Publications by authors named "Yufei Zhao"

98 Publications

Type I collagen promotes tumor progression of integrin β1 positive gastric cancer through a BCL9L/β-catenin signaling pathway.

Aging (Albany NY) 2021 Jul 28;13(undefined). Epub 2021 Jul 28.

Department of Immunology and Rheumatology, The Fourth Hospital of Hebei Medical University, Hebei, China.

The mechanism of extracellular matrix induced tumor progression is poorly understood. Based on the TCGA database and clinical tumor tissues analysis, we observed abundant type I collagen expression in tumor tissues and poor overall survival in gastric patients with high integrin β1 (ITGB1) expression. , our study found that 3D collagen culture promoted the capability of colony formation and growth in ITGB1 positive gastric cancer, whereas limited colony growth was observed in ITGB1 negative gastric cancer, suggesting the role of ITGB1 in type I collagen associated tumor progression. Mechanistically, we demonstrated that type I collagen was capable of promoting the activation of BCL9L/β-catenin signaling pathway through ITGB1, thereby contributing to the gastric cancer development. Subsequently, β-catenin signals further up-regulated the expression anti-apoptosis protein BCL2, leading to the chemo-resistance in gastric cancer cells. Blockade of β-catenin signals efficiently improved the anticancer effects of chemotherapy, providing an innovative sight for clinical gastric cancer therapy.
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http://dx.doi.org/10.18632/aging.203355DOI Listing
July 2021

Topological Transformation of Mg-containing Layered Double Hydroxide Nanosheets for Efficient Photo-driven CH4 Coupling.

Chemistry 2021 Jul 28. Epub 2021 Jul 28.

Beijing University of Chemical Technology, Chemistry, CHINA.

Direct conversion of methane (CH 4 ) to fuels and other high value-added chemicals is an attractive technology in the chemical industry; however, practical challenges under sustainable process remain. Herein, we report the preparation of a heterostructured Co-doped MgO-based catalyst via topological transformation of a MgCo-layered double hydroxide (LDH) calcination from 200 to 1100 o C. The catalyst can remarkably activate CH 4 coupling to produce C 2 H 6 with a selectivity of 41.60% within 3 h under a full-spectrum irradiation when calcination of LDH at 800 o C. Characterization studies and catalytic results suggest that the highly dispersed active sites and large interfaces amongst the Co-doped MgO-based catalyst enable surface activation of CH 4 to methyl (CH 3 *), in turn promoting the coupling of CH 3 * to C 2 H 6 . This study introduces a promising pathway for the photo-driven CH 4 coupling to high value-added chemicals by using layered double hydroxides as a precursor.
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http://dx.doi.org/10.1002/chem.202101428DOI Listing
July 2021

Treatments for Endometritis in Mares Caused by Streptococcus equi Subspecies zooepidemicus: A Structured Literature Review.

J Equine Vet Sci 2021 07 24;102:103430. Epub 2021 Feb 24.

College of Animal Science and Technology, China Agriculture University, Beijing, China. Electronic address:

Bacterial infections are the main causes of endometritis in mares. It is well known that the most common bacterial pathogen is Streptococcus equi subspecies zooepidemicus (SEZ). This structured review was completed according to the PRISMA procedure to search endometritis treatment protocols published between 1990 and 2020 it was our intent to evaluate the actual effects of different treatment protocols for endometritis caused by SEZ. The trials included were collected from Pubmed, CAB and Agricola. Ten articles with 116 horses and 17 different interventions were identified. The results of this structured review indicated that the reported antibiotics, immunomodulatory agents and fresh white blood cell treatments were superior for treating SEZ caused endometritis in mares, whereas oxytocin and uterine lavage alone may not be as effective as presumed. The inclusion and evaluation of more randomized controlled trials may be helpful for further elucidation of the differences.
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http://dx.doi.org/10.1016/j.jevs.2021.103430DOI Listing
July 2021

Spectral signatures of the surface anomalous Hall effect in magnetic axion insulators.

Nat Commun 2021 Jun 10;12(1):3524. Epub 2021 Jun 10.

Shenzhen Institute for Quantum Science and Engineering and Department of Physics, Southern University of Science and Technology, Shenzhen, China.

The topological surface states of magnetic topological systems, such as Weyl semimetals and axion insulators, are associated with unconventional transport properties such as nonzero or half-quantized surface anomalous Hall effect. Here we study the surface anomalous Hall effect and its spectral signatures in different magnetic topological phases using both model Hamiltonian and first-principles calculations. We demonstrate that by tailoring the magnetization and interlayer electron hopping, a rich three-dimensional topological phase diagram can be established, including three types of topologically distinct insulating phases bridged by Weyl semimetals, and can be directly mapped to realistic materials such as MnBiTe/(BiTe) systems. Among them, we find that the surface anomalous Hall conductivity in the axion-insulator phase is a well-localized quantity either saturated at or oscillating around e/2h, depending on the magnetic homogeneity. We also discuss the resultant chiral hinge modes embedded inside the side surface bands as the potential experimental signatures for transport measurements. Our study is a significant step forward towards the direct realization of the long-sought axion insulators in realistic material systems.
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http://dx.doi.org/10.1038/s41467-021-23844-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192549PMC
June 2021

Complete mitochondrial genome of the Small-Branded Swift: (Lepidoptera, Hesperiidae).

Mitochondrial DNA B Resour 2021 May 4;6(5):1599-1600. Epub 2021 May 4.

Key Laboratory of Plant Protection Resources and Pest Management, Ministry of Education, Entomological Museum, College of Plant Protection, Northwest A&F University, Yangling, China.

