Publications by authors named "Zahra Razzaghi"

21 Publications

  • Page 1 of 1

Evaluation of CXCR1 as a possible diagnostic biomarker in acute appendicitis.

Gastroenterol Hepatol Bed Bench 2020 ;13(Suppl1):S106-S112

Firoozabadi Hospital, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Aim: The present study was conducted to determine the genes with common expression in blood and appendix tissue samples in order to introduce them as possible diagnostic biomarkers.

Background: Diagnosis of acute appendicitis (AA) without applying computed tomographytomography (CT), subjecting the patient to significant radiation, can be surprisingly difficult. Blood circulation may have conscious alterations in its RNA, protein, or metabolite composition.

Methods: The genes related to appendix tissue and blood samples of the patients with AA were extracted from public databases. Fold change (FC) ≥ 2 in blood and FC ≥ 5 in appendix tissue samples were considered to screen differentially expressed genes (DEGs). A protein-protein interaction network was organized using the search tool for retrieval of interacting genes and proteins (STRING) database as a plugin of Cytoscape software version 3.6.0. The main genes were enriched by DAVID Bioinformatics Resources to find the related biochemical pathways.

Results: Among the DEGs in blood and appendix tissue samples, C-X-C motif chemokine receptor 1(CXCR1), leukocyte immunoglobulin-like receptor A3 (LILRA3), low-affinity immunoglobulin gamma Fc region receptor III (FCGR3), and superoxide dismutase 2(SOD2) were common in both sources. CXCR1 was found as only hub gene upregulated in both blood and tissue of the patients with AA compared to controls and those with other abdominal pain.

Conclusion: CXCR1, FCGR3, LILRA3, and SOD2 were determined as a suitable possible biomarker panel for diagnosis of AA disease.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881397PMC
January 2020

Effects of intravenous and transdermal photobiomodulation on the postoperative complications of coronary artery bypass grafting surgery: a randomized, controlled clinical trial.

Lasers Med Sci 2021 Jan 4. Epub 2021 Jan 4.

Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.

Although coronary artery bypass graft (CABG) surgery is one of the most worldwide commonly performed cardiac surgeries to enhance myocardial perfusion in high-grade myocardial occlusion, it remains a high-risk procedure. Photobiomodulation (PBM) is one of the methods which have been shown to have positive effects on the healing process after CABG and postoperative complications. The aim of this study was to evaluate the efficacy of PBM in patients who underwent a coronary artery bypass graft (CABG). Ths study was conducted with 192 volunteers who electively submitted to CABG. The volunteers were randomly allocated into two groups: laser-treated (transdermal: 980 nm, 200 mW, continuous, average energy fluency of 6 J/cm and intravenous: 405 nm, 1.5 mW, continuous for 30 min) and standard treatment and control group (standard treatment only). Intravenous laser was illuminated the day before the surgery, immediately after transferring the patient to CCU post-operation and IV laser in addition to transdermal laser was applied every day after surgery for 6 days. A total of 170 out of 192 participants completed the study, 82 (48.2%) in the PBM group and 88 (51.8%) in the control group. Level of LDH and CPK was significantly lower in the PBM group (P < 0.05) in the 4th day postoperatively. The PBM group also showed significantly lower post-surgery complications, including pericardial effusion, ejection fraction, pathologic ST changes, pathologic Q, rehospitalization, heart failure, and mediastinitis (P < 0.05). Likewise, the VAS pain score after surgery was significantly lower in patients in the laser group (P < 0.05). PBM seems a promising, safe, cost-benefit therapeutic modality to reduce postoperative complications of CABG. Trial registration number: IRCT2016052926069N4 .
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http://dx.doi.org/10.1007/s10103-020-03236-3DOI Listing
January 2021

Immunological reactions by T cell and regulation of crucial genes in treated celiac disease patients.

Gastroenterol Hepatol Bed Bench 2020 ;13(2):155-160

Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Aim: To assess the immunological reactions and gene expression level in the celiac disease (CD) patients under a gluten-free diet (GFD).

Background: CD is an autoimmune disorder in genetic susceptible individuals and lifelong gluten free diet is the effective treatment method. It seems that treated patients will experience a normal life style though there are documents about some potential damages.

