Publications by authors named "Yuka Yamamoto"

197 Publications

Correlation of 4'-[methyl-C]-thiothymidine PET with Gd-enhanced and FLAIR MRI in patients with newly diagnosed glioma.

EJNMMI Res 2021 Apr 30;11(1):42. Epub 2021 Apr 30.

Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.

Purpose: To elucidate the biological association between tumor proliferation, tumor infiltration and neovascularization, we analyzed the association between volumetric information of 4'-[methyl-C]thiothymidine (4DST) positron emission tomography (PET) and fluid-attenuated inversion recovery (FLAIR) and T1-weighted gadopentetate dimeglumine (Gd)-enhanced magnetic resonance imaging (MRI), in patients with newly diagnosed glioma.

Methods: A total of 23 patients with newly diagnosed glioma who underwent both 4DST PET/CT and Gd-enhanced MRI before therapy were available for a retrospective analysis of prospectively collected data. The maximum standardized uptake value (SUVmax) for tumor (T) and the mean SUV for normal contralateral hemisphere (N) were calculated, and the tumor-to-normal (T/N) ratio was determined. Proliferative tumor volume (PTV) from 4DST PET and the volume of Gd enhancement (GdV) and hyperintense region on FLAIR (FLAIRV) from MRI were calculated.

Results: All gliomas but 3 diffuse astrocytomas and one anaplastic astrocytoma had 4DST uptake and Gd enhancement on MRI. There was no significant difference between PTV and GdV although the exact edges of the tumor differed in each modality. The FLAIRV was significantly larger than PTV (P < 0.001). Significant correlations between PTV and GdV (ρ = 0.941, P < 0.001) and FLAIRV (ρ = 0.682, P < 0.001) were found.

Conclusion: These preliminary results indicate that tumor proliferation assessed by 4DST PET is closely associated with tumor-induced neovascularization determined by Gd-enhanced MRI in patients with newly diagnosed glioma.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13550-021-00785-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087735PMC
April 2021

Clinical significance of PET angiography in Takayasu arteritis.

J Nucl Cardiol 2021 Apr 22. Epub 2021 Apr 22.

Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12350-021-02619-5DOI Listing
April 2021

Incidental F-FDG myocardial uptake revealed as physiological lesion by F-FLT PET/CT.

J Nucl Cardiol 2021 Apr 22. Epub 2021 Apr 22.

Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12350-021-02618-6DOI Listing
April 2021

Effect of quantitative values on shortened acquisition duration in brain tumor C-methionine PET/CT.

EJNMMI Phys 2021 Mar 31;8(1):34. Epub 2021 Mar 31.

Department of Radiology, Faculty of Medicine, Kagawa University, Kita-gun, Kagawa, 761-0793, Japan.

Background: The amount of signal decreases when the acquisition duration is shortened. However, it is not clear how this affects the quantitative values. This study aims to clarify the effect of acquisition time shortening in brain tumor PET/CT using C-methionine on the quantitative values.

Method: This study was a retrospective analysis of 30 patients who underwent clinical C-methionine PET/CT examination. PET images were acquired in list mode for 10 min. PET images of acquisition duration from 1 to 10 min with 1-min step were reconstructed. We examined the effect on the quantitative values of acquisition duration. We placed a volume of interest to include the entire tumor and regions of interest in the shape of a large crescent in the contralateral hemisphere in 5 contiguous axial slices as normal tissue. Quantitative values examined were maximum, peak, and mean standardized uptake values (SUVmax, SUVpeak, SUVmean), metabolic tumor volume (MTV), and maximum tumor to normal tissue ratio (TNRmax), with each duration compared to that with 10 min.

Results: SUVmax, MTV, and TNRmax showed the highest values due to the effects of statistical noise when the acquisition time was 1 min. These values were stable when the acquisition duration was > 6 min. SUVpeak and SUVmean showed mostly consistent values regardless of duration.

Conclusions: SUVmax, MTV, and TNRmax are affected by acquisition time. If the acquisition duration was > 6 min, the fluctuation could be suppressed within 5% in these quantitative values. However, SUVpeak was suggested to be a robust index regardless of the acquisition duration.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40658-021-00379-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012475PMC
March 2021

Potential utility of F-NaF PET/CT in cardiac amyloidosis.

J Nucl Cardiol 2021 Mar 21. Epub 2021 Mar 21.

Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12350-021-02585-yDOI Listing
March 2021

Multiple positron emission tomography tracers for use in the classification of gliomas according to the 2016 World Health Organization criteria.