We report the complete mitochondrial genome of the Small-Branded Swift: , which is an important pest of rice. The total length of the circular double-stranded mitogenome is 15,524 bp, containing 13 protein-coding genes (PCGs), 22 transfer RNAs (tRNAs), 2 ribosomal RNAs (rRNAs) and a non-coding AT-rich region with the nucleotide base composition of 40.07% A, 40.83% T, 11.59% C, and 7.51% G, showing a relatively strong AT bias. The gene order and organization are consistent with typical Lepidoptera species. This work will provide molecular data support for the study of the phylogeny and evolution in the family Hesperiidae.
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http://dx.doi.org/10.1080/23802359.2021.1914523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110179PMC
May 2021

Genetic fate-mapping reveals surface accumulation but not deep organ invasion of pleural and peritoneal cavity macrophages following injury.

Nat Commun 2021 05 17;12(1):2863. Epub 2021 May 17.

State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.

During injury, monocytes are recruited from the circulation to inflamed tissues and differentiate locally into mature macrophages, with prior reports showing that cavity macrophages of the peritoneum and pericardium invade deeply into the respective organs to promote repair. Here we report a dual recombinase-mediated genetic system designed to trace cavity macrophages in vivo by intersectional detection of two characteristic markers. Lineage tracing with this method shows accumulation of cavity macrophages during lung and liver injury on the surface of visceral organs without penetration into the parenchyma. Additional data suggest that these peritoneal or pleural cavity macrophages do not contribute to tissue repair and regeneration. Our in vivo genetic targeting approach thus provides a reliable method to identify and characterize cavity macrophages during their development and in tissue repair and regeneration, and distinguishes these cells from other lineages.
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http://dx.doi.org/10.1038/s41467-021-23197-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129080PMC
May 2021

Irisin induces white adipose tissue browning in mice as assessed by magnetic resonance imaging.

Exp Biol Med (Maywood) 2021 Jul 22;246(14):1597-1606. Epub 2021 Apr 22.

Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, P. R. China.

This study aimed to track and evaluate the effect of low-dose irisin on the browning of white adipose tissue (WAT) in mice using magnetic resonance imaging (MRI) noninvasively . Mature white adipocytes extracted from mice were cultured, induced and characterized before being treated by irisin. The volume and fat fraction of WAT were quantified using MRI in normal chow diet and high fat mice after injection of irisin. The browning of cultured white adipocytes and WAT in mice were validated by immunohistochemistry and western blotting for uncoupling protein 1 (UCP1) and deiodinase type II (DIO2). The serum indexes were examined with high fat diet after irisin intervention. UCP1 and DIO2 in adipocytes showed increases responding to the irisin treatment. The size of white adipocytes in mice receiving irisin intervention was reduced. MRI measured volumes and fat fraction of WAT were significantly lower after Irisin treatment. Blood glucose and cholesterol levels were reduced in high fat diet mice after irisin treatment. Irisin intervention exerted browning of WAT, resulting reduction of volume and fat fraction of WAT as measured by MRI. Furthermore, it improved the condition of mice with diet-induced obesity and related metabolic disorders.
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http://dx.doi.org/10.1177/15353702211006049DOI Listing
July 2021

Neuroanatomy of melanocortin-4 receptor pathway in the mouse brain.

Open Life Sci 2020 13;15(1):580-587. Epub 2020 Aug 13.

College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China.

Objective: Melanocortin-4 receptors (MC4Rs) are key regulators of energy homeostasis and adipose deposition in the central nervous system. Considering that MC4R expression regions and function-related research mainly focus on the paraventricular nucleus (PVN), little is known about their distribution throughout the mouse brain, although its messenger RNA distribution has been analyzed in the rat. Therefore, MC4R protein localization in mouse neurons was the focus of this study.

Methods: MC4R protein distribution was assessed in mice through immunofluorescence and Western blotting.

Results: MC4R was differentially expressed throughout the arcuate nucleus (ARC), nucleus of the solitary tract (NTS), raphe pallidus (RPa), medial cerebellar nucleus, intermediolateral nucleus, and brainstem. The highest MC4R protein levels were found in the ARC and ventromedial hypothalamic nucleus, while they were significantly lower in the parabrachial nucleus and NTS. The lowest MC4R protein levels were found in the PVN; there was no difference in the protein levels between the area postrema and RPa.

Conclusions: These data provide a basic characterization of MC4R-expressing neurons and protein distribution in the mouse brain and may aid further research on its role in energy homeostasis.
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http://dx.doi.org/10.1515/biol-2020-0063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874588PMC
August 2020

Ambient air PM exposure induces heart injury and cardiac hypertrophy in rats through regulation of miR-208a/b, α/β-MHC, and GATA4.

Environ Toxicol Pharmacol 2021 Jul 31;85:103653. Epub 2021 Mar 31.

Institute of Environmental Science, Shanxi University, Taiyuan, China. Electronic address:

Ambient air fine particulate matter (PM) may increase cardiovascular disease risks. In this study, we investigated the miR-208/GATA4/myosin heavy chain (MHC) regulation mechanisms on cardiac injury in rats after PM exposure via an animal inhalation device. The results showed that PM exposure for 2 months caused pathological heart injury, reduced nucleus-cytoplasm ratio, and increased the levels of CK-MB and cTnI, showing cardiac hypertrophy. Oxidative stress and inflammatory responses were also observed in rats' hearts exposed to PM. Of note, PM exposure for 2-month significantly elevated GATA4 and β-MHC mRNA and protein expression compared with the corresponding controls, along with the high-expression of miR-208b. The ratios of β-MHC/α-MHC expression induced by PM were remarkably raised in comparison to their controls. It suggested that the up-regulation of miR-208b/β-MHC and GATA4 and the conversion from α-MHC to β-MHC may be the important causes of cardiac hypertrophy in rats incurred by PM.
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http://dx.doi.org/10.1016/j.etap.2021.103653DOI Listing
July 2021

Highly Accessible Atomically Dispersed Fe-N Sites Electrocatalyst for Proton-Exchange Membrane Fuel Cell.

