Publications by authors named "Yunpeng Wang"

213 Publications

Modafinil rescues repeated morphine-induced synaptic and behavioural impairments via activation of D1R-ERK-CREB pathway in medial prefrontal cortex.

Addict Biol 2021 Oct 14:e13103. Epub 2021 Oct 14.

College of Forensic Science, Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Long-term opioid abuse causes a variety of long-lasting cognitive impairments such as attention, impulsivity and working memory. These cognitive impairments undermine behavioural treatment for drug abuse and lead to poor treatment retention and outcomes. Modafinil is a wake-promoting drug that shows potential in improving attention and memory in humans and animals. However, modafinil's effect on opioid-induced cognitive impairments remains unclear, and the underlying mechanism is poorly understood. This study showed that repeated morphine administration significantly impairs attention, increases impulsivity and reduces motivation to natural rewards in mice. Systemic modafinil treatment at low dose efficiently ameliorates morphine-induced attention dysfunction and improves motivation and working memory in mice. High dose of modafinil has adverse effects on impulsive action and attention. Local infusion of D1R antagonist SCH-23390 reverses the morphine-induced synaptic abnormalities and activation of the D1R-ERK-CREB pathway in medial prefrontal cortex (mPFC). This study demonstrated a protective effect of modafinil in mPFC neurons and offered a therapeutic potential for cognitive deficits in opioid abuse.
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http://dx.doi.org/10.1111/adb.13103DOI Listing
October 2021

CT-based radiomics for differentiating invasive adenocarcinomas from indolent lung adenocarcinomas appearing as ground-glass nodules: Asystematic review.

Eur J Radiol 2021 Sep 17;144:109956. Epub 2021 Sep 17.

Department of Radiology, The Second Affiliated Hospital of Nantong University and Nantong First People's Hospital, Nantong, China. Electronic address:

Purpose: To provide an overview of the available studies investigating the use of computer tomography (CT) radiomics features for differentiating invasive adenocarcinomas (IAC) from indolent lung adenocarcinomas presenting as ground-glass nodules (GGNs), to identify the bias of the studies and to propose directions for future research.

Method: PubMed, Embase, Web of Science Core Collection were searched for relevant studies. The studies differentiating IAC from indolent lung adenocarcinomas appearing as GGNs based on CT radiomics features were included. Basic information, patient information, CT-scanner information, technique information and performance information were extracted for each included study. The quality of each study was assessed using the Radiomic Quality Score (RQS) and the Prediction model Risk of Bias Assessment Tool (PROBAST).

Results: Twenty-eight studies were included with patients ranging from 34 to 794. All of them were retrospective. Patients in three studies were from multiple centers. Most studies segmented regions of interest manually. Pyradiomics and AK software were the most frequently used for features extraction. The number of radiomics features extracted varied from 7 to 10329. Logistic regression was the most frequently chosen model. Entropy was identified as radiomics signature in seven studies. The AUC of included studies ranged from 0.77 to 0.98 in 15 validation sets. The percentage RQS ranged from 3% to 50%. According to PROBAST, the overall risk of bias (ROB) was high in 89.3% (25/28) of included studies, unclear in 7.1% (2/28) of included studies, and low in 3.6% (1/28) of included studies. All studies were low concern regarding the applicability of primary studies to the review question.

Conclusion: CT radiomics-based model is promising and encouraging in differentiating IAC from indolent lung adenocarcinomas, though they require methodological rigor. Well-designed studies are necessary to demonstrate their validity and standardization of methods and results can prompt their use in daily clinical practice.
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http://dx.doi.org/10.1016/j.ejrad.2021.109956DOI Listing
September 2021

Ultrafast, High-Contractile Electrothermal-Driven Liquid Crystal Elastomer Fibers towards Artificial Muscles.

Small 2021 Sep 21:e2103700. Epub 2021 Sep 21.

Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, China.

Liquid crystal elastomer (LCE) fibers are capable of large and reversible deformations, making them an ideal artificial muscle. However, limited to stimulating source and structural design, current LCE fibers have not yet achieved both large contraction ratio and fast contraction rate to perform the intense motion. In this work, electrothermal-responsive liquid metal (LM) containing LCE (LM-LCE) fibers is reported. By introducing flexible liquid metal, LM-LCE fibers retain deformability with a large contraction ratio similar to that of pure LCE fibers and are endowed with electrical responsiveness. Applying precisely controlled electrical stimulation, the contraction ratio and rate of LM-LCE fibers can be programmed by adjusting voltage value and pulse time. Under electrical stimulation at 1.25 V cm , 0.1 s, LM-LCE fibers can produce over 40% contraction ratio at an ultrafast contraction rate of up to 280% s . Furthermore, LM-LCE fibers mimic human triceps muscle and can conduct precise ball shooting. LM-LCE fibers with excellent contraction ratio and rate extend their functionality as artificial muscles to perform intense movements and are expected to enrich the challenging applications of soft robots.
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http://dx.doi.org/10.1002/smll.202103700DOI Listing
September 2021

Transcriptomic investigation of the biochemical function of 7-dehydrocholesterol reductase 1 from the traditional Chinese medicinal plant Anemarrhena asphodeloides Bunge.

Phytochemistry 2021 Sep 17;192:112954. Epub 2021 Sep 17.

Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, PR China. Electronic address:

Anemarrhena asphodeloides Bunge (Liliaceae) is an important Traditional Chinese Medicine herb, which contains up to 6 % total steroidal saponins (timosaponins) and has multiple pharmacological properties. However, the timosaponin biosynthetic pathway has not been extensively investigated. Here we conducted de novo transcriptome sequencing and analysis of A. asphodeloides Bunge and screened for candidate genes involved in the timosaponin biosynthetic pathway. Targeted metabolite analysis showed that timosaponins primarily accumulated in rhizomes, while phytosterols (including cholesterol) were distributed throughout various organs. Most of the identified candidate genes of the timosaponin biosynthetic pathway were also highly expressed in the rhizome, consistent with the results of metabolic analysis. Based on the transcriptome results, two candidate 7-dehydrocholesterol reductase genes were cloned and heterologously expressed in the yeast Saccharomyces cerevisiae. The purified and identified products supported that Aa7DR1 possessed Δ-reduction activity in yeast and therefore may be involved in the timosaponins biosynthetic pathway in A. asphodeloides Bunge. Phylogenetic analysis showed Aa7DR1 belongs to monocotyledonous Δ reductase of phytosterol biosynthesis. These data expand our understanding of timosaponin biosynthesis.
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http://dx.doi.org/10.1016/j.phytochem.2021.112954DOI Listing
September 2021

Effects of chlorination on the nitrosamines formation from two algae species in drinking water source-M. aeruginosa and C. meneghiniana.

