Publications by authors named "Zahra Nasiri"

20 Publications

  • Page 1 of 1

Clinical manifestation and epidemiological findings of human infection in Iran: systematic review.

J Parasit Dis 2021 Mar 23;45(1):50-58. Epub 2020 Sep 23.

Student Research Committee, Arak University of Medical Sciences, Arak, Iran.

The aim of this study was to collect data and provide information on clinical diagnosis of disease, methods of dissemination, prevention and treatment of human linguatuliasis in order to increase people's awareness and health care. In this study case reports of individuals in Iran those infected with the were taken from the international databases (, Medline (PubMed), Scopus, Iranmedex, Scientific Information Database, and Irandoc) and reviewed. The review covers the case reports of human tongue worm infection published either in Persian or in English between the years 1980-2018. An individual researcher undertook the bibliographic search and evaluation of articles based on inclusion/exclusion of specific criteria. Cases of infection have been reported in eight provinces of Iran. Dietary habits play the important roles in the transmission of the parasite. Clinical diagnosis was achieved by obtaining a patient's history, then completing a clinical examination of the mentioned patients. Symptoms of infection were mainly observed in the upper respiratory tract in most reports, the patient's status was improved by removing the parasite from the infected organ. Given that viscera of slaughtered livestock plays a significant role in the transmission of this infection to humans, Careful inspection of slaughtered livestock in slaughterhouses and Preventing the slaughter of livestock illegally and unsanitary, outside the slaughterhouse, is important. Accordingly, it is very important to train the employees working in the slaughterhouses and the people who consume these organs.
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http://dx.doi.org/10.1007/s12639-020-01276-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921224PMC
March 2021

Interpretation of Hematological, Biochemical, and Immunological Findings of COVID-19 Disease: Biomarkers Associated with Severity and Mortality.

Iran J Allergy Asthma Immunol 2021 Feb 11;20(1):46-66. Epub 2021 Feb 11.

Department of Biostatistics and Social Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.

The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) spread rapidly all over the world in late 2019 and caused critical illness and death in some infected patients. This study aimed at examining several laboratory factors, especially inflammatory and immunological mediators, to identify severity and mortality associated biomarkers. Ninety-three hospitalized patients with confirmed coronavirus disease 2019 (COVID-19) were classified based on disease severity. The levels of biochemical, hematological, immunological, and inflammatory mediators were assessed, and their association with severity and mortality were evaluated. Hospitalized patients were mostly men (77.4%) with an average (standard deviation) age of 59.14 (14.81) years. The mortality rate was significantly higher in critical patients (85.7%). Increased serum levels of blood sugar, urea, creatinine, uric acid, phosphorus, total bilirubin, serum glutamic-oxaloacetic transaminase, serum glutamic-oxaloacetic transaminase, lactic dehydrogenase, C-reactive protein, ferritin, and procalcitonin were significantly prevalent (p=0.002, p<0.001, p<0.001, p=0.014, p=0.047, p=0.003, p<0.001, p<0.001, p<0.001, p<0.001, P<0.001, and p<0.001, respectively) in COVID-19 patients. Decreased red blood cell, hemoglobin, and hematocrit were significantly prevalent among COVID-19 patients than healthy control subjects (p<0.001 for all). Troponin-I, interleukin-6, neutrophil/lymphocyte ratio (NLR), procalcitonin, and D-dimer showed a significant association with the mortality of patients with specificity and sensitivity more than 60%. Age, sex, underlying diseases, blood oxygen pressure, complete blood count along with C-reactive protein, lactic dehydrogenase, procalcitonin, D-dimer, and interleukin-6 evaluation help to predict the severity and required management for COVID-19 patients. Further investigations are highly recommended in a larger cohort study for validation of the present findings.
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http://dx.doi.org/10.18502/ijaai.v20i1.5412DOI Listing
February 2021

6 Hz transcranial alternating current stimulation of mPFC improves sustained attention and modulates alpha phase synchronization and power in dorsal attention network.

Cogn Neurosci 2021 Jan 5;12(1):1-13. Epub 2020 Oct 5.

Department of Psychology, University of Tehran , Tehran, Iran.