Neurooncol Adv 2021 Jan-Dec;3(1):vdaa172. Epub 2020 Dec 7.

Department of Neurological Surgery, Kagawa University, Faculty of Medicine, Ikenobe, Miki-Cho, Kita-gun, Kagawa, Japan.

Background: The molecular diagnosis of gliomas such as isocitrate dehydrogenase (IDH) status (wild-type [wt] or mutation [mut]) is especially important in the 2016 World Health Organization (WHO) classification. Positron emission tomography (PET) has afforded molecular and metabolic diagnostic imaging. The present study aimed to define the interrelationship between the 2016 WHO classification of gliomas and the integrated data from PET images using multiple tracers, including F-fluorodeoxyglucose (F-FDG), C-methionine (C-MET), F-fluorothymidine (F-FLT), and F-fluoromisonidazole (F-FMISO).

Methods: This retrospective, single-center study comprised 113 patients with newly diagnosed glioma based on the 2016 WHO criteria. Patients were divided into 4 glioma subtypes (Mut, Codel, Wt, and glioblastoma multiforme [GBM]). Tumor standardized uptake value (SUV) divided by mean normal cortical SUV (tumor-normal tissue ratio [TNR]) was calculated for F-FDG, C-MET, and F-FLT. Tumor-blood SUV ratio (TBR) was calculated for F-FMISO. To assess the diagnostic accuracy of PET tracers in distinguishing glioma subtypes, a comparative analysis of TNRs and TBR as well as the metabolic tumor volume (MTV) were calculated by Scheffe's multiple comparison procedure for each PET tracer following the Kruskal-Wallis test.

Results: The differences in mean F-FLT TNR and F-FMISO TBR were significant between GBM and other glioma subtypes ( < .001). Regarding the comparison between Gd-T1WI volumes and F-FLT MTVs or F-FMISO MTVs, we identified significant differences between Wt and Mut or Codel ( < .01).

Conclusion: Combined administration of 4 PET tracers might aid in the preoperative differential diagnosis of gliomas according to the 2016 WHO criteria.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1093/noajnl/vdaa172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920529PMC
December 2020

Tc-HSA-DTPA Scintigraphy of Protein-Losing Gastroenteropathy Associated with Mixed Connective Tissue Disease Before and After Immunosuppressive Therapy.

Nucl Med Mol Imaging 2021 Feb 7;55(1):46-47. Epub 2021 Jan 7.

Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793 Japan.

We present a female in her sixties with mixed connective tissue disease who underwent Tc-human serum albumin diethylenetriaminepentaacetic acid (Tc-HSA-DTPA) scintigraphy to clarify the cause of generalized edema. Scintigraphy findings directed the diagnosis to protein-losing gastroenteropathy. Various disorders are known to be associated with protein-losing gastroenteropathy; however, mixed connective tissue disease is a rare cause. Tc-HSA-DTPA scintigraphy is helpful in the diagnosis and following the response to therapy of protein-losing gastroenteropathy.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13139-020-00678-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881066PMC
February 2021

Interim 4'-[methyl-C]-thiothymidine PET for predicting the chemoradiotherapeutic response in head and neck squamous cell carcinoma: comparison with [F]FDG PET.

EJNMMI Res 2021 Feb 10;11(1):13. Epub 2021 Feb 10.

Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.

Purpose: We investigated the potential of interim 4'-[methyl-C]thiothymidine ([C]4DST) PET for predicting the chemoradiotherapeutic response for head and neck squamous cell carcinoma (HNSCC), in comparison with 2-deoxy-2-[F]fluoro-D-glucose ([F]FDG) PET.

Methods: A total of 32 patients with HNSCC who underwent both [C]4DST and [F]FDG PET/CT before therapy (baseline) and at approximately 40 Gy point during chemoradiotherapy (interim) were available for a retrospective analysis of prospectively collected data. The baseline was treatment-naïve PET/CT scan as part of staging. The maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV) from [F]FDG PET or proliferative tumor volume (PTV) from [C]4DST PET, and total lesion glycolysis (TLG) from [F]FDG PET or total lesion proliferation (TLP) from [C]4DST PET were measured. MTV or PTV was defined as the volume with an SUVmax greater than 2.5. The differences in SUVmax (ΔSUVmax), MTV (ΔMTV) or PTV (ΔPTV) and TLG (ΔTLG) or TLP (ΔTLP) from baseline to interim PET scans were calculated. Patients without or with evidence of residual or recurrent disease at 3 months after completion of chemoradiotherapy were classified as showing a complete response (CR) and non-CR, respectively.

