Zahid H Siddik

Zahid H Siddik

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Zahid H Siddik

Zahid H Siddik

Publications by authors named "Zahid H Siddik"

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37Publications

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Platinum(IV)-Ferrocene Conjugates and Their Cyclodextrin Host-Guest Complexes.

Inorg Chem 2019 Jun 24;58(12):7886-7894. Epub 2019 May 24.

Department of Chemistry , The University of Texas at Austin , 100 E. 24th Street , Austin , Texas 78712 , United States.

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http://dx.doi.org/10.1021/acs.inorgchem.9b00570DOI Listing
June 2019

PTGER3 induces ovary tumorigenesis and confers resistance to cisplatin therapy through up-regulation Ras-MAPK/Erk-ETS1-ELK1/CFTR1 axis.

EBioMedicine 2019 Feb 14;40:290-304. Epub 2019 Jan 14.

Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.11.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411965PMC
February 2019

Overview of the oncogenic signaling pathways in colorectal cancer: Mechanistic insights.

Semin Cancer Biol 2019 Jan 8. Epub 2019 Jan 8.

Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S1044579X183009
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http://dx.doi.org/10.1016/j.semcancer.2019.01.001DOI Listing
January 2019

Curcumin-Free Turmeric Exhibits Activity against Human HCT-116 Colon Tumor Xenograft: Comparison with Curcumin and Whole Turmeric.

Front Pharmacol 2017 12;8:871. Epub 2017 Dec 12.

Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston TX, United States.

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http://dx.doi.org/10.3389/fphar.2017.00871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732987PMC
December 2017

Functional Activation of Mutant p53 by Platinum Analogues in Cisplatin-Resistant Cells Is Dependent on Phosphorylation.

Mol Cancer Res 2017 03 28;15(3):328-339. Epub 2016 Dec 28.

Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1541-7786.MCR-16-0257-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334359PMC
March 2017

Drug-dependent functionalization of wild-type and mutant p53 in cisplatin-resistant human ovarian tumor cells.

Oncotarget 2017 Feb;8(7):10905-10918

Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.18632/oncotarget.14228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355233PMC
February 2017

Activation of Platinum(IV) Prodrugs By Motexafin Gadolinium as a Redox Mediator.

Angew Chem Int Ed Engl 2016 10 5;55(41):12626-31. Epub 2016 Jul 5.

Department of Chemistry and Biochemistry, University of Texas at Austin, 105 E. 24th St. Stop A5300, Austin, TX, 78712-1224, USA.

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http://dx.doi.org/10.1002/anie.201604236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039070PMC
October 2016

Platelet-derived growth factor (PDGF) signalling in cancer: rapidly emerging signalling landscape.

Cell Biochem Funct 2015 Jul 7;33(5):257-65. Epub 2015 Jul 7.

University of Texas, MD Anderson Cancer Center, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1002/cbf.3120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289298PMC
July 2015

Copper transporter CTR1 expression and tissue platinum concentration in non-small cell lung cancer.

Lung Cancer 2014 Jul 22;85(1):88-93. Epub 2014 Apr 22.

Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1016/j.lungcan.2014.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090351PMC
July 2014

Photoinduced reduction of Pt(IV) within an anti-proliferative Pt(IV)-texaphyrin conjugate.

Chemistry 2014 Jul 24;20(29):8942-7. Epub 2014 Jun 24.

Department of Chemistry and Institute for Cellular and Molecular Biology, The University of Texas at Austin, 105 E. 24th Street- Stop A5300, Austin, Texas 78712-1224 (USA).

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http://dx.doi.org/10.1002/chem.201403094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241752PMC
July 2014

Recent developments in texaphyrin chemistry and drug discovery.

Inorg Chem 2013 Nov 4;52(21):12184-92. Epub 2013 Apr 4.

Department of Chemistry and Biochemistry, University of Texas , 1 University Station, A5300, Austin, Texas 78712-0165, United States.

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http://dx.doi.org/10.1021/ic400226gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963820PMC
November 2013

Tissue platinum concentration and tumor response in non-small-cell lung cancer.

J Clin Oncol 2012 Sep 13;30(27):3345-52. Epub 2012 Aug 13.

The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 463, Houston, TX 77030, USA.

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http://dx.doi.org/10.1200/JCO.2011.40.8120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438232PMC
September 2012

Resistance and gain-of-resistance phenotypes in cancers harboring wild-type p53.

Biochem Pharmacol 2012 Apr 26;83(8):1049-62. Epub 2011 Dec 26.

Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, 77030, United States.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299825/
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http://linkinghub.elsevier.com/retrieve/pii/S000629521100942
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http://dx.doi.org/10.1016/j.bcp.2011.12.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299825PMC
April 2012

A texaphyrin-oxaliplatin conjugate that overcomes both pharmacologic and molecular mechanisms of cisplatin resistance in cancer cells.

Medchemcomm 2012 ;3(10):1275-1281

Department of Chemistry and Biochemistry, Texas Institute for Diagnostics and Drug Development, The University of Texas, 1 University Station-A5300, Austin, TX 78712-0165, USA. ; Tel: +1 512 471 5009 ; Department of Experimental Therapeutics, UT M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 353, Houston, TX 77030, USA. Fax: +1 713 792 1204; Tel: +1 713 792 7746.

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http://xlink.rsc.org/?DOI=c2md20206a
Publisher Site
http://dx.doi.org/10.1039/C2MD20206ADOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737007PMC
January 2012

The role of p27(Kip1) in dasatinib-enhanced paclitaxel cytotoxicity in human ovarian cancer cells.