Methods: Gene expression profiles of treated CD patients and healthy samples were obtained from Gene Expression Omnibus (GEO) and compared to find the differentially expressed genes (DEGs). The identified DEGs were introduced in the network and gene ontology (GO) analysis.

Results: Ten differentially expressed genes (DEGs) including CCR2, IRF4, FASLG, CCR4, ICOS, TNFSF18, BACH2, LTF, PRM1, and PRM2 were investigated via network analysis. Seven clusters of biological processes (BP) were determined as the affected BP. PThe finding led to introduction of CCR2, IRF4, FASLG, CCR4, and ICOS as the potential immunological markers that are still active despite GFD in the treated CD patients.

Conclusion: The results of this study indicated that the immune system is already active in treated CD patients despite GFD treatment and exposure to gluten causes potential immunological reactions in these patients.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149810PMC
January 2020

Evaluation of the Therapeutic Effect of Low Level Laser in Controlling Low Back Pain: A Randomized Controlled Trial.

J Lasers Med Sci 2020 15;11(2):120-125. Epub 2020 Mar 15.

Physical Medicine and Rehabilitation specialist, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Low back pain (LBP) is a very common musculoskeletal disorder. The big burden of disease necessitates investigating a more effective modality of treatments with more persistence and also fewer side effects. Low power laser has been proved as a pain reducing modality, but there is a lack of studies comparing it with other treatments and also among the Iranian race and society. The purpose of this study was to evaluate the effect of low-level laser on patients with LBP. Our study was a single-blind, randomized controlled trial. Forty subjects, aged between 20 to 70 with LBP participated in the study. Their pain severity scale was 3-10 according to the visual analogue scale of pain (VAS). They were randomly assigned to two groups, a case group (true laser) and a control group (sham laser). Naproxen was prescribed with a free dose (250-1000 mg/ daily) to both groups. We evaluated patients' subjective pain, functional status (using the Roland Morris disability questionnaire), spinal range of motion (ROM) and spinal tenderness at the basic time, one month and 3 months after treatment. The true laser group received 12 sessions of laser (160 mW) and the control group took 12 sessions of sham laser (the same laser instrument in off status). An infrared laser GaAlAs, wavelength 808 nm, power 160 mw and spot size 1 cm2 and power density 0.16 J/cm in continuous mode was used in treatment. We applied the laser to articular spaces of vertebral column, adjacent paravertebral points, pain radiating areas, tender points and also pain-controlling acupuncture points. Of the 40 participants in the study, 6 persons were excluded and thus the data obtained from 34 participants were statistically analyzed. There was significant improvement in pain (<0.001 for both groups), functional status (Case group: <0.001; control group: =0.004) and spinal ROM (Case group: <0.001; control group: =0.007) in both groups at the end of the first month, but these gains persisted for 3 months only in the case group ( <0.001). Regarding spinal tenderness, it was disappeared in 89.47% of the patients in the true laser group at the end of one month but remained unchanged in 73.33% of the subjects of the sham laser group. We concluded that laser therapy (in combination with NSAIDs) is an effective and long-lasting therapeutic strategy in bringing relief from LBP without any significant side effect.
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http://dx.doi.org/10.34172/jlms.2020.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118512PMC
March 2020

Assessment of Dysregulation of HERC6 and Essential Biological Processes in Response to Laser Therapy of Human Arm Skin.

J Lasers Med Sci 2020 15;11(2):115-119. Epub 2020 Mar 15.

Firoozabadi Hospital, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.

The widespread application of lasers in medicine, especially in the treatment of diseases implies more investigations to understand the precious molecular mechanism of the laser effect on the human body. In the present study, the prominent role of HERC6 in response to CO Laser therapy of human skin is investigated. The numbers of 16 gene expression profiles before and after the treatment with the CO laser are downloaded from Gene Expression Omnibus (GEO), and differentially-expressed genes (DEGs) are analyzed to find the significant DEGs. Gene ontology analysis revealed that HERC6 and a set of its neighbors played a significant role in response to laser application. The expression changes of 52 significant DEGs were compared via heat map analysis and 27 significant DEGs were introduced as the critical genes which are involved in response to laser irradiation. "Thymidylate kinase activity" among 9 clusters of biological terms was highlighted as an important biological process related to the identified DEGs. HERC2 was proposed as a critical DEG which was related to several essential cellular processes in response to laser application. The findings from the present study indicate that HERC6 and the numbers of its first neighbors are involved in the essential cellular response to laser therapy of human skin.
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http://dx.doi.org/10.34172/jlms.2020.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118510PMC
March 2020

Effect of the Fractional CO Laser on the Quality of Life, General Health, and Genitourinary Symptoms in Postmenopausal Women With Vaginal Atrophy: A Prospective Cohort.

