Publications by authors named "Yun Ni"

27 Publications

  • Page 1 of 1

The spin-dependent transport properties of defected zigzag graphene nanoribbons with graphene nanobubbles.

Phys Chem Chem Phys 2021 Feb;23(4):2753-2761

College of Science, Henan University of Engineering, Zhengzhou, 451191, China.

Zigzag-edged graphene nanoribbons (ZGNRs) have important applications in spintronics and spin caloritronics. While in the preparation of a ZGNR, defects like the graphene nanobubbles often appear, which may affect the physical properties of the ZGNR. In this paper, we studied the transport properties of a defected ZGNR with a graphene nanobubble by performing first-principles quantum transport calculations. The results show that when the nanobubble is intact and locates at the centre, the spin polarization and magnetoresistance tend to drop off in the low bias voltage cases, compared to the ideal ZGNR. While when the nanobubble is split and locates at the edge, all the transport properties are significantly affected and altered, such as the spin polarization, the giant magnetoresistance effect and the spin Seebeck effect. Meanwhile, some new results are obtained from the device, including the negative differential resistance effect and the pure thermal-induced spin-current.
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http://dx.doi.org/10.1039/d0cp05640eDOI Listing
February 2021

Rational Design of a Two-Photon Fluorogenic Probe for Visualizing Monoamine Oxidase A Activity in Human Glioma Tissues.

Angew Chem Int Ed Engl 2020 05 13;59(19):7536-7541. Epub 2020 Mar 13.

Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing, 211816, P. R. China.

Monoamine oxidases have two functionally distinct but structurally similar isoforms (MAO-A and MAO-B). The ability to differentiate them by using fluorescence detection/imaging technology is of significant biological relevance, but highly challenging with available chemical tools. Herein, we report the first MAO-A-specific two-photon fluorogenic probe (F1), capable of selective imaging of endogenous MAO-A enzymatic activities from a variety of biological samples, including MAO-A-expressing neuronal SY-SY5Y cells, the brain of tumor-bearing mice and human Glioma tissues by using two-photon fluorescence microscopy (TPFM) with minimal cytotoxicity.
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http://dx.doi.org/10.1002/anie.202000059DOI Listing
May 2020

Gap-Induced Giant Third-Order Optical Nonlinearity and Long Electron Relaxation Time in Random-Distributed Gold Nanorod Arrays.

ACS Appl Mater Interfaces 2019 Sep 23;11(35):32469-32474. Epub 2019 Aug 23.

Wuhan National High Magnetic Field Center and School of Physics , Huazhong University of Science and Technology , Wuhan 430074 , P. R. China.

The third-order optical nonlinearities and the hot electron relaxation time (τ) of random-distributed gold nanorods arrays on glass (R-GNRA) have been investigated by using Z-scan and optical Kerr effect (OKE) techniques. Large third-order optical susceptibility (χ) with the value of 2.5 × 10 esu has been obtained around the plamsonic resonance peak under the excitation power intensity of 0.1 GW/cm. Further decrease of the excitation power intensity down to 0.3 MW/cm will lead to the significant increase of χ up to 6.4 × 10 esu. The OKE results show that the relaxation time of R-GNRA around the plasmonic peak is 13.9 ± 0.4 ps, which is more than 4 times longer than those of the individual gold nanostructures distributed in water solutions. The Finite-difference time domain simulations demonstrate that this large enhancement of χ and slow down of τ are caused by the gap-induced large local field enhancement of GNRs dimers in R-GNRA. These significant results offer great opportunities for plasmonic nanostructures in applications of photonic and photocatalytic devices.
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http://dx.doi.org/10.1021/acsami.9b08935DOI Listing
September 2019

Water-soluble chiral CdSe/CdS dot/rod nanocrystals for two-photon fluorescence lifetime imaging and photodynamic therapy.

Nanoscale 2019 Aug;11(32):15245-15252

College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.

