Publications by authors named "Yuki Hitomi"

58Publications

Inhibitory effects of biseokeaniamide A against lipopolysaccharide-induced signal transduction.

Bioorg Med Chem Lett 2020 06 28;30(11):127069. Epub 2020 Feb 28.

Department of Chemistry and Life Science, School of Advanced Engineering, Kogakuin University, 2665-1 Nakano, Hachioji, Tokyo 192-0015, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2020.127069DOI Listing
June 2020

Support Vector Machine model for hERG inhibitory activities based on the integrated hERG database using descriptor selection by NSGA-II.

Sci Rep 2019 08 21;9(1):12220. Epub 2019 Aug 21.

RIKEN Center for Life Science Technologies, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, 230-0045, Japan.

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http://dx.doi.org/10.1038/s41598-019-47536-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704061PMC
August 2019

Detection of the novel HLA-A allele, HLA-A*02:01:01:58, in a Japanese individual.

HLA 2019 11 16;94(5):435-436. Epub 2019 Aug 16.

Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1111/tan.13657DOI Listing
November 2019

Discovery of the novel HLA-B allele, HLA-B*51:01:01:36 in a Japanese individual.

HLA 2019 11 20;94(5):445-447. Epub 2019 Aug 20.

Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1111/tan.13658DOI Listing
November 2019

Identification of the novel HLA-DQB1 allele, HLA-DQB1*05:03:01:04, in a Japanese individual.

HLA 2019 11 20;94(5):466-468. Epub 2019 Aug 20.

Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1111/tan.13654DOI Listing
November 2019

HLA-VBSeq v2: improved HLA calling accuracy with full-length Japanese class-I panel.

Hum Genome Var 2019 19;6:29. Epub 2019 Jun 19.

1Graduate School of Information Sciences, Tohoku University, Sendai, Miyagi Japan.

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http://dx.doi.org/10.1038/s41439-019-0061-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584547PMC
June 2019

Analysis of whole Y-chromosome sequences reveals the Japanese population history in the Jomon period.

Sci Rep 2019 06 17;9(1):8556. Epub 2019 Jun 17.

Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, 113-0033, Japan.

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http://dx.doi.org/10.1038/s41598-019-44473-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572846PMC
June 2019

POGLUT1, the putative effector gene driven by rs2293370 in primary biliary cholangitis susceptibility locus chromosome 3q13.33.

Sci Rep 2019 01 14;9(1):102. Epub 2019 Jan 14.

Clinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Omura, Japan.

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http://dx.doi.org/10.1038/s41598-018-36490-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331557PMC
January 2019

Construction of an integrated database for hERG blocking small molecules.

PLoS One 2018 6;13(7):e0199348. Epub 2018 Jul 6.

Center for Life Science Technologies, RIKEN, Suehiro-cho, Tsurumi-ku, Yokohama City, Kanagawa, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199348PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034787PMC
December 2018

Significance of functional disease-causal/susceptible variants identified by whole-genome analyses for the understanding of human diseases.

Proc Jpn Acad Ser B Phys Biol Sci 2017 ;93(9):657-676

Department of Human Genetics, Graduate School of Medicine, the University of Tokyo.

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http://dx.doi.org/10.2183/pjab.93.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743846PMC
June 2018

Identification of pyrrolo[2,3-d]pyrimidines as potent HCK and FLT3-ITD dual inhibitors.

Bioorg Med Chem Lett 2017 11 7;27(22):4994-4998. Epub 2017 Oct 7.

Drug Discovery Chemistry Platform Unit, RIKEN Center for Life Science Technologies, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2017.10.012DOI Listing
November 2017

Principal contribution of HLA-DQ alleles, DQB1*06:04 and DQB1*03:01, to disease resistance against primary biliary cholangitis in a Japanese population.

Sci Rep 2017 09 11;7(1):11093. Epub 2017 Sep 11.

Clinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center and Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Omura, 856-8562, Japan.

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http://dx.doi.org/10.1038/s41598-017-11148-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593890PMC
September 2017

Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen.

Bioorg Med Chem 2017 08 16;25(16):4259-4264. Epub 2017 Jun 16.

Drug Discovery Computational Chemistry Platform Unit, RIKEN Center for Life Science Technologies, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2017.05.053DOI Listing
August 2017

Genome-wide association studies identify PRKCB as a novel genetic susceptibility locus for primary biliary cholangitis in the Japanese population.

Hum Mol Genet 2017 02;26(3):650-659

Clinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Omura, Japan.

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http://dx.doi.org/10.1093/hmg/ddw406DOI Listing
February 2017

Human primary biliary cirrhosis-susceptible allele of rs4979462 enhances TNFSF15 expression by binding NF-1.

Hum Genet 2015 Jul 22;134(7):737-47. Epub 2015 Apr 22.

Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan,

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http://dx.doi.org/10.1007/s00439-015-1556-3DOI Listing
July 2015

De novo mutations in epileptic encephalopathies.

Nature 2013 Sep 11;501(7466):217-21. Epub 2013 Aug 11.

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http://dx.doi.org/10.1038/nature12439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773011PMC
September 2013

Prediction of ligand-induced structural polymorphism of receptor interaction sites using machine learning.

J Chem Inf Model 2013 Mar 15;53(3):704-16. Epub 2013 Feb 15.

RIKEN Systems and Structural Biology Center , 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan.

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http://pubs.acs.org/doi/10.1021/ci300458g
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http://dx.doi.org/10.1021/ci300458gDOI Listing
March 2013

Human CD72 splicing isoform responsible for resistance to systemic lupus erythematosus regulates serum immunoglobulin level and is localized in endoplasmic reticulum.

BMC Immunol 2012 Dec 26;13:72. Epub 2012 Dec 26.

Laboratory of Immunology, School of Biomedical Science, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.

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http://dx.doi.org/10.1186/1471-2172-13-72DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565990PMC
December 2012

Insights from Pim1 structure for anti-cancer drug design.

Expert Opin Drug Discov 2012 Dec 25;7(12):1177-92. Epub 2012 Sep 25.

RIKEN Systems and Structural Biology Center, 1-7-22 Suehiro-cho, Tsurumi, Yokohama 230-0045, Japan.

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http://www.tandfonline.com/doi/full/10.1517/17460441.2012.72
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http://dx.doi.org/10.1517/17460441.2012.727394DOI Listing
December 2012

Application of support vector machine to three-dimensional shape-based virtual screening using comprehensive three-dimensional molecular shape overlay with known inhibitors.

J Chem Inf Model 2012 Apr 27;52(4):1015-26. Epub 2012 Mar 27.

RIKEN Systems and Structural Biology Center , 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan.

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http://pubs.acs.org/doi/10.1021/ci200562p
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http://dx.doi.org/10.1021/ci200562pDOI Listing
April 2012

Prediction of sites of metabolism in a substrate molecule, instanced by carbamazepine oxidation by CYP3A4.

Bioorg Med Chem 2012 Jan 8;20(2):775-83. Epub 2011 Dec 8.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

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http://dx.doi.org/10.1016/j.bmc.2011.12.004DOI Listing
January 2012

Inosine triphosphate protects against ribavirin-induced adenosine triphosphate loss by adenylosuccinate synthase function.

Gastroenterology 2011 Apr 1;140(4):1314-21. Epub 2011 Jan 1.

Center for Human Genome Variation, School of Medicine, Duke University, Durham, North Carolina, USA.

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http://dx.doi.org/10.1053/j.gastro.2010.12.038DOI Listing
April 2011

Mechanism of the decrease in catalytic activity of human cytochrome P450 2C9 polymorphic variants investigated by computational analysis.

J Comput Chem 2010 Nov;31(15):2746-58

Department of Physical Chemistry, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263-8522, Japan.

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http://dx.doi.org/10.1002/jcc.21568DOI Listing
November 2010

A functional polymorphism in IL-18 is associated with severity of bronchial asthma.

Am J Respir Crit Care Med 2009 Dec 10;180(11):1048-55. Epub 2009 Sep 10.

Laboratory for Respiratory Diseases, Center for Genomic Medicine, Institute of Physical and Chemical Research (RIKEN, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.

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http://dx.doi.org/10.1164/rccm.200905-0652OCDOI Listing
December 2009

[Bronchial asthma and genes of the innate immunity].

Arerugi 2009 Jul;58(7):766-71

Laboratory for Respiratory Diseases, Center for Genomic Medicine (CGM), RIKEN.

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July 2009

An epoxidation mechanism of carbamazepine by CYP3A4.

Bioorg Med Chem 2008 May 10;16(9):5134-48. Epub 2008 Mar 10.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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http://dx.doi.org/10.1016/j.bmc.2008.03.023DOI Listing
May 2008

Predicting human liver microsomal stability with machine learning techniques.

J Mol Graph Model 2008 Feb 27;26(6):907-15. Epub 2007 Jun 27.

Research Planning and Coordination, Nagoya Laboratories, Pfizer Global Research and Development, Pfizer Inc., 5-2 Taketoyo, Aichi 470-2393, Japan.

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http://dx.doi.org/10.1016/j.jmgm.2007.06.005DOI Listing
February 2008

Implementation of pi-pi interactions in molecular dynamics simulation.

J Comput Chem 2007 Apr;28(6):1091-9

Department of Physical Chemistry, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263-8522, Japan.

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http://dx.doi.org/10.1002/jcc.20557DOI Listing
April 2007