Zan Huang

Zan Huang

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Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation.

J Mol Cell Biol 2019 Dec;11(12):1069-1082

State Key Laboratory of Pharmaceutical Biotechnology, Department of Hepatopancreatobiliary Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Nanjing University, Nanjing 210061, China.

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https://academic.oup.com/jmcb/advance-article/doi/10.1093/jm
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http://dx.doi.org/10.1093/jmcb/mjz020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934151PMC
December 2019

KRAB-Zinc Finger Protein ZNF268a Deficiency Attenuates the Virus-Induced Pro-Inflammatory Response by Preventing IKK Complex Assembly.

Cells 2019 12 10;8(12). Epub 2019 Dec 10.

Hubei Key Laboratory of Cell Homeostasis & State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China.

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http://dx.doi.org/10.3390/cells8121604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953056PMC
December 2019

Integrated Omics Reveals Tollip as an Regulator and Therapeutic Target for Hepatic Ischemia-Reperfusion Injury in Mice.

Hepatology 2019 Nov 22;70(5):1750-1769. Epub 2019 Jun 22.

College of Life Sciences, Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, China.

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http://dx.doi.org/10.1002/hep.30705DOI Listing
November 2019

Bone marrow adipose tissue-derived stem cell factor mediates metabolic regulation of hematopoiesis.

Haematologica 2019 Sep 21;104(9):1731-1743. Epub 2019 Feb 21.

Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN, USA

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http://dx.doi.org/10.3324/haematol.2018.205856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717592PMC
September 2019

GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity.

J Mol Cell Biol 2019 Jun;11(6):496-508

State Key Laboratory of Pharmaceutical Biotechnology and Nanjing Drum Tower Hospital, Model Animal Research Center, Nanjing University, Nanjing, China.

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https://academic.oup.com/jmcb/advance-article/doi/10.1093/jm
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http://dx.doi.org/10.1093/jmcb/mjy056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734491PMC
June 2019

Epidermis-Activated Gasdermin-A3 Enhances Thermogenesis of Brown Adipose Tissue through IL-6/Stat3 Signaling.

Am J Pathol 2019 05 19;189(5):1041-1052. Epub 2019 Feb 19.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing Drum Tower Hospital, Model Animal Research Center, Nanjing University, Nanjing, China. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2019.01.012DOI Listing
May 2019

Inhibition of MicroRNA-9-5p Protects Against Cardiac Remodeling Following Myocardial Infarction in Mice.

Hum Gene Ther 2019 03 31;30(3):286-301. Epub 2018 Oct 31.

1 Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital, Soochow University, Suzhou, China.

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http://dx.doi.org/10.1089/hum.2018.059DOI Listing
March 2019

Corrigendum to "Caspase recruitment domain 6 protects against hepatic ischemia/reperfusion injury by suppressing ASK1" [J Hepatol 69 (2018) 1110-1122].

J Hepatol 2019 Mar 4;70(3):578-580. Epub 2019 Jan 4.

Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan 430071, China; Basic Medical School, Wuhan University, Wuhan 430060, China; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China; Institute of Model Animal of Wuhan University, Wuhan 430060, China. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2018.11.001DOI Listing
March 2019

Follistatin-like 1 protects mesenchymal stem cells from hypoxic damage and enhances their therapeutic efficacy in a mouse myocardial infarction model.

Stem Cell Res Ther 2019 01 11;10(1):17. Epub 2019 Jan 11.

Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital, Soochow University, Suzhou, 215006, China.

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http://dx.doi.org/10.1186/s13287-018-1111-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330478PMC
January 2019

Caspase recruitment domain 6 protects against hepatic ischemia/reperfusion injury by suppressing ASK1.

J Hepatol 2018 Nov 27;69(5):1110-1122. Epub 2018 Jun 27.

Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan 430071, China; Basic Medical School, Wuhan University, Wuhan 430060, China; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China; Institute of Model Animals of Wuhan University, Wuhan 430060, China. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2018.06.014DOI Listing
November 2018

Inhibition of PPARγ, adipogenesis and insulin sensitivity by MAGED1.

J Endocrinol 2018 11;239(2):167-180

Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.

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https://joe.bioscientifica.com/view/journals/joe/aop/joe-18-
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http://dx.doi.org/10.1530/JOE-18-0349DOI Listing
November 2018

Antibiotics-induced modulation of large intestinal microbiota altered aromatic amino acid profile and expression of neurotransmitters in the hypothalamus of piglets.