Results: All patients showed increased uptake in primary tumor on baseline [C]4DST and [F]FDG PET studies. All patients showed increased uptake on interim [F]FDG PET, whereas 18 patients showed no increased uptake on interim [C]4DST PET. After chemoradiotherapy, 25 patients were found to be in CR group and 7 to be in non-CR group. [C]4DST ΔSUVmax, ΔPTV, and ΔTLP for CR group showed significantly greater reductions than the corresponding values for non-CR group (P = 0.044, < 0.001, < 0.001, respectively). However, there were no significant differences in [F]FDG ΔSUVmax, ΔMTV, or ΔTLG between CR group and non-CR group. [C]4DST ΔMTV of -90 was the best cutoff value for the early identification of patients with non-CR.

Conclusion: These preliminary results suggest that interim [C]4DST PET might be useful for predicting the chemoradiotherapeutic response in patients with HNSCC, in comparison with [F]FDG PET.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13550-021-00749-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876213PMC
February 2021

Asia-inclusive global development of pevonedistat: Clinical pharmacology and translational research enabling a phase 3 multiregional clinical trial.

Clin Transl Sci 2021 Jan 27. Epub 2021 Jan 27.

Millennium Pharmaceuticals, Inc. (a wholly owned subsidiary of Takeda Pharmaceutical Company Limited), Cambridge, MA, USA.

The investigational NEDD8-activating enzyme inhibitor pevonedistat is being evaluated in combination with azacitidine versus single-agent azacitidine in patients with higher-risk myelodysplastic syndrome (higher-risk MDS), higher-risk chronic myelomonocytic leukemia (higher-risk CMML), or low-blast acute myeloid leukemia (AML) in a Phase 3 trial PANTHER. To support Asia-inclusive global development, we applied multiregional clinical trial (MRCT) principles of the International Conference on Harmonisation E17 guidelines by evaluating similarity in drug-related and disease-related intrinsic and extrinsic factors. A PubMed literature review (January 2000-November 2019) supported similarity in epidemiology of higher-risk MDS, AML, and CMML in Western and East Asian populations. Furthermore, the treatment of MDS/AML was similar in both East Asian and Western regions, with the same dose of azacitidine being the standard of care. Median overall survival in MDS following azacitidine treatment was generally comparable across regions, and the types and frequencies of molecular alterations in AML and MDS were comparable. Dose-escalation studies established the same maximum tolerated dose of pevonedistat in combination with azacitidine in Western and East Asian populations. Pevonedistat clearance was similar across races. Taken together, conservation of drug-related and disease-related intrinsic and extrinsic factors supported design of an Asia-inclusive Phase 3 trial and a pooled East Asian region. A sample size of ~ 30 East Asian patients (of ~ 450 randomized) was estimated as needed to demonstrate consistency in efficacy relative to the global population. This analysis is presented as an exemplar to illustrate application of clinical pharmacology and translational science principles in designing Asia-inclusive MRCTs.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/cts.12972DOI Listing
January 2021

Measurement of fetal automated fractional shortening using two-dimensional tracking in multiple centers.

J Med Ultrason (2001) 2021 Jan 11;48(1):83-90. Epub 2021 Jan 11.

Department of Obstetrics and Gynecology, Toho University Omori Medical Center, Tokyo, Japan.

Purpose: To establish a normal reference range for automated fractional shortening (Auto FS) in normal singleton fetuses measured at multiple centers.

Methods: This study was conducted from May 2017 to March 2019. It was undertaken on normal singleton fetuses. First, a four-chamber view of the fetal heart was recorded in the B-mode. Then, the region of interest was set on the edge of the ventricular septum and on the edge of the ventricular muscle at a point one-third away from the atrioventricular valve and toward the cardiac apex. Tracking was automatically performed. Values measured in the right ventricle were defined as R-Auto FS, and in the left ventricle as L-Auto FS. Furthermore, combined-Auto FS was defined as the measurement across both ventricles.

Results: A total of 442 normal fetuses were assessed. R-Auto FS decreased significantly with gestational age, and L-Auto FS showed a similar tendency (Spearman's correlation analysis: r =  - 0.415 and r =  - 0.252, respectively). Combined-Auto FS showed a similar decline as the gestational age increased (r =  - 0.451).

