Publications by authors named "Yutao Hua"

4 Publications

  • Page 1 of 1

Phosphorus doped nickel selenide for full device water splitting.

J Colloid Interface Sci 2021 Nov 10;602:115-122. Epub 2021 Jun 10.

School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, China. Electronic address:

The lack of high active and stable electrocatalysts has impeded the development of electrochemical water splitting device, which is promising technique for renewable energy conversion system. Here, we report a one-step protocol to synthesize P doped NiSe (P-NiSe) by selenylation process derived from nickel foam with assistant of NaHPO and Se powder. The P-NiSe could be directly used as working electrode and shows the superior electrochemical activity, offering current density of 10 mA cm with overpotential of 270 mV for OER and 71 mV for HER. The enhanced electrochemical activity can be ascribed to the P atom doping. The P atom doping leads to the high valence state of Ni active sites, which have high catalytic ability towards OER. Moreover, the P doping makes the d-band center of Ni atoms in P-NiSe move close to Fermi level, facilitating the HER kinetics with respect to proton adsorption and hydrogen desorption. When employed P-NiSe as both anodic and cathodic electrode in alkaline water electrolyzer, a current density of 10 mA cm can be achieved at 1.58 V. Our work highlights the importance of P doping in determining the surface electron configuration for full device water splitting and the facile synthesis protocol would be promising for realistic applications.
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http://dx.doi.org/10.1016/j.jcis.2021.06.013DOI Listing
November 2021

Convalescent plasma-mediated resolution of COVID-19 in a patient with humoral immunodeficiency.

Cell Rep Med 2021 Jan 5;2(1):100164. Epub 2020 Dec 5.

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Convalescent plasma (CP) is widely used to treat COVID-19, but without formal evidence of efficacy. Here, we report the beneficial effects of CP in a severely ill COVID-19 patient with prolonged pneumonia and advanced chronic lymphocytic leukemia (CLL), who was unable to generate an antiviral antibody response of her own. On day 33 after becoming symptomatic, the patient received CP containing high-titer (ID > 5,000) neutralizing antibodies (NAbs), defervesced, and improved clinically within 48 h and was discharged on day 37. Hence, when present in sufficient quantities, NAbs to SARS-CoV-2 have clinical benefit even if administered relatively late in the disease course. However, analysis of additional CP units revealed widely varying NAb titers, with many recipients exhibiting endogenous NAb responses far exceeding those of the administered units. To obtain the full therapeutic benefits of CP immunotherapy, it will thus be important to determine the neutralizing activity in both CP units and transfusion candidates.
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http://dx.doi.org/10.1016/j.xcrm.2020.100164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817775PMC
January 2021

[Effects of H2O2 addition on cell growth and product formation in long-chain dicarboxylic acid fermentation].

Wei Sheng Wu Xue Bao 2002 Jun;42(3):359-63

Department of Chemical Engineering, Institute of Biochemical Engineering, Tsinghua University, Beijing 100084, China.

When Candida tropicalis was cultivated in shakig-flask with the H2O2 addition, DCA (Dicarboxylic Acid, DCA) concentration was increased, especially at 2 mmol/L H2O2 concentration. The cytochrome P450 activity assays indicated that H2O2 addition significantly increased the activities of cytochrome P450 and DCA production positively correlated with the activities of cytochrome P450. The study on the cell growth demonstrated that the H2O2 addition inhibited the cell growth rate. However, the retarding effect was not irreversible since the cell growth rate could recover slowly to the original level after the H2O2 addition was halted. The mechanism of inducement on cytochrome P450 by H2O2 addition was also discussed in this article.
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June 2002

Isolation and enzyme determination of Candida tropicalis mutants for DCA production.

J Gen Appl Microbiol 2000 Oct;46(5):245-249

Biochemical Engineering Institute, Department of Chemical Engineering, Tsinghua University, Beijing, 100084, P.R. China.

Techniques, named two-step enrichment and double-time replica-plating method (TEDR), are described that allow a mutated population of Candida tropicalis to be enriched efficiently for mutants deficient in the alkane degradation pathway (Alk(-)) and to be selected easily for mutants increasing in the DCA (dicarboxylic acids) excretion pathway. After C. tropicalis was mutated with ethyl methane sulphonate and ultraviolet, the Alk(-) mutants were enriched (the first step enrichment, up to eightfold in one round of enrichment) by treatment with nystatin in medium SEL1-1. The mutagen-treated cells were then cultured in medium YPD containing chlorpromazine for further enriching (the second-step enrichment, up to threefold in one round) the mutants with an increasing capacity of alpha- and omega-oxidation. On the other hand, the Alk(-) mutants were readily isolated by the SEL1 replica-plating method by using alkane or glucose as the sole carbon source. A total of 43 Alk(-) mutants were isolated from 2x10(8) mutagen-treated cells. In the following steps, by using SEL2 replica plating, the screening studies showed that of the 43 Alk(-) mutants, 11 strains could accumulate DCA greatly from alkane, and strains 1-12 and 1-3, especially, could produce nearly three times as much DCA as the wild-type organism could. The results showed that the strains had more cytochrome P450 activity and a higher converting capacity of alkane.
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http://dx.doi.org/10.2323/jgam.46.245DOI Listing
October 2000
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