J Neurochem 2018 08 28;146(3):219-234. Epub 2018 Jun 28.

Laboratory of Gastrointestinal Microbiology, Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, National Center for International Research on Animal Gut Nutrition, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu, China.

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http://doi.wiley.com/10.1111/jnc.14333
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http://dx.doi.org/10.1111/jnc.14333DOI Listing
August 2018

ANP32A regulates histone H3 acetylation and promotes leukemogenesis.

Leukemia 2018 07 2;32(7):1587-1597. Epub 2018 Feb 2.

College of Life Sciences, Key Laboratory of Cell Hemostasis of Hubei Province, Wuhan University, Wuhan, Hubei, China.

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http://dx.doi.org/10.1038/s41375-018-0010-7DOI Listing
July 2018

CD4+ T cells memorize obesity and promote weight regain.

Cell Mol Immunol 2018 Jun 19;15(6):630-639. Epub 2017 Jun 19.

State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, 12 Xuefu Road, Pukou District, 210061, Nanjing, China, Jiangsu.

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http://dx.doi.org/10.1038/cmi.2017.36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079001PMC
June 2018

Correction to: Fatty acid oxidation promotes reprogramming by enhancing oxidative phosphorylation and inhibiting protein kinase C.

Stem Cell Res Ther 2018 04 19;9(1):111. Epub 2018 Apr 19.

State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Collaborative Innovation Center of Genetics and Development, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, Nanjing, China.

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http://dx.doi.org/10.1186/s13287-018-0873-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909261PMC
April 2018

Fatty acid oxidation promotes reprogramming by enhancing oxidative phosphorylation and inhibiting protein kinase C.

Stem Cell Res Ther 2018 02 26;9(1):47. Epub 2018 Feb 26.

State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Collaborative Innovation Center of Genetics and Development, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, 12 Xuefu Road, Pukou District, Nanjing, Jiangsu, 210061, China.

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http://dx.doi.org/10.1186/s13287-018-0792-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937047PMC
February 2018

Tetrandrine antagonizes acute megakaryoblastic leukaemia growth by forcing autophagy-mediated differentiation.

Br J Pharmacol 2017 Dec 2;174(23):4308-4328. Epub 2017 Nov 2.

Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China.

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http://dx.doi.org/10.1111/bph.14031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715583PMC
December 2017

ANP32A dysregulation contributes to abnormal megakaryopoiesis in acute megakaryoblastic leukemia.

Blood Cancer J 2017 12 22;7(12):661. Epub 2017 Dec 22.

College of Life Sciences, Hubei Key Laboratory of Cell Homeostasis, Wuhan University, Wuhan, China.

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http://dx.doi.org/10.1038/s41408-017-0031-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802576PMC
December 2017

Insights into innate immune signalling in controlling cardiac remodelling.

Cardiovasc Res 2017 Nov;113(13):1538-1550

Department of Cardiology, Renmin Hospital of Wuhan University, Jiefang Road 238, Wuchang District, Wuhan 430060, People's Republic of China.

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http://dx.doi.org/10.1093/cvr/cvx130DOI Listing
November 2017

Interferon Regulatory Factor 4 Inhibits Neointima Formation by Engaging Krüppel-Like Factor 4 Signaling.

Circulation 2017 Oct 29;136(15):1412-1433. Epub 2017 Aug 29.

From Department of Cardiology, Renmin Hospital of Wuhan University, China (W.-L.C., Z.-G.S., F.-H.G., S.T., X.-Y.Z., Z.-H.W., H.L.); Basic Medical School (W.-L.C., Z.-G.S., J.-J.Q., J.-H.G., F.-H.G., P.Z., C.F., S.T., X.-Y.Z., J.G., Z.-H.W., Z.H., H.L.), Medical Research Institute, School of Medicine (W.-L.C., Z.-G.S., J.-J.Q., J.-H.G., F.-H.G., P.Z., C.F., S.T., X.-Y.Z., J.G., Z.-H.W., Z.H., H.L.), and College of Life Science (J.G., Z.H.), Wuhan University, China; and Institute of Model Animal of Wuhan University, China (W.-L.C., Z.-G.S., J.-J.Q., J.-H.G., F.-H.G., P.Z., C.F., S.T., X.-Y.Z., J.G., Z.-H.W., Z.H., H.L.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.026046DOI Listing
October 2017

Increases in circulating amino acids with in-feed antibiotics correlated with gene expression of intestinal amino acid transporters in piglets.