Conclusion: In this study, we succeeded in defining a reference Auto FS value not only at one institution but also multiple centers. This study suggests that Auto FS can be used clinically and effectively.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10396-020-01069-9DOI Listing
January 2021

Abnormal FDG Biodistribution in a Patient With Gitelman Syndrome.

Clin Nucl Med 2021 May;46(5):e264-e265

From the Department of Radiology, Faculty of Medicine, Kagawa University, Kagawa, Japan.

Abstract: Gitelman syndrome is an autosomal recessive renal tubulopathy. A 38-year-old woman was diagnosed with Gitelman syndrome. Eight years later, 18F-FDG PET/CT was performed to evaluate recurrence of endometrial cancer. FDG PET images showed an extremely abnormal FDG biodistribution. They showed decreased brain uptake, increased cardiac muscle uptake, and diffuse increased muscle and adipose tissue uptake. This pattern is similar to high insulin state; however, her glucose level was normal, and insulin level was very low.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLU.0000000000003437DOI Listing
May 2021

18F-Fluoromisonidazole PET in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease Presenting With Tumefactive Demyelinating Lesion.

Clin Nucl Med 2021 May;46(5):e258-e259

From the Departments of Radiology.

Abstract: Tumefactive demyelinating lesions have been appreciated as part of the clinical and radiological spectrum of myelin oligodendrocyte glycoprotein antibody-associated disease. A 63-year-old woman was followed up for myelin oligodendrocyte glycoprotein antibody-associated disease. Two years later, she presented with right facial paralysis. T2-weighted MRI scan demonstrated a high-signal-intensity area with edematous change in the right frontal lobe, and partial enhancement was shown on contrast-enhanced T1-weighted image. This contrast-enhanced area showed increased 18F-fluoromisonidazole uptake.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLU.0000000000003429DOI Listing
May 2021

Disease activity and response to therapy monitored by [F]FDG PET/CT using volume-based indices in IgG4-related disease.

EJNMMI Res 2020 Dec 9;10(1):153. Epub 2020 Dec 9.

Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.

Purpose: The efficiency of [F]FDG PET/CT using volume-based indices was evaluated to assess the disease activity and response to therapy in patients with immunoglobulin G4-related disease (IgG4-RD).

Methods: A total of 17 patients with IgG4-RD were examined with [F]FDG PET/CT before and during treatment. The lesion boundary was determined using a fixed threshold of standardized uptake value (SUV) ≥ 2.5. The highest maximum SUV (SUVmax) among all affected lesions was calculated for individual patients. We summed metabolic tumor volume (MTV) and total lesion glycolysis (TLG) of each affected lesion to generate a total MTV and total TLG. PET results were compared with those of serum IgG4 and soluble interleukin-2 receptor (sIL-2R) levels.

Results: The mean number of involved organs per patient was 3.8 as determined by [F]FDG uptake. The number of involved organs, total MTV and total TLG were significantly correlated with IgG4 (P = 0.046, < 0.001, < 0.001, respectively) and sIL-2R (P < 0.001, = 0.031, 0.031, respectively). According to the clinical assessments for therapy response, all patients were classified as improved. The SUVmax, total MTV, and total TLG during therapy were all significantly lower than those before therapy (all P < 0.001).

Conclusion: [F]FDG PET/CT is valuable for assessing the extent of multi-organ involvement before therapy and monitoring subsequent therapy in patients with IgG4-RD. [F]FDG PET/CT using volumetric indices correlated with serum IgG4 and sIL-2R levels.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13550-020-00743-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726066PMC
December 2020

Immune checkpoint inhibitor myocarditis mimicking Takotsubo cardiomyopathy on MPI.

J Nucl Cardiol 2020 Nov 25. Epub 2020 Nov 25.

Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12350-020-02444-2DOI Listing
November 2020

Liver Abscess With High 18F-FDG Uptake and No 18F-Fluorothymidine Uptake.

Clin Nucl Med 2021 Apr;46(4):e208-e209

From the Departments of Radiology.

Abstract: 18F-FDG accumulates not only in malignant lesions but also in infectious and inflammatory ones. 3'-deoxy-3'-18F-fluorothymidine (FLT) has been investigated as a promising PET tracer for evaluating tumor proliferating activity. We report a case of liver abscess during therapy of pancreatic cancer that underwent FDG PET/CT and FLT PET/CT studies. Although FDG PET/CT demonstrated several regions of increased uptake in the liver, FLT PET/CT showed no increased uptake in the liver.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLU.0000000000003372DOI Listing
April 2021

Whole exome sequencing of fetal structural anomalies detected by ultrasonography.

