Publications by authors named "Yuze Zhang"

10 Publications

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Comparing the self-perceived effects of a facial anti-aging product to those automatically detected from selfie images of Chinese women of different ages and cities.

Skin Res Technol 2021 Apr 6. Epub 2021 Apr 6.

ModiFace, A L'Oréal Group Company, Toronto, ON, Canada.

Objective: To assess the agreement, after 1-month application of a popular and efficient anti-aging product, between self-perceived facial signs of aging and those detected and graded by an automatic A.I-based system, using smartphones' selfie images.

Material And Methods: Of 1065 Chinese women, aged 18-60 years, from eight different Chinese cities were recruited. They were asked to apply daily, for 1 month, a referential anti-aging product onto their whole face. Selfie images were taken by all subjects at D and D and sent to our facilities for being analyzed through 10 different facial signs. At D , all subjects were asked to fill a questionnaire on the status of their faces, through six general statements.

Results: A global agreement between both approaches is reached, particularly among women older than 40 years where the severity of facial signs is already more pronounced or among younger women who present at least facial signs scored above one grading units. This limit becomes, therefore, a prerequisite in the recruitment of Chinese subjects in the case of anti-aging applied studies and possible automatically based on automatic grading system. When respecting such conditions, the positive effects of the product on most facial signs can be demonstrated after 28 days of successive applications.

Conclusion: Such methodological approach paves the road in fulfilling the need of consumers of a better transparency in the claims of an anti-aging product.
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http://dx.doi.org/10.1111/srt.13037DOI Listing
April 2021

Synthesis and application of low-cost layered double hydroxides intercalated by gluconic acid anion for flame retardancy and tensile strength conservation of high filling epoxy resin.

J Colloid Interface Sci 2021 Jul 18;594:791-801. Epub 2021 Mar 18.

Key Laboratory of Comprehensive and Highly Efficient Utilization of Salt Lake Resources, Qinghai Institute of Salt Lakes, Chinese Academy of Sciences, Xining 810008, Qinghai, China; Qinghai Engineering and Technology Research Center of Comprehensive Utilization of Salt Lake Resources, Xining 810008, Qinghai, China. Electronic address:

Epoxy resin (EP) is a polymer that is widely used in different aspects of life, but its flammability property limits its fields of applications. Most flame retardants at present cannot be applied practically in scale due to their toxicity, incompatibility in polymers, degraded mechanical property or high cost of raw materials and comprehensive preparation process. Layered double hydroxides intercalated by gluconic acid anion (GLDHs) may serve as a new approach. GLDHs with Mg/Al ratio of 3/1 and 2/1 were first coprecipitated with low-cost green reactants, MgCl·6HO, AlCl·6HO, NaOH and sodium gluconate. Their structures were confirmed by X-ray diffractions (XRD), transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FTIR) and elemental analysis; their thermal properties were analyzed by thermo gravimetric analysis (TGA). Composites containing 40 wt.% GLDHs were easily manufactured with normal magnetic stirring without any filler precipitation. The combustion properties of the composites filled with 40 wt.% GLDHs2 are as follows: the limit oxygen index (LOI) could rise to 29.8% from 25.2% of pristine EP; UL-94 can reach V-1 level with total burning time of only 12.1 s without dropping; compared to pristine EP, the heat release rate peak (PHRR) could drop to 30% with heavy decrease in the smoke production rate and CO production rate. Dynamic mechanical thermal analysis (DMA) tests showed that the addition of 40 wt.% GLDHs had little impact on the glass transition temperature of the composites and could slightly improve their rigidity and toughness. Tensile strength of the composites filled with 40 wt.% GLDHs2 was almost close to 88% of the tensile strength of pristine EP. Above all, GLDHs with good compatibility in polymers can serve as a promising environmental friendly and low-cost flame retardant for EP and other heterochain polymers.
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http://dx.doi.org/10.1016/j.jcis.2021.03.088DOI Listing
July 2021

Japanese experiment of a complete and objective automatic grading system of facial signs from selfie pictures: Validation with dermatologists and characterization of changes due to age and sun exposures.

