Publications by authors named "Zdzislaw Wawrzak"

59Publications

Cytochrome nitrite reductase from the bacterium represents a new NrfA subclass.

J Biol Chem 2020 08 9;295(33):11455-11465. Epub 2020 Jun 9.

Department of Biochemistry & Molecular Biology, Michigan State University, East Lansing, Michigan, USA

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August 2020

A requirement for an active proton delivery network supports a compound I-mediated C-C bond cleavage in CYP51 catalysis.

J Biol Chem 2020 07 3;295(29):9998-10007. Epub 2020 Jun 3.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

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July 2020

A Remarkable Difference That One Fluorine Atom Confers on the Mechanisms of Inactivation of Human Ornithine Aminotransferase by Two Cyclohexene Analogues of γ-Aminobutyric Acid.

J Am Chem Soc 2020 03 1;142(10):4892-4903. Epub 2020 Mar 1.

Department of Chemistry, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, and Center for Developmental Therapeutics, Northwestern University, Evanston, Illinois 60208, United States.

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March 2020

Validation of Human Sterol 14α-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors.

J Med Chem 2019 11 11;62(22):10391-10401. Epub 2019 Nov 11.

Department of Biochemistry , Vanderbilt University School of Medicine , Nashville , Tennessee 37232 , United States.

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November 2019

Structural and biochemical characterization of 20β-hydroxysteroid dehydrogenase from strain L2-32.

J Biol Chem 2019 08 17;294(32):12040-12053. Epub 2019 Jun 17.

Microbiome Metabolic Engineering Theme, Carl R. Woese Institute for Genomic Biology, Urbana, Illinois 61801

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August 2019

Structural basis of Toxoplasma gondii perforin-like protein 1 membrane interaction and activity during egress.

PLoS Pathog 2018 12 4;14(12):e1007476. Epub 2018 Dec 4.

Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, United States of America.

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December 2018

Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51.

J Biol Chem 2018 12 16;293(50):19344-19353. Epub 2018 Oct 16.

From the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232,

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December 2018

Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis.

ACS Chem Biol 2018 05 19;13(5):1322-1332. Epub 2018 Apr 19.

Center for Structural Genomics of Infectious Diseases (CSGID).

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May 2018

Inherent steroid 17α,20-lyase activity in defunct cytochrome P450 17A enzymes.

J Biol Chem 2018 01 6;293(2):541-556. Epub 2017 Dec 6.

From the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146,

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January 2018

Biochemical and Structural Analyses of Two Cryptic Esterases in Bacteroides intestinalis and their Synergistic Activities with Cognate Xylanases.

J Mol Biol 2017 08 29;429(16):2509-2527. Epub 2017 Jun 29.

Carl R. Woese Institute for Genomic Biology (Microbiome Metabolic Engineering Theme), University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Department of Animal Science, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Energy Biosciences Institute, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. Electronic address:

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August 2017

Crystal structure of nonphosphorylated receiver domain of the stress response regulator RcsB from Escherichia coli.

Protein Sci 2016 12 24;25(12):2216-2224. Epub 2016 Oct 24.

Department of Biochemistry and Molecular Genetics, Center for Structural Genomics of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois, 60611.

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December 2016

Molecular Dissection of Xyloglucan Recognition in a Prominent Human Gut Symbiont.

mBio 2016 Apr 26;7(2):e02134-15. Epub 2016 Apr 26.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA

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April 2016

Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus.

Nat Commun 2016 Mar 18;7:11000. Epub 2016 Mar 18.

Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA.

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March 2016

Structural Basis for Sialoglycan Binding by the Streptococcus sanguinis SrpA Adhesin.

J Biol Chem 2016 Apr 1;291(14):7230-40. Epub 2016 Feb 1.

the Departments of Pharmacology and Biochemistry, Center for Structural Biology, and Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37232,

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April 2016

Structure-Functional Characterization of Cytochrome P450 Sterol 14α-Demethylase (CYP51B) from Aspergillus fumigatus and Molecular Basis for the Development of Antifungal Drugs.

J Biol Chem 2015 Sep 12;290(39):23916-34. Epub 2015 Aug 12.

From the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, the Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37232

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September 2015

X-ray Crystal Structure of Divalent Metal-Activated β-xylosidase, RS223BX.

Appl Biochem Biotechnol 2015 Oct 23;177(3):637-48. Epub 2015 Jul 23.

Synchrotron Research Center, Northwestern University, 9700 S Cass Ave, Argonne, IL, 60439, USA.

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October 2015

Kinetic and structural mechanisms of (5'S)-8,5'-cyclo-2'-deoxyguanosine-induced dna replication stalling.

Biochemistry 2015 Jan 13;54(3):639-51. Epub 2015 Jan 13.

Department of Chemistry and Biochemistry and ‡Science of Advanced Materials Program, Central Michigan University , Mount Pleasant, Michigan 48859, United States.

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January 2015

Type III effector NleH2 from Escherichia coli O157:H7 str. Sakai features an atypical protein kinase domain.

Biochemistry 2014 Apr 10;53(15):2433-5. Epub 2014 Apr 10.

Center for Structural Genomics of Infectious Diseases (CSGID), Molecular Pharmacology and Biological Chemistry, Northwestern University , Chicago, Illinois 60611, United States.

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April 2014

Recognition of O6-benzyl-2'-deoxyguanosine by a perimidinone-derived synthetic nucleoside: a DNA interstrand stacking interaction.