Adv Sci (Weinh) 2021 Mar 29;8(5):2002249. Epub 2021 Jan 29.

Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical Technology Beijing 100029 P. R. China.

Atomically dispersed transition metal-N sites have emerged as a frontier for electrocatalysis because of the maximized atom utilization. However, there is still the problem that the reactant is difficult to reach active sites inside the catalytic layer in the practical proton exchange membrane fuel cell (PEMFC) testing, resulting in the ineffective utilization of the deeply hided active sites. In the device manner, the favorite structure of electrocatalysts for good mass transfer is vital for PEMFC. Herein, a facile one-step approach to synthesize atomically dispersed Fe-N species on hierarchically porous carbon nanostructures as a high-efficient and stable atomically dispersed catalyst for oxygen reduction in acidic media is reported, which is achieved by a predesigned hierarchical covalent organic polymer (COP) with iron anchored. COP materials with well-defined building blocks can stabilize the dopants and provide efficient mass transport. The appropriate hierarchical pore structure is proved to facilitate the mass transport of reactants to the active sites, ensuring the utilization of active sites in devices. Particularly, the structurally optimized HSAC/Fe-3 displays a maximum power density of up to 824 mW cm, higher than other samples with fewer mesopores. Accordingly, this work will offer inspirations for designing efficient atomically dispersed electrocatalyst in PEMFC device.
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http://dx.doi.org/10.1002/advs.202002249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927611PMC
March 2021

Adaptive Memory Distortions Are Predicted by Feature Representations in Parietal Cortex.

J Neurosci 2021 Mar 22;41(13):3014-3024. Epub 2021 Feb 22.

Department of Psychology, University of Oregon, Eugene, Oregon 97401

Similarity between memories is a primary cause of interference and forgetting. Exaggerating subtle differences between memories is therefore a potential mechanism for reducing interference. Here, we report a human fMRI study ( = 29, 19 female) that tested whether behavioral and neural expressions of memories are adaptively distorted to reduce interference. Participants learned and repeatedly retrieved object images, some of which were identical except for subtle color differences. Behavioral measures of color memory revealed exaggeration of differences between similar objects. Importantly, greater memory exaggeration was associated with lower memory interference. fMRI pattern analyses revealed that color information in parietal cortex was stronger during memory recall when color information was critical for discriminating competing memories. Moreover, greater representational distance between competing memories in parietal cortex predicted greater color memory exaggeration and lower memory interference. Together, these findings reveal that competition between memories induces adaptive, feature-specific distortions in parietal representations and corresponding behavioral expressions. Similarity between memories is a primary cause of interference and forgetting. Here, we show that, when remembering highly similar objects, subtle differences in the features of these objects are exaggerated in memory to reduce interference. These memory distortions are reflected in, and predicted by, overlap of activity patterns in lateral parietal cortex. These findings provide unique insight into how memory interference is resolved and specifically implicate lateral parietal cortex in representing feature-specific memory distortions.
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http://dx.doi.org/10.1523/JNEUROSCI.2875-20.2021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8018893PMC
March 2021

Responses of Defect-Rich Zr-Based Metal-Organic Frameworks toward NH Adsorption.

J Am Chem Soc 2021 Mar 17;143(8):3205-3218. Epub 2021 Feb 17.

Wolfson Catalysis Centre, Department of Chemistry, University of Oxford, Oxford OX1 3QR, U.K.

Understanding structural responses of metal-organic frameworks (MOFs) to external stimuli such as the inclusion of guest molecules and temperature/pressure has gained increasing attention in many applications, for example, manipulation and manifesto smart materials for gas storage, energy storage, controlled drug delivery, tunable mechanical properties, and molecular sensing, to name but a few. Herein, neutron and synchrotron diffractions along with Rietveld refinement and density functional theory calculations have been used to elucidate the responsive adsorption behaviors of defect-rich Zr-based MOFs upon the progressive incorporation of ammonia (NH) and variable temperature. UiO-67 and UiO-bpydc containing biphenyl dicarboxylate and bipyridine dicarboxylate linkers, respectively, were selected, and the results establish the paramount influence of the functional linkers on their NH affinity, which leads to stimulus-tailoring properties such as gate-controlled porosity by dynamic linker flipping, disorder, and structural rigidity. Despite their structural similarities, we show for the first time the dramatic alteration of NH adsorption profiles when the phenyl groups are replaced by the bipyridine in the organic linker. These molecular controls stem from controlling the degree of H-bonding networks/distortions between the bipyridine scaffold and the adsorbed NH without significant change in pore volume and unit cell parameters. Temperature-dependent neutron diffraction also reveals the NH-induced rotational motions of the organic linkers. We also demonstrate that the degree of structural flexibility of the functional linkers can critically be affected by the type and quantity of the small guest molecules. This strikes a delicate control in material properties at the molecular level.
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http://dx.doi.org/10.1021/jacs.0c12483DOI Listing
March 2021

Atomically dispersed Rh-doped NiFe layered double hydroxides: precise location of Rh and promoting hydrazine electrooxidation properties.

Nanoscale 2021 Jan;13(3):1869-1874

State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, P. R. China.

