Publications by authors named "Yuhua Wang"

373 Publications

Path planning of scenic spots based on improved A* algorithm.

Sci Rep 2022 Jan 25;12(1):1320. Epub 2022 Jan 25.

State Key Laboratory of Cryospheric Science, Northwest Institute of Eco-Environment and Resources, Chinese Academy Sciences, Lanzhou, 730000, China.

Traditional scenic route planning only considers the shortest path, which ignores the information of scenic road conditions. As the most effective direct search method to solve the shortest path in static road network, A* algorithm can plan the optimal scenic route by comprehensively evaluating the weights of each expanded node in the gridded scenic area. However, A* algorithm has the problem of traversing more nodes and ignoring the cost of road in the route planning. In order to bring better travel experience to the travelers, the above factors are taken into account. This paper presents a path planning method based on the improved A* algorithm. Firstly, the heuristic function of the A* algorithm is weighted by exponential decay to improve the calculation efficiency of the algorithm. Secondly, in order to increase the practicality of the A* algorithm, the impact factors that road conditions is introduced to the evaluation function. Finally, the feasibility of the improved A* algorithm is verified through simulation experiments. Experimental results show that the improved A* algorithm can effectively reduce the calculation time and road cost.
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http://dx.doi.org/10.1038/s41598-022-05386-6DOI Listing
January 2022

Cold Response Transcriptome Analysis of the Alternative Splicing Events Induced by the Cold Stress in .

Int J Mol Sci 2022 Jan 17;23(2). Epub 2022 Jan 17.

The Germplasm Bank of Wild Species, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.

is a valuable medicinal herb and gardening plant due to its ornamental value and special medical value. Low temperature is a major bottleneck restricting expansion towards the north, which influences the quality and yield of . In this study, we analysed the cold response of by RNA-Seq. A total of 4302 differentially expressed genes were detected under cold stress, which were mainly linked to protein kinase activity, membrane transport and the glycan biosynthesis and metabolism pathway. We also identified 4005 differential alternative events in 2319 genes significantly regulated by cold stress. Exon skipping and intron retention were the most common alternative splicing isoforms. Numerous genes were identified that differentially modulated under cold stress, including cold-induced transcription factors and splicing factors mediated by AS (alternative splicing). GO enrichment analysis found that differentially alternatively spliced genes without differential expression levels were related to RNA/mRNA processing and spliceosomes. DAS (differentially alternative splicing) genes with different expression levels were mainly enriched in protein kinase activity, plasma membrane and cellular response to stimulus. We further identified and cloned in ; we found that promotes the generation of alternative splicing variants in cold-induced genes under cold stress via genetic experiments and RT-PCR. Taken together, our results identify the main cold-response pathways and alternative splicing events in responding to cold treatment and that of get involved in regulating the AS and gene expression of cold-induced genes during this process. Our study will contribute to understanding the role of AS genes in regulating the cold stress response in .
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http://dx.doi.org/10.3390/ijms23020981DOI Listing
January 2022

Rare Distribution of Sclerotic Bony Lesions in Multiple Myeloma: A Case Report.

Clin Nucl Med 2022 Jan 11. Epub 2022 Jan 11.

From the Department of Nuclear Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Abstract: A 66-year-old man was referred to our hospital due to a newly discovered left chest wall mass, which was diagnosed as plasmacytoma on biopsy. The patient underwent 18F-FDG PET/CT scanning before treatment. PET imaging revealed intense FDG signal in osseous lesions, and the CT showed most of the lesions were osteoblastic. The osseous lesions were predominantly localized to the humerus, femur, tibia, and phalanx of toe.
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http://dx.doi.org/10.1097/RLU.0000000000003967DOI Listing
January 2022

Titanium dioxide-mediated fatty acids promoted carotenoid synthesis in Phaffia rhodozyma PR106 analyzed whole genome.

Bioresour Technol 2022 Jan 10;347:126699. Epub 2022 Jan 10.

College of Food Science and Engineering, Jilin Agricultural University, Changchun, China; Jilin Province Innovation Center for Food Biological Manufacture, Jilin Agricultural University, Changchun, China; National Engineering Laboratory for Wheat and Corn Deep Processing, Changchun, China.

Carotenoid, as good colorant and antioxidant, is widely used in the fields of food, medicine and feed. The whole genome of P. rhodozyma PR106 strain with 228.77 mg/L carotenoid (mainly included astaxanthin, β-carotene and lycopene) yield was sequenced, and the genome size was 16.18 Mb, the GC content was 47%. The genetic evolution analysis indicated that PR106 greatly changed in evolution process, and closely related to P. rhodozyma CBS7918. Under 500 mg/L titanium dioxide (TiO) stress, carotenoid yield of PR106 was 2.15 times that of the control for 48 h, and was 305.12 mg/L in PR106 to 72 h, interestingly, the yield of oleate, linoleate and α-linolenate also increased significantly among 51 fatty acids by targeted metabolomics analysis. TiO promoted carotenoid synthesis of PR106 by forming astaxanthin esters to reduce the feedback inhibition of carotenoid synthesis. These results provided a theoretical basis for carotenoid production and development using P. rhodozyma.
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http://dx.doi.org/10.1016/j.biortech.2022.126699DOI Listing
January 2022

Fluorescent Carbon Dots an Effective Nano-Thermometer in Vitro Applications.

ACS Appl Bio Mater 2021 Jul 8;4(7):5786-5796. Epub 2021 Jul 8.

National and Local Joint Engineering Laboratory of Optical-Conversion Materials and Technology, School of Physical Science and Technology, Lanzhou University, Lanzhou 730000, P.R. China.

