Publications by authors named "Yufeng Li"

414 Publications

Pancreatic Ductal Adenocarcinoma: Interface Enhancement Gradient Measured on Dual-Energy CT Images Improves Prognostic Evaluation.

Radiol Imaging Cancer 2020 Jul 17;2(4):e190074. Epub 2020 Jul 17.

Departments of Radiology (A.M.A., D.S., C.M.B., M.M.M., A.D.S., D.E.M.) and Biostatistics (Y.L.), University of Alabama at Birmingham, 619 19th St S, JTN 338, Birmingham, AL 35294-2172.

Purpose: To investigate the prognostic value of differential enhancement on baseline dual-energy CT images in patients with treatment-naive pancreatic ductal adenocarcinoma (PDAC), with a focus on tumor-host interface characterization.

Materials And Methods: This was a retrospective, institutional review board-approved, Health Insurance Portability and Accountability Act-compliant study of 158 consecutive adult patients (mean age, 68 years; age range, 40.9-88.9 years; 50% women) with histopathologically proven, treatment-naive PDAC, who had undergone multiphasic pancreatic dual-energy CT from December 2011 to March 2017. Regions of interest in tumor core, tumor border, pancreas border with tumor, nontumoral pancreas, and aorta were recorded on pancreatic parenchymal phase (PPP) dual-energy CT 70-keV, 52-keV, and iodine material density (MD) images, plus portal venous phase (PVP) conventional CT images. Enhancement gradient (delta) across the tumor-pancreas interface was calculated. Delta was evaluated combining the dual-energy CT values with the PVP values and as individual predictors. Receiver operating characteristic analysis with logistic regression was used to determine the optimal cut point for each dual-energy CT delta to predict disease outcome based on highest Youden index. Survival curves were generated using Kaplan-Meier method, and comparison between two independent groups (high and low delta) was evaluated with log-rank test. Clinical outcomes included overall survival and distant metastasis-free survival. Three independent blinded radiologists visually scored tumor conspicuity (subjective delta score) on a 1-5 scale, and agreement was evaluated with κ statistic.

Results: Ninety-three patients had advanced stage (50 locally advanced and 43 metastatic) and 65 had lower stage (48 resectable and 17 borderline resectable) tumors. Patients with high delta tumors (≥ 40 HU) on either 70-keV PPP images or conventional PVP images had significantly shorter overall survival compared with those with low delta tumors (< 40 HU) in both early stage PDAC (13.5 months vs 23.3 months; hazard ratio [HR], 1.87; 95% confidence interval [CI]: 1.01, 3.5; = .04) and advanced stage PDAC (10.8 months vs 18.0 months; HR, 2.1; 95% CI: 1.28, 3.6; = .003). Qualitative visual scoring of tumor conspicuity also showed shorter overall survival in patients with more conspicuous tumors. Highest interreader agreement for subjective delta score was 0.73 and 0.60 using iodine MD and 52-keV images, respectively.

Conclusion: Increased quantitative and qualitative border conspicuity (high delta) is associated with shorter survival in patients with PDAC. Agreement on the subjective qualitative characterization of PDAC borders is best achieved using iodine MD and lower-energy simulated monoenergetic images at pancreatic protocol dual-energy CT. Abdomen/GI, CT, CT-Dual Energy, CT-Quantitative, Pancreas© RSNA, 2020.
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http://dx.doi.org/10.1148/rycan.2020190074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983668PMC
July 2020

Cost-effectiveness of offering cervical cancer screening with HPV self-sampling among African-American women in the Mississippi Delta.

Cancer Epidemiol Biomarkers Prev 2021 Mar 26. Epub 2021 Mar 26.

Center for Health Decision Science, Department of Health Policy and Management, Harvard T.H. Chan School of Public Health.

Background: African-American women in the United States have an elevated risk of cervical cancer incidence and mortality. In the Mississippi Delta, cervical cancer disparities are particularly stark.

Methods: We conducted a micro-costing study alongside a group randomized trial that evaluated the efficacy of a patient-centered approach ('Choice' between self-collection at home for HPV testing or current standard of care within the public health system in Mississippi) versus the current standard of care ('Standard of care screening', involving cytology (i.e., Pap) and HPV co-testing at the Health Department clinics). The interventions in both study arms were delivered by community health workers (CHWs). Using cost, screening uptake, and colposcopy adherence data from the trial, we informed a mathematical model of HPV infection and cervical carcinogenesis to conduct a cost-effectiveness analysis comparing the 'Choice' and 'Standard of care screening' interventions among un/under-screened African-American women in the Mississippi Delta.

Results: When each intervention was simulated every 5 years from ages 25 to 65 years, the 'Standard of care screening' strategy reduced cancer risk by 6.4% and was not an efficient strategy; 'Choice' was more effective and efficient, reducing lifetime risk of cervical cancer by 14.8% and costing $62,720 per year of life saved (YLS). Screening uptake and colposcopy adherence were key drivers of intervention cost-effectiveness.

Conclusions: Offering 'Choice' to un/underscreened African-American women in the Mississippi Delta led to greater uptake than CHW-facilitated screening at the Health Department, and may be cost-effective.

Impact: We evaluated the cost-effectiveness of an HPV self-collection intervention to reduce disparities.
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http://dx.doi.org/10.1158/1055-9965.EPI-20-1673DOI Listing
March 2021

SARS-CoV-2 cell tropism and multiorgan infection.

Cell Discov 2021 Mar 23;7(1):17. Epub 2021 Mar 23.

Department of Forensic Medicine, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, 430010, China.

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http://dx.doi.org/10.1038/s41421-021-00249-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987126PMC
March 2021

Human Umbilical Cord Mesenchymal Stem Cells Improve Ovarian Function in Chemotherapy-Induced Premature Ovarian Failure Mice Through Inhibiting Apoptosis and Inflammation via a Paracrine Mechanism.

Reprod Sci 2021 Mar 9. Epub 2021 Mar 9.

Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.

