Publications by authors named "Yulin Wang"

270 Publications

Hypoglycemia and jaundice in newborns with pituitary stalk interruption syndrome.

Medicine (Baltimore) 2021 May;100(19):e25843

Department of Paediatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan.

Abstract: Pituitary stalk interruption syndrome (PSIS) is a rare disease associated with either isolated growth hormone deficiency (GHD) or combined pituitary hormone deficiency (CPHD). In older children and adults, most patients experience short stature or hypogonadism. Neonatal PSIS is extremely rare and is difficult to recognize due to absence of dwarfism. However, when this condition occurs in newborns, it is often life-threatening. Here, we collected patients with neonatal PSIS to clarify its characteristics to improve its early diagnosis.The patients included in this study were treated at the pediatric endocrine department of Shandong Provincial Hospital from January 2017 to July 2020. We obtained the clinical characteristics, endocrine hormone levels, pituitary magnetic resonance imaging (MRI) and further genetic data for all the patients. Hormone therapy was first given at the time of diagnosis, and the patients received regular follow-up.Three neonatal patients were identified in our clinic. The characteristics of these patients included hypoglycemia and jaundice, as well as CPHD, which included features such as micropenis and hypothyroidism. Genetic etiology was still hard to discover. All the patients responded well to alternative therapy, and the longest follow-up period was 3 years. Regular replacement ensures good prognosis.Sustained hypoglycemia and jaundice in newborns, indicate the presentation of PSIS. Early recognition is of great importance to avoid a life-threatening crisis.
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http://dx.doi.org/10.1097/MD.0000000000025843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133236PMC
May 2021

Compressed sensorimotor-to-transmodal hierarchical organization in schizophrenia.

Psychol Med 2021 Jun 8:1-14. Epub 2021 Jun 8.

The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China, China.

Background: Schizophrenia has been primarily conceptualized as a disorder of high-order cognitive functions with deficits in executive brain regions. Yet due to the increasing reports of early sensory processing deficit, recent models focus more on the developmental effects of impaired sensory process on high-order functions. The present study examined whether this pathological interaction relates to an overarching system-level imbalance, specifically a disruption in macroscale hierarchy affecting integration and segregation of unimodal and transmodal networks.

Methods: We applied a novel combination of connectome gradient and stepwise connectivity analysis to resting-state fMRI to characterize the sensorimotor-to-transmodal cortical hierarchy organization (96 patients v. 122 controls).

Results: We demonstrated compression of the cortical hierarchy organization in schizophrenia, with a prominent compression from the sensorimotor region and a less prominent compression from the frontal-parietal region, resulting in a diminished separation between sensory and fronto-parietal cognitive systems. Further analyses suggested reduced differentiation related to atypical functional connectome transition from unimodal to transmodal brain areas. Specifically, we found hypo-connectivity within unimodal regions and hyper-connectivity between unimodal regions and fronto-parietal and ventral attention regions along the classical sensation-to-cognition continuum (voxel-level corrected, p < 0.05).

Conclusions: The compression of cortical hierarchy organization represents a novel and integrative system-level substrate underlying the pathological interaction of early sensory and cognitive function in schizophrenia. This abnormal cortical hierarchy organization suggests cascading impairments from the disruption of the somatosensory-motor system and inefficient integration of bottom-up sensory information with attentional demands and executive control processes partially account for high-level cognitive deficits characteristic of schizophrenia.
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http://dx.doi.org/10.1017/S0033291721002129DOI Listing
June 2021

The first case study of wastewater-based epidemiology of COVID-19 in Hong Kong.

Sci Total Environ 2021 May 24;790:148000. Epub 2021 May 24.

Environmental Microbiome Engineering and Biotechnology Laboratory, Department of Civil Engineering, The University of Hong Kong, Pok Fu Lam Road, Hong Kong SAR, China. Electronic address:

Early detection and surveillance of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) virus are key pre-requisites for the effective control of coronavirus disease (COVID-19). So far, sewage testing has been increasingly employed as an alternative surveillance tool for this disease. However, sampling site characteristics impact the testing results and should be addressed in the early use stage of this emerging tool. In this study, we implemented the sewage testing for SARS-CoV-2 virus across sampling sites with different sewage system characteristics. We first validated a testing method using "positive" samples from a hospital treating COVID-19 patients. This method was used to test 107 sewage samples collected during the third wave of the COVID-19 outbreak in Hong Kong (from June 8 to September 29, 2020), covering sampling sites associated with a COVID-19 hospital, public housing estates, and conventional sewage treatment facilities. The highest viral titer of 1975 copy/mL in sewage was observed in a sample collected from the isolation ward of the COVID-19 hospital. Sewage sampling at individual buildings detected the virus 2 days before the first cases were identified. Sequencing of the detected viral fragment confirmed an identical nucleotide sequence to that of the SARS-CoV-2 isolated from human samples. The virus was also detected in sewage treatment facilities, which serve populations of approximately 40,000 to more than one million people.
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http://dx.doi.org/10.1016/j.scitotenv.2021.148000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8142803PMC
May 2021

Short sleep duration increases the risk of hyperuricemia among Chinese adults: findings from the China Health and Nutrition Survey.

Sleep Med 2021 May 21;84:40-45. Epub 2021 May 21.

Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China; Shanghai Medical Center of Kidney Disease, Shanghai, 200032, China; Kidney and Dialysis Institute of Shanghai, Shanghai, 200032, China; Shanghai Key Laboratory of Kidney and Blood Purification, Shanghai, 200032, China. Electronic address:

Study Objectives: Hyperuricemia is a growing public health problem with its increasing prevalence. Few studies have investigated the association between sleep duration and hyperuricemia. The objective of this study is to explore whether short sleep duration is an independent risk factor of hyperuricemia in Chinese adults.

Methods: The data we analyzed was extracted from the 2009 wave of the China Health and Nutrition Survey. The population we analyzed included 8289 participants aged 18 years or older with sleep of 5-10 h per 24 h. We categorized the population into three groups by sleep duration: 5-6 h (short sleeper),7-8 h (regular sleeper), and 9-10 h (long sleeper). Hyperuricemia was defined as serum uric acid ≥7 mg/dL in men and ≥6 mg/dL in women.

Results: Among the three groups, 9.8% were short sleepers, 68.4% were regular sleepers and 21.8% were long sleepers. The prevalences of hyperuricemia were 19.5%,15.2% and 15.5% respectively. The risks of hyperuricemia in regular and long sleep groups were lower than short sleep group, and the association remained after adjusting for indexes including age, gender, chronic kidney disease, hypertension, diabetes mellitus, high low-density lipoprotein cholesterol (LDL-c), and obesity. In subgroup analysis, we found the association was still observed in participants without hypertension, diabetes mellitus or obesity.