Transcranial alternating current stimulation (tACS) is a noninvasive brain stimulation tool appropriate to modulate cortical oscillations and activity via the application of weak currents. The major goal of this study was to investigate the effects of medial Prefrontal Cortex (mPFC) stimulation on sustained attention task performance measured by Rapid Visual Information Processing (RVIP) task and the brain networks assumed to be critical to sustained attention. mPFC has been shown to be involved in sustained attention performance and as a main hub in default mode network (DMN). mPFC activity modulation via theta tACS was implemented in this study. This was a single blind study with 21 participants receiving active and sham stimulation with the electrodes on FPz and the Inion. tACS was able to impact different RVIP measures (total hits, A' (sensitivity to target), total correct rejection, etc.). Relative power spectrum density (PSD) analysis yielded significant increases in theta frequency mostly in the fronto-central regions after active tACS and current source density (CSD) analysis yielded significant power modulations in theta frequency band in post-central gyrus. Furthermore, phase locking value (PLV) analysis showed that there were significant changes in cortical connections in the Dorsal Attention Network (DAN) in alpha frequency band. This study showed that theta frequency tACS over mPFC, was able to produce significant modulations in an RVIP task and its associated brain networks in healthy participants.
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http://dx.doi.org/10.1080/17588928.2020.1817881DOI Listing
January 2021

The effectiveness of mindfulness-based intervention on perceived stress and perception of disease in patients with acute coronary syndrome.

J Educ Health Promot 2020 28;9:130. Epub 2020 May 28.

Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

Context: One of the most important issues in patients with coronary artery disease is their mental health indices such as perceived stress and perception of disease.

Aims: The aim of this study was to evaluate the effectiveness of mindfulness-based intervention on the perceived stress and disease perception of patients with acute coronary syndrome.

Materials And Methods: This is a clinical trial, two-group, and three-stage study on 76 patients with acute coronary syndrome who were randomly divided into intervention and control groups. Nine weekly sessions of mindfulness-based training program were administered to the intervention group. The control group received routine services during this period. Data collection was done before, immediately, and 1 month after the intervention, using the Perceived Stress Scale and the Illness Perception Questionnaire. Data were analyzed using descriptive and inferential statistics.

Results: There was no significant difference between the mean scores of perceived stress and illness perception before intervention. After the intervention and 1 month after it, the mean score of perceived stress in the intervention group was statistically significantly lower than the control group ( < 0.001), and the perception of disease in the intervention group was statistically significantly higher than that of the control group ( < 0.001).

Conclusions: It is worthwhile to suggest the mindfulness-based training program to reduce the perceived stress and correct the perception of disease for patients with acute coronary syndrome.
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http://dx.doi.org/10.4103/jehp.jehp_660_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325788PMC
May 2020

Alpha frequency rTMS modulates theta lagged nonlinear connectivity in dorsal attention network.

Brain Res Bull 2020 09 30;162:271-281. Epub 2020 Jun 30.

Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan.

Dorsolateral prefrontal cortex (DLPFC) is a key structure in dorsal attention network (DAN) that facilitates sustained attention by modulating activity in task related and unrelated regions of the brain. Alpha and theta frequency bands enhance connectivity among different parts of the attention network and these connections are facilitated by long-range nonlinear connectivity in theta and alpha frequency bands. This study is an investigation of the behavioral and electrophysiological effects of alpha and theta frequency repetitive transcranial magnetic stimulation (rTMS) over RDLPFC. 20 healthy participants were randomly assigned to two groups of theta (n = 11, f = 6 Hz) and alpha (n = 9, f = 10 Hz) rTMS. Electroencephalogram (EEG) was recorded before and after each session while resting and performing tasks. Current source density (CSD) and functional connectivity (FC) in DAN and default mode network (DMN) and their correlations with rapid visual information processing task (RVIP) scores were calculated . Alpha frequency rTMS resulted in significant changes in RVIP scores. Active theta rTMS caused an increase in CSD in Postcentral gyrus and active alpha rTMS resulted in significant CSD changes in inferior parietal lobule (IPL). Theta lagged nonlinear connectivity was mudulated by alpha rTMSand FC changes were observed in DAN and DMN. Positive correlations were observed between DAN regions and RVIP scores in the alpha rTMS group. Increased activity in theta frequency band in left aPFC and left DLPFC correlated positively with higher total hits in RVIP. This study showed for the first time that theta and alpha frequency rTMS are able to modulate FC in DAN and DMN in a way that results in better performance in a sustained attention task.
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http://dx.doi.org/10.1016/j.brainresbull.2020.06.018DOI Listing
September 2020

Synergistic Cytotoxic and Apoptotic Effects of Local Probiotic Lactobacillus Brevis Isolated from Regional Dairy Products in Combination with Tamoxifen.