Skin Res Technol 2020 Dec 27. Epub 2020 Dec 27.

L'Oréal Research and Innovation, Clichy, France.

Objective: To evaluate the capacity of the automatic detection system to accurately grade, from smartphones' selfie pictures, the severity of ten facial signs in Japanese women and their changes due to age and sun exposures.

Methods: A three-step approach was conducted, based on self-taken selfie images. At first, to check on 310 Japanese women (18-69 years) enrolled in the northerner Hokkaido area (latitude 43.2°N), how, on ten facial signs, the A.I-based automatic grading system may correlate with dermatological assessments, taken as reference. Second, to assess and compare age changes in 310 Japanese and 112 Korean women. Third, as these Japanese panelists were recruited according to their usual behavior toward sun exposure, that is, non-sun-phobic (NSP, N = 114) and sun-phobic (SP, N = 196), and through their regular and early use of a photo-protective product, to characterize the facial photo-damages.

Results: (a) On the ten facial signs, detected automatically, nine were found significantly (P < .0001) highly correlated with the evaluations made by three Japanese dermatologists (Wrinkles: r = .75; Sagging: r = .80; Pigmentation: r = .75). (b) The automatic scores showed significant changes with age, by decade, of Wrinkles/Texture, Pigmentation, and Ptosis/Sagging (P < .05). (c) After 45 years, a significantly increased severity of Wrinkles/Texture and Pigmentation was observed in NSP vs. SP women (P < .05). A trend of an increased Ptosis/Sagging (P = .09) was observed.

Conclusion: This work illustrates, for the first time through investigations conducted at home, some impacts of aging and sun exposures on facial signs of Japanese women. Results significantly confirm the importance of sun avoidance coupled with photo-protective measures. In epidemiological studies, the AI-based system offers a fast, affordable, and confidential approach in detection and quantification of facial signs and their dependence with ages, environments and lifestyles.
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http://dx.doi.org/10.1111/srt.12982DOI Listing
December 2020

The cyclic adenosine monophosphate elevating medicine, forskolin, reduces neointimal formation and atherogenesis in mice.

J Cell Mol Med 2020 09 18;24(17):9638-9645. Epub 2020 Aug 18.

State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Neointimal formation and atherogenesis are major vascular complications following percutaneous coronary intervention, and there is lack of pharmacological therapy. This study was aimed to examine the effect of forskolin (FSK), a cyclic adenosine monophosphate (cAMP)-elevating agent, on vascular response to angioplasty wire injury and on atherogenesis in mice. Forskolin treatment reduced neointima formation at 7 and 28 days after wire injury. Early morphometrics of the injured vessels revealed that FSK treatment enhanced endothelial repair and reduced inflammatory cell infiltration. In vitro treatment of primary aortic cells with FSK, at 3-100 μmol/L, increased endothelial cell proliferation, whereas FSK, at 30-100 μmol/L, inhibited smooth muscle cell proliferation. FSK inhibited lipopolysaccharide-induced leucocyte-endothelial interaction in vitro and in vivo. In a mouse model of atherosclerosis driven by dyslipidaemia and hypertension, FSK administration increased endothelial repair and reduced atherosclerotic plaque formation, without affecting blood pressure, plasma lipids or aortic aneurysms formation. In summary, FSK, at doses relevant to human therapeutic use, protects against neointimal hyperplasia and atherogenesis, and this is attributable to its activities on pro-endothelial repair and anti-inflammation. This study raises a potential of clinical use of FSK as an adjunct therapy to prevent restenosis and atherosclerosis after percutaneous coronary intervention.
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http://dx.doi.org/10.1111/jcmm.15476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520276PMC
September 2020

The continuous development of a complete and objective automatic grading system of facial signs from selfie pictures: Asian validation study and application to women of three ethnic origins, differently aged.

Skin Res Technol 2021 Mar 20;27(2):183-190. Epub 2020 Jul 20.

