Yun Yen

Yun Yen

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Development and clinical applications of cancer immunotherapy against PD-1 signaling pathway.

J Biomed Sci 2019 Dec 5;26(1):96. Epub 2019 Dec 5.

PhD Program for Cancer Biology and Drug Discovery, Taipei Medical University, 250 Wu-Hsing Street, Taipei, Taiwan, 110.

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http://dx.doi.org/10.1186/s12929-019-0588-8DOI Listing
December 2019

A homozygous variant in RRM2B is associated with severe metabolic acidosis and early neonatal death.

Eur J Med Genet 2019 Nov 12;62(11):103574. Epub 2018 Nov 12.

Pediatric Genomics Discovery Program, Department of Pediatrics, Section of Critical Care Medicine, Yale University School of Medicine, New Haven, CT, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S17697212183016
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http://dx.doi.org/10.1016/j.ejmg.2018.11.008DOI Listing
November 2019

Does long-term use of antidiabetic drugs changes cancer risk?

Medicine (Baltimore) 2019 Oct;98(40):e17461

Department of Public Health and Community Medicine, Shaikh Khalifa Bin Zayed Al-Nahyan Medical College, Shaikh Zayed Medical Complex, Lahore, Pakistan.

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http://dx.doi.org/10.1097/MD.0000000000017461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783244PMC
October 2019

Host immune response to anti-cancer camptothecin conjugated cyclodextrin-based polymers.

J Biomed Sci 2019 Oct 23;26(1):85. Epub 2019 Oct 23.

TMU Research Center of Cancer Translational Medicine, Taipei Medical University, 11031, Taipei, Taiwan.

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http://dx.doi.org/10.1186/s12929-019-0583-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6806548PMC
October 2019

Targeting Autophagy by MPT0L145, a Highly Potent PIK3C3 Inhibitor, Provides Synergistic Interaction to Targeted or Chemotherapeutic Agents in Cancer Cells.

Cancers (Basel) 2019 Sep 11;11(9). Epub 2019 Sep 11.

The Ph.D. Program for Cancer Molecular Biology and drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 110, Taiwan.

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http://dx.doi.org/10.3390/cancers11091345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770340PMC
September 2019

Rrm2b deletion causes mitochondrial metabolic defects in renal tubules.

Sci Rep 2019 Sep 13;9(1):13238. Epub 2019 Sep 13.

TMU Research Center of Cancer Translational Medicine, Taipei Medical University, 11031, Taipei, Taiwan.

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http://dx.doi.org/10.1038/s41598-019-49663-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744457PMC
September 2019

Cancers in Taiwan: Practical insight from epidemiology, treatments, biomarkers, and cost.

J Formos Med Assoc 2019 Sep 12. Epub 2019 Sep 12.

The PhD Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2019.08.023DOI Listing
September 2019

Granular flow from silos with rotating orifice.

Phys Rev E 2019 Jul;100(1-1):012906

Institute of Physics, Academia Sinica, Taipei, Taiwan, Republic of China.

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http://dx.doi.org/10.1103/PhysRevE.100.012906DOI Listing
July 2019

The Ambivalent Role of lncRNA Xist in Carcinogenesis.

Stem Cell Rev Rep 2019 Apr;15(2):314-323

Graduate Institute of Medical Informatics, Taipei Medical University, Taipei, Taiwan.

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http://dx.doi.org/10.1007/s12015-019-9871-zDOI Listing
April 2019

DHS (trans-4,4'-dihydroxystilbene) suppresses DNA replication and tumor growth by inhibiting RRM2 (ribonucleotide reductase regulatory subunit M2).

Oncogene 2019 03 5;38(13):2364-2379. Epub 2018 Dec 5.

Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.

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http://dx.doi.org/10.1038/s41388-018-0584-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705423PMC
March 2019

Novel Common Genetic Susceptibility Loci for Colorectal Cancer.

