Publications by authors named "Yuehan Wang"

10 Publications

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Does Endometriosis Disturb Mental Health and Quality of Life? A Systematic Review and Meta-Analysis.

Gynecol Obstet Invest 2021 Aug 5:1-21. Epub 2021 Aug 5.

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.

Introduction: This study aimed to evaluate whether endometriosis could disturb the mental health and health-related quality of life (HRQoL) of patients and to provide a new prospective for further treatment of endometriosis.

Methods: A comprehensive literature review was conducted among 4 international databases (PubMed, Embase, Web of Science, and Cochrane Library) and 2 of the largest Chinese databases (the China National Knowledge Infrastructure and Wangfang). The Newcastle-Ottawa Scale was used to assess the quality of the included articles. Six effect sizes were synthesized through a meta-analysis, and a subgroup analysis was performed to identify potential moderating factors, including types of control groups, methods of assessment, number of study groups, and origin of the study. Potential publication bias was examined using a funnel plot.

Results: This meta-analysis pooled 44 articles from 4 continents and 13 countries and compared 6 types of main effect sizes (the odds ratio [OR] for depression, the OR for anxiety, the standardized mean difference [SMD] for depression, the SMD for anxiety, the SMD for the physical component summary [PCS] and the SMD for the mental component summary [MCS]) between endometriosis patients and controls. Except for the SMD for depression, all other effect sizes revealed statistically significant differences between the study group and the controls. The main effect size outcomes of the subgroup analysis were also similar. The type of control group (I2 = 35% in non-endometriosis control groups for the SMD of anxiety; I2 = 47% in non-endometriosis control groups for the MCS of the 36-Item Short Form Health Survey) and the continent of origin (I2 = 0% in studies from South America for the OR of depression; I2 = 47% in studies from Europe for the SMD of anxiety) may influence heterogeneity in this analysis. Additionally, depression and anxiety symptoms in patients seemed to be more apparent compared with healthy controls when the sample was smaller and when a questionnaire was used. The publication bias of the articles was acceptable.

Conclusion: Endometriosis can disturb mental health (specifically depression and anxiety) and decrease both the mental and physical HRQoL of patients. There may be some moderating factors that we were unable to identify in the subgroup analysis, but more research is necessary to develop proper management and improve the prognosis of endometriosis patients.
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http://dx.doi.org/10.1159/000516517DOI Listing
August 2021

Investigation of the Mechanism of Complement System in Diabetic Nephropathy via Bioinformatics Analysis.

J Diabetes Res 2021 24;2021:5546199. Epub 2021 May 24.

Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072 Sichuan, China.

Objectives: Diabetic nephropathy (DN) is a major cause of end-stage renal disease (ESRD) throughout the world, and the identification of novel biomarkers via bioinformatics analysis could provide research foundation for future experimental verification and large-group cohort in DN models and patients.

Methods: GSE30528, GSE47183, and GSE104948 were downloaded from Gene Expression Omnibus (GEO) database to find differentially expressed genes (DEGs). The difference of gene expression between normal renal tissues and DN renal tissues was firstly screened by GEO2R. Then, the protein-protein interactions (PPIs) of DEGs were performed by STRING database, the result was integrated and visualized via applying Cytoscape software, and the hub genes in this PPI network were selected by MCODE and topological analysis. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were carried out to determine the molecular mechanisms of DEGs involved in the progression of DN. Finally, the Nephroseq v5 online platform was used to explore the correlation between hub genes and clinical features of DN.

Results: There were 64 DEGs, and 32 hub genes were identified, enriched pathways of hub genes involved in several functions and expression pathways, such as complement binding, extracellular matrix structural constituent, complement cascade related pathways, and ECM proteoglycans. The correlation analysis and subgroup analysis of 7 complement cascade-related hub genes and the clinical characteristics of DN showed that C1QA, C1QB, C3, CFB, ITGB2, VSIG4, and CLU may participate in the development of DN.

Conclusions: We confirmed that the complement cascade-related hub genes may be the novel biomarkers for DN early diagnosis and targeted treatment.
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http://dx.doi.org/10.1155/2021/5546199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169258PMC
May 2021

Guidance regarding COVID-19 for survivors of childhood, adolescent, and young adult cancer: A statement from the International Late Effects of Childhood Cancer Guideline Harmonization Group.