Compared with traditional organic contrast agents, semiconductor nanocrystals (NCs) have unique optical properties that are vital for biological applications with ultrahigh sensitivities, such as long fluorescence lifetime and large multiphoton absorption (MPA). However, the MPA properties and biological applications of chiral-ligand-stabilized semiconductor NCs have scarcely been reported, which seriously hinders their relevant applications. In this work, we report the aqueous phase transfer of CdSe/CdS dot/rod NCs with the use of cysteine molecules, after which the NCs preserve their high fluorescence quantum yield, long lifetime, and efficient circular dichroism. More importantly, the investigated dot/rod NCs show extremely large two- and three-photon absorption action cross-sections in the first and second biological windows, with maximum values of ∼21 000 GM at 800 nm and ∼4.6 × 10-78 cm6 s2 per photon2 at 1300 nm, which are among the largest values reported for water-soluble fluorescent nanoparticles. Interestingly, the dot/rod NCs exhibit a high singlet oxygen generation efficiency of 35%. In addition, for the first time, two-photon fluorescence lifetime imaging and photodynamic therapy of the dot/rod NCs were successfully demonstrated. The performed investigation of the optical properties of these water-soluble CdSe/CdS dot/rod NCs indicates that they are promising candidates for nonlinear biological imaging applications.
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http://dx.doi.org/10.1039/c9nr04508bDOI Listing
August 2019

Mitochondria-Targeted Two-Photon Fluorescent Photosensitizers for Cancer Cell Apoptosis via Spatial Selectability.

Adv Healthc Mater 2019 07 13;8(14):e1900212. Epub 2019 May 13.

Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing, 210009, P. R. China.

Organelle-targeted photosensitizers have been reported to be effective cell apoptosis agents. Mitochondria is recognized as an ideal target for cancer treatment due to its central role in oxidative metabolism and apoptosis. Meanwhile, two-photon (TP) fluorescence microscopy has become a powerful tool for fluorescence imaging in biological events based on its minimizing photodamage/photobleaching and intrinsic 3D resolution in deep tissues and in vivo. In this study, a series of novel mitochondrial-targeted TP fluorescent photosensitizers (TP-tracers) are designed, synthesized, and systematically investigated. These TP-tracers exhibit extraordinary anti-interference capability among different cations, anions, and amino acids as well as the insensitivity to the changes of pH and complex biological environments. TP-tracers are further used in fluorescence living cells, Drosophila brains, and zebrafish imaging with low cytotoxicity, excellent mitochondria-targeting, and TP properties. The results demonstrate efficient mitochondria-targeting cell selective apoptosis based on TP-activated cancer cells with highly single cell selectivity, and the pharmacokinetic study reveals that MitoY2 does not have accumulation in rats. It is believed that these molecules hold great potential in TP-related smart phototherapy.
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http://dx.doi.org/10.1002/adhm.201900212DOI Listing
July 2019

Rational design of NIR fluorescence probes for sensitive detection of viscosity in living cells.

Spectrochim Acta A Mol Biomol Spectrosc 2019 May 18;214:339-347. Epub 2019 Feb 18.

Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic In-novation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing 211816, PR China; Shaanxi Institute of Flexible Electronics (SIFE), Northwestern Polytechnical University (NPU), 127 West Youyi Road, Xi'an 710072, PR China. Electronic address:

Developing near-infrared (NIR) fluorescence probes for detection of intracellular viscosity is still sufficiently challenging. In this work, three kinds of D-A-D type naphthyl and 2,1,3‑benzoxadiazol hybrid NIR dyes functionalized with amino (NY1), N‑methylamino (NY2) and N,N‑dimethylamino (NY3) groups for intracellular micro-viscosity detection were designed and synthesized. All the probes exhibited very weak NIR emission in low viscosity environment and obvious fluorescence enhancement with the increased viscosity. Different substituent groups had a high impact on the photophysical properties and response sensitive of the probes to viscosity. The structure-property relationships were systematic investigated. The results showed that stronger electron-donating ability and larger steric effect of N,N‑dimethylamino led to a narrower energy gap and more sensitive to viscosity environment. Therefore, NY3 exhibited higher signal noise ratio for viscosity detection and was successfully applied for imaging the changes of intracellular micro-viscosity. This work provides an efficient way to design powerful NIR fluorescence probes for viscosity detection.
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http://dx.doi.org/10.1016/j.saa.2019.02.068DOI Listing
May 2019

Accurate Light Field Depth Estimation With Superpixel Regularization Over Partially Occluded Regions.

