Yumei Leng

Yumei Leng

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Yumei Leng

Yumei Leng

Publications by authors named "Yumei Leng"

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15Publications

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Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.

Mol Cell 2019 03 24;73(5):885-899.e6. Epub 2019 Jan 24.

Howard Hughes Medical Institute, Department of Genetics, Ludwig Center, Harvard Medical School, Boston, MA 02115, USA; Division of Genetics, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.12.008DOI Listing
March 2019

Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns.

Cell 2018 04 22;173(2):499-514.e23. Epub 2018 Mar 22.

Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.02.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643283PMC
April 2018

A genetic interaction analysis identifies cancer drivers that modify EGFR dependency.

Genes Dev 2017 01 6;31(2):184-196. Epub 2017 Feb 6.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Department of Genetics, Program in Virology, Howard Hughes Medical Institute, Harvard University Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1101/gad.291948.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322732PMC
January 2017

A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription Factors.

Cell Rep 2015 Jun 21;11(9):1486-500. Epub 2015 May 21.

Department of Genetics, Harvard University Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute; Division of Genetics, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.04.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464939PMC
June 2015

A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal.

Genes Dev 2009 Apr;23(7):837-48

Howard Hughes Medical Institute, Department of Genetics, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1101/gad.1769609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666338PMC
April 2009

SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation.

Nature 2008 Mar;452(7185):370-4

Howard Hughes Medical Institute, Department of Genetics, Harvard Partners Center for Genetics and Genomics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature06780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688689PMC
March 2008

Nuclear import of the MUC1-C oncoprotein is mediated by nucleoporin Nup62.

J Biol Chem 2007 Jul 11;282(27):19321-30. Epub 2007 May 11.

Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M703222200DOI Listing
July 2007

A genetic screen for candidate tumor suppressors identifies REST.

Cell 2005 Jun;121(6):837-48

Howard Hughes Medical Institute, Department of Genetics, Harvard Partners Center for Genetics and Genomics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/j.cell.2005.03.033DOI Listing
June 2005

Ubiquitination and degradation of the Arg tyrosine kinase is regulated by oxidative stress.

Oncogene 2005 Apr;24(15):2433-40

Beijing Institute of Biotechnology, Beijing 100850, China.

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http://dx.doi.org/10.1038/sj.onc.1208454DOI Listing
April 2005

Glutathione peroxidase 1 is regulated by the c-Abl and Arg tyrosine kinases.

J Biol Chem 2003 Oct 31;278(41):39609-14. Epub 2003 Jul 31.

Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M305770200DOI Listing
October 2003

Catalase is regulated by ubiquitination and proteosomal degradation. Role of the c-Abl and Arg tyrosine kinases.

Biochemistry 2003 Sep;42(35):10348-53

Beijing Institute of Biotechnology, Beijing 100850, Peoples Republic of China.

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http://dx.doi.org/10.1021/bi035023fDOI Listing
September 2003

Catalase activity is regulated by c-Abl and Arg in the oxidative stress response.

J Biol Chem 2003 Aug 30;278(32):29667-75. Epub 2003 May 30.

Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M301292200DOI Listing
August 2003

Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response.

J Biol Chem 2003 Apr 4;278(15):12961-7. Epub 2003 Feb 4.

Beijing Institute of Biotechnology, Beijing 100850, China.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M300058200
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http://dx.doi.org/10.1074/jbc.M300058200DOI Listing
April 2003