Nutr Cancer 2021 25;73(2):290-299. Epub 2020 May 25.

Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran.

Tamoxifen (TAM), the most widely used anti-estrogenic drug, inhibits the progression of breast cancer through competing with estrogen for binding to the estrogen receptor (ER). Tamoxifen has been the first-line adjuvant endocrine therapy in pre- and postmenopausal patients with ER + breast cancer for two decades. However, due to its side effects, interest in using anticancer agents derived from natural foods has increased. It has recently been stated that some probiotics can improve the efficacy of anticancer drugs via synergistic effects. Here, Local Probiotic Lactobacillus Brevis were isolated and characterized from dairy products and its supernatant was prepared. Proliferation of MCF-7, a breast cancer cell line, was investigated after treatment with Lactobacillus Brevis supernatant (LBS) solely, and in combination with Tamoxifen. In Vitro trials were performed to assess the LBS potency. Bax and Bcl-2 mRNA expression levels and apoptotic effects after these treatments were examined by qRT-PCR and flow cytometry, respectively. The results indicated that LBS induces apoptosis in MCF-7 at high concentrations. Transcription of Bcl-2 was reduced but Bax mRNA expression was enhanced. Tamoxifen's inhibitory effect on the cell growth was synergistically augmented by LBS. In addition, we found that the Bcl-2 mRNA levels in the cells exposed to TAM/LBS were lower than in those treated with TAM alone. Our findings suggest potential role of LB as an adjuvant therapy in cancer treatment and prevention; along with its underlying mechanism.
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http://dx.doi.org/10.1080/01635581.2020.1743871DOI Listing
May 2020

Insights into Nano-Photo-Thermal Therapy of Cancer: The Kinetics of Cell Death and Effect on Cell Cycle.

Anticancer Agents Med Chem 2020 ;20(5):612-621

Medical Physics Department, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.

Background: Despite considerable advances in nano-photo-thermal therapy (NPTT), there have been a few studies reporting in-depth kinetics of cell death triggered by such a new modality of cancer treatment.

Objective: In this study, we aimed to (1) investigate the cell death pathways regulating the apoptotic responses to NPTT; and (2) ascertain the effect of NPTT on cell cycle progression.

Methods: Folate conjugated gold nanoparticle (F-AuNP) was firstly synthesized, characterized and then assessed to determine its potentials in targeted NPTT. The experiments were conducted on KB nasopharyngeal cancer cells overexpressing folate receptors (FRs), as the model, and L929 normal fibroblast cells with a low level of FRs, as the control. Cytotoxicity was evaluated by MTT assay and the cell death mode (i.e., necrosis or apoptosis) was determined through AnnexinV/FITC-propidium iodide staining. Next, the gene expression profiles of some key apoptotic factors involved in the mitochondrial signaling pathway were investigated using RT-qPCR. Finally, cell cycle phase distribution was investigated at different time points post NPTT using flow cytometric analysis.

Results: The obtained results showed that KB cell death following targeted NPTT was greater than that observed for L929 cells. The majority of KB cell death following NPTT was related to apoptosis. RT-qPCR analysis indicated that the elevated expression of Bax along with the depressed expression of Bcl-xL, Survivin and XIAP may involve in the regulation of apoptosis in response to NPTT. Flow cytometric analysis manifested that 16-24 hours after NPTT, the major proportion of KB cells was in the most radiosensitive phases of the cell cycle (G2/M).

Conclusion: This study extended the understanding of the signaling pathway involved in the apoptotic response to NPTT. Moreover, the potential effect of NPTT on sensitizing cancer cells to subsequent radiation therapy was highlighted.
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http://dx.doi.org/10.2174/1871520620666200129111332DOI Listing
February 2021

Alteration in inflammatory mediators in seriously eye-injured war veterans, long-term after sulfur mustard exposure.

Int Immunopharmacol 2020 Mar 1;80:105897. Epub 2019 Nov 1.