Authors:
Stephanie L Schmit Christopher K Edlund Fredrick R Schumacher Jian Gong Tabitha A Harrison Jeroen R Huyghe Chenxu Qu Marilena Melas David J Van Den Berg Hansong Wang Stephanie Tring Sarah J Plummer Demetrius Albanes M Henar Alonso Christopher I Amos Kristen Anton Aaron K Aragaki Volker Arndt Elizabeth L Barry Sonja I Berndt Stéphane Bezieau Stephanie Bien Amanda Bloomer Juergen Boehm Marie-Christine Boutron-Ruault Hermann Brenner Stefanie Brezina Daniel D Buchanan Katja Butterbach Bette J Caan Peter T Campbell Christopher S Carlson Jose E Castelao Andrew T Chan Jenny Chang-Claude Stephen J Chanock Iona Cheng Ya-Wen Cheng Lee Soo Chin James M Church Timothy Church Gerhard A Coetzee Michelle Cotterchio Marcia Cruz Correa Keith R Curtis David Duggan Douglas F Easton Dallas English Edith J M Feskens Rocky Fischer Liesel M FitzGerald Barbara K Fortini Lars G Fritsche Charles S Fuchs Manuela Gago-Dominguez Manish Gala Steven J Gallinger W James Gauderman Graham G Giles Edward L Giovannucci Stephanie M Gogarten Clicerio Gonzalez-Villalpando Elena M Gonzalez-Villalpando William M Grady Joel K Greenson Andrea Gsur Marc Gunter Christopher A Haiman Jochen Hampe Sophia Harlid John F Harju Richard B Hayes Philipp Hofer Michael Hoffmeister John L Hopper Shu-Chen Huang Jose Maria Huerta Thomas J Hudson David J Hunter Gregory E Idos Motoki Iwasaki Rebecca D Jackson Eric J Jacobs Sun Ha Jee Mark A Jenkins Wei-Hua Jia Shuo Jiao Amit D Joshi Laurence N Kolonel Suminori Kono Charles Kooperberg Vittorio Krogh Tilman Kuehn Sébastien Küry Andrea LaCroix Cecelia A Laurie Flavio Lejbkowicz Mathieu Lemire Heinz-Josef Lenz David Levine Christopher I Li Li Li Wolfgang Lieb Yi Lin Noralane M Lindor Yun-Ru Liu Fotios Loupakis Yingchang Lu Frank Luh Jing Ma Christoph Mancao Frank J Manion Sanford D Markowitz Vicente Martin Koichi Matsuda Keitaro Matsuo Kevin J McDonnell Caroline E McNeil Roger Milne Antonio J Molina Bhramar Mukherjee Neil Murphy Polly A Newcomb Kenneth Offit Hanane Omichessan Domenico Palli Jesus P Paredes Cotoré Julyann Pérez-Mayoral Paul D Pharoah John D Potter Conghui Qu Leon Raskin Gad Rennert Hedy S Rennert Bridget M Riggs Clemens Schafmayer Robert E Schoen Thomas A Sellers Daniela Seminara Gianluca Severi Wei Shi David Shibata Xiao-Ou Shu Erin M Siegel Martha L Slattery Melissa Southey Zsofia K Stadler Mariana C Stern Sebastian Stintzing Darin Taverna Stephen N Thibodeau Duncan C Thomas Antonia Trichopoulou Shoichiro Tsugane Cornelia M Ulrich Franzel J B van Duijnhoven Bethany van Guelpan Joseph Vijai Jarmo Virtamo Stephanie J Weinstein Emily White Aung Ko Win Alicja Wolk Michael Woods Anna H Wu Kana Wu Yong-Bing Xiang Yun Yen Brent W Zanke Yi-Xin Zeng Ben Zhang Niha Zubair Sun-Seog Kweon Jane C Figueiredo Wei Zheng Loic Le Marchand Annika Lindblom Victor Moreno Ulrike Peters Graham Casey Li Hsu David V Conti Stephen B Gruber

J Natl Cancer Inst 2019 Feb;111(2):146-157

Department of Preventive Medicine, USC Norris Comprehensive Cancer Center.