Human umbilical cord mesenchymal stem cell (UC-MSC) application is a promising arising therapy for the treatment of premature ovarian failure (POF). However, little is known about the inflammation regulatory effects of human umbilical cord MSCs (UC-MSCs) on chemotherapy-induced ovarian damage, regardless of in vivo or in vitro. This study was designed to investigate the therapeutic effects of UC-MSC transplantation and underlying mechanisms regarding both apoptosis and inflammation in POF mice. The chemotherapy-induced POF models were induced by intraperitoneal injection of cyclophosphamide. Ovarian function parameters, granulosa cell (GC) apoptosis, and inflammation were examined. Morphological staining showed that UC-MSC treatment increased the ovary size, and the numbers of primary and secondary follicles, but decreased the number of atretic follicles. Estradiol levels in the UC-MSC-treated group were increased while follicle-stimulating hormone levels were reduced compared to those in the POF group. UC-MSCs inhibited cyclophosphamide-induced GC apoptosis and inflammation. Meanwhile, phosphorylation of AKT and P38 was elevated after UC-MSC treatment. Tracking of UC-MSCs in vivo indicated that transplanted UC-MSCs were only located in the interstitium of ovaries rather than in follicles. Importantly, UC-MSC-derived extracellular vesicles protected GCs from alkylating agent-induced apoptosis and inflammation in vitro. Our results suggest that UC-MSC transplantation can reduce ovary injury and improve ovarian function in chemotherapy-induced POF mice through anti-apoptotic and anti-inflammatory effects via a paracrine mechanism.
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http://dx.doi.org/10.1007/s43032-021-00499-1DOI Listing
March 2021

Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro.

Cell Discov 2020 Mar 18;6(1):16. Epub 2020 Mar 18.

State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China.

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http://dx.doi.org/10.1038/s41421-020-0156-0DOI Listing
March 2020

Efficacy and safety of PEGylated exenatide injection (PB-119) in treatment-naive type 2 diabetes mellitus patients: a Phase II randomised, double-blind, parallel, placebo-controlled study.

Diabetologia 2021 May 9;64(5):1066-1078. Epub 2021 Mar 9.

Department of Endocrinology, Suzhou Municipal Hospital, Suzhou, China.

Aims/hypothesis: Glucagon-like peptide 1 receptor agonists (GLP-1 RA) such as exenatide are used as monotherapy and add-on therapy for maintaining glycaemic control in patients with type 2 diabetes mellitus. The current study investigated the safety and efficacy of once-weekly PB-119, a PEGylated exenatide injection, in treatment-naive patients with type 2 diabetes.

Methods: In this Phase II, randomised, placebo-controlled, double-blind study, we randomly assigned treatment-naive Chinese patients with type 2 diabetes in a 1:1:1:1 ratio to receive subcutaneous placebo or one of three subcutaneous doses of PB-119 (75, 150, and 200 μg) for 12 weeks. The primary endpoint was the change in HbA from baseline to week 12, and other endpoints were fasting plasma glucose, 2 h postprandial glucose (PPG), and proportion of patients with HbA < 53 mmol/mol (<7.0%) and ≤48 mmol/mol (≤6.5%) at 2, 4, 8 and 12 weeks of treatment. Safety was assessed in all patients who received at least one dose of study drug.

Results: We randomly assigned 251 patients to one of the four treatment groups (n = 62 in placebo and 63 each in PB-119 75 μg, 150 μg and 200 μg groups). At the end of 12 weeks, mean differences in HbA in the treatment groups were -7.76 mmol/mol (95% CI -9.23, -4.63, p < 0.001) (-0.72%, 95% CI -1.01, -0.43), -12.89 mmol/mol (95% CI -16.05, -9.72, p < 0.001) (-1.18%, 95% CI -1.47, -0.89) and -11.14 mmol/mol (95% CI -14.19, -7.97, p <0 .001) (-1.02%, 95% CI -1.30, -0.73) in the 75 μg, 150 μg and 200 μg PB-119 groups, respectively, compared with that in the placebo group after adjusting for baseline HbA. Similar results were also observed for other efficacy endpoints across different time points. There was no incidence of treatment-emergent serious adverse event, severe hypoglycaemia or death.

Conclusions/interpretation: All tested PB-119 doses had superior efficacy compared with placebo and were safe and well tolerated over 12 weeks in treatment-naive Chinese patients with type 2 diabetes.

Trial Registration: ClinicalTrials.gov NCT03520972 FUNDING: The study was funded by National Major Scientific and Technological Special Project for Significant New Drugs Development and PegBio.
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http://dx.doi.org/10.1007/s00125-021-05392-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012337PMC
May 2021

An open-label, pilot study of veliparib and lapatinib in patients with metastatic, triple-negative breast cancer.

Breast Cancer Res 2021 Mar 4;23(1):30. Epub 2021 Mar 4.

Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL, USA.

Background: Poly (ADP-ribose)-polymerase inhibitors (PARPi) have been approved for cancer patients with germline BRCA1/2 (gBRCA1/2) mutations, and efforts to expand the utility of PARPi beyond BRCA1/2 are ongoing. In preclinical models of triple-negative breast cancer (TNBC) with intact DNA repair, we have previously shown an induced synthetic lethality with combined EGFR inhibition and PARPi. Here, we report the safety and clinical activity of lapatinib and veliparib in patients with metastatic TNBC.

Methods: A first-in-human, pilot study of lapatinib and veliparib was conducted in metastatic TNBC (NCT02158507). The primary endpoint was safety and tolerability. Secondary endpoints were objective response rates and pharmacokinetic evaluation. Gene expression analysis of pre-treatment tumor biopsies was performed. Key eligibility included TNBC patients with measurable disease and prior anthracycline-based and taxane chemotherapy. Patients with gBRCA1/2 mutations were excluded.

Results: Twenty patients were enrolled, of which 17 were evaluable for response. The median number of prior therapies in the metastatic setting was 1 (range 0-2). Fifty percent of patients were Caucasian, 45% African-American, and 5% Hispanic. Of evaluable patients, 4 demonstrated a partial response and 2 had stable disease. There were no dose-limiting toxicities. Most AEs were limited to grade 1 or 2 and no drug-drug interactions noted. Exploratory gene expression analysis suggested baseline DNA repair pathway score was lower and baseline immunogenicity was higher in the responders compared to non-responders.