Chemosphere 2021 Aug 30;287(Pt 1):132093. Epub 2021 Aug 30.

Xiamen Key Laboratory of Municipal and Industrial Solid Waste Utilization and Pollution Control, College of Civil Engineering, Huaqiao University, Xiamen, Fujian, 361021, PR China. Electronic address:

The effects of chlorine dosage, reaction time, algae concentration, and cell components, including extracellular organic matter (EOM), intracellular organic matter (IOM) and cell debris (CD), were evaluated on the formation of nitrosamines (NAs), including N-Nitrosodimethylamine (NDMA), -Nitrosomethylethylamine (NMEA), N-Nitrosodi-n-propylamine (NDPA), N-nitrosodi-n-butylamine (NDBA), N-Nitrosopyrollidine (NPyr), during the chlorination of Microcystis aeruginosa (M. aeruginosa) and Cyclotella meneghiniana (C. meneghiniana) in drinking water treatment. In addition, the NAs formation from Chlorophyll-a and Microcystin-LR (MC-LR) chlorination was investigated. The results showed that NDMA was the most dominant product of two algae, while only a small yield of NPyr, NMEA and NDBA was generated with NDPA as the least. The nitrosamines formation potential (NAsFP) of M. aeruginosa was positively correlated with the chlorine concentration, while the highest NAsFP of C. meneghiniana was observed at 10 mg/L chlorine. With the increase of reaction time, the NAsFP from C. meneghiniana was higher than M. aeruginosa. The NAs formation enhanced with the increase of cell concentration. Moreover, the impacts of cellular components on the NAsFP followed the order of CD > IOM > EOM and IOM > EOM > CD for M. aeruginosa and C. meneghiniana, respectively. The results indicated that proteins and soluble microbial products (SMPs) were the main cellular components to contribute to NAs formation and IOM was the primary source of NAs precursor for both algae. Chlorination of Chlorophyll-a and MC-LR showed that chlorophyll-a formed only a small yield of NDMA and NDBA, while MC-LR made a more significant contribution to the types of NAs.
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http://dx.doi.org/10.1016/j.chemosphere.2021.132093DOI Listing
August 2021

TNFSF9 promotes metastasis of pancreatic cancer through Wnt/Snail signaling and M2 polarization of macrophages.

Aging (Albany NY) 2021 09 13;13(17):21571-21586. Epub 2021 Sep 13.

Departments of Gastroenterology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Early metastasis of pancreatic cancer (PC) leads to high mortality, and the underlying mechanism of metastasis remains unclear. Tumor necrosis factor superfamily member 9 (TNFSF9) is associated with poor prognosis in PC. Here, we investigated the effect of TNFSF9 on PC proliferation and apoptosis, and focused on the effect of TNFSF9 on PC metastasis and its potential mechanism. We found that TNFSF9 promotes PC metastasis and , and may be partially dependent on the Wnt/Snail signaling pathway. In addition, TNFSF9 also regulates the release of cytokines IL-10 and transforming growth factor-β (TGF-β) in pancreatic cancer cells through Wnt signaling to induce the M2 polarization of macrophages and promote the migration of PC cells. Overall, our study found that TNFSF9 may directly promote PC metastasis or indirectly promote PC metastasis through macrophage M2 polarization. Our study provides a new costimulatory target for the treatment of PC.
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http://dx.doi.org/10.18632/aging.203497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457569PMC
September 2021

Prevention and Treatment of Hardware-Related Infections in Deep Brain Stimulation Surgeries: A Retrospective and Historical Controlled Study.

Front Hum Neurosci 2021 26;15:707816. Epub 2021 Aug 26.

Department of Functional Neurosurgery, Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.

Background: Hardware-related infection in deep brain stimulation (DBS) is one of the most commonly reported complications frequently resulting in the removal of implantable pulse generator (IPG).

Objective: The aim of this study was to establish a useful strategy to better prevent and treat those infections and to improve the preservation rates of IPG.

Methods: We conducted a retrospective and historical controlled study of all adult patients (≥18 years old) who had undergone initial DBS implantation at a single center. All participants were enrolled in the control group (between June 2005 and June 2014) or intervention group (between July 2014 and May 2019) based on their surgery dates. We used the intraoperative irrigation with hydrogen dioxide solution in the intervention group. Based on the dates of diagnosis, patients with hardware-related infection after DBS were enrolled in group A (between June 2005 and June 2014) or group B (between July 2014 and May 2019). IPG-sparing algorithm (Isa) was applied for group B. The early-onset IPG infections of the control and intervention groups were evaluated. The IPG preservation rates in both groups A and B were statistically analyzed.

Results: Six cases of early IPG infection and subsequent IPG removal occurred in the control group, while none occurred after intraoperative usage of the hydrogen dioxide in the intervention group. IPG preservation rate of infected cases in group B was significantly higher than that in group A (70% vs.16%, = 0.004).

Conclusion: The combined application of hydrogen dioxide solution and Isa seems to be an effective strategy to prevent IPG infection.
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http://dx.doi.org/10.3389/fnhum.2021.707816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427065PMC
August 2021

The Deformation Behavior and Bending Emissions of ZnO Microwire Affected by Deformation-Induced Defects and Thermal Tunneling Effect.

Sensors (Basel) 2021 Sep 1;21(17). Epub 2021 Sep 1.

State Key Laboratory of Luminescence and Applications, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, No. 3888 Dongnanhu Road, Changchun 130033, China.

The realization of electrically pumped emitters at micro and nanoscale, especially with flexibility or special shapes is still a goal for prospective fundamental research and application. Herein, zinc oxide (ZnO) microwires were produced to investigate the luminescent properties affected by stress. To exploit the initial stress, room temperature in situ elastic bending stress was applied on the microwires by squeezing between the two approaching electrodes. A novel unrecoverable deformation phenomenon was observed by applying a large enough voltage, resulting in the formation of additional defects at bent regions. The electrical characteristics of the microwire changed with the applied bending deformation due to the introduction of defects by stress. When the injection current exceeded certain values, bright emission was observed at bent regions, ZnO microwires showed illumination at the bent region priority to straight region. The bent emission can be attributed to the effect of thermal tunneling electroluminescence appeared primarily at bent regions. The physical mechanism of the observed thermoluminescence phenomena was analyzed using theoretical simulations. The realization of electrically induced deformation and the related bending emissions in single microwires shows the possibility to fabricate special-shaped light sources and offer a method to develop photoelectronic devices.
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http://dx.doi.org/10.3390/s21175887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434524PMC
September 2021

The Role of Butyric Acid in Treatment Response in Drug-Naïve First Episode Schizophrenia.