Immunoregulation Research Center, Shahed University, Tehran 3319118651, Iran; Department of Immunology, Shahed University, Tehran 3319118651, Iran. Electronic address:

Background: Sulfur mustard (SM) exposure produces extensive systemic and ocular adverse effects on the victims. One of the most important effects is immunological insults that can lead to other organ damages, including the eyes.

Methods: In this descriptive study, 128 SM-exposed veterans with severe eye injury were compared with 31 healthy controls. Tear levels of tumor necrosis factor (TNF)-α and serum concentrations of interleukin (IL)-1α, IL-1β, IL1Ra, IL-6, TNF-α, granulocyte-macrophage colony-stimulating factor (GM-CSF), and Fas Ligand (FasL) were compared between the two groups.

Results: Meibomian gland dysfunction (MGD); tear breakup time (TBUT < 10″); and conjunctival, limbal, and corneal abnormalities were more frequent among the cases (MS-exposed veterans) than the controls. Ocular involvement was mild in 14.8%, moderate in 24.2%, and severe in 60.9% of the cases. Serum levels of IL-1α and FasL were significantly higher among the cases than among the controls (P < 0.001 and P = 0.037, respectively). Also, a significant decrease was observed in serum and tear levels of TNF-α in the cases as compared with controls (P < 0.001, P < 0.001, respectively). Serum levels of FasL were significantly higher in cases with severe ocular involvement than in the controls (P = 0.03). Nonetheless, serum levels of IL-1β, IL-1Ra, IL-1α/IL-1Ra, and IL-6 were not significantly different between the two groups.

Conclusion: Serum levels of IL-1α and FasL may cause different ocular surface abnormalities in SM-exposed patients. Lower tear TNF-α concentration may be due to lower serum levels of this cytokine in these patients.
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http://dx.doi.org/10.1016/j.intimp.2019.105897DOI Listing
March 2020

The Persian version of the Calgary Depression Scale for Schizophrenia (CDSS-P).

Asian J Psychiatr 2019 Oct 30;45:44-49. Epub 2019 Aug 30.

Department of psychiatry, University of Calgary, Calgary, Alberta, Canada.

Determining depression symptoms in schizophrenic patients is a challenging process because of a degree of similarity between depression symptoms and negative symptoms and the extrapyramidal side effects of neuroleptic drugs, but it is crucial to evaluate and measure depression among patients with schizophrenia for a better clinical outcome. The Calgary Depression Scale for Schizophrenia (CDSS) is a valid and reliable instrument used for the evaluation of depression in schizophrenia. This study aimed to determine the psychometric properties of the Persian version of CDSS in a sample of people with schizophrenia. Clinical interviews were conducted with 95 schizophrenic patients (40 inpatients and 55 outpatients), who were assessed with the Positive and Negative Syndrome Scale (PANSS), Hamilton Depression Rating Scale (HDRS-17 and HDRS-24 items), and the Calgary Depression Rating Scale (CDSS). Then an exploratory factor analysis was conducted to determine correlations between scales, Cronbach's alpha, and cutoff scores. The factor analysis led to the extraction of a unifactorial solution. The CDSS had significant relationships with PANSS Negative and PANSS General. However, it had no significant relationship with PANSS Positive and the PANSS Total. The CDSS also had significant relationships with HDRS-17 and HDRS-24. In addition, Cronbach's alpha of total score, test-retest reliability, and cutoff score were estimated at 0.86, 0.82, and 8 (sensitivity = 0.79 and specificity = 0.84), respectively. The findings support the CDSS unifactorial approach. Results also showed that the CDSS Persian version had acceptable psychometric properties; thus, it could be employed to evaluate depression among schizophrenic patients.
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http://dx.doi.org/10.1016/j.ajp.2019.08.017DOI Listing
October 2019

Microbiological Profile of Corneal Ulcers at a Tertiary Referral Center.