Conclusions: Lapatinib plus veliparib therapy has a manageable safety profile and promising antitumor activity in advanced TNBC. Further investigation of dual therapy with EGFR inhibition and PARP inhibition is needed.

Trial Registration: ClinicalTrials.gov , NCT02158507 . Registered on 12 September 2014.
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http://dx.doi.org/10.1186/s13058-021-01408-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934554PMC
March 2021

Inhibition of PDE1-B by Vinpocetine Regulates Microglial Exosomes and Polarization Through Enhancing Autophagic Flux for Neuroprotection Against Ischemic Stroke.

Front Cell Dev Biol 2020 4;8:616590. Epub 2021 Feb 4.

Department of Neurology and Stroke Center, The First Affiliated Hospital, Jinan University, Guangzhou, China.

Exosomes contribute to cell-cell communications. Emerging evidence has shown that microglial exosomes may play crucial role in regulation of neuronal functions under ischemic conditions. However, the underlying mechanisms of microglia-derived exosome biosynthesis are largely unknown. Herein, we reported that the microglial PDE1-B expression was progressively elevated in the peri-infarct region after focal middle cerebral artery occlusion. By an oxygen-glucose-deprivation (OGD) ischemic model in cells, we found that inhibition of PDE1-B by vinpocetine in the microglial cells promoted M2 and inhibited M1 phenotype. In addition, knockdown or inhibition of PDE1-B significantly enhanced the autophagic flux in BV2 cells, and vinpocetine-mediated suppression of M1 phenotype was dependent on autophagy in ischemic conditions. Co-culture of BV2 cells and neurons revealed that vinpocetine-treated BV2 cells alleviated OGD-induced neuronal damage, and treatment of BV2 cells with 3-MA abolished the observed effects of vinpocetine. We further demonstrated that ischemia and vinpocetine treatment significantly altered microglial exosome biogenesis and release, which could be taken up by recipient neurons and regulated neuronal damage. Finally, we showed that the isolated exosome from conditioned BV2 cells is sufficient to regulate cortical neuronal survival . Taken together, these results revealed a novel microglia-neuron interaction mediated by microglia-derived exosomes under ischemic conditions. Our findings further suggest that PDE1-B regulates autophagic flux and exosome biogenesis in microglia which plays a crucial role in neuronal survival under cerebral ischemic conditions.
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http://dx.doi.org/10.3389/fcell.2020.616590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889976PMC
February 2021

Erratum to comprehensive bioinformatics analysis of the TP53 signaling pathway in Wilms' tumor.

Ann Transl Med 2021 Jan;9(1):96

Department of Pediatric Surgery, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.

[This corrects the article DOI: 10.21037/atm-20-6047.].
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http://dx.doi.org/10.21037/atm-2020-43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859745PMC
January 2021

Iodine-125 Seeds Combined With Biliary Stent Placement Versus Stent Placement Alone For Unresectable Malignant Biliary Obstruction: A Meta-Analysis Of Randomized Controlled Trials.

J Cancer 2021 1;12(5):1334-1342. Epub 2021 Jan 1.

Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009.

Malignant biliary obstruction is always caused by tumors which are unresectable so that palliative stent placement is conducted for drainage of bile duct tree. Recently, irradiation stent with I seeds has been used to improve the stent patency and survival time of patients. We conducted this meta-analysis to evaluate the therapeutic efficacy and safety of biliary stent placement with I seeds compared with stent placement alone in patients with malignant biliary obstruction. We searched Pubmed, Web of Science, ClinicalTrials.gov, Cochrane Library, Embase and CNKI databases for all relevant studies up to 1 May 2020. Patient survival, stent patency, and adverse events were the primary outcome measured. Also, Review Manager 5.3 and Stata/SE15.0 were used to perform the analysis. Eleven randomized controlled trials with a total of 767 patients were included for meta-analysis. Stent combined with I seeds showed lower risk of stent occlusion at 3 month (Odds Ratios(OR) = 0.15; 95%CI: 0.05-0.49, =0.002), 6 month (OR = 0.18; 95%CI: 0.08-0.44, = 0.0001), 9 month (OR = 0.10; 95%CI: 0.05-0.20, < 0.00001) and 1 year (OR = 0.15; 95%CI: 0.07-0.31, < 0.00001) and better mean survival (MD = 125days; 95% CI 91-159 days; P < 0.00001) compared with stent placement alone. Also, reconstructed Kaplan-Meier data demonstrated improved survival in patients treated with stent plus I seeds (hazard ratio(HR)= 1.886; 95% CI: 1.609 to 2.210; P < 0.0001) Moreover, our analysis did not show significant difference between the two groups about the risk of adverse events including abdominal pain, hemobilia, pancreatitis, cholangitis and cholecystitis. I seeds combined with stent demonstrated superior stent patency and improved survival time compared to stent alone with acceptable complications.
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http://dx.doi.org/10.7150/jca.49663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847662PMC
January 2021

Zwitterionic Conjugated Polymer as the Single Component for Photoacoustic-Imaging-Guided Dual-Modal Near-Infrared Phototherapy.

ACS Biomater Sci Eng 2020 07 2;6(7):4005-4011. Epub 2020 Jun 2.

Panzhihua Central Hospital, No. 34 Yikang Street, Panzhihua Avenue, Panzhihua 617000, Sichuan, P. R. China.

Systems consisting of different functional components that synergistically increase the antitumor efficiency of different cancer therapies are in great demand. Here, we report the use of nanoparticles (NPs) composed of a zwitterionic conjugated polymer, generating reactive oxygen species (ROS) and heat. These NPs are more effective in antitumor than single photodynamic therapy (PDT) or photothermal therapy (PTT) and have an optimal absorbance ranging from 700 to 850 nm. Light in this range is capable of reaching tumors by penetrating deep into tissues. The simultaneous PDT and PTT using a single near-infrared (NIR) light can be monitored via photoacoustic imaging (PAI). Treatment of tumor-bearing nude mice with combined PDT and PTT following tail vein injection of NPs resulted in complete tumor remission. No tumor relapse was observed during a 20 day treatment. These zwitterionic conjugated polymeric NPs with the capability of generating ROS and heat show great potential for PAI-guided photodynamic/photothermal dual-modal therapy.
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http://dx.doi.org/10.1021/acsbiomaterials.0c00206DOI Listing
July 2020

A systematic review of synthetic tyrosinase inhibitors and their structure-activity relationship.