Fluorescent sensing of temperature in nanoscale regions has many advantages and applications in the biological field. Herein, blue emitting carbon dots (CDs) are designed and successfully developed using a one step hydrothermal method. As synthesized CDs exhibit temperature dependent photoluminescent (PL) intensity and PL decay lifetime over the physiological temperature ranging from room temperature (RT) to 70 °C. The PL intensity and PL decay lifetime of the obtained CDs correlate linearly to temperature (RT-70 °C) with correlation coefficient of 0.997 and 0.996, respectively. Additionally, dual mode thermal sensing (PL intensity/lifetime) make these CDs a promising optical nanothermometer over alternative semiconductors quantum dots and CD-based quantum dots. Moreover, the resultant aqueous CDs demonstrate excitation-independent blue emission, and the PL quantum yield (QY) is reached at 44.5%. The obtained CDs illustrate stable performance to high ionic environments and photobleaching even after keeping them for 2 h under continues UV irradiation. Furthermore, blue emitting CDs have low cytotoxicity for T-ca. cells and illuminate deep blue fluorescence under the excitation of 406 nm. As a result, high thermal sensitivity of these fluorescent CDs has potential to detect temperature in living cells in the range of 25-40 °C.
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http://dx.doi.org/10.1021/acsabm.1c00528DOI Listing
July 2021

In Situ Embedding Synthesis of [email protected]@SiO Nanocomposites for High Efficiency Light-Emitting Diodes: Suppressing Reabsorption Losses through the Waveguiding Effect.

ACS Appl Mater Interfaces 2022 Jan 4;14(2):3176-3188. Epub 2022 Jan 4.

Department of Materials Science, School of Physical Science and Technology, National and Local Joint Engineering Laboratory for Optical Conversion Materials and Technology of National Development and Reform Commission, Lanzhou University, Lanzhou 730000, China.

All-inorganic perovskite quantum dots (PQDs), which possess outstanding photophysical properties, are regarded as promising materials for optoelectronic applications. However, the poor light conversion efficiency and severe stability problem hinder their widespread applications. In this work, a novel encapsulation strategy is developed through the in situ growth of CsPbX PQDs in presynthesized mesoporous cerium-based metal organic frameworks (Ce-MOFs) and further silane hydrolysis-encapsulation, generating stable [email protected]@SiO composites with greatly enhanced light conversion efficiency. Moreover, the simulation results suggest that the pore boundary of Ce-MOFs has a strong waveguide effect on the incident PQD light, constraining PQD light inside the bodies of Ce-MOFs and suppressing reabsorption losses, thus increasing the overall light conversion efficiency of PQDs. Meanwhile, the [email protected] protective shell effectively improves the stability by blocking internally embedded PQDs from the harmful external environment. Further, the obtained white-light-emitting diode shows an ultrahigh luminous efficiency of 87.8 lm/W, which demonstrates their great potential in optoelectronic applications.
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http://dx.doi.org/10.1021/acsami.1c20804DOI Listing
January 2022

Ultrasonic pretreatment of spodumene with different size fractions and its influence on flotation.

Ultrason Sonochem 2021 Dec 28;82:105889. Epub 2021 Dec 28.

School of Minerals Processing and Bioengineering, Central South University, Changsha, China.

The potential of ultrasonic pretreatment enhancing selective surface dissolution to improve the floatability of spodumene with different size fractions was verified and investigated. For coarse particles of -0.15 + 0.0385 mm, compared with traditional pretreatment methods, ultrasonic pretreatment could optimize the physicochemical properties of the surface, markedly increased the amount of NaOL adsorbed on the mineral surface, and improved the floatability of the spodumene. For fine particles of -0.0385 mm, both pretreatment methods (Ultrasonic and Traditional) could greatly increase the flotation recovery, but ultrasonic pretreatment had no obvious advantage compared with traditional method. ICP combined with XPS analysis were conducted to investigate the dissolution mechanism of spodumene surface in different pretreatment system. Si species on the surface of coarse particles were easily dissolved into the solution under the effect of ultrasound, which increases the relative content of Al and Li species on the surface. This was conducive to the adsorption of the collectors on the surface. However, the selective dissolution of the fine particle surface was weakened by excessive energy intake in the ultrasonic system, which neutralized the advantage brought by the large amount of dissolution, making the results obtained by the two preprocessing methods the same.
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http://dx.doi.org/10.1016/j.ultsonch.2021.105889DOI Listing
December 2021

Characteristics of lipoxygenase-based and lipoxygenase-deficient soy yogurt with modified okara.

Food Sci Biotechnol 2021 Dec 26;30(13):1675-1684. Epub 2021 Nov 26.

College of Food Science and Engineering, Jilin Agricultural University, Changchun , 130118 Jilin Province China.

Lipoxygenase-based and lipoxygenase-deficient okara were modified by fermentation, then adding modified okara back to the corresponding soymilk to prepare soy yogurt. The physicochemical properties, texture, and volatile components of soy yogurt were characterized. The results showed that okara modified by fermentation was rich in soluable dietary fiber and was imparted better water-holding capacity, swelling capacity, and oil-holding capacity. The soy yogurt with the modified okara was greatly enhanced in its appearance, texture and was relatively stable during storage. Moreover, lipoxygenase-based soy yogurt had a unique soybean flavor while lipoxygenase-deficient soy yogurt had a slight beany flavor and soybean flavor. This article guides a bio-modified method for okara and provides a theoretical basis for the further development and application of soy yogurt with high dietary fiber as well as lipoxygenase-deficient soy yogurt.

Supplementary Information: The online version contains supplementary material available at 10.1007/s10068-021-01003-w.
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http://dx.doi.org/10.1007/s10068-021-01003-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639974PMC
December 2021

The performance of water-soluble fluoride transformation in soil-tea-tea infusion chain system and the potential health risk assessment.

J Sci Food Agric 2021 Nov 9. Epub 2021 Nov 9.

College of Horticulture, Nanjing Agricultural University, Nanjing, P. R. China.

Background: Water-soluble fluoride (WS-F) can be absorbed directly by tea plants from soil and comprises a major source of dietary F in tea consumers. To reveal the WS-F accumulation in tea leaves and assess WS-F health risks, 70 sets of samples including tea leaves at three maturity stages and corresponding topsoil were collected from Xinyang, China. The WS-F contents in tea samples and pH values in soil samples were determined.

