Dr. Zahiruddin Othman, MD, MMed (Psych) - School of Medical Sciences, USM - Dr

Dr. Zahiruddin Othman

MD, MMed (Psych)

School of Medical Sciences, USM

Dr

Kota Bharu, Kelantan | Malaysia

Main Specialties: Psychiatry

Additional Specialties: Psychiatry

Dr. Zahiruddin Othman, MD, MMed (Psych) - School of Medical Sciences, USM - Dr

Dr. Zahiruddin Othman

MD, MMed (Psych)
Introduction

Primary Affiliation: School of Medical Sciences, USM - Kota Bharu, Kelantan , Malaysia

Specialties:

Additional Specialties:

Metrics

28

Publications

850

Profile Views

67

Reads

52

PubMed Central Citations

Publications

28Publications

67Reads

52PubMed Central Citations

Insight into potential mechanisms of hypobaric hypoxia-induced learning and memory deficit - Lessons from rat studies.

Hum Exp Toxicol 2017 Dec 23;36(12):1315-1325. Epub 2017 Jan 23.

1 Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.

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December 2017
1 Read
1.41 Impact Factor

Internet Addiction and Personality: Association with Impulsive Sensation Seeking and Neuroticism-Anxiety Traits

Int Med J. 2017;24(5):375-378

Introduction: The internet has revolutionized the information age. There has been growing concern regarding internet addiction, despite its benefits. Personality trait such as neuroticism has been linked with internet addiction. Objective: The aim of the present study was to determine the prevalence of internet addiction and its association with personality traits among college students. Methods: College students age 18-24 who were doing an attachment in a government hospital were recruited into the study. Internet addiction was assessed using the internet addiction test (IAT), whilst personality traits by using the cross cultural Malay language 40-item Zuckerman-Kuhlman personality questionnaire (ZKPQ-M-40-CC) Results: The prevalence of internet addiction was 31.8%, with moderate and severe use of internet at 30.7% and 1.1%, respectively. Based on multiple logistic regression analysis, the impulsive sensation seeking and neuroticism-anxiety traits were found to be significantly associated with internet addiction. Conclusions: The prevalence of internet addiction is comparable to other studies conducted in Malaysia. Personality traits impulsive sensation seeking and neuroticism-anxiety emerged as significant associated factors with internet addiction. Further study to understand the role of personality traits in the development of internet addiction is recommended.

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October 2017
2 Reads

Lipopolysaccharide-induced memory impairment in rats: a model of Alzheimer's disease.

Physiol Res 2017 Sep 12;66(4):553-565. Epub 2017 Apr 12.

Department of Physiology and Department of Psychiatry, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.

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September 2017
1 Read
1 PubMed Central Citation(source)
1.49 Impact Factor

Validation of Malay Beck Cognitive Insight Scale

Int Med J. 2017;24(4):314-316

Background: Although the dominant current viewpoint of insight is related to clinical insight, cognitive insight has been gaining popularity since the introduction of Beck Cognitive Insight Scale (BCIS) in 2004. Therefore, an easy and reliable assessment tool of cognitive insight is needed to complement the assessment of clinical insight to improve the psychiatric services and outcomes. Objectives: This study aimed to validate the Malay Beck Cognitive Insight Scale (BCIS-M). Methods: The BCIS was translated into Malay language with good face and content validity. It was administered to 75 patients with schizophrenia in psychiatric outpatient clinic, Hospital Universiti Sains Malaysia (HUSM) in April 2014. Results: The BCIS-M showed good psychometric property. The internal consistency (Cronbach alpha) for self-certainty and self-reflectiveness in this study were 0.609 and 0.699, respectively. Conclusion: The BCIS-M is a valid and reliable tool for assessment of cognitive insight in local Malaysian population.

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August 2017
3 Reads

The Potential Role of Melatonin on Memory Function: Lessons from Rodent Studies.

