Publications by authors named "Yuksel Terzi"

27 Publications

  • Page 1 of 1

The relationship of illness perceptions with demographic features, pain severity, functional capacity, disability, depression, and quality of life in patients with chronic low back pain.

Turk J Phys Med Rehabil 2019 Jun 22;65(4):301-308. Epub 2019 Nov 22.

Department of Physical Medicine and Rehabilitation, Ondokuz Mayıs University Medical Faculty, Samsun, Turkey.

Objectives: The aim of this study was to evaluate the relationship of illness perceptions (IPs) with demographic features, severity of pain, functional capacity, disability, depression, and quality of life in patients with chronic low back pain (CLBP).

Patients And Methods: Between January 2015 and July 2015, a total of 114 patients with non-specific CLBP (86 females, 28 males; mean age 47.1±15.2 years; range, 18 to 85 years) were included. Non-specific CLBP was defined as low back pain not attributable to a recognizable, known specific pathology such as infection, tumor, inflammation for ≥12 weeks. The IPs using the revised Illness Perception Questionnaire (IPQ-R), pain severity using the visual analog scale (VAS), functional capacity using the Six-Minute Walk Test (6MWT), disability using the modified Oswestry Disability Index (m-ODI), depression using the Beck Depression Inventory (BDI), and quality of life using the Short Form-36 (SF-36) were assessed.

Results: There was a significant, positive correlation between the age, body mass index, duration of disease, pain scores, and IPQ-R- consequences, timeline (acute/chronic), and emotional responses subunits, whereas there was a significant, negative correlation between the IPQ-R-personal and treatment control subunits (p<0.001). The IPQ-R-timeline (acute/chronic), consequences, and emotional response subunits were positively and personal and treatment controls and illness coherence subunits were negatively correlated with the BDI and m-ODI (p<0.001). The IPQ-R-consequences and emotional responses subunits were negatively and timeline (acute/chronic), personal and treatment controls, and illness coherence subunits were positively correlated with the SF-36 subunits (p<0.05).

Conclusion: The IPs were negatively affected by advanced age, high body mass index, longer duration of disease, and increased severity of pain in CLBP patients. Based on these findings, positive IPs may be related with reduced disability and depression, and improved quality of life and functional capacity in this patient population. Developing new strategies for improving the negative IPs of patients with CLBP may be useful.
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http://dx.doi.org/10.5606/tftrd.2019.3248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935732PMC
June 2019

Reliability and Validity of Turkish Version of Short Form of the Social Role Participation Questionnaire in Patients With Ankylosing Spondylitis.

Arch Rheumatol 2018 Dec 11;33(4):408-417. Epub 2018 Apr 11.

Department of Physical Therapy and Rehabilitation, Medicine Faculty of Ondokuz Mayıs University, Samsun, Turkey.

Objectives: This study aims to evaluate the reliability and validity of the Turkish version of the Short Form of the Social Role Participation Questionnaire (s-SRPQ) in Turkish patients with ankylosing spondylitis.

Patients And Methods: The Turkish version of s-SRPQ questionnaire was obtained after a translation and back translation process. The study sample included 100 ankylosing spondylitis patients (59 males, 41 females; mean age 42.0±11.0 years; range 19 to 69 years). To assess the test-retest reliability of the Turkish s-SRPQ, the questionnaire was reapplied 15 days after the first interview (interclass correlation coefficient [ICC]). Cronbach's alpha (a) was used to evaluate the internal consistency. The s-SRPQ was compared with Short Form-36 (SF-36) survey, Ankylosing Spondylitis Quality of Life questionnaire (ASQoL), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), and Satisfaction With Life Scale (SWLS) for convergent validiy.

Results: For s-SRPQ/experienced physical difficulties; the individual item ICC ranged from 0.78 to 1.00 and Cronbach's alpha value ranged from 0.88 to 1.00. For s-SRPQ/satisfaction with role performance; the individual item ICC ranged from 0.93 to 0.98 and Cronbach's alpha value ranged from 0.96 to 0.99. The Turkish version of s-SRPQ/experienced physical difficulties scores correlated with the SWLS and SF-36 sub-parameters negatively; and Ankylosing Spondylitis Disease Activity Index, and BASFI, and ASQoL positively. The SRPQ/satisfaction with role performance scores correlated with the SWLS and SF-36 sub-parameters positively; and BASDAI, and BASFI, and ASQoL negatively.

Conclusion: Turkish version of s-SRPQ has good comprehensibility, internal consistency, and validity and is an adequate and useful instrument for the assessment of participation in Turkish patients with ankylosing spondylitis.
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http://dx.doi.org/10.5606/ArchRheumatol.2018.6756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386251PMC
December 2018

The Role of Real-Time Sonoelastography in the Differentiation of Benign From Malignant Parotid Gland Tumors.

Ultrasound Q 2018 Jun;34(2):52-57

Department of Statistics, Faculty of Art and Science, Ondokuz Mayis University, Samsun, Turkey.

Objective: The aims of this study are to evaluate the utility of sonoelastography for parotid gland masses and to determine which cutoff strain ratio (SR) would be best for the differentiation between benign and malignant lesions.

Methods: From August 2015 to December 2016, 39 parotid gland masses were examined prospectively by ultrasonography and strain sonoelastography. Elastographic scores were determined by a 4-point scoring method. Interventional procedures were performed on all patients after sonographic examinations. The lesions were divided into groups as benign or malignant according to histopathological findings. The difference in elastographic scores between benign and malignant masses was evaluated.

Results: Among the 39 parotid gland masses, 33 (84.6%) were benign and 6 (15.3%) were malignant tumors with 53.8% (n = 21) of the lesions being on the right side. Pleomorphic adenoma (41%) was the most common neoplasm followed by Warthin tumor (28.2%). The median elastographic score was 2 (range, 1-3) for benign tumors, and it was 3 (range, 2-4) (P = 0.003) for malignant tumors. Median SR was 1.11 (range, 0.26-2.15), and it was 2.75 (range, 1.03-3.54) (P = 0.01) for benign and malignant tumors. In the receiver operating characteristic analysis, the cutoff value of the SR was 2.1, sensitivity was 83.3%, specificity was 97%, positive predictive value was 83.3%, negative predictive value was 97%, and accuracy was 94%.

Conclusions: There was a statistically significant difference between benign lesions and malignant lesions in both elastography score and SR. It is possible that elastography can improve the noninvasive diagnostic accuracy for certain pathological conditions.
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http://dx.doi.org/10.1097/RUQ.0000000000000323DOI Listing
June 2018

The neurotoxic effects of prenatal gabapentin and oxcarbazepine exposure on newborn rats.

J Matern Fetal Neonatal Med 2019 Feb 5;32(3):461-471. Epub 2017 Oct 5.

e Department of Statistic, Faculty of Fine and Art , Ondokuz Mayıs University , Samsun , Turkey.

Aim: Teratogenicity is a problematic issue for pregnant women because of X-ray radiation, drugs, and genetic and unknown variables. First-generation antiepileptic drugs (AED) like valproic acid are well-known teratogens for developing fetuses. However, their usage is necessary in order to prevent maternal seizures. The underlying mechanism of birth defects associated with AED exposure remains unclear and information about the neurotoxic effects of prenatal exposure to AED is still limited. Oxcarbazepine (OXC) and gabapentin (GBP) are second-generation AED. It still remains unclear how much these drugs are safe during pregnancy. This study aimed to investigate whether any neurotoxic effect of OXC and GBP in utero exposure on the developing brain.

Methods: Eighteen pregnant Wistar albino rats were divided into six groups. The first group was exposed to OXC at 100 mg/kg/day, the second to GBP at 50 mg/kg/day, and third to saline (0.9% NaCl) at 1.5 ml/day between the first and the fifth days of gestation. The same procedure was applied at the same dosages between the 6th and the 15th days of gestation for the 2nd three groups. Five female offspring (total n = 30, 45 days old) were taken from each group and stereological methods were applied in order to analyze the total and dopaminergic neuron number of the substantia nigra pars compacta (SNc).