J Hum Genet 2021 May 3;66(5):499-507. Epub 2020 Nov 3.

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

The objective of this study was to evaluate the efficacy of whole exome sequencing (WES) for the genetic diagnosis of cases presenting with fetal structural anomalies detected by ultrasonography. WES was performed on 19 cases with prenatal structural anomalies. Genomic DNA was extracted from umbilical cords or umbilical blood obtained shortly after birth. WES data were analyzed on prenatal phenotypes alone, and the data were re-analyzed after information regarding the postnatal phenotype was obtained. Based solely on the fetal phenotype, pathogenic, or likely pathogenic, single nucleotide variants were identified in 5 of 19 (26.3%) cases. Moreover, we detected trisomy 21 in two cases by WES-based copy number variation analysis. The overall diagnostic rate was 36.8% (7/19). They were all compatible with respective fetal structural anomalies. By referring to postnatal phenotype information, another candidate variant was identified by a postnatal clinical feature that was not detected in prenatal screening. As detailed phenotyping is desirable for better diagnostic rates in WES analysis, we should be aware that fetal phenotype is a useful, but sometimes limited source of information for comprehensive genetic analysis. It is important to amass more data of genotype-phenotype correlations, especially to appropriately assess the validity of WES in prenatal settings.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s10038-020-00869-8DOI Listing
May 2021

Cardiac sympathetic denervation in coronary artery fistula.

J Nucl Cardiol 2020 Oct 9. Epub 2020 Oct 9.

Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12350-020-02374-zDOI Listing
October 2020

Evaluation of the Therapeutic Response by 11C-Methionine PET in a Case of Neuro-Sweet Disease.

Clin Nucl Med 2020 Dec;45(12):962-964

From the Departments of Radiology.

Sweet disease is a multisystem inflammatory disorder characterized by fever, cutaneous erythematous plaques, and aseptic neutrophilic infiltration of various organs. Neuro-Sweet disease is a known rare central nervous system complication of Sweet disease. A 67-year-old Japanese woman who was diagnosed with neuro-Sweet disease underwent C-methionine (C-MET) PET. C-MET PET revealed increased accumulation in the affected brain tissues. After steroid therapy, she became asymptomatic, and a follow-up C-MET PET scan showed disappearance of the abnormal uptake of C-MET.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLU.0000000000003324DOI Listing
December 2020

Reverse redistribution on Tl SPECT in a patient with coronary artery ectasia.

J Nucl Cardiol 2020 Sep 30. Epub 2020 Sep 30.

Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagwa, 761-0793, Japan.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12350-020-02361-4DOI Listing
September 2020

Branch pulmonary artery Doppler parameters predict early survival-non-survival in premature rupture of membranes.

J Perinatol 2020 12 25;40(12):1821-1827. Epub 2020 Sep 25.

Fetal & Neonatal Cardiology Program, Pediatric Cardiology, Women's & Children's Health Research Institute & Mazankowski Heart Institute, University of Alberta, Edmonton, AB, Canada.

Background: Preterm premature rupture of membrane (pPROM) leads to high neonatal mortality due in part to severe lung hypoplasia (LH). In other causes of severe LH, fetal echo-based parameters of smaller branch pulmonary arteries (PA), shorter acceleration to ejection time ratio (AT/ET), increased peak early diastolic reverse flow (PEDRF), and higher pulsatility index (PI) are predictive of worse neonatal outcome. We sought to determine whether these parameters correlated with worse clinical outcome in pPROM.

Methods: Twenty-five pregnancies complicated by pPROM were prospectively recruited. Fetal echocardiography was used to evaluate branch PA diameters and Doppler parameters. Clinical records were reviewed. Fetal echo findings were compared between early survivors and non-survivors.

Results: Of 25 pPROM cases, 5 had early neonatal demise (≤3 days) due to respiratory insufficiency. While gestational age at pPROM, fetal echo, and at birth did not differ, amniotic fluid index (AFI) was significantly lower in early non-survivors compared to survivors (p = 0.05). No difference was observed in PA diameter, PEDRF, or PI; however, branch PA AT/ET was significantly shorter in non-survivors (right PA median 0.12 (0.11-0.16) vs. survivors 0.17 (0.14-0.21), p = 0.046 and left PA 0.12 (0.09-0.13) vs. survivors 0.16 (0.11-0.21), p = 0.042).