Folia Biol (Praha) 2016 ;62(5):181-187

Department of Psychiatry, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

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February 2017
1 PubMed Central Citation(source)
0.78 Impact Factor

Attendance at Counselling Sessions Predicts Good Treatment Response in Methadone Maintenance Therapy

Int Med J. 2017;24(1):21-23

Objective: This study aimed to identify the predictors of good response in Methadone Maintenance Therapy (MMT) defined as retention and negative urine for opiate for 6 month after the enrollment. Methods: Across-sectional study from October 2007 to March 2008 was conducted on injecting drug users (IDUs) in the MMT programme at the Psychiatric Clinic, Hospital Raja Perempuan Zainab II (HRPZ II). Results: A total of 150 patients were studied. Good treatment response in MMT was seen in 55% of these patients. The only predictor of good treatment response in multivariate analyses was number of counseling sessions. For every increase in counseling sessions, a person has 1.2 times the chance of having a good outcome (Cl 1.049-1.349, p-value 0.007). Educational level, occupation, marital status, age and maintenance dose were not significantly associated with response in MMT Conclusion: Frequent attendance at counseling sessions was found to have a positive influence in the good treatment response in methadone therapy. Hence, it is an important component in the treatment of patients in MMT programme.

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February 2017
3 Reads

Insight in Offenders with Schizophrenia: Relationship to Psychopathology and Cognitive Function

Int Med J. 2017;24(1):18-20

Objectives: To study the insight in offenders with schizophrenia and its relationship of psychopathology and cognitive function. Methods: Seventy consecutive offenders with schizophrenia (aged 18-65) admitted to Hospital Bahagia Ulu Kinta within a six-month period were studied. Subjects' insight, psychopathology and cognitive function were assessed using the Insight and Treatment Attitude Questionnaire (ITAQ), Positive and Negative Syndrome Scale (PANSS), and Mini Mental State Examination (MMSE) respectively. Results: High PANSS positive scores were significantly associated with unsoundness of mind (p = 0.011). Low ITAQ and MMSE scores were significantly associated with PANSS total, negative and general scores. Conclusion: Positive symptoms were significantly associated with unsoundness of mind. Poor insight and cognitive function were significantly associated with negative symptoms as well as general and global psychopathology. This study however, failed to find significant insight-unsoundness of mind or insight-cognitive function relationships.

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February 2017
1 Read

Tualang Honey Attenuates Noise Stress-Induced Memory Deficits in Aged Rats.

Oxid Med Cell Longev 2016 28;2016:1549158. Epub 2016 Mar 28.

Department of Psychiatry, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150 Kota Bharu, Kelantan, Malaysia.

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December 2016
6 Reads
2 PubMed Central Citations(source)

Use of Queatiapine in Treatment of Unremitting Anxiety: A Case Report of Schizophrenia Prodrome

Int Med J. 2016;23(6):624-625

Objective: A 21-year-old man who presented with a 17-month history of unremitting anxiety associated with panic attacks was studied. Result: The anxiety with panic attacks did not abate with escitalopram 15 mg nocte and alprazolam 0.5 mg tds. At month 3, the patient reported low mood and unexplained sexual arousal in addition to the unremitting anxiety symptoms. His condition fairly improved with addition of quetiapine. At month 17, transition to psychotic disorder occurred when the patient experienced hallucinations for the first time. Quetiapine was increased to 500 mg nocte and the anxiety symptoms improved tremendously before he relapsed 6 months later due to poor compliance. Conclusion: Unremitting anxiety with depression can be a dominant feature during the schizophrenia prodrome. Atypical antipsychotic quetiapine is an interesting treatment option due to its status as approved adjunctive treatment for major depressive disorder and promising efficacy for generalized anxiety disorder.

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December 2016
3 Reads

Self-Esteem among Malay Children of Parents with Schizophrenia in Kelantan, Malaysia.

