Zabrina L Brumme

Zabrina L Brumme

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Zabrina L Brumme

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Rates and Correlates of Short Term Virologic Response among Treatment-Naïve HIV-Infected Children Initiating Antiretroviral Therapy in Ethiopia: A Multi-Center Prospective Cohort Study.

Pathogens 2019 Sep 24;8(4). Epub 2019 Sep 24.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institute, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.

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http://dx.doi.org/10.3390/pathogens8040161DOI Listing
September 2019

Nef-mediated inhibition of NFAT following TCR stimulation differs between HIV-1 subtypes.

Virology 2019 05 21;531:192-202. Epub 2019 Feb 21.

HIV Pathogenesis Programme, University of KwaZulu-Natal, Durban 4001, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2019.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526282PMC
May 2019

Modulation of TCR-dependent NFAT signaling is impaired in HIV-1 Nef isolates from elite controllers.

Virology 2019 04 11;530:39-50. Epub 2019 Feb 11.

Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada; Dept. of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2019.02.008DOI Listing
April 2019

Pol-Driven Replicative Capacity Impacts Disease Progression in HIV-1 Subtype C Infection.

J Virol 2018 10 12;92(19). Epub 2018 Sep 12.

HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa

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http://dx.doi.org/10.1128/JVI.00811-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146804PMC
October 2018

Inhibition of NF-κB-dependent HIV-1 replication by the marine natural product bengamide A.

Antiviral Res 2018 04 22;152:94-103. Epub 2018 Feb 22.

Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2018.02.017DOI Listing
April 2018

Transmitted/Founder HIV-1 Subtype C Viruses Show Distinctive Signature Patterns in Vif, Vpr, and Vpu That Are Under Subsequent Immune Pressure During Early Infection.

AIDS Res Hum Retroviruses 2016 Oct/Nov;32(10-11):1031-1045. Epub 2016 Jul 26.

1 Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health , Boston, Massachusetts.

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http://dx.doi.org/10.1089/AID.2015.0330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067802PMC
December 2017

Mother-to-Child HIV Transmission Bottleneck Selects for Consensus Virus with Lower Gag-Protease-Driven Replication Capacity.

J Virol 2017 09 10;91(17). Epub 2017 Aug 10.

HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa

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http://dx.doi.org/10.1128/JVI.00518-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553170PMC
September 2017

Potential for immune-driven viral polymorphisms to compromise antiretroviral-based preexposure prophylaxis for prevention of HIV-1 infection.

AIDS 2017 09;31(14):1935-1943

aAIDS Clinical Center, National Center for Global Health and Medicine, Tokyo bCenter for AIDS Research, Kumamoto University, Kumamoto, Japan cFaculty of Health Sciences, Simon Fraser University, Burnaby dBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada eDepartment of Paediatrics, University of Oxford, Oxford, UK fCentre for Research in Infectious Diseases, National Institute of Respiratory Diseases, Mexico City, Mexico gInfectious Diseases Clinic, Roosevelt Hospital, Guatemala City, Guatemala hNational Hospital of Tropical Diseases, Dong Da District, Hanoi, Vietnam iHIV National Laboratory, Honduran Ministry of Health jHospital Escuela Universitario, Tegucigalpa, Honduras kGorgas Memorial Institute for Health Studies, Panama City, Panama lHospital Metropolitano Vivian Pellas, Managua, Nicaragua mMinistry of Health, Belmopan, Belize nUniversity of California San Francisco, San Francisco, California oCancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory, Frederick, Maryland pRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA qMurdoch University, Perth, Australia rVanderbilt University, Nashville, Tennessee, USA sDepartment of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada.

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http://Insights.ovid.com/crossref?an=00002030-201709100-0000
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http://dx.doi.org/10.1097/QAD.0000000000001575DOI Listing
September 2017

In vitro functional assessment of natural HIV-1 group M Vpu sequences using a universal priming approach.

J Virol Methods 2017 02 16;240:32-41. Epub 2016 Nov 16.

Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jviromet.2016.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5183569PMC
February 2017

Novel Acylguanidine-Based Inhibitor of HIV-1.

J Virol 2016 10 29;90(20):9495-508. Epub 2016 Sep 29.

Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada Department of Molecular Biology and Biochemistry, Faculty of Sciences, Simon Fraser University, Burnaby, Canada

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http://dx.doi.org/10.1128/JVI.01107-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5044834PMC
October 2016

Toward Personalized Lymphoma Immunotherapy: Identification of Common Driver Mutations Recognized by Patient CD8+ T Cells.

Clin Cancer Res 2016 05 2;22(9):2226-36. Epub 2015 Dec 2.

Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency, Victoria, British Columbia, Canada. Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada. Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2023DOI Listing
May 2016

HIV-1 Vpu Mediates HLA-C Downregulation.

Cell Host Microbe 2016 May;19(5):686-95

Cancer and Inflammation Program, Leidos Biomedical Research, Frederick National Laboratory, Frederick, MD 21702, USA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139-3583, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2016.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904791PMC
May 2016

A strong association of human leukocyte antigen-associated Pol and Gag mutations with clinical parameters in HIV-1 subtype A/E infection.

AIDS 2016 Mar;30(5):681-9

aCenter for AIDS Research, Kumamoto University, Kumamoto, Japan beScience Group, Microsoft Research, Los Angeles, California, USA cNational Hospital of Tropical Diseases, Dong Da District, Hanoi, Vietnam dFaculty of Health Sciences, Simon Fraser University, Burnaby, BC, USA eAIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan fBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada gInternational Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan hNuffield Department of Medicine, University of Oxford, Oxford, UK. *Giang Van Tran and Takayuki Chikata contributed equally to this study.

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http://dx.doi.org/10.1097/QAD.0000000000000969DOI Listing
March 2016

Modest attenuation of HIV-1 Vpu alleles derived from elite controller plasma.

PLoS One 2015 20;10(3):e0120434. Epub 2015 Mar 20.

Department of Infectious Diseases, Integrative Virology, University Hospital Heidelberg, INF 324, Heidelberg, Germany; German Center for Infection Research, Heidelberg University, Heidelberg. Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0120434PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368696PMC
February 2016

Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences.

MBio 2016 Jan 19;7(1):e01516-15. Epub 2016 Jan 19.

Center for AIDS Research, Kumamoto University, Kumamoto, Japan International Research Center for Medical Sciences (IRCMS), Kumamoto University, Kumamoto, Japan

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http://dx.doi.org/10.1128/mBio.01516-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724998PMC
January 2016

A robust and scalable TCR-based reporter cell assay to measure HIV-1 Nef-mediated T cell immune evasion.

J Immunol Methods 2015 Nov 28;426:104-13. Epub 2015 Aug 28.

Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A1S6, Canada; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC V5A1S6, Canada; BC Centre for Excellence in HIV/AIDS, St. Paul's Hospital, Vancouver, BC V6Z1Y6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jim.2015.08.010DOI Listing
November 2015

Consequences of HLA-B*13-Associated Escape Mutations on HIV-1 Replication and Nef Function.

J Virol 2015 Nov 9;89(22):11557-71. Epub 2015 Sep 9.

Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada

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http://dx.doi.org/10.1128/JVI.01955-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645636PMC
November 2015

Global Database-Driven Assessment of HIV-1 Adaptation to the Immune Repertoires of Human Populations.

J Virol 2015 Oct 5;89(20):10693-5. Epub 2015 Aug 5.

British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada Department of Medicine, University of British Columbia, Vancouver, Canada

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http://dx.doi.org/10.1128/JVI.01355-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580167PMC
October 2015

Challenges and Opportunities for T-Cell-Mediated Strategies to Eliminate HIV Reservoirs.

Front Immunol 2015 2;6:506. Epub 2015 Oct 2.