Pediatr Blood Cancer 2020 12 23;67(12):e28702. Epub 2020 Sep 23.

Department of Malignant Haematology, Great Ormond Street Hospital for Children NHS Trust, London, UK.

Childhood, adolescent, and young adult (CAYA) cancer survivors may be at risk for a severe course of COVID-19. Little is known about the clinical course of COVID-19 in CAYA cancer survivors, or if additional preventive measures are warranted. We established a working group within the International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG) to summarize existing evidence and worldwide recommendations regarding evidence about factors/conditions associated with risk for a severe course of COVID-19 in CAYA cancer survivors, and to develop a consensus statement to provide guidance for healthcare practitioners and CAYA cancer survivors regarding COVID-19.
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http://dx.doi.org/10.1002/pbc.28702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537044PMC
December 2020

Multitask Learning and GCN-Based Taxi Demand Prediction for a Traffic Road Network.

Sensors (Basel) 2020 Jul 5;20(13). Epub 2020 Jul 5.

School of Information Engineering, Chang'an University, Xi'an 710064, China.

The accurate forecasting of urban taxi demands, which is a hot topic in intelligent transportation research, is challenging due to the complicated spatial-temporal dependencies, the dynamic nature, and the uncertainty of traffic. To make full use of the global and local correlations between traffic flows on road sections, this paper presents a deep learning model based on a graph convolutional network, long short-term memory (LSTM), and multitask learning. First, an undirected graph model was formed by considering the spatial pattern distribution of taxi trips on road networks. Then, LSTMs were used to extract the temporal features of traffic flows. Finally, the model was trained using a multitask learning strategy to improve the model's generalizability. In the experiments, the efficiency and accuracy were verified with real-world taxi trajectory data. The experimental results showed that the model could effectively forecast the short-term taxi demands on the traffic network level and outperform state-of-the-art traffic prediction methods.
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http://dx.doi.org/10.3390/s20133776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374365PMC
July 2020

Cutaneous metastasis of renal cell carcinoma.

Lancet Oncol 2020 05;21(5):e292

Department of Urology, Singapore General Hospital, Singapore.

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http://dx.doi.org/10.1016/S1470-2045(20)30143-1DOI Listing
May 2020

Strategies to Improve the Outcome of Cryoballoon Ablation in the Treatment of Atrial Fibrillation.

Biomed Res Int 2020 6;2020:6720481. Epub 2020 Apr 6.

The First Academy of Clinical Medical, Anhui Medical University, Hefei 230032, China.

Atrial fibrillation (AF) is a common arrhythmia contributing to severe outcomes, including cardiac dysfunction and stroke, and it has drawn great attention around the world. Drug therapies have been available for many years to terminate AF and control heart rate. However, the results from clinical studies on drug therapies have been discouraging. Mounting evidence indicates that radiofrequency catheter ablation (RFCA) is a safe and effective method to maintain sinus rhythm, especially in patients who are drug intolerant or for whom the drugs are ineffective, although it is a technically demanding and complex procedure. Fortunately, a novel application, cryoballoon ablation (CBA), with outstanding characteristics has been widely used. Great outcomes based on CBA have manifested its significant role in the treatment of AF. However, how to improve the safety and efficacy of CBA is a question that has not been well-answered. Would it be helpful to develop a different generation of cryoballoon? Is bonus freezing beneficial, or not? Is it better to prolong freezing time? Dose CBA combined with RFCA bring higher success rates? In this review, we comprehensively summarized useful applications for improving outcomes of CBA in AF patients.
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http://dx.doi.org/10.1155/2020/6720481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166274PMC
January 2021

Minimally invasive surgery for uterine fibroids.

Ginekol Pol 2020 ;91(3):149-157

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.