J Lasers Med Sci 2020 18;11(1):65-69. Epub 2020 Jan 18.

Kamali Hospital, Alborz University of Medical Science, Karaj, Iran.

After menopause women experience vaginal atrophy related to hormonal changes and estrogen deficiency. The purpose of this paper was to evaluate the effect of the fractional CO laser on the quality of life, vaginal atrophy symptoms, and urine incontinency in menopause women. This prospective study was conducted among 140 women from 2017 to 2018 in Yas hospital, Tehran University of Medical Sciences. They encountered the fractional microablative CO2 laser system three times at four-week intervals. The short form of the Health Questionnaire (SF-12) and the Female Sexual Functional Index (FSFI) questionnaire were utilized to assess the participants' quality of life. Also, the standard measuring tools including the vaginal health index (VHI) and International Consultation on Incontinence Questionnaire (ICIQ) Form were used to evaluate the vaginal atrophy symptoms. The quality of life improved significantly in somatic, social function, and mental health. In the sexual context, arousal and satisfaction status improved significantly. Also, the frequency of urinary incontinence, enuresis, urgency, and the leak improved significantly (<0.05). Among the scale variables for urinary function, it was seen that the urgency impact had no improvement. All vaginal indices improved (<0.05). The fractional CO laser can be effective in treating vaginal atrophy and urinary symptoms. Besides, it improved the quality of life and the sexual function of post-menopausal women.
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http://dx.doi.org/10.15171/jlms.2020.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008741PMC
January 2020

Comparison of cytokine and gene activities in tissue and blood samples of patients with celiac disease.

Gastroenterol Hepatol Bed Bench 2019 ;12(Suppl1):S108-S116

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Aim: The aim of this study is to explore the expression of genes associated to celiac disease (CD) in the target tissue and peripheral blood monocytes (PBMC) or serum to introduce possible potential biomarkers.

Background: Celiac disease (CD) is an autoimmune disease induced by gluten ingestion in genetically predisposed individuals. Despite technological progress, small intestine biopsy is still the gold standard for diagnosis of CD.

Methods: CD data were collected from public databases (proteomics and microarray-based techniques documents). Differentially expressed genes (DEGs) in PBMC or serum as well as small intestinal biopsies from celiac patients compared to normal were collected and analyzed to introduce common individuals. Gene ontology was done to identify the involved biological terms.

Results: Among 598 CD genes in biopsies and 260 genes in PBMC or serum, 32 common genes with a similar expression pattern in both sources were identified. A total of 48 biological terms were introduced which were involved in the CD via the determined DEGs. "Cytokine activity" was the most expanded one of the biological terms.

Conclusion: In this analysis, it was concluded that 32 potential biomarkers of CD can be assessed by complementary research to introduce effective and available biomarkers in biopsy and blood.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011060PMC
January 2019

Gallbladder cancer integrated bioinformatics analysis of protein profile data.

Gastroenterol Hepatol Bed Bench 2019 ;12(Suppl1):S66-S73

Proteomics Research Center, faculty of paramedical sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Aim: Identifying the critical genes that differentiate gall bladder cancer from a normal gall bladder and the related biological terms was the aim of this study.

Background: The molecular mechanism underlying gall bladder cancer (GBC) trigger and development still requires investigations. Potential therapeutic biomarkers can be identified through protein-protein interaction network prediction of proteome as a complementary study.

Methods: Here, a literature review of proteomics studies of gall bladder cancer from 2010 to 2019 was undertaken to screen differentially expressed proteins in this cancer. A network of 27 differentially expressed proteins (DEPs) via Cytoscape 3.7.1 and its plug-ins was constructed and analyzed.