Conclusion: The result is that the OXC and GBP exposure at different gestational periods may not give rise to congenital malformation and it appears that the GBP exposure during the organogenesis period proliferatively affects the total number of neurons.
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http://dx.doi.org/10.1080/14767058.2017.1383378DOI Listing
February 2019

Radiological, clinical and audiological evaluation of jugular bulb-vestibular aqueduct dehiscence.

Acta Otolaryngol 2017 Dec 11;137(12):1221-1225. Epub 2017 Aug 11.

c Department of Statistics , Faculty of Art and Science, Ondokuz Mayis University , Samsun , Turkey.

Objective: The aim of this study is to determine the prevalence of jugular bulb-vestibular aqueduct dehiscence (JBVAD) in patients undergoing temporal bone multidetector computed tomography (MDCT) and assess the relationship between JBVAD and hearing loss with the findings of audiometry.

Methods: About 1503 temporal bone MDCT scans were evaluated for the prevalence of JBVAD. Correlation of the imaging findings and audiometric data was performed. Patients were divided into two groups, those with and those without hearing loss, and were statistically compared.

Results: Jugular bulb-vestibular aqueduct dehiscence was detected in 124 of the 1503 patients with a prevalence of 8.2%. MDCT images of 56 of the 124 patients were normal except for JBVAD (n = 38) and close proximity of the jugular bulb (JB) and vestibular aqueduct (VA) (n = 18). A total of 23 of 38 patients with JBVAD and 7 of 18 patients with close proximity of the JB and VA had hearing loss detected by audiometric evaluation.

Conclusions: The most common hearing loss was detected as sensorineural hearing loss in patients with JBVAD. Also, median air and bone conduction and air bone gap values were found statistically higher in patients with hearing loss versus those without hearing loss.
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http://dx.doi.org/10.1080/00016489.2017.1360516DOI Listing
December 2017

Evaluation of the Posterior Tibial Slope in Noncontact ACL Injuries Using Magnetic Resonance Imaging.

Acta Orthop Belg 2017 Jun;83(2):245-250

This study investigated whether an increased posterior tibial slope (PTS) was a risk factor for noncontact anterior cruciate ligament (ACL) injuries. We retrospectively evaluated the Magnetic Resonance (MR) images of 60 patients with noncontact complete ruptures of the ACL and 60 age-matched, healthy individuals with normal knee MR images. We measured the medial and lateral PTS on the sagittal T1W images separately in both the patients with complete ACL ruptures and the control group, as described by Hudek et al. Medial and lateral PTS were investigated between two groups .The patients with complete ACL ruptures had a statistically significantly (p<0.01) larger PTS on the lateral tibial condyle than the control group (4.5° and 3.8°, respectively). However, there was no statistically significant differences between the two groups' medial PTS. Also, the lateral PTS was greater in the complete ACL group than the control group in both females and males (p<0.01).
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June 2017

Are Illness Perceptions Associated With Disease Activity or Psychological Well-Being in Rheumatoid Arthritis? A Study With the Evidence of Confirmatory Factor Analysis.

Arch Rheumatol 2017 Dec 4;32(4):315-324. Epub 2017 Apr 4.

Department of Physical Medicine and Rehabilitation, Medical Faculty of Ondokuz Mayıs University, Samsun, Turkey.

Objectives: This study aims to assess the factor structure of the Turkish Revised Illness Perception Questionnaire (IPQ-R) in patients with rheumatoid arthritis (RA) and the relationship of illness perceptions with disease activity and psychological well-being.

Patients And Methods: One hundred and fifty RA patients (8 males, 142 females; mean age 51.1±12.7 years; range 21 to 81 years) were included in the study. Confirmatory factor analysis was used to test the factor structure of the IPQ-R. Pain was assessed by visual analog scale, disease activity by Disease Activity Score 28, depression by Beck Depression Inventory, global life satisfaction by the Satisfaction with Life Scale, and illness perception by the IPQ-R.

Results: Three items (items 12, 18, 19) were deleted because of poor factor loadings. The modified 35-item model showed good reliability and discriminant validity. Beck Depression Inventory scores were correlated with identity, consequences, and emotional representations subscales positively (p<0.001); and with illness coherence subscale negatively (p<0.05). There were positive correlations between Satisfaction with Life Scale scores, and treatment control and illness coherence subscales (p<0.05). Satisfaction with Life Scale scores were negatively correlated with identity, emotional representation, and timeline acute/chronic subscales (p<0.05), and consequences subscale (p<0.001). Disease Activity Score 28 was not correlated with IPQ-R domains (p>0.05).

Conclusion: The Turkish IPQ-R appears to be a useful clinical assessment tool to evaluate RA-related illness perceptions. RA healthcare should include psychological intervention to strengthen patients' beliefs about their RA regardless of disease activity.
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http://dx.doi.org/10.5606/ArchRheumatol.2017.6234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868392PMC
December 2017

Reliability and Validity of the Turkish Adaptation of VITACORA-19 in Patients with Psoriatic Arthritis.

Arch Rheumatol 2016 Dec 27;31(4):321-328. Epub 2016 Jul 27.

Department of Physical Medicine and Rehabilitation, Medical Faculty of Ondokuz Mayıs University, Samsun, Turkey.

Objectives: This study aims to evaluate the reliability and validity of the Turkish language version of VITACORA-19 (psoriatic arthritis quality of life questionnaire) in patients with psoriatic arthritis.

Patients And Methods: The Turkish version of VITACORA-19 questionnaire was obtained after a translation and back translation process. The study sample included 61 PsA patients (22 males, 39 females; mean age 46.5±12.2 years; range 19 to 71 years). To assess the test-retest reliability of the Turkish VITACORA-19, the questionnaire was reapplied 10 to 15 days after the first interview (interclass correlation coefficient). Cronbach's alpha (a) was used to evaluate the internal consistency. VITACORA-19 was compared with visual analog scale for physician and patient global assessments, the Health Assessment Questionnaire, and Nottingham Health Profile for construct validity. The internal structure of VITACORA-19 was examined by factor analysis.

Results: The individual item intraclass correlation coefficient ranged from 0.77 to 0.98 and Cronbach's alpha ranged from 0.77 to 0.98. The Cronbach's alpha value for whole scale was determined as 0.96. The Kaiser-Meyer-Olkin measure of sampling adequacy was 0.90, and Bartlett's test of sphericity had a p<0.001. Turkish VITACORA-19 total scores were correlated negatively with Health Assessment Questionnaire, visual analog scale for pain, and Nottingham Health Profile subgroups, and positively with physician and patient global assessments (p<0.01).

Conclusion: Turkish version of VITACORA-19 questionnaire is a reliable and valid measure for health-related quality of life in Turkish patients with psoriatic arthritis.
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http://dx.doi.org/10.5606/ArchRheumatol.2016.5741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900425PMC
December 2016

Plasma-soluble urokinase plasminogen activator receptor (suPAR) levels in Behçet's disease and correlation with disease activity.

Int J Rheum Dis 2018 Apr 12;21(4):866-870. Epub 2016 May 12.

Department of Biostatistics, 19 May University, Samsun, Turkey.

Background: Soluble urokinase plasminogen activator receptor (suPAR), a new biomarker, is a soluble form of membrane-bound receptors secreted from different immune cells. The aim of the present study is to determine plasma suPAR levels in Behçet's disease and their correlation with disease activity.

Methods: Thirty Behçet's disease patients determined according to the International Study Group criteria for Behçet's disease diagnosis and 41 healthy subjects were included in the present study. Micro-enzyme-linked immunosorbent assay was employed to obtain quantitative data. Data of both groups were statistically analyzed.

Results: The comparison of C-reactive protein and suPAR plasma levels of the control and Behçet's disease group revealed statistically significant differences (respectively, P = 0.003 < 0.05 and P = 0.020 < 0.05). However, plasma suPAR levels related with disease activity revealed no statistically significant differences (P > 0.05).