Results: The contents of WS-F in tea leaves exhibited a positive correlation with leaf maturity. The contents of WS-F in tea leaves showed a positive correlation with WS-F contents in the soil as the soil pH value exceeds 5. All the bud with two leaves samples, 84.29% of the third to sixth leaves samples, and 78.57% mature leaves samples in 5-min infusion tend to be no health threat. The leaching characteristics of WS-F from tea leaves were influenced by the leaf maturity and soaking time.

Conclusion: Taking measures to control pH and WS-F concentration of plantations soil, as well as drinking tea infusion made from young leaves or reducing soaking time could decrease the WS-F health risk. © 2021 Society of Chemical Industry.
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http://dx.doi.org/10.1002/jsfa.11630DOI Listing
November 2021

Thioredoxin-1 mediates neuroprotection of Schisanhenol against MPP-induced apoptosis via suppression of ASK1-P38-NF-κB pathway in SH-SY5Y cells.

Sci Rep 2021 11 3;11(1):21604. Epub 2021 Nov 3.

Department of Pharmacy, Qiqihar Medical University, Qiqihar, China.

Oxidative stress-induced dopaminergic neuronal loss and apoptosis play a crucial role in the pathogenesis of Parkinson's disease (PD), and as a vital antioxidant protein, thioredoxin (Trx) exerts neuroprotection against PD. In this study, we investigated the effect of Schisanhenol (Sal), an active component from a traditional Chinese herb Schisandra rubriflora (Franch.), on MPP-induced apoptosis and its association with thioredoxin-1 (Trx1) in SH-SY5Y cells. The protein levels of Trx1 and apoptosis-related proteins were detected by Western blot, the expression of Trx1 mRNA by real time qPCR, and apoptosis was detected by fluorescence microscopy and flow cytometry. Pretreatment with Sal (1 µM, 10 µM, and 50 µM) dose-dependently ameliorated MPP-induced neuronal injury, confirmed by the improvement of the viability and morphological changes. Sal decreased the apoptosis rate of cells, suppressed the production of DNA ladder and sub-G1 peak, inhibited the Caspase-3 activity and the expression of apoptosis-related proteins. Sal enhanced the expression of Trx1 both in the protein and mRNA levels. However, the Trx1 inhibitor PX-12 suppressed the protective effects of Sal. In addition, Sal inhibited NF-κB translocation and activation. These results suggest that Sal has a protective effect against MPP-induced apoptosis in SH-SY5Y cells via up-regulation of Trx1 expression and suppression of ASK1-P38-NF-κB pathway.
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http://dx.doi.org/10.1038/s41598-021-01000-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566484PMC
November 2021

Matairesinol exerts anti-inflammatory and antioxidant effects in sepsis-mediated brain injury by repressing the MAPK and NF-κB pathways through up-regulating AMPK.

Aging (Albany NY) 2021 10 27;13(20):23780-23795. Epub 2021 Oct 27.

Rehabilitation Medicine Department, Shanxi Provincial People's Hospital, Taiyuan 030001, Shanxi, China.

Brain injury is a familiar complication of severe sepsis, in which excessive inflammation and oxidative stress are the main mechanisms leading to acute brain injury. Here, we focus on probing the function and mechanism of Matairesinol (Mat) in sepsis-mediated brain injury. We established a rat sepsis model by cecal ligation and perforation (CLP) and constructed an sepsis model by treating neurons and microglia with lipopolysaccharide (LPS). Rats and cells were treated with varying concentrations of Mat, and the changes of neural function, neuronal apoptosis, microglial activation, neuroinflammation and the expression of oxidative stress factors in brain tissues were examined. Additionally, the activation of the MAPK, NF-κB and AMPK pathways in brain tissues and cells was evaluated by Western blot (WB) and/or immunohistochemistry (IHC). Our findings illustrated that Mat improved neuronal apoptosis and weakened microglial activation in CLP rats. Meanwhile, Mat hampered the expression of pro-inflammatory factors (TNF-α, IL-1β, IL-6, IFN-γ, IL-8, and MCP1) and facilitated the contents of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) in brain tissues and microglia. Mechanistically, Mat concentration-dependently dampened the phosphorylation of MAPK, JNK and NF-κB in CLP rats and LPS-stimulated microglia and up-regulated Nrf2 and HO-1. Besides, Mat facilitated the AMPK expression. Meanwhile, Compound C, a specific inhibitor of the AMPK pathway, substantially reduced the neuronal protection and anti-inflammatory effects mediated by Mat. Overall, Mat exerts anti-inflammatory and anti-oxidative stress effects by up-regulating AMPK, thereby ameliorating sepsis-mediated brain injury.
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http://dx.doi.org/10.18632/aging.DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580336PMC
October 2021

Identification and response analysis of xyloglucan endotransglycosylase/hydrolases (XTH) family to fluoride and aluminum treatment in Camellia sinensis.

BMC Genomics 2021 Oct 25;22(1):761. Epub 2021 Oct 25.

College of Horticulture, Nanjing Agricultural University, Nanjing, 210095, China.

Background: Xyloglucan endotransglycosylase/hydrolases (XTH) can disrupt and reconnect the xyloglucan chains, modify the cellulose-xyloglucan complex structure in the cell wall to reconstruct the cell wall. Previous studies have reported that XTH plays a key role in the aluminum (Al) tolerance of tea plants (Camellia sinensis), which is a typical plant that accumulates Al and fluoride (F), but its role in F resistance has not been reported.

