Yunsun Nam

Yunsun Nam

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Yunsun Nam

Yunsun Nam

Publications by authors named "Yunsun Nam"

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Cryo-EM Structures of Human Drosha and DGCR8 in Complex with Primary MicroRNA.

Mol Cell 2020 Mar 21. Epub 2020 Mar 21.

Laboratory of RNA Biology, Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Departments of Biophysics and Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2020.02.016DOI Listing
March 2020

RNA Specificity and Autoregulation of DDX17, a Modulator of MicroRNA Biogenesis.

Cell Rep 2019 Dec;29(12):4024-4035.e5

Cecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Reproductive Biology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.11.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953907PMC
December 2019

Manipulation by Methylation: Garnishing mRNAs with mAm.

Mol Cell 2019 08;75(3):417-418

Cecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.07.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6860360PMC
August 2019

Structural Basis for Regulation of METTL16, an S-Adenosylmethionine Homeostasis Factor.

Mol Cell 2018 09 6;71(6):1001-1011.e4. Epub 2018 Sep 6.

Cecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765183059
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http://dx.doi.org/10.1016/j.molcel.2018.07.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367934PMC
September 2018

Publisher Correction: Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs.

Nat Commun 2018 09 18;9(1):3852. Epub 2018 Sep 18.

Cecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.

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http://dx.doi.org/10.1038/s41467-018-06426-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143526PMC
September 2018

Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28.

Cell Rep 2018 06;23(10):3091-3101

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA; Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.04.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511231PMC
June 2018

Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs.

Nat Commun 2017 11 23;8(1):1737. Epub 2017 Nov 23.

Cecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.

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http://dx.doi.org/10.1038/s41467-017-01713-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700927PMC
November 2017

LIN28 Zinc Knuckle Domain Is Required and Sufficient to Induce let-7 Oligouridylation.

Cell Rep 2017 03;18(11):2664-2675

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.02.044DOI Listing
March 2017

HP1BP3, a Chromatin Retention Factor for Co-transcriptional MicroRNA Processing.

Mol Cell 2016 08 14;63(3):420-32. Epub 2016 Jul 14.

Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; International Institute for Integrated Sleep Medicine, University of Tsukuba, Tsukuba 305-8575, Japan; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.06.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975613PMC
August 2016

Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.

Mol Cell 2016 07 30;63(2):306-317. Epub 2016 Jun 30.

Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.05.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958592PMC
July 2016

A grid-enabled web service for low-resolution crystal structure refinement.

Acta Crystallogr D Biol Crystallogr 2012 Mar 14;68(Pt 3):261-7. Epub 2012 Feb 14.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1107/S0907444912001163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282622PMC
March 2012

Conformational locking upon cooperative assembly of notch transcription complexes.

Structure 2012 Feb;20(2):340-9

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.str.2011.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285698PMC
February 2012

Molecular basis for interaction of let-7 microRNAs with Lin28.

Cell 2011 Nov 10;147(5):1080-91. Epub 2011 Nov 10.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cell.2011.10.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277843PMC
November 2011

Structure of human O-GlcNAc transferase and its complex with a peptide substrate.

Nature 2011 Jan 16;469(7331):564-7. Epub 2011 Jan 16.

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1038/nature09638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064491PMC
January 2011

Structure of a complex of the ATPase SecA and the protein-translocation channel.

Nature 2008 Oct;455(7215):936-43

Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature07335DOI Listing
October 2008

A role for the two-helix finger of the SecA ATPase in protein translocation.

Nature 2008 Oct;455(7215):984-7

Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA.

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http://www.nature.com/articles/nature07439
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http://dx.doi.org/10.1038/nature07439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354775PMC
October 2008

Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription.

Proc Natl Acad Sci U S A 2007 Feb 6;104(7):2103-8. Epub 2007 Feb 6.

Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0611092104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892977PMC
February 2007

Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1.

Mol Cell Biol 2006 Aug;26(16):6261-71

Department of Hematology/Oncology, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.02478-05
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http://dx.doi.org/10.1128/MCB.02478-05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592797PMC
August 2006

Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.

Cell 2006 Mar;124(5):973-83

Biological and Biomedical Sciences Graduate Program in the Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cell.2005.12.037DOI Listing
March 2006

Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex.

J Biol Chem 2003 Jun 18;278(23):21232-9. Epub 2003 Mar 18.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M301567200
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http://dx.doi.org/10.1074/jbc.M301567200DOI Listing
June 2003

Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling.

Mol Cell Biol 2003 Jan;23(2):655-64

Departments of Pathology, Brigham and Women's Hospital, Harvard Medical School. Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151540PMC
http://dx.doi.org/10.1128/mcb.23.2.655-664.2003DOI Listing
January 2003

Notch signaling as a therapeutic target.

Curr Opin Chem Biol 2002 Aug;6(4):501-9

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/s1367-5931(02)00346-0DOI Listing
August 2002