Conclusion: The present study is the first study analyzing suPAR levels in Behçet's disease patients and their correlation with disease activity. However, further prospective studies with larger patient series using suPAR as a new plasma biomarker are required to diagnose and monitor Behcet's disease and to support the findings of the present study.
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http://dx.doi.org/10.1111/1756-185X.12873DOI Listing
April 2018

Plasma-soluble urokinase plasminogen activator receptor (suPAR) levels in psoriasis patients and correlation with disease severity.

Acta Dermatovenerol Alp Pannonica Adriat 2015 ;24(4):73-5

Department of Biochemistry, Faculty of Medicine, Selçuk University, Konya, Turkey.

Objective: Psoriasis is a chronic, relapsing, inflammatory, hyper-proliferative skin disease. Plasma-soluble urokinase plasminogen activator receptor (suPAR) is released from the cell membrane-bound plasminogen activator and is a new biomarker of systemic inflammation. The aim of this study is to investigate plasma levels in psoriasis patients and determine their correlation with the Psoriasis Area and Severity Index (PASI) score.

Materials And Methods: The plasma suPAR levels of 50 healthy individuals and 65 psoriasis patients were measured using the Micro-ELISA method and the relation with PASI was investigated.

Results: On comparing plasma suPAR levels of the psoriasis patients with the control group consisting of healthy individuals, no statistically significant difference was determined (5.29 ng/ml ± 2.12 and 6.03 ng/ml ± 2.42, respectively, p = 0.326; Table 1). Likewise, there was no significant correlation between the suPAR levels and PASI score (r = 0.147, p = 0.243 > 0.05).

Conclusion: There was no statistically significant difference in the plasma SuPAR levels of psoriasis patients compared to the control group. Nevertheless, we firmly believe that plasma SuPAR, a new biomarker, could indicate disease severity if conducted with larger patient series and with moderate to severe psoriasis patients.
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http://dx.doi.org/10.15570/actaapa.2015.19DOI Listing
August 2016

The role of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in exacerbation of chronic obstructive pulmonary disease.

J Pak Med Assoc 2015 Dec;65(12):1283-7

Department of Biostatistics, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.

Objective: To investigate whether neutrophil-lymphocyte ratio and platelet-lymphocyte ratio like C-reactive protein can be used as markers of acute exacerbation in chronic obstructive pulmonary disease.

Methods: The cross-sectional study was conducted at Konya Training and Research Hospital, Konya, Turkey, between December 2012 and April 2013, and comprised patients with stable and acute chronic obstructive pulmonary disease. All participants were male and aged >40 years. Patients were included prospectively from outpatient and emergency units according to recent Initiative for Chronic Obstructive Lung Disease 2013 criteria. C-reactive protein, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio of each group were measured and compared.

Results: Of the 94 patients, 48(51%) had stable disease with a mean age of 66.65±10.17 years (range: 49-79 years), and 46(49%) had acute exacerbation with a mean age of 62.67±9.41 years (range: 48-92 years). Mean levels of C-reactive protein, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio were 5.04±6.65, 2.75±1.11 and 137.39±65.42 for stable disease, and 57.68±58.49, 7.99±5.72 and 231.18±141.36 for those with acute exacerbation (p=0.001). Cut-off values were neutrophil-lymphocyte ratio =3.3, platelet-lymphocyte ratio =150, and C-reactive protein =5 mg/dl. Positive predictive values for C-reactive protein, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio were determined as 82% (odds ratio: 27.4); 85% (odds ratio: 32.5); and 73% (odds ratio: 6.3) . Receiver-operating characteristic curve showed a significantly more area under curve of neutrophil-lymphocyte ratio (0.88) compared to platelet-lymphocyte ratio (0.74) (p<0.05).

Conclusions: During acute exacerbations of chronic obstructive pulmonary disease, neutrophil-lymphocyte ratio may be used as an easily measurable, available and cost-effective parameter with high prognostic accuracy in clinical practice.
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December 2015

Is the Mean Platelet Volume in Patients with Acute Cholecystitis an Inflammatory Marker?

J Clin Diagn Res 2015 Jun 1;9(6):TC05-7. Epub 2015 Jun 1.

Faculty of Art and Science, Department of Statistics, Ondokuzmayis University , Samsun, Turkey .

Introduction: Acute cholecystitis is an inflammatory disease of the gallbladder. Ultrasonography (US) is the initial and the most valuable method in the diagnosis of acute cholecystitis. Also, laboratory findings are used to support the diagnosis. The aim of the present study was to evaluate the diagnostic value of mean platelet volume (MPV) and platelet (PLT) counts in patients with acute cholecystitis.

Materials And Methods: From January to August 2014, the medical records of patients were reviewed for the diagnosis of acute cholecystitis. The study included 60 age-matched patients with acute cholecystitis and 60 healthy individuals as a control group. Patients with a chronic disease were excluded from the study. Over all, patients with acute cholecystitis and patients in the control group were evaluated for their MPV, PLT count, platelet distribution width (PDW), platelet crit (PCT) and erythrocyte sedimentation rate (ESR) in a complete blood count (CBC).

Results: The MPV values were found to be significantly lower in the acute cholecystitis group when compared to the control group. The PDW and PCT were found to be significantly higher in the acute cholecystitis group when compered to the control group. When a correlation test was performed, MPV was negatively correlated with PLT and PCT counts.

Conclusion: US is the initial and the most important imaging method for diagnosing and evaluating the biliary system. Also, laboratory findings such as WBC, ESR and CRP support the diagnosis but may have some undesirable limitations. However, MPV is an acute phase reactant that does not require an additional cost because it is already worked in the CBC. Therefore, MPV can be used as a marker in diagnosing inflammatory diseases.
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http://dx.doi.org/10.7860/JCDR/2015/12028.6061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525573PMC
June 2015

(18)F-FDG PET/CT mean SUV and metabolic tumor volume for mean survival time in non-small cell lung cancer.

Clin Nucl Med 2015 Jun;40(6):459-63

From the *Department of Chest Diseases, Konya Training and Research Hospital Meram, Konya, Turkey; †Department of Nuclear Medicine, Konya Training and Research Hospital Meram, Konya,Turkey; ‡Department of Thoracic Surgery, Konya Training and Research Hospital Meram, Konya, Turkey; §Medicine Faculty, Department of Biostatistics, Ondokuz Mayıs University, Samsun, Turkey; ∥Department of Radiology, Konya Training and Research Hospital, Meram, Konya, Turkey; ¶Medicine Faculty, Department of Radiology, Koç University, Istanbul, Turkey; and **Department of Pathology, Konya Training and Research Hospital, Meram, Konya, Turkey.

Objective: The study was designed to determine the relationship between survival time of standardized uptake value (SUVmax and SUVmean) and metabolic tumor volume (MTV) in patients with non-small cell lung cancer (NSCLC), and examine the impact of demographic, clinical, and radiological data of these patients on survival.

Materials And Methods: We performed a retrospective analysis of the records of 79 patients with NSCLC who presented to our hospital between May 2010 and March 2013, received a final diagnosis, and underwent F-FDG PET/CT for staging. Clinical, radiological, and F-FDG PET/CT parameters with an impact on prognosis such as the SUVmax of the primary tumor as calculated by the volumetric region of interest in the F-FDG PET/CT scans during initial diagnosis, mean SUV of the tumor, and MTV obtained with a threshold of SUVmax greater than 2.5 were recorded and statistically analyzed. A statistical analysis was carried out based on the clinical, radiological, and PET/CT findings of the patients who were divided into 2 groups: survivors and nonsurvivors.