Med Hypothesis Discov Innov Ophthalmol 2019 ;8(1):16-21

Ophthalmic Research Center, Department of Ophthalmology, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

The aim of this study was to describe patient demographics, microbiological profile, and antibiotic susceptibility of corneal ulcer at a tertiary referral center to improve and optimize diagnosis and treatment of this potentially blinding entity and to reduce antibiotic misuse. Detailed external and slit-lamp bio-microscopic examination of 123 consecutive patients with suspected corneal ulcer was performed at an ophthalmology clinic. Corneal scraping was carried out under slit-lamp bio-microscopy. The obtained material was inoculated on culture media and smeared on a slide for Gram's staining for morphological identification of bacteria and fungus. For samples that developed colony in culture media, antibiotic susceptibility testing was performed. In a significant percentage of patients (72%) neither bacterial agents nor fungi were the cause of corneal ulcer. Of the 34 culture-proven corneal ulcers, in 79% of the cases, bacteria were detected while in 21% of cases, fungi were found. Of the 27 bacterial corneal ulcers, the majority were (67%) caused by Gram-positive bacteria, of which 50% were , and in the Gram-negative bacterial corneal ulcers, most of the cases (44%) were caused by . In the antibiotic susceptibility report, , and were resistant to Cotrimoxazole (TS), to Erythromycin (E), to Peniciline (PG), to Ceftriaxone (CRO) and Nitrofurantoin (NI), and finally, to Gentamicin (GM). In conclusion, in a significant number of the patients neither bacterial agents nor fungi were offending microorganisms and bacteria were the most common agent of microbiological corneal ulcer, found in 79% of culture-proven corneal ulcers, followed by fungus, found in 21% of culture-proven corneal ulcers.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433196PMC
January 2019

Comparison among Ocular Response Analyzer, Corvis ST and Goldmann applanation tonometry in healthy children.

Int J Ophthalmol 2018 18;11(8):1330-1336. Epub 2018 Aug 18.

Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences; Immunoregulation Research Center, Shahed University, Tehran 141551856, Iran.

Aim: To explore the relationship between different parameters of Ocular Response Analyzer (ORA) and Corvis ST (CST) in a sample of healthy Iranian school-aged children and the relationship between parameters of these 2 instruments against intraocular pressure (IOP), measured by the Goldmann applanation tonometer (GAT-IOP), age and gender, and find possible correlation between ORA and CST with GAT.

Methods: This cross-sectional study included 90 healthy children. A general interview and complete eye examination were performed. Following successful GAT-IOP measurement, ORA and CST were conducted. The CST parameters were A 1/2 length (A1L, A2L), A 1/2 velocity (A1V, A2V), highest concavity deformation amplitude (HCDA), radius of curvature (RoC), peak distance (PD), central corneal thickness (CCT) and IOP. The ORA parameters were corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated IOP (IOP-G) and corneal compensated IOP (IOP-CC). Extracted data was analyzed using the Statistical Package for Social Science software.

Results: Totally 39 males with age of 9.08±1.60 (6-12)y and 51 females with age of 8.96±1.55 (6-13)y were included. Many CST parameters were significantly correlated with CH, CRF, IOP-G and IOP-CC. Some CST parameters had a significant correlation with GAT-IOP, including IOP-CST in both eyes and HCDA, A2L, PD, and RoC in the left eye, but none with age, except A2L in the right eye. The CRF measurement showed a significant correlation with GAT-IOP in both eyes and CH in the right eye, yet, none with age. Among all CST and ORA parameters, CCT-CST in both eyes and A1L in right eye had a significant correlation with gender, although this was a negligible negative correlation. Comparison of mean IOP values by different devices showed a significantly highest IOP overestimation by CST and lowest by IOP-CC compared with GAT. Also, IOP-G versus IOP-CST significantly had the lowest IOP overestimation among others. Overall, either low positive correlation or negligible correlation was found between IOP measurements by 3 instruments.

Conclusion: The study finds the highest IOP overestimation by CST and lowest by IOP-CC compared with GAT. Overall, either low positive correlation or negligible correlation is found between IOP measurements by the 3 instruments.
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http://dx.doi.org/10.18240/ijo.2018.08.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090110PMC
August 2018

Epidemiological Aspects of Visceral Leishmaniasis in Larestan and Ghiro-Karzin Counties, Southwest of Iran.

Osong Public Health Res Perspect 2018 Apr;9(2):81-85

Communicable Disease Unit, Faculty of Health, Shiraz University of Medical Sciences, Shiraz, Iran.

Objectives: parasites are the causative agents of leishmaniasis. The Visceral leishmaniasis (VL) form of the disease is fatal if not treated in most cases. This study examined the epidemiological aspects of VL in two southwest counties of Iran.

