Publications by authors named "Zafar Nawaz"

63Publications

Outcome associated with EPCAM founder mutation c.499dup in Qatar.

Eur J Med Genet 2020 Oct 28;63(10):104023. Epub 2020 Jul 28.

Diagnostic Genomic Division, Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, 3050, Qatar.

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http://dx.doi.org/10.1016/j.ejmg.2020.104023DOI Listing
October 2020

Acute Myeloid Leukemia in Qatar (2010-2016): Clinical, Biological, and Prognostic Factors and Treatment Outcomes.

Front Genet 2020 17;11:553. Epub 2020 Jun 17.

Center of Excellence in Bionanoscience Research and Genomics and Biotechnology Section and Research Group, Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

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http://dx.doi.org/10.3389/fgene.2020.00553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313235PMC
June 2020

A Rare Case of Systemic Mastocytosis with Associated Hematologic Neoplasm (SM-AHN) Involving Chronic Myeloid Leukemia: A Case Report and Literature Review.

Am J Case Rep 2020 May 13;21:e923354. Epub 2020 May 13.

Department of Medical Oncology, Hematology Section, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.

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http://dx.doi.org/10.12659/AJCR.923354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252834PMC
May 2020

Haploinsufficiency of the FOXA2 associated with a complex clinical phenotype.

Mol Genet Genomic Med 2020 06 11;8(6):e1086. Epub 2020 Apr 11.

Division of Endocrinology, Department of Pediatric Medicine, Sidra Medicine, Doha, Qatar.

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http://dx.doi.org/10.1002/mgg3.1086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284027PMC
June 2020

Novel and recurrent germline mutations in the VHL gene in 5 Arab patients with Von Hippel-Lindau disease.

Cancer Genet 2020 05 6;243:1-6. Epub 2020 Mar 6.

Genomics, Ontario Institute for Cancer Research, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cancergen.2020.02.006DOI Listing
May 2020

Plasma Cell Myeloma with an Aggressive Clinical Course and Anaplastic Morphology in a 22-Year-Old Patient: A Case Report and Review of Literature.

Am J Case Rep 2020 Mar 10;21:e920489. Epub 2020 Mar 10.

Department of Medical Oncology, National Center for Cancer Care and Research (NCCCR), Hamad Medical Corporation, Doha, Qatar.

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http://dx.doi.org/10.12659/AJCR.920489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081950PMC
March 2020

An uncommon case of chronic myeloid leukemia with variant cytogenetic.

Acta Biomed 2018 04 3;89(3-S):28-32. Epub 2018 Apr 3.

Department of Medical Oncology, Hematology Section, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.

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http://dx.doi.org/10.23750/abm.v89i3-S.7217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179100PMC
April 2018

Loss of Angelman Syndrome Protein E6AP Disrupts a Novel Antagonistic Estrogen-Retinoic Acid Transcriptional Crosstalk in Neurons.

Mol Neurobiol 2018 Sep 31;55(9):7187-7200. Epub 2018 Jan 31.

Department of Biochemistry and Molecular Biology, Braman Family Breast Cancer Institute at Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Gautier Building, Room 314 (R629), 1011 NW 15th Street, Miami, FL, 33136, USA.

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http://dx.doi.org/10.1007/s12035-018-0871-9DOI Listing
September 2018

Ubiquitination of nuclear receptors.

Clin Sci (Lond) 2017 May;131(10):917-934

Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, U.S.A.

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http://dx.doi.org/10.1042/CS20160708DOI Listing
May 2017

The Molecular Genetics of Autosomal Recessive Nonsyndromic Intellectual Disability: a Mutational Continuum and Future Recommendations.

Ann Hum Genet 2016 Nov;80(6):342-368

Genomic Core Facility, Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, 3050, Qatar.

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http://dx.doi.org/10.1111/ahg.12176DOI Listing
November 2016

High diagnostic yield of clinical exome sequencing in Middle Eastern patients with Mendelian disorders.