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http://dx.doi.org/10.1093/jnci/djy099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555904PMC
February 2019

Liver resection for hepatocellular carcinoma in oldest old patients.

World J Surg Oncol 2019 Jan 3;17(1). Epub 2019 Jan 3.

Department of Surgery, Taichung Veterans General Hospital, Section 4, No. 1650, Taiwan Boulevard, Taichung, Taiwan.

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https://wjso.biomedcentral.com/articles/10.1186/s12957-018-1
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http://dx.doi.org/10.1186/s12957-018-1541-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317186PMC
January 2019

Application of bioconjugation chemistry on biosensor fabrication for detection of TAR-DNA binding protein 43.

Biosens Bioelectron 2018 Oct 1;117:60-67. Epub 2018 Jun 1.

Department of Chemical and Biomolecular Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA; Electronics Design Center, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bios.2018.05.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082407PMC
October 2018

FDA guidance for next generation sequencing-based testing: balancing regulation and innovation in precision medicine.

Authors:
Frank Luh Yun Yen

NPJ Genom Med 2018 3;3:28. Epub 2018 Oct 3.

2PhD Program of Cancer Biology and Drug Discovery, TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan.

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http://dx.doi.org/10.1038/s41525-018-0067-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170456PMC
October 2018

Machine Learning-Based Radiomics for Molecular Subtyping of Gliomas.

Clin Cancer Res 2018 09 22;24(18):4429-4436. Epub 2018 May 22.

Research Center of Translational Imaging, College of Medicine, Taipei Medical University, Taipei, Taiwan.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-3445DOI Listing
September 2018

Benefits and Harms of the Centers for Medicare & Medicaid Services Ruling on Next-Generation Sequencing.

Authors:
Frank Luh Yun Yen

JAMA Oncol 2018 09;4(9):1171-1172

Graduate Institute of Medical Informatics, Taipei Medical University, Taipei, Taiwan.

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http://dx.doi.org/10.1001/jamaoncol.2018.1948DOI Listing
September 2018

Differences in silencing of mismatched targets by sliced versus diced siRNAs.

Nucleic Acids Res 2018 07;46(13):6806-6822

Department of Diabetes Complications & Metabolism, Diabetes and Metabolism Research Institute, Beckman Research Institute of City of Hope, 1500 E. Duarte Road, Duarte, CA 91010-3000, USA.

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http://dx.doi.org/10.1093/nar/gky287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061797PMC
July 2018

Web-Based Platform vs Genetic Counselors in Educating Patients About Carrier Results From Exome Sequencing.

Authors:
Yun Yen Frank Luh

JAMA Intern Med 2018 07;178(7):998-999

Sino-American Cancer Foundation, Temple City, California.

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http://dx.doi.org/10.1001/jamainternmed.2018.2239DOI Listing
July 2018

Dual Inhibition of PIK3C3 and FGFR as a New Therapeutic Approach to Treat Bladder Cancer.

Clin Cancer Res 2018 03 8;24(5):1176-1189. Epub 2017 Dec 8.

The Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-17-2066DOI Listing
March 2018

Phase IB trial of ixabepilone and vorinostat in metastatic breast cancer.

Breast Cancer Res Treat 2018 01 27;167(2):469-478. Epub 2017 Sep 27.

Cancer Research and Drug Discovery Medical Technology College, Taipei Medical University, Taipei, Taiwan.

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http://dx.doi.org/10.1007/s10549-017-4516-xDOI Listing
January 2018

1,4-Naphthoquinones as inhibitors of Itch, a HECT domain-E3 ligase, and tumor growth suppressors in multiple myeloma.

Eur J Med Chem 2017 Nov 6;140:84-91. Epub 2017 Sep 6.