Results: Here, 14 CsXTH genes were identified from C. sinensis and named as CsXTH1-14. The phylogenetic analysis revealed that CsXTH members were divided into 3 subclasses, and conserved motif analysis showed that all these members included catalytic active region. Furthermore, the expressions of all CsXTH genes showed tissue-specific and were regulated by Al and F treatments. CsXTH1, CsXTH4, CsXTH6-8 and CsXTH11-14 were up-regulated under Al treatments; CsXTH1-10 and CsXTH12-14 responded to different concentrations of F treatments. The content of xyloglucan oligosaccharide determined by immunofluorescence labeling increased to the highest level at low concentrations of Al or F treatments (0.4 mM Al or 8 mg/L F), accompanying by the activity of XET (Xyloglucan endotransglucosylase) peaked.

Conclusion: In conclusion, CsXTH activities were regulated by Al or F via controlling the expressions of CsXTH genes and the content of xyloglucan oligosaccharide in C. sinensis roots was affected by Al or F, which might finally influence the elongation of roots and the growth of plants.
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http://dx.doi.org/10.1186/s12864-021-08056-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547062PMC
October 2021

Intranasal Administration of Polysaccharide Elicits Anti-Cancer Immunity against Lewis Lung Carcinoma.

Int J Mol Sci 2021 Sep 30;22(19). Epub 2021 Sep 30.

Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, Korea.

Natural polysaccharides have shown promising effects on the regulation of immunity in animals. In this study, we examined the immune stimulatory effect of intranasally administered polysaccharides (CFPs) in mice. Intranasal administration of CFPs in C57BL/6 mice induced the upregulation of surface activation marker expression in macrophages and dendritic cells (DCs) in the mediastinal lymph node (mLN) and the production of interleukin-6 (IL-6), IL-12p70, and tumor necrosis factor-α in bronchoalveolar lavage fluid. Moreover, the number of conventional DCs (cDCs) was increased in the mLNs by the upregulation of C-C motif chemokine receptor 7 expression, and subsets of cDCs were also activated following the intranasal administration of CFP. In addition, the intranasal administration of CFPs promoted the activation of natural killer (NK) and T cells in the mLNs, which produce pro-inflammatory cytokines and cytotoxic mediators. Finally, daily administration of CFPs inhibited the infiltration of Lewis lung carcinoma cells into the lungs, and the preventive effect of CFPs on tumor growth required NK and CD8 T cells. Furthermore, CFPs combined with anti-programmed cell death-ligand 1 (PD-L1) antibody (Ab) improved the therapeutic effect of anti-PD-L1 Ab against lung cancer. Therefore, these data demonstrated that the intranasal administration of CFP induced mucosal immunity against lung cancer.
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http://dx.doi.org/10.3390/ijms221910608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508762PMC
September 2021

Genome-Wide Analysis of the Transcription Factor Genes in Lindl.

Int J Mol Sci 2021 Sep 24;22(19). Epub 2021 Sep 24.

The Germplasm Bank of Wild Species, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.

Teosinte branched1/cycloidea/proliferating cell factor () gene family members are plant-specific transcription factors that regulate plant growth and development by controlling cell proliferation and differentiation. However, there are no reported studies on the gene family in Lindl. Here, a genome-wide analysis of genes was performed in , and 25 genes were identified. A phylogenetic analysis classified the family into two clades: Class I and Class II. Genes in the same clade share similar conserved motifs. The GFP signals of the DcaTCP-GFPs were detected in the nuclei of tobacco leaf epidermal cells. The activity of , which contains the miR319a-binding sequence, was reduced when combined with miR319a. A transient activity assay revealed antagonistic functions of Class I and Class II of the TCP proteins in controlling leaf development through the jasmonate-signaling pathway. After different phytohormone treatments, the genes showed varied expression patterns. In particular, and showed opposite trends after 3 h treatment with jasmonate. This comprehensive analysis provides a foundation for further studies on the roles of genes in .
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http://dx.doi.org/10.3390/ijms221910269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508941PMC
September 2021

Astaxanthin overproduction of Phaffia rhodozyma PR106 under titanium dioxide stress by transcriptomics and metabolic regulation analysis.

Bioresour Technol 2021 Dec 15;342:125957. Epub 2021 Sep 15.

College of Food Science and Engineering, Jilin Agricultural University, Changchun, China; Jilin Province Innovation Center for Food Biological Manufacture, Jilin Agricultural University, Changchun, China; National Engineering Laboratory for Wheat and Corn Deep Processing, Changchun, China. Electronic address:

In this study, astaxanthin yield of Phaffia rhodozyma PR106 increased significantly under titanium dioxide (TiO) stress, and the yield of lycopene and β-carotene also increased significantly, as well as the yield of violaxanthin and lutein significantly decreased; in addition, TiO stress promoted cell division and changed cell morphology of PR106. Then, the mechanism of increasing astaxanthin yield was studied by transcriptomics and related metabolic regulation. The results showed that astaxanthin accumulation in PR106 was not directly related to mRNA transcription and post-translational modifications regulation under TiO stress; TiO stress accelerated glucose uptake of yeast, promoted reuse of ethanol, and increased the formation of acetyl-CoA and ATP. The more carbon flux was shifted to astaxanthin synthesis pathway and weakened carotenoids accumulation in astaxanthin branch pathway to improve the astaxanthin production of PR106. The metabolism regulation of ROS could continue in the PR106 strain.
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http://dx.doi.org/10.1016/j.biortech.2021.125957DOI Listing
December 2021

Altered Functional Connectivity Strength at Rest in Medication-Free Obsessive-Compulsive Disorder.

Neural Plast 2021 8;2021:3741104. Epub 2021 Sep 8.

Department of Psychiatry, Qiqihar Medical University, Qiqihar, China.

Background: Previous studies explored the whole-brain functional connectome using the degree approach in patients with obsessive-compulsive disorder (OCD). However, whether the altered degree values can be used to discriminate OCD from healthy controls (HCs) remains unclear.

Methods: A total of 40 medication-free patients with OCD and 38 HCs underwent a resting-state functional magnetic resonance imaging (rs-fMRI) scan. Data were analyzed with the degree approach and a support vector machine (SVM) classifier.

