Yun-Shen Chan

Yun-Shen Chan

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Yun-Shen Chan

Yun-Shen Chan

Publications by authors named "Yun-Shen Chan"

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15Publications

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A Chemically Defined Feeder-free System for the Establishment and Maintenance of the Human Naive Pluripotent State.

Stem Cell Reports 2019 Oct 12;13(4):612-626. Epub 2019 Sep 12.

Stem Cell and Regenerative Biology, Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2019.08.005DOI Listing
October 2019

In Vivo Mapping of Eukaryotic RNA Interactomes Reveals Principles of Higher-Order Organization and Regulation.

Mol Cell 2016 05 12;62(4):603-17. Epub 2016 May 12.

Stem Cell and Regenerative Biology, Genome Institute of Singapore, A(∗)STAR, Singapore 138672, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.04.028DOI Listing
May 2016

ELABELA Is an Endogenous Growth Factor that Sustains hESC Self-Renewal via the PI3K/AKT Pathway.

Cell Stem Cell 2015 Oct 17;17(4):435-47. Epub 2015 Sep 17.

Institute of Medical Biology, Human Genetics and Embryology Laboratory, A(∗)STAR, Singapore 138648; Institute of Molecular and Cell Biology, A(∗)STAR, Singapore 138673. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.08.010DOI Listing
October 2015

Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways.

Cell 2015 Jul;162(3):564-79

Stem Cell and Regenerative Biology, Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Singapore; Department of Biochemistry, National University of Singapore, 8 Medical Drive, Singapore 117597; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Singapore; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 639798, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.07.001DOI Listing
July 2015

Dynamic transcription of distinct classes of endogenous retroviral elements marks specific populations of early human embryonic cells.

Cell Stem Cell 2015 Feb;16(2):135-41

Gene Regulation Laboratory, Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Singapore; Department of Biochemistry, National University of Singapore, Singapore 117559, Singapore.

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http://dx.doi.org/10.1016/j.stem.2015.01.005DOI Listing
February 2015

Genome-wide kinase-chromatin interactions reveal the regulatory network of ERK signaling in human embryonic stem cells.

Mol Cell 2013 Jun 30;50(6):844-55. Epub 2013 May 30.

Gene Regulation Laboratory, Genome Institute of Singapore, Singapore 138672, Singapore.

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http://dx.doi.org/10.1016/j.molcel.2013.04.030DOI Listing
June 2013

A PRC2-dependent repressive role of PRDM14 in human embryonic stem cells and induced pluripotent stem cell reprogramming.

Stem Cells 2013 Apr;31(4):682-92

Gene Regulation Laboratory, Genome Institute of Singapore, Singapore, Singapore.

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http://doi.wiley.com/10.1002/stem.1307
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http://dx.doi.org/10.1002/stem.1307DOI Listing
April 2013

Transcriptional regulatory networks in embryonic stem cells.

Prog Drug Res 2011 ;67:239-52

Gene Regulation Laboratory, Genome Institute of Singapore, 60 Biopolis Street, #02-01, Genome Building, Singapore, Singapore 138672.

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January 2011

A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity.

Nature 2010 Nov 17;468(7321):316-20. Epub 2010 Oct 17.

Gene Regulation Laboratory, Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672.

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http://dx.doi.org/10.1038/nature09531DOI Listing
November 2010

Transposable elements have rewired the core regulatory network of human embryonic stem cells.

Nat Genet 2010 Jul 6;42(7):631-4. Epub 2010 Jun 6.

Computational and Mathematical Biology, Genome Institute of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1038/ng.600DOI Listing
July 2010

KLF4 and PBX1 directly regulate NANOG expression in human embryonic stem cells.

Stem Cells 2009 Sep;27(9):2114-25

Stem Cell Group, Bioprocessing Technology Institute, A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore.

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http://oar.a-star.edu.sg/jspui/bitstream/123456789/334/1/KLF
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http://doi.wiley.com/10.1002/stem.143
Publisher Site
http://dx.doi.org/10.1002/stem.143DOI Listing
September 2009

Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb.

Nat Cell Biol 2009 Feb 11;11(2):197-203. Epub 2009 Jan 11.

Gene Regulation Laboratory, Genome Institute of Singapore, 60 Biopolis Street, #02-01, Genome Building, Singapore 138672.

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http://dx.doi.org/10.1038/ncb1827DOI Listing
February 2009

A core Klf circuitry regulates self-renewal of embryonic stem cells.

Nat Cell Biol 2008 Mar 10;10(3):353-60. Epub 2008 Feb 10.

Gene Regulation Laboratory, Genome Institute of Singapore, 60 Biopolis Street, #02-01, Genome Building, Singapore 138672.

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http://dx.doi.org/10.1038/ncb1698DOI Listing
March 2008