School of Pharmacy, College of Pharmacy, Taipei Medical University, 250 Wuxing Street, Taipei 11031, Taiwan; School of Pharmacy, National Defense Medical Center, Taipei, Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S02235234173069
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http://dx.doi.org/10.1016/j.ejmech.2017.09.011DOI Listing
November 2017

Benzodiazepines use and breast cancer risk: A population-based study and gene expression profiling evidence.

J Biomed Inform 2017 10 26;74:85-91. Epub 2017 Aug 26.

International Center for Health Information Technology (ICHIT), Taipei Medical University, Taipei, Taiwan; Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taiwan; Department of Dermatology, Wan-Fang Hospital, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jbi.2017.08.008DOI Listing
October 2017

Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression.

Nat Commun 2017 06 22;8:15874. Epub 2017 Jun 22.

Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 110, Taiwan.

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http://dx.doi.org/10.1038/ncomms15874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489688PMC
June 2017

Overexpression of Uridine-Cytidine Kinase 2 Correlates with Breast Cancer Progression and Poor Prognosis.

J Breast Cancer 2017 Jun 26;20(2):132-141. Epub 2017 Jun 26.

Integrated Laboratory, Center of Translational Medicine, Taipei Medical University, Taipei, Taiwan.

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http://dx.doi.org/10.4048/jbc.2017.20.2.132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500396PMC
June 2017

Human mitochondrial pyrroline-5-carboxylate reductase 1 promotes invasiveness and impacts survival in breast cancers.

Carcinogenesis 2017 05;38(5):519-531

Ph.D. Program of Cancer Biology and Drug Discovery, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, Taiwan, ROC.

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http://dx.doi.org/10.1093/carcin/bgx022DOI Listing
May 2017

Does aspirin use reduce the risk for cancer?

J Investig Med 2017 02 27;65(2):391-392. Epub 2016 Oct 27.

International Center for Health Information Technology, Taipei, Taiwan.

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http://dx.doi.org/10.1136/jim-2016-000275DOI Listing
February 2017

Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways.

J Hematol Oncol 2017 02 28;10(1):60. Epub 2017 Feb 28.

The PhD Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.

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http://dx.doi.org/10.1186/s13045-017-0421-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329923PMC
February 2017

Precision Medicine and Pancreatic Cancer: A Gemcitabine Pathway Approach.

Pancreas 2016 11;45(10):1485-1493

From the *Yale Center for Pancreatic Disease, Yale School of Medicine, New Haven, CT; †Statistics and Data Management Center, NRG Oncology, Philadelphia, PA; ‡Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI; §Department of Radiation Oncology, University of Maryland, Baltimore, MD; ∥Oncology Program, Toledo Clinic, Toledo, OH; ¶Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL; #Saint Vincent Comprehensive Cancer Center, New York; and **The Oncology Consortia of Criterium Inc, Saratoga Springs, NY; ††California Cancer Institute, Temple City, CA; ‡‡Graduate Institute of Medical Sciences, College of Medicine, and §§Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; ∥∥Department of Pathology, Cross Cancer Center, University of Alberta, Edmonton, Alberta, Canada; ¶¶Department of Pathology, H. Lee Moffitt Cancer Center, Tampa, FL; ##Karmanos Cancer Institute; and ***Department of Oncology and Cancer Biology Graduate Program, Wayne State University, Detroit, MI; †††Department of Radiation Oncology, Montifiore Medical Center, Bronx, NY; and ‡‡‡Department of Radiation Oncology, The Canberra Hospital, Australian National University, Canberra, Australia.

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http://dx.doi.org/10.1097/MPA.0000000000000710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119656PMC
November 2016

The Impact of dUTPase on Ribonucleotide Reductase-Induced Genome Instability in Cancer Cells.

Cell Rep 2016 08 21;16(5):1287-1299. Epub 2016 Jul 21.

Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 112, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.06.094DOI Listing
August 2016

Chemotherapy for advanced biliary tract carcinoma: A meta-analysis of randomized controlled trials.