Conclusions: We found a significantly lower AFI and shorter fetal bilateral branch PA AT/ET to be associated with early neonatal demise following pPROM.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41372-020-00817-6DOI Listing
December 2020

Focal myocardial perfusion abnormalities in cardiac amyloidosis as compared with CMR, bone scintigraphy, and C-PiB PET.

J Nucl Cardiol 2020 Sep 9. Epub 2020 Sep 9.

Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12350-020-02349-0DOI Listing
September 2020

A preliminary study of relationship among the degree of internal carotid artery stenosis, wall shear stress on MR angiography and F-FDG uptake on PET/CT.

J Nucl Cardiol 2020 Aug 2. Epub 2020 Aug 2.

Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.

Background: This preliminary study was undertaken to evaluate relationship among the degree of internal carotid artery (ICA) stenosis, wall shear stress (WSS) by computational fluid dynamics (CFD) on magnetic resonance angiography (MRA) and F-FDG uptake of ICA on PET/CT.

Methods: A total of 40 carotid arteries in 20 patients with carotid atherosclerotic disease were examined with MRA and F-FDG PET/CT. Atherosclerotic risk factors were assessed in all patients. Degree of ICA stenosis was calculated according to NASCET method. CFD analysis was performed and maximum WSS (WSSmax) was measured. F-FDG uptake in ICA was quantified using maximum target-to-blood pool ratio (TBRmax).

Results: Atherosclerotic risk factors did not affect imaging findings. There were significant correlations between WSSmax and degree of ICA stenosis (ρ = .81, P < .001), WSSmax and TBRmax (ρ = .64, P < .001), and TBRmax and degree of ICA stenosis (ρ = .50, P = .001).

Conclusions: These preliminary results indicate that there may be significant correlations among the degree of ICA stenosis, WSSmax and TBRmax in patients with carotid artery stenosis.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12350-020-02300-3DOI Listing
August 2020

An analysis of anatomical variations of the left pulmonary artery of the interlobar portion for lung resection by three-dimensional CT pulmonary angiography and thin-section images.

Jpn J Radiol 2020 Dec 29;38(12):1158-1168. Epub 2020 Jul 29.

Faculty of Medicine, Department of Radiology, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.

Purpose: The purpose of the present study was to analyze the left pulmonary artery (LPA) branching pattern of the interlobar portion using three-dimensional CT pulmonary angiography (3D-CTPA) and thin-section CT images, and to attempt to diagrammatize these patterns.

Materials And Methods: The study included 320 patients suspected of having lung cancer of the left upper/lower lobe who underwent CTPA. The number and origin of the LPA branches of the interlobar portion, A1 + 2c, A6, and lingular artery from pars interlobaris (PI), were identified meticulously using 3D-CTPA and thin-section images. We then diagrammatized the identified LPA branching patterns of the interlobar portion.

Results: The diagrammatized LPA branching patterns of the interlobar portion were broadly classified into seven types in the order of bifurcation from proximal to distal. Type 1 was the most frequent (120/320, 37.5%). PI originated from the lower portion, that is, from A8 or the common trunk of A8 and A9 in 95 cases (29.7%). We could also precisely diagrammatize the LPA branching patterns of the interlobar portion into 85 types in all 320 patients.

Conclusion: 3D-CTPA and thin-section images provided precise preoperative information regarding the LPA branching patterns of the interlobar portion.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11604-020-01024-1DOI Listing
December 2020

Pure 9p duplication syndrome with aplasia of the middle phalanges of the fifth fingers.

Eur J Med Genet 2020 Oct 18;63(10):104005. Epub 2020 Jul 18.

Department of Obstetrics and Gynecology, Juntendo University Faculty of Medicine, Tokyo, Japan.

9p duplication syndrome is a common congenital anomaly syndrome with specific facial features, mental and developmental retardations, and characteristic fingers. Pure 9p duplication without other chromosomal structural variations is very rare. It has recently been reported that cases with partial 9p duplication including SMARCA2 have phenotypes overlapping with Coffin-Siris syndrome (CSS). Herein, we present a family with pure 9p duplication syndrome in which phenotypes partially characteristic of CSS were identified. In one of two siblings, X-ray examination revealed hypoplasia of the distal phalanges of the fifth fingers, aplasia of the middle phalanges of the fifth fingers, and aplasia of the distal phalanges of the second to fifth toes. In pure 9p duplication together with our one affected case, 9 out of 14 cases (64.3%), excluding cases whose clinical data were unavailable, presented the absence or hypoplasia of the middle phalanges of fingers or toes. Interestingly, there are no reports on CSS with aplasia or hypoplasia of the middle phalanx. Therefore, this family might suggest that the aplasia or hypoplasia of the middle phalanges of the fifth fingers or toes is a distinct finding that can distinguish between pure 9p duplication and CSS.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmg.2020.104005DOI Listing
October 2020

18F-THK5351 PET Can Identify Lesions of Acute Traumatic Brain Injury.