Faculty of Health Sciences, Simon Fraser University , Burnaby, BC , Canada ; BC Centre for Excellence in HIV/AIDS , Vancouver, BC , Canada.

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http://dx.doi.org/10.3389/fimmu.2015.00506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591506PMC
October 2015

Differential Ability of Primary HIV-1 Nef Isolates To Downregulate HIV-1 Entry Receptors.

J Virol 2015 Sep 15;89(18):9639-52. Epub 2015 Jul 15.

Center for AIDS Research, Kumamoto University, Kumamoto, Japan International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan

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http://dx.doi.org/10.1128/JVI.01548-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542390PMC
September 2015

Dynamic range of Nef-mediated evasion of HLA class II-restricted immune responses in early HIV-1 infection.

Biochem Biophys Res Commun 2015 Jul 19;463(3):248-54. Epub 2015 May 19.

Center for AIDS Research, Kumamoto University, Kumamoto, Japan; International Research Center for Medical Sciences (IRCMS), Kumamoto University, Kumamoto, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.05.038DOI Listing
July 2015

Correction: Geographic and Temporal Trends in the Molecular Epidemiology and Genetic Mechanisms of Transmitted HIV-1 Drug Resistance: An Individual-Patient- and Sequence-Level Meta-Analysis.

PLoS Med 2015 Jun 1;12(6):e1001845. Epub 2015 Jun 1.

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http://dx.doi.org/10.1371/journal.pmed.1001845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452696PMC
June 2015

Immune screening identifies novel T cell targets encoded by antisense reading frames of HIV-1.

J Virol 2015 Apr 14;89(7):4015-9. Epub 2015 Jan 14.

IrsiCaixa AIDS Research Institute-HIVACAT, Hospital Germans Trias I Pujol, Badalona, Spain Institucio Catalana de Recerca i Estudis Avancats (ICREA), Barcelona, Spain University of Vic and Central University of Catalonia, Vic, Catalonia, Spain Autonomous University of Barcelona, Barcelona, Catalonia, Spain

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http://dx.doi.org/10.1128/JVI.03435-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403399PMC
April 2015

HIV-1 adaptation to HLA: a window into virus-host immune interactions.

Trends Microbiol 2015 Apr 19;23(4):212-24. Epub 2015 Jan 19.

Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.tim.2014.12.008DOI Listing
April 2015

Geographic and temporal trends in the molecular epidemiology and genetic mechanisms of transmitted HIV-1 drug resistance: an individual-patient- and sequence-level meta-analysis.

PLoS Med 2015 Apr 7;12(4):e1001810. Epub 2015 Apr 7.

Department of Medicine, Stanford University, Stanford, California, United States of America.

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http://dx.doi.org/10.1371/journal.pmed.1001810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388826PMC
April 2015

Nef-mediated down-regulation of CD4 and HLA class I in HIV-1 subtype C infection: association with disease progression and influence of immune pressure.

Virology 2014 Nov 3;468-470:214-225. Epub 2014 Sep 3.

HIV Pathogenesis Programme, University of KwaZulu-Natal, 719 Umbilo Road, Durban 4001, South Africa; KwaZulu-Natal Research Institute for Tuberculosis and HIV, University of KwaZulu-Natal, Durban 4001, South Africa; Ragon Institute of MGH, MIT and Harvard University, Cambridge, MA 02139, USA; Max Planck Institute for Infection Biology, Chariteplatz, D-10117 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2014.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252354PMC
November 2014

Impaired Nef function is associated with early control of HIV-1 viremia.

J Virol 2014 Sep 25;88(17):10200-13. Epub 2014 Jun 25.

Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, Canada Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada

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http://dx.doi.org/10.1128/JVI.01334-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136354PMC
September 2014

No evidence for selection of HIV-1 with enhanced gag-protease or Nef function among breakthrough infections in the CAPRISA 004 tenofovir microbicide trial.

PLoS One 2013 28;8(8):e71758. Epub 2013 Aug 28.

HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa ; KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa ; Institute of Infectious Disease and Molecular Medicine, and the Division of Medical Virology, University of Cape Town and National Health Laboratory Services, Cape Town, South Africa ; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada ; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0071758PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756015PMC
May 2014

Switching and emergence of CTL epitopes in HIV-1 infection.

Retrovirology 2014 May 21;11:38. Epub 2014 May 21.

Division of Infectious Diseases, Advanced Clinical Research Center, the Institute of Medical Science, the University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

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http://dx.doi.org/10.1186/1742-4690-11-38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036671PMC
May 2014

Structure of TCR and antigen complexes at an immunodominant CTL epitope in HIV-1 infection.

Sci Rep 2013 Nov 6;3:3097. Epub 2013 Nov 6.

Division of Infectious Diseases, Advanced Clinical Research Center, the Institute of Medical Science, the University of Tokyo. 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

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http://dx.doi.org/10.1038/srep03097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818656PMC
November 2013

Operationalizing the One Health approach: the global governance challenges.

Health Policy Plan 2013 Oct 7;28(7):778-85. Epub 2012 Dec 7.

Faculty of Health Sciences, Simon Fraser University, 8888 University Drive, Burnaby, BC, Canada V5A 1S6. E-mail:

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http://dx.doi.org/10.1093/heapol/czs127DOI Listing
October 2013

A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control.

Elife 2013 Oct 29;2:e01123. Epub 2013 Oct 29.

School of Life Sciences , École Polytechnique Fédérale de Lausanne , Lausanne , Switzerland ; Institute of Microbiology , University Hospital and University of Lausanne , Lausanne , Switzerland ; Research Group of Theoretical Biology and Evolutionary Ecology , Eötvös Loránd University and the Hungarian Academy of Sciences , Budapest , Hungary ; Swiss Institute of Bioinformatics , Lausanne , Switzerland.

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http://dx.doi.org/10.7554/eLife.01123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807812PMC
October 2013

Dynamic range of Nef functions in chronic HIV-1 infection.

Virology 2013 May 13;439(2):74-80. Epub 2013 Mar 13.

Center for AIDS Research, Kumamoto University, Kumamoto, Japan.

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http://dx.doi.org/10.1016/j.virol.2013.02.005DOI Listing
May 2013

A method for killer-cell immunoglobulin-like receptor (KIR) 3DL1/3DS1 genotyping using DNA recovered from frozen plasma.

J Immunol Methods 2013 May 21;391(1-2):154-62. Epub 2013 Mar 21.

Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.

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http://dx.doi.org/10.1016/j.jim.2013.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944815PMC
May 2013

Modulation of HIV reservoirs by host HLA: bridging the gap between vaccine and cure.

Curr Opin Virol 2012 Oct 29;2(5):599-605. Epub 2012 Aug 29.

Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/j.coviro.2012.08.003DOI Listing
October 2012

HLA class I sequence-based typing using DNA recovered from frozen plasma.

J Immunol Methods 2012 Aug 11;382(1-2):40-7. Epub 2012 May 11.

Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.

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http://dx.doi.org/10.1016/j.jim.2012.05.003DOI Listing
August 2012

Minor contribution of HLA class I-associated selective pressure to the variability of HIV-1 accessory protein Vpu.

Biochem Biophys Res Commun 2012 May 7;421(2):291-5. Epub 2012 Apr 7.

Center for AIDS Research, Kumamoto University, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2012.04.002DOI Listing
May 2012

Impact of HLA-B*81-associated mutations in HIV-1 Gag on viral replication capacity.

J Virol 2012 Mar 11;86(6):3193-9. Epub 2012 Jan 11.

HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.

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http://dx.doi.org/10.1128/JVI.06682-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302318PMC
March 2012

Immune-mediated attenuation of HIV-1.

Future Virol 2011 Aug;6(8):917-928

Simon Fraser University, Burnaby, BC, Canada.

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http://dx.doi.org/10.2217/fvl.11.68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292540PMC
August 2011