Medicine (Baltimore) 2016 Aug;95(33):e4584

aCenter for Evidence-based Health Care, Shuang Ho Hospital, Taipei Medical University, New Taipei City bCochrane Taiwan cDepartment of Public Health, School of Medicine, College of Medicine dDivision of Plastic Surgery, Department of Surgery, Wan Fang Hospital eGraduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei fDivision of General Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City gDepartment of Surgery, School of Medicine, College of Medicine, Taipei Medical, University, Taipei, Taiwan.

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http://dx.doi.org/10.1097/MD.0000000000004584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370815PMC
August 2016

Elevated HMGA2 expression is associated with cancer aggressiveness and predicts poor outcome in breast cancer.

Cancer Lett 2016 07 7;376(2):284-92. Epub 2016 Apr 7.

Department of Surgical Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Department of Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2016.04.005DOI Listing
July 2016

Trichlorobenzene-substituted azaaryl compounds as novel FGFR inhibitors exhibiting potent antitumor activity in bladder cancer cells in vitro and in vivo.

Oncotarget 2016 May;7(18):26374-87

The Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041986PMC
http://dx.doi.org/10.18632/oncotarget.8380DOI Listing
May 2016

CRLX101 nanoparticles localize in human tumors and not in adjacent, nonneoplastic tissue after intravenous dosing.

Proc Natl Acad Sci U S A 2016 Apr 21;113(14):3850-4. Epub 2016 Mar 21.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125;

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http://dx.doi.org/10.1073/pnas.1603018113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833237PMC
April 2016

Proton pump inhibitors and risk of periampullary cancers--A nested case-control study.

Int J Cancer 2016 Mar 20;138(6):1401-9. Epub 2015 Nov 20.

Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.

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http://dx.doi.org/10.1002/ijc.29896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738410PMC
March 2016

RRM2B-Mediated Regulation of Mitochondrial Activity and Inflammation under Oxidative Stress.

Mediators Inflamm 2015 18;2015:287345. Epub 2015 May 18.

Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 110, Taiwan.

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http://dx.doi.org/10.1155/2015/287345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451759PMC
February 2016

Research of StemBios Cell Therapy on Dental Implants Containing Nanostructured Surfaces: Biomechanical Behaviors, Microstructural Characteristics, and Clinical Trial.

Implant Dent 2016 Feb;25(1):63-73

*Professor, School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan; Professor, Department of Dentistry, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan; Director, Research Center for Biomedical Devices and Prototyping Production, Taipei Medical University, Taipei, Taiwan; Director, Research Center for Biomedical Implants and Microsurgery Devices, Taipei Medical University, Taipei, Taiwan. †PhD Student, School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan. ‡Graduate Institute of Nanomedicine, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan. §Professor, Department of Pathology, Taipei Medical University, Taipei, Taiwan. ¶Assistant Professor, Department of Dentistry, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan; Researcher, Research Center for Biomedical Devices and Prototyping Production, Taipei Medical University, Taipei, Taiwan. ‖Researcher, Research Center for Biomedical Devices and Prototyping Production, Taipei Medical University, Taipei, Taiwan; Associate Professor, Graduate Institute of Biomedical Materials and Tissue Engineering, Taipei Medical University, Taipei, Taiwan. #Researcher, StemBios Technologies, Monterey Park, CA. **Professor, Department of Molecular Pharmacology, Beckman Research Institute of the City of Hope, Duarte, CA; Professor, Institute of Translational Medicine, Taipei Medical University, Taipei, Taiwan. ††Assistant Professor, Graduate Institute of Biomedical Materials and Tissue Engineering, Taipei Medical University, Taipei, Taiwan; Researcher, Research Center for Biomedical Devices and Prototyping Production, Taipei Medical University, Taipei, Taiwan; Researcher, Research Center for Biomedical Implants and Microsurgery Devices, Taipei Medical University, Taipei, Taiwan. ‡‡Professor, Department of Prosthodontic, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta, Indonesia

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http://dx.doi.org/10.1097/ID.0000000000000337DOI Listing
February 2016

HP1β is a biomarker for breast cancer prognosis and PARP inhibitor therapy.