Noble metal-based catalysts have attracted huge attention owing to their intriguing activity and selectivity. Revealing noble metal active sites and keeping them in a form of stable and high loading are crucial to improving the catalytic performance and understanding the reaction mechanism. Herein, a feasible preparation method was used to synthesize a Rh-based ultrathin NiFe layered double hydroxide (Rh/NiFe). The detailed study proved that the existence form of Rh atoms is atomically dispersed. Moreover, extended X-ray absorption fine structure (EXAFS) with theoretical calculation of X-ray absorption near-edge structure (XANES) and density functional theory (DFT) were used to identify at the atomic level the precise location and coordination environment of the introduced Rh atoms. It was found that Rh atoms are doped in the LDH layer in a coplanar position with Ni and Fe atoms. With a 5.4 wt% loading amount of Rh, the modified catalyst of Rh/NiFe-5.4 requires 80 mV less than unmodified ultrathin NiFe layered double hydroxide (NiFe) for hydrazine electrooxidation. The XAFS fitting revealed that the doping of Rh atoms results in the distortion of the laminate and then introduces certain defects, which may be attributed to electron transport, thus endowing them with exceptional electrocatalytic performance.
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http://dx.doi.org/10.1039/d0nr07157aDOI Listing
January 2021

MRI features of responsible contacts in vascular compressive trigeminal neuralgia and prediction modeling.

Acta Radiol 2021 Jan 7:284185120983971. Epub 2021 Jan 7.

Department of Radiology, Fujian Medical University Union Hospital, Fuzhou, PR China.

Background: Multiple neurovascular contacts in patients with vascular compressive trigeminal neuralgia often challenge the diagnosis of responsible contacts.

Purpose: To analyze the magnetic resonance imaging (MRI) features of responsible contacts and establish a predictive model to accurately pinpoint the responsible contacts.

Material And Methods: Sixty-seven patients with unilateral trigeminal neuralgia were enrolled. A total of 153 definite contacts (45 responsible, 108 non-responsible) were analyzed for their MRI characteristics, including neurovascular compression (NVC) grading, distance from pons to contact (D), vascular origin of compressing vessels, diameter of vessel (D) and trigeminal nerve (D) at contact. The MRI characteristics of the responsible and non-responsible contacts were compared, and their diagnostic efficiencies were further evaluated using a receiver operating characteristic (ROC) curve. The significant MRI features were incorporated into the logistics regression analysis to build a predictive model for responsible contacts.

Results: Compared with non-responsible contacts, NVC grading and arterial compression ratio (84.44%) were significantly higher, D was significantly lower at responsible contacts ( < 0.001, 0.002, and 0.033, respectively). NVC grading had a highest diagnostic area under the ROC curve (AUC) of 0.742, with a sensitivity of 64.44% and specificity of 75.00%. The logistic regression model showed a higher diagnostic efficiency, with an AUC of 0.808, sensitivity of 88.89%, and specificity of 62.04%.

Conclusion: Contact degree and position are important MRI features in identifying the responsible contacts of the trigeminal neuralgia. The logistic predictive model based on D, NVC grading, and vascular origin can qualitatively improve the prediction of responsible contacts for radiologists.
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http://dx.doi.org/10.1177/0284185120983971DOI Listing
January 2021

Constructing Atomic Heterometallic Sites in Ultrathin Nickel-Incorporated Cobalt Phosphide Nanosheets via a Boron-Assisted Strategy for Highly Efficient Water Splitting.

Nano Lett 2021 Jan 5;21(1):823-832. Epub 2021 Jan 5.

Center for Clean Energy Technology, School of Mathematical and Physical Science, Faculty of Science, University of Technology Sydney, Sydney, New South Wales 2007, Australia.

Identification of active sites for highly efficient catalysts at the atomic scale for water splitting is still a great challenge. Herein, we fabricate ultrathin nickel-incorporated cobalt phosphide porous nanosheets (Ni-CoP) featuring an atomic heterometallic site (NiCoP) via a boron-assisted method. The presence of boron induces a release-and-oxidation mechanism, resulting in the gradual exfoliation of hydroxide nanosheets. After a subsequent phosphorization process, the resultant Ni-CoP nanosheets are implanted with unsaturated atomic heterometallic NiCoP sites (with Co vacancies) for alkaline hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). The optimized Ni-CoP exhibits a low overpotential of 88 and 290 mV at 10 mA cm for alkaline HER and OER, respectively. This can be attributed to reduced free energy barriers, owing to the direct influence of center Ni atoms to the adjacent Co/P atoms in NiCoP sites. These provide fundamental insights on the correlation between atomic structures and catalytic activity.
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http://dx.doi.org/10.1021/acs.nanolett.0c04569DOI Listing
January 2021

Structure-dependent degradation of nitroimidazoles by cobalt-manganese layered double hydroxide catalyzed peroxymonosulfate process.

Chemosphere 2021 Mar 18;266:129006. Epub 2020 Nov 18.

Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou, 510632, China. Electronic address:

The increasing concentration of nitroimidazoles antibiotics (NIs) in the water environment has great threat to human and ecosystem security. Herein, the degradation rates of four NIs were found to vary with their molecular structures using CoMn-layered double hydroxide (LDH) catalyzed peroxymonosulfate oxidation process. Specifically, the degradation efficiency of secnidazole (SNZ) was determined to be the highest with a reaction rate of 0.24 min, which was 3.6, 2.3 and 1.8 times to that of menidazole (MZ), metronidazole (MTZ) and ornidazole (ONZ), respectively. During the reaction, 8.3% of Co and 8.4% of Mn transformed to Co and Mn after reaction, respectively. The conversion of bimetallic valence in CoMn-LDH donated electrons (e) for PMS activation, resulting in the production of O, OH, SO and O. Density functional theory (DFT) calculation showed that the presence of electron-donating groups (-CH and -OH) and the absence of electron-withdrawing atom (Cl) leaded to the richest active sites in the molecular structure of SNZ, which thus contributed to the highest degradation efficiency of SNZ. By deducing the structure-dependent degradation pathways of four NIs, the carbon chain of SNZ was found to be more easily attacked to form MTZ and MZ because of its unique active sites, resulting in the faster degradation rate of SNZ than MTZ and MZ. This study may provide a valuable insight into the effects of molecular structures on the degradation rates and transformation pathways of NIs.
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http://dx.doi.org/10.1016/j.chemosphere.2020.129006DOI Listing
March 2021

Corrigendum to 'Effects of PM exposure in utero on heart injury, histone acetylation and GATA4 expression in offspring mice'[Chemosphere, 2020, volume 256, 127133].

Chemosphere 2021 Jan 24;262:128679. Epub 2020 Oct 24.

State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong. Electronic address:

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http://dx.doi.org/10.1016/j.chemosphere.2020.128679DOI Listing
January 2021

Retrograde Type A Aortic Dissection after Thoracic Endovascular Aortic Repair: Incidence, Time Trends and Risk Factors.

Semin Thorac Cardiovasc Surg 2020 Nov 9. Epub 2020 Nov 9.

Department of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China; Department of Vascular Surgery, Xiamen Branch, Zhongshan hospital, Fudan University, Xiamen, China; Vascular Surgery Institute of Fudan University, Shanghai, China. Electronic address:

To review the incidence of retrograde type A aortic dissection (RTAD) after thoracic endovascular aortic repair (TEVAR) of patients with type B aortic dissection, and to investigate its time trends and underlying risk factors. The incidence rate of RTAD after TEVAR for type B aortic dissection was gathered as a cumulative pool for each year in meta-analysis. Linear regression was used to establish the temporal trend of RTAD incidence. Annual decrease rate was calculated for the fulltime frame. Sixty-six articles were included in this study, which represented 11,149 patients enrolled since 1994, and the research published between 2000 and 2019. The overall pooled rate of RTAD incidence is 2.20% (95% confidence interval 0.0162-0.0284; P < 0.0001). The incidence numbers fluctuated for many years while continuing to decline, ultimately reaching a valley in 2016-2017. The linear regression analysis identified a 0.4% decrease in incidence rate along with a declining oversize rate of stent-grafts. The overall average incidence of RTAD in the past 21 years was 2.2%. The downward incidence trend may be attributed to the lower oversize rate and the improved design of stent-grafts, as well as sophisticated manipulation and delayed TEVAR intervention.
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http://dx.doi.org/10.1053/j.semtcvs.2020.11.010DOI Listing
November 2020

Recent Progress on Nanostructured Layered Double Hydroxides for Visible-Light-Induced Photoreduction of CO.

Chem Asian J 2020 Nov 6;15(21):3380-3389. Epub 2020 Oct 6.

State Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Centre for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.

Photoreduction of CO into solar fuels is usually regarded as one of the promising solutions to overcome environmental pollution and the energy crisis. The main challenge in CO photoreduction (CO PR) is the low efficiency and poor selectivity. Layered double hydroxides (LDHs) are a class of 2D materials, consisting with M(OH) octahedra in the host layers and intercalated anions. Owing to the tuneable composition, particle size, morphology, and virtue coordinatively unsaturated active sites, a series of efficient strategies (morphology control, heterostructure, defect control, etc.) in LDH-based photocatalysts have been efficiently developed to enhance the photocatalytic selectivity and activity for CO PR. This review summarizes recent progress on the LDH-based photocatalysts for CO PR.
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http://dx.doi.org/10.1002/asia.202000963DOI Listing
November 2020

A pH/ROS cascade-responsive and self-accelerating drug release nanosystem for the targeted treatment of multi-drug-resistant colon cancer.

Drug Deliv 2020 Dec;27(1):1073-1086

Department of Radiation Oncology, Anhui Provincial Cancer Hospital (The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China), Hefei, China.

The efficacy of chemotherapeutic agents for colon cancer treatment is limited by multidrug resistance (MDR) and insufficient intracellular release of the administered nanomedicine. To overcome these limitations, we constructed a pH/ROS cascade-responsive and self-accelerating drug release nanoparticle system (PLP-NPs) for the treatment of multidrug-resistant colon cancer. The PLP-NPs comprised a reactive oxygen species (ROS)-sensitive polymeric paclitaxel (PTX) prodrug (DEX-TK-PTX), a pH-sensitive poly(l-histidine) (PHis), and beta-lapachone (Lapa), a ROS-generating agent. We found that PLP-NPs could accumulate in tumor tissue through enhancement of the permeability and retention (EPR) effect, and were subsequently internalized by cancer cells via the endocytic pathway. Within the acidic endo-lysosomal environment, PHis protonation facilitated the escape of the PLP-NPs from the lysosome and release of Lapa. The released Lapa generated a large amount of ROS, consumed ATP, and downregulated P-glycoprotein (P-gp) production through the activity of NQO1, an enzyme that is specifically overexpressed in tumor cells. In addition, the generated ROS promoted the release of PTX from DEX-TK-PTX to kill cancer cells, while ATP depletion inhibited P-gp-mediated MDR. and experiments subsequently confirmed that PLP-NPs induced tumor-specific cytotoxicity and overcame the MDR of colon cancer. Our findings indicate that the use of the PLP-NPs system represents a promising strategy to counter MDR in the treatment of colon cancer.
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http://dx.doi.org/10.1080/10717544.2020.1797238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470062PMC
December 2020

A Polymorphism at the microRNA Binding Site in the 3' Untranslated Region of Is Associated with Breast Cancer.