Crit Rev Food Sci Nutr 2021 Jan 18:1-42. Epub 2021 Jan 18.

College of Food Science and Technology, Shanghai Ocean University, Shanghai, China.

Tyrosinase is a copper-containing oxidation enzyme, which is responsible for the production of melanin. This enzyme is widely distributed in microorganisms, animals and plants, and plays an essential role in undesirable browning of fruits and vegetables, antibiotic resistance, skin pigment formation, sclerotization of cuticle, neurodegeneration, etc. Hence, it has been recognized as a therapeutic target for the development of antibrowning agents, antibacterial agents, skin-whitening agents, insecticides, and other therapeutic agents. With great potential application in food, agricultural, cosmetic and pharmaceutical industries, a large number of synthetic tyrosinase inhibitors have been widely reported in recent years. In this review, we systematically summarized the advances of synthetic tyrosinase inhibitors in the literatures, including their inhibitory activity, cytotoxicity, structure-activity relationship (SAR), inhibition kinetics, and interaction mechanisms with the enzyme. The collected information is expected to provide a rational guidance and effective strategy to develop novel, potent and safe tyrosinase inhibitors for better practical applications in the future.
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http://dx.doi.org/10.1080/10408398.2021.1871724DOI Listing
January 2021

The complete chloroplast genome sequence of the medicinal plant (Labiatae).

Mitochondrial DNA B Resour 2020 Jul 9;5(3):2721-2722. Epub 2020 Jul 9.

Guangdong Key Laboratory for Crops Genetic Improvement, Crops Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou, China.

is an important traditional Chinese medicine and edible plant resource in China. In this work, we sequenced the complete chloroplast genome of and researched its evolution. The genome size is 152,547 bp, with 37.89% GC content, including a large single copy region (LSC) of 83,482 bp, a small single copy region (SSC) of 17,725 bp and a pair of inverted repeats region (IRs) of 25,670 bp. The complete chloroplast genome was predicted to encode 131 genes, consist of 86 protein-coding genes, 37 tRNA genes and 8 rRNA genes. Phylogenetic analysis showed that was closely related to other Labiatae species .
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http://dx.doi.org/10.1080/23802359.2020.1788433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782758PMC
July 2020

COVID-19 and male reproduction: Current research and unknown factors.

Andrology 2021 Jan 11. Epub 2021 Jan 11.

Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: The testes are suspected target organs of SARS-CoV-2. However, the results of studies on the effect of COVID-19 on male reproduction are controversial.

Objective: To summarize current research on the effects of COVID-19 on male reproduction.

Methods: A systematic review of English literature was performed using PubMed and Ovid Embase up to 18 August 2020. Research articles on the presence of SARS-CoV-2 in semen, the effects of the virus on semen parameters and any pathological changes in the testes were evaluated.

Results: Fourteen studies were included in this review. Six of 176 survivors (3.4%) and 1 of 13 decedents (7.7%) in 2 of 12 studies were positive for viral RNA in semen and testicular tissue, respectively. After stratification of patient groups, we found that the virus was detected in the relatively early stage of infection, 6-16 days after disease onset, in semen from survivors. Two of 3 studies reported that some participants had substandard semen quality after COVID-19, and 1 study found that COVID-19 may impair semen quality in a severity-related manner. Pathological analyses showed that injuries to the seminiferous tubule occurred in all decedents (N = 11). Another study found that orchitic and testis fibrin microthrombi occurred in patients with fatal disease (100%, N = 2). Scrotal discomfort of orchiepididymitis or spermatic cord inflammation has also been reported in COVID-19 patients.

Conclusion: Current studies suggest that semen is rarely considered a carrier of SARS-CoV-2 genetic material during the infection period but not in the semen of recovered patients. Fatal COVID-19 may cause testicular structure damage without the presence of virus.
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http://dx.doi.org/10.1111/andr.12970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8013647PMC
January 2021

Enhanced coupling efficiency and electrical property in surface plasmon-enhanced light-emitting diodes with the tapered Ag structure.

Opt Express 2020 Nov;28(24):35708-35715

We design, fabricate and analyze plasmon-enhanced LEDs with the tapered Ag structure that significantly increases plasmonic coupling efficiency at a coupling distance far beyond the penetration depth. The electroluminescence intensity showed a 16-fold increase compared with planar LEDs with a coupling distance of 100 nm. The enhanced coupling efficiency with large distance is originated from the accumulated SP energy at the metal conical tip and the missing momentum provided by the corrugated surface. Therefore, the SP-enhanced LED with tapered Ag structure can maintain a high luminous efficiency and a stable working state even with thick p-GaN layer, which also guarantees a high electrical performance. Our study paves the way for a practical implementation of SP-enhanced LEDs with excellent optical and electrical properties.
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http://dx.doi.org/10.1364/OE.405626DOI Listing
November 2020

Facile synthesis of nitrogen-doped reduced graphene oxide/nickel ferrite hybrid nanocomposites with superior electromagnetic wave absorption performance in the X-band.

J Colloid Interface Sci 2021 Mar 20;585:538-548. Epub 2020 Oct 20.

School of Chemical Engineering, Anhui University of Science and Technology, Huainan 232001, People's Republic of China.