Conclusions: Our findings suggest that short sleep duration is associated with higher risk of hyperuricemia independently of cardiometabolic risk factors, especially in individuals without traditional hyperuricemia risk factors.
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http://dx.doi.org/10.1016/j.sleep.2021.05.014DOI Listing
May 2021

Erratum to "Punicalin Alleviates OGD/R-Triggered Cell Injury via TGF--Mediated Oxidative Stress and Cell Cycle in Neuroblastoma Cells SH-SY5Y.

Evid Based Complement Alternat Med 2021 19;2021:9840240. Epub 2021 Apr 19.

Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

[This corrects the article DOI: 10.1155/2021/6671282.].
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http://dx.doi.org/10.1155/2021/9840240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100407PMC
April 2021

Global Research Trends of Ferroptosis: A Rapidly Evolving Field With Enormous Potential.

Front Cell Dev Biol 2021 29;9:646311. Epub 2021 Apr 29.

Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China.

Ferroptosis is a newly proposed form of programmed cell death, and accumulating evidence suggests that it plays an essential role in the development of multiple diseases, especially cancers and neurodegenerative diseases. Since officially named in 2012, research on ferroptosis has grown rapidly. There are previous reviews focused on the research progress of ferroptosis from a certain aspect, but no bibliometric studies summarizing this field as a whole. This study aimed to assess the scientific output and activity regarding ferroptosis research from a global perspective. Publications related to ferroptosis from 2012 to 2020 were identified and selected from the Web of Science Core Collection. Excel 2019 and GraphPad Prism 8.0 was used to analyze quantitative variables including number of publications and citations, H-index, and journal citation reports. VOS viewer and CiteSpace were used to perform co-authorship, co-citation, and co-occurrence analysis of countries/institutes/authors/keywords. A total of 1,285 publications on ferroptosis research were identified. The literature on ferroptosis had been continuously growing since 2012, and the expansion might continue at a rapid pace in the following years. China contributed the greatest proportion (43.74%) of ferroptosis publications, and the United States ranked first in the number of citation frequency (20,980 times) and H-index (70). B. R. Stockwell, D. L. Tang, and R. Kang were key researchers. The journal published the highest number of articles, with 42 articles. All the keywords could be divided into two clusters: cluster 1 (pathway and mechanism) and cluster 2 (treatment and effect). In terms of potential hotspots, keywords with the strong bursts and still ongoing recently were "neurodegeneration" (2017-2020), "chemotherapy" (2017-2020), "NF-kappa B" (2017-2020), and "photodynamic therapy" (2018-2020). There will be a dramatically increasing number of publications on ferroptosis research based on the current global trends. China has made significant progress in ferroptosis research, but the United States is actually dominated in this field. More focus will be placed on neurodegeneration, chemotherapy, nuclear factor κB, and photodynamic therapy, which may be the next popular topics in ferroptosis research.
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http://dx.doi.org/10.3389/fcell.2021.646311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116802PMC
April 2021

Multistructured Electrospun Nanofibers for Air Filtration: A Review.

ACS Appl Mater Interfaces 2021 May 11;13(20):23293-23313. Epub 2021 May 11.

Joint Laboratory of Advanced Biomedical Materials (NFU-UGent) College of Chemical Engineering Nanjing Forestry University (NFU), Nanjing 210037, P. R. China.

Air filtration materials (AFMs) have gradually become a research hotspot on account of the increasing attention paid to the global air quality problem. However, most AFMs cannot balance the contradiction between high filtration efficiency and low pressure drop. Electrospinning nanofibers have a large surface area to volume ratio, an adjustable porous structure, and a simple preparation process that make them an appropriate candidate for filtration materials. Therefore, electrospun nanofibers have attracted increased attention in air filtration applications. In this paper, first, the preparation methods of high-performance electrospun air filtration membranes (EAFMs) and the typical surface structures and filtration principles of electrospun fibers for air filtration are reviewed. Second, the research progress of EAFMs with multistructures, including nanoprotrusion, wrinkled, porous, branched, hollow, core-shell, ribbon, beaded, nets structure, and the application of these nanofibers in air filtration are summarized. Finally, challenges with the fabrication of EAFMs, limitations of their use, and trends for future developments are presented.
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http://dx.doi.org/10.1021/acsami.1c06520DOI Listing
May 2021

Discovering Panel of Autoantibodies for Early Detection of Lung Cancer Based on Focused Protein Array.

Front Immunol 2021 23;12:658922. Epub 2021 Apr 23.

Department of Oncology, Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.

Substantial studies indicate that autoantibodies to tumor-associated antigens (TAAbs) arise in early stage of lung cancer (LC). However, since single TAAbs as non-invasive biomarkers reveal low diagnostic performances, a panel approach is needed to provide more clues for early detection of LC. In the present research, potential TAAbs were screened in 150 serum samples by focused protein array based on 154 proteins encoded by cancer driver genes. Indirect enzyme-linked immunosorbent assay (ELISA) was used to verify and validate TAAbs in two independent datasets with 1,054 participants (310 in verification cohort, 744 in validation cohort). In both verification and validation cohorts, eight TAAbs were higher in serum of LC patients compared with normal controls. Moreover, diagnostic models were built and evaluated in the training set and the test set of validation cohort by six data mining methods. In contrast to the other five models, the decision tree (DT) model containing seven TAAbs (TP53, NPM1, FGFR2, PIK3CA, GNA11, HIST1H3B, and TSC1), built in the training set, yielded the highest diagnostic value with the area under the receiver operating characteristic curve (AUC) of 0.897, the sensitivity of 94.4% and the specificity of 84.9%. The model was further assessed in the test set and exhibited an AUC of 0.838 with the sensitivity of 89.4% and the specificity of 78.2%. Interestingly, the accuracies of this model in both early and advanced stage were close to 90%, much more effective than that of single TAAbs. Protein array based on cancer driver genes is effective in screening and discovering potential TAAbs of LC. The TAAbs panel with TP53, NPM1, FGFR2, PIK3CA, GNA11, HIST1H3B, and TSC1 is excellent in early detection of LC, and they might be new target in LC immunotherapy.
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http://dx.doi.org/10.3389/fimmu.2021.658922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102818PMC
April 2021

Bibliometric Analysis of Global Research Trends on Ultrasound Microbubble: A Quickly Developing Field.

Front Pharmacol 2021 22;12:646626. Epub 2021 Apr 22.

Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China.