Results: Seventy patients (88.6%) were men, and 9 (11.4%) were women. The mean age was 63.65 ± 11.51 years in the nonsurvivor group (n = 40) versus 62.74 ± 10.60 years in the survivor group (n = 39) (Table 1). The mean survival time from diagnosis was 7.9 ± 6.52 months in the nonsurvivor group versus 14.09 ± 7.41 months in the survivor group. The mean survival time was 12.9 ± 7.9 months for those aged 60 or younger, whereas it was 9.9 ± 7.2 years for those aged 60 or older. According to the Cox regression analysis, higher MTV [relative risk (RR), 1.006; P = 0.03] and mean SUVmax (mSUV) (RR, 1.302; P = 0.03) had a significant impact on shortening of the mean survival time. However, no statistical significance was reached for SUVmax measurements (RR, 0.970; P = 0.39). Furthermore, there was a significant relationship between increased tumor size (<2 cm, 2-4 cm, and ≥4 cm) and shortened mean survival time (P = 0.03).

Conclusion: The present study showed that MTV and mSUV of FDG PET/CT scans of the tumor, but not SUVmax, had a significant impact on survival time of patients with NSCLC. Based on this result, we believe that we might have more accurate information about the survival time of our patients if we also evaluate mSUV and MTV in combination with mSUV, which is frequently used for diagnosis and monitoring of patients with NSCLC during our daily practice.
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http://dx.doi.org/10.1097/RLU.0000000000000740DOI Listing
June 2015

Reliability of stool antigen tests: investigation of the diagnostic value of a new immunochromatographic Helicobacter pylori approach in dyspeptic patients.

Asian Pac J Cancer Prev 2015 ;16(2):657-60

Department of Internal Medicine, Division of Gastroenterology, Selcuk University, Selcuklu, Turkey E-mail :

Background: A diagnosis of H. pylori infection can be made by invasive or non-invasive methods. Several noninvasive diagnostic tests based on the detection of H. pylori stool antigen (HpSA) have been developed. The Genx H. pylori stool antigen card test is a new rapid, non-invasive test that is based on monoclonal immunochromatographic assay. The aim of this study was to determine its sensitivity, specificity, and diagnostic accuracy for diagnosing H. pylori infection in adult patients.

Materials And Methods: A total of 162 patients were included in the study. A gastric biopsy was collected for histopathology and rapid urease testing. Stool specimens for HpSA testing were also collected. Patients were considered H. pylori positive if two invasive tests (histological and rapid urease tests) were positive.

Results: Using the reference test, 50.6% of the samples were positive for H. pylori infection. The Genx H. pylori antigen test was positive in 19.7% of patients. The sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of the Genx H. pylori antigen test were 51.6%, 96.0%, 88.8%, 76.1%, and 79.0%, respectively.

Conclusions: The Genx H. pylori stool antigen card test is a new non-invasive method that is fast and simple to perform but provides less reliable results.
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http://dx.doi.org/10.7314/apjcp.2015.16.2.657DOI Listing
December 2015

Assessment of evidence for positive association and seroprevalence of hepatitis B and C in diabetic patients in a developing country.

J Investig Med 2015 Feb;63(2):251-7

From the *Department of Internal Medicine, Division of Gastroenterology, Selcuk University, Faculty of Medicine; †Department of Microbiology, Konya Education and Research Hospital, Konya; ‡Department of Internal Medicine, Izmir Katip Celebi University, Faculty of Medicine, Izmir; §Department of Internal Medicine, Division of Endocrinology and Metabolism, Selcuk University, Faculty of Medicine, Konya; and ∥Department of Statistics, Ondokuz Mayis University, Faculty of Science and Arts, Samsun, Turkey.

Background And Aim: The data related to the association between hepatitis virus infections and diabetes mellitus (DM) are conflicting. The aim of this study was to investigate the seroprevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) and to determine the risk factors affecting the prevalence in Turkish patients with type 1 DM and type 2 DM.

Methods: The study consisted of 736 diabetic and 505 nondiabetic patients. Serological investigation for the hepatitis B surface antigen (HBsAg) and the HCV antibody (anti-HCV) was performed with a third-generation commercial chemiluminescence assay. The presence of HBsAg was considered as indicator of HBV infection. The HCV infection in the patients with positive anti-HCV was confirmed by a real-time polymerase chain reaction assay. The patients were divided according to their HBV and HCV infection status, and their demographic features, diabetes properties, general risk factors, and aminotransferase levels were analyzed.

Results: There was no significant difference in the seropositivity rate for the HBsAg (3.8% vs 3.0%, P > 0.43; odds ratio, 1.292; 95% confidence interval, 0.683-2.444). However, anti-HCV seropositivity was significantly increased in the DM group (3.3% vs 1.8%, P < 0.03; odds ratio, 2.398; 95% confidence interval, 1.025-5.609). Increased aminotransferase levels and a history of blood transfusions were positively correlated with both HBV and HCV infection. Moreover, a history of surgical procedures and high glycated hemoglobin A1c levels were positively associated with HBsAg antigen seropositivity.

Conclusions: Although no significant difference in the seropositivity of the HBsAg was determined, a high prevalence of HCV infection was detected in the DM patients compared to healthy controls.
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http://dx.doi.org/10.1097/JIM.0000000000000126DOI Listing
February 2015

Predicting survival for multiple myeloma patients using baseline neutrophil/lymphocyte ratio.

Ann Hematol 2014 May 14;93(5):841-6. Epub 2013 Dec 14.

Department of Hematology, Erzurum Region Training and Research Hospital, Bölge Eğitim ve Araştırma Hastanesi, 25770, Erzurum, Turkey,

The neutrophil/lymphocyte ratio (NLR) at diagnosis has been shown to be a prognostic factor for survival in solid tumors. The NLR at diagnosis as a prognostic factor for multiple myeloma (MM) has not been studied. Therefore, the focus of the study was the correlation of NLR with the proven prognostic parameters in patients with MM. A total of 151 MM patients who fulfilled the International Myeloma Working Group (IMWG) criteria were enrolled in the study by a retrospective review of the patients' records. One hundred fifty-one age- and gender-matched healthy controls were also included in the study. NLR was calculated using data obtained from the complete blood count (CBC). NLR was significantly higher in MM patients than the control group (2.79 ± 1.82 vs. 1.9 ± 0.61, respectively; p < 0.0001). The median follow-up on living patients in this study was 41 months. NLR at the diagnosis was found to be an independent predictor for overall survival (OS) and event-free survival (EFS) by univariate and multivariate analysis. Patients with a NLR <2 at diagnosis experienced superior OS compared with patients with a NLR ≥2 (5-year OS rates were 87.5 and 42.4 %, respectively; p < 0.0001). In a similar fashion, superior EFS was observed in patients with a NLR <2 at the diagnosis compared with patients with a NLR ≥2 (5-year EFS rates were 88.4 and 41.8 %, respectively, p < 0.0001). This study suggests that NLR at the diagnosis is a simple, inexpensive, possible prognostic factor to assess clinical outcomes in MM patients.
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http://dx.doi.org/10.1007/s00277-013-1978-8DOI Listing
May 2014

Investigation of the relation between anaerobic bacteria genus clostridium and late-onset autism etiology in children.

J Immunoassay Immunochem 2014 ;35(1):101-9

a Department of Microbiology , Konya Education and Research Hospital , Konya , Trukey.

The aim of this study was to investigate the relation between the etiology of late-onset childhood autism and anaerobic bacteria. Thirty children diagnosed with autistic disorder and control group have been included in the study. 3-(3-hydroxy phenyl)-3-hydroxypropionic acid (HPHPA) excretion rates which is a metabolic product of the genus Clostridium, were measured via mass spectrometry-gas chromatography (MS-GC) method from urine samples. When the assayed average HPHPA values compared with each group, a statistically significant difference was found (p < 0.05). Data obtained from this study support the existence of a significant correlation between autism etiology and anaerobic bacteria.
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http://dx.doi.org/10.1080/15321819.2013.792834DOI Listing
April 2014

Comparison of the diagnostic accuracy of five different stool antigen tests for the diagnosis of Helicobacter pylori infection.

Helicobacter 2013 Oct 3;18(5):384-91. Epub 2013 Apr 3.

Faculty of Medicine, Division of Gastroenterology, Department of Internal Medicine, Selcuk University, Konya, Turkey.

