Publications by authors named "Yuka Sogabe"

12 Publications

  • Page 1 of 1

Clinical features and symptoms of IgG4-related ophthalmic disease: a multicenter study.

Jpn J Ophthalmol 2021 Sep 19;65(5):651-656. Epub 2021 Jun 19.

Kanazawa University, Kanazawa, Japan.

Purpose: The aim of this study was to elucidate the clinical features and symptoms of IgG4-related ophthalmic disease (IgG4-ROD).

Study Design: Retrospective, multicenter study.

Methods: The medical charts of 378 patients with IgG4-ROD diagnosed at 9 hospitals in Japan were reviewed. The demographic profiles, clinical findings, and ocular symptoms of the patients were analyzed.

Results: On the basis of the diagnostic criteria for IgG4-ROD, the diagnosis was definite in 261 patients (69%), probable in 45 patients (12%), and possible in 72 patients (19%). The patients' mean age at the time of diagnosis was 60.6 ± 13.9 years; 195 (52%) were male. The mean IgG4 serum level at the time of the initial diagnosis was 578.9 mg/dL. Imaging studies showed pathologic lesions as follows: lesions in the lacrimal glands (86%), extraocular muscles (21%), trigeminal nerve (20%), and eyelids (12%); isolated orbital mass (11%); diffuse orbital lesion (8%); lesion in the perioptic nerve (8%); and lesion in the sclera (1%). The ophthalmic symptoms included dry eye (22%), diplopia (20%), decreased vision (8%), and visual field defects (5%). IgG4-ROD with extraocular lesions was observed in 182 patients (48%).

Conclusion: Although the lacrimal glands are well known to be the major pathologic site of IgG4-ROD, various ocular tissues can be affected and cause ophthalmic symptoms including visual loss.
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http://dx.doi.org/10.1007/s10384-021-00847-3DOI Listing
September 2021

Treatment outcomes of IgG4-producing marginal zone B-cell lymphoma: a retrospective case series.

Int J Hematol 2020 Dec 12;112(6):780-786. Epub 2020 Aug 12.

Department of Hematology and Oncology, Okayama University Hospital, 2-5-1, Shikata-cho Kita-ku, Okayama, 700-8558, Japan.

IgG4-producing marginal zone B-cell lymphomas (MZLs) have been recently proposed as a subtype of MZLs. Despite the abundant literature on pathophysiological features of this type of lymphoma, only a few retrospective studies pertaining to the treatment outcomes have been reported, and its prognosis remains unclear. We retrospectively analyzed seven patients with IgG4-producing MZLs diagnosed at our institute, with specific reference to treatment and outcomes. The median age was 69.0 years (55-79), and all were males. The median follow-up period was 66.6 months (8-121). All patients had localized disease; four patients had tumors of the ocular adnexa, whereas two had retroperitoneal tumors. Five patients were treated with irradiation (30 Gy/15 fr) (n = 4) or surgery (n = 1), resulting in tumor reduction. Two patients were treated by chemotherapy or irradiation. Among them, one commenced rituximab monotherapy, which led to an inadequate reduction of the tumor. Subsequent irradiation induced complete response (CR). The other patient experienced repeated relapses during follow-up and finally achieved CR by combination chemotherapy. Treatment was well tolerated in all cases, and none of the patients showed disease progression at the last follow-up visit. Our results indicate that the standard treatments for MZLs are generally appropriate for IgG4-producing MZL.
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http://dx.doi.org/10.1007/s12185-020-02968-wDOI Listing
December 2020

Tubulointerstitial Nephritis and Uveitis Caused by Sjögren Syndrome Without Dryness.

J Clin Rheumatol 2020 Jul 24. Epub 2020 Jul 24.

From the Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama.

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http://dx.doi.org/10.1097/RHU.0000000000001505DOI Listing
July 2020

Wernicke encephalopathy.

CMAJ 2020 02;192(6):E143

Departments of General Internal Medicine (Fujikawa) and Ophthalmology (Sogabe), Mitoyo General Hospital, Kanonji, Kagawa, Japan.