Microbubbles are widely used as highly effective contrast agents to improve the diagnostic capability of ultrasound imaging. Mounting evidence suggests that ultrasound coupled with microbubbles has promising therapeutic applications in cancer, cardiovascular, and neurological disorders by acting as gene or drug carriers. The aim of this study was to identify the scientific output and activity related to ultrasound microbubble through bibliometric approaches. The literature related to ultrasound microbubble published between 1998 and 2019 was identified and selected from the Science Citation Index Expanded of Web of Science Core Collection on February 21, 2021. The Scopus database was also searched to validate the results and provided as supplementary material. Quantitative variables including number of publications and citations, H-index, and journal citation reports were analyzed by using Microsoft Excel 2019 and GraphPad Prism 8.0 software. VOS viewer and CiteSpace V were used to perform coauthorship, citation, co-citation, and co-occurrence analysis for countries/regions, institutions, authors, and keywords. A total of 6088 publications from the WoSCC were included. The United States has made the largest contribution in this field, with the majority of publications (2090, 34.3%), citations (90,741, 46.6%), the highest H-index (138), and close collaborations with China and Canada. The most contributive institution was the University of Toronto. Professors De Jong N and Dayton P A have made great achievements in this field. However, the research cooperation between institutions and authors was relatively weak. All the studies could be divided into four clusters: "ultrasound diagnosis study," "microbubbles' characteristics study," "gene therapy study," and "drug delivery study." The average appearing years (AAY) of keywords in the cluster "drug delivery study" was more recent than other clusters. For promising hot spots, "doxorubicin" showed a relatively latest AAY of 2015.49, followed by "nanoparticles" and "breast cancer." There has been an increasing amount of scientific output on ultrasound microbubble according to the global trends, and the United States is staying ahead in this field. Collaboration between research teams still needs to be strengthened. The focus gradually shifts from "ultrasound diagnosis study" to "drug delivery study." It is recommended to pay attention to the latest hot spots, such as "doxorubicin," "nanoparticles," and "breast cancer."
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http://dx.doi.org/10.3389/fphar.2021.646626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101552PMC
April 2021

Effects of Health Qigong Exercises on Physical Function on Patients with Parkinson's Disease.

J Multidiscip Healthc 2021 28;14:941-950. Epub 2021 Apr 28.

Department of Neurology, Aerospace Central Hospital, Beijing, 100049, People's Republic of China.

Purpose: To measure motor function improvements in patients with Parkinson's disease (PD) using Health Qigong exercises.

Patients And Methods: Fifty-two PD patients (Hoehn and Yahr stages I to IV) were randomly divided into experimental and control groups. Twenty-six PD patients in the experimental group were intervened with routine medicine and fitness Qigong exercise. The other 26 PD patients as the control group were treated only with regular medication. Twelve-week intervention had been conducted for the study, and participants completed the scheduled exercises 4 times per week for 60 minutes each time. Data which included the one-legged blind balance, physical coordination, and gait was collected before, during, and after the intervention. Comparisons were made between the experimental and control groups through the repeated measures analysis of variance.

Results: A total of 40 participants (77% response rate) completed the study. There was no significant difference in baseline data. After 12 weeks of Health Qigong therapy, the length of time the one-legged blind balance test had increased (P < 0.01), and the time it took to TUG test was reduced (P < 0.01). Joint range of motion and gait significantly improved. The control group's there were no significant differences in the above variables, except for joint range of motion, which decreased.

Conclusion: Health Qigong exercises can significantly improve physical functions in patients with PD, especially for the balance ability, gait, joint range of motion in patients with PD. It can reduce their activity risk factor and improve their quality of life.
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http://dx.doi.org/10.2147/JMDH.S303945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8091455PMC
April 2021

An Improved Similarity-Based Clustering Algorithm for Multi-Database Mining.

Entropy (Basel) 2021 Apr 29;23(5). Epub 2021 Apr 29.

School of Computer Science, Wuhan University, Wuhan 430072, China.

Clustering algorithms for multi-database mining (MDM) rely on computing (n2-n)/2 pairwise similarities between multiple databases to generate and evaluate m∈[1,(n2-n)/2] candidate clusterings in order to select the ideal partitioning that optimizes a predefined goodness measure. However, when these pairwise similarities are distributed around the mean value, the clustering algorithm becomes indecisive when choosing what database pairs are considered eligible to be grouped together. Consequently, a trivial result is produced by putting all the databases in one cluster or by returning singleton clusters. To tackle the latter problem, we propose a learning algorithm to reduce the fuzziness of the similarity matrix by minimizing a weighted binary entropy loss function via gradient descent and back-propagation. As a result, the learned model will improve the certainty of the clustering algorithm by correctly identifying the optimal database clusters. Additionally, in contrast to gradient-based clustering algorithms, which are sensitive to the choice of the learning rate and require more iterations to converge, we propose a learning-rate-free algorithm to assess the candidate clusterings generated on the fly in fewer upper-bounded iterations. To achieve our goal, we use coordinate descent (CD) and back-propagation to search for the optimal clustering of the multiple database in a way that minimizes a convex clustering quality measure L(θ) in less than (n2-n)/2 iterations. By using a max-heap data structure within our CD algorithm, we optimally choose the largest weight variable θp,q(i) at each iteration such that taking the partial derivative of L(θ) with respect to θp,q(i) allows us to attain the next steepest descent minimizing L(θ) without using a learning rate. Through a series of experiments on multiple database samples, we show that our algorithm outperforms the existing clustering algorithms for MDM.
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http://dx.doi.org/10.3390/e23050553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144976PMC
April 2021

Multifunctional Applications of Blow-Spinning Structured Fibrous Membranes in Water Purification.

ACS Appl Mater Interfaces 2021 May 4;13(19):22874-22883. Epub 2021 May 4.

Joint Laboratory of Advanced Biomedical Materials (NFU-UGent), Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, P. R. China.

With increasing water pollution and human health problems caused by oily wastewater, the fabrication of oil-water separation materials has become an urgent task. However, most of the reported materials have a single function and poor performance. In this paper, a multifunctional zinc oxide/polyaniline/polyacrylonitrile (ZnO/PANI/PAN) nanofibrous membrane with needle-like ZnO nanorods was prepared by synthesis of PANI and a hydrothermal reaction on a highly stable self-standing PAN blow-spinning fibrous membrane. Due to the electronic synergistic effect of ZnO and PANI, the fibrous membrane exhibits excellent antibacterial activity and visible-light degradation ability of organic dyes. Moreover, the micro-/nanosized pores of the ZnO/PANI/PAN fibrous membranes also guarantee its excellent emulsion separation performance, including an ultrahigh surfactant-free emulsion permeate flux (∼8597.40 L/(m h)), ultrahigh surfactant-stabilized emulsion permeate flux (∼2253.50 L/(m h)), and excellent separation efficiency (above 99%). Furthermore, the composite membrane maintains stable underwater superoleophobicity and hydrophilicity under adverse conditions, shows good biological safety, and is harmless to the water environment. These excellent properties endow the ZnO/PANI/PAN nanofibrous membranes with great potential in treating oily wastewater.
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http://dx.doi.org/10.1021/acsami.1c05667DOI Listing
May 2021

Ameliorative role of SIRT1 in peritoneal fibrosis: an in vivo and in vitro study.