Background: Several noninvasive diagnostic tests based on the detection of Helicobacter pylori stool antigen (HpSA) have been developed. The aim of the study was to compare the diagnostic accuracy of 5 HpSA tests-2 monoclonal enzyme immunoassay tests (EIAs: the Premier Platinum HpSA Plus test and Helicobacter pylori Antigen (Hp Ag) test) and 3 rapid immunochromatographic assay (ICA) tests (the ImmunoCard STAT! HpSA test, one step HpSA test, and H. pylori fecal antigen test)--for diagnosing H. pylori infection in adult patients with dyspeptic symptoms before eradication therapy.

Materials And Methods: A total of 198 patients with dyspeptic symptoms were included in the study. A gastric biopsy was collected for histopathology and rapid urease testing. Stool specimens for HpSA testing were also collected. Patients were considered H. pylori positive if two invasive tests (histological and rapid urease tests) were positive.

Results: The sensitivity and specificity were 92.2% and 94.4%, respectively, for the Premier Platinum HpSA Plus test; 48.9% and 88.9%, respectively, for the HP Ag test; 86.7% and 88.9, respectively, for the One Step HpSA test; 68.9% and 92.6%, respectively, for the ImmunoCard STAT! HpSA test; and 78.9% and 87%, respectively, for the H. Pylori fecal antigen test.

Conclusions: The Premier Platinum HpSA Plus EIA test was determined to be the most accurate stool test for diagnosing H. pylori infections in adult dyspeptic patients. The currently available ICA-based tests are fast and easy to use but provide less reliable results.
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http://dx.doi.org/10.1111/hel.12053DOI Listing
October 2013

Comparing models of the effect of air pollutants on hospital admissions and symptoms for chronic obstructive pulmonary disease.

Cent Eur J Public Health 2012 Dec;20(4):282-6

Department of Statistics, University of Ondokuz Mayis, Samsun, Turkey.

There is an increasing interest in the use of hospital admission for Chronic obstructive pulmonary disease (COPD) in studies of short-term exposure effects attributed to air pollutants. However, little is known about the effect of air pollutants on COPD symptoms. This study was undertaken to determine whether there was an association between air pollutant levels and both hospital admissions and symptoms for COPD. For model comparison, we present Generalized Linear Model, Generalized Additive Model and a general approach for Bayesian inference via Markov chain Monte Carlo in generalized additive model. Furthermore, for comparing the predictive accuracy, Artificial Neural Networks (ANN) approach is given.
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http://dx.doi.org/10.21101/cejph.a3757DOI Listing
December 2012

Comparison of a newly developed automated and quantitative hepatitis C virus (HCV) core antigen test with the HCV RNA assay for clinical usefulness in confirming anti-HCV results.

J Clin Microbiol 2011 Dec 21;49(12):4089-93. Epub 2011 Sep 21.

Konya Education and Research Hospital, Microbiology Laboratory, Konya 42090, Turkey.

Hepatitis C virus (HCV) is a global health care problem. Diagnosis of HCV infection is mainly based on the detection of anti-HCV antibodies as a screening test with serum samples. Recombinant immunoblot assays are used as supplemental tests and for the final detection and quantification of HCV RNA in confirmatory tests. In this study, we aimed to compare the HCV core antigen test with the HCV RNA assay for confirming anti-HCV results to determine whether the HCV core antigen test may be used as an alternative confirmatory test to the HCV RNA test and to assess the diagnostic values of the total HCV core antigen test by determining the diagnostic specificity and sensitivity rates compared with the HCV RNA test. Sera from a total of 212 treatment-naive patients were analyzed for anti-HCV and HCV core antigen both with the Abbott Architect test and with the molecular HCV RNA assay consisting of a reverse transcription-PCR method as a confirmatory test. The diagnostic sensitivity, specificity, and positive and negative predictive values of the HCV core antigen assay compared to the HCV RNA test were 96.3%, 100%, 100%, and 89.7%, respectively. The levels of HCV core antigen showed a good correlation with those from the HCV RNA quantification (r = 0.907). In conclusion, the Architect HCV antigen assay is highly specific, sensitive, reliable, easy to perform, reproducible, cost-effective, and applicable as a screening, supplemental, and preconfirmatory test for anti-HCV assays used in laboratory procedures for the diagnosis of hepatitis C virus infection.
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http://dx.doi.org/10.1128/JCM.05292-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233016PMC
December 2011

Reliability and validity of the Turkish version of the Falls Efficacy Scale International (FES-I) in community-dwelling older persons.

Arch Gerontol Geriatr 2012 May-Jun;54(3):429-33. Epub 2011 Aug 9.

Department of Physical Medicine and Rehabilitation, Medical Faculty, Ondokuz Mayis University, Samsun, Turkey.

The FES-I is a questionnaire which was developed to assess fear of falling. The aim of this study was to evaluate validity and reliability of a Turkish language version of the FES-I in Turkish older people. The study sample included 70 volunteers with an age range of 65-81. To assess the test-retest reliability of the Turkish FES-I, questionnaire was applied again 10-15 days after the first interview (interclass correlation: ICC). FES-I was compared with The Modified Barthel Index (MBI), the timed up and go test (TUG), and The Berg Balance Scale (BBS) for construct validity. Cronbach's alpha (α) was used to evaluate the internal consistency. The internal structure of the FES-I was examined by factor analysis. ROC plots were used to define cut-point for the FES-I scales. Cronbach's α of the Turkish FES-I was 0.94 and the individual item ICC ranged from 0.97 to 0.99. The Turkish FES-I total scores were correlated with TUG positively, and MBI, and BBS negatively. The cut-off score to differentiate between persons with fear of falling and persons without fear of falling was 24 points. It was found that the Turkish version of the FES-I was a reliable and valid measure of fear of falling in Turkish older people.
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http://dx.doi.org/10.1016/j.archger.2011.06.010DOI Listing
August 2012

The correlation between hematoma volume and outcome in ruptured posterior fossa arteriovenous malformations indicates the importance of surgical evacuation of hematomas.

Turk Neurosurg 2011 ;21(2):152-9

M.H. Sisli Etfal Research and Education Hospital, Department of Neurosurgery, Istanbul, Turkey.

Aim: The correlation between hematoma volume and outcome in ruptured arteriovenous malformations (AVM) with accompanying posterior fossa hematoma was retrospectively evaluated.

Material And Methods: Microsurgery operations were performed on 127 patients with intracranial AVM between January 1998 and January 2009 at our clinic. Fifteen (11.8%) patients were identified as suffering from posterior fossa AVM, and twelve of these patients presented with a cerebellar hematoma. All patients were clinically evaluated according to the following criteria: modified Rankin Scale (mRS) prior to surgery, Spetzler-Martin grade (SMG) of the AVMs, hematoma volume prior to surgery, and mRS following surgery.

Results: Postoperative mRS scores were significantly lower than preoperative scores (p=0.0001). Postoperative outcomes were concordant with the SMG of the AVMs (r=0.67, p=0.033), hematoma volume (r=0.537, p=0.072) and preoperative mRS scores (r=0.764, p=0.004). These analyses show that the postoperative mRS score is strongly correlated with a preoperative mRS score, hematoma volume and SMG.

Conclusion: Posterior fossa AVMs present an increased risk for hemorrhage and for increased morbidity and mortality. Cases with hematoma should be operated on an urgent basis. We conclude that hematoma volume is a factor that impacts postoperative results and prognosis. SMG and preoperative mRS scores were also correlated with outcome.
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http://dx.doi.org/10.5137/1019-5149.JTN.3401-10.0DOI Listing
September 2011

When is duraplasty required in the surgical treatment of Chiari malformation type I based on tonsillar descending grading scale?

World Neurosurg 2011 Feb;75(2):307-13

Department of Neurosurgery, Sisli Research and Education Hospital, Istanbul, Turkey.

Objective: To evaluate the effect of duraplasty based on cerebellar tonsillar descent (CTD) grade in the surgical treatment of Chiari malformation type I (CM-I).