Nucleic Acids Res 2013 Aug 8;41(15):7566-76. Epub 2013 Jun 8.

Department of Chemistry, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Center in Structural Biology, Vanderbilt University, Nashville, TN 37235, USA, Department of Health Sciences and Technology, Institute of Food, Nutrition and Health, ETH Zürich, CH-8092 Zürich, Switzerland, Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA and Department of Health Sciences and Technology, Synchrotron Research Center, Northwestern University, 9700 S Cass Ave, Argonne, IL 60439, USA.

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August 2013

Structure and activity of the NAD(P)+-dependent succinate semialdehyde dehydrogenase YneI from Salmonella typhimurium.

Proteins 2013 Jun 1;81(6):1031-41. Epub 2013 Apr 1.

Department of Chemical Engineering and Applied Chemistry, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada.

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June 2013

Basis of miscoding of the DNA adduct N2,3-ethenoguanine by human Y-family DNA polymerases.

J Biol Chem 2012 Oct 21;287(42):35516-26. Epub 2012 Aug 21.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, USA.

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October 2012

Crystal structures of putative phosphoglycerate kinases from B. anthracis and C. jejuni.

J Struct Funct Genomics 2012 Mar 10;13(1):15-26. Epub 2012 Mar 10.

Department of Molecular Physiology and Biological Physics, University of Virginia, 1340 Jefferson Park Avenue, Charlottesville, VA 22908, USA.

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March 2012

Structural complex of sterol 14α-demethylase (CYP51) with 14α-methylenecyclopropyl-Delta7-24, 25-dihydrolanosterol.

J Lipid Res 2012 Feb 30;53(2):311-20. Epub 2011 Nov 30.

Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA.

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February 2012

Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants.

Acta Crystallogr D Biol Crystallogr 2011 Jun 17;67(Pt 6):524-32. Epub 2011 May 17.

Department of Biochemistry and Molecular Biology, School of Medicine, Wayne State University, 540 East Canfield Avenue, Detroit, MI 48201, USA.

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June 2011

Substrate preferences and catalytic parameters determined by structural characteristics of sterol 14alpha-demethylase (CYP51) from Leishmania infantum.

J Biol Chem 2011 Jul 31;286(30):26838-48. Epub 2011 May 31.

Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA.

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July 2011

Structural insights into inhibition of sterol 14alpha-demethylase in the human pathogen Trypanosoma cruzi.

J Biol Chem 2010 Aug 8;285(33):25582-90. Epub 2010 Jun 8.

Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA.

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August 2010

Structure and DNA binding of alkylation response protein AidB.

Proc Natl Acad Sci U S A 2008 Oct 30;105(40):15299-304. Epub 2008 Sep 30.

Department of Biological Sciences and Center for Structural Biology, Vanderbilt University, Nashville, TN 37232, USA.

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October 2008

Structure of the two-subsite beta-d-xylosidase from Selenomonas ruminantium in complex with 1,3-bis[tris(hydroxymethyl)methylamino]propane.

Arch Biochem Biophys 2008 Jun 14;474(1):157-66. Epub 2008 Mar 14.

Northwestern University Center for Synchrotron Research, Life Sciences Collaborative Access Team, Department of Molecular Pharmacology and Biological Chemistry, 9700 South Cass Avenue, Argonne, IL 60439, USA.

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June 2008

Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles.

Chem Commun (Camb) 2008 Feb 21(7):883-5. Epub 2007 Dec 21.

Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA.

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February 2008

A convergent coordination chemistry-based approach to dissymmetric macrocyclic cofacial porphyrin complexes.

Inorg Chem 2007 Sep 14;46(19):7716-8. Epub 2007 Aug 14.

Department of Chemistry and the International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA.

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September 2007

Supramolecular allosteric cofacial porphyrin complexes.

J Am Chem Soc 2006 Dec;128(50):16286-96

Department of Chemistry and the International Institute for Nanotechnology, Northwestern University, Evanston, Illinois, 60208-3113, USA.

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December 2006

"Wide-open" 1.3 A structure of a multidrug-resistant HIV-1 protease as a drug target.

Structure 2005 Dec;13(12):1887-95

Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.

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December 2005

Crystal structure of a luteoviral RNA pseudoknot and model for a minimal ribosomal frameshifting motif.

Biochemistry 2005 Aug;44(34):11315-22

Department of Biochemistry, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, USA.

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August 2005

Crystallization and preliminary crystallographic analysis of endonuclease VIII in its uncomplexed form.

Acta Crystallogr D Biol Crystallogr 2004 Aug 21;60(Pt 8):1476-80. Epub 2004 Jul 21.

Department of Inorganic Chemistry, The Hebrew University of Jerusalem, 91904, Israel.

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August 2004

Structure of the TDP-epi-vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway.

Proc Natl Acad Sci U S A 2003 Aug 21;100(16):9238-43. Epub 2003 Jul 21.

Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA.

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August 2003

Three-dimensional structure of homodimeric cholesterol esterase-ligand complex at 1.4 A resolution.

Acta Crystallogr D Biol Crystallogr 2003 Jan 19;59(Pt 1):50-6. Epub 2002 Dec 19.

Institute of Bioorganic Chemistry, Russian Academy of Science, Moscow, Russia.

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January 2003

Selenium-assisted nucleic acid crystallography: use of phosphoroselenoates for MAD phasing of a DNA structure.

J Am Chem Soc 2002 Dec;124(50):14910-6

Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA.

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December 2002