Cell Biosci 2021 Apr 27;11(1):79. Epub 2021 Apr 27.

Department of Nephropathy, The First Affiliated Hospital of Zhengzhou University, No. 1 East Jianshe Road, Zhengzhou, 450052, Henan, China.

Background: Peritoneal fibrosis is one of the major complications induced by peritoneal dialysis (PD). Damaged integrity and function of peritoneum caused by peritoneal fibrosis not only limits the curative efficacy of PD and but affects the prognosis of patients. However, the detailed mechanisms underlying the process remain unclear and therapeutic strategy targeting TGF-β is deficient. Transforming growth factor-β (TGF-β) signaling participates in the progression of peritoneal fibrosis through enhancing mesothelial-mesenchymal transition of mesothelial cells.

Methods: The study aims to demonstrate the regulatory role of Sirtuin1 (SIRT1) to the TGF-β signaling mediated peritoneal fibrosis. SIRT1 mice were used to establish animal model. Masson's staining and peritoneal equilibration assay were performed to evaluate the degree of peritoneal fibrosis. QRT-PCR assays were used to estimate the RNA levels of Sirt1 and matrix genes related to peritoneal fibrosis, and their protein levels were examined by Western blot assays.

Results: SIRT1 significantly decreased in vivo post PD treatment. SIRT1 knockout exacerbated peritoneal fibrosis both in vivo and vitro. Overexpression of SIRT1 efficiently inhibited peritoneal fibrosis by inhibiting the peritoneal inflammation and the activation of TGF-β signaling.

Conclusion: SIRT1 ameliorated peritoneal fibrosis both in vivo and in vitro through inhibiting the expression of protein matrix induced by TGF-β signaling.
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http://dx.doi.org/10.1186/s13578-021-00591-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077771PMC
April 2021

A Longitudinal Study of White Matter Functional Network in Mild Traumatic Brain Injury.

J Neurotrauma 2021 May 28. Epub 2021 May 28.

Key Laboratory for Artificial Intelligence and Cognitive Neuroscience of Language, Xi'an International Studies University, Xi'an, China.

Some patients after mild traumatic brain injury (mTBI) experience microstructural damages in the long-distance white matter (WM) connections, which disrupts the functional connectome of large-scale brain networks that support cognitive function. Patterns of WM structural damage following mTBI were well documented using diffusion tensor imaging (DTI). However, the functional organization of WM and its association with gray matter functional networks (GM-FNs) and its DTI metrics remain unknown. The present study adopted resting-state functional magnetic resonance imaging to explore WM functional properties in mTBI patients (108 acute patients, 48 chronic patients, 46 healthy controls [HCs]). Eleven large-scale WM functional networks (WM-FNs) were constructed by the k-means clustering algorithm of voxel-wise WM functional connectivity (FC). Compared with HCs, acute mTBI patients observed enhanced FC between inferior fronto-occipital fasciculus (IFOF) WM-FN and primary sensorimotor WM-FNs, and cortical primary sensorimotor GM-FNs. Further, acute mTBI patients showed increased DTI metrics (mean diffusivity, axial diffusivity, and radial diffusivity) in deep WM-FNs and higher-order cognitive WM-FNs. Moreover, mTBI patients demonstrated full recovery of FC and partial recovery of DTI metrics in the chronic stage. Additionally, enhanced FC between IFOF WM-FN and anterior cerebellar GM-FN was correlated with impaired information processing speed. Our findings provide novel evidence for functional and structural alteration of WM-FNs in mTBI patients. Importantly, the convergent damage of the IFOF network might imply its crucial role in our understanding of the pathophysiology mechanism of mTBI patients.
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http://dx.doi.org/10.1089/neu.2021.0017DOI Listing
May 2021

Worldwide research tendency and hotspots on hip fracture: a 20-year bibliometric analysis.

Arch Osteoporos 2021 04 17;16(1):73. Epub 2021 Apr 17.

Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, 300070, China.

We analyzed the overall knowledge structure, development trends, and research hotspots of 7684 publications related to hip fracture through the bibliometric method. Our results indicate this area has received more and more attention from researchers. Prevention of complications will be the focus of future studies.

Introduction: Hip fracture is an international public health problem, with high morbidity, mortality, and associated health care costs. Research on hip fracture has been developed rapidly in recent years, but no bibliometric studies have been performed. We aimed to identify the publication changes in scientific output relating to hip fracture over the past two decades.

Methods: The scientific output relating to hip fracture from 2000 to 2019 was identified and selected from the Web of Science Core Collection. Excel 2019 was used to summarize the quantitative indicators including publication number, citations, H-index, journal's impact factors, and journal citation reports. VOS viewer and CiteSpace software tools were used for co-authorship, citation, co-citation, and co-occurrence analyses between countries, institutions, journals, authors, references, and keywords. Data were analyzed on November 13, 2020.

Results: A total of 7684 publications were extracted. The USA was the leading contributor in this field with the largest publications (1876, 24.41%), the most citations (75,423 times), and the highest H-index (124). The number of publications in the Western European region is 1.82 times higher than that of North America region, and 3.59 times that of Eastern Asia region. The most productive institutions on hip fracture were University of Maryland (160). Injury (506) had the highest number of publications, while Osteoporosis International (20,483 times) was the most co-cited journal. Magaziner J and Parker MJ were the key researchers. The keywords were stratified into five clusters: cluster 1 ("operative approaches study"), cluster 2 ("rehabilitation study"), cluster 3 ("osteoporosis study"), cluster 4 ("outcomes and complications study"), and cluster 5 ("epidemiology study"). For hotspots, "tranexamic acid" showed a relatively latest average appearing years of 2017.52, followed by "30-day-mortality," "readmission," and "length of stay."

Conclusions: There will be an increasing number of publications on the hip fracture research based on the current global trends, and the USA stays ahead in this field. In terms of region, Western Europe had the greater impact than North America. It is recommended to pay attention to the promising hotspots, such as tranexamic acid, 30-day-mortality, readmission, and length of stay.
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http://dx.doi.org/10.1007/s11657-021-00929-2DOI Listing
April 2021

High performance, environmentally friendly and sustainable nanofiber membrane filter for removal of particulate matter 1.0.