ModiFace - A L'Oréal Group Company, Toronto, ON, Canada.

Objective: To evaluate the capacity of the automatic detection system to accurately grade, from smartphones' selfie pictures, the severity of seven new facial signs added to the nine previously integrated.

Methods: A two-step approach was conducted: first, to check on 112 Korean women, how the AI-based automatic grading system may correlate with dermatological assessments, taken as reference; second, to confirm on 1140 women of three ancestries (African, Asian, and Caucasian) the relevance of the newly input facial signs.

Results: The sixteen specific Asian facial signs, detected automatically, were found significantly (P < .0001) highly correlated with the clinical evaluations made by two Korean dermatologists (wrinkles: r = .90; sagging: r = .75-.95; vascular: r = .85; pores: r = .60; pigmentation: r = .50-.80). When applied at a larger scale on women of different ethnicities, new signs were found of good accuracy and reproducibility, albeit depending on ethnicity. Due to contrast with the innate skin complexion, the facial signs dealing with skin pigmentation were found of a much higher relevance among Asian women than African or Caucasian women. The automatic gradings were even found of a slightly higher accuracy than the clinical gradings.

Conclusion: The previously used automatic grading system is now completed by adding new facial signs apt at being detected. The continuous development is now integrating some limitations with regard to the constitutive skin complexion of the self-pictured subjects. Presenting reproducible assessments, highly correlated with medical grading, this system could change tremendously clinical researches, like in epidemiological studies, where it offers an easy, fast, affordable, and confidential approach in the objective quantification of facial signs.
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http://dx.doi.org/10.1111/srt.12922DOI Listing
March 2021

Cardiovascular Biology of Prostanoids and Drug Discovery.

Arterioscler Thromb Vasc Biol 2020 06 16;40(6):1454-1463. Epub 2020 Apr 16.

From the State Key Laboratory of Cardiovascular Disease (L.Z., Y.Z., Z.G., M.W.), Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing.

Prostanoids are a group of bioactive lipids that are synthesized de novo from membrane phospholipid-released arachidonic acid and have diverse functions in normal physiology and disease. NSAIDs (non-steroidal anti-inflammatory drugs), which are among the most commonly used medications, ameliorate pain, fever, and inflammation by inhibiting COX (cyclooxygenase), which is the rate-limiting enzyme in the biosynthetic cascade of prostanoids. The use of NSAIDs selective for COX-2 inhibition increases the risk of a thrombotic event (eg, myocardial infarction and stroke). All NSAIDs are associated with an increased risk of heart failure. Substantial variation in clinical responses to aspirin exists and is associated with cardiovascular risk. Limited clinical studies suggest the involvement of prostanoids in vascular restenosis in patients who received angioplasty intervention. mPGES (microsomal PG [prostaglandin] E synthase)-1, an alternative target downstream of COX, has the potential to be therapeutically targeted for inflammatory disease, with diminished thrombotic risk relative to selective COX-2 inhibitors. mPGES-1-derived PGE critically regulates microcirculation via its receptor EP (receptor for prostanoid E) 4. This review summarizes the actions and associated mechanisms for modulating the biosynthesis of prostanoids in thrombosis, vascular remodeling, and ischemic heart disease as well as their therapeutic relevance.
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http://dx.doi.org/10.1161/ATVBAHA.119.313234DOI Listing
June 2020

Drug Discovery for Coronary Artery Disease.

Adv Exp Med Biol 2020 ;1177:297-339

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.

