The transcription factor ATF2 promotes melanoma metastasis by suppressing protein fucosylation.

Sci Signal 2015 Dec 8;8(406):ra124. Epub 2015 Dec 8.

Tumor Initiation and Maintenance Program, Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1126/scisignal.aac6479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818095PMC
December 2015

Dysregulation of ubiquitin ligases in cancer.

Drug Resist Updat 2015 Nov 28;23:1-11. Epub 2015 Sep 28.

Sanford Burnham Prebys Medical Discovery Institute, La Jolla, 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.drup.2015.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4688568PMC
November 2015

Right on TARGET: glutamine metabolism in cancer.

Oncoscience 2015 20;2(8):681-3. Epub 2015 Aug 20.

Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580059PMC
http://dx.doi.org/10.18632/oncoscience.205DOI Listing
October 2015

ATF2 alters melanocyte response and macrophage recruitment in UV-irradiated neonatal mouse skin.

Pigment Cell Melanoma Res 2015 Jul 30;28(4):481-4. Epub 2015 May 30.

Cancer Center, Sanford Burnham Medical Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1111/pcmr.12382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996074PMC
July 2015

Glutamate and asparagine cataplerosis underlie glutamine addiction in melanoma.

Oncotarget 2015 Apr;6(10):7379-89

Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480687PMC
http://dx.doi.org/10.18632/oncotarget.3132DOI Listing
April 2015

The UPs and DOWNs of MITF in melanoma resistance.

Pigment Cell Melanoma Res 2015 Mar 23;28(2):132-3. Epub 2014 Dec 23.

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http://dx.doi.org/10.1111/pcmr.12338DOI Listing
March 2015

UPR, autophagy, and mitochondria crosstalk underlies the ER stress response.

Trends Biochem Sci 2015 Mar 2;40(3):141-8. Epub 2015 Feb 2.

Sanford-Burnham Medical Research Institute, La Jolla, CA, 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2015.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340752PMC
March 2015

Fine tuning of the UPR by the ubiquitin ligases Siah1/2.

PLoS Genet 2014 May 8;10(5):e1004348. Epub 2014 May 8.

Tumor Initiation and Maintenance Program, Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014425PMC
May 2014

Regulators and effectors of Siah ubiquitin ligases.

Cell Biochem Biophys 2013 Sep;67(1):15-24

Signal Transduction Program, Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1007/s12013-013-9636-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758783PMC
September 2013

RACK1 Function in Cell Motility and Protein Synthesis.

Genes Cancer 2013 Sep;4(9-10):369-77

Signal Transduction Program, Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1177/1947601913486348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863339PMC
September 2013

Structure-based design of covalent Siah inhibitors.

Chem Biol 2013 Aug 25;20(8):973-82. Epub 2013 Jul 25.

Signal Transduction Program and Cell Death Program, Cancer Center, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.chembiol.2013.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763817PMC
August 2013

Inhibition of melanoma growth by small molecules that promote the mitochondrial localization of ATF2.

Clin Cancer Res 2013 May 15;19(10):2710-22. Epub 2013 Apr 15.

Signal Transduction Program, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-2689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690798PMC
May 2013

The anaphase-promoting complex or cyclosome supports cell survival in response to endoplasmic reticulum stress.

PLoS One 2012 23;7(4):e35520. Epub 2012 Apr 23.

Signal Transduction Program, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035520PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335095PMC
September 2012

Translational homeostasis via the mRNA cap-binding protein, eIF4E.

Mol Cell 2012 Jun 10;46(6):847-58. Epub 2012 May 10.

Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec H3A 1A3, Canada.

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http://dx.doi.org/10.1016/j.molcel.2012.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085128PMC
June 2012

ATF2 - at the crossroad of nuclear and cytosolic functions.

J Cell Sci 2012 Jun 8;125(Pt 12):2815-24. Epub 2012 Jun 8.

Signal Transduction Program, Sanford-Burnham Medical Research Institute, 10901 N. Torrey Pines Rd, La Jolla, CA 92130, USA.