IEEE Trans Image Process 2018 Oct;27(10):4889-4900

Depth estimation is a fundamental problem for light field photography applications. Numerous methods have been proposed in recent years, which either focus on crafting cost terms for more robust matching, or on analyzing the geometry of scene structures embedded in the epipolar-plane images. Significant improvements have been made in terms of overall depth estimation error; however, current state-of-the-art methods still show limitations in handling intricate occluding structures and complex scenes with multiple occlusions. To address these challenging issues, we propose a very effective depth estimation framework which focuses on regularizing the initial label confidence map and edge strength weights. Specifically, we first detect partially occluded boundary regions (POBR) via superpixel-based regularization. Series of shrinkage/reinforcement operations are then applied on the label confidence map and edge strength weights over the POBR. We show that after weight manipulations, even a low-complexity weighted least squares model can produce much better depth estimation than the state-of-the-art methods in terms of average disparity error rate, occlusion boundary precision-recall rate, and the preservation of intricate visual features.
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http://dx.doi.org/10.1109/TIP.2018.2839524DOI Listing
October 2018

Cell- and Tissue-Based Proteome Profiling and Bioimaging with Probes Derived from a Potent AXL Kinase Inhibitor.

Chem Asian J 2018 Sep 7;13(18):2601-2605. Epub 2018 Aug 7.

School of Pharmacy, Jinan University, Guangzhou City Key Laboratory of Precision Chemical Drug Development, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development, Ministry of Education (MOE) of People's Republic of China, 601 Huangpu Avenue West, Guangzhou, 510632, China.

AXL has been defined as a novel target for cancer therapeutics. However, only a few potent and selective inhibitors targeting AXL are available to date. Recently, our group has developed a lead compound, 9im, capable of displaying potent and specific inhibition of AXL. To further identify the cellular on/off targets, in this study, competitive affinity-based proteome profiling was carried out, leading to the discovery of several unknown cellular targets such as BCAP31, LPCAT3, POR, TM9SF3, SCCPDH and CANX. In addition, trans-cyclooctene (TCO) and acedan-containing probes were developed to image the binding between 9im and its target proteins inside live cells and tumor tissues. These probes would be useful tools in the detection of AXL in various biosystems.
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http://dx.doi.org/10.1002/asia.201800605DOI Listing
September 2018

Ligand-displacement-based two-photon fluorogenic probe for visualizing mercapto biomolecules in live cells, Drosophila brains and zebrafish.

Analyst 2018 Jul;143(14):3433-3441

Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing, 211816, P. R. China.

Investigating the change in expression level of mercapto biomolecules (GSH/Cys/Hcy) necessitates a rapid detection method for a series of physiological and pathological processes. Herein, we present a ligand-displacement-based two-photon fluorogenic probe based on an Fe(iii) complex, TPFeS, which is a GSH/Cys/Hcy rapid detection fluorogenic probe for in vitro analysis and live cell/tissue/in vivo imaging. The "in situ" probe is non-fluorescent and was prepared from a 1 : 2 ratio of Fe(iii) and TPS, a novel two-photon (TP) fluorophore with excellent one-photon (OP) and TP properties under physiological conditions, as a fluorescent ligand. This probe shows a rapid and remarkable fluorescence restoration (OFF-ON) property due to the ligand-displacement reaction of mercapto biomolecules in a recyclable manner in vitro. A significant two-photon action cross-section, good selectivity for biothiols, low cytotoxicity, and insensitivity to pH over the biologically relevant pH range allowed the direct visualization of mercapto biomolecules at different levels between normal/drug-treated live cells, as well as in Drosophila brain tissues/zebrafish based on the use of two-photon fluorescence microscopy.
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http://dx.doi.org/10.1039/c8an00453fDOI Listing
July 2018

Maximizing Aggregation of Organic Fluorophores to Prolong Fluorescence Lifetime for Two-Photon Fluorescence Lifetime Imaging.

Adv Healthc Mater 2018 08 28;7(15):e1800299. Epub 2018 May 28.

Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, Nanjing, 210023, China.

Two-photon fluorescence lifetime imaging (TP-FLIM) not only permits imaging deep inside the tissues with precise spatial manipulation but also circumvents tissue autofluorescence, holding tremendous promise in molecular imaging. However, the serious lack of suitable contrast agents with long fluorescence lifetime and efficient two-photon absorption (TPA) greatly limits the advance of TP-FLIM. This study reports a simple approach to fabricate water-soluble organic semiconducting nanoparticles [thioxanthone (TXO) NPs] with ultralong fluorescence lifetime and efficient TPA for in vivo TP-FLIM. The approach utilizes the aggregation of a specifically selected thermally activated delayed fluorescence (TADF) fluorophore to prolong its fluorescence lifetime. Encapsulating the TADF fluorophore within an amphiphilic copolymer not only maximizes its aggregation but also obtains TXO NPs with efficient TPA. Importantly, as-prepared TXO NPs exhibit a considerably long fluorescence lifetime at a magnitude of 4.2 µs, which is almost 1000 times larger than that of existing organic contrast agents. Moreover, such long fluorescence lifetime is almost oxygen-inert, readily realizing both in vitro and in vivo TP-FLIM. This work may set valuable guidance for designing organic semiconducting materials with ultralong fluorescence lifetimes to fulfill the potential of FLIM.
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http://dx.doi.org/10.1002/adhm.201800299DOI Listing
August 2018

Cell- and Tissue-Based Proteome Profiling and Dual Imaging of Apoptosis Markers with Probes Derived from Venetoclax and Idasanutlin.

