Publications by authors named "Yue-Ming Li"

100Publications

A Pentacyclic Triterpene from Targets γ-Secretase.

ACS Chem Neurosci 2020 Sep 3;11(18):2827-2835. Epub 2020 Sep 3.

Division of Life Science, State Key Laboratory of Molecular Neuroscience, and Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay Road, Kowloon, Hong Kong, China.

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http://dx.doi.org/10.1021/acschemneuro.0c00389DOI Listing
September 2020

Dolutegravir derivative inhibits proliferation and induces apoptosis of non-small cell lung cancer cells via calcium signaling pathway.

Pharmacol Res 2020 Aug 9;161:105129. Epub 2020 Aug 9.

State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau (SAR), China. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2020.105129DOI Listing
August 2020

Direct Intramolecular Aminoboration of Allenes.

Org Lett 2020 Jul 19;22(13):5090-5093. Epub 2020 Jun 19.

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, 38 Tongyan Road, Tianjin 300353, People's Republic of China.

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http://dx.doi.org/10.1021/acs.orglett.0c01685DOI Listing
July 2020

γ-Secretase Partitioning into Lipid Bilayers Remodels Membrane Microdomains after Direct Insertion.

Langmuir 2020 06 4;36(23):6569-6579. Epub 2020 Jun 4.

Chemical Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, United States.

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http://dx.doi.org/10.1021/acs.langmuir.0c01178DOI Listing
June 2020

γ-Secretase inhibitors and modulators: Mechanistic insights into the function and regulation of γ-Secretase.

Semin Cell Dev Biol 2020 Sep 2;105:43-53. Epub 2020 Apr 2.

Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Pharmacology program, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2020.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483676PMC
September 2020

Substrate interaction inhibits γ-secretase production of amyloid-β peptides.

Chem Commun (Camb) 2020 Feb;56(17):2578-2581

Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA. and Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY 12180, USA and Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.

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http://dx.doi.org/10.1039/c9cc09170jDOI Listing
February 2020

Friend, Foe or Both? Immune Activity in Alzheimer's Disease.

Front Aging Neurosci 2019 10;11:337. Epub 2019 Dec 10.

Chemical Biology Program, Memorial Sloan Kettering Cancer Center, Manhattan, NY, United States.

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http://dx.doi.org/10.3389/fnagi.2019.00337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916654PMC
December 2019

Epac1 inhibition ameliorates pathological angiogenesis through coordinated activation of Notch and suppression of VEGF signaling.

Sci Adv 2020 01 1;6(1):eaay3566. Epub 2020 Jan 1.

Department of Integrative Biology and Pharmacology, University of Texas Health Science Center, Houston, TX, USA.

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http://dx.doi.org/10.1126/sciadv.aay3566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938696PMC
January 2020

Iodine-mediated aminosulfonylation of alkenyl sulfonamides with sulfonyl hydrazides: synthesis of sulfonylmethyl piperidines, pyrrolidines and pyrazolines.

Org Biomol Chem 2019 10 2;17(40):9026-9038. Epub 2019 Oct 2.

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, People's Republic of China. and CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People's Republic of China.

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http://dx.doi.org/10.1039/c9ob01847fDOI Listing
October 2019

Pd-Catalyzed decarboxylative cross-coupling reactions of epoxides with α,β-unsaturated carboxylic acids.

Chem Commun (Camb) 2019 Sep 29;55(74):11123-11126. Epub 2019 Aug 29.

School of Materials and Chemical Engineering, ChuZhou University, Chu Zhou, 239000, China.

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http://dx.doi.org/10.1039/c9cc04795fDOI Listing
September 2019

GSAP modulates γ-secretase specificity by inducing conformational change in PS1.

Proc Natl Acad Sci U S A 2019 03 8;116(13):6385-6390. Epub 2019 Mar 8.

Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10065;

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http://dx.doi.org/10.1073/pnas.1820160116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442608PMC
March 2019

Expression Profiling of Notch Signalling Pathway and Gamma-Secretase Activity in the Brain of Ts1Cje Mouse Model of Down Syndrome.

J Mol Neurosci 2019 Apr 13;67(4):632-642. Epub 2019 Feb 13.