PLoS One 2015 13;10(3):e0121207. Epub 2015 Mar 13.

Department of Molecular Pharmacology, Beckman Research Institute, City of Hope, Duarte, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121207PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358987PMC
January 2016

Autophagy induction causes a synthetic lethal sensitization to ribonucleotide reductase inhibition in breast cancer cells.

Oncotarget 2016 Jan;7(2):1984-99

Department of Molecular Pharmacology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA.

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http://dx.doi.org/10.18632/oncotarget.6539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811511PMC
January 2016

Lowered circulating aspartate is a metabolic feature of human breast cancer.

Oncotarget 2015 Oct;6(32):33369-81

Center for Translational Medicine, and Shanghai Key Laboratory of Diabetes Mellitus, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

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http://www.oncotarget.com/fulltext/5409
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http://dx.doi.org/10.18632/oncotarget.5409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741772PMC
October 2015

Lovastatin overcomes gefitinib resistance through TNF-α signaling in human cholangiocarcinomas with different LKB1 statuses in vitro and in vivo.

Oncotarget 2015 Sep;6(27):23857-73

PhD Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.

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http://dx.doi.org/10.18632/oncotarget.4408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695157PMC
September 2015

Primary Cutaneous Anaplastic Large Cell Lymphoma With Positive ALK Expression and a Rapidly Progressive Cutaneous Nodule.

Int J Surg Pathol 2015 Jun 29;23(4):333-5. Epub 2015 Jan 29.

City of Hope Comprehensive Cancer Center, Duarte, CA, USA

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http://dx.doi.org/10.1177/1066896915568993DOI Listing
June 2015

Non-enzymatic action of RRM1 protein upregulates PTEN leading to inhibition of colorectal cancer metastasis.

Tumour Biol 2015 Jun 1;36(6):4833-42. Epub 2015 Feb 1.

Department of Pathology and Pathophysiology, Zhejiang Key Laboratory for Disease Proteomics, Research Center for Air Pollution and Health, Zhejiang University School of Medicine, Hangzhou, 310058, China.

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http://dx.doi.org/10.1007/s13277-015-3137-4DOI Listing
June 2015

The Novel Ribonucleotide Reductase Inhibitor COH29 Inhibits DNA Repair In Vitro.

Mol Pharmacol 2015 Jun 26;87(6):996-1005. Epub 2015 Mar 26.

Departments of Molecular Pharmacology (B.Z., K.Z., F.U., S.H., X.L., D.L.S., Y.Y.), Molecular Medicine (Y.-C.Y., H.L., Z.L., C.D.W., L.S.), Molecular and Cellular Biology (L.H.M.), and Division of Comparative Medicine (J.W., Y.W.), City of Hope National Medical Center, Duarte, California; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology Stanford University School of Medicine, Stanford, California; (Y.M.C., M.C.-T.H.); Ph.D. Program for the Clinical Drug Discovery from Botanical Herbs, College of Pharmacy (M.-C.C.), and Graduate Institute of Pharmacognosy, College of Pharmacy, (M.-C.C), Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology (C.-H.C., Y.Y.), and Department of Biochemistry, School of Medicine, College of Medicine (C.-M.C.), Taipei Medical University, Taipei, Taiwan

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http://dx.doi.org/10.1124/mol.114.094987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429719PMC
June 2015

Clinical research of mortality in emergency air medical transport.

Biomed Res Int 2014 4;2014:767402. Epub 2014 Aug 4.

Institute of Injury Prevention and Control, Taipei Medical University, Taipei 110, Taiwan ; College of Public Health and Nutrition, Taipei Medical University, Taipei 110, Taiwan ; Department of Emergency, College of Medicine and Shuang Ho Hospital, Taipei Medical University, Taipei 235, Taiwan.