Amino Acids 2017 09 16;49(9):1587-1599. Epub 2017 Jun 16.

Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, Laboratory of Gastrointestinal Microbiology, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, People's Republic of China.

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http://dx.doi.org/10.1007/s00726-017-2451-0DOI Listing
September 2017

Dusp14 protects against hepatic ischaemia-reperfusion injury via Tak1 suppression.

J Hepatol 2017 Sep 6. Epub 2017 Sep 6.

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China; Basic Medical School, Wuhan University, Wuhan, China; Institute of Model Animals of Wuhan University, Wuhan, China; Medical Research Institute, School of Medicine, Wuhan University, Wuhan, China. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2017.08.032DOI Listing
September 2017

[AKT Is A Therapeutic Target in Myeloproliferative Neoplasms].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2017 Aug;25(4):1105-1112

Department of Pediatrics, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei Province, China. E-mail:

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http://dx.doi.org/10.7534/j.issn.1009-2137.2017.04.026DOI Listing
August 2017

Induction of INKIT by Viral Infection Negatively Regulates Antiviral Responses through Inhibiting Phosphorylation of p65 and IRF3.

Cell Host Microbe 2017 Jul;22(1):86-98.e4

Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, China. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2017.06.013DOI Listing
July 2017

ZNF300 tight self-regulation and functioning through DNA methylation and histone acetylation.

Cell Biosci 2017 28;7:33. Epub 2017 Jun 28.

Department of Neurology, Zhongnan Hospital of Wuhan University, Wuhan, 430072 Hubei People's Republic of China.

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http://dx.doi.org/10.1186/s13578-017-0160-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490171PMC
June 2017

The E3 ligase tripartite motif 8 targets TAK1 to promote insulin resistance and steatohepatitis.

Hepatology 2017 05 22;65(5):1492-1511. Epub 2017 Mar 22.

School of Basic Medical Sciences, Wuhan University, Wuhan, China.

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http://dx.doi.org/10.1002/hep.28971DOI Listing
May 2017

Ablation of Interferon Regulatory Factor 3 Protects Against Atherosclerosis in Apolipoprotein E-Deficient Mice.

Hypertension 2017 03 23;69(3):510-520. Epub 2017 Jan 23.

From the Department of Cardiology, Renmin Hospital of Wuhan University, China (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li); and The Institute of Model Animals (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), Medical Research Institute, School of Medicine (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), Collaborative Innovation Center of Model Animal (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), Cardiovascular Research Institute (H. Liu, W.-L.C., X.J., P.-X.W., C.F., X.-Y.Z., Z.-G.S., H. Li), and College of Life Science (Z.H.), Wuhan University, China.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.116.08395DOI Listing
March 2017

Dickkopf-3 Ablation Attenuates the Development of Atherosclerosis in ApoE-Deficient Mice.

J Am Heart Assoc 2017 02 20;6(2). Epub 2017 Feb 20.

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China

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http://dx.doi.org/10.1161/JAHA.116.004690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523766PMC
February 2017

Loss of Caspase-Activated DNase Protects Against Atherosclerosis in Apolipoprotein E-Deficient Mice.

J Am Heart Assoc 2016 12 22;5(12). Epub 2016 Dec 22.

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China

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http://dx.doi.org/10.1161/JAHA.116.004362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210397PMC
December 2016

Protein phosphatase 2A regulatory subunit B56β modulates erythroid differentiation.

Biochem Biophys Res Commun 2016 09 17;478(3):1179-84. Epub 2016 Aug 17.

Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Soochow University, Suzhou 215006, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.08.090DOI Listing
September 2016

Gastric Bypass Surgery Reverses Diabetic Phenotypes in Bdnf-Deficient Mice.

Am J Pathol 2016 08 11;186(8):2117-2128. Epub 2016 Jul 11.

State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, Nanjing, China; Collaborative Innovation Center of Genetics and Development, Nanjing University, Nanjing, China. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2016.04.009DOI Listing
August 2016

Tumor necrosis factor receptor-associated factor 5 (Traf5) acts as an essential negative regulator of hepatic steatosis.

J Hepatol 2016 07 23;65(1):125-136. Epub 2016 Mar 23.

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China; Animal Experiment Center/Animal Biosafety Level-III Laboratory, Wuhan University, Wuhan 430071, China; Medical Research Institute, School of Medicine, Wuhan University, Wuhan 430071, China. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2016.03.006DOI Listing
July 2016

PP2A regulates kinetochore-microtubule attachment during meiosis I in oocyte.