Methods: Medical records and magnetic resonance imaging (MRI) scans of 82 patients with surgical correction of CM-I performed at the authors' clinic from 1998-2009 were reviewed. The preoperative CTD grading scale was obtained. Patients were divided two groups: duraplasty group (group 1) and nonduraplasty group (group 2). The preoperative and postoperative size of the syringomyelia cavity, Japanese Orthopaedic Association (JOA) scores, recovery rate, and postoperative complications were determined.

Results: There was 58 patients in group 1, who underwent combined foramen magnum decompression, C1 (and C2 if necessary) laminectomy, and duraplasty; the 24 patients in group 2 underwent posterior fossa decompression (PFD) alone with no dural opening performed. There were no statistically significant differences between preoperative and postoperative size of the syringomyelia cavity and JOA scores of duraplasty (group 1) and nonduraplasty (group 2) groups in CTD grades 1 and 2; in CTD grade 3, the decrease in syrinx cavity and clinical improvement were statistically better in group 1 compared with group 2 (P < 0.05). Complications in group 1 were statistically significantly increased compared with group 2 (P < 0.05).

Conclusions: This study shows that PFD and duraplasty for the treatment of CTD grade 3 Chiari malformation may lead to a more reliable reduction in the volume of concomitant syringomyelia and JOA scores. In CTD grade 1 and 2 patients, PFD without duraplasty may be performed.
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http://dx.doi.org/10.1016/j.wneu.2010.09.005DOI Listing
February 2011

Comparison of the diagnostic values of the 3 different stool antigen tests for the noninvasive diagnosis of Helicobacter pylori infection.

J Investig Med 2010 Dec;58(8):982-6

Konya Education and Research Hospital, Microbiology Laboratory, Yeniyol, Meram, Konya, Turkey.

The aim of the study was to compare 3 stool antigen tests for diagnosis of Helicobacter pylori infection in adult patients with dyspeptic complaints before eradication therapy. We compared 2 enzyme immunoassays (EIAs: Premier Platinum Helicobacter pylori Stool Antigen [HpSA] Plus and Helicobacter pylori Antigen [Hp Ag]) and one immunochromatographic assay (H. pylori fecal antigen test-lateral-flow chromatography) in detecting H. pylori. All the investigated stool antigen tests were made of monoclonal antibodies. We evaluated 168 adult patients with H. pylori infection by using 2 criterion standard methods (histological and rapid urease tests) together. The sensitivity and specificity were 90% and 91%, respectively, for the Premier Platinum HpSA Plus, 77% and 91%, respectively, for the Hp Ag, and 81% and 92%, respectively, for the H. pylori fecal antigen test, respectively. The best agreement between the criterion standard tests and the stool antigen tests used in the study was with the Premier Platinum HpSA Plus. Immunochromatographic assay-based stool antigen test (H. pylori fecal antigen test) was found to be more sensitive than the EIA-based test (Hp Ag). One of the 2 important conclusions obtained from the study was that the Premier Platinum HpSA Plus was found to be the most accurate test for the diagnosis of H. pylori infection in adult dyspeptic patients before eradication therapy, and the other was that monoclonal and high-quality, reliable immunochromatographic assay tests are a good option especially for small hospital laboratories that do not have appropriate equipment for performing the EIA and working on few samples.
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http://dx.doi.org/10.231/JIM.0b013e3181f31569DOI Listing
December 2010

Advantages of autologous blood transfusion in off-pump coronary artery bypass.

Heart Surg Forum 2009 Oct;12(5):E261-5

Department of Anesthesiology, Kocatepe University, Afyonkarahisar, Turkey.

Background: In this randomized controlled study, we investigated the effects of autologous Hemobag blood transfusion (AHBT) and allogenic blood transfusion (ABT) in off-pump coronary artery bypass (OPCAB) surgery.

Methods: Sixty patients who underwent surgery between February 2008 and August 2008 were randomized into 2 groups. The AHBT group (n = 30) consisted of patients who received autologous Hemobag blood transfusion, and the ABT group (n = 30) consisted of patients who received allogenic blood transfusion. All patients underwent OPCAB via sternotomy. The time to extubation, chest tube drainage volume, postoperative white blood cell counts, amount of blood transfusion, sedimentation rate, C-reactive protein concentration, postoperative temperature, and the presence of atelectasis were recorded in the intensive care unit.

Results: Intraoperative bleeding and fluid resuscitation were similar in the 2 groups (P > .05); however, there were significant decreases in postoperative blood loss, extubation period, postoperative white cell counts, sedimentation rate, incidence of atelectasis, C-reactive protein, and fever in the AHBT group compared with the ABT group (P < .05). The rate of atrial fibrillation in the AHBT group tended to be lower than in the ABT group.

Conclusion: Autologous blood transfusion in OPCAB may be beneficial in certain cardiac surgery patients; however, these beneficial effects require further study to be proved.
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http://dx.doi.org/10.1532/HSF98.20081115DOI Listing
October 2009

Poster presentations.

