Yvonne Bombard

Yvonne Bombard

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Yvonne Bombard

Publications by authors named "Yvonne Bombard"

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Primary care provider perspectives on using genomic sequencing in the care of healthy children.

Eur J Hum Genet 2019 Dec 5. Epub 2019 Dec 5.

Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/s41431-019-0547-6DOI Listing
December 2019

What do we do now?: Responding to claims of germline gene editing in humans.

Genet Med 2019 10 27;21(10):2181-2183. Epub 2019 Mar 27.

Department of Genetics and Stanford Center for Biomedical Ethics, Stanford School of Medicine, Stanford, CA, USA.

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http://dx.doi.org/10.1038/s41436-019-0492-3DOI Listing
October 2019

Variant classification changes over time in BRCA1 and BRCA2.

Genet Med 2019 10 11;21(10):2248-2254. Epub 2019 Apr 11.

Department of Pathology and Laboratory Medicine, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/s41436-019-0493-2DOI Listing
October 2019

Correction: Variant classification changes over time in BRCA1 and BRCA2.

Genet Med 2019 Oct;21(10):2406-2407

Department of Pathology and Laboratory Medicine, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/s41436-019-0526-xDOI Listing
October 2019

Attitudes of Members of Genetics Professional Societies Toward Human Gene Editing.

CRISPR J 2019 Oct;2(5):331-339

Department of Genetics, Stanford University School of Medicine, Stanford, California.

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http://dx.doi.org/10.1089/crispr.2019.0020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791481PMC
October 2019

The clinical application of gene editing: ethical and social issues.

Per Med 2019 07 23;16(4):337-350. Epub 2019 Jul 23.

Biomedical Ethics Research Program & Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.2217/pme-2018-0155DOI Listing
July 2019

Recontacting clinical genetics patients with reclassified results: equity and policy challenges.

Eur J Hum Genet 2019 Apr;27(4):505-506

Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.

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http://www.nature.com/articles/s41431-018-0313-1
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http://dx.doi.org/10.1038/s41431-018-0313-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460896PMC
April 2019

The Responsibility to Recontact Research Participants after Reinterpretation of Genetic and Genomic Research Results.

Am J Hum Genet 2019 Apr;104(4):578-595

Social Issues Committee, American Society of Human Genetics, Rockville, MD 20852, USA; Division of General Internal Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.ajhg.2019.02.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451731PMC
April 2019

Genome-wide sequencing in acutely ill infants: genomic medicine's critical application?

Genet Med 2019 02 12;21(2):498-504. Epub 2018 Jun 12.

Centre of Genomics and Policy, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1038/s41436-018-0055-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752673PMC
February 2019

Engaging patients to improve quality of care: a systematic review.

Implement Sci 2018 07 26;13(1):98. Epub 2018 Jul 26.

Départment de Gestion, d'Évaluation et de Politique de Santé, École de santé Publique, Université de Montréal, Centre de recherche du CHUM, Carrefour de l'innovation et de l'évaluation en santé, 850 rue Saint-Denis, Montréal, Quebec, H2X 0A9, Canada.

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http://dx.doi.org/10.1186/s13012-018-0784-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060529PMC
July 2018

The Genetic Non-Discrimination Act: critical for promoting health and science in Canada.

CMAJ 2018 05;190(19):E579-E580

Institute of Health Policy, Management and Evaluation, University of Toronto (Bombard); Li Ka Shing Knowledge Institute, St. Michael's Hospital (Bombard), Toronto, Ont.; Huntington Society of Canada (Heim-Myers); Canadian Coalition for Genetic Fairness (Heim-Myers), Kitchener, Ont.

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http://dx.doi.org/10.1503/cmaj.180298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953574PMC
May 2018

The Personal Genome Project Canada: findings from whole genome sequences of the inaugural 56 participants.

CMAJ 2018 02;190(5):E126-E136

The Centre for Applied Genomics (Reuter, Walker, Thiruvahindrapuram, Whitney, Yuen, Trost, Paton, Pereira, Herbrick, Wintle, Merico, Howe, MacDonald, Lu, Nalpathamkalam, Sung, Wang, Patel, Pellecchia, J. Wei, Strug, Bell, Kellam, Mahtani, Hosseini, Fiume, Marshall, Buchanan, Scherer); Divisions of Clinical Pharmacology and Toxicology (I. Cohn), or Clinical, and Metabolic Genetics (Sondheimer, Weksberg, Shuman, Bowdin, Meyn, Monfared), The Hospital for Sick Children; Departments of Paediatrics (Sondheimer, R. Cohn) and Molecular Genetics (Yuen, Weksberg, Shuman, R. Cohn, Ellis, Meyn), University of Toronto; Deep Genomics Inc. (Merico); Department of Psychiatry (Bassett), University Health Network and Centre for Addiction and Mental Health, University of Toronto; Li Ka Shing Knowledge Institute (Bombard), St. Michael's Hospital; Institute of Health Policy, Management and Evaluation (Bombard), University of Toronto; Centre for Genetic Medicine (Stavropoulos, Bowdin, Ray, Monfared); Molecular Genetics Laboratory (Stavropoulos, Ray, Marshall), Division of Genome Diagnostics, Paediatric Laboratory Medicine; Developmental and Stem Cell Biology (Hildebrandt, W. Wei, Romm, Pasceri, Ellis); Ted Rogers Cardiac Genome Clinic (Hosseini); Cytogenetics Laboratory (Joseph-George), Division of Genome Diagnostics, Paediatric Laboratory Medicine, The Hospital for Sick Children; Departments of Biochemistry and Laboratory Medicine, and Pathobiology (Keeley), University of Toronto; DNAstack (Cook, Fiume); McLaughlin Centre (Lee, Scherer), University of Toronto; Medcan Health Management Inc. (Davies, Hazell); Dalla Lana School of Public Health (Szego), Department of Family and Community Medicine, and The Joint Centre for Bioethics, University of Toronto; Centre for Clinical Ethics (Szego), St. Joseph's Health Centre, Toronto, Ont.

