Yuri Pekarsky

Yuri Pekarsky

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Yuri Pekarsky

Yuri Pekarsky

Publications by authors named "Yuri Pekarsky"

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Dysregulation of different classes of tRNA fragments in chronic lymphocytic leukemia.

Proc Natl Acad Sci U S A 2019 Nov 13;116(48):24252-24258. Epub 2019 Nov 13.

Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH 43210;

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http://dx.doi.org/10.1073/pnas.1913695116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883801PMC
November 2019

Noncoding RNA genes in cancer pathogenesis.

Adv Biol Regul 2019 01 13;71:219-223. Epub 2018 Dec 13.

Department of Cancer Biology and Genetics, The Wexner Medical Center, Columbus, OH, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22124926183016
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http://dx.doi.org/10.1016/j.jbior.2018.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800108PMC
January 2019

Role of the tRNA-Derived Small RNAs in Cancer: New Potential Biomarkers and Target for Therapy.

Adv Cancer Res 2017 10;135:173-187. Epub 2017 Aug 10.

Wexner Medical Center, The Ohio State University, Columbus, OH, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.acr.2017.06.007DOI Listing
June 2018

BCL2 and miR-15/16: from gene discovery to treatment.

Cell Death Differ 2018 01 6;25(1):21-26. Epub 2017 Oct 6.

Department of Cancer Biology and Genetics, The Wexner Medical Center, Columbus, OH, USA.

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http://dx.doi.org/10.1038/cdd.2017.159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729525PMC
January 2018

BCL2 and miR-15/16: from gene discovery to treatment.

Cell Death Differ 2018 Jan 6;25(1):21-26. Epub 2017 Oct 6.

Department of Cancer Biology and Genetics, The Wexner Medical Center, Columbus, OH, USA.

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http://dx.doi.org/10.1038/cdd.2017.159DOI Listing
January 2018

dysregulation to identify therapeutic target combinations for chronic lymphocytic leukemia.

Proc Natl Acad Sci U S A 2017 10 18;114(40):10731-10736. Epub 2017 Sep 18.

Department of Cancer Biology and Medical Genetics, The Ohio State University, Columbus, OH 43210;

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http://dx.doi.org/10.1073/pnas.1708264114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635897PMC
October 2017

Dysregulation of a family of short noncoding RNAs, tsRNAs, in human cancer.

Proc Natl Acad Sci U S A 2016 May 11;113(18):5071-6. Epub 2016 Apr 11.

Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210; Ohio State University Comprehensive Cancer Center, Columbus, OH 43210;

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http://www.pnas.org/content/113/18/5071.full.pdf
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http://dx.doi.org/10.1073/pnas.1604266113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983805PMC
May 2016

Translocation t(2;11) in CLL cells results in CXCR4/MAML2 fusion oncogene.

Blood 2014 Jul 22;124(2):259-62. Epub 2014 May 22.

Departments of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center and Medicine, The Ohio State University, Columbus, OH; and.

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http://dx.doi.org/10.1182/blood-2014-02-554675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4093682PMC
July 2014

B-cell malignancies in microRNA Eμ-miR-17~92 transgenic mice.

Proc Natl Acad Sci U S A 2013 Nov 21;110(45):18208-13. Epub 2013 Oct 21.

Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Wexner Medical Center, Columbus, OH 43210.

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http://dx.doi.org/10.1073/pnas.1315365110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831438PMC
November 2013

A Sleeping Beauty screen reveals NF-kB activation in CLL mouse model.

Blood 2013 May 16;121(21):4355-8. Epub 2013 Apr 16.

Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1182/blood-2013-02-486035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663428PMC
May 2013

Novel insights in molecular mechanisms of CLL.

Curr Pharm Des 2012 ;18(23):3363-72

Human Cancer Genetics Program and Department of Molecular Virology, Immunology and Medical Genetics, OSU School of Medicine, Ohio State University, Columbus, USA.

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http://dx.doi.org/10.2174/138161212801227104DOI Listing
December 2012

Tcl1 protein functions as an inhibitor of de novo DNA methylation in B-cell chronic lymphocytic leukemia (CLL).

Proc Natl Acad Sci U S A 2012 Feb 30;109(7):2555-60. Epub 2012 Jan 30.

Human Cancer Genetics Program and Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University School of Medicine, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1073/pnas.1200003109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289317PMC
February 2012

NOTCH1 mutations in CLL associated with trisomy 12.

Blood 2012 Jan 15;119(2):329-31. Epub 2011 Nov 15.

Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, USA.

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http://dx.doi.org/10.1182/blood-2011-10-386144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257004PMC
January 2012

IRF4 mutations in chronic lymphocytic leukemia.

Blood 2011 Sep 25;118(10):2827-9. Epub 2011 Jul 25.

Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1182/blood-2011-04-350579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172799PMC
September 2011

Common fragile site tumor suppressor genes and corresponding mouse models of cancer.

J Biomed Biotechnol 2011 29;2011:984505. Epub 2010 Dec 29.

Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1155/2011/984505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035048PMC
June 2011

Mutated beta-catenin evades a microRNA-dependent regulatory loop.

Proc Natl Acad Sci U S A 2011 Mar 7;108(12):4840-5. Epub 2011 Mar 7.

Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1073/pnas.1101734108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064338PMC
March 2011

Molecular basis of CLL.

Semin Cancer Biol 2010 Dec 21;20(6):370-6. Epub 2010 Sep 21.

Human Cancer Genetics Program and Department of Molecular Virology, Immunology and Medical Genetics, OSU School of Medicine, Ohio State University, Columbus, OH 43210, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S1044579X100008
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http://dx.doi.org/10.1016/j.semcancer.2010.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997849PMC
December 2010

Chronic lymphocytic leukemia modeled in mouse by targeted miR-29 expression.

Proc Natl Acad Sci U S A 2010 Jul 21;107(27):12210-5. Epub 2010 Jun 21.

Department of Molecular Virology, Ohio State University School of Medicine, Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1073/pnas.1007186107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901490PMC
July 2010

Is miR-29 an oncogene or tumor suppressor in CLL?

Oncotarget 2010 Jul;1(3):224-7

Human Cancer Genetics Program and Department of Molecular Virology, Immunology and Medical Genetics, OSU School of Medicine, Ohio State University, Columbus, Ohio.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951328PMC
http://dx.doi.org/10.18632/oncotarget.129DOI Listing
July 2010

13q14 deletions in CLL involve cooperating tumor suppressors.

Blood 2010 May 13;115(19):3916-22. Epub 2010 Jan 13.

Human Cancer Genetics Program and Comprehensive Cancer Center, Department of Molecular Virology, Immunology and Medical Genetics, School of Medicine, Ohio State University, Columbus, OH, USA

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http://dx.doi.org/10.1182/blood-2009-10-249367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869560PMC
May 2010

MicroRNAs in mouse models of lymphoid malignancies.

J Nucleic Acids Investig 2010 ;1(1):36-40

Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, Columbus, OH.

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http://dx.doi.org/10.4081/jnai.2010.e8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111058PMC
January 2010

Tcl1 functions as a transcriptional regulator and is directly involved in the pathogenesis of CLL.

Proc Natl Acad Sci U S A 2008 Dec 8;105(50):19643-8. Epub 2008 Dec 8.

Human Cancer Genetics Program, Comprehensive Cancer Center, Department of Molecular Virology, Immunology, and Medical Genetics, School of Medicine, Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1073/pnas.0810965105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604915PMC
December 2008

The role of microRNA and other non-coding RNA in the pathogenesis of chronic lymphocytic leukemia.

Best Pract Res Clin Haematol 2007 Sep;20(3):425-37

Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, Wiseman Hall Room 385K, 400 12th Avenue, Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1016/j.beha.2007.02.003DOI Listing
September 2007

Animal models for chronic lymphocytic leukemia.

J Cell Biochem 2007 Apr;100(5):1109-18

Comprehensive Cancer Center, Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, OSU School of Medicine, Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1002/jcb.21147DOI Listing
April 2007

Targeted deletion of Wwox reveals a tumor suppressor function.

Proc Natl Acad Sci U S A 2007 Mar 27;104(10):3949-54. Epub 2007 Feb 27.

Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, Ohio State University, 410 West 12th Avenue, Columbus, OH 43210, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0609783104
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http://dx.doi.org/10.1073/pnas.0609783104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1820689PMC
March 2007

FHIT-proteasome degradation caused by mitogenic stimulation of the EGF receptor family in cancer cells.

Proc Natl Acad Sci U S A 2006 Dec 1;103(50):18981-6. Epub 2006 Dec 1.

Molecular Biology Unit, Department of Experimental Oncology, Istituto Nazionale Tumori, via Venezian 1, 20133 Milan, Italy.

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http://dx.doi.org/10.1073/pnas.0605821103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1679754PMC
December 2006

Physical association with WWOX suppresses c-Jun transcriptional activity.