Results: Ten proteins were introduced as hub-bottlenecks among which four were from DEPs. The gene ontology analysis also indicated that positive regulation of multi-organism process and regulation of response to biotic stimulus are the most disrupted biological processes of GBC considering their relationships with the DEPs.

Conclusion: ACTG, ALB, GGH, and DYNC1H1, and relative biological terms were introduced as drug targets and possible diagnostic biomarkers.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011054PMC
January 2019

The Impact of Proteomic Investigations on the Development and Improvement of Skin Laser Therapy: A Review Article.

J Lasers Med Sci 2019 1;10(Suppl 1):S90-S95. Epub 2019 Dec 1.

Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Different molecular approaches have contributed to finding various responses of skin to external and internal tensions such as laser irradiation and many important mediators of skin disease have been identified through these approaches. However, different essential signals of skin biomarker pathways and proteins are partially detected or completely unknown. In the present study, the impact of proteomics on the evaluation of laser therapy for the treatment of skin diseases is investigated. The keywords of "Proteomics", "Laser therapy", "Skin", and "Skin disease" were searched in Google Scholar, Scopus and PubMed search engines. After screening, 53 documents were included in the study. The global assessments revealed that different proteins in different signaling pathways of skin metabolism in terms of health or illness after laser therapy are expressed differentially. The results indicated that the application of proteomics is a useful method for promoting the results of laser interventions. This kind of research dealt with the practical proteomics of skin diseases and skin laser therapy.
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http://dx.doi.org/10.15171/jlms.2019.S16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983869PMC
December 2019

The Efficacy of IPL in Periorbital Skin Rejuvenation: An Open-Label Study.

J Lasers Med Sci 2019 1;10(Suppl 1):S64-S67. Epub 2019 Dec 1.

Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Intense pulsed light (IPL) is one of the effective methods used to treat the signs of facial aging. However, its efficacy in improving the appearance of periorbital wrinkles has always been evaluated in the context of whole-face rejuvenation and not studied in its own right. Therefore, in this study, we sought to examine the effectiveness and side effects of IPL in periorbital skin rejuvenation. In this uncontrolled, open-label clinical trial, 38 patients referred to the Behrooz professional skin clinic for signs of periorbital skin aging were recruited. The patients underwent three treatment sessions with IPL at one-month intervals and were evaluated for treatment side effects after each session. Six months after the final IPL session, patients were examined to assess the level of symptom improvement. The patients were photographed at each treatment session and on the 6-month follow-up visit. Before and after treatment, the patient images were evaluated by two dermatologists unaffiliated with the study to determine the extent of improvement in the appearance of wrinkles and skin texture. Six months' post-treatment, excellent improvement was observed in 3 patients (9.1%), considerable improvement in 7 patients (21.2%), moderate improvement in 9 patients (27.3%), mild improvement in 9 patients (27.3%), and finally little or no improvement in 5 patients (15.1%). A comparison of improvement scores based on the Fitzpatrick skin phenotype did not show significant differences (P=0.674). Four patients (12.1%) were dissatisfied with the treatment, whilst 17 patients (51.5%) reported moderate to considerable satisfaction with IPL rejuvenation. During facial rejuvenation, IPL can be used to improve periorbital skin aging.
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http://dx.doi.org/10.15171/jlms.2019.S12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983864PMC
December 2019

Radiation Therapy in Patients With Brain Cancer: Post-proteomics Interpretation.

J Lasers Med Sci 2019 1;10(Suppl 1):S59-S63. Epub 2019 Dec 1.

Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Radiation therapy (RT) as a common method for cancer treatment could result in some side effects. The molecular investigation is one of the approaches that could assist in decrypting the molecular mechanisms of this incident. For this aim, protein-protein interaction (PPI) network analysis as a complementary study of the proteome is conducted to explore the RT effect on brain cancer after the early stage of exposure prior to the appearance of the skin lesion. Cytoscape 3.7.2 and its plug-ins were used to analyze the network of differential expression of proteins (DEPs) in the treatment condition, and the centrality and pathway enrichment was conducted by the use of NetworkAnalyzer and ClueGO+CluePedia. A network of 15 DEPs indicated that 6 nodes were key players in the network stability and SERPINC1 and F5 were from the query proteins. The pathways of post-translational protein phosphorylation, platelet degranulation, and complement and coagulation cascades were the most highlighted ones for the central nodes that could be affected in RT. The central proteins of the network of early-stage treatments could have additional importance in the mechanisms of radiotherapy response prior to skin lesions. Introduced biomarkers can be used for the patients' follow-up. These candidates are worth precise attention for this type of therapy after approving by validation studies.
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http://dx.doi.org/10.15171/jlms.2019.S11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983876PMC
December 2019