Front Psychiatry 2021 23;12:724664. Epub 2021 Aug 23.

Department of Psychiatry, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Butyric acid, a major short-chain fatty acid (SCFA), has an important role in the microbiota-gut-brain axis and brain function. This study investigated the role of butyric acid in treatment response in drug-naïve first episode schizophrenia. The study recruited 56 Chinese Han schizophrenia inpatients with normal body weight and 35 healthy controls. Serum levels of butyric acid were measured using Gas Chromatography-Mass Spectrometer (GC-MS) analysis at baseline (for all participants) and 24 weeks after risperidone treatment (for patients). Clinical symptoms were measured using the Positive and Negative Syndrome Scale (PANSS) for patients at both time points. At baseline, there was no significant difference in serum levels of butyric acid between patients and healthy controls ( = 0.206). However, there was a significant increase in serum levels of butyric acid in schizophrenia patients after 24-week risperidone treatment ( = 0.030). The PANSS total and subscale scores were decreased significantly after 24-week risperidone treatment ( < 0.001). There were positive associations between baseline serum levels of butyric acid and the reduction ratio of the PANSS total and subscale scores after controlling for age, sex, education, and duration of illness ( < 0.05). Further, there was a positive association between the increase in serum levels of butyric acid and the reduction of the PANSS positive symptoms subscale scores ( = 0.38, = 0.019) after controlling for potential confounding factors. Increased serum levels of butyric acid might be associated with a favorable treatment response in drug-naïve, first episode schizophrenia. The clinical implications of our findings were discussed.
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http://dx.doi.org/10.3389/fpsyt.2021.724664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421030PMC
August 2021

Translating polygenic risk scores for clinical use by estimating the confidence bounds of risk prediction.

Nat Commun 2021 09 6;12(1):5276. Epub 2021 Sep 6.

Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark.

A promise of genomics in precision medicine is to provide individualized genetic risk predictions. Polygenic risk scores (PRS), computed by aggregating effects from many genomic variants, have been developed as a useful tool in complex disease research. However, the application of PRS as a tool for predicting an individual's disease susceptibility in a clinical setting is challenging because PRS typically provide a relative measure of risk evaluated at the level of a group of people but not at individual level. Here, we introduce a machine-learning technique, Mondrian Cross-Conformal Prediction (MCCP), to estimate the confidence bounds of PRS-to-disease-risk prediction. MCCP can report disease status conditional probability value for each individual and give a prediction at a desired error level. Moreover, with a user-defined prediction error rate, MCCP can estimate the proportion of sample (coverage) with a correct prediction.
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http://dx.doi.org/10.1038/s41467-021-25014-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421428PMC
September 2021

Education and Income Show Heterogeneous Relationships to Lifespan Brain and Cognitive Differences Across European and US Cohorts.

Cereb Cortex 2021 Aug 31. Epub 2021 Aug 31.

Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin 14195, Germany.

Higher socio-economic status (SES) has been proposed to have facilitating and protective effects on brain and cognition. We ask whether relationships between SES, brain volumes and cognitive ability differ across cohorts, by age and national origin. European and US cohorts covering the lifespan were studied (4-97 years, N = 500 000; 54 000 w/brain imaging). There was substantial heterogeneity across cohorts for all associations. Education was positively related to intracranial (ICV) and total gray matter (GM) volume. Income was related to ICV, but not GM. We did not observe reliable differences in associations as a function of age. SES was more strongly related to brain and cognition in US than European cohorts. Sample representativity varies, and this study cannot identify mechanisms underlying differences in associations across cohorts. Differences in neuroanatomical volumes partially explained SES-cognition relationships. SES was more strongly related to ICV than to GM, implying that SES-cognition relations in adulthood are less likely grounded in neuroprotective effects on GM volume in aging. The relatively stronger SES-ICV associations rather are compatible with SES-brain volume relationships being established early in life, as ICV stabilizes in childhood. The findings underscore that SES has no uniform association with, or impact on, brain and cognition.
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http://dx.doi.org/10.1093/cercor/bhab248DOI Listing
August 2021

Relationships between apparent cortical thickness and working memory across the lifespan - Effects of genetics and socioeconomic status.

Dev Cogn Neurosci 2021 Oct 8;51:100997. Epub 2021 Aug 8.

Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, 0317, Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, 0372, Oslo, Norway. Electronic address:

Working memory (WM) supports several higher-level cognitive abilities, yet we know less about factors associated with development and decline in WM compared to other cognitive processes. Here, we investigated lifespan changes in WM capacity and their structural brain correlates, using a longitudinal sample including 2358 magnetic resonance imaging (MRI) scans and WM scores from 1656 participants (4.4-86.4 years, mean follow-up interval 4.3 years). 8764 participants (9.0-10.9 years) with MRI, WM scores and genetic information from the Adolescent Brain Cognitive Development study were used for follow-up analyses. Results showed that both the information manipulation component and the storage component of WM improved during childhood and adolescence, but the age-decline could be fully explained by reductions in passive storage capacity alone. Greater WM function in development was related to apparent thinner cortex in both samples, also when general cognitive function was accounted for. The same WM-apparent thickness relationship was found for young adults. The WM-thickness relationships could not be explained by SNP-based co-heritability or by socioeconomic status. A larger sample with genetic information may be necessary to disentangle the true gene-environment effects. In conclusion, WM capacity changes greatly through life and has anatomically extended rather than function-specific structural cortical correlates.
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http://dx.doi.org/10.1016/j.dcn.2021.100997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371229PMC
October 2021

Gut microbial biomarkers for the treatment response in first-episode, drug-naïve schizophrenia: a 24-week follow-up study.

Transl Psychiatry 2021 08 10;11(1):422. Epub 2021 Aug 10.

Department of Psychiatry, The First Affiliated Hospital/Zhengzhou University, Zhengzhou, China.