Angew Chem Int Ed Engl 2018 07 25;57(30):9284-9289. Epub 2018 Jun 25.

School of Pharmacy, Jinan University, Guangzhou City Key, Laboratory of Precision Chemical Drug Development, International Cooperative Laboratory of Traditional Chinese, Medicine Modernization and Innovative Drug Development, Ministry of Education (MOE) of People's Republic of China, 601 Huangpu Avenue West, Guangzhou, 510632, China.

Venetoclax (ABT-199) and idasanutlin (RG7388) are efficient anticancer drugs targeting two essential apoptosis markers, Bcl-2 and MDM2, respectively. Recent studies have shown that the combination of these two drugs leads to remarkable enhancement of anticancer efficacy, both in vitro and in vivo. In an attempt to disclose the relationships of their protein targets, competitive affinity-based proteome profiling coupled with bioimaging was employed to characterize their protein targets in the same cancer cell line and tumor tissue. A series of protein hits, including ITPR1, GSR, RER1, PDIA3, Apoa1, and Tnfrsf17 were simultaneously identified by pull-down/LC-MS/MS with the two sets of affinity-based probes. Dual imaging was successfully carried out, with the simultaneous detection of Bcl-2 and MDM2 expression in various cancer cells. This could facilitate the novel diagnostic and therapeutic strategies of dual targeting of Bcl-2/MDM2.
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http://dx.doi.org/10.1002/anie.201802003DOI Listing
July 2018

A ferrocene∩europium assembly showing phototriggered anticancer activity and fluorescent modality imaging.

Dalton Trans 2018 Jan;47(5):1479-1487

Institute of Advanced Materials, Nanjing Tech University, Nanjing 210009, P.R. China.

Two macrocyclic ferrocenophanes containing a coumarin fluorophore, SeN[7]ferrocenophane (fc1), and SeN[7,7]ferrocenophane (fc2), construct an assembly of fc1-HClO[Eu(CHCOO)(HO)(ClO)] (fc1∩Eu) and fc2-2H{ClO[Eu(CHCOO)(HO)(ClO)]} (fc2∩Eu) via a N-HO hydrogen bond and a coordinate bond between Eu and ClO. In fc1∩Eu, UV light irradiation triggers non-covalent bond cleavage to release a ferrocenium and Eu complex, accompanying chromism and luminescence signals. Investigations through the steady-state UV-vis absorption, fluorescence, time-resolved fluorescence, femtosecond transient absorption spectra and electrochemical characterization elucidate a stepwise mechanism: firstly, an effective electron transfer occurs from a ferrocene unit to the singlet state of a coumarin unit; the following proton-coupled electron transfer (PCET) reduces Eu and results in a non-covalent interaction cleavage. Further in vitro exploration of fc1∩Eu in HepG2 cells demonstrated phototriggered integrated cell cytotoxicity and fluorescent modality imaging.
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http://dx.doi.org/10.1039/c7dt04492eDOI Listing
January 2018

Visible-Light-Excited Ultralong Organic Phosphorescence by Manipulating Intermolecular Interactions.

Adv Mater 2017 Sep 17;29(35). Epub 2017 Jul 17.

Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing, 211816, P. R. China.

Visible light is much more available and less harmful than ultraviolet light, but ultralong organic phosphorescence (UOP) with visible-light excitation remains a formidable challenge. Here, a concise chemical approach is provided to obtain bright UOP by tuning the molecular packing in the solid state under irradiation of available visible light, e.g., a cell phone flashlight under ambient conditions (room temperature and in air). The excitation spectra exhibit an obvious redshift via the incorporation of halogen atoms to tune intermolecular interactions. UOP is achieved through H-aggregation to stabilize the excited triplet state, with a high phosphorescence efficiency of 8.3% and a considerably long lifetime of 0.84 s. Within a brightness of 0.32 mcd m that can be recognized by the naked eye, UOP can last for 104 s in total. Given these features, ultralong organic phosphorescent materials are used to successfully realize dual data encryption and decryption. Moreover, well-dispersed UOP nanoparticles are prepared by polymer-matrix encapsulation in an aqueous solution, and their applications in bioimaging are tentatively being studied. This result will pave the way toward expanding metal-free organic phosphorescent materials and their applications.
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http://dx.doi.org/10.1002/adma.201701244DOI Listing
September 2017

A fluorescent probe based upon anthrancene-dopamine thioether for imaging Hg ions in living cells.