Laser Therapy for Peyronie's Disease: A Randomized Control Double-Blind Pilot Study.

J Lasers Med Sci 2019 1;10(Suppl 1):S37-S42. Epub 2019 Dec 1.

Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

The management of Peyronie's disease (PD) has remained a therapeutic dilemma for physicians and there is no gold standard treatment. In this paper, we decided to investigate the beneficial effect of the intralesional administration of verapamil compared with the intralesional administration of verapamil plus a low-intensity laser (LIL). Research was activated from May 2016 to May 2018 and a total of 38 men aged 18 years and older completed the investigation. The subjects were randomly divided into 2 groups. Group 1 was composed of 22 patients that were treated only by verapamil (5 mg) plus a sham laser weekly for 6 weeks, and group 2 consisted of 22 patients that received a laser, using the BTL-6000 HIGH-INTENSITY LASER 12 W machine and the same protocol of intralesional verapamil injection. The visual analogue scale (VAS) was used to evaluate pain during an erection, penile ultrasonography was used to measure plaque size, the penile curvature angle degree was measured using the photographs taken during an erection, and the International Index of Erectile Function questionnaire was used to assess erectile function. The follow-up treatment lasted for nine months, with visits performed in the 3rd and 9th months. All study parameters decreased significantly after treatment in both arms, but the reduction in pain and penile curvature improvements in combination therapy revealed more significant changes in 3 months (p = .035, p=.032). Nevertheless, these improvements were not seen in the follow-up session after 9 months. A laser appears to be safe treatment modality in carefully-selected patients with PD. It has moderate efficacy in the short term.
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http://dx.doi.org/10.15171/jlms.2019.S7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983865PMC
December 2019

Association of macrophage inhibitory factor -173 gene polymorphism with biological behavior of prostate cancer.

Urol J 2019 02 21;16(1):32-36. Epub 2019 Feb 21.

Laser Application in Medical Sciences research center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: Chronic inflammation is an important factor in the etiology of prostate cancer. Macrophage migration inhibitory factor (MIF) plays an important regulatory role in inflammatory responses. The aim of this study was to investigate the potential association between MIF-173 G/C polymorphism, and both biological behavior and incidence of prostate cancer.

Materials And Methods: Analysis of polymorphic variants for MIF was performed using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in 128 subjects with prostate cancer and 135 controls.

Results: The frequency of MIF-173 *C allele was significantly (OR = 2.18, 95% CI = 1.32-3.61) higher in patients with prostate cancer (19.5%) than in healthy individuals (10%). Prostate cancer patients with Gleason scores ? 7 had higher frequency of MIF-173 *C allele than Gleason scores < 7 (86.1% vs. 27.1%, P = 0.003, OR = 3.18, 95%CI = 1.46-6.95). The frequency of MIF-173 *C allele was significantly different in patients with T1, T2 and ?T3 clinical stages of prostate cancer (15.2% vs. 42.6% and 47.8%, P = 0.003).

Conclusion: Our data suggest that MIF-173 polymorphisms may be associated with a higher incidence of prostate cancer compared to controls. We believe that MIF-173 GC+CC genotype can be used as a predictive factor for aggressive behavior of prostate cancer including pathological stage and Gleason scores as well as metastatic potential.
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http://dx.doi.org/10.22037/uj.v0i0.3968DOI Listing
February 2019

Comparison of the effects of 665 nm low level diode Laser Hat versus and a combination of 665 nm and 808nm low level diode Laser Scanner of hair growth in androgenic alopecia.

J Cosmet Laser Ther 2017 May 17. Epub 2017 May 17.

e Department of Epidemiology and Biostatistics , School of Public Health, Tehran University of Medical Sciences , Tehran , Iran .