Hum Genet 2015 Sep 16;134(9):967-80. Epub 2015 Jun 16.

Clinical and Metabolic Genetics, Department of Pediatrics, Hamad Medical Corporation, P.O.BOX. 3050, Doha, Qatar.

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http://dx.doi.org/10.1007/s00439-015-1575-0DOI Listing
September 2015

Nonsense mutation in the WDR73 gene is associated with Galloway-Mowat syndrome.

J Med Genet 2015 Jun 14;52(6):381-90. Epub 2015 Apr 14.

Department of Cell & Systems Biology, University of Toronto, Toronto, Ontario, Canada Centre for the Analysis of Genome Evolution and Function, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1136/jmedgenet-2014-102707DOI Listing
June 2015

Loss-of-Function Mutation in APC2 Causes Sotos Syndrome Features.

Cell Rep 2015 Mar 5;10(9):1585-1598. Epub 2015 Mar 5.

Division of Molecular Neurobiology, National Institute for Basic Biology, Okazaki 444-8787, Japan; School of Life Science, The Graduate University for Advanced Studies (SOKENDAI), Okazaki 444-8787, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.02.011DOI Listing
March 2015

E6AP in the brain: one protein, dual function, multiple diseases.

Mol Neurobiol 2014 Apr 5;49(2):827-39. Epub 2013 Oct 5.

Department of Biochemistry and Molecular Biology, University of Miami, Miller School of Medicine, 1501 N.W. 10th Avenue, Miami, FL, 33136, USA.

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http://dx.doi.org/10.1007/s12035-013-8563-yDOI Listing
April 2014

Molecular mechanism of WW-domain binding protein-2 coactivation function in estrogen receptor signaling.

IUBMB Life 2013 Jan 10;65(1):76-84. Epub 2012 Dec 10.

Braman Family Breast Cancer Institute / Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.1002/iub.1105DOI Listing
January 2013

ERα phosphorylation at Y537 by Src triggers E6-AP-ERα binding, ERα ubiquitylation, promoter occupancy, and target gene expression.

Mol Endocrinol 2012 Sep 3;26(9):1567-77. Epub 2012 Aug 3.

Braman Family Breast Cancer Institute at Sylvester, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.

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http://dx.doi.org/10.1210/me.2012-1140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434528PMC
September 2012

Biophysical basis of the binding of WWOX tumor suppressor to WBP1 and WBP2 adaptors.

J Mol Biol 2012 Sep 23;422(1):58-74. Epub 2012 May 23.

Department of Biochemistry and Molecular Biology, Leonard Miller School of Medicine, University of Miami, Miami, FL 33136, USA.

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http://dx.doi.org/10.1016/j.jmb.2012.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412936PMC
September 2012

Label-free quantitative LC-MS proteomics of Alzheimer's disease and normally aged human brains.

J Proteome Res 2012 Jun 17;11(6):3053-67. Epub 2012 May 17.

Department of Psychiatry and Behavioral Sciences, §Department of Biochemistry and Molecular Biology, ⊥Department of Epidemiology and Public Health, ▽Division of Neuroscience, and ○Department of Human Genetics and Genomics, University of Miami Miller School of Medicine , Miami, Florida, United States.

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http://dx.doi.org/10.1021/pr3001546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445701PMC
June 2012

Biophysical analysis of binding of WW domains of the YAP2 transcriptional regulator to PPXY motifs within WBP1 and WBP2 adaptors.

Biochemistry 2011 Nov 14;50(44):9616-27. Epub 2011 Oct 14.

Department of Biochemistry and Molecular Biology and USylvester Braman Family Breast Cancer Institute, Leonard Miller School of Medicine, University of Miami, Miami, Florida 33136, United States.

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http://dx.doi.org/10.1021/bi201286pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210484PMC
November 2011

Glycyrrhizin as antiviral agent against Hepatitis C Virus.