Talanta 2017 May 6;167:681-687. Epub 2017 Mar 6.

School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, PR China.

A novel anthrancene-dopamine thioether L compound was designed as fluorescent probe for detecting Hg in living cells sample. L exhibits a good sensitive and selective recognition towards Hg ions in the presence of other important relevant metal ions and amino acids in HEPES solution. The addition of Hg causes a marked enhancement in the fluorescence emission intensity with the detection limit as low as 1.1×10M, combining with obvious colormetric change from colorless to pale brown. Mechanistic studies show that catechol group and sulfur atom in L all participate in the coordination with Hg, though catechol group contributes mainly to chelation-enhanced fluorescence enhancement and sulfur atom to selectivity. Furthermore, L demonstrates good cell permeability and compatibility for sensitive fluorescent detection of Hg in HepG2 cells. This present probe will have broad applications in biological imaging.
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http://dx.doi.org/10.1016/j.talanta.2017.03.012DOI Listing
May 2017

The spin-dependent transport properties of zigzag α-graphyne nanoribbons and new device design.

Sci Rep 2016 05 16;6:25914. Epub 2016 May 16.

School of Physics and Wuhan National High Magnetic Field Center, Huazhong University of Science and Technology, Wuhan, China, 430074.

By performing first-principle quantum transport calculations, we studied the electronic and transport properties of zigzag α-graphyne nanoribbons in different magnetic configurations. We designed the device based on zigzag α-graphyne nanoribbon and studied the spin-dependent transport properties, whose current-voltage curves show obvious spin-polarization and conductance plateaus. The interesting transport behaviours can be explained by the transport spectra under different magnetic configurations, which basically depends on the symmetry matching of the electrodes' bandstructures. Simultaneously, spin Seebeck effect is also found in the device. Thus, according to the transport behaviours, zigzag α-graphyne nanoribbons can be used as a dual spin filter diode, a molecule signal converter and a spin caloritronics device, which indicates that α-graphyne is a promising candidate for the future application in spintronics.
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http://dx.doi.org/10.1038/srep25914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867500PMC
May 2016

Giant magnetoresistance in zigzag MoS2 nanoribbons.

Phys Chem Chem Phys 2015 Apr;17(15):10074-9

School of Physics and Wuhan National High Magnetic Field Center, Huazhong University of Science and Technology, Wuhan 430074, China.

Using first principles calculations based on density functional theory, we investigated the transport properties of zigzag MoS2 nanoribbons with parallel and antiparallel spin configurations. The results show that the parallel configuration has conventional metallic properties while the antiparallel configuration presents semiconductor properties. Consequently, the conduction calculations predict that the zigzag MoS2 nanoribbons exhibit the giant magnetoresistance effect with a value over four orders of magnitude at room temperature by altering the configuration from the parallel to the antiparallel spin junction. By analyzing the spin-resolved band structures of zigzag MoS2 nanoribbons, we clarify that the orbital mismatching near the Fermi level between spin up and spin down is a key factor to generate this large magnetoresistance. Our results indicate that the giant magnetoresistance effect in the zigzag MoS2 nanoribbons remains robust to the change in the ribbon widths and lengths.
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http://dx.doi.org/10.1039/c4cp04892jDOI Listing
April 2015

GATA-binding protein 3, gross cystic disease fluid protein-15 and mammaglobin have distinct prognostic implications in different invasive breast carcinoma subgroups.

Histopathology 2015 Jul 21;67(1):96-105. Epub 2015 Jan 21.

Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong.

Aims: To evaluate the prognostic significance of GATA-binding protein 3 (GATA-3), gross cystic disease fluid protein-15 (GCDFP-15) and mammaglobin (MGB) in invasive breast carcinomas (IBCs).