Cardiovascular disease is the number one cause of human morbidity and mortality worldwide. Although cholesterol-lowering drugs, including statins and recently approved PCSK9 inhibitors, together with antithrombotic drugs have been historically successful in reducing the occurrence of coronary artery disease (CAD), the high incidence of CAD remains imposing the largest disease burden on our healthcare systems. We reviewed cardiovascular drugs recently approved or under clinical development, with a particular focus on their pharmacology and limitations. New agents targeting cholesterol/triglyceride lowering bear promise of further cardiovascular risk reduction. Some new antidiabetic agents show cardiovascular benefit in patients with diabetes. Improved antithrombotic agents with diminished bleeding risk are in clinical development. The recent clinical success of the IL-1β antibody in reducing atherothrombosis opens a new era of therapeutic discovery that targets inflammation. Chinese traditional medicine and cardiac regeneration are also discussed. Human genetics studies of CAD and further delineation of key determinants/pathways underlying the residual risk of CAD under current standard therapy will continue to fuel the pipeline of cardiovascular drug discovery.
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http://dx.doi.org/10.1007/978-981-15-2517-9_8DOI Listing
April 2020

Mass conservative lattice Boltzmann scheme for a three-dimensional diffuse interface model with Peng-Robinson equation of state.

Phys Rev E 2018 Aug;98(2-1):023306

Department of Applied Mathematics, The Hong Kong Polytechnic University, Hung Hom, Hong Kong.

Peng-Robinson (P-R) equation of state (EOS) has been widely used in the petroleum industry for hydrocarbon fluids. In this work, a three-dimensional diffuse interface model with P-R EOS for two-phase fluid system is solved by the lattice Boltzmann (LB) method. In this diffuse interface model, an Allen-Cahn (A-C) type phase equation with strong nonlinear source term is derived. Using the multiscale Chapman-Enskog analysis, the A-C type phase equation can be recovered from the proposed LB method. Besides, a Lagrange multiplier is introduced based on the mesoscopic character of the LB scheme so that total mass of the hydrocarbon system is preserved. Three-dimensional numerical simulations of realistic hydrocarbon components, such as isobutane and propane, are implemented to illustrate the effectiveness of the proposed mass conservative LB scheme. Numerical results reach a better agreement with laboratory data compared to previous results of two-dimensional numerical simulations.
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http://dx.doi.org/10.1103/PhysRevE.98.023306DOI Listing
August 2018

Analysis of backscattering characteristics of objects for remote laser voice acquisition.

Appl Opt 2014 Feb;53(5):971-8

This study is focused on numerical simulation analysis and experimental study regarding the influence of backscattering characteristics of objects for long-range laser voice acquisition. Based on theoretical analysis, three parameters, including surface roughness of an object, incident angle, and refractive index, which will influence the performance of remote scattered reflection laser interference voice acquisition, are investigated and analyzed. After analysis and simulation, an experimental system is set up to demonstrate the influence of backscattering characteristics of an object. The results show that the restored amplitude of a voice signal decreases gradually, corresponding to an increase of surface roughness from 0.4 to 12.5 μm; the incident angle of the measured laser shall reside between 57.32 deg (1 rad) and -57.32  deg (-1  rad); the optimal incident angle is 0 deg for all kinds of objects; and the metal object is a better choice of material selection. In addition, the restored amplitude of a voice signal rises with the attenuation coefficient of metal increasing. It also increases with the refractive index for a nonmetallic object. Comparing a metal to a nonmetallic object, the amplitude of voice signal varies significantly.
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http://dx.doi.org/10.1364/AO.53.000971DOI Listing
February 2014

Three rhodamine-based "off-on" chemosensors with high selectivity and sensitivity for Fe3+ imaging in living cells.

J Org Chem 2012 Jan 29;77(2):1143-7. Epub 2011 Dec 29.

Ministry of Education Key Laboratory of Synthetic and Natural Functional Molecule Chemistry, College of Chemistry & Materials Science, Northwest University, Xi'an, Shaanxi 710069, PR China.

Three new rhodamine-based probes Y1-Y3 were synthesized as "off-on" chemosensors for Fe(3+) imaging in living cells. The recognizing behaviors were investigated both experimentally and computationally. The crystal structure of the complex Y3-Fe(3+) revealed that Fe(3+) preferred to coordinate with the N atom of benzothiazole moiety rather than the O atom of carboxyl group.
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http://dx.doi.org/10.1021/jo202056tDOI Listing
January 2012