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http://dx.doi.org/10.1503/cmaj.171151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798982PMC
February 2018

Universal tumor screening for Lynch syndrome: health-care providers' perspectives.

Genet Med 2017 05 6;19(5):568-574. Epub 2016 Oct 6.

Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/gim.2016.150DOI Listing
May 2017

Psychosocial Response to Uncertain Newborn Screening Results for Cystic Fibrosis.

J Pediatr 2017 05 6;184:165-171.e1. Epub 2017 Mar 6.

Child Health Evaluative Sciences, The Hospital for Sick Children Research Institute, Toronto, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada; Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, Canada; Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada; Health System Planning & Evaluation Research Program, Institute for Clinical Evaluative Sciences, Toronto, Canada.

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http://dx.doi.org/10.1016/j.jpeds.2017.01.049DOI Listing
May 2017

Q-SEA - a tool for quality assessment of ethics analyses conducted as part of health technology assessments.

GMS Health Technol Assess 2017 15;13:Doc02. Epub 2017 Mar 15.

Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.3205/hta000128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352988PMC
March 2017

Parent Experience With False-Positive Newborn Screening Results for Cystic Fibrosis.

Pediatrics 2016 09 2;138(3). Epub 2016 Aug 2.

Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada; Institute of Health Policy, Management and Evaluation, Departments of Pediatrics and Pediatric Medicine, and Institute for Clinical Evaluative Sciences, Toronto, Canada.

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http://dx.doi.org/10.1542/peds.2016-1052DOI Listing
September 2016

The influence of gene expression profiling on decisional conflict in decision making for early-stage breast cancer chemotherapy.

Eur J Cancer 2016 07 4;61:85-93. Epub 2016 May 4.

Department of Community Health Sciences, University of Calgary, McMaster University, Room 3C56, Health Research Innovation Centre, 3280 Hospital Drive NW, Calgary, Alberta T2N 4Z6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2016.03.077DOI Listing
July 2016

Using Newborn Screening Bloodspots for Research: Public Preferences for Policy Options.

Pediatrics 2016 06 17;137(6). Epub 2016 May 17.

Department of Family and Community Medicine, Sinai Health System, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1542/peds.2015-4143DOI Listing
June 2016

Translating personalized genomic medicine into clinical practice: evidence, values, and health policy.

Authors:
Yvonne Bombard

Genome 2015 Dec 18;58(12):491-7. Epub 2015 Nov 18.

Li Ka Shing Knowledge Institute of St. Michael's Hospital, Institute of Health Policy, Management & Evaluation, University of Toronto.

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http://dx.doi.org/10.1139/gen-2015-0145DOI Listing
December 2015

Public Perceptions of the Benefits and Risks of Newborn Screening.

Pediatrics 2015 Aug 13;136(2):e413-23. Epub 2015 Jul 13.

School of Population and Public Health, University of British Columbia, Vancouver, Canada; and Canadian Centre for Applied Research in Cancer Control, BC Cancer Agency, Vancouver, Canada.

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http://dx.doi.org/10.1542/peds.2015-0518DOI Listing
August 2015

The value of personalizing medicine: medical oncologists' views on gene expression profiling in breast cancer treatment.

Oncologist 2015 Apr 6;20(4):351-6. Epub 2015 Mar 6.

Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada; Insititute of Health Policy, Management and Evaluation, Department of Medicine, and Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada; Independent Qualitative Researcher; Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Princess Margaret Cancer Centre, Toronto, Ontario, Canada; DeGroote School of Business, McMaster University, Hamilton, Ontario, Canada; Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada; Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1634/theoncologist.2014-0268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391763PMC
April 2015

Public views on participating in newborn screening using genome sequencing.

Eur J Hum Genet 2014 Nov 19;22(11):1248-54. Epub 2014 Feb 19.

1] Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada [2] Newborn Screening Ontario, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1038/ejhg.2014.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200434PMC
November 2014

Citizens' perspectives on personalized medicine: a qualitative public deliberation study.

Eur J Hum Genet 2013 Nov 23;21(11):1197-201. Epub 2013 Jan 23.