Background: This study aimed to evaluate the effectiveness of a combined set of low level diode laser scanner (665 nm and 808nm) on hair growth, and assessment of safety and effectiveness of a new laser scanner on hair growth treatment procedure in androgenic alopecia.

Methods: 90 patients (18 to 70 years) with androgenic alopecia were randomized into three groups. The first group (n=30) received 655 nm red light using laser hat, the second group (n=30) received 655 nm red laser plus 808 nm infrared laser using a laser scanner of hair growth device (with the patent number: 77733) and the third group (n=30) received no laser as the control group.

Results: Patients in laser scanner group had better results and showed a higher increase in terminal hair density compared with laser hat group (mean of 9.61 versus 9.16 per cm). We found significant decrease in terminal hair density from baseline in control group (mean -1.8 per cm, p<0.0001).

Conclusion: Results showed a statistically significant improvement in the laser scanner of the hair growth group compared with laser hat and the control group. The study showed that treatment with new laser devise had a promising result without any observable adverse effects.
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http://dx.doi.org/10.1080/14764172.2017.1326609DOI Listing
May 2017

Focused Ultrasound Lipolysis in the Treatment of Abdominal Cellulite: An Open-Label Study.

J Lasers Med Sci 2015 28;6(3):102-5. Epub 2015 Jun 28.

Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Introduction: Despite a growing popularity of noninvasive ultrasonic lipolysis procedure, there is a lack of evidence about the efficacy of this method. This study was performed to evaluate the efficacy of focused ultrasonic lipolysis on abdominal cellulite treatment.

Methods: Twenty-eight consecutive subjects (age: 37.8 ± 8 years) underwent weekly transdermal focused ultrasonic lipolysis (Med Contour, General Project Ltd., Florence, Italy) and vacuum drainage for a maximum of eight sessions. Largest abdominal girth and 2 lines at 4 cm to 7 cm distance above and under it were located as fixed points of measurements. The mean value of the three fixed lines was considered as the abdominal circumference. Subjects were evaluated using measurements of circumference, immediately after and 3 weeks after the final treatment and compared using paired t test.

Results: One hundred ninety-four ultrasonic lipolysis procedures were performed on 28 subjects. A statistically significant (P < .001) average of 1.89 cm (95% CI: 1.63-2.02 cm) decrease of circumference value was observed in each session of ultrasonic lipolysis. The mean pretreatment to posttreatment circumference reduction was 8.21 cm (95% CI: 6.38-10.04, P < .001) that declined to 7 cm (95% CI: 3.2-10.8, P < .001) at the 3-month follow-up visit.

Conclusion: Focused ultrasonic lipolysis appears to be an effective method for reduction of abdominal cellulite, although some amount of circumference reduction reversal may be observed in long term follow-up visit.
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http://dx.doi.org/10.15171/jlms.2015.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599195PMC
October 2015

Anti-mullerian hormon level and polycystic ovarian syndrome diagnosis.

Iran J Reprod Med 2015 Apr;13(4):227-30

Infertility Ward, Mahdieh Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Polycystic ovarian syndrome (PCOS) is a common endocrinopathy that accompanied with long term complications. The early diagnosis of this syndrome can prevent it.

Objective: The aim was to determine the role of anti-mullerian hormon (AMH) in PCOS diagnosis and to find cut off level of it.

Materials And Methods: In this cross sectional study, 117 women between 20-40 years old were participated in two groups: 60 PCOS women (based on Rotterdam criteria consensus) as the case group and 57 normal ovulatory women as the control group. In day 2-4 of cycle, transvaginal sonography was performed and serum hormonal level of AMH, luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol (E2), testosterone, fasting blood sugar (FBS), thyroid stimulating hormone (TSH), and prolactin (PRL) were measured in all of participants. For all of them score of hirsutism (base on Freeman-Galloway scoring) was determined.

Results: There were statistically significant in irregular pattern of menstruation, AMH and FSH level, and presence of hirsutism between two groups. But regarding mean of age, body mass index, plasma level of PRL, TSH, LH, Testosterone, FBS, and E2 differences were not significant. Construction by ROC curve present 3.15 ng/ml as AMH cut off with 70.37% sensitivity and 77.36% specificity in order to PCOS diagnosis.