J Colloid Interface Sci 2021 Sep 2;597:48-55. Epub 2021 Apr 2.

Joint Laboratory of Advanced Biomedical Materials (NFU-UGent) Nanjing Forestry, University (NFU), Nanjing 210037, China. Electronic address:

Particulate matter (PM) air pollution is becoming more and more serious and dangerous to public health, especially in developing countries where industrialization is accelerating. The use of electrospun membrane-based materials for air filtration is a widespread and effective way to help individuals avoid air pollution. However, most electrospun membrane preparation processes require the use of organic solvents, resulting in secondary environmental pollution. In this study, an environmentally friendly polyvinyl alcohol (PVA) - tannic acid (TA) composite nanofiber membrane filter was prepared by the green electrospinning and the physical cross-linking method. The filtration efficiency of the membrane filter for PM reached 99.5%, and the pressure drop was only 35 Pa. In addition, due to the existence of intermolecular hydrogen bond between PVA and TA, the mechanical properties of the nanofiber membrane were improved to meet the requirements of practical application of the filter. Therefore, the PVA-TA composite nanofiber membrane is expected to provide a solution for the development of efficient and environmentally friendly air filter.
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http://dx.doi.org/10.1016/j.jcis.2021.03.174DOI Listing
September 2021

Septuagenarians with hypertrophic obstructive cardiomyopathy undergoing myectomy: the experience of a single center.

Surg Today 2021 Apr 13. Epub 2021 Apr 13.

Shanghai Municipal Institute for Cardiovascular Diseases, 1609 Xietu Road, Shanghai, 200032, China.

Purposes: A previous study reported that the ventricular septum is more fragile in geriatric patients, and thus myectomy may expose geriatric patients to a higher risk of serious complications. This single-center study evaluates the impacts of the advanced age on the results following myectomy for symptomatic hypertrophic obstructive cardiomyopathy (HOCM).

Methods: All eligible patients were divided into an elderly group (septuagenarians, n = 35) and a control group (patients under 70 years, n = 197). The patients were followed up for a median of 10 months. Thereafter, the perioperative and follow-up results were compared.

Results: Thirteen patients (8.6% for the elderly group and 5.1% for the control group, p = 0.422) underwent immediate repeat surgery. Surgical mortality did not differ between groups (0 vs. 0.5%, p > 0.05). There was no significant difference in the incidence of complete atrioventricular block between groups (5.7 vs. 3.0%, p = 0.346). No follow-up deaths occurred in either group. The maximum gradients at the latest follow-up were significantly lower than the preoperative values in either group. Additionally, grouping (septuagenarians vs. patients under 70 years of age) was not an independent risk factor for surgical complications and results via multivariable logistic regression.

Conclusions: Septuagenarians with HOCM may obtain favorable results following septal myectomy, the same as did HOCM patients under 70 years of age.
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http://dx.doi.org/10.1007/s00595-021-02272-yDOI Listing
April 2021

Selective enrichment of comammox from activated sludge using antibiotics.

Water Res 2021 Jun 24;197:117087. Epub 2021 Mar 24.

Environmental Microbiome Engineering and Biotechnology Laboratory, The University of Hong Kong, Hong Kong SAR, China; Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhuhai, Guangdong, China. Electronic address:

While the ubiquitous presence of comammox in engineered systems provides the foundation of developing a novel biological nitrogen removal process, factors contributing to the comammox dynamics in engineered systems have not been well resolved. Here, we investigate the long-term effects of ten different antibiotics on microbial community dynamics in activated sludge and the results show that both types and concentrations of antibiotics affect the taxonomic composition of nitrifiers, including comammox, ammonia-oxidizing bacteria, and canonical nitrite-oxidizing bacteria. Specifically, phylogenetically different comammox Nitrospira were selectively enriched by four types of antibiotics (i.e., ampicillin, kanamycin, lincomycin, and trimethoprim). Comparative genomic analysis of the four newly identified comammox clade A Nitrospira revealed that the comammox enriched by antibiotics shared the conserved key metabolic potentials, such as carbon fixation, complete ammonia oxidation, and utilization of hydrogen as alternative electron donors, among the known comammox organisms. Comammox strains enriched in this study also encoded genes involved in formate and cyanate metabolism that were recently reported in comammox clade A organisms from wastewater treatment systems. Our findings highlight that the comammox in activated sludge ecosystems possess high metabolic versatility than previously recognized and could be selectively enriched by some antibiotics.
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http://dx.doi.org/10.1016/j.watres.2021.117087DOI Listing
June 2021

Drought Resistance in Qingke Involves a Reprogramming of the Phenylpropanoid Pathway and UDP-Glucosyltransferase Regulation of Abiotic Stress Tolerance Targeting Flavonoid Biosynthesis.

J Agric Food Chem 2021 Apr 26;69(13):3992-4005. Epub 2021 Mar 26.

College of Tropical Crops, Hainan University, Haikou 570228, China.

Tibetan hulless barley (qingke) is an important food crop in the Tibetan plateau. However, it often suffers from drought stress resulting in reduction of food production because of the extreme plateau environment. To elucidate the molecular mechanisms underlying the drought resistance of qingke, the transcriptomic and metabolomic responses of drought-sensitive (D) and drought-resistant (XL) accessions were characterized in experiments with a time course design. The phenylpropanoid pathway was reprogrammed by downregulating the lignin pathway and increasing the biosynthesis of flavonoids and anthocyanins, and this regulation improved plant tolerance for drought stress. Besides, flavonoid glycosides have induced accumulation of metabolites that participated in drought stress resistance. 711410 exhibited the activity of wide-spectrum glucosyltransferase and mediated flavonoid glycosylation to enhance drought stress resistance. Overall, the findings provide insights into the regulatory mechanism underlying drought stress tolerance associated with metabolic reprogramming. Furthermore, the flavonoid-enriched qingke is more tolerant to drought stress and can be used as a functional food to benefit human health.
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http://dx.doi.org/10.1021/acs.jafc.0c07810DOI Listing
April 2021

Surgical Septal Myectomy for the Treatment of Residual Left Ventricular Outflow Tract Obstruction Following Failed Alcohol Septal Ablation.

Int Heart J 2021 Mar 17;62(2):329-336. Epub 2021 Mar 17.

Shanghai Municipal Institute for Cardiovascular Diseases.