In this work, nitrogen-doped reduced graphene oxide/nickel ferrite (NRGO/NiFeO) hybrid nanocomposites were synthesized by a one-pot hydrothermal method. Results manifested that the as-synthesized NiFeO nanoparticles displayed hexagonal morphology with a mean size of 40 nm. Moreover, it was found that the entangled structure consisting of crumpled RGO and hexagonal NiFeO nanoparticles was well constructed in the as-fabricated hybrid nanocomposites. Furthermore, the additive volumes of hydrazine hydrate and filler loadings had significant influences on the electromagnetic wave (EMW) absorption properties of obtained nanocomposites. Remarkably, the NRGO/NiFeO hybrid nanocomposite with 15 mL additive volume of hydrazine hydrate showed the optimal reflection loss of -54.4 dB at 9.2 GHz (X band) under a matching thickness of 2.2 mm and maximum absorption bandwidth of 4.5 GHz (13.5-18 GHz) at a very thin thickness of only 1.5 mm. The dual absorption peaks located at the low and high frequency regions could be achieved by facilely modulating the matching thicknesses. In addition, the underlying EMW absorption mechanisms were uncovered. Therefore, our results could shed light on the design and fabrication of graphene-based dielectric/magnetic hybrid composites as light-weight and high-efficiency EMW absorbers.
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http://dx.doi.org/10.1016/j.jcis.2020.10.034DOI Listing
March 2021

Social support and diabetes distress among adults with type 2 diabetes covered by Alabama Medicaid.

Diabet Med 2021 Apr 7;38(4):e14503. Epub 2021 Jan 7.

Division of Preventive Medicine, Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

Aims: Diabetes distress affects approximately 36% of adults with diabetes and is associated with worse diabetes self-management and poor glycaemic control. We characterized participants' diabetes distress and studied the relationship between social support and diabetes distress.

Methods: In this cross-sectional study, we surveyed a population-based sample of adults with type 2 diabetes covered by Alabama Medicaid. We used the Diabetes Distress Scale assessing emotional burden, physician-related, regimen-related and interpersonal distress. We assessed participants' level of diabetes-specific social support and satisfaction with this support, categorized as low or moderate-high. We performed multivariable logistic regression of diabetes distress by level of and satisfaction with social support, adjusting for demographics, disease severity, self-efficacy and depressive symptoms.

Results: In all, 1147 individuals participated; 73% were women, 41% White, 58% Black and 3% Hispanic. Low level of or satisfaction with social support was reported by 11% of participants; 7% of participants had severe diabetes distress. Participants with low satisfaction with social support were statistically significantly more likely to have severe diabetes distress than those with moderate-high satisfaction, adjusted odds ratio 2.43 (95% CI 1.30, 4.54).

Conclusions: Interventions addressing diabetes distress in adults with type 2 diabetes may benefit from a focus on improving diabetes-specific social support.
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http://dx.doi.org/10.1111/dme.14503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979501PMC
April 2021

Given a choice between self-sampling at home for HPV testing and standard of care screening at the clinic, what do African American women choose? Findings from a group randomized controlled trial.

Prev Med 2021 01 16;142:106358. Epub 2020 Dec 16.

Albert Einstein College of Medicine, New York, NY, United States of America; National Cancer Institute, Bethesda, MD, United States of America. Electronic address:

The goals of this study were to: (1) evaluate adherence to cervical cancer screening using a patient-centered approach that provided a choice of self-sampling at home for human papillomavirus (HPV) testing or standard of care screening at the local health department ('Choice') versus only standard of care screening at the local health department ('SCS') among un/under-screened African-American women; and (2) examine whether women given a choice were more likely to choose and adhere to self-sampling for HPV testing. We conducted a group randomized trial among un/under-screened African-American women in the Mississippi Delta, with "town" as the unit of randomization (12 towns). Both interventions (i.e., 'Choice' versus 'SCS') were delivered by Community Health Workers (CHWs) through a door-to-door approach. A total of 335 women were enrolled in the study from 2016 to 2019. The 'Choice' arm had a significantly (p = 0.005) higher adherence to screening compared to the 'SCS' arm after adjusting for the cluster effect and other relevant behavioral variables. Participants in the 'Choice' arm were 5.62 (95% CI 1.71-18.44) times more likely to adhere to cervical cancer screening compared to participants in the 'SCS' arm. Women in the 'Choice' arm were significantly more likely to choose (76%) and adhere to self-sampling at home for HPV testing (48% adherence) compared to standard of care screening at the local health department (7.5% adherence). A theory-driven, CHW-led intervention can effectively promote cervical cancer screening among un/under-screened African-American women in a rural setting when women are provided with a choice between two screening modalities. Clinical Trials Registration: NCT03713710.
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http://dx.doi.org/10.1016/j.ypmed.2020.106358DOI Listing
January 2021

A multi-center randomized controlled trial of the LenoMed ATA-I-1-0 insulin pump for the intensive treatment of diabetic patients.

Ann Transl Med 2020 Nov;8(22):1485

Department of Endocrinology, The First Medical Center of PLA General Hospital, Beijing, China.

Background: Continuous subcutaneous insulin infusion (CSII) is an effective method for managing diabetes. The aim of this study was to evaluate the efficacy and safety of the LenoMed ATA-I-1-0 insulin pump for the treatment of patients with type 1 and type 2 diabetes, compared to the Medtronic MMT-712 insulin pump.

Methods: A total of 120 subjects with diabetes needing insulin treatment were recruited, and 104 completed the trial. The intervention and control group used the LenoMed and Medtronic insulin pump, respectively. The primary outcome was a reduction in fasting plasma glucose. Secondary outcomes included blood glucose control at 7 time points (before and after each meal, and before sleep), hemoglobin A1c (HbA1c) levels at 1 time point, and accuracy and safety of the pumps.

Results: In the per protocol set of 104 subjects, a significant drop in fasting plasma glucose levels was observed for 98.0% subjects in the intervention group and 92.7% in the control group. There was no statistically significant difference between groups [5.23%; 95% confidence interval (CI): -2.69% -13.2%]. Compared to baseline, levels of blood glucose and HbA1c dropped (P<0.001) at a similar magnitude in both groups. The accuracy and alarm effectiveness was 100%. No adverse event or severe adverse event related to the medication occurred in the study.

Conclusions: The novel injection equipment, the LenoMed ATA-I-1-0 insulin pump, demonstrated efficacy and a good safety profile, and was not inferior to the widely used Medtronic MMT-712 insulin pump. Thus, our study suggests that the LenoMed ATA-I-1-0 insulin pump can be widely used in clinical practice.
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http://dx.doi.org/10.21037/atm-20-6024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7729342PMC
November 2020

Genetic variants of ABCC8 and phenotypic features in Chinese early onset diabetes.