Methods: This was a retrospective study of hospitalized patients with a laboratory confirmation of VL from Larestan and Ghiro-Karzin Counties.

Results: For Larestan county, a decline in the incidence of VL has been observed from 2004 to 2015. Significantly more males ( = 14) than females ( = 6) were infected with VL in this county ( < 0.05), >95% of cases in children under 5 years of age. In Ghiro-Karzin county, the results were similar to a decline in VL infection from 2004 to 2015, and slightly more males ( = 14) than females ( = 11). Similarly, the majority of the patients infected with VL were children under 5 years old (88%).

Conclusion: The results from this study indicate that although the incidence of VL infection has reduced over time, VL was more prevalent in boys under 5 years old, suggesting that more attention to controlling the parasite and its vector are required.
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http://dx.doi.org/10.24171/j.phrp.2018.9.2.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935142PMC
April 2018

Epidemiological trend of cutaneous leishmaniasis in two endemic focus of disease, south of Iran.

J Parasit Dis 2016 Dec 14;40(4):1609-1613. Epub 2016 Jan 14.

Health and Surveillance Center, Shiraz University of Medical Sciences, Shiraz, Fars Province Iran.

Cutaneous leishmaniasis is one the most important zoonotic diseases has different invertebrate hosts in different parts of its range, the vectors are often closely related. Leishmaniasis is a world-wide vector borne disease, affecting 88 countries: especially in the Middle East and southwestern Asia. or are confirmed as reservoir and Phlebotomine sand flies are proven as vectors of the disease in the south of Iran. Patients' information collected from Firouzabad and Ghirokarzin county, Fars province in Iran during 2006-2014. Data analyzed by Chi square test using SPSS19 statistic software. 613 cases (61.91 %) lived in rural and 377 (38.08 %) lived in urban areas. All ages were grouped between 1 and ≥30 years. 479 (48.38 %) of patients being male and 511 (51.61 %) female. 39.49 % of patients were with dry lesions and 60.5 % were with wet lesions. Hand ulcers were the highest prevalence part of body (39.59 %). The common frequent size of lesions was lesser than 2 cm. Regarding the most prevalence rate (47.67 %) raised in autumn season. This study showed that cutaneous leishmaniasis was an endemic disease in Firouzabad and Ghirokarzin regions.
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http://dx.doi.org/10.1007/s12639-015-0740-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118366PMC
December 2016

Relationship between Learning Style and Academic Status of Babol Dental Students.

Electron Physician 2016 May 25;8(5):2340-5. Epub 2016 May 25.

DDS, Associate Professor, Department of Pediatric Dentistry, Faculty of Dentistry, Babol University of Medical Sciences, Babol, Iran.

Introduction: Identifying and employing students' learning styles could play an important role in selecting appropriate teaching methods in order to improve education. The aim of this study was to determine the relationship between the students' final exam scores and the learning style preferences of dental students at Babol University of Medical Sciences.

Methods: This cross-sectional study was conducted on 88 dental students studying in their fourth, fifth, and sixth years using the visual-aural-reading/writing-kinesthetic (VARK) learning styles' questionnaire. The data were analyzed with IBM SPSS, version 21, using the chi-squared test and the t-test.

Results: Of the 88 participants who responded to the questionnaire, 87 preferred multimodal learning styles. There was no significant difference between the mean of the final exam scores in students who did and did not prefer the aural learning style (p = 0.86), the reading/writing learning style (p = 0.20), and the kinesthetic learning style (p = 0.32). In addition, there was no significant difference between the scores on the final clinical course among the students who had different preferences for learning style. However, there was a significant difference between the mean of the final exam scores in students with and without visual learning style preference (p = 0.03), with the former having higher mean scores. There was no significant relationship between preferred learning styles and gender (p > 0.05).

Conclusion: The majority of dental students preferred multimodal learning styles, and there was a significant difference between the mean of the final exam scores for students with and without a preference for the visual learning style. In addition, there were no differences in the preferred learning styles between male and female students.
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http://dx.doi.org/10.19082/2345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930252PMC
May 2016

Persian version of frontal assessment battery: Correlations with formal measures of executive functioning and providing normative data for Persian population.