Preclinical studies have shown that the gut microbiota can play a role in schizophrenia (SCH) pathogenesis via the gut-brain axis. However, its role in the antipsychotic treatment response is unclear. Here, we present a 24-week follow-up study to identify gut microbial biomarkers for SCH diagnosis and treatment response, using a sample of 107 first-episode, drug-naïve SCH patients, and 107 healthy controls (HCs). We collected biological samples at baseline (all participants) and follow-up time points after risperidone treatment (SCH patients). Treatment response was assessed using the Positive and Negative Symptoms Scale total (PANSS-T) score. False discovery rate was used to correct for multiple testing. We found that SCH patients showed lower α-diversity (the Shannon and Simpson's indices) compared to HCs at baseline (p = 1.21 × 10, 1.23 × 10, respectively). We also found a significant difference in β-diversity between SCH patients and HCs (p = 0.001). At baseline, using microbes that showed different abundance between patients and controls as predictors, a prediction model can distinguish patients from HCs with an area under the curve (AUC) of 0.867. In SCH patients, after 24 weeks of risperidone treatment, we observed an increase of α-diversity toward the basal level of HCs. At the genus level, we observed decreased abundance of Lachnoclostridium (p = 0.019) and increased abundance Romboutsia (p = 0.067). Moreover, the treatment response in SCH patients was significantly associated with the basal levels of Lachnoclostridium and Romboutsia (p = 0.005 and 0.006, respectively). Our results suggest that SCH patients may present characteristic microbiota, and certain microbiota biomarkers may predict treatment response in this patient population.
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http://dx.doi.org/10.1038/s41398-021-01531-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355081PMC
August 2021

The role of SIRT1 in the basolateral amygdala in depression-like behaviors in mice.

Genes Brain Behav 2021 Aug 5:e12765. Epub 2021 Aug 5.

College of Forensic Science, Xi'an Jiaotong University, Shaanxi, China.

Previous investigations have implicated the basolateral amygdala (BLA) epigenetic mechanisms in the pathophysiology of depression. SIRT1 is a NAD+-dependent class III histone deacetylase, widely expresses in BLA. However, epigenetic mechanisms in the BLA under the regulation of SIRT1 in the depression are largely uncharacterized. Under the chronic unpredictable chronic mild stress (CUMS) mouse model, we used adeno-associated viral vectors (AAV) that encoded SIRT1-shRNA or SIRT1 to specifically knockdown or overexpress SIRT1 in BLA neurons, respectively. CUMS procedure induced significant depression symptoms including the decreased sucrose preference, the less bodyweight gained, the decreased immobile latency and the increased immobile time both in forced swim test (FST) and tail suspension test (TST). Knockdown of SIRT1 in BLA glutamatergic neurons reversed these depression-like behaviors and restored the synaptic abnormalities. Overexpression of SIRT1 in BLA glutamatergic neurons induced depression-like behaviors in non-stressed control mice. The result of protein expressions and ultrastructural changes were consistent with the behavioral results. Our study suggested that downregulation of SIRT1 in BLA has certain beneficial effect on CUMS-induced depression-like behaviors such as anorexia, anhedonia, hopelessness and despair. In addition, the increased expression of SIRT1 may be the immediate cause of depressive-like symptoms. The abnormal expression of SIRT1 may affect the transcriptional regulation mechanism and signaling protein acetylation, affecting neuroplasticity and ultimately contribute to MDD. In the stress-susceptible mice, these two mechanisms may co-exist, but the specific mechanism needs further research.
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http://dx.doi.org/10.1111/gbb.12765DOI Listing
August 2021

Formation of nitrosamines during chloramination of two algae species in source water-Microcystis aeruginosa and Cyclotella meneghiniana.

Sci Total Environ 2021 Dec 22;798:149210. Epub 2021 Jul 22.

Xiamen Key Laboratory of Municipal and Industrial Solid Waste Utilization and Pollution Control, College of Civil Engineering, Huaqiao University, Xiamen, Fujian 361021, PR China. Electronic address:

The contribution of two algae species, Microcystis aeruginosa (M. aeruginosa) and Cyclotella meneghiniana (C. meneghiniana), to the formation of nitrosamines (NAs) during chloramination in drinking water treatment was investigated. A variety of factors including contact time, algae cell concentration, chloramine dosages, and algal cell components (cell debris (CD), intracellular organic matter (IOM), and extracellular organic matter (EOM)) were evaluated for influencing the formation of different NAs, such as N-Nitrosodiethylamine (NDMA), N-Nitrosomethylethylamine (NMEA), N-Nitrosodibutylamine (NDBA), N-Nitrosodi-n-propylamine (NDPA), and N-nitrosopyridine (NPyr). In addition, NAs formation from Chlorophyll-a and Microcystin-LR (MC-LR) after chloramination was studied. These results showed that the increase of reaction time and algae cell concentration enhanced the formation potential of five types of NAs from both algae species, except for the NDMA formation from C. meneghiniana, which increased first and then decreased with increased reaction time. The generation of NDMA was detected as the dominated type of NAs. The formation of total NAs from both algae species followed same pattern of increasing first and then decreasing with the increase of chloramine dosage. The largest NAs formation potential (NAsFP) of M. aeruginosa and C. meneghiniana showed at 1.5 mM and 1.0 mM monochloramine, respectively. Moreover, the impacts of algae cellular components on the formation potential of NAs followed the order of IOM > EOM ≫ CD and IOM ≫ CD > EOM for M. aeruginosa and C. meneghiniana, respectively, indicating that IOM was the main source of NAs precursors for both algae. Furthermore, EEM analysis before and after chloramination confirmed that the soluble microbial products (SMPs) and protein-like substances were the main cellular components that contributed to NAs formation for both algae. The NAs formation potential of Microcystin-LR was much higher than that of Chlorophyll-a chloramination.
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http://dx.doi.org/10.1016/j.scitotenv.2021.149210DOI Listing
December 2021

AbdomenCT-1K: Is Abdominal Organ Segmentation A Solved Problem.

IEEE Trans Pattern Anal Mach Intell 2021 Jul 27;PP. Epub 2021 Jul 27.

With the unprecedented developments in deep learning, automatic segmentation of main abdominal organs seems to be a solved problem as state-of-the-art (SOTA) methods have achieved comparable results with inter-rater variability on many benchmark datasets. However, most of the existing abdominal datasets only contain single-center, single-phase, single-vendor, or single-disease cases, and it is unclear whether the excellent performance can generalize on diverse datasets. This paper presents a large and diverse abdominal CT organ segmentation dataset, termed AbdomenCT-1K, with more than 1000 (1K) CT scans from 12 medical centers, including multi-phase, multi-vendor, and multi-disease cases. Furthermore, we conduct a large-scale study for liver, kidney, spleen, and pancreas segmentation and reveal the unsolved segmentation problems of the SOTA methods, such as the limited generalization ability on distinct medical centers, phases, and unseen diseases. To advance the unsolved problems, we further build four organ segmentation benchmarks for fully supervised, semi-supervised, weakly supervised, and continual learning, which are currently challenging and active research topics. Accordingly, we develop a simple and effective method for each benchmark, which can be used as out-of-the-box methods and strong baselines. We believe the AbdomenCT-1K dataset will promote future in-depth research towards clinical applicable abdominal organ segmentation methods.
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http://dx.doi.org/10.1109/TPAMI.2021.3100536DOI Listing
July 2021

Two-Step Chemical Vapor Deposition-Synthesized Lead-Free All-Inorganic CsSbBr Perovskite Microplates for Optoelectronic Applications.

