Publications by authors named "Yuji Yamanashi"

51Publications

DOK7 Gene Therapy Enhances Neuromuscular Junction Innervation and Motor Function in Aged Mice.

iScience 2020 Aug 5;23(8):101385. Epub 2020 Aug 5.

Division of Genetics, Department of Cancer Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Electronic address:

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August 2020

Effect of salbutamol on neuromuscular junction function and structure in a mouse model of DOK7 congenital myasthenia.

Hum Mol Genet 2020 Aug;29(14):2325-2336

Neurosciences Group, Nuffield Department of Clinical Neurosciences, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.

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August 2020

Overexpression of Dok-7 in skeletal muscle enhances neuromuscular transmission with structural alterations of neuromuscular junctions: Implications in robustness of neuromuscular transmission.

Biochem Biophys Res Commun 2020 02 14;523(1):214-219. Epub 2019 Dec 14.

Division of Genetics, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan. Electronic address:

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February 2020

Loss of C/EBPδ enhances apoptosis of intestinal epithelial cells and exacerbates experimental colitis in mice.

Genes Cells 2019 Sep 15;24(9):619-626. Epub 2019 Jul 15.

Division of Genetics, Department of Cancer Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

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September 2019

Dok-3 and Dok-1/-2 adaptors play distinctive roles in cell fusion and proliferation during osteoclastogenesis and cooperatively protect mice from osteopenia.

Biochem Biophys Res Commun 2018 04 17;498(4):967-974. Epub 2018 Mar 17.

Division of Genetics, The Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan. Electronic address:

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April 2018

[Homeostasis and Disorder of Musculoskeletal System.Molecular signaling and its pathogenic alterations in neuromuscular junction formation.]

Clin Calcium 2018;28(3):360-366

Division of Genetics, Department of Cancer Biology, the Institute of Medical Science, the University of Tokyo, Japan.

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February 2019

Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7.

Sci Rep 2017 08 4;7(1):7348. Epub 2017 Aug 4.

Department of Developmental and Regenerative Biology, Medical Research Institute, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.

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August 2017

gene therapy enhances motor activity and life span in ALS model mice.

EMBO Mol Med 2017 07;9(7):880-889

Division of Genetics, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

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July 2017

[Molecular mechanisms underlying the formation and maintenance of neuromuscular junctions and a possible therapeutic approach.]

Clin Calcium 2017;27(3):413-419

Division of Genetics, Department of Cancer Biology, The Institute of Medical Science, The University of Tokyo, Japan.

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October 2017

Loss of Dok-1 and Dok-2 in mice causes severe experimental colitis accompanied by reduced expression of IL-17A and IL-22.

Biochem Biophys Res Commun 2016 09 20;478(1):135-142. Epub 2016 Jul 20.

Division of Genetics, Department of Cancer Biology, The Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan. Electronic address:

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September 2016

Postnatal knockdown of dok-7 gene expression in mice causes structural defects in neuromuscular synapses and myasthenic pathology.

Genes Cells 2016 Jun 18;21(6):670-6. Epub 2016 Apr 18.

Division of Genetics, Department of Cancer Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan.

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June 2016

Human TUBG2 gene is expressed as two splice variant mRNA and involved in cell growth.

FEBS Lett 2016 04 6;590(8):1053-63. Epub 2016 Apr 6.

Department of Life Sciences Graduate School of Arts and Sciences, The University of Tokyo, Japan.

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April 2016

The MuSK activator agrin has a separate role essential for postnatal maintenance of neuromuscular synapses.

Proc Natl Acad Sci U S A 2014 Nov 3;111(46):16556-61. Epub 2014 Nov 3.

Division of Genetics, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan;

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November 2014

Critical role of Frizzled1 in age-related alterations of Wnt/β-catenin signal in myogenic cells during differentiation.

Genes Cells 2014 Apr 29;19(4):287-96. Epub 2014 Jan 29.

Department of Physiology and Cell Biology, Graduate School of Medicine, Kobe University, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.

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April 2014

Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin αIIbβ3 in mice.

J Biol Chem 2014 Feb 2;289(8):5051-60. Epub 2014 Jan 2.

From the Australian Centre for Blood Diseases, Faculty of Medicine, Nursing, and Health Sciences, Monash University, Alfred Medical Research and Education Precinct, Commercial Road, Melbourne, Victoria 3004.

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February 2014

Mesdc2 plays a key role in cell-surface expression of Lrp4 and postsynaptic specialization in myotubes.

FEBS Lett 2013 Nov 15;587(23):3749-54. Epub 2013 Oct 15.

Division of Genetics, Department of Cancer Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

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November 2013