Clin Nucl Med 2020 Nov;45(11):e491-e492

From the Departments of Radiology.

A 67-year-old woman sustained a mild traumatic brain injury (TBI) in a traffic accident and had an initial Glasgow Coma Scale score of 13. She underwent F-THK5351 PET 18 days after TBI. Fused F-THK5351 PET/MRI showed that the location of F-THK5351 accumulations corresponded anatomically to intraparenchymal lesions of acute TBI on MRI. F-THK5351 reportedly binds to monoamine oxidase B highly expressed in astrocytes. Furthermore, TBI induces reactive astrogliosis or blood-brain barrier breakdown included in primary brain injury. Therefore, F-THK5351 uptake may represent primary brain injury in acute TBI lesions.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLU.0000000000003165DOI Listing
November 2020

High Salt Intake Impairs Erectile Function in Salt-Sensitive Rats Through Mineralocorticoid Receptor Pathway Beyond Its Effect on Blood Pressure.

J Sex Med 2020 07;17(7):1280-1287

Department of Clinical Pharmaceutics, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan; Department of Hospital Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan. Electronic address:

Background: High salt intake is a risk factor for hypertension, which can potentially lead to erectile dysfunction (ED); however, the underlying pathological mechanisms remain unclear.

Aim: To investigate whether erectile function is directly impaired by high salt intake and whether selective inhibition of mineralocorticoid receptor (MR) could provide protection from ED.

Methods: 6-week-old male Dahl salt-sensitive rats were randomly divided into 3 groups: normal diet (0.3% NaCl; control, n = 8), high-salt diet (8% NaCl; HS, n = 8), and high-salt diet plus eplerenone (HS + EPL, n = 11). HS + EPL rats were orally administered daily doses of EPL (75 mg/kg) for 6 weeks; control and HS rats received purified water on the same schedule.

Outcomes: At the end of the study period, erectile function was evaluated by measuring intracavernosal pressure and mean arterial pressure after cavernous nerve stimulation. Serum levels of asymmetric dimethylarginine and L-arginine were determined using ultraperformance liquid chromatography-tandem mass spectrometry. Quantitative PCR was used to assess the expression of MR, inflammation, and oxidative stress markers (nicotinamide adenine dinucleotide phosphate oxidase-1/4, p22, interleukin-6, and superoxide dismutase-1), and protein arginine N-methyltransferase-1.

Results: The intracavernosal pressure/mean arterial pressure ratio was significantly lower, whereas systolic blood pressure, MR expression, serum asymmetric dimethylarginine levels, oxidative stress, and levels of inflammatory biomarkers were significantly higher in HS rats than in control rats (P < .05). EPL administration significantly improved each of these parameters except systolic blood pressure and MR expression. No significant intergroup differences were observed for L-arginine and superoxide dismutase-1 levels.

Clinical Translation: Our results provide a rationale for the need of salt restriction and the use of selective MR inhibitors in prophylaxis or treatment of ED in men consuming a high-salt diet.

Strengths & Limitations: We are the first to report that the adverse impact of high salt intake on erectile function is mediated via MR activation, independent of its effect on blood pressure. A major limitation of this study is that responses of salt-resistant rats were not studied.

Conclusions: High salt intake directly impaired erectile function in Dahl salt-sensitive rats, whereas selective MR inhibition ameliorated this effect. Kishimoto T, Kataoka T, Yamamoto Y, et al. High Salt Intake Impairs Erectile Function in Salt-Sensitive Rats Through Mineralocorticoid Receptor Pathway Beyond Its Effect on Blood Pressure. J Sex Med 2020;17:1280-1287.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsxm.2020.04.384DOI Listing
July 2020

Left ventricular thrombus on F-FDG and F-FLT PET/CT in a patient with cardiac sarcoidosis.

J Nucl Cardiol 2020 Jun 12. Epub 2020 Jun 12.

Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Kita-gun, Miki-cho, Kagawa, 761-0793, Japan.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12350-020-02225-xDOI Listing
June 2020

Hypertrophic cardiomyopathy incidentally detected by 99mTc-HAS-D scintigraphy.

J Nucl Cardiol 2020 May 18. Epub 2020 May 18.

Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12350-020-02189-yDOI Listing
May 2020

Diagnostic value of PET/CT with C-methionine (MET) and F-fluorothymidine (FLT) in newly diagnosed glioma based on the 2016 WHO classification.

EJNMMI Res 2020 May 7;10(1):44. Epub 2020 May 7.

Department of Neurological Surgery, Kagawa University, Faculty of Medicine, Miki-cho, Kagawa, Japan.

Background: The molecular features of isocitrate dehydrogenase (IDH) mutation and chromosome 1p and 19q (1p/19q) codeletion status have pivotal role for differentiating gliomas and have been integrated in the World Health Organization (WHO) classification in 2016. Positron emission tomography (PET) with 3'-deoxy-3'-[F]fluorothymidine (FLT) has been used to evaluate tumour grade and proliferative activity and compared with L-[methyl-C]-methionine (MET) in glioma patients. Herein, we evaluated tracer uptakes of MET-PET/CT and FLT-PET/CT for differentiating glioma based on the 2016 WHO classification especially in relation to IDH1 mutation status.

Methods: In total, 81 patients with newly diagnosed supratentorial glioma were enrolled in this study. They underwent PET/CT studies with MET and FLT before surgery. The molecular features and histopathological diagnosis based on the 2016 WHO classification were determined using surgical specimens. The ratios of the maximum standardized uptake value (SUV) of the tumours to the mean SUV of the contralateral cortex (T/N ratios) were calculated on MET-PET/CT and FLT-PET/CT images.

Results: The mean T/N ratios of MET-PET/CT and FLT-PET/CT in IDH1-wildtype tumours were significantly higher than those in IDH1-mutant tumours (P < 0.001 and P < 0.001, respectively). Receiver operating characteristic analysis for differentiating IDH1 mutation status showed that the area under the curve of the FLT T/N ratio was significantly larger than that of the MET T/N ratio (P < 0.01). The mean T/N ratio of FLT-PET/CT in IDH1-wildtype tumours was significantly higher than that in IDH1-mutant tumours among grade II and III gliomas (P = 0.005), but this was not the case for MET-PET/CT. Both MET-PET/CT and FLT-PET/CT were able to distinguish between grade II and III gliomas in IDH1-mutant tumours (P = 0.002 and P < 0.001, respectively), but only FLT-PET/CT was able to distinguish between grade III and IV gliomas in IDH1-wildtype tumours (P = 0.029).

Conclusion: This study showed that FLT-PET/CT can be used to determine the IDH1 mutation status and evaluate glioma grade more accurately than MET-PET/CT. FLT-PET/CT can improve glioma differentiation based on the 2016 WHO classification, but caution must be paid for tumours without contrast enhancement and further studies should be conducted with more cases.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13550-020-00633-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205963PMC
May 2020

Structure and diversity of 13S globulin zero-repeat subunit, the trypsin-resistant storage protein of common buckwheat ( M.) seeds.

Breed Sci 2020 Mar 17;70(1):118-127. Epub 2019 Dec 17.

Graduate School of Agriculture, Kyoto University, Kitashirakawa, Kyoto 606-8502, Japan.

The zero-repeat subunit of 13S globulin, which lacks tandem repeat inserts, is trypsin-resistant and suggested to show higher allergenicity than the other subunits in common buckwheat ( Moench). To evaluate allelic variations and find novel alleles, the diversity of the zero-repeat genes was examined for two Japanese elite cultivars and 15 Pakistani landraces. The results demonstrated that two new alleles and , plus three additional new alleles , , and , were identified besides the already-known , , and alleles. In the Pakistani landraces, was the most dominant allele (0.60-0.88 of allele frequency) in all except one landrace, where was the most dominant allele (0.50 of allele frequency). Similar to , the alleles and had extra ~200 bp MITE-like sequences around the stop codon. Secondary structure predictions of a sense strand demonstrated that the extra ~200 bp sequences of , , and can form rigid hairpin structures with free energies of -78.95, -67.06, and -29.90 kcal/mol, respectively. These structures may affect proper transcription and/or translation. In the homozygous line, no transcript of a zero-repeat gene was detected, suggesting the material would be useful for developing hypoallergenic buckwheat.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1270/jsbbs.19017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180142PMC
March 2020