ACS Appl Mater Interfaces 2021 Aug 21;13(30):35930-35940. Epub 2021 Jul 21.

Department of Physics, City University of Hong Kong, Kowloon, Hong Kong SAR, China.

Lead-based halide perovskites (APbX, where A = organic or inorganic cation, X = Cl, Br, I) are suitable materials for many optoelectronic devices due to their many attractive properties. However, the concern of lead toxicity and the poor ambient and operational stability of the organic cation group greatly limit their practical utilization. Therefore, there has recently been great interest in lead-free, environment-friendly all-inorganic halide perovskites (IHPs). Sb and Sn are common species suggested to replace Pb for Pb-free IHPs. However, the large difference in the melting points of the precursor materials (e.g., CsBr and SbBr precursors for CsSbBr) makes the chemical vapor deposition (CVD) growth of high-quality Pb-free IHPs a very challenging task. In this work, we developed a two-step CVD method to overcome this challenge and successfully synthesized Pb-free CsSbBr perovskite microplates. CsSbBr microplates ∼25 μm in size with the exciton absorption peak at ∼2.8 eV and a band gap of ∼2.85 eV were obtained. The microplates have a smooth hexagonal morphology and show a large Stokes shift of ∼450 meV and exciton binding energy of ∼200 meV. To demonstrate the applications of these microplates in optoelectronics, simple photoconductive devices were fabricated. These photodetectors exhibit a current on/off ratio of 2.36 × 10, a responsivity of 36.9 mA/W, and a detectivity of 1.0 × 10 Jones with a fast response of rise and decay time of 61.5 and 24 ms, respectively, upon 450 nm photon irradiation. Finally, the CsSbBr microplates also show good stability in ambient air without encapsulation. These results demonstrate that the 2-step CVD process is an effective approach to synthesize high-quality all-inorganic lead-free CsSbBr perovskite microplates that have the potential for future high-performance optoelectronic device applications.
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http://dx.doi.org/10.1021/acsami.1c07839DOI Listing
August 2021

The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan.

Elife 2021 06 28;10. Epub 2021 Jun 28.

Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.

Development and aging of the cerebral cortex show similar topographic organization and are governed by the same genes. It is unclear whether the same is true for subcortical regions, which follow fundamentally different ontogenetic and phylogenetic principles. We tested the hypothesis that genetically governed neurodevelopmental processes can be traced throughout life by assessing to which degree brain regions that develop together continue to change together through life. Analyzing over 6000 longitudinal MRIs of the brain, we used graph theory to identify five clusters of coordinated development, indexed as patterns of correlated volumetric change in brain structures. The clusters tended to follow placement along the cranial axis in embryonic brain development, suggesting continuity from prenatal stages, and correlated with cognition. Across independent longitudinal datasets, we demonstrated that developmental clusters were conserved through life. Twin-based genetic correlations revealed distinct sets of genes governing change in each cluster. Single-nucleotide polymorphisms-based analyses of 38,127 cross-sectional MRIs showed a similar pattern of genetic volume-volume correlations. In conclusion, coordination of subcortical change adheres to fundamental principles of lifespan continuity and genetic organization.
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http://dx.doi.org/10.7554/eLife.66466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260220PMC
June 2021

Genetic Association Between Schizophrenia and Cortical Brain Surface Area and Thickness.

JAMA Psychiatry 2021 Sep;78(9):1020-1030

NORMENT, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Importance: Schizophrenia is a complex heritable disorder associated with many genetic variants, each with a small effect. While cortical differences between patients with schizophrenia and healthy controls are consistently reported, the underlying molecular mechanisms remain elusive.

Objective: To investigate the extent of shared genetic architecture between schizophrenia and brain cortical surface area (SA) and thickness (TH) and to identify shared genomic loci.

Design, Setting, And Participants: Independent genome-wide association study data on schizophrenia (Psychiatric Genomics Consortium and CLOZUK: n = 105 318) and SA and TH (UK Biobank: n = 33 735) were obtained. The extent of polygenic overlap was investigated using MiXeR. The specific shared genomic loci were identified by conditional/conjunctional false discovery rate analysis and were further examined in 3 independent cohorts. Data were collected from December 2019 to February 2021, and data analysis was performed from May 2020 to February 2021.

Main Outcomes And Measures: The primary outcomes were estimated fractions of polygenic overlap between schizophrenia, total SA, and average TH and a list of functionally characterized shared genomic loci.

Results: Based on genome-wide association study data from 139 053 participants, MiXeR estimated schizophrenia to be more polygenic (9703 single-nucleotide variants [SNVs]) than total SA (2101 SNVs) and average TH (1363 SNVs). Most SNVs associated with total SA (1966 of 2101 [93.6%]) and average TH (1322 of 1363 [97.0%]) may be associated with the development of schizophrenia. Subsequent conjunctional false discovery rate analysis identified 44 and 23 schizophrenia risk loci shared with total SA and average TH, respectively. The SNV associations of shared loci between schizophrenia and total SA revealed en masse concordant association between the discovery and independent cohorts. After removing high linkage disequilibrium regions, such as the major histocompatibility complex region, the shared loci were enriched in immunologic signature gene sets. Polygenic overlap and shared loci between schizophrenia and schizophrenia-associated regions of interest for SA (superior frontal and middle temporal gyri) and for TH (superior temporal, inferior temporal, and superior frontal gyri) were also identified.

Conclusions And Relevance: This study demonstrated shared genetic loci between cortical morphometry and schizophrenia, among which a subset are associated with immunity. These findings provide an insight into the complex genetic architecture and associated with schizophrenia.
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http://dx.doi.org/10.1001/jamapsychiatry.2021.1435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223140PMC
September 2021

Isolation, Identification, and Anti-Inflammatory Activity of Polysaccharides of .

Biomacromolecules 2021 06 23;22(6):2451-2459. Epub 2021 May 23.