The reasons of residual left ventricular outflow tract (LVOT) obstruction following alcohol septal ablation (ASA) remain unclear, and outcomes of myectomy following failed ASA remain underreported.Thirteen symptomatic patients (10 women, a median age of 60.0 years) who underwent septal myectomy following failed ASA were reviewed. The patients were followed up for a median of 6 months. The clinical characteristics and outcomes of these patients were analyzed and were compared with those of 178 patients who underwent isolated myectomy without previous ASA at our institution during the same period.In the first ASA procedure, the median number of septal perforator arteries injected was 1.0 with the median value of peak creatine kinase following ablation of 978.5 U/L.Uncontrollable extent and location of infarcted myocardium caused by ablation and mitral subvalvular anomalies were found in four (30.8%) and seven (53.8%) patients, respectively. No operative or follow-up deaths occurred. The median maximum LVOT gradients fell from preoperative 112.0 to 8.5 mmHg at follow-up (P < 0.001). Compared with controls, patients with failed ASA had a higher proportion of mitral subvalvular anomalies (53.8% versus 13.5%, P = 0.001) and developed a higher incidence of complete atrioventricular block following myectomy (15.4% versus 1.7%, P = 0.038).Low institutional or operator experience with ablation, uncontrollable extent and location of infarcted myocardium caused by ablation, and mitral subvalvular anomalies may be reasons for failed ASA. Surgical myectomy for the treatment of residual LVOT obstruction after unsuccessful ASA may be associated with favorable results.
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http://dx.doi.org/10.1536/ihj.20-428DOI Listing
March 2021

Association between urbanisation and the risk of hyperuricaemia among Chinese adults: a cross-sectional study from the China Health and Nutrition Survey (CHNS).

BMJ Open 2021 03 10;11(3):e044905. Epub 2021 Mar 10.

Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China

Objective: To explore the association between urbanicity and hyperuricaemia (HUA) and whether urbanicity is an independent risk factor for HUA in Chinese adults.

Design: Data analysis from a cross-sectional survey.

Setting And Participants: 8579 subjects aged 18 years or older were enrolled in the study from the 2009 wave of the China Health and Nutrition Survey to analyse the association between urbanicity and HUA. We divided them into three categories according to urbanisation index (low, medium and highly urbanised groups).

Main Outcome Measures: HUA was defined as serum uric acid ≥7 mg/dL in men and ≥6 mg/dL in women.

Results: The prevalence of HUA in low, medium and highly urbanised groups was 12.2%, 14.6% and 19.8%, respectively. The independent factors influencing serum uric acid included age, gender, hypertension, diabetes, chronic kidney disease, drinking, obesity and community-level urbanisation index (β=0.016, p<0.001). The risk of HUA in the highly urbanised group was significantly higher than that of the low urbanised group (OR 1.771, 95% CI 1.545 to 2.029, p<0.001), even after adjusting for other covariates (OR 1.661, 95% CI 1.246 to 2.212, p=0.001). In a subgroup analysis, we found that age, gender, comorbidity (such as hypertension, diabetes, obesity and chronic kidney disease) and physical activity affected the association between urbanisation and the risk of HUA.

Conclusions: Our findings suggest that living in highly urbanised areas is linked with higher risk of HUA independent of cardiometabolic and health-related behavioural risk factors, which have been shown to increase along with urbanisation.
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http://dx.doi.org/10.1136/bmjopen-2020-044905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949434PMC
March 2021

Punicalin Alleviates OGD/R-Triggered Cell Injury via TGF--Mediated Oxidative Stress and Cell Cycle in Neuroblastoma Cells SH-SY5Y.

Evid Based Complement Alternat Med 2021 12;2021:6671282. Epub 2021 Feb 12.

Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

Purpose: The research aimed to identify the active component from L. to alleviate ischemia/reperfusion injury and clarify the underlying mechanism of the active component alleviating ischemia/reperfusion injury.

Materials And Methods: The SH-SY5Y cell model of oxygen-glucose deprivation/reoxygenation (OGD/R) was established to simulate the ischemia/reperfusion injury. According to the strategy of bioassay-guided isolation, the active component of punicalin from L. was identified. Flow cytometry and Western blotting were employed to evaluate the effects of OGD/R and/or punicalin on cell cycle arrest. Immunofluorescence assay was applied to assess the nucleus translocation. The relative content of ROS and GSH and the enzyme activities of CAT and SOD were examined using ELISA.

Results: The data of bioassay-guided isolation showed that punicalin from L. could alleviate OGD/R-induced cell injury in SH-SY5Y cells. Flow cytometry analysis and Western blotting for probing the expression of CDK1, p-CDK1, cyclin B1, and p21 revealed that punicalin could relieve OGD/R-induced cell cycle G0/G1 arrest. Additionally, immunofluorescence assay and Western blotting for probing the expression of TGF- and p-Smad2/p-Smad3 showed that punicalin could relieve the OGD/R-induced TGF-/Smad pathway. Furthermore, the TGF-/Smad pathway inhibitor of LY2157299 was employed to confirm that the TGF-/Smad pathway is crucial to the effect of punicalin. At last, it was indicated that punicalin could relieve OGD/R-induced oxidative stress.

Conclusion: Punicalin, an active component from L., was identified as a protective agent to alleviate the OGD/R-induced cell injury, which could exert the protective effect via TGF-/Smad pathway-regulated oxidative stress and cell cycle arrest in SH-SY5Y cells.
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http://dx.doi.org/10.1155/2021/6671282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895578PMC
February 2021

Effects of bradykinin on proliferation, apoptosis, and cycle of glomerular mesangial cells via the TGF-β1/Smad signaling pathway.

Turk J Biol 2021 9;45(1):17-25. Epub 2021 Feb 9.

Department of Nephropathy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province China.

We aimed to assess the effects of bradykinin (BK) on the proliferation, apoptosis, and cycle of glomerular mesangial cells via the transforming growth factor-β 1 (TGF-β1)/Smad signaling pathway. Rat glomerular mesangial cells, HBZY-1, were divided into normal group (untreated), model group (5 ng/L TGF-β1), BK group (5 ng/L TGF-β1 + 1 ng/L BK), and inhibitor group [5 ng/L TGF-β1 + 1 ng/L LY2109761 (TGF-β1-specific inhibitor)]. The cell proliferation, cycle, apoptosis, expression of type I collagen (Col-1), and protein expressions of Col-1, TGF-β1, and phosphorylated Smad2 (p-Smad2) were detected by EdU labeling, flow cytometry, acridine orange/ethidium bromide (AO/EB) dual staining, immunofluorescence assay, and Western blotting, respectively. Compared with the normal group, the cell proliferation rate (P = 0.02) and protein expression levels of Col-1 (P = 0.02), TGF-β1 (P = 0.01), p-Smad2 (P = 0.02), and p-Smad7 (P = 0.00) in the model group significantly increased, and apoptosis rate (P = 0.01) significantly decreased. Compared with the model group, the BK and inhibitor groups significantly decreased in proliferation rate (P = 0.01) and protein expression levels of Col-1 (P = 0.01), TGF-β1 (P = 0.01), and p-Smad2 (P = 0.00). Also, they were significantly elevated in apoptosis rate (P = 0.02) and p-Smad7 protein expression (P = 0.02). BK regulates the proliferation, apoptosis, and the cycle of glomerular mesangial cells by inhibiting the TGF-β1/Smad signaling pathway.
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http://dx.doi.org/10.3906/biy-2007-58DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877713PMC
February 2021

Identification of tumor-associated antigens of lung cancer: SEREX combined with bioinformatics analysis.