Results: Patients with OCD showed increased degree values in the left thalamus and left cerebellum Crus I and decreased degree values in the left dorsolateral prefrontal cortex, right precuneus, and left postcentral gyrus. SVM classification analysis indicated that the increased degree value in the left thalamus is a marker of OCD, with an acceptable accuracy of 88.46%, sensitivity of 87.50%, and specificity of 89.47%.

Conclusion: Altered degree values within and outside the cortical-striatal-thalamic-cortical (CSTC) circuit may cocontribute to the pathophysiology of OCD. Increased degree values of the left thalamus can be used as a future marker for OCD understanding-classification.
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http://dx.doi.org/10.1155/2021/3741104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443365PMC
September 2021

RNA mA Modification Plays a Key Role in Maintaining Stem Cell Function in Normal and Malignant Hematopoiesis.

Front Cell Dev Biol 2021 13;9:710964. Epub 2021 Aug 13.

The State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.

N-methyladenosine (mA) is a commonly modification of mammalian mRNAs and plays key roles in various cellular processes. Emerging evidence reveals the importance of RNA mA modification in maintaining stem cell function in normal hematopoiesis and leukemogenesis. In this review, we first briefly summarize the latest advances in RNA mA biology, and further highlight the roles of mA writers, readers and erasers in normal hematopoiesis and acute myeloid leukemia. Moreover, we also discuss the mechanisms of these mA modifiers in preserving the function of hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs), as well as potential strategies for targeting mA modification related pathways. Overall, we provide a comprehensive summary and our insights into the field of RNA mA in normal hematopoiesis and leukemia pathogenesis.
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http://dx.doi.org/10.3389/fcell.2021.710964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8414639PMC
August 2021

Design of highly efficient deep-red emission in the Mn doped new-type structure CaMgAlO for plant growth LED light.

Dalton Trans 2021 Sep 9;50(34):11793-11803. Epub 2021 Aug 9.

National & Local Joint Engineering Laboratory for Optical Conversion Materials and Technology; School of Physical Science and Technology, Lanzhou University, No. 222, South Tianshui Road, Lanzhou, Gansu 730000, P. R. China.

The auxiliary light equipment for plant growth requires phosphor-converted light-emitting-diodes (pc-LEDs) with high luminous efficiency and a stable structure, and the properties of phosphors highly determine the performance of the pc-LEDs. This work reports a deep-red emitting phosphor with an ultra-wide response range which is regarded as CaMgAlO:Mn. The absorption range spans the ultraviolet, near-ultraviolet, blue, and green light regions from 250 to 550 nm. Under the excitation of the best excitation position at 343 nm, deep-red light at 654 nm is emitted, and the quantum efficiency is as high as 86.7%. The luminous efficiency of the two pc-LED devices prepared based on CaMgAlO:Mn with 395 and 460 nm chips reached 54.3 and 59.6 lm W, respectively. The spectra of the two pc-LEDs exhibit high resemblance to the absorption spectra of chlorophyll A and B in plant growth photosynthesis. These indicate that the CaMgAlO:Mn phosphor can be an excellent candidate for plant growth LED light.
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http://dx.doi.org/10.1039/d1dt02088aDOI Listing
September 2021

Functional Relationship of Arabidopsis AOXs and PTOX Revealed via Transgenic Analysis.

Front Plant Sci 2021 2;12:692847. Epub 2021 Jul 2.

Chinese Education Ministry's Key Laboratory of Western Resources and Modern Biotechnology, Key Laboratory of Biotechnology Shaanxi Province, College of Life Sciences, Northwest University, Xi'an, China.

Alternative oxidase (AOX) and plastid terminal oxidase (PTOX) are terminal oxidases of electron transfer in mitochondria and chloroplasts, respectively. Here, taking advantage of the variegation phenotype of the Arabidopsis PTOX deficient mutant (), we examined the functional relationship between PTOX and its five distantly related homologs (AOX1a, 1b, 1c, 1d, and AOX2). When engineered into chloroplasts, AOX1b, 1c, 1d, and AOX2 rescued the defect, while AOX1a partially suppressed the mutant phenotype, indicating that AOXs could function as PQH oxidases. When the full length AOXs were overexpressed in , only AOX1b and AOX2 rescued its variegation phenotype. fluorescence analysis of GFP-tagged AOXs and subcellular fractionation assays showed that AOX1b and AOX2 could partially enter chloroplasts while AOX1c and AOX1d were exclusively present in mitochondria. Surprisingly, the subcellular fractionation, but not the fluorescence analysis of GFP-tagged AOX1a, revealed that a small portion of AOX1a could sort into chloroplasts. We further fused and expressed the targeting peptides of AOXs with the mature form of PTOX in individually; and found that targeting peptides of AOX1a, AOX1b, and AOX2, but not that of AOX1c or AOX1d, could direct PTOX into chloroplasts. It demonstrated that chloroplast-localized AOXs, but not mitochondria-localized AOXs, can functionally compensate for the PTOX deficiency in chloroplasts, providing a direct evidence for the functional relevance of AOX and PTOX, shedding light on the interaction between mitochondria and chloroplasts and the complex mechanisms of protein dual targeting in plant cells.
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http://dx.doi.org/10.3389/fpls.2021.692847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336870PMC
July 2021

Identification of interacting proteins of Arabidopsis cyclophilin38 (AtCYP38) via multiple screening approaches reveals its possible broad functions in chloroplasts.

J Plant Physiol 2021 Sep 30;264:153487. Epub 2021 Jul 30.