J Transl Med 2011 Jul 18;9:112. Epub 2011 Jul 18.

Division of Molecular Medicine, National Centre of Excellence in Molecular Biology, University of Punjab, Lahore, Pakistan.

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http://dx.doi.org/10.1186/1479-5876-9-112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169469PMC
July 2011

Inhibition of hepatitis C virus 3a genotype entry through Glanthus Nivalis Agglutinin.

Virol J 2011 May 20;8:248. Epub 2011 May 20.

Division of Molecular Medicine, Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan.

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http://dx.doi.org/10.1186/1743-422X-8-248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117843PMC
May 2011

Overexpression of ligase defective E6-associated protein, E6-AP, results in mammary tumorigenesis.

Breast Cancer Res Treat 2012 Feb 8;132(1):97-108. Epub 2011 May 8.

Department of Biochemistry and Molecular Biology, Braman Family Breast Cancer Institute (M-877)/Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, BRB Building, Room 723, 1501 NW 10th Avenue, Miami, FL 33136, USA.

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http://dx.doi.org/10.1007/s10549-011-1567-2DOI Listing
February 2012

E6-AP facilitates efficient transcription at estrogen responsive promoters through recruitment of chromatin modifiers.

Steroids 2011 Aug 19;76(9):897-902. Epub 2011 Apr 19.

Department of Biochemistry and Molecular Biology, Braman Family Breast Cancer Institute/Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1501 N.W. 10th Avenue, Miami, FL 33136, USA.

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http://dx.doi.org/10.1016/j.steroids.2011.04.007DOI Listing
August 2011

Lysosomotropic agents as HCV entry inhibitors.

Virol J 2011 Apr 12;8:163. Epub 2011 Apr 12.

Division of Molecular Medicine, National Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan.

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http://dx.doi.org/10.1186/1743-422X-8-163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090357PMC
April 2011

An overview of HCV molecular biology, replication and immune responses.

Virol J 2011 Apr 11;8:161. Epub 2011 Apr 11.

Division of Molecular Medicine, National Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan.

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http://dx.doi.org/10.1186/1743-422X-8-161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086852PMC
April 2011

In-vitro model systems to study Hepatitis C Virus.

Genet Vaccines Ther 2011 Apr 6;9. Epub 2011 Apr 6.

Division of Molecular Medicine, National Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan.

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http://dx.doi.org/10.1186/1479-0556-9-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083322PMC
April 2011

Inhibition of HCV 3a core gene through Silymarin and its fractions.

Virol J 2011 Apr 1;8:153. Epub 2011 Apr 1.

Division of Molecular Medicine, National Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan.

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http://virologyj.biomedcentral.com/articles/10.1186/1743-422
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http://dx.doi.org/10.1186/1743-422X-8-153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078856PMC
April 2011

Loss of Yes-associated protein (YAP) expression is associated with estrogen and progesterone receptors negativity in invasive breast carcinomas.

Breast Cancer Res Treat 2012 Feb 12;131(3):743-50. Epub 2011 Mar 12.

Department of Biochemistry and Molecular Biology, Braman Family Breast Cancer Institute/Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, BRB Building, Room 723, 1501 N.W. 10th Avenue, Miami, FL 33136, USA.

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http://dx.doi.org/10.1007/s10549-011-1435-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226897PMC
February 2012

Isoform-specific degradation of PR-B by E6-AP is critical for normal mammary gland development.

Mol Endocrinol 2010 Nov 9;24(11):2099-113. Epub 2010 Sep 9.

Department of Biochemistry & Molecular Biology, Braman Breast Cancer Institute (M-877), University of Miami School of Medicine, Batchelor Building, Room 416, 1580 Northwest 10 Avenue, Miami, Florida 33136, USA.