Authors:
Funda Aksu Hakan Topacoglu Candan Arman Aytul Atac Suleyman Tetik Aida Hasanovic Amela Kulenovic Zakira Mornjakovic Branko Pikula Aida Sarac-Hadzihalilovic Alma Voljevica Belgin Bamac Tuncay Colak Murat Alemdar Gulmine Dundar Macit Selekler Ozgur Dincer Enis Colak Aydin Ozbek Cenk Kilic Kivanc Kamburoglu Tuncer Ozen Vatan Kavak Yalcin Kirici Emin Oztas Handan Altinkaya Soysal Erdogan Unur Nihat Ekinci Omur Karaca Olga Malakhova Murat Kocaoglu Serdar Toker Figen Taser Volkan Kilincoglu Mustafa Fahri Yurtgun Cannur Dalcik Ali Zeybek Marc Baroncini Johann Peltier Patrice Jissendi Jean-Pierre Pruvo Jean-Paul Francke Vincent Prevot Rengin Kosif Yasin Arifoglu Murat Diramali Mustafa Sarsilmaz Evren Kose Murat Ogeturk Burhan Akpinar Ilter Kus Sedat Meydan Alev Kara Zeliha Kurtoglu Ibrahim Tekdemir Alaittin Elhan Orhan Bas Ersan Odaci Hakan Mollaoglu Kagan Ucok Suleyman Kaplan Mehmet Senoglu Vedat Nacitarhan Ergul Belge Kurutas Nimet Senoglu Idris Altun Yalcin Atli Davut Ozbag Sacide Karakas M Dincer Bilgin Ayfer Metin Tellioglu Sercin Ozlem Betul Akcanal Yuksel Yildiz Hakki Gunes Hayrullah Kose Ibrahim Uzum Umit Naci Gundogmus Cigdem Caglayan Velichka Pavlova Mashenka Dimitrova Lilia Georgieva Elena Nikolova Deniz Uzmansel Nail Can Ozturk Canan Yurttas Saylam Erkin Ozgiray Mustafa Orhan Sedat Cagli Mehmet Zileli Derya Ozkan Taylan Akkaya Ayhan Comert Nilgun Balikci Esra Ozdemir Haluk Gumus Zafer Ergul Oskay Kaya Serdar Altun R Erkin Unlu Hakan Orbay Deog-Im Kim Seung-Ho Han Yi-Suk Kim Ho-Jeong Kim Kyu-Seok Lee Omur Elcioglu Hilmi Ozden Gul Guven Nurcan Imre Bulent Yalcin Hasan Ozan Pinar Akyer Mustafa Guvencer Vasfi Karatosun Mandeep Gill Sagoo Rachel Claire Aland Derya Ustuner M Cengiz Ustuner Jafar Ai Seyed Reza Ghazi Seyed Hadi Mansouri Mehmet Cudi Tuncer Mehmet Ufuk Aluclu Ozlen Karabulut Eyup Savas Hatipoglu Hasan Nazaroglu Cigdem Icke Emrah Akbay Turkan Gunay Suleyman Icke Selda Yildiz Fatih Yazar Barcin Orhan Barlas Delia Elena Zahoi Ahmet Kavakli Ufuk Tas Durrin Ozlem Dabak Hilal Irmak Sapmaz Necdet Kocabiyik Cenk Murat Ozer Ayhan Ozcan Levent Elevli Kadir Desdicioglu Ibrahim Alanbay Figen Govsa Canan Y Saylam Ilgaz Akdogan Yilmaz Kiroglu Sule Onur Emine Hilal Evcil Neslihan Cankara Mehmet Ali Malas M Tayyar Kalcioglu Serdar Duman Tufan Ulcay Ahmet Uzun Zulfu Karabulut Cagatay Barut Ozdemir Sevinc Gamze Yurdakan Dundar Kacar Ali Riza Erdogan Hulyam Kurt Bunyamin Demir Mustafa Saltan Dilek Burukoglu Mehmet Cengiz Ustuner Irfan Degirmenci Aliriza Erdogan Ozlem Damar Merih Is Gokhan Bayramoglu Sahin Kabay Onur Uysal Hakan Senturk Aysegul Bayramoglu Cansu Ozbayar Ali Kutlu Mediha Canbek Salih Cenap Cevli Oguz Hancerlioglu Mustafa Koplay Elif Aksakalli Fatih Dikici Aysin Kale Ozcan Gayretli Ilke Ali Gurses Senem Turan Ozdemir Ilker Ercan Emel Bulbul Baskan Mediha Yilmaz Guven Ozkaya Hayriye Saricaoglu Mete Erturk Gulgun Kayalioglu Mehmet Uzel Guler Kahraman Ercan Tanyeli Ali Ihsan Soyluoglu Orhan Tacar Ayda Demirant Murat Bilgin Aziz Karadede Ayfer Aktas E Hilal Evcil Esra Koyuncu Osman Sulak Soner Albay Gulnur Ozguner Ahmet Ozbek Elvan Ozbek A Hakan Ozturk Tuba Demirci Engin Ciftcioglu Mehmet Tevfik Demir Cem Kopuz Esra Eroglu Semin Gedikli Hamit Ozyurek Mehmet Selim Nural Lutfi Incesu Gonul Ogur Engin Kara Baris Celebi Altan Yildiz B Zuhal Altunkaynak Samet Vasfi Kuvat Suleyman Murat Tagil Cumhur Ertekin Hilmi Uysal Fikret Bademkiran Nural Albayrak Ali Firat Esmer Nigar Keles Coskun Muzaffer Sindel Ferah Kizilay Sevket Yalin Nevin Karapinar Mehmet Tokdemir Lokman Karakurt Levent Tumkaya Adnan Korkmaz Bulent Ayas Nusret Ciftci Yuksel Terzi Ozlem Baran Yusuf Nergiz Murat Akkus Ufuk Aluclu Askin Ender Topal Dilek Yuksel Halil Ibrahim Acar Simel Kendir Emre Hekimoglu Deniz Basman Sunay Duman Baris Ozener Can Pelin Ragiba Zagyapan Ayla Kurkcuoglu Mustafa Koc Meral Erdinc Levent Erdinc Ilker Kelle Enver Sancakdar Nil Cetin Selcuk Tunik Ayse Yildirim Iskender Kaplanoglu Ercan Ayaz Necip Ilhan Mehmet Okumus Kasim Zafer Yuksel Harun Ciralik Zeki Yilmaz Yakup Gumusalan Mehmet Gamsizkan Mustafa Kazkayasi Nadire Unver Dogan Ismihan Ilknur Uysal Aylin Karalezli Zeliha Fazliogullari Mustafa Buyukmumcu Mehmet Cem Bozkurt Aynur Emine Cicekcibasi Deniz Demiryurek M Hakan Ozsoy Alp Bayramoglu Eray Tuccar Ozlem Pamukcu Baran Sevda Soker Selen Bahceci Yasemin Nasir Mehmet Tugrul Yilmaz Emine Aynur Cicekcibasi Mahinur Ulusoy Pervin Gunaslan Nuray Bilge Muzaffer Akkaya Abdurrahman Genc Sezer Akcer Yucel Gonul Emine Cosar Gulengul Koken Ilknur Ari Sinan Bakirci Ilker Mustafa Kafa Murat Uysal Ahmet Kagan Karabulut Bahar Keles Dilek Emlik Yavuz Uyar Kayhan Ozturk Neslihan Altuntas Yilmaz Ahmet Salbacak Burkay Kutluhan Kacira Mehmet Arazi Serafettin Demirci Demet Kiresi Serter Gumus Muzaffer Seker Mehmet Uyar Mohammad Ebrahim Astaneh Alireza Khorshid Ramazan Uygur Ahmet Songur Osman Fikret Sonmez Kamil Hakan Dogan Giray Kolcu Madalina Iliescu Petru Bordei Dan Iliescu Camelia Ciobotaru Viorel Lucescu Anatoli Covaleov Constantin Ionescu Miguel Guirao E Páramo R Mutuberria I Sánchez-Montesinos O Roda F Girón Miguel Lopez-Soler Olga Roda Raúl Campos-López Miguel Guirao-Piñeiro Maria Teresa Pascual-Morenilla Indalecio Sanchez-Montesinos Maria Teresa Pascual I Garzon D Serrato R Nieto-Aguilar I Sanchez-Montesinos M Sanchez-Quevedo M Bulent Ozdemir R Hakan Ozean Dilek Bagdatli Esat Adiguzel Zumrut Dogan Ozlem Aycan Nigar Vardi Haldun Sukru Erkal Hakan Ozturk S Mocanu C Stefanescu A Ionescu Raluca Talpes Elena Sapte Constantin Dina Loredana Surdu Ionut Bulbuc M T Medina J Medina M López-Soler Carlos Martin-Oviedo Alejandro Lowy-Benoliel Eva Maranillo Tomas Martinez-Guirado Jose Sañudo Bartolome Scola Teresa Vazquez L A Arráez-Aybar J L Conejo-Menor C C Gonzáles-Gómez A J Torres-García Hisayo Nasu Shoji Chiba M Gutierrez-Semillera Yahya Paksoy Ahmet Kalaycioglu Mehmet Yildirim Ali Ozyasar Omer Ozdogmus Yusuf Ozgur Cakmak Ural Verimli Safiye Cavdar Begum Yildizhan Z Asli Aktan Ikiz Hulya Ucerler Zuhal Ozgur Seher Yilmaz Abdullah Demirtas Ertugrul Mavili Mehtap Hacialiogullari Hatice Susar Seda Arslan Kenan Aycan Vecihi Ozkaya Mara Pilmane Sarmite Boka Gursel Ortug Carlos Ramirez Aran Pascual-Font Francisco Valderrama-Canales Abdulah Kucukalic Eldan Kapur Elvira Talovic Vaclav Baca Robert Grill Zdenek Horak David Kachlik Valer Dzupa Marek Konarik Jakub Knize Petr Veleminsky Tereza Smrzova Michal Otcenasek Jana Chmelova Michal Kheck Michal Kheck Tomas Cupka Lukas Hnatek Floris van der Meijs Pavel Cech Vladimir Musil H Mustafa Ozkan S Kivanc Muratli Hamid Tayefi Ipek Ergur Amac Kiray Muhsin Toktas Ozan Alkoc Tolgahan Acar Ibrahim Uzun Oguz Asian Ozen Abdullah Aycicek Ozan Alper Alkoc Mehmet Unlu Ufuk Corumlu Ihsaniye Coskun Ikiz I Hakan Oygucu Erdogan Sendemir Tuncay Kaner Veli Caglar Olcay Eser Mehmet T Demir Omer Iyigun Gokhan Pirzirenli Ahmet Hilmi Kaya Mennan Ece Aydin Fahrettin Celik Hakan True Sevket Ozkaya Bekir Ugur Ergur Gulsah Zeybek Kadir Bacakoglu Mina Tadjalli Aghdas Poostpasand Seid Hadi Mansouiri Ozra Allahvaisi Jafar Soleimanirad Bahram Nikkhoo Yasukazu Nagato Yasuo Haruki Komazo Yazawa Tutomu Okazaki Munetaka Haida Yutaka Imai Thmineh Peirouvi Mehrzad Mahzad-Sadaghiani Farahnaz Noroozinia Salami Siamak Gholamhosseine Farjah Sima Mola Ewa Biegaj Tymon Skadorwa Konrad Pawlewicz Robert Kapolka Agata Chachulska Joanna Zabicka Aleksandra Krasowska Alicja Prusik Grzegorz Jaczewski Adam Kolesnik M Mohsen Taghavi S Hasan Alavi S Adel Moallem Zahed Safikhani Marzieh Panahi Shahriar Dabiri Majid Asadi Shekaari Rafael Latorre Federico Soria Octavio Lopez-Albors Ricardo Sarria Inacio Ayala Inma Serrano Enrique Perez-Cuadrado Vladimir Musienko Dmitry Tkachenko Neriman Colakoglu Murat Abdulgani Kus Mahdi Jalali Mohammad Reza Nikravesh Abbas Ali Moeen Mohammad Hassan Karimfar Houshang Rafighdoost Shabnam Mohammadi Marina Korneeva Houshang Rafighdoust Kvetuse Lovasova Adriana Bolekova Darina Kluchova Igor Sulla Marina Yurievna Kapitonova Syed Baharom Syed Ahmad Fuad Flossie Jayakaran Ali Reza Shams Fereshteh Aghaee Zohreh Baqer Mohamad Faroki Srijit Das Normadiah Kassim Azian Latiff Frihah Suhaimi Norzana Ghafar Khin Pa Pa Hlaing Israa Maatoq Faizah Othman Muge Kiray Husnu Alper Bagriyanik Cetin Pekcetin Candan Ozogul Mustafa Fidan Farihah Suhaimi Fei Sun Francisco Sanchez-Margallo Francisco Gil Verónica Crisostomo Jesus Uson Gegorio Ramirez Ozan Turamanlar Oguz Kirpiko Alpay Haktanir Salvador Climent Sergio Losilla Maria Climent Levent Sarikcioglu Yesim Senol Fatos B Yildirim Arzu Utuk Jacek Kunicki Parichehr Pasbakhsh Negar Omidi Hamed Omidi Fatemeh Dehghani Nazhvani Seyed Razi Ghalebi Nima Javan Akrami Mohagery Ali Reza Ebrahimzadeh Bideskan Mohammad Mehdi Hassanzadeh Taheri Ali Reza Fazel Cesare Tiengo Veronica Macchi Carla Stecco Andrea Porzionato Franco Mazzoleni Raffaele De Caro Alberto Clemente Aldo Morra Pietro Greco Piero Pavan Arturo Natali Mehmet Demir Mehmet Dokur Niyazi Acer Ayfer Mavi Niki Matveeva Dobrila Lazarova Kostandina Korneti Svetlana Jovevska Dragica Jurkovik Meri Papazova Masoumeh Havasi Naeim Alboghobeish Ahmad Savari Negin Salamat Mozafar Sharifi Hyun-Ho Kwak Kyung-Seok Hu Gyoo-Cheon Kim Bong-Soo Park Hee-Jin Kim Ahmet Sinav Adarsh K Gulati Nidhi K Gulati Hussien Alshammary Seifollah Dehghani Nazhvani Amir Vafafar Tahereh Esmaeilpour Soghra Bahmanpour Leila Elyasi Ahmad Monabbati M Ghanadi Mohammad Reza Paryani Hassan Gilanpour Banino Amirsam Rodrigo Elizondo Omaña Santos Guzmán López Oscar De la Garza Castro Edgar Urrutia Vega Santos Guzman Lopez Freshteh Talebpour Rahim Golmohammadi Golamreza Dashti Mohammad Ali Atlasi Mehdi Mehdizadeh Mohammad Hadi Bahadori Mohammad Taghi Joghataei Leili Hatami Mandana Beigi Boroujeni Jasem Estakhr Ebrahim Esfandiary Mohsen Marzban Mehrdad Bakhtiary Navid Modiry Mokhtar Jafarpur Hassan Mofidpur S Hassan Alavi Alareza Mahmoudian Mohmmad Mohsen Taghavi Mokhtar Jafarpour Ali Reza Mahmoudian Nasrin Sanjarmousavi Ines Doassans Natalia Sorrenti German Decuadro Andres 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Mohammad Taghi Joghataie Mehrdad Roghani Salin Murat Akkin Gulten Dinc Mustafa Kurklu Sener Ozboluk Mahmut Komurcu Jürgen Koebke Mehmet Bulent Balioglu Mehmet Akif Kaygusuz Ferdi Sefa Bozkus Ozgur Korkmaz Sule Biyik Bayram Mehmet Ali Can Ebrahim Nasiri Koroush Jafar-Kazemi Melina Hosseini Shahin Maghoul Mansooreh Soleimani Abdollah Amini Mohamad Mahdi Hassanzade Mohammad Hossein Davari Tom Van Hoof Germano T Gomes Emmanuel Audenaert Koenraad Verstraete Ingrid Kerckaert Katharina D'Herde Brion Benninger Gil Hedley Florin Mihail Filipoiu Eugen Tarta Mihali Enyedi Cosmin Pantu Razvan Stanciulescu Cezary Skobowiat Jaroslaw Calka Mariusz Majewski Maryam Rezaian Akbar Yaghoobfar Somayeh Hamedi T Shomali