Genetics & Regenerative Medicine Research Centre (GRMRC), Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.

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http://dx.doi.org/10.1007/s12031-019-01275-2DOI Listing
April 2019

Metal-free oxysulfonylation and aminosulfonylation of alkenyl oximes: synthesis of sulfonylated isoxazolines and cyclic nitrones.

Org Biomol Chem 2019 01;17(4):898-907

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, People's Republic of China.

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http://dx.doi.org/10.1039/c8ob02879fDOI Listing
January 2019

Construction of 3,4-Dihydroisoquinolinones and Indanones via DTBP-Promoted Oxidative Coupling of N-Allylbenzamides with Aromatic Aldehydes.

J Org Chem 2018 09 23;83(17):9718-9728. Epub 2018 Aug 23.

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research , Nankai University , Tianjin , People's Republic of China.

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http://dx.doi.org/10.1021/acs.joc.8b01242DOI Listing
September 2018

Mn(OAc)-Mediated Hydrotrifluoromethylation of Unactivated Alkenes Using CFSONa as the Trifluoromethyl Source.

J Org Chem 2018 06 11;83(11):6015-6024. Epub 2018 May 11.

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research , Nankai University , Tianjin , People's Republic of China.

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http://dx.doi.org/10.1021/acs.joc.8b00633DOI Listing
June 2018

The role of astrocytes in amyloid production and Alzheimer's disease.

Open Biol 2017 12;7(12)

Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1098/rsob.170228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746550PMC
December 2017

Versatility of presenilin 1.

Proc Natl Acad Sci U S A 2017 07 23;114(27):6885-6887. Epub 2017 Jun 23.

Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065;

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http://dx.doi.org/10.1073/pnas.1707809114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502655PMC
July 2017

Intramolecular Aminoalkoxylation of Unfunctionalized Olefins via Intramolecular Iodoamination and Aziridinium Ion Ring-Opening Sequence.

Org Lett 2017 04 23;19(7):1520-1523. Epub 2017 Mar 23.

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University , Tianjin 300071, People's Republic of China.

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http://dx.doi.org/10.1021/acs.orglett.7b00284DOI Listing
April 2017

Structural and Chemical Biology of Presenilin Complexes.

Cold Spring Harb Perspect Med 2017 Dec 1;7(12). Epub 2017 Dec 1.

Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrookes Hospital, Cambridge CB2 0XY, United Kingdom.

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http://dx.doi.org/10.1101/cshperspect.a024067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710098PMC
December 2017

Phase Composition Control in Microsphere-Supported Biomembrane Systems.

Langmuir 2017 03 14;33(12):3028-3039. Epub 2017 Mar 14.

Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center , 1275 York Avenue, New York, New York 10065, United States.

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http://dx.doi.org/10.1021/acs.langmuir.6b04150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568755PMC
March 2017

Mapping the Binding Site of BMS-708163 on γ-Secretase with Cleavable Photoprobes.

Cell Chem Biol 2017 Jan 5;24(1):3-8. Epub 2017 Jan 5.

Chemical Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA; Xiangya International Academy of Translational Medicine, Central South University, Changsha, Hunan 410013, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24519456163044
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http://dx.doi.org/10.1016/j.chembiol.2016.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516958PMC
January 2017

Development of Sulfonamide Photoaffinity Inhibitors for Probing Cellular γ-Secretase.

ACS Chem Neurosci 2016 08 17;7(8):1166-73. Epub 2016 Jun 17.

Chemical Biology Program, Memorial Sloan Kettering Cancer Center , 1275 York Avenue, New York, New York 10065, United States.

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http://dx.doi.org/10.1021/acschemneuro.6b00127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576034PMC
August 2016

Preparation of trans-2-Substituted-4-halopiperidines and cis-2-Substituted-4-halotetrahydropyrans via AlCl3-Catalyzed Prins Reaction.

J Org Chem 2016 06 7;81(12):5144-61. Epub 2016 Jun 7.

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University , Tianjin 300071, People's Republic of China.

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http://dx.doi.org/10.1021/acs.joc.6b00725DOI Listing
June 2016

Physiological and pathological roles of the γ-secretase complex.