DNA Cell Biol 2020 Oct 15;39(10):1886-1894. Epub 2020 Jul 15.

Department of Immunology and Rheumatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, P.R. China.

Single nucleotide polymorphisms in miRNA binding sites (miR-SNPs) are associated with cancer risk. We assessed the relationship between five miR-SNPs in the 3' untranslated region (3'-UTR) of (rs1044129), (rs1053667), (rs4901706), (rs11337), and (rs3660) and the risk of breast cancer (BC). The CC genotype of rs3660 located in the 3'-UTR of was identified for its association with lower BC risk (odds ratio, 0.093; 95% confidence interval, 0.045-0.193;  = 0.000). Immunnochemical analysis and Renilla luciferase reporter assays indicated that the CC genotype of was associated with lower expression of ( < 0.05). The subsequently functional analysis showed that knockdown the could inhibit proliferation and promote apoptosis of the MDA-MB-231 BC cells ( < 0.05) with monocyte chemotactic protein-1 (MCP-1) deregulation. Meanwhile, overexpression could promote the proliferation and inhibit the apoptosis of MCF-7 BC cells ( < 0.05). Our data demonstrated that the expressional change modulated by rs3660 miR-SNP could modify the carcinogenesis of BC, thereby would be a new target for BC treatment.
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http://dx.doi.org/10.1089/dna.2019.5179DOI Listing
October 2020

Antibiotics Modulate Chemotherapy Efficacy in Patients with Esophageal Cancer.

Cancer Manag Res 2020 25;12:4991-4997. Epub 2020 Jun 25.

Department of Immunology and Rheumatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.

Purpose: Accumulating evidence suggests that microbiota dysbiosis induced by antibiotic administration plays a crucial role in regulating the efficacy and toxicity of cancer therapy. We explored the influence of antibiotic administration on the efficacy of chemotherapy in patients with esophageal cancer (EC).

Patients And Methods: EC patients were stratified into two groups: antibiotic-treated group and control group. The antibiotic-treated group included patients who received antibiotics within 60 days before or after chemotherapy initiation, and the control group included patients who did not receive antibiotics within 60 days before or after chemotherapy initiation. Progression-free survival (PFS) and overall survival (OS) curves were constructed using the Kaplan-Meier method. The Cox proportional hazards model was used for univariate and multivariate analyses.

Results: The rate of primary progressive disease in the antibiotic-treated group was significantly higher than that in the control group (36.58% vs 10.45%, = 0.002) as calculated using the chi-square test. Further, antibiotic administration was associated with shorter PFS (6.7 vs 14.6 months, hazard ratio (HR): 2.545, 95% confidence interval (CI): 1.554-4.168, < 0.001) and reduced OS (15.0 vs 21.0 months, HR: 2.007, 95% CI: 1.213-3.319, = 0.007) in univariate analysis. Subsequent multivariate analysis indicated that antibiotic administration was a significant independent prognostic factor for PFS (HR: 2.350, 95% CI: 1.423-3.882, = 0.001) and OS (HR: 1.900, 95% CI: 1.140-3.167, = 0.014).

Conclusion: Antibiotic administration was associated with reduced chemotherapy efficacy and poor prognosis in patients with EC.
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http://dx.doi.org/10.2147/CMAR.S248130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323800PMC
June 2020

Immune-Related Adverse Events Mimicking Behcet's Disease in a Gastric Cancer Patient Following Camrelizumab Treatment.

Iran J Immunol 2020 Jun;17(2):167-171

Department of Surgery,The Fourth Hospital of Hebei Medical University, Shijiazhuang, P.R. China.

Background: Anti-programmed cell death 1(anti-PD-1) antibodies are immune checkpoint inhibitors (ICIs) used as a treatment option for a number of cancers to expand lifespan. However, the toxicity caused by ICIs is often unpredictable and can be occasionally life-threatening.

Objective: To evaluate the immune-related adverse events (irAEs) induced by Camrelizumab, an anti-PD-1 antibody in a patient with gastric cancer.

Case: The patient was a 32-year-old man who was diagnosed with stage IIIA gastric adenocarcinoma (cT4aN1M0) in pre-operative evaluation. However, pancreatic invasion and peritoneal metastasis were found during surgery. He received a three-week cycle of 200 mg Camrelizumab combined with systemic chemotherapy. After the fifth administration of Camrelizumab, the patient displayed irAE mimicking Behcet's disease with oral and penile ulcers, skin and abdominal incision lesions. Camrelizumab was permanently discontinued, but systemic chemotherapy was continued. The symptoms were improved with discontinuation of Camrelizumab and administration of glucocorticoid and immunosuppressive agents for 8 weeks, but suspicious liver metastases occurred and carbohydrate antigen 19-9 showed an increasing trend in the meantime. Given the significant improvement in the patient's symptoms after discontinuation of Camrelizumab and administration of corticosteroids and immunosuppressants, we assumed that these treatments may play a role in the rehabilitation of patients.

Conclusion: Severe irAEs occur at a low frequency when anti-PD-1 antibodies are used as monotherapy. Whether anti-PD-1 antibodies combined with systemic chemotherapy increase the incidence of irAEs is not certain.
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http://dx.doi.org/10.22034/iji.2020.85507.1717DOI Listing
June 2020

Retraction Note to: The role of seed appendage in improving the adaptation of a species in definite seasons: a case study of Atriplex centralasiatica.

BMC Plant Biol 2020 06 15;20(1):276. Epub 2020 Jun 15.