J Immunol Methods 2021 May 12;492:112991. Epub 2021 Feb 12.

School of Basic Medical Sciences & Henan Institute of Medical and Pharmaceutical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450052, Henan, China; BGI, Zhengzhou University, Zhengzhou 450052, Henan, China; Henan Key Laboratory of Tumor Epidemiology & State Key Laboratory of Esophageal Cancer Prevention, Zhengzhou University, Zhengzhou 450052, Henan, China. Electronic address:

The aim of this study is to identify novel tumor-associated antigens (TAAs) of lung cancer by using serological analysis of recombinant cDNA expression library (SEREX) and bioinformatics analysis as well as to explore their humoral immune response. SEREX and pathway enrichment analysis were used to immunoscreen TAAs of lung cancer and elaborate their function in biological pathways, respectively. Subsequently, the sera level of autoantibodies against the selected TAAs (TOP2A, TRIM37, HSP90AB1, EEF1G and TPP1) was detected by immunoserological analysis to explore the immune response of these antigens. The Gene Expression Profiling Interactive Analysis (GEPIA) and Human Protein Atlas (HPA) database were applied to explore the mRNA and protein expression level of TOP2A, TRIM37 and HSP90AB1 in tissues, respectively. Seventy positive clones were identified by SEREX which contain 63 different genes, and 35 genes of them have been reported. These 35 genes were mainly related to regulation of different transcription factor and performed enrichment in legionellosis, RNA transport, IL-17 signaling pathway via enrichment analysis. Additionally, the positive rate of autoantibodies against TOP2A, TRIM37 and HSP90AB1 in lung cancer patients were typically higher than normal control (NC; P < 0.05). Moreover, the combination of the autoantibodies against TOP2A, TRIM37 and HSP90AB1 possessed an excellent diagnostic performance with sensitivity of 84% and specificity of 60%. The mRNA expression level of TOP2A was obviously unregulated in squamous cell carcinoma (SCC) tissues and adenocarcinoma (ADC) tissues compared to normal tissues (P < 0.05). In addition, TRIM37 and HSP90AB1 also showed a significant difference between SCC and NC at the mRNA expression level (P < 0.05). This study combining comprehensive autoantibody and gene expression assays has added to the growing list of lung cancer antigens, which may aid the development of diagnostic and immunotherapeutic targets for lung cancer patients.
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http://dx.doi.org/10.1016/j.jim.2021.112991DOI Listing
May 2021

Seasonal Prevalence of Ammonia-Oxidizing Archaea in a Full-Scale Municipal Wastewater Treatment Plant Treating Saline Wastewater Revealed by a 6-Year Time-Series Analysis.

Environ Sci Technol 2021 02 4;55(4):2662-2673. Epub 2021 Feb 4.

Environmental Microbiome Engineering and Biotechnology Laboratory, The University of Hong Kong, Hong Kong SAR, China.

Although several molecular-based studies have demonstrated the involvement of ammonia-oxidizing archaea (AOA) in ammonia oxidation in wastewater treatment plants (WWTPs), factors affecting the persistence and growth of AOA in these engineered systems have not been resolved. Here, we show a seasonal prevalence of AOA in a full-scale WWTP (Shatin, Hong Kong SAR) over a 6-year period of observation, even outnumbering ammonia-oxidizing bacteria in the seasonal peaks in 3 years, which may be due to the high bioavailable copper concentrations. Comparative analysis of three metagenome-assembled genomes of group I.1a AOA obtained from the activated sludge and 16S rRNA gene sequences recovered from marine sediments suggested that the seawater used for toilet flushing was the primary source of the WWTP AOA. A rare AOA population in the estuarine source water became transiently abundant in the WWTP with a metagenome-based relative abundance of up to 1.3% over three seasons of observation. Correlation-based network analysis revealed a robust co-occurrence relationship between these AOA and organisms potentially active in nitrite oxidation. Moreover, a strong correlation between the dominant AOA and an abundant proteobacterial organism suggested that capacity for extracellular polymeric substance production by the proteobacterium could provide a niche for AOA within bioaggregates. Together, the study highlights the importance of long-term observation in identifying biotic and abiotic factors governing population dynamics in open systems such as full-scale WWTPs.
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http://dx.doi.org/10.1021/acs.est.0c07703DOI Listing
February 2021

Highly Selectivity Molecularly Imprinted Fluorescence Sensor Based on Carbon Quantum Dots for the Determination of Anthraquinones.

J Nanosci Nanotechnol 2021 04;21(4):2109-2116

Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou 412007, Hunan, China.

Due to the complexity of traditional Chinese medicines (TCMs), it is very important to develop a method that can recognize anthraquinones, the active ingredients in TCMs, with high selectivity. Here, a molecularly imprinted fluorescence sensor was coated on the surface of carbon quantum dots (CDs). Allobarbital was used as functional monomer for this application using theoretical calculations and was successfully synthesized and characterized. The template molecule chrysophanol was combined with the functional monomer allobarbital using a hydrogen bond array. Then, a series of adsorption experiments were performed to study the specific recognition of anthraquinones by the prepared sensors. The results showed that the prepared sensor had a good linear response to concentrations of chrysophanol in the concentration range 0.5 mg · L to 8.0 mg · L, a low detection limit (5.0 g · L), high stability, and a short response time (20 min). Additionally, the obtained fluorescence sensor was successfully applied to selectively recognize anthraquinones in TCMs with recoveries of 90.1% to 101.7%. The prepared sensor displays excellent sensitivity and high selectivity towards anthraquinones, mainly due to the specific hydrogen binding sites for the target molecules. Overall, this fluorescence sensor can selectively recognize anthraquinones in TCMs, and provide a method for quality monitoring and rational utilization of TCMs.
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http://dx.doi.org/10.1166/jnn.2021.19033DOI Listing
April 2021

Humoral immune response to epidermal growth factor receptor in lung cancer.

Immunol Res 2021 Feb 25;69(1):71-80. Epub 2021 Jan 25.

Henan Institute of Medical and Pharmaceutical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, 450052, Henan, China.