Conclusion: AMH with cut off level of 3.15 ng/ml with sensitivity 70.37% and specificity 77.36% could use for early diagnosis of PCOS patients.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475772PMC
April 2015

Comparing the Healing Effects of Arnebia euchroma Ointment With Petrolatum on the Ulcers Caused by Fractional CO2 Laser: A Single-Blinded Clinical Trial.

Iran Red Crescent Med J 2014 Oct 5;16(10):e16239. Epub 2014 Oct 5.

Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, IR Iran.

Background: Arnebia euchroma ointment (AEO) has been used in Iranian traditional medicine for burn wound healing.

Objectives: The aim of this study is to evaluate wound healing efficacy of AEO in burn wounds after fractional Co2 laser.

Patients And Methods: This split-face, single-blinded, single-center clinical study was performed in Shohada-e-Tajrish Hospital, Tehran, Iran. A total of 26 subjects with facial acne scar, who were to receive fractional CO2 laser resurfacing were recruited. After laser procedure, AEO was applied to one side of the face and petrolatum on the other side for wound healing. Digital photographs were taken from acne scar area before resurfacing and on each of the assessment sessions. Three researchers, who were unaware of the applied medications, assessed these digital photographs for erythema, edema, epithelial confluence, crusting/scabbing, and general wound appearance. Subject's irritations such as dryness and itching were evaluated on the second, fifth, and seventh days.

Results: Our study indicated higher epithelial confluence and general wound appearance scores (P = 0.045 for both) and less erythema and edema on fifth day in petrolatum (P = 0.009 and P = 0.034, respectively). The results showed less crusting and erythema (P = 0.016 and P = 0.035, respectively) and higher general wound appearance scores in petrolatum on the second day (P = 0.035 and P = 0.001, respectively). Dryness was the most common subjective complaint in both groups; however, it was more severe in AEO, especially on the second day (P = 0.023).

Conclusions: Despite the healing effects of AEO in burn wounds, petrolatum was more effective than AEO in post-laser wound.
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http://dx.doi.org/10.5812/ircmj.16239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270663PMC
October 2014

The frequency of HHV-8 infection in otherwise healthy blood donors as well as renal allograft recipients living in Iran.

Arch Iran Med 2013 Jul;16(7):376-9

London Health Sciences Centre, Western University, London, Ontario, Canada.

Background: Different reports from Middle East countries demonstrated Kaposi's sarcoma (KS) in transplant population. This vascular malignancy occurs mostly among immunocompromised individuals. Human herpesvirus 8 (HHV-8) appears to be the causative factor for the development of this neoplasm. Transplant programs are concerned about the frequencies of HHV-8 infection either in general population or transplant patients.

Methods: The current study was conducted in two phases. Firstly, we detected antibodies against HHV-8 in 790 otherwise healthy blood donors. Secondly, a total of 125 kidney allograft recipients evaluated as being seropositive for HHV-8. We utilized enzyme immunoassay (EIA) for serologic studies.

Results: Among blood donors, the male to female ratio was 1.05 (405 vs. 385 ) while the mean age was 38.9 ± 11.7 years. The serostatus of none of these blood donors were positive for HHV-8. Among kidney recipients, the male to female ratio was 1.9 (82 vs. 43). The mean age was 39.01 ± 14.77 years. Two (1.6%) patients were seropositive for HHV-8.

Conclusion: The prevalence of HHV-8 infection among Iranians is likely to be low. Yet, owing to the evidence of this infection among kidney allograft recipients and its probable role in developing post- transplantation KS (PT-KS), further studies appear to be required to keep the various aspects of this infection under close surveillance.
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http://dx.doi.org/013167/AIM.003DOI Listing
July 2013

Safety and efficacy of pneumatic lithotripters versus holmium laser in management of ureteral calculi: a randomized clinical trial.

Urol J 2013 ;10(1):762-6

Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: To compare efficacy and safety of holmium:YAG laser and pneumatic lithotripter in the management of ureteral stones.