J Diabetes 2020 Dec 9. Epub 2020 Dec 9.

Department of Endocrinology and Metabolism, Peking University People's Hospital, Peking University Diabetes Center, Beijing, China.

Background: ABCC8 variants cause neonatal diabetes, maturity onset diabetes of the young (MODY), and hyperinsulinemic hypoglycemia because of activating or inactivating variants. In this study we used targeted exon sequencing to investigate genetic variants of ABCC8 and phenotypic features in Chinese patients with early onset diabetes (EOD).

Methods: A cross-sectional study of 543 Chinese patients with EOD was recruited and the exons of them were conducted targeted sequencing. The pathogenicity of ABCC8 variants was defined according to the American College of Medical Genetics and Genomics and the Association for Molecular Pathology guideline. The phenotypes of patients owing to ABCC8 variants (ABCC8-MODY) were characterized.

Results: Among the 543 participants, eight (1.5%) patients with ABCC8-MODY were identified. They harbored eight missense ABCC8 variants (p.R306C, p.E1326K, and p.R1379H, previously reported; p.R298C, p.F1176C, p.R1221W, p.K1358R, and p.I1404V) classified as likely pathogenic. Two family members with ABCC8-MODY were also confirmed. The average diagnosed age of the 10 patients was 26.8 ± 12.9 years. The majority of them had unsatisfactory glucose control, 80% of them had diabetic kidney disease, and neurological features were not observed.

Conclusion: Using targeted exon sequencing followed by pathogenicity analysis, we could be able to make genetic diagnoses for eight (1.5%) patients with ABCC8-MODY. The phenotype was variable with higher risk of diabetic microvascular complications. Genetic diagnosis is conducive for facilitating the personalized treatment of ABCC8-MODY.
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http://dx.doi.org/10.1111/1753-0407.13144DOI Listing
December 2020

Infection of human sweat glands by SARS-CoV-2.

Cell Discov 2020 Nov 13;6(1):84. Epub 2020 Nov 13.

State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei 430071, China.

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http://dx.doi.org/10.1038/s41421-020-00229-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661176PMC
November 2020

Low-Frequency Genetic Variant in the Hepatic Glucokinase Gene Is Associated With Type 2 Diabetes and Insulin Resistance in Chinese Population.

Diabetes 2021 Mar 9;70(3):809-816. Epub 2020 Dec 9.

Departments of Endocrinology and Metabolism, Peking University People's Hospital, Peking University Diabetes Center, Beijing, China

Glucokinase (GCK) regulates insulin secretion and hepatic glucose metabolism, and its inactivating variants could cause diabetes. We aimed to evaluate the association of a low-frequency variant of GCK (rs13306393) with type 2 diabetes (T2D), prediabetes, or both (impaired glucose regulation [IGR]) in a Chinese population. An association study was first conducted in a random cluster sampling population (sample 1: 537 T2D, 768 prediabetes, and 1,912 control), and then another independent population (sample 2: 3,896 T2D, 2,301 prediabetes, and 868 control) was used to confirm the findings in sample 1. The A allele of rs13306393 was associated with T2D (odds ratio 3.08 [95% CI 1.77-5.36], = 0.00007) in sample 1; rs13306393 was also associated with prediabetes (1.67 [1.05-2.65], = 0.03) in sample 2. In a pooled analysis of the two samples, the A allele increased the risk of T2D (1.57 [1.15-2.15], = 0.005), prediabetes (1.83 [1.33-2.54], = 0.0003) or IGR (1.68 [1.26-2.25], = 0.0004), insulin resistance estimated by HOMA (β = 0.043, = 0.001), HbA (β = 0.029, = 0.029), and urinary albumin excretion (β = 0.033, = 0.025), irrespective of age, sex, and BMI. Thus, the Chinese-specific low-frequency variant increased the risk of T2D through reducing insulin sensitivity rather than islet β-cell function, which should be considered in the clinical use of GCK activators in the future.
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http://dx.doi.org/10.2337/db20-0564DOI Listing
March 2021

Modelling the effects of invasion on the landscape succession of Yancheng coastal natural wetlands, China.

PeerJ 2020 24;8:e10400. Epub 2020 Nov 24.

School of Marine Science and Engineering, Nanjing Normal University, Nanjing, China.

Background: The Yancheng coastal natural wetlands (YCNR) are well-preserved silty tidal flat wetlands in China. Due to the severe invasion of , the native ecosystem has undergone great changes. The successful invasion of reduced the biodiversity of the YCNR, changed the structure and function of the local ecosystem, and eventually led to the degradation of the ecosystem and the loss of ecosystem function and service. Fully understanding the impact of an alien species invasion on YCNR succession is an important prerequisite for protecting and restoring the wetlands.

Methods: In this study, remote sensing, GIS technology, and a cellular-automaton Markov model were used to simulate the natural succession process of native ecosystems without being affected by alien species. By comparing the landscape of the YCNR with the model simulation results, we gained a better understanding of how alien species affect native landscape-scale ecosystems.

Results: During the natural succession of the coastal native wetland ecosystem in the YCNR, the pioneer species occupied the mudflats and expanded seaward. The whole area expanded and moved seaward with an average annual movement of 58.23 m. Phragmites australis seemed to dominate the competition with communities, and the area gradually expanded with an average annual movement of 39.89 m. The invasion of changed the native ecosystem's spatial succession process, causing the ecosystem to be stressed by ecosystems on the side of the sea () and that of land (). The area of the seaward-expanding ecosystem has been declining. Under a reasonable protected area policy, human activities have enhanced the succession rate of the P. australis ecosystem and have had a small impact on the ecological spatial succession of and .
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http://dx.doi.org/10.7717/peerj.10400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694568PMC
November 2020

Improving air barrier, water vapor permeability properties of cellulose paper by layer-by-layer assembly of graphene oxide.

Carbohydr Polym 2021 Feb 19;253:117227. Epub 2020 Oct 19.