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http://dx.doi.org/10.1155/2014/767402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137728PMC
May 2015

Fibronectin promotes cell proliferation and invasion through mTOR signaling pathway activation in gallbladder cancer.

Cancer Lett 2015 May 2;360(2):141-50. Epub 2015 Feb 2.

Department of General Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Institute of Biliary Tract Disease, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2015.01.041DOI Listing
May 2015

Detection and phenotyping of circulating tumor cells in high-risk localized prostate cancer.

Clin Genitourin Cancer 2015 Apr 22;13(2):130-6. Epub 2014 Sep 22.

Department of Molecular Pharmacology, City of Hope Comprehensive Cancer Center, Duarte, CA. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2014.08.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479263PMC
April 2015

Response to Trevisson et al.

Genet Med 2015 Apr;17(4):313-4

1] Department of Molecular Pharmacology, Beckman Research Institute of the City of Hope National Medical Center, Duarte, California, USA [2] PhD Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.

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http://dx.doi.org/10.1038/gim.2014.212DOI Listing
April 2015

Is long-term use of benzodiazepine a risk for cancer?

Medicine (Baltimore) 2015 Feb;94(6):e483

From the Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan (UI, P-AN, SS-A, H-CY, CWH, M-HH, YY, YC(J)L); Institute of Biomedical Informatics, National Yang Ming University, Taipei, Taiwan (H-CY); School of Health Care Administration, Taipei Medical University, Taipei, Taiwan (W-SJ); Department of Health, Taipei Hospital, Taiwan (M-HH); City of Hope, Duarte, CA, USA (YY); Department of Dermatology, Wan Fang Hospital, Taipei, Taiwan (Y-C(J)L).

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http://dx.doi.org/10.1097/MD.0000000000000483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602739PMC
February 2015

Molecular Properties, Functional Mechanisms, and Applications of Sliced siRNA.

Mol Ther Nucleic Acids 2015 Jan 20;4:e221. Epub 2015 Jan 20.

Department of Molecular Pharmacology, Beckman Research Institute of the City of Hope, Duarte, California, USA.

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http://dx.doi.org/10.1038/mtna.2014.73DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345305PMC
January 2015

Anti-proliferative and gene expression actions of resveratrol in breast cancer cells in vitro.

Oncotarget 2014 Dec;5(24):12891-907

Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Albany, New York, USA. Albany Medical College, Albany, New York, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350334PMC
http://dx.doi.org/10.18632/oncotarget.2632DOI Listing
December 2014

Curative use of forequarter amputation for recurrent breast cancer over an axillary area: a case report and literature review.

World J Surg Oncol 2014 Nov 18;12:346. Epub 2014 Nov 18.

Department of Molecular Pharmacology, City of Hope National Medical Center and Beckman Research Center, 1500 East Duarte Road, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1186/1477-7819-12-346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246546PMC
November 2014

A germline missense mutation in COQ6 is associated with susceptibility to familial schwannomatosis.

Genet Med 2014 Oct 24;16(10):787-92. Epub 2014 Apr 24.

1] Department of Molecular Pharmacology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, USA [2] PhD Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.

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http://dx.doi.org/10.1038/gim.2014.39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189385PMC
October 2014

Pharmacodynamic and pharmacogenomic study of the nanoparticle conjugate of camptothecin CRLX101 for the treatment of cancer.

Nanomedicine 2014 Oct 22;10(7):1477-86. Epub 2014 Apr 22.

Department of Molecular Pharmacology, Beckman Research Institute of the City of Hope, Duarte, CA, USA; Institute of Translational Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.nano.2014.04.003DOI Listing
October 2014

Identification of a distinct small cell population from human bone marrow reveals its multipotency in vivo and in vitro.

PLoS One 2014 17;9(1):e85112. Epub 2014 Jan 17.

Board Member of the Scientific Advisory Board, StemBios Technologies, Inc., Monterey Park, California, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894949PMC
September 2014

Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy.

Proc Natl Acad Sci U S A 2014 Sep 13;111(39):14147-52. Epub 2014 Aug 13.