Methods And Results: GATA-3, GCDFP-15 and MGB were expressed in 37.9% (370/976), 26.0% (254/978) and 35.3% (348/986) of this cohort of 1017 IBCs, respectively. GCDFP-15 was an independent favourable prognostic factor in all cases [disease-free survival (DFS), hazard ratio (HR) 0.587, P = 0.049; overall survival (OS), HR 0.512, P = 0.049], as well as in oestrogen receptor (ER)-negative (DFS, HR 0.353, P = 0.012; OS, HR 0.310, P = 0.017) and HER2-positive (DFS, HR 0.279, P = 0.036; OS, HR 0.235, P = 0.050) cases; it also refined the prognostication of molecular apocrine cancers. GATA-3 and MGB did not show any prognostic significance.

Conclusions: The commonly used breast carcinoma biomarkers vary in their prognostic implications. GCDFP-15 independently indicated a favourable prognosis, especially in ER-negative, HER2-positive and molecular apocrine cancers. GATA-3 and MGB were not associated with outcome.
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http://dx.doi.org/10.1111/his.12625DOI Listing
July 2015

Thermal spin filtering, thermal spin switching and negative-differential-resistance in thermal spin currents in zigzag SiC nanoribbons.

Phys Chem Chem Phys 2014 Sep;16(33):17493-8

College of Physics and Wuhan national high magnetic field center, Huazhong University of Science and Technology, Wuhan 430074, China.

Spin caloritronics with a combination of spintronics and thermoelectrics has potential applications in future information science and opens a new direction in the development of multi-functional materials. Based on density functional theory and the nonequilibrium Green's function method, we calculate thermal spin-dependent transport through a zigzag silicon carbide nanoribbon (ZSiCNR), which is a heterojunction consisting of a left electrode (ZSiC-2H1H) and right electrode terminated (ZSiC-1H1H) by hydrogen. Our results show that when the temperature in the left contact increases over a critical value, the thermal spin-down current increases remarkably from zero, while the thermal spin-up current remains zero in the total-temperature region, indicating that a perfect thermal spin filter together with a perfect spin switcher is obtained. Furthermore, the thermal spin current shows a negative differential resistance effect and quantum oscillation behaviors. These results suggest that the zigzag SiC nanoribbon proposed by us can be designed as a highly-efficient spin caloritronics device with multiple functionalities.
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http://dx.doi.org/10.1039/c4cp01886aDOI Listing
September 2014

Nearly perfect spin filter, spin valve and negative differential resistance effects in a Fe4-based single-molecule junction.

Sci Rep 2014 May 2;4:4838. Epub 2014 May 2.

School of Physics and Wuhan National High Magnetic Field Center, Huazhong University of Science and Technology, Wuhan 430074, China.

The spin-polarized transport in a single-molecule magnet Fe4 sandwiched between two gold electrodes is studied, using nonequilibrium Green's functions in combination with the density-functional theory. We predict that the device possesses spin filter effect (SFE), spin valve effect (SVE), and negative differential resistance (NDR) behavior. Moreover, we also find that the appropriate chemical ligand, coupling the single molecule to leads, is a key factor for manipulating spin-dependent transport. The device containing the methyl ligand behaves as a nearly perfect spin filter with efficiency approaching 100%, and the transport is dominated by transmission through the Fe4 metal center. However, in the case of phenyl ligand, the spin filter effect seems to be reduced, but the spin valve effect is significantly enhanced with a large magnetoresistance ratio, reaching 1800%. This may be attributed to the blocking effect of the phenyl ligands in mediating transport. Our findings suggest that such a multifunctional molecular device, possessing SVE, NDR and high SFE simultaneously, would be an excellent candidate for spintronics of molecular devices.
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http://dx.doi.org/10.1038/srep04838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007075PMC
May 2014

A first principles study of novel one-dimensional organic half-metal vanadium-cyclooctatetraene wire.

J Chem Phys 2013 Jul;139(2):024309

School of Physics and Wuhan National High Magnetic Field Center, Huazhong University of Science and Technology, Wuhan 430074, China.

The structural, electronic, and magnetic properties of one-dimensional vanadium-cyclooctatetraene[(V-COT)]∞ wire and sandwich clusters are investigated by means of density functional theory. It is found that the (V-COT)∞ SMW is half-metallic. Through the spin transportation calculations, the system for V-COT clusters coupled to gold electrodes performs nearly perfect spin filters. In addition, the I-V curve shows obviously negative differential resistance effects. These results suggest the potential applications of (V-COT)∞ in spintronics.
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http://dx.doi.org/10.1063/1.4813406DOI Listing
July 2013

The transport properties and new device design: the case of 6,6,12-graphyne nanoribbons.