Int Med J. 2016;23(5):472-475

Background: Studies have demonstrated that children of parents with schizophrenia have low self-esteem. However, only scant data exist for the local population. Objectives: The objective of this study was to evaluate self-esteem of Malay children of parents with schizophrenia and to determine the associated socio-demographic and clinical factors. Methods: A total of 118 children of parents with schizophrenia who attended Hospital Universiti Sains Malaysia (HUSM) between May-September 2012 participated in the study. The children's self-esteem was measured using the Malay version of Rosenberg self-esteem scale (RSES). Patient's psychopathology and level of functioning were measured using the positive and negative syndrome scale (PANSS) and global assessment of functioning (GAF), respectively. Results: The RSES mean score was 23.86 ± 5.31 and low self-esteem (RSES score < 20) was reported by 32.2% subjects. In multivariate analysis, the independent factors associated with low self-esteem were girls (OR 6.29), poor academic achievement (OR 5.49), school attendance/ stopped schooling (OR 9.43), awareness of parental mental illness (OR 5.12) and parent was divorced/widow/separated (OR 3.56). Psychopathology and level of functioning of parents were not significantly associated with self-esteem of the children. Conclusion: Malay children, particularly girls, of parents with schizophrenia had low self-esteem. Children with school problems and whose parents divorced/separated also had low self-esteem.

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October 2016
1 Read

Stigma in Malay Patients with HIV/AIDS in Malaysia

Int Med J. 2016;23(4):324-327

Background: Previous study noted severe impairment of social well-being, compared to other area of QoL in HIV patients, suggesting the role of moral and religious values concerning HIV infection. Objectives: The objective of this study was to evaluate the level and correlates of HIV-related stigma experienced by the patients. Methods: A total of 100 consenting Malay Muslim HIV patients attending the infectious disease out-patient clinic, Hospital Raja Perempuan Zainab II from July 2012 to February 2013 were recruited for study. Results: (1) Stigma among HIV patients attending out-patient clinic was high, particularly disclosure concerns; (2) Female HIV patients had significantly higher disclosure concerns compared to male HIV patients; (3) Among the studied variables, only disclosure was independently associated with total stigma. Conclusion: HIV-related stigma was high and significantly correlated with disclosure of HIV status among Malay Muslim HIV patients. Further studies are warranted to determine additional factors, such as culture and religiosity, which may influence the stigma.

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August 2016
1 Read

Protective Effects of Tualang Honey against Oxidative Stress and Anxiety-Like Behaviour in Stressed Ovariectomized Rats.

Int Sch Res Notices 2014 9;2014:521065. Epub 2014 Sep 9.

Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Malaysia.

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July 2016
1 Read
2 PubMed Central Citations(source)

Validation of Malay Gender Role Conflict Scale for Adolescents

Int Med J. 2016;23(3):219-221

Background: Living in a multiracial country undergoing rapid modernization with strong influence of Western media, exposed the Malaysian adolescents to conflicting gender role messages leading to potential gender role conflict. Objectives: This study aimed to validate the Malay Gender Role Conflict Scale for Adolescents (GRCS-AM). Methods: The GRCS-A was translated into Malay language and administered to 91 secondary school students in Kubang Kerian in July 2012. Results: The internal consistency coefficients of each subscale and the total scale were good with restricted affection between men 0.58; restricted emotionality 0.65; conflict between work, school, and family 0.64; need for success and achievement 0.62; and total scale 0.76. Conclusion: The GRCS-AM is a valid and reliable tool for assessment of gender role conflict in Malaysian adolescent population.

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June 2016
2 Reads

Equivalence and practice effect of alternate forms for Malay version of Auditory Verbal Learning Test (MAVLT).

EXCLI J 2015 7;14:801-8. Epub 2015 Jul 7.

Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Malaysia.

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November 2015
0.86 Impact Factor

Screening for schizophrenia in initial prodromal phase: Detecting the sub-threshold psychosis.

Asian J Psychiatr 2015 Aug 30;16:26-31. Epub 2015 Jun 30.

Department of Psychiatry, Universiti Sains Malaysia, Kota Bharu, 15590, Kelantan, Malaysia.

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August 2015
2 Reads
2 PubMed Central Citations(source)

Tualang honey improves memory performance and decreases depressive-like behavior in rats exposed to loud noise stress.

Noise Health 2015 Mar-Apr;17(75):83-9

Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Malaysia.

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May 2015
6 Reads
4 PubMed Central Citations(source)
1.43 Impact Factor

Enhancement of BDNF concentration and restoration of the hypothalamic-pituitary-adrenal axis accompany reduced depressive-like behaviour in stressed ovariectomised rats treated with either Tualang honey or estrogen.