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http://dx.doi.org/10.1210/me.2010-0116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417378PMC
November 2010

E3 ubiquitin protein ligase, E6-associated protein (E6-AP) regulates PI3K-Akt signaling and prostate cell growth.

Biochim Biophys Acta 2011 Feb 6;1809(2):119-27. Epub 2010 Sep 6.

Department of Biochemistry & Molecular Biology, Universityof Miami Miller School of Medicine, Miami, FL 33136, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S18749399100011
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http://dx.doi.org/10.1016/j.bbagrm.2010.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031754PMC
February 2011

E6-associated protein (E6-AP) is a dual function coactivator of steroid hormone receptors.

Nucl Recept Signal 2008 Apr 18;6:e006. Epub 2008 Apr 18.

Department of Biochemistry and Molecular Biology, Braman Family Breast Cancer Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.

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http://dx.doi.org/10.1621/nrs.06006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2329825PMC
April 2008

Genotype/phenotype correlations in two patients with 12q subtelomere deletions.

Am J Med Genet A 2007 Nov;143A(22):2700-5

Department of Human Genetics, Emory University School of Medicine, Decatur, GA 30033-5207, USA.

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http://dx.doi.org/10.1002/ajmg.a.32005DOI Listing
November 2007

Long-range activation of GREB1 by estrogen receptor via three distal consensus estrogen-responsive elements in breast cancer cells.

Mol Endocrinol 2007 Nov 31;21(11):2651-62. Epub 2007 Jul 31.

Braman Family Breast Cancer Institute, 1580 NW 10 Avenue (M-877), University of Miami, Miami, Florida 33136, USA.

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http://dx.doi.org/10.1210/me.2007-0082DOI Listing
November 2007

Src promotes estrogen-dependent estrogen receptor alpha proteolysis in human breast cancer.

J Clin Invest 2007 Aug;117(8):2205-15

Braman Family Breast Cancer Institute and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.

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http://www.jci.org/articles/view/21739
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http://dx.doi.org/10.1172/JCI21739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906730PMC
August 2007

Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human osteoblast cells.

J Steroid Biochem Mol Biol 2007 Mar 12;103(3-5):368-71. Epub 2007 Jan 12.

Bone Metabolism Unit, Creighton University, School of Medicine, 601 North 30th Street, Omaha, NE 68131, USA.

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http://dx.doi.org/10.1016/j.jsbmb.2006.12.037DOI Listing
March 2007

WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors.

Mol Endocrinol 2006 Oct 13;20(10):2343-54. Epub 2006 Jun 13.

Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, Florida 33136, USA.

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https://academic.oup.com/mend/article-lookup/doi/10.1210/me.
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http://dx.doi.org/10.1210/me.2005-0533DOI Listing
October 2006

Complex agonist-like properties of ICI 182,780 (Faslodex) in human breast cancer cells that predominantly express progesterone receptor-B: implications for treatment resistance.

Int J Oncol 2005 Dec;27(6):1647-59

Dalton Cardiovascular Research Center and Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA.

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December 2005

Multifunction steroid receptor coactivator, E6-associated protein, is involved in development of the prostate gland.

Mol Endocrinol 2006 Mar 27;20(3):544-59. Epub 2005 Oct 27.

Department of Biochemistry and Molecular Biology, Braman Breast Cancer Institute (M-877), University of Miami Miller School of Medicine, Batchelor's Building, Room 416, 1580 Northwest 10 Avenue, Miami, Florida 33136, USA.

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http://dx.doi.org/10.1210/me.2005-0110DOI Listing
March 2006

Ubiquitin and control of transcription.

Essays Biochem 2005 ;41:69-80

Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, 1580 NW 10 Avenue, Miami, FL 33136, USA.

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http://dx.doi.org/10.1042/EB0410069DOI Listing
January 2006

Nuclear hormone receptor degradation and gene transcription: an update.