Chinese Education Ministry's Key Laboratory of Western Resources and Modern Biotechnology, Key Laboratory of Biotechnology Shaanxi Province, College of Life Sciences, Northwest University, China P.R.229 North Taibai Road, Xi'an, Shaanxi, 710069, China. Electronic address:

AtCYP38, a thylakoid lumen localized immunophilin, is found to be essential for photosystem II assembly and maintenance, but how AtCYP38 functions in chloroplast remains unknown. Based on previous functional studies and its crystal structure, we hypothesize that AtCYP38 should function via binding its targets or cofactors in the thylakoid lumen. To identify potential interacting proteins of AtCYP38, we first adopted ATTED-II and STRING web-tools, and found 12 proteins functionally related to AtCYP38. We then screened a yeast two-hybrid library including an Arabidopsis genome wide cDNA with different domain of AtCYP38, and five thylakoid lumen-localized targets were identified. In order to specifically search interacting proteins of AtCYP38 in the thylakoid lumen, we generated a yeast two-hybrid mini library including the thylakoid lumenal proteins and lumenal fractions of thylakoid membrane proteins, and we obtained six thylakoid membrane proteins and nine thylakoid lumenal proteins as interacting proteins of AtCYP38. The interactions between AtCYP38 and several potential targets were further confirmed via pull-down and co-immunoprecipitation assays. Together, a couple of new potential candidate interacting proteins of AtCYP38 were identified, and the results will lay a foundation for unveiling the regulatory mechanisms in photosynthesis by AtCYP38.
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http://dx.doi.org/10.1016/j.jplph.2021.153487DOI Listing
September 2021

Relationship of soil pH value and soil Pb bio-availability and Pb enrichment in tea leaves.

J Sci Food Agric 2022 Feb 13;102(3):1137-1145. Epub 2021 Aug 13.

Key Laboratory of Agroecological Processing and Safety Monitoring, Fujian Province, Fujian Agriculture and Forestry University, Fuzhou, China.

Background: Lead (Pb) is not an essential element for the growth of tea trees, but it is an important index for evaluating the quality and safety of tea. Lead is a sensitive metal to pH. Exploring the changing trend of soil Pb and enrichment coefficient of Pb in tea leaves affected by soil acidification is significant for tea planting and tea quality safety control.

Results: A percent of 37.57% of the 364 tea plantations in Anxi county of China showed soil acidification that is a soil pH value < 4.5. However, the total Pb content in the soil and Pb content of tea leaves met the requirements stipulated in China. The soil available Pb content and Pb content in tea leaves were both significantly negatively correlated with soil pH value, and increased with the decrease of soil pH value. The soil available Pb content had a significant positive correlation with soil total Pb content. However, the soil total Pb content had no significant correlation with soil pH value. Moreover, the soil Pb bio-availability coefficient and the Pb enrichment coefficient of tea leaves decreased with the increase of soil pH value.

Conclusion: More than a third of tea plantations in Anxi county had been acidified. The decrease of pH value leads to an increase in the bio-availability coefficient of soil Pb content and the enrichment coefficient of Pb content in tea leaves. The lower soil pH value resulted in the increase of the absorption and accumulation of Pb by tea trees, thus an increase of Pb content in tea leaves. © 2021 Society of Chemical Industry.
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http://dx.doi.org/10.1002/jsfa.11450DOI Listing
February 2022

Association of DYNC1H1 gene SNP/CNV with disease susceptibility, GCs efficacy, HRQOL, anxiety, and depression in Chinese SLE patients.

J Clin Lab Anal 2021 Aug 17;35(8):e23892. Epub 2021 Jul 17.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.

Background: Systemic lupus erythematosus is a heterogeneous autoimmune disease characterized by multi-system injuries and overproduction of autoantibodies. There are many genetic studies on SLE, but no report has considered the relationship between cytoplasmic dynein and SLE susceptibility.

Objectives: Our study intends to investigate whether DYNC1H1 gene SNP/CNV is related to SLE susceptibility, GCs efficacy, HRQOL, anxiety, and depression in Chinese SLE patients.

Methods: A total of 502 cases and 544 healthy controls were recruited into the case-control study, and 472 subjects from the case group were followed up for 12 weeks to evaluate GCs efficacy, HRQOL, anxiety, and depression. Multiplex SNaPshot technique was applied to genotype the seven SNPs of DYNC1H1, and AccuCopy method was conducted to quantify the copy number of DYNC1H1. Anxiety and depression were evaluated using HAMA and HAMD-24 scales, respectively. The SF-36 scale was used to assess HRQOL.

Results: The significant association between SNP rs1190606 and SLE susceptibility was displayed in the dominant model (P = 0.004) as well as its allele model (P = 0.004). We also found that SNP rs2273440 was related to photosensitization symptom in SLE patients (P = 0.032). In the follow-up study, SNP rs11160668 was connected with the improvement of BP in male patients (P = 0.011). However, no association of DYNC1H1 gene with GCs efficacy, anxiety, and depression was found. No CNV in DYNC1H1 was detected.

Conclusions: The study suggests that DYNC1H1 gene polymorphisms may have an effect on SLE susceptibility and BP improvement of HRQOL in Chinese SLE patients.
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http://dx.doi.org/10.1002/jcla.23892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373356PMC
August 2021

MicroRNA Omics Analysis of Pollen Tubes in Response to Low-Temperature and Nitric Oxide.

Biomolecules 2021 06 23;11(7). Epub 2021 Jun 23.

College of Horticulture, Nanjing Agricultural University, Nanjing 210095, China.

Nitric oxide (NO) as a momentous signal molecule participates in plant reproductive development and responds to various abiotic stresses. Here, the inhibitory effects of the NO-dominated signal network on the pollen tube growth of under low temperature (LT) were studied by microRNA (miRNA) omics analysis. The results showed that 77 and 71 differentially expressed miRNAs (DEMs) were induced by LT and NO treatment, respectively. Gene ontology (GO) analysis showed that DEM target genes related to microtubules and actin were enriched uniquely under LT treatment, while DEM target genes related to redox process were enriched uniquely under NO treatment. In addition, the target genes of miRNA co-regulated by LT and NO are only located on the cell membrane and cell wall, and most of them are enriched in metal ion binding and/or transport and cell wall organization. Furthermore, DEM and its target genes related to metal ion binding/transport, redox process, actin, cell wall organization and carbohydrate metabolism were identified and quantified by functional analysis and qRT-PCR. In conclusion, miRNA omics analysis provides a complex signal network regulated by NO-mediated miRNA, which changes cell structure and component distribution by adjusting Ca gradient, thus affecting the polar growth of the pollen tube tip under LT.
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http://dx.doi.org/10.3390/biom11070930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301950PMC
June 2021

Disrupted Asymmetry of Inter- and Intra-Hemispheric Functional Connectivity at Rest in Medication-Free Obsessive-Compulsive Disorder.