The aim of this study was to explore the potential value of autoantibody to epidermal growth factor receptor (EGFR) in the diagnosis of lung cancer (LC) and its relation with EGFR mutations. Enzyme-linked immunosorbent assay (ELISA) was performed to detect the level of autoantibody to EGFR in sera from 254 LC patients and 222 normal controls (NCs). Besides, the mRNA and protein levels of EGFR were investigated in Gene Expression Profiling Interactive Analysis (GEPIA) and Human Protein Atlas (HPA) database, respectively. The level of autoantibody to EGFR (anti-EGFR) in LC even different types of LC was obviously higher than that in NC (P < 0.05). The area under the curve (AUC) of anti-EGFR was 0.695 (95% CI 0.645-0.742) when comparing LC patients with NC, while the AUC of carcinoembryonic antigen (CEA) was 0.681 (95% CI 0.629-0.730). Moreover, by integrating anti-EGFR with CEA to diagnose LC, the AUC was up to 0.784 (95% CI 0.737-0.826). However, the expression level of autoantibody to EGFR had no difference between LC patients with and without EGFR gene mutation (P > 0.05). EGFR mRNA expression level was obviously upregulated in squamous cell carcinoma (SCC) tissues compared with normal tissues (P < 0.05), but not in adenocarcinoma (ADC) (P > 0.05). The study confirmed that anti-EGFR could be a potential biomarker for LC diagnosis; additionally, it could improve the diagnostic value of CEA in clinical work.
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http://dx.doi.org/10.1007/s12026-021-09174-8DOI Listing
February 2021

Regularizing Deep Networks with Semantic Data Augmentation.

IEEE Trans Pattern Anal Mach Intell 2021 Jan 21;PP. Epub 2021 Jan 21.

Data augmentation is widely known as a simple yet surprisingly effective technique for regularizing deep networks. In this paper, we propose a novel semantic data augmentation algorithm to complement traditional schemes, such as flipping, translation and rotation. The proposed method is inspired by the intriguing property that deep networks are effective in learning linearized features, such that certain directions in the deep feature space correspond to meaningful semantic transformations. Consequently, translating training samples along many such directions in the feature space can effectively augment the dataset in a semantic manner. The proposed implicit semantic data augmentation (ISDA) first obtains semantically meaningful translations using an efficient sampling based method. Then, an upper bound of the expected cross-entropy (CE) loss on the augmented training set is derived, leading to a novel robust loss function. In addition, we show that ISDA can be applied to semi-supervised learning under the consistency regularization framework, where ISDA minimizes the upper bound of the expected KL-divergence between the predictions of augmented samples and original samples. Although being simple, ISDA consistently improves the generalization performance of popular deep models (ResNets and DenseNets) on a variety of datasets, e.g., CIFAR-10, CIFAR-100, ImageNet and Cityscapes.
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http://dx.doi.org/10.1109/TPAMI.2021.3052951DOI Listing
January 2021

Identification of the raw and processed Crataegi Fructus based on the electronic nose coupled with chemometric methods.

Sci Rep 2021 Jan 20;11(1):1849. Epub 2021 Jan 20.

State Key Lab of Pharmaceutical Biotechnology, College of Life Sciences, Nanjing University, Nanjing, China.

Crataegi Fructus (CF) is widely used as a medicinal and edible material around the world. Currently, different types of processed CF products are commonly found in the market. Quality evaluation of them mainly relies on chemical content determination, which is time and money consuming. To rapidly and nondestructively discriminate different types of processed CF products, an electronic nose coupled with chemometrics was developed. The odour detection method of CF was first established by single-factor investigation. Then, the sensor array was optimised by a stepwise discriminant analysis (SDA) and analysis of variance (ANOVA). Based on the best-optimised sensor array, the digital and mode standard were established, realizing the odour quality control of samples. Meanwhile, mathematical prediction models including the discriminant formula and back-propagation neural network (BPNN) model exhibited good evaluation with a high accuracy rate. These results suggest that the developed electronic nose system could be an alternative way for evaluating the odour of different types of processed CF products.
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http://dx.doi.org/10.1038/s41598-020-79717-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817683PMC
January 2021

Characteristics and Surgical Results of Patients with Hypertrophic Obstructive Cardiomyopathy without Intrinsic Mitral Valve Diseases Undergoing Mitral Subvalvular Procedures during Myectomy.

Cardiol Res Pract 2020 9;2020:8875405. Epub 2020 Dec 9.

Shanghai Institute of Cardiovascular Diseases, 1609 Xietu Road, Shanghai 200032, China.

Background: Mitral subvalvular procedures have acquired a major role during hypertrophic obstructive cardiomyopathy (HOCM) surgery. However, few studies have focused on characterizing the clinical feature of HOCM patients without intrinsic mitral valve (MV) diseases undergoing mitral subvalvular procedures in addition to myectomy. Additionally, scant data about the results of mitral subvalvular procedures during HOCM surgery are available. This single-center study aims to characterize the clinical feature and surgical results of HOCM patients without intrinsic MV diseases undergoing mitral subvalvular procedures in addition to myectomy in comparison with those receiving myectomy alone.

Methods: Among 181 eligible patients, 50 (27.6%) patients undergoing myectomy plus mitral subvalvular procedures were entered into the combined group, and the remaining 131 patients receiving myectomy alone were included in the alone group. Baseline and surgical characteristics were investigated, and surgical results were compared.

Results: Comparatively, the combined group was younger (52.9 ± 11.2 years vs. 56.8 ± 11.8 years, =0.045) and had a better New York Heart Association (NYHA) class (=0.034) and less septal hypertrophy (16.4 ± 2.3 mm vs. 18.5 ± 3.2 mm, < 0.001). Septal thickness was independently associated with combined procedures in multivariable logistic regression analysis (OR = 0.887, 95% CI 0.612-0.917). No surgical death or iatrogenic septal perforation occurred in the combined group. Two (6.5%) patients in the combined group developed complete atrioventricular block and required permanent pacemaker implantation. During a median follow-up of 10 months, no deaths or reoperations were observed with the symptom of relief and NYHA class I or II in either group. Patients in the combined group as compared to the alone group had lower outflow tract gradients and a lower incidence of residual systolic anterior motion (SAM) syndrome.

Conclusions: For HOCM patients without intrinsic MV diseases who are scheduled for surgery, a less pronounced septal hypertrophy may be closely associated with myectomy with concomitant mitral subvalvular procedures instead of myectomy alone. Mitral subvalvular procedures during myectomy are safe and allow the reduction of outflow tract gradients and freedom from SAM more effectively in comparison with myectomy alone.
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http://dx.doi.org/10.1155/2020/8875405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744219PMC
December 2020