IUBMB Life 2005 Jul;57(7):483-90

Department of Biochemistry and Molecular Biology, Braman Family Breast Cancer Institute, University of Miami Miller School of Medecine, Miami, Florida 33136, USA.

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http://doi.wiley.com/10.1080/15216540500147163
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http://dx.doi.org/10.1080/15216540500147163DOI Listing
July 2005

Inhibition of the 26S proteasome blocks progesterone receptor-dependent transcription through failed recruitment of RNA polymerase II.

J Steroid Biochem Mol Biol 2005 Mar;94(4):337-46

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.jsbmb.2004.11.009DOI Listing
March 2005

Decreased expression of e6-associated protein in breast and prostate carcinomas.

Endocrinology 2005 Apr 3;146(4):1707-12. Epub 2005 Feb 3.

Cancer Center, Criss III, Room 352, Creighton University, 2500 California Plaza, Omaha, Nebraska 68178, USA.

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http://dx.doi.org/10.1210/en.2004-1198DOI Listing
April 2005

The ubiquitin-conjugating enzyme UBCH7 acts as a coactivator for steroid hormone receptors.

Mol Cell Biol 2004 Oct;24(19):8716-26

Cancer Center, Criss III, Room 352, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.24.19.8716-8726.2004
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http://dx.doi.org/10.1128/MCB.24.19.8716-8726.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC516762PMC
October 2004

Tamoxifen induces the expression of maspin through estrogen receptor-alpha.

Cancer Lett 2004 Jun;209(1):55-65

Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Alkek bldg, N630 Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.canlet.2003.11.018DOI Listing
June 2004

Urban renewal in the nucleus: is protein turnover by proteasomes absolutely required for nuclear receptor-regulated transcription?

Mol Endocrinol 2004 Mar 12;18(3):493-9. Epub 2003 Dec 12.

Cancer Center, Creighton University, Omaha, Nebraska 68178, USA.

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http://dx.doi.org/10.1210/me.2003-0388DOI Listing
March 2004

Nuclear hormone receptor co-regulators.

Curr Opin Drug Discov Devel 2003 Sep;6(5):692-701

Creighton University, CUMC-Cancer Center, Criss-II, Room 515, 2500 California Plaza, Omaha, NE 68178, USA.

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September 2003

4-ethoxymethylphenol: a novel phytoestrogen that acts as an agonist for human estrogen receptors.

J Steroid Biochem Mol Biol 2003 Mar;84(4):431-9

Department of Cell Biology, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, TX 75390-8595, USA.

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http://dx.doi.org/10.1016/s0960-0760(03)00064-5DOI Listing
March 2003

Specific ubiquitin-conjugating enzymes promote degradation of specific nuclear receptor coactivators.

Mol Endocrinol 2003 Jul 27;17(7):1315-31. Epub 2003 Mar 27.

Department of Surgery, Medical Microbiology & Immunology and Cancer Center Criss II, Creighton University, Omaha, Nebraska 68178, USA.

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http://dx.doi.org/10.1210/me.2002-0209DOI Listing
July 2003

Maturation of the regulation of GLUT4 activity by p38 MAPK during L6 cell myogenesis.

J Biol Chem 2003 May 11;278(20):17953-62. Epub 2003 Mar 11.

Programme in Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.

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http://dx.doi.org/10.1074/jbc.M211136200DOI Listing
May 2003

The roles of sex steroid receptor coregulators in cancer.

Mol Cancer 2002 Nov 14;1. Epub 2002 Nov 14.

CUMC-Cancer Center, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC149410PMC
http://dx.doi.org/10.1186/1476-4598-1-7DOI Listing
November 2002

Progesterone receptors - animal models and cell signaling in breast cancer: Role of steroid receptor coactivators and corepressors of progesterone receptors in breast cancer.

Breast Cancer Res 2002 28;4(5):182-6. Epub 2002 Jun 28.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC138741PMC
http://dx.doi.org/10.1186/bcr449DOI Listing
March 2003