Cell Cycle 2016 06 20;15(11):1450-61. Epub 2016 Apr 20.

a State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Collaborative Innovation Center of Genetics and Development, Nanjing University , Nanjing , China.

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http://dx.doi.org/10.1080/15384101.2016.1175256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934050PMC
June 2016

The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling.

Nat Commun 2016 06 1;7:11267. Epub 2016 Jun 1.

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.

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http://dx.doi.org/10.1038/ncomms11267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895385PMC
June 2016

Tyrosine 625 plays a key role and cooperates with tyrosine 630 in MPL W515L-induced signaling and myeloproliferative neoplasms.

Cell Biosci 2016 23;6:34. Epub 2016 May 23.

College of Life Sciences, Wuhan University, 16 Luo-Jia-Shan Road, Wuhan, 430072 Hubei People's Republic of China.

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http://dx.doi.org/10.1186/s13578-016-0097-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877759PMC
May 2016

Baicalein antagonizes acute megakaryoblastic leukemia in vitro and in vivo by inducing cell cycle arrest.

Cell Biosci 2016 1;6:20. Epub 2016 Apr 1.

College of Life Sciences, Wuhan University, 16 Luo-Jia-Shan Road, Wuhan, 430072 Hubei People's Republic of China.

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http://dx.doi.org/10.1186/s13578-016-0084-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818455PMC
April 2016

Protein phosphatase 2A plays an important role in migration of bone marrow stroma cells.

Mol Cell Biochem 2016 Jan 26;412(1-2):173-80. Epub 2015 Dec 26.

Institute for Cardiovascular Science & Department of Cardiovascular Surgery of the First Affiliated Hospital, Soochow University, Suzhou, 215006, Jiangsu, China.

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http://dx.doi.org/10.1007/s11010-015-2624-7DOI Listing
January 2016

Loss of conserved Gsdma3 self-regulation causes autophagy and cell death.

Biochem J 2015 Jun;468(2):325-36

*Key Laboratory of Model Animal for Disease Study of Ministry of Education, Model Animal Research Center, Collaborative Innovation Center of Genetics and Development, Nanjing University, Nanjing 210061, China.

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http://www.biochemj.org/content/ppbiochemj/468/2/325.full.pd
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http://www.biochemj.org/content/ppbiochemj/early/2015/05/11/
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http://biochemj.org/lookup/doi/10.1042/BJ20150204
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http://dx.doi.org/10.1042/BJ20150204DOI Listing
June 2015

CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritis.

Nat Commun 2015 May 12;6:7086. Epub 2015 May 12.

Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1038/ncomms8086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429912PMC
May 2015

Liver-specific deletion of Ppp2cα enhances glucose metabolism and insulin sensitivity.

Aging (Albany NY) 2015 Apr;7(4):223-32

Key Laboratory of Model Animal for Disease Study of Ministry of Education, Model Animal Research Center, Nanjing University, Nanjing, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429087PMC
http://dx.doi.org/10.18632/aging.100725DOI Listing
April 2015

Novel function of PITH domain-containing 1 as an activator of internal ribosomal entry site to enhance RUNX1 expression and promote megakaryocyte differentiation.

Cell Mol Life Sci 2015 Feb 19;72(4):821-32. Epub 2014 Aug 19.

College of Life Sciences, Wuhan University, Wuhan, 430072, Hubei, People's Republic of China.

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http://dx.doi.org/10.1007/s00018-014-1704-2DOI Listing
February 2015

The stem cell factor/Kit signalling pathway regulates mitochondrial function and energy expenditure.

Nat Commun 2014 Jul 7;5:4282. Epub 2014 Jul 7.

MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, Jiangsu 210061, China.

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http://dx.doi.org/10.1038/ncomms5282DOI Listing
July 2014

Mutation in the first Ig-like domain of Kit leads to JAK2 activation and myeloproliferation in mice.

Am J Pathol 2014 Jan 7;184(1):122-32. Epub 2013 Nov 7.

MOE Key Lab of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, China. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2013.09.019DOI Listing
January 2014

Novel dynamic elongational flow procedure for reinforcing strong, tough, thermally stable polypropylene/thermoplastic polyurethane blends.

Langmuir 2013 Nov 24;29(44):13509-17. Epub 2013 Oct 24.

