Publications by authors named "Zaynab Shakarami"

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Evaluation of the protective and therapeutic effects of gum aqueous extract on cellular and pathological aspects of experimental asthma in Balb/c mice.

Avicenna J Phytomed 2019 May-Jun;9(3):248-259

Faculty of medicine, Baqiyatallah University of medical sciences, Tehran, Iran.

Objective: The purpose of this study was to investigate the protective and therapeutic effects of aqueous extract of gum on an experimental asthma in BALB/c mice.

Materials And Methods: Aqueous extract of dried and milled gum was assemble and evaluate by GC-MS. In order to investigate the effect of gum extract on cellular and pathological aspects of asthma, 60 BALB/c mice were divided into six groups as: negative control, asthmatic group, asthmatic group receiving dexamethasone (1mg/kg; intraperitoneal (IP)) and three asthmatic groups receiving different concentrations of the extract (100, 200 and 400 mg/kg, orally) from the beginning of the study and continued for 84 days. The examined parameters included cell population, IgE antibody production, levels of IL-4, IL-5, TGF-β, INF-γ, IL-10, and IL-17 cytokines, and lung tissue damage.

Results: Regardless of the dose, aqueous extract of gum, caused significant decrease in the number of BALF eosinophilic cells and levels of anti-ovalbumin IgE, IL-4, IL-5 and IL-17 cytokine levels, as well as pathologic damage of the lung tissue. In addition, the amount of anti-inflammatory IL-10, TGF-β, and INF-γ Th1 cytokines significantly increased in the extract-treated groups compared to the asthmatic and dexamethasone-treated groups. Moreover, IFN-γ/IL-4 ratio significantly increased in a dose-dependent manner compared to the un-treated asthma group.

Conclusion: The aqueous extract of gum can be considered as a potent anti-inflammatory and immunomodulatory compound and may be used as a natural compound for treatment of immune system disorders.
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May 2019