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http://dx.doi.org/10.1503/cmaj.190998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012630PMC
February 2020

Septic cavernous sinus thrombosis: potentially fatal conjunctival hyperemia.

Intensive Care Med 2019 05 30;45(5):692-693. Epub 2018 Jul 30.

Department of Ophthalmology, Mitoyo General Hospital, 708 Himehama Toyohama, Kanonji, Kagawa, 769-1695, Japan.

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http://dx.doi.org/10.1007/s00134-018-5322-6DOI Listing
May 2019

Sometimes the Eyes Say More Than the Mouth.

Am J Med 2017 Dec 7;130(12):e553. Epub 2017 Sep 7.

Department of Ophthalmology, Mitoyo General Hospital, Kanonji, Kagawa, Japan.

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http://dx.doi.org/10.1016/j.amjmed.2017.08.024DOI Listing
December 2017

Kayser-Fleischer ring: Wilson's disease.

QJM 2017 Aug;110(8):531

Mitoyo General Hospital, 708, Himehama, Toyohama-cho, Kanonji-city, Kagawa 769-1695, Japan.

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http://dx.doi.org/10.1093/qjmed/hcx094DOI Listing
August 2017

Ocular adnexal marginal zone lymphoma arising in a patient with IgG4-related ophthalmic disease.

Mod Rheumatol 2019 Mar 11;29(2):383-387. Epub 2016 Aug 11.

a Department of Pathology , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan.

A 41-year-old man was diagnosed with immunoglobulin G4-related disease (IgG4-RD) in both eyelids 4 years ago and exhibited good response to steroid therapy. However, rapid swelling of the right eyelid lesion was recently observed. As IgG4-RD progression was suspected, biopsy was performed. Although the histology was consistent with IgG4-RD, the infiltrating large atypical lymphoid cells showed immunoglobulin light-chain restriction and IgH gene rearrangement. Consequently, he was diagnosed with extranodal marginal zone lymphoma with abundant IgG4-positive cells.
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http://dx.doi.org/10.1080/14397595.2016.1216733DOI Listing
March 2019

Location and frequency of lesions in patients with IgG4-related ophthalmic diseases.

Graefes Arch Clin Exp Ophthalmol 2014 Mar 3;252(3):531-8. Epub 2014 Jan 3.

Department of Ophthalmology, Mitoyo General Hospital, 708, Himehama, Toyohama-cho, Kanonji, Kagawa, 7691695, Japan,

Background: It is well-known that the lacrimal gland (LG) may be affected in IgG4-related ophthalmic disease (IgG4ROD). Recently, IgG4-related ophthalmic lesions other than those of the lacrimal gland have been reported. However, no study to date has revealed the details of these lesions. This study was conducted to evaluate the location and frequency of lesions found in conjunction with IgG4ROD using radiological imaging.

Methods: Radiological images and clinical records of 65 patients collected from seven institutions in Japan were reviewed retrospectively. All patients had been pathologically diagnosed with IgG4ROD. Patients of mucosa-associated lymphoid tissue lymphoma associated with IgG4-related lesions were excluded. Orbital magnetic resonance imaging or computed tomography findings were evaluated.

Results: Of the 65 patients, 31 (47.7 %) had lesions involving the LG alone, whereas 34 (52.3 %) had lesions involving the areas other than LG, including eight patients who had lesions without any LG involvement. IgG4-related ophthalmic lesions included LG enlargement in 57 patients (87.7 %), trigeminal nerve branch enlargement in 25 (38.5 %), extraocular muscle enlargement in 16 (24.6 %), diffuse orbital fat lesions in 15 (23.1 %), orbital mass lesions in 11 (16.9 %), eyelid lesions in eight (12.3 %), and nasolacrimal duct lesion in one (1.5 %). Six patients (9.2 %) presented with visual disturbance due to optic nerve disturbance, eight (12.3 %) with a restriction of ocular movement, and 19 (29.2 %) with exophthalmos.