Yale University, School of Public Health & Memorial Sloan-Kettering Cancer Center, Center for Health Policy and Outcomes and Clinical Genetics Service, New York, NY, USA.

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http://dx.doi.org/10.1038/ejhg.2012.300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798829PMC
November 2013

Translating genomics in cancer care.

J Natl Compr Canc Netw 2013 Nov;11(11):1343-53

From the aCenter for Health Policy and Outcomes, Department of Epidemiology and Biostatistics, and bClinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York; and cSchool of Public Health, Department of Epidemiology and Public Health, Yale University, New Haven, Connecticut.

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http://dx.doi.org/10.6004/jnccn.2013.0158DOI Listing
November 2013

Assessing the impacts of citizen deliberations on the health technology process.

Int J Technol Assess Health Care 2013 Jul;29(3):282-9

Department of Clinical Epidemiology & Biostatistics, Centre for Health Economics and Policy Analysis, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1017/S0266462313000299DOI Listing
July 2013

Risks to relatives in genomic research: a duty to warn?

Am J Bioeth 2012 ;12(10):12-4

Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://www.tandfonline.com/doi/abs/10.1080/15265161.2012.699
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http://dx.doi.org/10.1080/15265161.2012.699157DOI Listing
November 2012

An equity framework for health technology assessments.

Med Decis Making 2012 May-Jun;32(3):428-41. Epub 2011 Nov 7.

Department of Health Policy, Management and Evaluation, University of Toronto, Canada (YB)

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http://dx.doi.org/10.1177/0272989X11426484DOI Listing
September 2012

Beyond the patient: the broader impact of genetic discrimination among individuals at risk of Huntington disease.

Am J Med Genet B Neuropsychiatr Genet 2012 Mar 9;159B(2):217-26. Epub 2012 Jan 9.

Department of Medical Genetics, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1002/ajmg.b.32016DOI Listing
March 2012

Citizens' values regarding research with stored samples from newborn screening in Canada.

Pediatrics 2012 Feb 16;129(2):239-47. Epub 2012 Jan 16.

Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1542/peds.2011-2572DOI Listing
February 2012

When they hear what we say: ethical challenges in presenting research findings to the Huntington disease community.

J Empir Res Hum Res Ethics 2011 Sep;6(3):47-54

Department of Health Policy Management and Evaluation, University of Toronto, Ontario, Canada.

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http://journals.sagepub.com/doi/10.1525/jer.2011.6.3.47
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http://dx.doi.org/10.1525/jer.2011.6.3.47DOI Listing
September 2011

Eliciting ethical and social values in health technology assessment: A participatory approach.

Soc Sci Med 2011 Jul 23;73(1):135-44. Epub 2011 May 23.

Department of Health Policy Management and Evaluation, University of Toronto, 155 College Street, 4th Floor, Toronto, Ontario, Canada M5T 3M6.

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http://dx.doi.org/10.1016/j.socscimed.2011.04.017DOI Listing
July 2011

Factors associated with experiences of genetic discrimination among individuals at risk for Huntington disease.

Am J Med Genet B Neuropsychiatr Genet 2011 Jan 10;156B(1):19-27. Epub 2010 Nov 10.

Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1002/ajmg.b.31130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860279PMC
January 2011

Reconsidering reproductive benefit through newborn screening: a systematic review of guidelines on preconception, prenatal and newborn screening.

Eur J Hum Genet 2010 Jul 3;18(7):751-60. Epub 2010 Mar 3.

Department of Health Policy, Management and Evaluation, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

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http://www.nature.com/articles/ejhg201013
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http://dx.doi.org/10.1038/ejhg.2010.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987364PMC
July 2010

Perception, experience, and response to genetic discrimination in Huntington disease: the international RESPOND-HD study.

Am J Med Genet B Neuropsychiatr Genet 2010 Jul;153B(5):1081-93

Department of Family Medicine, John P. McGovern Center for Health, Humanities and the Human Spirit, University of Texas Medical School at Houston, Houston, Texas, USA.

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http://dx.doi.org/10.1002/ajmg.b.31079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593716PMC
July 2010

The expansion of newborn screening: is reproductive benefit an appropriate pursuit?

Nat Rev Genet 2009 Oct;10(10):666-7

Faculty of Medicine, Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/nrg2666DOI Listing
October 2009

Engagement with genetic discrimination: concerns and experiences in the context of Huntington disease.

Eur J Hum Genet 2008 Mar 24;16(3):279-89. Epub 2007 Oct 24.

Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1038/sj.ejhg.5201937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806301PMC
March 2008

Psychosocial effects of predictive testing for Huntington's disease.

Adv Neurol 2005 ;96:226-39

Department of Medical Genetics, Centrefor Molecular Medicine and Therapeutics, Children's and Women's Health Centre of British Columbia, University of British Columbia, Vancouver, Canada.

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February 2006

Genetic testing and Huntington's disease: issues of employment.

Lancet Neurol 2004 Apr;3(4):249-52

Institute of Medical Genetics, University of Wales College of Medicine, Cardiff, UK.

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http://dx.doi.org/10.1016/S1474-4422(04)00711-2DOI Listing
April 2004