Iran J Neurol 2016 Jan;15(1):16-22

Functional Neurosurgery Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Cognitive impairment in patients with Parkinson's disease (PD) mainly involves executive function (EF). The frontal assessment battery (FAB) is an efficient tool for the assessment of EFs. The aims of this study were to determine the validity and reliability of the psychometric properties of the Persian version of FAB and assess its correlation with formal measures of EFs to provide normative data for the Persian version of FAB in patients with PD.

Methods: The study recruited 149 healthy participants and 49 patients with idiopathic PD. In PD patients, FAB results were compared to their performance on EF tests. Reliability analysis involved test-retest reliability and internal consistency, whereas validity analysis involved convergent validity approach. FAB scores compared in normal controls and in PD patients matched for age, education, and Mini-Mental State Examination (MMSE) score.

Results: In PD patients, FAB scores were significantly decreased compared to normal controls, and correlated with Stroop test and Wisconsin Card Sorting Test (WCST). In healthy subjects, FAB scores varied according to the age, education, and MMSE. In the FAB subtest analysis, the performances of PD patients were worse than the healthy participants on similarities, fluency tasks, and Luria's motor series.

Conclusion: Persian version of FAB could be used as a reliable scale for the assessment of frontal lobe functions in Iranian patients with PD. Furthermore, normative data provided for the Persian version of this test improve the accuracy and confidence in the clinical application of the FAB.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852066PMC
January 2016

Lentiviral vector-mediated transduction of goat undifferentiated spermatogonia.

Anim Reprod Sci 2015 Dec 7;163:10-7. Epub 2015 Sep 7.

Department of Reproductive Biotechnology at Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran; Department of Cellular Biotechnology at Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran. Electronic address:

Recent studies show that spermatogonial stem cells (SSCs) are able to colonize and form mature spermatozoa following transplantation into germ cell depleted testes of recipient males. Therefore, efficient ways for enrichment and gene transfer into SSCs provides a powerful tool for production of transgenic animals. In order to adapt the technique to goats, three issues were addressed: (i) enrichment of the undifferentiated spermatogonia including SSCs using magnetic activated cell sorting (MACS), (ii) lentiviral vector-mediated transduction of an enhanced green fluorescent protein (EGFP) transgene into enriched cells, and (iii) transplantation of transduced undifferentiated spermatogonia into the germ cell depleted testes of immune-suppressed mice to assess for migration and colony formation ability. Enriched cells were transduced by lentiviral vectors and subsequently analyzed for expression of THY1, PLZF, VASA, UCHL1 and BCL6B genes. Cells were also analyzed for GFP and PLZF by flow cytometry. Enriched transduced cells were transplanted into germ cell depleted mice testis. Quantitative analysis of transcripts revealed that MACS-enrichment significantly increased the expression of SSC-characteristic genes THY1, PLZF, VASA, UCHL1 and BCL6B compared to non-enriched population (P≤0.05). EGFP transduction did not affect the expression levels of SSC-characteristic genes. Flow cytometry revealed that 72% of transduced-enriched cells were positive for EGFP. Finally, transduced-enriched goat SSCs could colonize within the cells into the seminiferous tubules of germ cell depleted recipient mice at higher frequency than non-enriched cells. The results indicated that enrichment of goat undifferentiated spermatogonia by magnetic-activated cell sorting for THY1 antibody combined with lentiviral vector-mediated transduction has the potential to be used for production of transgenic goats.
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http://dx.doi.org/10.1016/j.anireprosci.2015.09.002DOI Listing
December 2015

Imaging-based diagnosis of wernicke encephalopathy: a case report.

Trauma Mon 2014 Nov 10;19(4):e17403. Epub 2014 Sep 10.

Department of Neurology, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.

Introduction: Wernicke encephalopathy (WE) is a medical emergency characterized by ataxia, confusion, nystagmus and ophthalmoplegia resulting from thiamin deficiency. Alcoholism is the common cause for this disease.