Cancer Res 2006 Dec;66(24):11585-9

Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-3376DOI Listing
December 2006

Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181.

Cancer Res 2006 Dec;66(24):11590-3

Comprehensive Cancer Center, Human Cancer Genetics Program and Department of Molecular Virology, Immunology, and Medical Genetics, OSU School of Medicine, Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-3613DOI Listing
December 2006

Biological functions of mammalian Nit1, the counterpart of the invertebrate NitFhit Rosetta stone protein, a possible tumor suppressor.

J Biol Chem 2006 Sep 24;281(38):28244-53. Epub 2006 Jul 24.

Comprehensive Cancer Center and Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, 43210, USA.

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http://dx.doi.org/10.1074/jbc.M603590200DOI Listing
September 2006

Tal1 transgenic expression reveals absence of B lymphocytes.

Cancer Res 2006 Jun;66(12):6014-7

Comprehensive Cancer Center, Human Cancer Genetics Program, OSU School of Medicine, Ohio State University, Columbus, Ohio 43210, USA.

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http://cancerres.aacrjournals.org/content/66/12/6014.full.pd
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-06-0937DOI Listing
June 2006

Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice.

Proc Natl Acad Sci U S A 2006 May 25;103(18):7024-9. Epub 2006 Apr 25.

Comprehensive Cancer Center, Ohio State University, 400 West 12th Avenue, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1073/pnas.0602266103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459012PMC
May 2006

A mouse model of the fragile gene FHIT: From carcinogenesis to gene therapy and cancer prevention.

Mutat Res 2005 Dec 8;591(1-2):103-9. Epub 2005 Aug 8.

Comprehensive Cancer Center, Ohio State University, 400 W. 12th Avenue, Columbus, OH, USA.

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http://dx.doi.org/10.1016/j.mrfmmm.2005.05.016DOI Listing
December 2005

Akt phosphorylates and regulates Pdcd4 tumor suppressor protein.

Cancer Res 2005 Dec;65(24):11282-6

Comprehensive Cancer Center, Human Cancer Genetics Program, and Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University School of Medicine, Columbus, 43210, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-3469DOI Listing
December 2005

WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function.

Cancer Res 2005 Aug;65(15):6764-72

Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43220, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-1150DOI Listing
August 2005

Akt phosphorylates Tal1 oncoprotein and inhibits its repressor activity.

Cancer Res 2005 Jun;65(11):4515-9

Human Cancer Genetics Program, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-0751DOI Listing
June 2005

Phosphorylation of the human Fhit tumor suppressor on tyrosine 114 in Escherichia coli and unexpected steady state kinetics of the phosphorylated forms.

Biochemistry 2005 Apr;44(16):6286-92

Department of Biochemistry, University of Texas Health Science Center, San Antonio, Texas 78229-3900, USA.

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http://dx.doi.org/10.1021/bi047670sDOI Listing
April 2005

Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor.

Cancer Res 2004 Nov;64(22):8256-61

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-2055DOI Listing
November 2004

Tcl1 as a model for lymphomagenesis.

Hematol Oncol Clin North Am 2004 Aug;18(4):863-79, ix

Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, BLSB 1050, Philadelphia, PA 19107, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S088985880400041
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http://dx.doi.org/10.1016/j.hoc.2004.04.007DOI Listing
August 2004

Loss of WWOX expression in gastric carcinoma.

Clin Cancer Res 2004 May;10(9):3053-8

Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1158/1078-0432.ccr-03-0594DOI Listing
May 2004

Fhit is a physiological target of the protein kinase Src.

Proc Natl Acad Sci U S A 2004 Mar 8;101(11):3775-9. Epub 2004 Mar 8.

Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1073/pnas.0400481101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC374320PMC
March 2004

FHIT as tumor suppressor: mechanisms and therapeutic opportunities.

Cancer Biol Ther 2002 May-Jun;1(3):232-6

Kimmel Cancer Center; Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.4161/cbt.73DOI Listing
October 2003

Targeting mature T cell leukemia: new understanding of molecular pathways.

Am J Pharmacogenomics 2003 ;3(1):31-6

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.2165/00129785-200303010-00005DOI Listing
September 2003

FHIT: from gene discovery to cancer treatment and prevention.

Lancet Oncol 2002 Dec;3(12):748-54

Kimmel Cancer Center, Thomas Jefferson University, PA 19107, USA.

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http://dx.doi.org/10.1016/s1470-2045(02)00931-2DOI Listing
December 2002