Nanoscale 2013 May;5(10):4468-75

School of Physics and Wuhan National High Magnetic Field Center, Huazhong University of Science and Technology, Wuhan 430074, China.

By performing first-principle quantum transport calculations, we studied the transport properties of three kinds of 6,6,12-graphyne nanoribbons with different edges and different cutting directions. The nanoribbon with zigzag edges shows metallic properties and the spin-polarized currents show an obvious negative differential resistance effect, the other two nanoribbons terminated by a phenyl ring are semiconductors and spin-unpolarized. We also designed several nanowire devices based on these 6,6,12-graphyne nanoribbons, such as rectifier, spin filter diode, spin FET and spin caloritronics devices. These results indicate that 6,6,12-graphyne is a potential candidate for spintronics and spin caloritronics.
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http://dx.doi.org/10.1039/c3nr00731fDOI Listing
May 2013

Spin seebeck effect and thermal colossal magnetoresistance in graphene nanoribbon heterojunction.

Sci Rep 2013 ;3:1380

School of Physics and Wuhan National High Magnetic Field Center, Huazhong University of Science and Technology, Wuhan 430074, China.

Spin caloritronics devices are very important for future development of low-power-consumption technology. We propose a new spin caloritronics device based on zigzag graphene nanoribbon (ZGNR), which is a heterojunction consisting of single-hydrogen-terminated ZGNR (ZGNR-H) and double-hydrogen-terminated ZGNR (ZGNR-H2). We predict that spin-up and spin-down currents flowing in opposite directions can be induced by temperature difference instead of external electrical bias. The thermal spin-up current is considerably large and greatly improved compared with previous work in graphene. Moreover, the thermal colossal magnetoresistance is obtained in our research, which could be used to fabricate highly-efficient spin caloritronics MR devices.
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http://dx.doi.org/10.1038/srep01380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587885PMC
November 2013

Protective effect of magnolol on lipopolysaccharide-induced acute lung injury in mice.

Inflammation 2012 Dec;35(6):1860-6

Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, China.

Magnolol, a tradition Chinese herb, displays an array of activities including antifungal, antibacterial, and antioxidant effects. To investigate the protective effect of magnolol on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. ALI was induced in mice by intratracheal instillation of LPS (1 mg/kg). The mice received intratracheal instillation of magnolol (5 μg/kg) 30 min before LPS administration. Pulmonary histological changes were evaluated by hematoxylin-eosin stain and lung wet/dry weight ratios were observed. Concentrations of tumor necrosis factor (TNF)-α and interleukin (IL)-1β, and myeloperoxidase (MPO) activity were measured by enzyme-linked immunosorbent assay. Expression of cyclooxygenase (COX)-2 in lung tissues was determined by Western blot analysis. Magnolol pretreatment significantly attenuated the severity of lung injury and inhibited the production of TNF-α and IL-1β in mice with ALI. After LPS administration, the lung wet/dry weight ratios, as an index of lung edema, and MPO activity were also markedly reduced by magnolol pretreatment. The expression of COX-2 was significantly suppressed by magnolol pretreatment. Magnolol potently protected against LPS-induced ALI and the protective effects of magnolol may attribute partly to the suppression of COX-2 expression.
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http://dx.doi.org/10.1007/s10753-012-9507-9DOI Listing
December 2012

Protective effect of nicotine on lipopolysaccharide-induced acute lung injury in mice.

Respiration 2011 21;81(1):39-46. Epub 2010 Jul 21.

Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.

Background: Recently, nicotine administration has been shown to be a potent inhibitor of a variety of innate immune responses, including endotoxin-induced sepsis.

Objective: It was the aim of this study to evaluate the effect of nicotine on attenuating lung injury and improving the survival in mice with lipopolysaccharide (LPS)-induced acute lung injury (ALI).

Methods: ALI was induced in mice by intratracheal instillation of LPS (3 mg/ml). The mice received intratracheal instillation of nicotine (50, 250 and 500 μg/kg) before or after LPS administration. Pulmonary histological changes were evaluated by hematoxylin-eosin stain, and lung wet/dry weight ratios were observed. Concentrations of tumor necrosis factor (TNF)-α, interleukin (IL)-1β and high mobility group box (HMGB)-1, as well as myeloperoxidase (MPO) activity were measured by enzyme-linked immunosorbent assay. The mortality rate was recorded and analyzed by the Kaplan-Meier method.

