Publications

CYP2C19 variants and epoxyeicosatrienoic acids in patients with microvascular angina.
Int J Cardiol Heart Vasc 2017 Jun 12;15:15-20. Epub 2017 Apr 12.
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

Relationship between asymptomatic intra-cranial lesions and brachial-ankle pulse wave velocity in coronary artery disease patients without stroke.
Hypertens Res 2017 Apr 24;40(4):392-398. Epub 2016 Nov 24.
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.





Unprotected left main intervention for surgery-ineligible patients with coronary artery disease-Usefulness of micro-CT images for stent.
Int J Cardiol 2016 Oct 5;221:385-9. Epub 2016 Jul 5.
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; X-Earth Center, Graduate School of Science and Technology, Kumamoto University, Kumamoto, Japan.

Changes in the risk factors for coronary spasm.
Int J Cardiol Heart Vasc 2016 Sep 5;12:85-87. Epub 2016 Aug 5.
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.






Clinical characteristics and intravascular ultrasound findings of culprit lesions in elderly patients with acute coronary syndrome.
Heart Vessels 2016 Mar 19;31(3):341-50. Epub 2014 Dec 19.
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.


Total Thrombus-Formation Analysis System (T-TAS) Can Predict Periprocedural Bleeding Events in Patients Undergoing Catheter Ablation for Atrial Fibrillation.
J Am Heart Assoc 2016 Jan 25;5(1). Epub 2016 Jan 25.
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan (M.I., K.K., D.S., M.I., Y.O., Y.A., S.I., A.T., T.H., H.K., K.S., E.Y., K.T., M.Y., S.K., S.H., H.Y., H.O.).


Determinants of Myocardial Lactate Production During Acetylcholine Provocation Test in Patients With Coronary Spasm.
J Am Heart Assoc 2015 Dec 11;4(12). Epub 2015 Dec 11.
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan (K.K., M.I., K.S., M.N., Y.A., T.T., K.S., K.S., Y.I., E.Y., K.T., M.Y., S.K., H.S., S.H., H.O.).



Distinct effects of Hoxa2 overexpression in cranial neural crest populations reveal that the mammalian hyomandibular-ceratohyal boundary maps within the styloid process.
Dev Biol 2015 Jun 16;402(2):162-74. Epub 2015 Apr 16.
Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Chiyoda-ku, Tokyo 102-0076, Japan; Institute for Biology and Mathematics of Dynamical Cell Processes (iBMath), The University of Tokyo, 3-8-1 Komaba, Tokyo 153-8914, Japan. Electronic address:






Gender differences in impact of CYP2C19 polymorphism on development of coronary artery disease.
J Cardiovasc Pharmacol 2015 Feb;65(2):148-52
*Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto City, Japan; and †Division of Pharmacology and Therapeutics, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto City, Japan.

Combined effects of current-smoking and the aldehyde dehydrogenase 2*2 allele on the risk of myocardial infarction in Japanese patients.
Toxicol Lett 2015 Jan 15;232(1):221-5. Epub 2014 Nov 15.
Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan; Center for Clinical Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan. Electronic address:




Impact of CYP2C19 polymorphism on clinical outcome following coronary stenting is more important in non-diabetic than diabetic patients.
Thromb Res 2014 Jul 26;134(1):72-7. Epub 2014 Apr 26.
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart.
Nat Commun 2014 Jul 29;5:4552. Epub 2014 Jul 29.
1] Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan [2] Core Research for Evolutional Science and Technology (CREST), Japan Science Technology Agency, 4-1-8, Honcho, Kawaguchi, Saitama 332-0012, Japan.


Endothelin regulates neural crest deployment and fate to form great vessels through Dlx5/Dlx6-independent mechanisms.
Mech Dev 2013 Nov-Dec;130(11-12):553-66. Epub 2013 Aug 8.
Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Preotic neural crest cells contribute to coronary artery smooth muscle involving endothelin signalling.
Nat Commun 2012 ;3:1267
Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Angiogenic morphogenesis driven by dynamic and heterogeneous collective endothelial cell movement.
Development 2011 Nov 28;138(21):4763-76. Epub 2011 Sep 28.
Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

OF