School of Light Industry and Chemical Engineering, Dalian Polytechnic University, Dalian 116034, Liaoning, China. Electronic address:

A paper-based packaging material with improved air barrier and water vapor permeability (WVP) properties was synthesized based on layer-by-layer assembly consisted of poly(ethylenimine) (PEI)/graphene oxide (GO) on a filter paper substrate. The effect of the pH of GO suspension on the zeta potential and air permeability (AP) of the modified paper was investigated in detail. The results indicated that the pH of GO suspension resulted in significant difference in the AP of the modified paper. Compare with the pristine paper, the AP of the modified paper with (PEI/GO) multilayer films synthesized at pH 2.5 decreased by 99.99 %, while the WVP increased by 15.82 %. The modified paper as packaging material could prolong the shelf-life of oyster mushroom, indicating the modified paper has huge potential application on the preservation of agricultural products.
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http://dx.doi.org/10.1016/j.carbpol.2020.117227DOI Listing
February 2021

The impact of ferritin on the disassociation of HbA1c and mean plasma glucose.

J Diabetes 2020 Nov 29. Epub 2020 Nov 29.

Department of Endocrinology and Metabolism, Peking University People's Hospital, Beijing, China.

Objective: To explore the impact of ferritin level on the disassociation of glycated hemoglobin A1c (HbA1c) and mean plasma glucose (MPG).

Reseach Design And Methods: We used a 2012-2013 cross-sectional survey conducted in Pinggu district, Beijing including 3095 Chinese participants aged 25-75 years. We categorized their glycemic status by interviewing for diagnosed diabetes and by measuring HbA1c, fasting plasma glucose (FPG), and 2-hours post-load plasma glucose (2-hours PPG). We fitted a multivariable regression model to explore the impact of ferritin on the association of HbA1c or glycated albumin (GA) and mean plasma glucose.

Results: A total of 5.65% of participants were diagnosed as diabetes using HbA1c criteria, and 9.79% using oral glucose tolerance test criteria. Compared with males, females had significantly lower hemoglobin levels (159.82 ± 11.56 vs 135.93 ± 12.62) and lower ferritin levels (113.00 [68.55, 185.50] vs 33.40 [12.40, 70.13]). Linear regression analysis performed in different groups classified by different diagnose criterion indicated that the correlation between MPG and HbA1c differs in different tertiles of ferritin (lowest vs middle vs highest: R = 0.507 vs 0.645 vs 0.687 in female; R = 0.415 vs 0.715 vs 0.615 in male), and the association between MPG and HbA1c diminished in the lowest tertile of ferritin.

Conclusions: Ferritin level might affect the association between glucose and HbA1c, which should be taken into account when using HbA1c as a diagnosis criterion for diabetes and prediabetes.
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http://dx.doi.org/10.1111/1753-0407.13138DOI Listing
November 2020

Reversibility of hAT-MSCs phenotypic and metabolic changes after exposure to and withdrawal from HCC-conditioned medium through regulation of the ROS/MAPK/HIF-1α signaling pathway.

Stem Cell Res Ther 2020 11 27;11(1):506. Epub 2020 Nov 27.

Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China.

Background: Mesenchymal stem cells (MSCs) play an important role in tumor progression; concomitantly, MSCs also undergo profound changes in the tumor microenvironment (TME). These changes can directly impact the application and efficacy of MSC-based anti-tumor therapy. However, few studies have focused on the regulation of MSC fate in TME, which will limit the progress of MSC-based anti-tumor therapy. Herein, we investigated the effects of conditioned medium from human hepatocellular carcinoma cells (HCC-CM) on the phenotype and glucose metabolism of human adipose tissue-derived MSCs (hAT-MSCs).

Methods: The passage 2 (P2) to passage 3 (P3) hAT-MSCs were exposed to conditioned medium from Hep3B, Huh7 and HCCLM3 cells for 4-8 weeks in vitro. Then, immunofluorescent, CCK-8 assay, EdU assay, Transwell assay, and flow cytometry were used to assess the alterations in cell phenotype in terms of cell morphology, secretory profiles, proliferation, migration, invasion, cell cycle, and apoptosis. In addition, glucose metabolism was evaluated by related kits. Next, the treated hAT-MSCs were subjected to withdrawal from HCC-CM for 2-4 weeks, and alterations in phenotype and glucose metabolism were reevaluated. Finally, the molecular mechanism was clarified by Western blotting.

Results: The results revealed that after exposure to HCC-CM, hAT-MSCs developed a stellate-shaped morphology. In association with cytoskeleton remodeling, hAT-MSCs showed enhanced capacities for migration and invasion, while cell proliferation was inhibited by regulating the cell cycle by downregulating cyclins and cyclin-dependent kinases and activating the mitochondrial apoptosis pathway. In terms of glucose metabolism, our results showed mitochondrial dysfunction and elevated glycolysis of hAT-MSCs. However, interestingly, when the treated hAT-MSCs were subjected to withdrawal from HCC-CM, the alterations in phenotype and glucose metabolism could be reversed, but secretory phenotype and tumor-promoting properties appear to be permanent. Further studies showed that these changes in hAT-MSCs may be regulated by the ROS/MAPK/HIF-1α signaling pathway.

Conclusion: Taken together, the effects of long-term HCC-CM treatment on phenotype and glucose metabolism in hAT-MSCs are modest and largely reversible after withdrawal, but HCC-CM endow hAT-MSCs with permanent secretory phenotype and tumor-promoting properties. This is the first report on the reversal of phenotype and glucose metabolism in tumor-associated MSCs (TA-MSCs), it is anticipated that new insights into TA-MSCs will lead to the development of novel strategies for MSC-based anti-tumor therapy.
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http://dx.doi.org/10.1186/s13287-020-02010-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694319PMC
November 2020

Feasibility of T1 mapping with histogram analysis for the diagnosis and staging of liver fibrosis: Preclinical results.

Magn Reson Imaging 2021 02 24;76:79-86. Epub 2020 Nov 24.

Department of Radiology, Third Affiliated Hospital of Soochow University, Changzhou & Changzhou First People's Hospital, Jiangsu 213200, China. Electronic address:

Purpose: To compare the diagnostic accuracy of parameters derived from the histogram analysis of precontrast, 10-min hepatobiliary phase (HBP) and 20-min HBP T1 maps for staging liver fibrosis (LF).