Case Presentation: A 41 year old man was brought to our emergency department (ED) complaining of confusion. One week earlier he had started to experience severe nausea and vomiting followed by diplopia, dysarthria and also dysphagia. One day later he had experienced gait disturbance and progressive ataxia accompanied with confusion, apathy and disorientation. He had no history of alcoholism, drug abuse or previous surgery but had history of untreated Crohn disease. Just before arrival to our emergency department, he had been hospitalized in another center for about a week but all investigations had failed to provide a conclusive diagnosis. Upon admission to our ED, he was dysarthric and replied with inappropriate answers. On physical examination, bilateral horizontal nystagmus in lateral gaze, left abducens nerve palsy and upward gaze palsy were seen. Gag reflex was absent and plantar reflexes were upwards bilaterally. After reviewing all the previously performed management measures, MRI was performed and was consistent with the diagnosis of WE. Treatment with thiamine led to partial resolution of his upward gaze palsy and nystagmus on the first day. At the end of the third day of treatment, except for gate ataxia, all other symptoms completely resolved and he was fully conscious. After the fifth day his gait became normal and after one week he was discharged in good general condition.

Discussion: After reviewing the current literature, it seems that brain MRI can be helpful in the diagnosis of WE in patients with the classic clinical trial in the absence of clear risk factors.
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http://dx.doi.org/10.5812/traumamon.17403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310158PMC
November 2014

THY1 as a reliable marker for enrichment of undifferentiated spermatogonia in the goat.

Theriogenology 2013 Nov 27;80(8):923-32. Epub 2013 Aug 27.

Department of Animal Science, Faculty of Agriculture, Ferdowsi University of Mashhad, Iran; Department of Reproductive Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.

Spermatogonial stem cells are unique cells of testes that can restore fertility upon transplantation into recipient testes. However, use of suitable markers for enrichment of these cells have important potential application. THY1, is an established conserved marker of spermatogonial stem cells in bovine, rodents, and primates, but there is no information available in goats. After three rounds of enzymatic digestion of prepubertal goat testicular tissues, undifferentiated spermatogonia positive for THY1 were isolated by magnetic-activated cell sorting and were used for immunocytochemistry, real-time polymerase chain reaction analysis for gene expression, protein expression, and transplantation into recipient mice. Immunocytochemical analyses showed that significantly higher percentage of THY1(+) cells were positive for PLZF and VASA when compared with unselected population. This result for PLZF was further confirmed at the protein level. Real-time polymerase chain reaction analysis revealed that expression of THY1, PLZF, VASA, BCL6B, and UCHL1 as SCCs characteristic genes in THY1(+) cells was significantly higher than in the initial population. Finally, transplantation of PKH26-labeled cells revealed that THY1(+) cells had higher capacity for colony formation when compared with unselected cells. In conclusion, the results provide indications that THY1 surface marker can be reliably used for enrichment of undifferentiated spermatogonial in the goats.
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http://dx.doi.org/10.1016/j.theriogenology.2013.07.020DOI Listing
November 2013

The value of reporting decreased or absent fetal movements by mothers in predicting the pregnancy outcome.

Iran J Med Sci 2011 Sep;36(3):235-6

Departments of Obstetrics and Gynecology, Shahed University of Medical Science, Tehran, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556760PMC
September 2011

Can vaginal pH predict menopause?

Saudi Med J 2010 Mar;31(3):253-6

Department of Obstetrics and Gynecology, Amir University Hospital, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.

Objective: To review the role of vaginal pH in the diagnosis of menopause.

Methods: This descriptive cross-sectional study was performed in the Department of Obstetrics and Gynecology, Amir University Hospital, Semnan, Iran from March 2008 to March 2009 on 200 women (100 non-menopausal and 100 post-menopausal) from 45-65 years old. The pH paper was placed directly in contact in the lower third side wall of the vagina, and the pH was measured. Simultaneous sampling and culture of the vaginal discharge and blood samples for follicle stimulating hormone (FSH) was performed in the same day. Cases of bacterial vaginosis, trichomonas or other vaginitis were treated, and again 2 weeks later, the vaginal pH was measured. The gold standard for the diagnosis of menopause was FSH > or =35IU, hypoestrogenemia symptoms, and amenorrhea for one year. Receiver operating characteristic curve was used to determine the best cut-off point. The sensitivity, specificity, positive and negative predictive values were evaluated.

Results: The mean +/- standard deviation age in the post-menopausal women was 58 +/- 3.8, and in non-menopausal women was 47.6 +/- 2. The vaginal pH in the diagnosis of menopause has a sensitivity of 92.7%, specificity - 83.5%, positivity - 84.9%, and negative - 92% predictive values (cut-off point > or =6).

Conclusion: Our study suggests that the pH of the vagina can be a good alternative to test for the diagnosis of menopause.
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March 2010