Department of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, Sacramento, CA 95817; Integrated Laboratory, Center of Translational Medicine and National Health Research Institutes, Taipei, Taiwan 115, Republic of China

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http://dx.doi.org/10.1073/pnas.1404171111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191793PMC
September 2014

Prognostic and therapeutic significance of ribonucleotide reductase small subunit M2 in estrogen-negative breast cancers.

BMC Cancer 2014 Sep 11;14:664. Epub 2014 Sep 11.

Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, 310009 Hangzhou, Zhejiang, China.

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http://dx.doi.org/10.1186/1471-2407-14-664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171582PMC
September 2014

Correlating animal and human phase Ia/Ib clinical data with CALAA-01, a targeted, polymer-based nanoparticle containing siRNA.

Proc Natl Acad Sci U S A 2014 Aug 21;111(31):11449-54. Epub 2014 Jul 21.

College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan;Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, CA 91010;

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http://www.pnas.org/cgi/doi/10.1073/pnas.1411393111
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http://dx.doi.org/10.1073/pnas.1411393111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128111PMC
August 2014

Reciprocal regulation of autophagy and dNTP pools in human cancer cells.

Autophagy 2014 Jul 16;10(7):1272-84. Epub 2014 May 16.

Department of Molecular Pharmacology; Beckman Research Institute; City of Hope National Medical Center; Duarte, CA USA; Taipei Medical University; Taipei, Taiwan.

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http://dx.doi.org/10.4161/auto.28954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203552PMC
July 2014

Jejunal Cancer with WRN Mutation Identified from Next-Generation Sequencing: A Case Study and Minireview.

Case Rep Surg 2014 15;2014:126924. Epub 2014 Jun 15.

Department of Molecular Pharmacology, City of Hope National Medical Center and Beckman Research Center, 1500 E Duarte Road, Duarte, CA 91010, USA ; Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, Taiwan.

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http://dx.doi.org/10.1155/2014/126924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082912PMC
July 2014

The role of peroxiredoxin II in chemoresistance of breast cancer cells.

Breast Cancer (Dove Med Press) 2014 23;6:73-80. Epub 2014 May 23.

Department of Clinical and Molecular Pharmacology, Beckman Research Institute of City of Hope National Medical Center, Duarte, CA, USA.

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http://www.dovepress.com/the-role-of-peroxiredoxin-ii-in-che
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http://dx.doi.org/10.2147/BCTT.S61281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041024PMC
June 2014

Mutants TP53 p.R273H and p.R273C but not p.R273G enhance cancer cell malignancy.

Hum Mutat 2014 May 7;35(5):575-84. Epub 2014 Apr 7.

Department of Laboratory Medicine, M.O.E. Key Laboratory of Laboratory Medicine Diagnostics, Chongqing Medical University, Chongqing, 400016, P. R. China.

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http://dx.doi.org/10.1002/humu.22528DOI Listing
May 2014

A distinct metabolic signature of human colorectal cancer with prognostic potential.

Clin Cancer Res 2014 Apr 13;20(8):2136-46. Epub 2014 Feb 13.

Authors' Affiliations: Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Department of Colorectal Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences; Med-X Institutes, Shanghai Jiao Tong University, Shanghai; State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; Cancer Institute, 2nd Hospital Affiliated to School of Medicine, Zhejiang University, Hangzhou, PR China; Center for translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, North Carolina; Department of Medical Oncology and Therapeutic Research, City of Hope Comprehensive Cancer Center, Duarte, California; and Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902798PMC
April 2014

Wnt modulates MCL1 to control cell survival in triple negative breast cancer.

BMC Cancer 2014 Feb 24;14:124. Epub 2014 Feb 24.

Department of Molecular Pharmacology, Beckman Research Institute, City of Hope National Medical Center, Beckman Building, Room 4117, 1500 East Duarte Road, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1186/1471-2407-14-124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936852PMC
February 2014