Materials And Methods: One hundred and twelve patients with 1 to 2 cm ureteral calculi were selected for pneumatic or holmium:YAG laser transurethral ureterolithotripsy (56 patients in each group). Ultrasonography and plain abdominal x-ray were performed for all the patients before the operation. The pneumatic lithoclast was Swiss LithoClast, while in laser lithotripsy, holmium:YAG laser frequency was used, which was usually set between 5 and 10 Hz at a power of 10 to 15 Watt. Intravenous urography was performed for all the patients at 3 months to assess functional status and to delineate the ureteral anatomy.

Results: The mean patients' age and stones' size were the same in both groups, and there were no statistical differences. Mean duration of lithotripsy was 13.7 ± 12.6 minutes in laser group and 7.9 ± 4.2 minutes in pneumatic lithotripsy group. Immediate stone-free rate was 100% and 82.1% in the laser and pneumatic groups, respectively (P = .001). Stone pushing back occurred only in 10 (17.9%) patients in pneumatic group. In terms of complications, such as perforation, mucosal injury, and bleeding, there were no differences between the two groups. No intravenous pyelography related complication was seen at 3-month follow-up.

Conclusion: Laser lithotripsy is a superior approach for the management of upper ureteral stones of 1 to 2 cm in size due to its higher rate of stone clearance.
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September 2013

Survival of thyroid cancer and social determinants in Iran, 2001-2005.

Asian Pac J Cancer Prev 2011 ;12(1):95-8

Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Thyroid cancer is the most common endocrine system malignancy in the world, being the 7th most common cancer in females, 14th in males and 11th in both sexes in the Iranian population. The present study aimed to determine survival of thyroid cancers in Iran based on sex, age group, pathology and geographical location.

Methods: The patients selected for this study were 602 out of 5,759 cases listed in the cancer registry system between 2001 and 2005. The Kaplan-Meier method was used for survival estimation and Cox's proportional hazard model for calculating hazard ratios according to demographic and risk variables.

Results: The overall 5-year survival rate was 88.0%. There was a significant difference between survivals of the two sexes. The best and worst survival were in the age groups under 40 and over 60 years old, respectively. The best survival was for papillary type, with the anaplastic type demonstrating the worst survival. The best survival was in the southwest (Khuzestan) and the worst in the northwest (Azarbaijan).

Conclusion: Size of young population and social determinants may be important effective elements for differences in survival, which should be taken more into consideration in managing chronic disease such as thyroid cancer.
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May 2012

Parity and breastfeeding are preventive measures against breast cancer in Iranian women.

Breast Cancer 2011 Jan 10;18(1):51-5. Epub 2010 Mar 10.

Cancer Research Center, Shohada Hospital, Shahid Beheshti University of Medical Sciences, Tajrish, Tehran, Iran.

Background: Breast cancer (BC) is the most prevalent cancer in Iranian women and the fifth most common cause of cancer-related death in Iran. Among predicting factors and preventive measures for BC, the parity and breastfeeding (BF) are controversial issues. We therefore conducted this case-control study to find out the relation of parity and BF to incidence and risk of BC.

Method: A structured questionnaire that covered demographic criteria and BC risk factors was completed for case (376 cases) and control (425 subjects) groups, both matched in terms of demographic variants, reproductive issues, and socioeconomic status. Odds ratio (OR) and 95% confidence intervals (CI) were computed as measures of association from the logistic models. All p values reported are two-sided.

Results: Parity significantly reduces the risk of BC (p < 0.001, OR 2.05, CI 1.4-3.3), and BF is protective (p = 0.0001, OR 0.39, CI 0.27-0.56). The best result was gained with 1-3 parity and 24 months BF and mean duration of 18-24 months per child (p = 0.037, OR 0.7, CI 0.5-0.98).

Conclusion: On the basis of breast anatomical and physiological changes during pregnancy, and parity and breastfeeding, full-term pregnancies and parities with efficient BF significantly reduced the risk of breast cancer compared with nonpregnant and nulliparous women or those who never breastfed. The number of children should ideally be limited to 1-3, and the cumulative duration of BF not less than 25-36 months. We would recommend 1-3 pregnancies and a BF duration not less than 18 months, with best results being achieved with 24 months per child.
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http://dx.doi.org/10.1007/s12282-010-0203-zDOI Listing
January 2011