Surg Radiol Anat 2009 Sep;31 Suppl 1:95-229

Division of Histology, Department of Basic Sciences, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran.

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September 2009

The prognostic importance of trauma scoring systems in pediatric patients.

Pediatr Surg Int 2009 Jan 14;25(1):25-30. Epub 2008 Nov 14.

Department of Pediatric Surgery, School of Medicine, Afyon Kocatepe University, Cocuk Cerrahisi AD, 03200, Afyon, Turkey.

Purpose: Traumas are among important causes of morbidity and mortality in the pediatric group. Our aim was to evaluate the predicting effects of general trauma scores on mortality and morbidity rates.

Methods: The files of 74 patients, who were admitted to our hospital with trauma between the years 2006 and 2008, were retrospectively investigated. Patients' ages, sex, types of trauma, the time between the trauma and entrance to the hospital, vital and laboratory findings, length of hospital stay, length of intensive care unit (ICU) stay, surgical interventions, the organs affected by the trauma, morbidity, and mortality rates were recorded., glasgow coma scale (GCS), abbreviated injury scale (AIS), trauma score-injury severity score (TRISS), revised trauma score (RTS), injury severity score (ISS), pediatric trauma score (PTS), specific trauma scores for lung, liver, and spleen were calculated using the data in the files.

Results: The mean age of patients was 7.0+/-4.34 (1-16) years and 50% of them were men. The types of the trauma were blunt in 66 (89.2%) patients, penetrating in 5 (6.8%) patients and injury due to gun shot in 3 (4.1%) patients. The mean time between the trauma and entrance to the emergency service was 80.40+/-36.67 (10-120) min. Emergency operation and elective surgery was performed in 13 (17%) and 20 (27%) patients, respectively. The mean length of hospitalization was 4.50+/-7.93 (1-35) days.Seven (9.5%) patients needed ICU. The morbidity and mortality rates were 60.8% (n=45) and 2.7% (n=2), respectively. AIS, ISS, TRISS and PTS were independent predictors of morbidity (p<0.05). AIS and ISS were independent predictors of the length of hospital stay (p<0.05). RTS, TRISS, ISS and PTS were independent predictors of the need for ICU (p<0.05). Among laboratory findings, blood glucose, AST and ALT were found to be independent predictors of liver trauma.

Conclusion: ISS was found to be more valuable than other trauma scoring systems for prognostic evaluation of pediatric trauma patients. On the other hand, blood glucose, AST, and ALT are easily available, cheap, and valuable alternative laboratory findings in prognostic evaluation.
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January 2009