Jiangsu Provincial Key Construction Laboratory of Probiotics Preparation, College of Life Science and Food Engineering, Huaiyin Institute of Technology, Huai'an 223003, China.

The present study aimed to purify, structurally characterize, and evaluate the anti-inflammatory activity of the polysaccharide extracted from . Two purified polysaccharides (PTA-1 and PTA-2) were obtained via DEAE-52 cellulose chromatography. Their structural characterizations and antioxidant activity were in vitro analyzed. To evaluate the anti-inflammatory activity of PTA-2, the levels of inflammatory cytokines, intracellular ROS production, and the inhibitory effects of the transcriptional activation of the nuclear factor kappa B (NF-κB) signaling pathway were determined. PTA-1 comprises glucose (100%) with α-(1 → 3) glycosidic bonds, and PTA-2 comprises glucose (66.7%) and rhamnose (33.3%) formed by β-(1 → 3) glycosidic bonds. PTA-1 and PTA-2 showed strong antioxidant activity in vitro. Moreover, PTA-2 intervention (50, 100, and 200 μg/mL) suppressed the production of inflammatory cytokines, the activation of NF-κB signaling, and reactive oxygen species production significantly. The results identified PTA-2 as a natural product that could be applied in anti-inflammatory drugs.
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http://dx.doi.org/10.1021/acs.biomac.1c00235DOI Listing
June 2021

The changes in miR-221 and miR-222 before and after interventional therapy of coronary heart disease and analysis of their correlation with inflammatory factors and prognosis.

Am J Transl Res 2021 15;13(4):3731-3737. Epub 2021 Apr 15.

Department of Cardiology, The Second People's Hospital of Dongying Dongying, Shandong Province, China.

Objective: To explore the changes in miR-221 and miR-222 before and after interventional therapy of coronary heart disease and their relationship with inflammatory factors and prognosis.

Methods: A total of 122 subjects with coronary heart disease who underwent interventional therapy in our hospital from January 2017 to January 2019 were chosen as the observation group, and 122 healthy people during the same period were chosen as the control group. We retrospectively analyzed the levels of serum miR-221, miR-222, C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6). Pearson correlation analysis was used to reveal the relationship between serum levels of miR-221, miR-222 and CRP, TNF-α and IL-6, N-terminal B-type brain natriuretic peptide precursor (NT-proBNP) and left ventricular ejection fraction (LVEF%) in the observation group. The levels of serum miR-221, miR-222, TNF-α, CRP and IL-6 before and after treatment were compared in the observation group. After a follow-up of 6 months, the observation group was divided into a poor-prognosis group (26 cases) and a good-prognosis group (96 cases) according to whether there was an adverse cardiovascular event or not. The levels of serum miR-221 and miR-222 before and after intervention treatment were compared between the two groups. And the clinical values of miR-221 and miR-222 levels before and after intervention treatment in the observation group were analyzed by the ROC curve.

Results: The levels of serum miR-221, miR-222, CRP, TNF-α, and IL-6 in the observation group were markedly higher than those of the control group. And levels of serum miR-221, miR-222 were negatively correlated with LVEF% while positively correlated with CRP, TNF-α, IL-6 and NT-proBNP (P<0.05). After treatment, the levels of miR-221, miR-222, CRP, TNF-α, and IL-6 in the observation group were significantly reduced (all P<0.05). Compared with the good prognosis group, the levels of miR-221 and miR-222 before and after treatment were markedly higher in the poor prognosis group (all P<0.05). Both before and after treatment, the levels of miR-221 and miR-222 have certain clinical value in evaluating the prognosis (all AUC>0.800).

Conclusion: The levels of miR-221 and miR-222 in patients with coronary heart disease significantly increased and they were closely correlated with the inflammatory factors, NT-proBNP and LVEF%. The levels of miR-221 and miR-222 before and after treatment have certain clinical value in evaluating the prognosis of patients.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129388PMC
April 2021

Effectiveness of Low-Frequency Pallidal Deep Brain Stimulation at 65 Hz in Tourette Syndrome.

Neuromodulation 2021 May 17. Epub 2021 May 17.

Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.

Objectives: Pallidal deep brain stimulation (DBS) for refractory Tourette syndrome (TS) is often applied using a high frequency. The effectiveness of low-frequency long-term stimulation is unknown. We aimed to evaluate the clinical efficacy of low-frequency DBS applied to the globus pallidus pars internus (GPi) at 65 Hz for the treatment of TS, with long-term follow-up, to provide data for the optimization of stimulation parameters.

Materials And Methods: A total of six patients with refractory TS were implanted with electrodes in the GPi and were assigned to receive low-frequency (65 Hz) DBS programming. Assessments were performed pre-DBS and at 3, 12, and a median of 34 (range 26-48) months post-DBS. The primary outcome was tic severity, as assessed by the Yale Global Tic Severity Scale (YGTSS), and the secondary outcomes were comorbid behavioral disorders, mood, functioning, and quality of life.

Results: We noted significant differences in the YGTSS scores between the baseline and the post-DBS follow-ups (p = 0.01). At the final follow up, four of six (66.6%) patients had a greater than 50% reduction in the YGTSS score, whereas the remaining two patients showed a mild worsening of tic severity. The secondary outcome measures also showed remarkable improvements in associated behavioral disorders, mood, functioning, and quality of life. Stimulation-induced adverse effects were not reported, although a device-related complication (an uncomfortable feeling in the neck) occurred in 1 patient.

Conclusions: The results of this study indicated that low-frequency DBS represents an effective and practical treatment for refractory TS with comparable efficacy to high-frequency DBS.
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http://dx.doi.org/10.1111/ner.13456DOI Listing
May 2021

Development and Validation a Nomogram Incorporating CT Radiomics Signatures and Radiological Features for Differentiating Invasive Adenocarcinoma From Adenocarcinoma and Minimally Invasive Adenocarcinoma Presenting as Ground-Glass Nodules Measuring 5-10mm in Diameter.

Front Oncol 2021 21;11:618677. Epub 2021 Apr 21.

Shanghai Public Health Clinical Center and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.

Purpose: To develop and validate a nomogram for differentiating invasive adenocarcinoma (IAC) from adenocarcinoma (AIS) and minimally invasive adenocarcinoma (MIA) presenting as ground-glass nodules (GGNs) measuring 5-10mm in diameter.