ScientificWorldJournal 2014 16;2014:310821. Epub 2014 Jan 16.

Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.

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December 2014
4 Reads
7 PubMed Central Citations(source)
1.22 Impact Factor

Psychosis induced by cefuroxime and metronidazole.

Med J Malaysia 2014 Feb;69(1):33-4

Universiti Sains Malaysia, Psychiatry, School of Medical Sciences, Kampus Kesihatan USM, Kubang Kerian, Kelantan 16150, Malaysia.

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February 2014
5 Reads

Tualang honey supplement improves memory performance and hippocampal morphology in stressed ovariectomized rats.

Acta Histochem 2014 Jan 26;116(1):79-88. Epub 2013 Jun 26.

Department of Neuroscience, School of Medical Sciences, Universiti Sains Malaysia Health Campus, 16150 Kubang Kerian, Malaysia.

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January 2014
17 Reads
10 PubMed Central Citations(source)
1.71 Impact Factor

Mood and memory function in ovariectomised rats exposed to social instability stress.

Biomed Res Int 2013 13;2013:493643. Epub 2013 Jun 13.

Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.

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December 2013
5 Reads
3 PubMed Central Citations(source)

Association of oxidative stress and memory performance in postmenopausal women receiving estrogen-progestin therapy.

Menopause 2013 Jun;20(6):661-6

Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

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June 2013
2 Reads
1 PubMed Central Citation(source)
3.36 Impact Factor

Agomelatine in depressive disorders: its novel mechanisms of action.

J Neuropsychiatry Clin Neurosci 2012 ;24(3):290-308

Sri Sathya Sai Medical Educational and Research Foundation, Prasanthi Nilayam, Kovai Thirunagar Coimmbatore-641014, Tamilnadu, India.

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March 2013
1 Read
8 PubMed Central Citations(source)
2.82 Impact Factor

Preliminary study: effects of social instability stress on depressive behaviours in ovariectomised rats.

Malays J Med Sci 2013 Mar;20(2):35-40

Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan.

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March 2013
5 Reads

Melatonergic drugs for therapeutic use in insomnia and sleep disturbances of mood disorders.

CNS Neurol Disord Drug Targets 2012 Mar;11(2):180-9

Sri Sathya Sai Medical Educational and Research Foundation, Prasanthi Nilayam, 40-Kovai Thirunagar, Coimbatore-641014, Tamilnadu, India.

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March 2012
5 Reads
1 PubMed Central Citation(source)
2.63 Impact Factor

Improvement in immediate memory after 16 weeks of tualang honey (Agro Mas) supplement in healthy postmenopausal women.

Menopause 2011 Nov;18(11):1219-24

Department of Psychiatry, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

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November 2011
10 PubMed Central Citations(source)
3.36 Impact Factor

Love tragedy, she wrote.

Malays J Med Sci 2004 Jan;11(1):86-9

Department of Psychological Medicine, Universiti Malaya.

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January 2004
3 Reads

Validation of the Quality of Life Scale (QLS) Malay Version among Patients with Schizophrenia

Int Med J. 2017;24(1):24-26

Objectives: The Quality Of Life Scale (QLS) is an English version of semi-structured interview that assesses quality of life (QOL) among patients with schizophrenia. The aim of this study was to translate and validate the QLS into Malay version for more widespread use in clinical practice. Methods: This study was conducted on 30 schizophrenia patients attending Hospital Raja Perempuan Zainab II (HRPZ II) and Hospital Universiti Sains Malaysia (HUSM). The QLS was translated into Malay language using forward and backward translation method. The final Malay version of the QLS was tested for the content validity by two experienced psychiatrists. Its face validity was tested on 10 Malay patients with schizophrenia. The internal consistency analysis was performed by measuring Cronbach's alpha in all four domains of QLS Results: The Malay version QLS was found to have good content and face validity. It also displayed good internal consistency with Cronbach's alpha of between 0.87 and 0.93. Conclusion: The Malay version QLS is a good tool to be used in future research to assess quality of life of patients with schizophrenia.

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3 Reads