Front Neurosci 2021 9;15:634557. Epub 2021 Jun 9.

Department of Psychiatry, Qiqihar Medical University, Qiqihar, China.

Disrupted functional asymmetry of cerebral hemispheres may be altered in patients with obsessive-compulsive disorder (OCD). However, little is known about whether anomalous brain asymmetries originate from inter- and/or intra-hemispheric functional connectivity (FC) at rest in OCD. In this study, resting-state functional magnetic resonance imaging was applied to 40 medication-free patients with OCD and 38 gender-, age-, and education-matched healthy controls (HCs). Data were analyzed using the parameter of asymmetry (PAS) and support vector machine methods. Patients with OCD showed significantly increased PAS in the left posterior cingulate cortex, left precentral gyrus/postcentral gyrus, and right inferior occipital gyrus and decreased PAS in the left dorsolateral prefrontal cortex (DLPFC), bilateral middle cingulate cortex (MCC), left inferior parietal lobule, and left cerebellum Crus I. A negative correlation was found between decreased PAS in the left DLPFC and Yale-Brown Obsessive-compulsive Scale compulsive behavior scores in the patients. Furthermore, decreased PAS in the bilateral MCC could be used to distinguish OCD from HCs with a sensitivity of 87.50%, an accuracy of 88.46%, and a specificity of 89.47%. These results highlighted the contribution of disrupted asymmetry of intra-hemispheric FC within and outside the cortico-striato-thalamocortical circuits at rest in the pathophysiology of OCD, and reduced intra-hemispheric FC in the bilateral MCC may serve as a potential biomarker to classify individuals with OCD from HCs.
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http://dx.doi.org/10.3389/fnins.2021.634557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220135PMC
June 2021

Decreased Nucleus Accumbens Connectivity at Rest in Medication-Free Patients with Obsessive-Compulsive Disorder.

Neural Plast 2021 1;2021:9966378. Epub 2021 Jun 1.

Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China.

Background: Patients with obsessive-compulsive disorder (OCD) experience deficiencies in reward processing. The investigation of the reward circuit and its essential connectivity may further clarify the pathogenesis of OCD.

Methods: The current research was designed to analyze the nucleus accumbens (NAc) functional connectivity at rest in medicine-free patients with OCD. Forty medication-free patients and 38 gender-, education-, and age-matched healthy controls (HCs) were recruited for resting-state functional magnetic resonance imaging. Seed-based functional connectivity (FC) was used to analyze the data. LIBSVM (library for support vector machines) was designed to identify whether altered FC could be applied to differentiate OCD.

Results: Patients with OCD showed remarkably decreased FC values between the left NAc and the bilateral orbitofrontal cortex (OFC) and bilateral medial prefrontal cortex (MPFC) and between the right NAc and the left OFC at rest in the reward circuit. Moreover, decreased left NAc-bilateral MPFC connectivity can be deemed as a potential biomarker to differentiate OCD from HCs with a sensitivity of 80.00% and a specificity of 76.32%.

Conclusion: The current results emphasize the importance of the reward circuit in the pathogenesis of OCD.
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http://dx.doi.org/10.1155/2021/9966378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187042PMC
January 2022

PP04 improves high-fat diet-induced liver injury by the modulation of gut inflammation and intestinal microbiota in C57BL/6N mice.

Food Funct 2021 Aug;12(15):6851-6862

College of Food Science and Engineering, Jilin Agricultural University, Changchun, China.

In this study, Pediococcus pentococcus PP04 (PP04) isolated from the Northeast pickled cabbage was given to C57BL/6N mice for eight weeks, aiming to investigate the ameliorative effects of PP04 on liver injury induced by a high-fat diet. The western blot results suggested that PP04 ameliorated the increase of intestinal permeability by dramatically increasing the expressions of tight junction proteins, such as Occludin, Claudin-1 and ZO-1, which decreased hepatic lipopolysaccharides (LPS), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) concentrations to effectively alleviate the liver injury. Furthermore, PP04 relieved the high-fat diet-caused gut inflammation by the NF-κB/Nrf2 signaling pathway, which regulated the expression of inflammatory cytokines and antioxidants, to positively improve the liver injury. In addition, the 16S rDNA sequencing results inferred that PP04 had the potential to rebalance intestinal flora disorders through regulating the relative abundance of inflammation and obesity-related bacteria in mice.
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http://dx.doi.org/10.1039/d1fo00857aDOI Listing
August 2021

Nanoparticle Delivery of STAT3 Alleviates Pulmonary Hypertension in a Mouse Model of Alveolar Capillary Dysplasia.

Circulation 2021 08 11;144(7):539-555. Epub 2021 Jun 11.

Center for Lung Regenerative Medicine, Perinatal Institute (F.S., G.W., A.P., K.X., J.G.-A., Y.Z., G.T.K., Z.D., A.W.D., V.V.K.), Cincinnati Children's Hospital Medical Center, OH.

Background: Pulmonary hypertension (PH) is a common complication in patients with alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV), a severe congenital disorder associated with mutations in the gene. Although the loss of alveolar microvasculature causes PH in patients with ACDMPV, it is unknown whether increasing neonatal lung angiogenesis could prevent PH and right ventricular (RV) hypertrophy.

Methods: We used echocardiography, RV catheterization, immunostaining, and biochemical methods to examine lung and heart remodeling and RV output in mice carrying the mutation (identified in patients with ACDMPV). The ability of mutant embryonic stem cells to differentiate into respiratory cell lineages in vivo was examined using blastocyst complementation. Intravascular delivery of nanoparticles with a nonintegrating expression vector was used to improve neonatal pulmonary angiogenesis in mice and determine its effects on PH and RV hypertrophy.