Materials And Methods: This retrospective study included 446 patients with 478 GGNs histopathologically confirmed AIS, MIA or IAC. These patients were assigned to a primary cohort, an internal validation cohort and an external validation cohort. The segmentation of these GGNs on thin-slice computed tomography (CT) were performed semi-automatically with in-house software. Radiomics features were then extracted from unenhanced CT images with PyRadiomics. Radiological features of these GGNs were also collected. Radiomics features were investigated for usefulness in building radiomics signatures by spearman correlation analysis, minimum redundancy maximum relevance (mRMR) feature ranking method and least absolute shrinkage and selection operator (LASSO) classifier. Multivariable logistic regression analysis was used to develop a nomogram incorporating the radiomics signature and radiological features. The performance of the nomogram was assessed with discrimination, calibration, clinical usefulness and evaluated on the validation cohorts.

Results: Five radiomics features remained after features selection. The model incorporating radiomics signatures and four radiological features (bubble-like appearance, tumor-lung interface, mean CT value, average diameter) showed good calibration and good discrimination with AUC of 0.831(95%CI, 0.772~0.890). Application of the nomogram in the internal validation cohort with AUC of 0.792 (95%CI, 0.712~0.871) and in the external validation cohort with AUC of 0.833 (95%CI, 0.729-0.938) also indicated good calibration and good discrimination. The decision curve analysis demonstrated that the nomogram was clinically useful.

Conclusion: This study presents a nomogram incorporating the radiomics signatures and radiological features, which can be used to predict the risk of IAC in patients with GGNs measuring 5-10mm in diameter individually.
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http://dx.doi.org/10.3389/fonc.2021.618677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096901PMC
April 2021

Self-Reported Sleep Relates to Microstructural Hippocampal Decline in β-Amyloid Positive Adults Beyond Genetic Risk.

Sleep 2021 Apr 27. Epub 2021 Apr 27.

Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, 0317 Oslo, Norway.

Study Objectives: A critical role linking sleep with memory decay and β-amyloid (Aβ) accumulation, two markers of Alzheimer's disease (AD) pathology, may be played by hippocampal integrity. We tested the hypotheses that worse self-reported sleep relates to decline in memory and intra-hippocampal microstructure, including in the presence of Aβ.

Methods: Two-hundred and forty-three cognitively healthy participants, aged 19-81 years, completed the Pittsburgh Sleep Quality Index once, and 2 diffusion tensor imaging sessions, on average 3 years apart, allowing measures of decline in intra-hippocampal microstructure as indexed by increased mean diffusivity. We measured memory decay at each imaging session using verbal delayed recall. One session of positron emission tomography, in 108 participants above 44 years of age, yielded 23 Aβ positive. Genotyping enabled control for APOE ε4 status, and polygenic scores for sleep and AD, respectively.

Results: Worse global sleep quality and sleep efficiency related to more rapid reduction of hippocampal microstructure over time. Focusing on efficiency (the percentage of time in bed at night spent asleep), the relation was stronger in presence of Aβ accumulation, and hippocampal integrity decline mediated the relation with memory decay. The results were not explained by genetic risk for sleep efficiency or AD.

Conclusions: Worse sleep efficiency related to decline in hippocampal microstructure, especially in the presence of Aβ accumulation, and Aβ might link poor sleep and memory decay. As genetic risk did not account for the associations, poor sleep efficiency might constitute a risk marker for AD, although the driving causal mechanisms remain unknown.
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http://dx.doi.org/10.1093/sleep/zsab110DOI Listing
April 2021

Effects of endplate healing morphology on intervertebral disc degeneration after pedicle screw fixation for thoracolumbar fractures.

Medicine (Baltimore) 2021 Apr;100(17):e25636

Orthopaedic Trauma Service Center, The Third Hospital of Hebei Medical University, Major Laboratory of Orthopaedic Biomechanics in Hebei Province.

Abstract: The cartilage endplate plays an important role in the stress distribution and nutrition metabolism of the intervertebral disc. The healing morphology of the endplate after spinal fracture and its effect on the intervertebral disc degeneration are still unclear.This was a retrospective study. Patients with traumatic single-level thoracolumbar fractures treated in our orthopedic trauma service center from June 2011 to May 2019 were included and the relevant data were collected from the medical records. Based on combined computed tomography and MRI images, the endplate injury status was determined (no endplate injury, unilateral and bilateral endplate injury). According to the location of the injury, endplate injury was further divided into endplate central injury and endplate peripheral injury. The degree of posttraumatic disc lesions and disc degeneration during follow-up were classified based on the Sander classification and the Pfirrmann classification, respectively. According to the T1 image of MRI at the final follow-up, the healing morphology of endplates was determined and classified. Univariate analyses and correlation analyses were performed to evaluate the within- and between-group differences.There were in total 51 patients included in this study. Cartilage endplate fracture was significantly closely related to the degree of degeneration of the intervertebral disc (P = .003). Injuries in different parts of the endplate have no significant effect on the intervertebral disc degeneration (P = .204). The healing morphology after endplate fracture significantly affected the degree of intervertebral disc degeneration (P = .001). The comparisons of groups showed that the effects of irregular healing and traumatic Schmorl nodes on disc degeneration were not statistically significant, but were significantly significant with increased curvature.These results suggest that the irregular healing and the traumatic Schmorl nodes are closely related to intervertebral disc degeneration. The presence and severity of the endplate injury can provide valuable information for individualized clinical decision-making processes.
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http://dx.doi.org/10.1097/MD.0000000000025636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084067PMC
April 2021

Acute lymphocytic leukemia with initial manifestation of serous retinal detachment and choroidal thickening: case report and literature review.

J Int Med Res 2021 Mar;49(3):300060520964373

Department of Ophthalmology, The 900th Hospital of Joint Logistic Support Force, PLA (Clinical Medical College of Fujian Medical University, Dongfang Hopsital Affiliated to Xiamen University), Fuzhou, China.

This report describes a patient who had acute lymphocytic leukemia with exudative retinal detachment (RD), which mimicked Vogt-Koyanagi-Harada disease (VKH). A 61-year-old woman presented with painless loss of vision in the left eye. Fundus examination revealed RD in her left eye. B-scan ultrasonography confirmed localized RD and choroidal thickening. Fundus fluorescein angiography revealed stippled pinpoint hyperfluorescence in the upper macula. One week later, reduced visual acuity was noted in the right eye. B-scan ultrasonography and optical coherence tomography revealed serous RD in both eyes. A provisional diagnosis of VKH was made. However, subsequent hematologic analysis detected an extremely high leukocyte count. Elevated numbers of leukocytes and tumor cells were found in cerebrospinal fluid. Bone marrow biopsy revealed 77% primary atypical blood cells, 89% of which were immature lymphocytes. The patient was subsequently diagnosed with acute lymphocytic leukemia and transferred to the Department of Hematology. However, the patient and her family refused chemotherapy; she eventually died. Our findings suggest that exudative RD, similar to VKH, could be a sign of leukemia. Pinpoint hyperfluorescence leakage is important for differential diagnosis, particularly with respect to VKH.
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http://dx.doi.org/10.1177/0300060520964373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166396PMC
March 2021

Acute lymphocytic leukemia with initial manifestation of serous retinal detachment and choroidal thickening: case report and literature review.