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http://dx.doi.org/10.1242/jcs.095000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434827PMC
June 2012

Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells.

Pigment Cell Melanoma Res 2012 May 27;25(3):375-83. Epub 2012 Mar 27.

Sanford-Burnham Medical Research Institute, Cancer Research Center, La Jolla, CA, USA.

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http://dx.doi.org/10.1111/j.1755-148X.2012.00989.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329592PMC
May 2012

Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect.

J Biol Chem 2011 Dec 13;286(49):42626-34. Epub 2011 Oct 13.

Cancer Research Center, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1074/jbc.M111.282046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234981PMC
December 2011

USP13 enzyme regulates Siah2 ligase stability and activity via noncatalytic ubiquitin-binding domains.

J Biol Chem 2011 Aug 9;286(31):27333-41. Epub 2011 Jun 9.

Signal Transduction Program, Sanford-Burnham Medical Research Institute, La Jolla, California 92130, USA.

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http://dx.doi.org/10.1074/jbc.M111.218214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149327PMC
August 2011

Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control.

Proc Natl Acad Sci U S A 2011 May 13;108(22):9119-24. Epub 2011 May 13.

Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.1100028108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107271PMC
May 2011

The Siah2-HIF-FoxA2 axis in prostate cancer – new markers and therapeutic opportunities.

Oncotarget 2010 Sep;1(5):379-85

Signal Transduction Program, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964873PMC
http://dx.doi.org/10.18632/oncotarget.171DOI Listing
September 2010

Interplay between Cdh1 and JNK activity during the cell cycle.

Nat Cell Biol 2010 Jul 27;12(7):686-95. Epub 2010 Jun 27.

Signal Transduction Program, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA.

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http://www.nature.com/articles/ncb2071
Publisher Site
http://dx.doi.org/10.1038/ncb2071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2899685PMC
July 2010

JNK-mediated phosphorylation of Cdc25C regulates cell cycle entry and G(2)/M DNA damage checkpoint.

J Biol Chem 2010 May 10;285(19):14217-28. Epub 2010 Mar 10.

Signal Transduction Program, Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1074/jbc.M110.121848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863176PMC
May 2010

Inhibition of Siah2 ubiquitin ligase by vitamin K3 (menadione) attenuates hypoxia and MAPK signaling and blocks melanoma tumorigenesis.

Pigment Cell Melanoma Res 2009 Dec 27;22(6):799-808. Epub 2009 Aug 27.

Signal Transduction Program, Burnham Institute for Medical Research, La Jolla, CA, USA.

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http://dx.doi.org/10.1111/j.1755-148X.2009.00628.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863310PMC
December 2009

Melanoma-initiating cells: a compass needed.

EMBO Rep 2009 Sep 14;10(9):965-72. Epub 2009 Aug 14.

Charles C Gates Regenerative Medicine and Stem Cell Program, Department of Dermatology, University of Colorado Denver, Aurora, Colorado 80045, USA.

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http://dx.doi.org/10.1038/embor.2009.184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750051PMC
September 2009

Control of p53 multimerization by Ubc13 is JNK-regulated.

Proc Natl Acad Sci U S A 2009 Aug 27;106(31):12676-81. Epub 2009 Jul 27.

Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Quebec, H3T 1J4, Canada.

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http://dx.doi.org/10.1073/pnas.0900596106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722327PMC
August 2009

Regulation of TIP60 by ATF2 modulates ATM activation.

J Biol Chem 2008 Jun 8;283(25):17605-14. Epub 2008 Apr 8.

Signal Transduction Program, Burnham Institute for Medical Research, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1074/jbc.M802030200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427333PMC
June 2008

Preclinical studies of celastrol and acetyl isogambogic acid in melanoma.

Clin Cancer Res 2007 Nov;13(22 Pt 1):6769-78

Signal Transduction Program, Cancer Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-07-1536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874065PMC
November 2007