Results: Nicotine pretreatment significantly attenuated the severity of lung injury and inhibited the production of TNF-α, IL-1β and HMGB-1 in mice with ALI. After LPS administration, the lung wet/dry weight ratios, as an index of lung edema, and MPO activity were also markedly reduced by nicotine pretreatment. Early treatment with a high dose of nicotine (500 μg/kg) after LPS administration decreased the mortality in mice with ALI, even when treatment was started 24 h after LPS administration.

Conclusion: Nicotine attenuated the lung injury and reduced mortality in mice with LPS-induced ALI.
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http://dx.doi.org/10.1159/000319151DOI Listing
April 2011

Prefilming twin-fluid nozzle assisted precipitation method for preparing nanocrystalline HNS and its characterization.

J Hazard Mater 2009 Mar 28;162(2-3):842-7. Epub 2008 May 28.

Chemical Industry and Ecology Institute, North University of China, Taiyuan, Shanxi 030051, China.

The ultra-fine HNS (2,2',4,4',6,6'-hexanitrostilbene) with desired properties is needed for military and civilian applications because of its reliable threshold energy to short impulse shock waves and its excellent thermal and shock stability. This paper reports on prefilming twin-fluid nozzle assisted precipitation (PTFN-P) to obtain ultra-fine HNS explosive with high specific surface area (SSA), high purity, and narrow particle size distribution. The properties of ultra-fine HNS have been confirmed by SEM, BET, HPLC, XRD, DSC and TGA-SDTA. SEM photograph revealed that the PTFN-P process offers ellipsoid crystalline morphology with particle size of 90-150 nm. The BET and Langmuir SSA of nanocrystalline HNS with purity of 99.44 wt.% were determined to be 19.28 m(2)/g and 29.26 m(2)/g, respectively. The XRD peaks of nanocrystalline HNS seemed to have similar diffraction angles as those of synthesized HNS, and the weakening of peak strength was observed apparently. DSC results of the nanocrystalline HNS showed that the exothermic decomposing at the temperature range of 323-398 degrees C. Furthermore, HNS samples were submitted to impact and small scale gap test and the results indicated that nanocrystalline HNS is less sensitive than synthesized HNS (50 microm) to impact and shock stimuli.
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http://dx.doi.org/10.1016/j.jhazmat.2008.05.107DOI Listing
March 2009

Analgesic and anti-inflammatory activities of total extract and individual fractions of Chinese medicinal ants Polyrhachis lamellidens.

Biol Pharm Bull 2005 Jan;28(1):176-80

Department of Traditional Chinese Prescription, China Pharmaceutical University, Nanjing, China.

The ethanol extract of Chinese medicinal ants Polyrhachis lamelliden was evaluated for its analgesic and anti-inflammatory activities in mice. It was shown that the extract significantly inhibited acetic acid-induced writhing response and increased hot-plate pain threshold of mice at doses of 1.5 and 3.0 g crude drug/kg. Meanwhile, the extract significantly inhibited the increase in vascular permeability induced by acetic acid and in ear edema induced by xylene in mice. However, it had no obvious effect on leukocyte migration induced by carboxymethylcellulose sodium (CMC-Na). The ethanol extract suspended in water was partitioned with diethyl ether, ethyl acetate and n-butanol successively to yield four fractions including water fraction. Among these fractions, diethyl ether and ethyl acetate fractions were found to increase hot-plate pain threshold and to inhibit acetic acid-induced writhing response in mice. Water fractions markedly inhibited acetic acid-induced writhing response and reduced the dye leakage to the peritoneal cavity induced by acetic acid and ear edema induced by xylene. These results suggest that P. lamellidens presents remarkable analgesic and anti-inflammatory activity, which supported the traditional use of the medicinal ants in the treatment of various diseases associated with inflammation. The diethyl ether fraction has greater contribution to the overall analgesic activity, whereas the water fraction showed the greatest anti-inflammatory and peripheral analgesic activities.
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http://dx.doi.org/10.1248/bpb.28.176DOI Listing
January 2005

Acupuncture treatment for 34 cases of epiphora with dysfunction of lacrimal duct.

J Tradit Chin Med 2002 Mar;22(1):31-2

First Clinical College, Nanjing University of Traditional Chinese Medicine, and Pharmacy, Nanjing 210029.

We have treated 34 cases of epiphora due to dysfunction of the lacrimal duct with a warm needle puncturing at the Jingming (UB 1) point. The effect was significantly better than that of the control group treated with lacrimal duct irrigation and norflaxacin eye drops (a total effective rate of 91.07% vs. 54.29%).
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March 2002