Methods: LF was induced in New Zealand white rabbits by subcutaneous injections of carbon tetrachloride for 4-16 weeks (n = 120), and 20 rabbits injected with saline served as controls. Precontrast, 10-min and 20-min HBP modified Look-Locker inversion recovery (MOLLI) T1 mapping was performed. Histogram analysis of T1 maps was performed, and the mean, median, skewness, kurtosis, entropy, inhomogeneity and 10th/25th/75th/90th percentiles of T1, T1 and T1 were derived. Quantitative histogram parameters were compared. For significant parameters, further receiver operating characteristic (ROC) analyses were performed to evaluate the potential diagnostic performance in differentiating LF stages.

Results: Finally, 17, 20, 21, 21 and 20 rabbits were included for the F0, F1, F2, F3, and F4 pathological grades of fibrosis, respectively. The mean/75th of T1, entropy of T1 and entropy/mean/median/10th of T1 demonstrated a significant good correlation with the LF stage (|r| = 0.543-0.866, all P < 0.05). The 75th of T1, entropy, and entropy were the three most reliable imaging markers in reflecting the stage of LF. The area under the ROC curve of entropy was larger than that of entropy (P < 0.05 for LF ≥ F2, ≥F3, and ≥ F4) and the 75th of T1 (P < 0.05 for LF ≥ F2 and ≥ F3) for staging LF.

Conclusion: Magnetic resonance histogram analysis of T1 maps, particularly the entropy derived from 20-min HBP T1 mapping, is promising for predicting the LF stage.
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http://dx.doi.org/10.1016/j.mri.2020.11.006DOI Listing
February 2021

Exosomal‑miR‑10a derived from colorectal cancer cells suppresses migration of human lung fibroblasts, and expression of IL‑6, IL‑8 and IL‑1β.

Mol Med Rep 2021 Jan 25;23(1). Epub 2020 Nov 25.

The Cancer Institute, Tangshan People's Hospital, Tangshan, Hebei 063001, P.R. China.

MicroRNAs (miRs) carried in exosomes serve an important role in the pre‑metastatic microenvironment and in intercellular interactions. However, the function of exosomal‑miR‑10a derived from primary colorectal cancer (CRC) cells on fibroblasts in the lung metastatic microenvironment of patients with CRC remains unclear. Reverse transcription‑quantitative PCR was performed using samples from patients with CRC, and demonstrated that the expression levels of miR‑10a were significantly lower in serum and cancer tissue samples from patients with CRC compared with in serum from healthy individuals and paired non‑cancerous tissues, respectively. In addition, the expression levels of miR‑10a were inversely associated with the invasion depth of CRC. Exosomal‑miR‑10a derived from CRC cells reduced the proliferative and migratory activities of primary normal human lung fibroblasts (NHLFs), and the expression levels of IL‑6, IL‑8 and IL‑1β in NHLFs. The present study provided insight into the phenotypic alterations of NHLFs induced by exosomal‑miR‑10a derived from CRC cells, which may aid understanding of the mechanism underlying the process of CRC lung metastasis.
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http://dx.doi.org/10.3892/mmr.2020.11723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716406PMC
January 2021

Prevalence of Thyroid Dysfunction in a Chinese Population with Different Glucose Intolerance Status: A Community-Based Cross-Sectional Study.

Diabetes Metab Syndr Obes 2020 16;13:4361-4368. Epub 2020 Nov 16.

Department of Endocrinology and Metabolism, Peking University People's Hospital, Peking University Diabetes Center, Beijing 100044, People's Republic of China.

Aim: Impaired glucose metabolism and thyroid dysfunction (TD) are the two most common chronic metabolic disorders. This study aimed to investigate the epidemiological characteristics of TD in different status of glucose tolerance in a community-based Chinese population and to understand the association between TD and glucose metabolism.

Methods: A community-based population study of metabolic disease was conducted from June 2013 to September 2014 in Beijing, China. Residents aged 26-76 years were selected according to gender and age composition using multi-stage stratified random sampling process. All participants underwent serum thyroid function and thyroid-associated antibody tests. The status of glucose tolerance was determined using 75g-oral glucose tolerance test. Chi-square test was used to compare the differences in prevalence. Multivariate logistic regression analysis was used to determine the impact of insulin resistance (IR) on thyroid function.

Results: By analyzing 3986 participants who were included in the survey, the prevalence of type 2 diabetes (T2DM) and pre-diabetes (pre-DM) was 18.59% and 26.79%, respectively. The prevalence of TD was 8.81%, with overt hyperthyroidism accounting for 0.38%; subclinical hyperthyroidism, 1.86%; overt hypothyroidism, 0.70%; and subclinical hypothyroidism, 5.87%. The prevalence of TD increased with gradually deteriorated glucose tolerance (7.63% in those with normal glucose tolerance, 9.27% in pre-DM, and 11.61% in T2DM) in both men and women. Each unit of higher HOMA-IR was associated with 7% higher likelihood of having subclinical hypothyroidism.

Conclusion: The coexisting of TD with T2DM and pre-DM is high in this community-based Chinese population, suggesting a close relationship between TD and glucose metabolism.
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http://dx.doi.org/10.2147/DMSO.S271328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678694PMC
November 2020

ICEHpsaHPS7, a Novel Multiple Drug Resistance Integrative Conjugative Element in .

Antimicrob Agents Chemother 2021 01 20;65(2). Epub 2021 Jan 20.

Key Laboratory of Bacteriology, Ministry of Agriculture, Nanjing, China

Integrative conjugative elements (ICEs) are a kind of novel self-transmissible mobile genetic element. In this study, a novel ICE was identified in () We confirmed that it could mediate the migration of antimicrobial resistance genes in and found that there may have been a transferring potential between different serovar strains of These findings demonstrate that the ICE is crucial to the horizontal transfer of antimicrobial resistance among strains.
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http://dx.doi.org/10.1128/AAC.01716-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848986PMC
January 2021