National Engineering Research Center of Novel Equipment for Polymer Processing, Key Laboratory of Polymer Processing Engineering of the Ministry of Education, South China University of Technology , Guangzhou 510640, China.

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http://dx.doi.org/10.1021/la4023079DOI Listing
November 2013

Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1.

Cell Mol Life Sci 2013 Oct 12;70(20):3947-58. Epub 2013 May 12.

State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, 430072, Hubei, People's Republic of China.

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http://dx.doi.org/10.1007/s00018-013-1359-4DOI Listing
October 2013

IFN-γ suppresses permissive chromatin remodeling in the regulatory region of the Il4 gene.

Cytokine 2013 Apr 13;62(1):91-5. Epub 2013 Mar 13.

Division of Allergy and Immunology, Department of Medicine, National Jewish Health, Denver, CO 80206, USA.

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http://dx.doi.org/10.1016/j.cyto.2013.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615094PMC
April 2013

C1orf61 acts as a tumor activator in human hepatocellular carcinoma and is associated with tumorigenesis and metastasis.

FASEB J 2013 Jan 25;27(1):163-73. Epub 2012 Sep 25.

College of Life Sciences, Wuhan University, Wuhan, China.

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http://dx.doi.org/10.1096/fj.12-216622DOI Listing
January 2013

The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-κB signaling.

J Biol Chem 2012 Dec 22;287(51):42856-66. Epub 2012 Oct 22.

State Key Laboratory of Virology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430072, China.

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http://dx.doi.org/10.1074/jbc.M112.399923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522282PMC
December 2012

Global gene expression during the human organogenesis: from transcription profiles to function predictions.

Int J Biol Sci 2011 7;7(7):1068-76. Epub 2011 Sep 7.

College of Life Sciences, Wuhan University, Wuhan 430072, P.R. China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174391PMC
http://dx.doi.org/10.7150/ijbs.7.1068DOI Listing
January 2012

FLIP: a novel regulator of macrophage differentiation and granulocyte homeostasis.

Blood 2010 Dec 19;116(23):4968-77. Epub 2010 Aug 19.

Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

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http://dx.doi.org/10.1182/blood-2009-11-252841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012591PMC
December 2010

GATA-2 reinforces megakaryocyte development in the absence of GATA-1.

Mol Cell Biol 2009 Sep 20;29(18):5168-80. Epub 2009 Jul 20.

Division of Hematology & Oncology, Northwestern University, Lurie Research Building 5-113, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1128/MCB.00482-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738300PMC
September 2009

A continuous T-bet expression is required to silence the interleukin-4-producing potential in T helper type 1 cells.

Immunology 2009 Sep;128(1):34-42

Division of Allergy and Immunology, Department of Medicine, National Jewish Health, Denver, CO, USA.

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http://dx.doi.org/10.1111/j.1365-2567.2009.03049.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747137PMC
September 2009

Survivin is not required for the endomitotic cell cycle of megakaryocytes.

Blood 2009 Jul 1;114(1):153-6. Epub 2009 Apr 1.

Division of Hematology/Oncology, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1182/blood-2008-11-190801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2710943PMC
July 2009

Signaling pathways that lead to the silencing of the interleukin-4-producing potential in Th1 cells.

J Interferon Cytokine Res 2009 Jul;29(7):399-406

Division of Allergy and Clinical Immunology, Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA.

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http://dx.doi.org/10.1089/jir.2008.0093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956644PMC
July 2009

Induction of lytic cycle replication of Kaposi's sarcoma-associated herpesvirus by herpes simplex virus type 1: involvement of IL-10 and IL-4.

Cell Microbiol 2008 Mar 27;10(3):713-28. Epub 2007 Nov 27.

Laboratory of Reproductive Medicine, Key Laboratory of Pathogen Biology of Jiangsu Province, and Department of Microbiology and Immunology, Nanjing Medical University, Nanjing 210029, China.

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http://dx.doi.org/10.1111/j.1462-5822.2007.01079.xDOI Listing
March 2008

STAT1 promotes megakaryopoiesis downstream of GATA-1 in mice.

J Clin Invest 2007 Dec;117(12):3890-9

Department of Medicine, Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

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http://content.the-jci.org/articles/view/33010
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http://dx.doi.org/10.1172/JCI33010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096448PMC
December 2007

Global mapping of gene/protein interactions in PubMed abstracts: a framework and an experiment with P53 interactions.