J Natl Cancer Inst 2011 Sep 2;103(18):1403-22. Epub 2011 Aug 2.

Department of Experimental Therapeutics, the University of Texas M. D. Anderson Cancer Center, Unit 354, Rm Y6.5343, 1515 Holcombe Blvd, Houston, TX, USA.

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http://dx.doi.org/10.1093/jnci/djr280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176777PMC
September 2011

The impact of S- and G2-checkpoint response on the fidelity of G1-arrest by cisplatin and its comparison to a non-cross-resistant platinum(IV) analog.

Gynecol Oncol 2011 Aug 18;122(2):402-9. Epub 2011 May 18.

Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.ygyno.2011.04.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601787PMC
August 2011

Overcoming biochemical pharmacologic mechanisms of platinum resistance with a texaphyrin-platinum conjugate.

Bioorg Med Chem Lett 2011 Mar 26;21(6):1701-5. Epub 2011 Jan 26.

Department of Chemistry and Biochemistry, Texas Institute for Diagnostics and Drug Development, The University of Texas, Austin, TX 78712-0165, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X110011
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http://dx.doi.org/10.1016/j.bmcl.2011.01.092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463136PMC
March 2011

Bismuth- and lead-texaphyrin complexes: towards potential α-core emitters for radiotherapy.

Chem Commun (Camb) 2010 Nov 4;46(42):7900-2. Epub 2010 Oct 4.

Department of Chemistry & Biochemistry and Institute for Cellular and Molecular Biology, The University of Texas at Austin, 1-University Station A5300, Austin, Texas 78712-0156, USA.

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http://xlink.rsc.org/?DOI=c0cc03528a
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http://dx.doi.org/10.1039/c0cc03528aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197826PMC
November 2010

Protein kinase inhibitors emodin and dichloro-ribofuranosylbenzimidazole modulate the cellular accumulation and cytotoxicity of cisplatin in a schedule-dependent manner.

Cancer Chemother Pharmacol 2010 Feb 16;65(3):427-36. Epub 2009 Jun 16.

Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 353, Houston, TX 77030, USA.

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http://dx.doi.org/10.1007/s00280-009-1045-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045215PMC
February 2010

Gadolinium texaphyrin (Gd-Tex)-malonato-platinum conjugates: synthesis and comparison with carboplatin in normal and Pt-resistant cell lines.

Dalton Trans 2009 Dec 7(48):10834-40. Epub 2009 Oct 7.

Department of Chemistry and Biochemistry, Texas Institute for Diagnostics and Drug Development, 1 University Station-A5300, The University of Texas, Austin, TX 78712-0165, USA.

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http://dx.doi.org/10.1039/b912089kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862451PMC
December 2009

Epidermal growth factor receptor (EGFR) ubiquitination as a mechanism of acquired resistance escaping treatment by the anti-EGFR monoclonal antibody cetuximab.

Cancer Res 2007 Sep;67(17):8240-7

Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-0589DOI Listing
September 2007

Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities.

Oncogene 2005 Apr;24(18):2929-43

Department of Experimental Therapeutics, The University of Texas, MD Anderson Cancer Center, Box 019, 1515 Holcombe Blvd, Houston, TX 77030, USA.

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http://dx.doi.org/10.1038/sj.onc.1208474DOI Listing
April 2005

Model platinum nucleobase and nucleoside complexes and antitumor activity: X-ray crystal structure of [PtIV(trans-1R,2R-diaminocyclohexane)trans-(acetate)2(9-ethylguanine)Cl]NO3.H2O.

J Inorg Biochem 2005 Mar;99(3):795-804

Department of Experimental Therapeutics, P.O. Box 353, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.jinorgbio.2004.12.015DOI Listing
March 2005

Increased sensitivity of a metastatic model of prostate cancer to a novel tetravalent platinum analog.

Prostate 2005 Jan;62(1):91-100

Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1002/pros.20114DOI Listing
January 2005

Role of human copper transporter Ctr1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cells.

Mol Cancer Ther 2004 Dec;3(12):1543-9

Department of Molecular Pathology, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.

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December 2004

Status of p53 phosphorylation and function in sensitive and resistant human cancer models exposed to platinum-based DNA damaging agents.

J Cancer Res Clin Oncol 2003 Dec 26;129(12):709-18. Epub 2003 Sep 26.

Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Box 104, Houston, TX 77030, USA.

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http://dx.doi.org/10.1007/s00432-003-0480-4DOI Listing
December 2003

Cisplatin: mode of cytotoxic action and molecular basis of resistance.

Authors:
Zahid H Siddik

Oncogene 2003 Oct;22(47):7265-79

Department of Experimental Therapeutics, Unit 104, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030-4009, USA.

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http://dx.doi.org/10.1038/sj.onc.1206933DOI Listing
October 2003

Biochemical and molecular mechanisms of cisplatin resistance.

Authors:
Zahid H Siddik

Cancer Treat Res 2002 ;112:263-84

Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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May 2003

Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells.

J Biol Chem 2003 May 12;278(21):19245-56. Epub 2003 Mar 12.

Department of Molecular Therapeutics, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030,USA.

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http://dx.doi.org/10.1074/jbc.M208134200DOI Listing
May 2003

Preparation, characterization, and antitumor activity of new cisplatin analogues with 1-methyl-4-(methylamino)piperidine: crystal structure of [PtII(1-methyl-4-(methylamino) piperidine)(oxalate)].

J Inorg Biochem 2003 Feb;94(1-2):179-85

Department of Experimental Therapeutics, Box 353, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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February 2003