The incidence of uterine fibroids, which comprise one of the most common female pelvic tumors, is almost 70-75% for women of reproductive age. With the development of surgical techniques and skills, more individuals prefer minimally invasive methods to treat uterine fibroids. There is no doubt that minimally invasive surgery has broad use for uterine fibroids. Since laparoscopic myomectomy was first performed in 1979, more methods have been used for uterine fibroids, such as laparoscopic hysterectomy, laparoscopic radiofrequency volumetric thermal ablation, and uterine artery embolization, and each has many variations. In this review, we compared these methods of minimally invasive surgery for uterine fibroids, analyzed their benefits and drawbacks, and discussed their future development.
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http://dx.doi.org/10.5603/GP.2020.0032DOI Listing
August 2021

Leisure-Time Running Reduces the Risk of Incident Type 2 Diabetes.

Am J Med 2019 10 17;132(10):1225-1232. Epub 2019 May 17.

Department of Exercise Science, University of South Carolina, Columbia, SC.

Objectives: We examined the overall association as well as the dose-response relationship between leisure-time running and incident type 2 diabetes.

Methods: Participants were 19,347 adults aged 18-100 years who were free of cardiovascular disease, cancer, and diabetes at baseline, and who received at least 2 extensive preventive medical examinations between 1974 and 2006. Running and other types of aerobic physical activity were assessed by self-reported leisure-time activities. Type 2 diabetes was defined as fasting glucose ≥126 mg/dL (7.0 mmol/L), physician diagnosis, or insulin use.

Results: During an average follow-up of 6.5 years, 1015 adults developed type 2 diabetes. Approximately 29.5% of adults participated in leisure-time running at baseline. Runners had a 28% (hazard ratio [HR] 0.72; 95% confidence interval [CI], 0.62-0.84) lower risk of developing type 2 diabetes compared with nonrunners during follow-up. The HRs (95% CIs) of type 2 diabetes were 0.98 (0.75-1.28), 0.69 (0.51-0.92), 0.62 (0.45-0.85), 0.78 (0.59-1.04), and 0.57 (0.42-0.79) across quintiles of running time (minutes/week) compared with nonrunners after adjusting for potential confounders, including levels of nonrunning aerobic physical activity. Similar dose-response relationships between running distance (miles/week), frequency (times/week), total amount (MET-minutes/week), and speed (mph) were also observed.

Conclusions: Participating in leisure-time running is associated with a lower risk of developing type 2 diabetes in adults. Consistent linear dose-response relationships were observed between various running parameters and incident type 2 diabetes, supporting the prescription of running to prevent type 2 diabetes.
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http://dx.doi.org/10.1016/j.amjmed.2019.04.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832784PMC
October 2019

Association of Muscular Strength and Incidence of Type 2 Diabetes.

Mayo Clin Proc 2019 04 11;94(4):643-651. Epub 2019 Mar 11.

Department of Exercise Science, University of South Carolina, Columbia, SC.

Objective: To examine the association between muscular strength and incident type 2 diabetes, independent of cardiorespiratory fitness (CRF).

Patients And Methods: A total of 4681 adults aged 20 to 100 years who had no type 2 diabetes at baseline were included in the current prospective cohort study. Participants underwent muscular strength tests and maximal treadmill exercise tests between January 1, 1981, and December 31, 2006. Muscular strength was measured by leg and bench press and categorized as age group- and sex-specific thirds (lower, middle, and upper) of the combined strength score. Type 2 diabetes was defined on the basis of fasting plasma glucose levels, insulin therapy, or physician diagnoses.

Results: During a mean follow-up of 8.3 years, 229 of the 4681 patients (4.9%) had development of type 2 diabetes. Participants with the middle level of muscular strength had a 32% lower risk of development of type 2 diabetes (hazard ratio, 0.68; 95% confidence interval, 0.49-0.94; P=.02) compared with those with the lower level of muscular strength after adjusting for potential confounders, including estimated CRF. However, no significant association between the upper level of muscular strength and incident type 2 diabetes was observed.

Conclusion: A moderate level of muscular strength is associated with a lower risk of type 2 diabetes, independent of estimated CRF. More studies on the dose-response relationship between muscular strength and type 2 diabetes are needed.
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http://dx.doi.org/10.1016/j.mayocp.2018.08.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450733PMC
April 2019

The new evidence on cryoballoon ablation to persistent atrial fibrillation.

Int J Cardiol 2018 11;271:121

Department of Cardiology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2018.05.088DOI Listing
November 2018
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