Conclusions: Thirty-four (52.3 %) of the 65 IgG4ROD patients had lesions in areas other than LG. Lesions were found in the trigeminal nerve branch including pterygopalatine fossa, extraocular muscles, orbital fat, eyelid, and nasolacrimal duct.
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http://dx.doi.org/10.1007/s00417-013-2548-4DOI Listing
March 2014

A case of conjunctival follicular lymphoma mimicking mucosa-associated lymphoid tissue lymphoma.

J Clin Exp Hematop 2013 ;53(1):49-52

Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.

Ocular adnexal lymphoma may involve the eyelids, conjunctiva, orbital tissue, or lacrimal structures. The majority are non-Hodgkin's B-cell lymphomas of mucosa-associated lymphoid tissue (MALT) lymphoma type. Follicular lymphomas represent a small percentage of ocular adnexa lymphomas, particularly in Japan. We report a 68-year-old female patient who presented with a salmon pink patch-like lesion of the left conjunctiva, suspected of being (MALT) lymphoma. However, histologic and immunohistologic examinations were consistent with follicular lymphoma. This case demonstrates the importance of considering such rare lymphomas when making a diagnosis of ocular adnexal lymphoid neoplasms. [J Clin Exp Hematop 53(1): 49-52, 2013].
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http://dx.doi.org/10.3960/jslrt.53.49DOI Listing
May 2014

Pathological findings of infraorbital nerve enlargement in IgG4-related ophthalmic disease.

Jpn J Ophthalmol 2012 Sep 27;56(5):511-4. Epub 2012 Jul 27.

Department of Ophthalmology, Mitoyo General Hospital, 708 Himehama, Toyohama-cho, Kanonji, Kagawa 769-1695, Japan.

Purpose: We report a case of bilateral infraorbital nerve enlargement (IONE) associated with immunoglobulin (Ig)G4-related ophthalmic disease and describe the associated histopathologic findings.

Case: An otherwise healthy 59-year-old man presented with bilateral exophthalmos and right visual disturbance. Orbital magnetic resonance imaging showed bilateral IONE and a soft tissue mass in the right orbit. Excisional biopsy in the left infraorbital canal was performed. Histopathologic assessment revealed IgG4-related disease involving the epineurium of the infraorbital nerve. The patient received systemic steroid therapy, to which he responded well.

Conclusion: IONE in IgG4-related ophthalmic disease is due to IgG4-related disease involving the epineurium.
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http://dx.doi.org/10.1007/s10384-012-0170-3DOI Listing
September 2012

The usefulness of infraorbital nerve enlargement on MRI imaging in clinical diagnosis of IgG4-related orbital disease.

Jpn J Ophthalmol 2012 Jul 30;56(4):380-2. Epub 2012 May 30.

Section of Ophthalmology, National Hospital Organization Okayama Medical Center, 1711-1 Tamasu, Kitaku, Okayama 701-1154, Japan.

Purpose: To investigate the frequency of infraorbital nerve enlargement (IONE) in orbital lymphoproliferative disorders, and to show that IONE can contribute to the clinical diagnosis of IgG4-related orbital diseases (IgG4-ROD).

Subjects And Methods: 71 cases in which orbital lymphoproliferative disorders were diagnosed at Okayama Medical Center and Mitoyo General Hospital from April, 2004 to March, 2011 were investigated. The male-to-female ratio was 39:32, and the age range 27-87 years old (average age 64.1 years). Whenever the coronal section of the infraorbital nerve was larger than that of the optic nerve on MRI, it was defined as IONE.

Results: The breakdown of the 71 cases was: 45 cases of non-Hodgkin lymphoma, 16 cases of IgG4-ROD, 5 cases of reactive lymphoid hyperplasia, and 5 cases of idiopathic orbital inflammation. Of these, a total of 9 cases had IONE. The incidence of IONE was compared between the IgG4-ROD patient group and the non-IgG4-ROD patient group and was significantly higher in the IgG4-ROD patient group (p < 0.0001).

Conclusion: If IONE is observed in a case of orbital lymphoproliferative disorders on MRI, then it is highly possible that such a case is IgG4-ROD.
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http://dx.doi.org/10.1007/s10384-012-0151-6DOI Listing
July 2012
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