J Biomed Inform 2007 Oct 17;40(5):453-64. Epub 2007 Jan 17.

Artificial Intelligence Lab, Department of Management Information Systems, The University of Arizona, McClelland Hall, Tucson, AZ 85721-0108, USA.

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http://dx.doi.org/10.1016/j.jbi.2007.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2047827PMC
October 2007

A direct comparison of two nonviral gene therapy vectors for somatic integration: in vivo evaluation of the bacteriophage integrase phiC31 and the Sleeping Beauty transposase.

Mol Ther 2005 May;11(5):695-706

Department of Pediatrics, School of Medicine, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.ymthe.2005.01.010DOI Listing
May 2005

Increased maintenance and persistence of transgenes by excision of expression cassettes from plasmid sequences in vivo.

Hum Gene Ther 2005 May;16(5):558-70

Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://www.liebertpub.com/doi/10.1089/hum.2005.16.558
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http://dx.doi.org/10.1089/hum.2005.16.558DOI Listing
May 2005

SHP-1 regulates STAT6 phosphorylation and IL-4-mediated function in a cell type-specific manner.

Cytokine 2005 Feb 1;29(3):118-24. Epub 2004 Dec 1.

The Department of Cell Biology, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S104346660400296
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http://dx.doi.org/10.1016/j.cyto.2004.10.004DOI Listing
February 2005

IFN-gamma suppresses STAT6 phosphorylation by inhibiting its recruitment to the IL-4 receptor.

J Immunol 2005 Feb;174(3):1332-7

Graduate Program in Molecular Biology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA.

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http://dx.doi.org/10.4049/jimmunol.174.3.1332DOI Listing
February 2005

Human herpesvirus 6 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus.

Am J Pathol 2005 Jan;166(1):173-83

Department of Microbiology and Immunology, Nanjing Medical University, Nanjing 210029, P. R. China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1602294PMC
http://dx.doi.org/10.1016/S0002-9440(10)62242-0DOI Listing
January 2005

Incorporation of naive bone marrow derived cells into the vascular architecture of brain tumor.

Microcirculation 2004 Dec;11(8):699-708

Department of Neurosurgery, Stanford University, California, USA.

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http://dx.doi.org/10.1080/10739680490521005DOI Listing
December 2004

Cutting edge: IL-5 primes Th2 cytokine-producing capacity in eosinophils through a STAT5-dependent mechanism.

J Immunol 2004 Sep;173(5):2918-22

Department of Cell Biology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA.

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http://dx.doi.org/10.4049/jimmunol.173.5.2918DOI Listing
September 2004

In vivo activity of nuclease-resistant siRNAs.

RNA 2004 May;10(5):766-71

Department of Surgery, Center for Genetic and Cellular Therapies, Duke University Medical Center, Durham, NC 27710, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1370566PMC
http://dx.doi.org/10.1261/rna.5239604DOI Listing
May 2004

Rapid uncoating of vector genomes is the key to efficient liver transduction with pseudotyped adeno-associated virus vectors.

J Virol 2004 Mar;78(6):3110-22

Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC353747PMC
http://dx.doi.org/10.1128/jvi.78.6.3110-3122.2004DOI Listing
March 2004

IL-4 induces differentiation and expansion of Th2 cytokine-producing eosinophils.

J Immunol 2004 Feb;172(4):2059-66

Department of Cell Biology, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153, USA.

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http://dx.doi.org/10.4049/jimmunol.172.4.2059DOI Listing
February 2004

Helper-Independent Sleeping Beauty transposon-transposase vectors for efficient nonviral gene delivery and persistent gene expression in vivo.

Mol Ther 2003 Oct;8(4):654-65

Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305-5208, USA.

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http://dx.doi.org/10.1016/s1525-0016(03)00216-8DOI Listing
October 2003

Inhibition of hepatitis B virus in mice by RNA interference.

Nat Biotechnol 2003 Jun 12;21(6):639-44. Epub 2003 May 12.

Department of Pediatrics, Stanford University School of Medicine, 300 Pasteur Drive, Room G305, Stanford, California, USA.

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http://dx.doi.org/10.1038/nbt824DOI Listing
June 2003

[High expression of human FIX(hFIX) in transgenic mice directed by goat beta-casein gene promoter].

Yi Chuan Xue Bao 2002 ;29(3):206-11

Shanghai Institute of Medical Genetics, Shanghai Children's Hospital, Shanghai 200040, China.

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August 2002