Results: mice developed PH and RV hypertrophy after birth. The severity of PH in mice directly correlated with mortality, low body weight, pulmonary artery muscularization, and increased collagen deposition in the lung tissue. Increased fibrotic remodeling was found in human ACDMPV lungs. Mouse embryonic stem cells carrying the mutation were used to produce chimeras through blastocyst complementation and to demonstrate that embryonic stem cells have a propensity to differentiate into pulmonary myofibroblasts. Intravascular delivery of nanoparticles carrying cDNA protected mice from RV hypertrophy and PH, improved survival, and decreased fibrotic lung remodeling.

Conclusions: Nanoparticle therapies increasing neonatal pulmonary angiogenesis may be considered to prevent PH in ACDMPV.
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http://dx.doi.org/10.1161/CIRCULATIONAHA.121.053980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373823PMC
August 2021

Cyan Broad-Band Emission Phosphor with Scandium Silicon Multiple-Ring Structure for White Light-Emitting Diodes and Field Emission Displays.

Inorg Chem 2021 Jun 7;60(12):8870-8879. Epub 2021 Jun 7.

Department of Materials Science, School of Physical Science and Technology, Key Laboratory of Special Function Materials and Structure Design of Ministry of Education, National and Local Joint Engineering Laboratory for Optical Conversion Materials and Technology of National Development and Reform Commission, Lanzhou University, Lanzhou 730000, P. R. China.

Silicate phosphor KBaScSiO:Ce (KBSS:Ce), as a novel material, has been prepared by the solid-state method in this study. The crystal structure, luminescent properties, thermal stability, and cathodoluminescence (CL) properties of this material were analyzed systematically. It concludes that the phosphor can emit cyan light with emission peak at 509 nm under n-UV light excitation (300-400 nm). By coating KBSS:Ce with a red-emitting CaAlSiN:Eu on a n-UV (365 nm) light-emitting diode (LED) chip, the intense warm white light with high (83.4) and low CCT (3652) can be produced under a 350 mA forward bias current.In addition, the CL performance shows that KBSS:0.10Ce has high saturation current and voltage and good color stability under low voltage conditions. All these results indicate that KBSS:Ce phosphor will be very promising in LED and field emission display applications.
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http://dx.doi.org/10.1021/acs.inorgchem.1c00773DOI Listing
June 2021

Sauchinone Blocks Ethanol Withdrawal-Induced Anxiety but Spares Locomotor Sensitization: Involvement of Nitric Oxide in the Bed Nucleus of the Stria Terminalis.

Evid Based Complement Alternat Med 2021 4;2021:6670212. Epub 2021 May 4.

Department of Psychopharmacology, Qiqihar Medical University, Qiqihar 161006, China.

Both the positive (manifested by locomotor sensitization) and negative (withdrawal symptoms) reinforcing effects of ethanol (EtOH) involve central nitric oxide (NO) signaling. Sauchinone (a bioactive lignan in ) has been shown to improve methamphetamine-induced behavioral and neurochemical changes via the NO signaling pathway. Thus, this study evaluated the effects of sauchinone on locomotor sensitization and anxiety during EtOH withdrawal (EtOHW). Male adult Sprague-Dawley rats were treated with 1.5 g/kg/day of EtOH (20%, vol/vol) via intraperitoneal injection for 28 days, followed by a 3-day withdrawal. During withdrawal, the rats were given intragastric sauchinone (2.5, 7.5, or 25 mg/kg/day) once a day. EtOH locomotor sensitization was determined by challenging EtOHW rats with 0.75 g/kg EtOH, while EtOHW-induced anxiety was assessed using the elevated plus maze (EPM). None of the three doses of sauchinone affected EtOH locomotor sensitization. However, in the EPM, treatment of EtOHW rats with sauchinone at 7.5 or 25 mg/kg/day increased both the number of entries into and the time spent in the open arms. Moreover, the two doses of sauchinone inhibited the oversecretion of plasma corticosterone during EtOHW. In the bed nucleus of the stria terminalis (BNST), EtOHW increased NO production, enhanced gene and protein expression of both inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS), and also elevated protein levels of corticotropin-releasing factor, which were all inhibited by 25 mg/kg/day sauchinone. In an in vitro experiment, sauchinone (3, 10, and 30 M) inhibited HO-stimulated nNOS protein expression in neuronal PC12 cells. Finally, intra-BNST infusion of sodium nitroprusside, a NO donor, after sauchinone (25 mg/kg/day) administration, abolished its expected anxiolytic effect. Taken together, these results indicate that sauchinone attenuates anxiety-like behavior in rats during EtOHW but spares EtOH locomotor sensitization, and the anxiolytic effect is mediated via the NO signaling pathway in the BNST.
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http://dx.doi.org/10.1155/2021/6670212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116157PMC
May 2021

Research Advances on Human-Eye-Sensitive Long Persistent Luminescence Materials.

Front Chem 2021 7;9:654347. Epub 2021 May 7.

Key Laboratory for Special Function Materials and Structure Design of the Ministry of Education, Lanzhou University, Lanzhou, China.

Based on the actual application requirements of multicolor long persistent luminescence (LPL) materials, we highlight the recent developments in the last decade on human-eye-sensitive LPL materials and try to make a full list of known LPL compounds possessing wavelengths of 400-600 nm and a duration time longer than 10 h (>0.32 mcd/m); these are more sensitive to the human eye's night vision and can be used throughout the night. We further emphasize our group research of novel LPL materials and the regulation of LPL color to enable a full palette. In the end, we try to summarize the challenges and perspectives of LPL materials for potential research directions based on our limited understandings. This review could offer new enlightenment for further exploration of new LPL materials in the visible light range and related applications.
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http://dx.doi.org/10.3389/fchem.2021.654347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138154PMC
May 2021
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