Publications by authors named "Zai Chang"

32Publications

The lncRNA / locus orchestrates heart development through regulation of precise expression of .

Development 2019 07 4;146(13). Epub 2019 Jul 4.

Tsinghua Center for Life Sciences, School of Medicine, and School of Life Sciences, Tsinghua University, Beijing 100084, China

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http://dx.doi.org/10.1242/dev.176198DOI Listing
July 2019

An autoimmune disease variant of IgG1 modulates B cell activation and differentiation.

Science 2018 11 4;362(6415):700-705. Epub 2018 Oct 4.

Ministry of Education Key Laboratory of Protein Sciences, Center for Life Sciences, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Institute for Immunology, School of Life Sciences, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1126/science.aap9310DOI Listing
November 2018

HER2/EGFR-AKT Signaling Switches TGFβ from Inhibiting Cell Proliferation to Promoting Cell Migration in Breast Cancer.

Cancer Res 2018 11 31;78(21):6073-6085. Epub 2018 Aug 31.

The State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-18-0136DOI Listing
November 2018

Mouse knockout models reveal largely dispensable but context-dependent functions of lncRNAs during development.

J Mol Cell Biol 2018 04;10(2):175-178

Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1093/jmcb/mjy003DOI Listing
April 2018

Adipose angiotensin II type 1 receptor-associated protein ameliorates metabolic disorders via promoting adipose tissue adipogenesis and browning.

Eur J Cell Biol 2017 Sep 17;96(6):567-578. Epub 2017 May 17.

College of Animal Science and Technology, Jiangxi Agricultural University, Zhimin Road 1101, Nanchang 330045, China. Electronic address:

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http://dx.doi.org/10.1016/j.ejcb.2017.05.003DOI Listing
September 2017

Histone H1 defect in escort cells triggers germline tumor in Drosophila ovary.

Dev Biol 2017 04 21;424(1):40-49. Epub 2017 Feb 21.

Gene Regulatory Lab, School of Medicine, Tsinghua University, Beijing 100084, China. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2017.02.012DOI Listing
April 2017

Isoform Switch of TET1 Regulates DNA Demethylation and Mouse Development.

Mol Cell 2016 12 1;64(6):1062-1073. Epub 2016 Dec 1.

Center for Stem Cell Biology and Regenerative Medicine, MOE Key Laboratory of Bioinformatics, THU-PKU Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.10.030DOI Listing
December 2016

Changing Grains for the Prevention and Treatment of Kashin-Beck Disease in Children: a Meta-analysis.

Biomed Environ Sci 2015 Apr;28(4):308-11

College of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.

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http://dx.doi.org/10.3967/bes2015.043DOI Listing
April 2015

Substrate stiffness regulates B-cell activation, proliferation, class switch, and T-cell-independent antibody responses in vivo.

Eur J Immunol 2015 Jun 15;45(6):1621-34. Epub 2015 Apr 15.

MOE Key Laboratory of Protein Science, School of Life Sciences, Tsinghua University, Beijing, China.

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http://doi.wiley.com/10.1002/eji.201444777
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http://dx.doi.org/10.1002/eji.201444777DOI Listing
June 2015

PDK1 orchestrates early NK cell development through induction of E4BP4 expression and maintenance of IL-15 responsiveness.

J Exp Med 2015 Feb 26;212(2):253-65. Epub 2015 Jan 26.

School of Medicine, and Center of Animal Facility, Tsinghua University, Beijing 100086, China

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http://dx.doi.org/10.1084/jem.20141703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322053PMC
February 2015

Performance of the Cas9 nickase system in Drosophila melanogaster.

G3 (Bethesda) 2014 Aug 15;4(10):1955-62. Epub 2014 Aug 15.

Gene Regulatory Lab, School of Medicine, Tsinghua University, Beijing 100084, China

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http://dx.doi.org/10.1534/g3.114.013821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199701PMC
August 2014

Phosphoinositide-dependent kinase 1 and mTORC2 synergistically maintain postnatal heart growth and heart function in mice.

Mol Cell Biol 2014 Jun 24;34(11):1966-75. Epub 2014 Mar 24.

Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, Nanjing, China.

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http://dx.doi.org/10.1128/MCB.00144-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019065PMC
June 2014

Tsc1 deficiency-mediated mTOR hyperactivation in vascular endothelial cells causes angiogenesis defects and embryonic lethality.

Hum Mol Genet 2014 Feb 18;23(3):693-705. Epub 2013 Sep 18.