School of Life Sciences, Shaoxing University, Shaoxing, Zhejiang, People's Republic of China.

An amendment to this paper has been published and can be accessed via the original article.
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http://dx.doi.org/10.1186/s12870-020-02482-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296925PMC
June 2020

Effects of PM exposure in utero on heart injury, histone acetylation and GATA4 expression in offspring mice.

Chemosphere 2020 Oct 19;256:127133. Epub 2020 May 19.

State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong SAR, China. Electronic address:

Atmospheric fine particulate matter exposure (PM) can increase the incidence and mortality of heart disease, and raise the risk of fetal congenital heart defect, which have recently drawn much attention. In this study, C57BL/6 mice were exposed to PM (approximately equivalent to 174 μg/m) by intratracheal instillation during the gestation. After birth, 10 weeks old offspring mice were divided into four groups: male exposed group (ME), female exposed group (FE), male control group (MC), female control group (FC). The pathological injury, pro-inflammatory cytokines, histone acetylation levels, and expressions of GATA-binding protein 4 (GATA4) and downstream genes were investigated. The results showed that exposure to PM in utero increased pathological damage and TNF-α and IL-6 levels in hearts of offspring mice, and effects in ME were more serious than FE. Notably, GATA4 protein levels in hearts in ME were significantly lower than that of MC, accompanied by down-regulation of histone acetyltransferase (HAT)-p300 and up-regulation of histone deacetylase-SIRT3. As GATA4 downstream genes, ratios of β-MHC gene expression to α-MHC significantly raised in ME relative to the MC. Results of chromatin immunoprecipitation (ChIP)-qPCR assay found that binding levels of acetylated histone 3 lysine 9 (H3K9ac) in GATA4 promoter region in the hearts of ME or FE were markedly decreased compared with their corresponding control groups. It suggested that maternal exposure to PM may cause cardiac injury in the offspring, heart damage of male mice was worse than female mice, in which process HAT-p300, H3K9ac, transcription factor GATA4 may play an important regulation role.
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http://dx.doi.org/10.1016/j.chemosphere.2020.127133DOI Listing
October 2020

Influence of Phragmites communis and Zizania aquatica on rhizosphere soil enzyme activity and bacterial community structure in a surface flow constructed wetland treating secondary domestic effluent in China.

Environ Sci Pollut Res Int 2020 Jul 1;27(21):26141-26152. Epub 2020 May 1.

Institute of Loess Plateau, Shanxi University, Taiyuan, 030006, China.

The present study aims to investigate the effects of Phragmites communis and Zizania aquatica on rhizosphere soil enzyme activity and bacterial community structure in a surface flow constructed wetland (SFCW) for the treatment of domestic sewage from the Shanxi province of China. The basic physical and chemical properties of the soil, the contents of soil urease (UE), alkaline phosphatase (ALP), soil microbial biomass carbon and nitrogen (SMBC, SMBN), and bacterial community structure were measured in the Phragmites communis group (PG), Zizania aquatica group (ZG), and control group (CG), respectively. The results showed that (1) the contents of UE, ALP, SMBC, and SMBN in rhizosphere soil of PG were more than those of ZG; (2) the highest bacterial abundance and α-diversity appeared in PG, in which Gp6 was the most abundant bacterial genus in PG; (3) the main functions of the dominant bacteria Gp6 and Longilinea in PG were involved in metabolizing multiple carbohydrates and participating in the carbon cycle in the soil based on the clusters of orthologous groups pathway analysis data; (4) the bacterial community of PG was mainly affected by the positive correlation with arsenic, nickel, or SMBC via the redundancy analysis. Collectively, Phragmites communis is a recommended species for wastewater wetland treatment system in Shanxi province, and the special enzymes and dominant bacteria in plant rhizosphere soil had obvious functions of removing organic pollutants. Besides, the influences of environmental factors on rhizosphere bacteria and the combined effects of Phragmites communis and dominant bacteria in wetland wastewater treatment system should be taken seriously.
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http://dx.doi.org/10.1007/s11356-020-08904-zDOI Listing
July 2020

500 nm induced tunable syngas synthesis from CO photoreduction by controlling heterojunction concentration.

Chem Commun (Camb) 2020 May;56(40):5354-5357

State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, P. R. China.

A heterostructured CoAl-layered double hydroxide/MoS2 nanocomposite photocatalyst (CoAl-LDH/MoS2) for CO2 photoreduction was prepared by simple electrostatic interactions. The syngas ratio (H2 : CO) was precisely tuned from 1.3 : 1 to 15 : 1 by altering only the catalyst concentration in the photocatalytic CO2 reduction system under visible light (λ > 400 nm). Interestingly, a rather high evolution rate can be obtained from CO2 photoreduction to CO up to 4575 μmol g-1 h-1 even under irradiation above 500 nm.
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http://dx.doi.org/10.1039/d0cc00971gDOI Listing
May 2020

In vitro high-throughput drug sensitivity screening with patient-derived primary cells as a guide for clinical practice in hepatocellular carcinoma-A retrospective evaluation.

Clin Res Hepatol Gastroenterol 2020 10 31;44(5):699-710. Epub 2020 Jan 31.

Precision Targeted Therapy Discovery Center, Institute of Technology Innovation, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, China.

Aim: The aim of the study was to determine the clinical value of in vitro high-throughput drug sensitivity screening with primary hepatocellular carcinoma cells to select drugs for adjuvant chemotherapy.

