Publications by authors named "Z Jin"

6,359 Publications

White Matter but not Gray Matter Volumes are Associated with Cognition in Community-Dwelling Chinese Populations.

J Alzheimers Dis 2021 Sep 16. Epub 2021 Sep 16.

Department of Neurology , State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Few studies have investigated the association between cognition and brain volume associated with cerebral small vessel disease (CSVD).

Objective: We investigated the association between cognition and brain volume and neuroimaging markers of CSVD in a community-dwelling population.

Methods: Participants (n = 993, age≥35 years) from the community-based Shunyi Study were included to investigate the association between neuroimaging markers and cognition cross-sectionally. Magnetic resonance imaging markers included brain volume measurements of the total cerebrum, white matter, gray matter, and CSVD imaging markers. Cognitive performance was assessed using neuropsychological tests of the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Fuld Object Memory, digit span, Trail Making Test (TMT)-A, and TMT-B.

Results: For brain volume measurement, subcortical white matter fraction was positively associated with MMSE score (β= 0.034, p = 0.0062) and MoCA score (β= 0.034, p = 0.0174), and negatively associated with TMT-A and TMT-B completion time (β= -2.319, p = 0.0002; β= -2.827, p = 0.0073, respectively). For evaluation of CSVD imaging markers, the presence of lacunes was positively associated with TMT-B completion time (β= 17.241, p = 0.0028).

Conclusion: In community-dwelling populations, reduced white matter volumes, as a consequence of aging and vascular damage, are associated with worse global cognition and executive function. Our findings provide potential insights into the correlation between cognition and CSVD-associated subcortical white matter injury.
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http://dx.doi.org/10.3233/JAD-210367DOI Listing
September 2021

A review of the clinical and engineering performance of dual-mobility cups for total hip arthroplasty.

Am J Transl Res 2021 15;13(8):9383-9394. Epub 2021 Aug 15.

School of Mechanical Engineering, Southwest Jiaotong University Chengdu 610031, China.

Charnley's low-friction principle of total hip arthroplasty (THA) is recognized as the gold standard. However, complications may arise, and one of the major reasons for revising THA is dislocation. Under such a background, Pr. Gilles Bousquet invented dual-mobility cups (DMC) in the 1970s to fight against hip instability. Despite the excellent clinical results of DMC compared with conventional implants, the clinical application of DMC is limited by concerns about the dual articulations, leading to rapid wear and the subsequent osteolysis and the wear on the retaining rim of the liner due to its contact with the femoral neck causing intraprosthetic dislocation (IPD). As a result, the original design of DMC has been upgraded by using highly cross-linked polyethylene, refining the geometry of the femoral neck, etc. After the improvement, the wear rate of the contemporary DMC liners has been largely reduced compared with the first generation DMC, and the IPD incidence rate has been controlled. However, with the increasing fretting corrosion damage found at the taper-trunnion interfaces in conventional implants, the contemporary DMC may face a similar problem. This is because the additional articulation and the larger head design of DMC gain the risk of articulation wear and taper-trunnion interface corrosion. Since there are still many potential DMC engineering issues that have not been extensively researched, future studies focusing on the wear and corrosion aspects are required. The purpose of this review article is to summarize both the clinical and engineering issues for DMC with possible directions for future research.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430055PMC
August 2021

Endometrial thickness changes after progesterone administration do not affect the pregnancy outcomes of frozen-thawed euploid blastocyst transfer: a retrospective cohort study.

Fertil Steril 2021 Sep 15. Epub 2021 Sep 15.

Reproductive Medical Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China. Electronic address:

Objective: To evaluate whether the change in endometrial thickness from progesterone administration day to transfer day is related to pregnancy outcomes in single frozen-thawed euploid blastocyst transfer cycles.

Design: Observational cohort study.

Setting: Single reproductive medical center.

Patient(s): All patients were transferred with a single biopsied euploid blastocyst, and their endometrium was prepared with hormone replacement therapy (HRT).

Intervention(s): The endometrial thickness on the day of blastocyst transfer and progesterone administration was measured by transvaginal ultrasound, and the difference between them and the change ratio were calculated.

Main Outcome Measure(s): Clinical pregnancy rates and live birth rates.

Result(s): Endometrial ultrasound images of 508 euploid blastocyst transfer cycles using HRT were evaluated by transvaginal ultrasound. Overall, pregnancy outcomes were comparable in different groups of endometrial thickness changes. The results of multiple logistic regression showed that the clinical pregnancy rate and live birth rate did not significantly increase with the increase in endometrial thickness change ratios (per 10%) in the fully adjusted model as a continuous variable. In the adjustment model as a categorical variable, there was no statistical difference in pregnancy outcomes among the groups with changes in endometrial thickness. Interaction analysis showed that after adjusting for confounders, there was no statistically significant interaction between the endometrial thickness change ratio and pregnancy outcomes in all subgroups.

Conclusion(s): In the euploid blastocyst transfer cycle of preparing the endometrium with HRT, the endometrial thickness change ratio after progesterone administration was not related to pregnancy outcomes.
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http://dx.doi.org/10.1016/j.fertnstert.2021.08.008DOI Listing
September 2021

TRIM59: A potential diagnostic and prognostic biomarker in human tumors.

PLoS One 2021 17;16(9):e0257445. Epub 2021 Sep 17.

Department of Orthopaedic Trauma, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong Province, China.

TRIM59 is a protein that is highly expressed in a variety of tumors and promotes tumor development. However, the use of TRIM59 as tumor diagnosis and prognosis biomarker has not been fully explored. We collected datasets from the cancer genome atlas (TCGA) and gene expression omnibus (GEO) to investigate its potential as a biomarker for diagnosis and prognosis. A total of 46 studies, including 11,558 patients were included in this study. Here, we showed that TRIM59 was significantly upregulated in 15 type of human solid tumors in comparison to their adjacent tissues. Receiver operating characteristic curve (ROC) results provided further evidence for the use of TRIM59 as a potential tumor diagnosis biomarker. Overall survival (OS) was compared between TRIM59 high expression and low expression groups. High expression of TRIM59 indicated a poor prognosis in multiple solid tumors. Taken together, these analyses showed that TRIM59 was upregulated in various types of tumors and had the potential to be used as a diagnostic and prognostic biomarker in human solid tumors.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0257445PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448305PMC
September 2021
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