Department of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

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http://hmg.oxfordjournals.org/content/early/2013/09/18/hmg.d
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/ddt456
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http://dx.doi.org/10.1093/hmg/ddt456DOI Listing
February 2014

Disruption of the Dapper3 gene aggravates ureteral obstruction-mediated renal fibrosis by amplifying Wnt/β-catenin signaling.

J Biol Chem 2013 May 11;288(21):15006-14. Epub 2013 Apr 11.

State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1074/jbc.M113.458448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663521PMC
May 2013

S6K inhibition renders cardiac protection against myocardial infarction through PDK1 phosphorylation of Akt.

Biochem J 2012 Jan;441(1):199-207

MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, China.

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http://dx.doi.org/10.1042/BJ20110033DOI Listing
January 2012

Phosphorylation of the Twist1-family basic helix-loop-helix transcription factors is involved in pathological cardiac remodeling.

PLoS One 2011 Apr 29;6(4):e19251. Epub 2011 Apr 29.

The Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0019251PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084786PMC
April 2011

PDK1 plays a critical role in regulating cardiac function in mice and human.

Chin Med J (Engl) 2010 Sep;123(17):2358-63

Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.

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September 2010

Deletion of Akt1 causes heart defects and abnormal cardiomyocyte proliferation.

Dev Biol 2010 Nov 15;347(2):384-91. Epub 2010 Sep 15.

MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center of Nanjing University, Nanjing, China.

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https://linkinghub.elsevier.com/retrieve/pii/S00121606100104
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http://dx.doi.org/10.1016/j.ydbio.2010.08.033DOI Listing
November 2010

Akt/Protein kinase B is required for lymphatic network formation, remodeling, and valve development.

Am J Pathol 2010 Oct 19;177(4):2124-33. Epub 2010 Aug 19.

Laboratory of Vascular and Cancer Biology, MOE Key Laboratory for Model Animal and Disease Study, Model Animal Research Institute, Nanjing University, Nanjing, China.

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http://dx.doi.org/10.2353/ajpath.2010.091301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947305PMC
October 2010

PKB/Akt signaling in heart development and disease.

Front Biosci (Elite Ed) 2010 Jun 1;2:1485-91. Epub 2010 Jun 1.

MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Centre of Nanjing University, Nanjing, China.

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http://dx.doi.org/10.2741/e207DOI Listing
June 2010

PDK1 regulates vascular remodeling and promotes epithelial-mesenchymal transition in cardiac development.

Mol Cell Biol 2010 Jul 10;30(14):3711-21. Epub 2010 May 10.

Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.00420-10
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http://dx.doi.org/10.1128/MCB.00420-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897563PMC
July 2010

[Human bone marrow stromal cells facilitate the cord blood CD34+ cells ex vivo expansion and short-term engraftment in NOD/SCID mice].

Zhonghua Xue Ye Xue Za Zhi 2008 Feb;29(2):97-100

Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

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February 2008

Antiatherogenic property of triterpenoids-enriched extract from the aerial parts of Salvia miltiorrhiza.

Phytother Res 2008 Aug;22(8):1040-5

Department of Chinese Materia Medica Analysis, China Pharmaceutical University, Nanjing, P. R. China 210038.

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http://dx.doi.org/10.1002/ptr.2426DOI Listing
August 2008

Potential treatment of liver-related disorders with in vitro expanded human liver precursors.

Differentiation 2007 Dec 9;75(10):928-38. Epub 2007 May 9.

Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

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http://dx.doi.org/10.1111/j.1432-0436.2007.00184.xDOI Listing
December 2007

Ursane triterpenoids inhibit atherosclerosis and xanthoma in LDL receptor knockout mice.

Cardiovasc Drugs Ther 2006 Oct;20(5):349-57

Department of Chinese Materia Medica Analysis, China Pharmaceutical University, Nanjing, People's Republic of China.

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http://dx.doi.org/10.1007/s10557-006-0509-4DOI Listing
October 2006

Chemical composition of the volatile oil from Cynanchum stauntonii and its activities of anti-influenza virus.

Colloids Surf B Biointerfaces 2005 Jul;43(3-4):198-202

Key Laboratory of Biomechanics & Tissue Engineering (Chongqing University), Ministry of Education Bioengineering College of Chongqing University, Chongqing 400044, PR China.

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https://linkinghub.elsevier.com/retrieve/pii/S09277765050014
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http://dx.doi.org/10.1016/j.colsurfb.2005.05.003DOI Listing
July 2005

Procyanidins from grape seeds protect against phorbol ester-induced oxidative cellular and genotoxic damage.

Acta Pharmacol Sin 2004 Aug;25(8):1083-9

Department of Pharmacology, Marine Drug Research Center, Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China.

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August 2004