Methods: This study included 162 patients who underwent hepatectomy from September 2013 to December 2016. The patients were divided into a drug sensitivity screening group and an empirical treatment group. High-throughput drug sensitivity screening using primary HCC cells was carried out and, based on the test results, effective drugs were selected for treatment. Patients in the empirical group were treated with commonly used drugs, according to the clinicians' preferences. Clinical efficacy, i.e., disease-free survival (DFS) time, was compared between the two groups.

Results: Most patients with HCC showed extensive resistance to known chemotherapeutic drugs. However, bortezomib, regorafenib, sorafenib, romidepsin, hydroxycamptothecin and adriamycin+oxaliplatin showed strong anti-HCC activity in the sensitivity assay. Comparing clinical efficacy, the overall median DFS of patients in the drug sensitivity screening group was significantly better than that of patients in the empirical treatment group (17.00±3.80 months vs. 9.00±1.18 months, P=0.001). Median DFS times in the TACE group were 9.00±4.07 months vs. 7.00±1.06 months (P=0.014) and median DFS times in the oral drugs group were 16.80±3.98 months vs. 10.00±0.81 months (P=0.024). Patients DFS was 69.4%, 62.5% at 1-, 2- years, respectively, for patients with drug sensitivity screening, and 48.5%, 37.8% at 1-, 2- years, respectively, for patients with empirical treatment.

Conclusion: High-throughput drug sensitivity screening can be successfully used to screen chemotherapeutic drugs for efficacy against HCC and the efficacious drugs can be used in postoperative adjuvant chemotherapy of HCC patients. This treatment paradigm is safe and reliable, and improves survival compared with empirical chemotherapy.
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http://dx.doi.org/10.1016/j.clinre.2020.01.003DOI Listing
October 2020

Tuning the Coordination Environment in Single-Atom Catalysts to Achieve Highly Efficient Oxygen Reduction Reactions.

J Am Chem Soc 2019 Dec 17;141(51):20118-20126. Epub 2019 Dec 17.

Center for Clean Energy Technology, School of Mathematical and Physical Sciences, Faculty of Science , University of Technology Sydney , Ultimo , New South Wales 2007 , Australia.

Designing atomically dispersed metal catalysts for oxygen reduction reaction (ORR) is a promising approach to achieve efficient energy conversion. Herein, we develop a template-assisted method to synthesize a series of single metal atoms anchored on porous N,S-codoped carbon (NSC) matrix as highly efficient ORR catalysts to investigate the correlation between the structure and their catalytic performance. The structure analysis indicates that an identical synthesis method results in distinguished structural differences between Fe-centered single-atom catalyst (Fe-SAs/NSC) and Co-centered/Ni-centered single-atom catalysts (Co-SAs/NSC and Ni-SAs/NSC) because of the different trends of each metal ion in forming a complex with the N,S-containing precursor during the initial synthesis process. The Fe-SAs/NSC mainly consists of a well-dispersed FeNS center site where S atoms form bonds with the N atoms. The S atoms in Co-SAs/NSC and Ni-SAs/NSC, on the other hand, form metal-S bonds, resulting in CoNS and NiNS center sites. Density functional theory (DFT) reveals that the FeNS center site is more active than the CoNS and NiNS sites, due to the higher charge density, lower energy barriers of the intermediates, and products involved. The experimental results indicate that all three single-atom catalysts could contribute high ORR electrochemical performances, while Fe-SAs/NSC exhibits the highest of all, which is even better than commercial Pt/C. Furthermore, Fe-SAs/NSC also displays high methanol tolerance as compared to commercial Pt/C and high stability up to 5000 cycles. This work provides insights into the rational design of the definitive structure of single-atom catalysts with tunable electrocatalytic activities for efficient energy conversion.
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http://dx.doi.org/10.1021/jacs.9b09352DOI Listing
December 2019

The role of seed appendage in improving the adaptation of a species in definite seasons: a case study of Atriplex centralasiatica.

BMC Plant Biol 2019 Dec 4;19(1):538. Epub 2019 Dec 4.

School of Life Sciences, Shaoxing University, Shaoxing, Zhejiang, People's Republic of China.

Background: As a common accompanying dispersal structure, specialized seed appendages play a critical role in the successful germination and dispersal of many plants, and are regarded as an adaptation character for plants survival in diverse environments. However, little is known about how the appendages modulate the linkage between germination and environmental factors. Here, we tested the responses of germination to seasonal environmental signals (temperature and humidity) via seed appendages using Atriplex centralasiatica, which is widely distributed in salt marshlands with dry-cold winter in northern China. Three types of heteromorphic diaspores that differ in morphology of persistent bracteole and dormancy levels are produced in an individual plant of A. centralasiatica.

Results: Except for the nondormant diaspore (type A, with a brown seed enclosed in a persistent bracteole), bracteoles regulated inner seed dormancy of the other two dormant diaspore types, i.e., type B (flat diaspore with a black inner seed) and type C (globular diaspore with a black inner seed). For types B and C, germination of bracteole-free seeds was higher than that of intact diaspores, and was limited severely when incubated in the bracteole-soaking solution. Dormancy was released at a low temperature (< 10 °C) and suitable humidity (5-15%) condition. Oppositely, high temperature and unfit humidity induced secondary dormancy via inhibitors released by bracteoles. Type C with deeper dormancy needed more stringent conditions for dormancy release and was easier for dormancy inducement than type B. The germination windows were broadened and the time needed for dormancy release decreased after the bracteole flushing for the two dormant types in the field condition.

Conclusions: Bracteoles determine the germination adaptation by bridging seeds and environmental signals and promising seedlings establishment only in proper seasons, which may also restrict species geographical distribution and shift species distributing ranges under the global climate change scenarios.
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http://dx.doi.org/10.1186/s12870-019-2090-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894244PMC
December 2019
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