J Int Med Res 2021 Mar;49(3):300060520964373

Department of Ophthalmology, The 900th Hospital of Joint Logistic Support Force, PLA (Clinical Medical College of Fujian Medical University, Dongfang Hopsital Affiliated to Xiamen University), Fuzhou, China.

This report describes a patient who had acute lymphocytic leukemia with exudative retinal detachment (RD), which mimicked Vogt-Koyanagi-Harada disease (VKH). A 61-year-old woman presented with painless loss of vision in the left eye. Fundus examination revealed RD in her left eye. B-scan ultrasonography confirmed localized RD and choroidal thickening. Fundus fluorescein angiography revealed stippled pinpoint hyperfluorescence in the upper macula. One week later, reduced visual acuity was noted in the right eye. B-scan ultrasonography and optical coherence tomography revealed serous RD in both eyes. A provisional diagnosis of VKH was made. However, subsequent hematologic analysis detected an extremely high leukocyte count. Elevated numbers of leukocytes and tumor cells were found in cerebrospinal fluid. Bone marrow biopsy revealed 77% primary atypical blood cells, 89% of which were immature lymphocytes. The patient was subsequently diagnosed with acute lymphocytic leukemia and transferred to the Department of Hematology. However, the patient and her family refused chemotherapy; she eventually died. Our findings suggest that exudative RD, similar to VKH, could be a sign of leukemia. Pinpoint hyperfluorescence leakage is important for differential diagnosis, particularly with respect to VKH.
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http://dx.doi.org/10.1177/0300060520964373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166396PMC
March 2021

Cephalopod-Inspired Chromotropic Ionic Skin with Rapid Visual Sensing Capabilities to Multiple Stimuli.

ACS Nano 2021 02 2;15(2):3509-3521. Epub 2021 Feb 2.

State Key Laboratory of Fine Chemicals, Dalian University of Technology, West Campus, 2 Linggong Road, Dalian 116024, China.

Biological skin systems can perceive various external stimuli through ion transduction. Especially, the skin of some advanced organisms such as cephalopods can further promptly change body color by manipulating photonic nanostructures. However, the current skin-inspired soft iontronics lack the rapid full-color switching ability to respond to multiple stimuli including tension, pressure, and temperature. Here, an intelligent chromotropic iontronics with these fascinating functions is developed by constructing a biomimetic ultrastructure with anisotropic electrostatic repulsion. This skin-like chromotropic iontronics can synchronously realize electrical response and optical visualization to mechanical strain and tactile sensation by adjusting the ultrastructure in cooperation with ionic mechanotransduction. Notably, it can perform instantaneous geometric changes to thermal stimuli an anisotropic electrostatic repulsion interior. Such a capability allows bionic skin to transduce temperature or infrared light into ionic signals and color changes in real time. The design of anisotropic photonic nanostructures expands the intelligent application for soft iontronics at higher levels, providing a concise, multifunctional, interactive sensing platform that dynamically displays stimuli information on its body.
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http://dx.doi.org/10.1021/acsnano.1c00181DOI Listing
February 2021

Effect Analysis of GNSS/INS Processing Strategy for Sufficient Utilization of Urban Environment Observations.

Sensors (Basel) 2021 Jan 17;21(2). Epub 2021 Jan 17.

College of Geodesy and Geomatics, Shandong University of Science and Technology, Qingdao 266000, China.

The occlusion of buildings in urban environments leads to the intermittent reception of satellite signals, which limits the utilization of observations. This subsequently results in a decline of the positioning and attitude accuracy of Global Navigation Satellite System (GNSS)/Inertial Navigation System (INS) integrated system (GNSS/INS). This study implements a smooth post-processing strategy based on a tightly coupled differential GNSS/INS. Specifically, this strategy used the INS-estimated position to reinitialize integer ambiguity. The GNSS raw observations were input into the Kalman filter to update the measurement. The Rauch-Tung-Striebel smoothing (RTSS) algorithm was used to process the observations of the entire period. This study analyzed the performance of loosely coupled and tightly coupled systems in an urban environment and the improvement of the RTSS algorithm on the navigation solution from the perspective of fully mining the observations. The experimental results of the simulation data and real data show that, compared with the traditional tightly coupled processing strategy which does not use INS-aided integer ambiguity resolution and RTSS algorithm, the strategy in this study sufficiently utilized INS observations and GNSS observations to effectively improve the accuracy of positioning and attitude and ensure the continuity of navigation results in an obstructed environment.
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http://dx.doi.org/10.3390/s21020620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830556PMC
January 2021

Recycling Si waste cut from diamond wire into high performance porous [email protected]@C anodes for Li-ion battery.

J Hazard Mater 2021 Apr 9;407:124778. Epub 2020 Dec 9.

Key Laboratory of Materials Modification by Laser, Ion, and Electron Beams (Ministry of Education), Dalian 116024, China; School of Materials Science and Engineering, Dalian University of Technology, Dalian 116024, China.

The Si particle waste cut from diamond wire in photovoltaic industry is chose as an environmental friendly and low-cost resource for Li-ion battery. In this study, the pollutions of SiO layer, adhered trace metal and organic impurities on the Si particle waste can be removed by the facile processes of corrosion and pyrolysis. The removal ratios of organic and metal impurities were 70.42% and 66.76%, respectively. The different kinetic models for the removal of metal impurities demonstrate that the leaching is more suitable for controlling by second-order reaction of homogeneous models (R =0.992, m=2). The preparation analysis of porous [email protected] with a 3D cluster nanoporous structure using a special bubble corrosion method was firstly proposed and discussed intensively. The first discharge and charge capacities of porous [email protected] @C composites reached 2579.8 and 2184.1 mAh/g, the initial CE reached 84.66%, and the corresponding capacities after 100 cycles reached 1051.4 and 1038.2 mAh/g, which showed the better electrical performance. This study establishes a theoretical basis for recycling Si particle waste cut from diamond wire, and provides technical support for the energy sustainable development.
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http://dx.doi.org/10.1016/j.jhazmat.2020.124778DOI Listing
April 2021
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