Brain Res Bull 2016 09 28;126(Pt 2):199-206. Epub 2016 Apr 28.

Chemical Biology Program, Memorial Sloan Kettering Cancer Center, NY, United States; Program of Neuroscience, Weill Graduate School of Medical Sciences of Cornell University, NY, United States; Program of Pharmacology, Weill Graduate School of Medical Sciences of Cornell University, NY, United States.

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http://dx.doi.org/10.1016/j.brainresbull.2016.04.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436903PMC
September 2016

Benzimidazole covalent probes and the gastric H(+)/K(+)-ATPase as a model system for protein labeling in a copper-free setting.

Mol Biosyst 2016 05;12(6):1772-80

Chemical Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA. and Program of Pharmacology, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA.

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http://dx.doi.org/10.1039/c6mb00024jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879604PMC
May 2016

Evidence That the "Lid" Domain of Nicastrin Is Not Essential for Regulating γ-Secretase Activity.

J Biol Chem 2016 Mar 17;291(13):6748-53. Epub 2016 Feb 17.

From the Department of Neurobiology, The University of Chicago, Chicago, Illinois 60637 and

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http://dx.doi.org/10.1074/jbc.C115.701649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807262PMC
March 2016

Imaging and Functional Analysis of γ-Secretase and Substrate in a Proteolipobead System with an Activity-Based Probe.

Anal Chem 2016 Jan 6;88(2):1303-11. Epub 2016 Jan 6.

Chemistry Biology Program, Memorial Sloan-Kettering Cancer Center , 1275 York Avenue, New York, New York 10065, United States.

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http://dx.doi.org/10.1021/acs.analchem.5b03762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911041PMC
January 2016

Modular Preparation of 5-Halomethyl-2-oxazolines via PhI(OAc)2-Promoted Intramolecular Halooxygenation of N-Allylcarboxamides.

J Org Chem 2015 Nov 6;80(22):11339-50. Epub 2015 Nov 6.

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University , Tianjin 300071, People's Republic of China.

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http://dx.doi.org/10.1021/acs.joc.5b01832DOI Listing
November 2015

Intramolecular Aminoboration of Unfunctionalized Olefins.

Angew Chem Int Ed Engl 2015 Oct 1;54(43):12636-9. Epub 2015 Sep 1.

Stake Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071 (P.R. China).

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http://dx.doi.org/10.1002/anie.201505489DOI Listing
October 2015

γ-Secretase Inhibitors and Modulators Induce Distinct Conformational Changes in the Active Sites of γ-Secretase and Signal Peptide Peptidase.

ACS Chem Biol 2015 Aug 10;10(8):1925-31. Epub 2015 Jun 10.

†Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, United States.

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http://dx.doi.org/10.1021/acschembio.5b00321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436900PMC
August 2015

Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH.

Proc Natl Acad Sci U S A 2015 Mar 2;112(11):3344-9. Epub 2015 Mar 2.

Ministry of Education Key Laboratory of Protein Science, Tsinghua-Peking Joint Center for Life Sciences, Center for Structural Biology, and

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http://dx.doi.org/10.1073/pnas.1502150112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371958PMC
March 2015

Complex regulation of γ-secretase: from obligatory to modulatory subunits.

Front Aging Neurosci 2014 6;6:342. Epub 2015 Jan 6.

Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center New York, NY, USA ; Program of Pharmacology, Weill Graduate School of Medical Sciences of Cornell University New York, NY, USA.

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http://dx.doi.org/10.3389/fnagi.2014.00342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285130PMC
January 2015

Regioselective (diacetoxyiodo)benzene-promoted halocyclization of unfunctionalized olefins.

J Org Chem 2014 Nov 20;79(21):10094-109. Epub 2014 Oct 20.

College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University , Tianjin 300071, People's Republic of China.

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http://pubs.acs.org/doi/10.1021/jo501739j
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http://dx.doi.org/10.1021/jo501739jDOI Listing
November 2014

Nontranscriptional role of Hif-1α in activation of γ-secretase and notch signaling in breast cancer.

Cell Rep 2014 Aug 14;8(4):1077-92. Epub 2014 Aug 14.

Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA; Program of Pharmacology, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.07.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346175PMC
August 2014

Development of CBAP-BPyne, a probe for γ-secretase and presenilinase.

Medchemcomm 2014 Mar;5(3):338-341

Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1039/C3MD00281KDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048150PMC
March 2014

Chemical synthesis of the ATAD2 bromodomain.

Proc Natl Acad Sci U S A 2014 Feb 10;111(8):2891-6. Epub 2014 Feb 10.

Bioorganic Chemistry Laboratory, Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065.

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http://dx.doi.org/10.1073/pnas.1400556111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939912PMC
February 2014

Familial Alzheimer's mutations within APPTM increase Aβ42 production by enhancing accessibility of ε-cleavage site.

Nat Commun 2014 ;5:3037

Department of Biological Sciences, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 8th Street, Troy, New York 12180, USA.

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http://dx.doi.org/10.1038/ncomms4037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082030PMC
November 2015

PRSS1_p.Leu81Met mutation results in autoimmune pancreatitis.

World J Gastroenterol 2013 Jun;19(21):3332-8

Department of Pathology, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China.

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http://dx.doi.org/10.3748/wjg.v19.i21.3332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671086PMC
June 2013

Development and mechanism of γ-secretase modulators for Alzheimer's disease.

Biochemistry 2013 May 2;52(19):3197-216. Epub 2013 May 2.

Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center , 1275 York Avenue, New York, New York 10065, United States.

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http://dx.doi.org/10.1021/bi400377pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796170PMC
May 2013

A novel high throughput 1536-well Notch1 γ -secretase AlphaLISA assay.

Comb Chem High Throughput Screen 2013 Jul;16(6):415-24

Memorial Sloan-Kettering Cancer Center, 1275 York Ave., New York, NY 10065, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664143PMC
http://dx.doi.org/10.2174/1386207311316060001DOI Listing
July 2013

BMS-708,163 targets presenilin and lacks notch-sparing activity.

Biochemistry 2012 Sep 4;51(37):7209-11. Epub 2012 Sep 4.

Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, United States.

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http://pubs.acs.org/doi/10.1021/bi301137h
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http://dx.doi.org/10.1021/bi301137hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470910PMC
September 2012

Familial Alzheimer disease presenilin-1 mutations alter the active site conformation of γ-secretase.

J Biol Chem 2012 May 29;287(21):17288-96. Epub 2012 Mar 29.

Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1074/jbc.M111.300483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366784PMC
May 2012

Development of clickable active site-directed photoaffinity probes for γ-secretase.

Bioorg Med Chem Lett 2012 Apr 20;22(8):2997-3000. Epub 2012 Feb 20.

Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.bmcl.2012.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321063PMC
April 2012

Piperidine acetic acid based γ-secretase modulators directly bind to Presenilin-1.

ACS Chem Neurosci 2011 Dec;2(12):705-710

Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1021/cn200098pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249837PMC
December 2011

(Z)-N-{3-[(2-Chloro-1,3-thia-zol-5-yl)meth-yl]-1,3-thia-zolidin-2-yl-idene}cyanamide.

Acta Crystallogr Sect E Struct Rep Online 2011 Dec 12;67(Pt 12):o3303. Epub 2011 Nov 12.

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http://dx.doi.org/10.1107/S1600536811047404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238956PMC
December 2011

Increased expression of PS1 is sufficient to elevate the level and activity of γ-secretase in vivo.

PLoS One 2011 29;6(11):e28179. Epub 2011 Nov 29.

Department of Pathology, The Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0028179PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226664PMC
April 2012

Target of γ-secretase modulators, presenilin marks the spot.

EMBO J 2011 Nov 30;30(23):4696-8. Epub 2011 Nov 30.

Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1038/emboj.2011.410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242977PMC
November 2011

Activation and intrinsic gamma-secretase activity of presenilin 1.

Proc Natl Acad Sci U S A 2010 Dec 29;107(50):21435-40. Epub 2010 Nov 29.

Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065.

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http://dx.doi.org/10.1073/pnas.1013246107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003001PMC
December 2010

Notch dimerization is required for leukemogenesis and T-cell development.

Genes Dev 2010 Nov 8;24(21):2395-407. Epub 2010 Oct 8.

Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1101/gad.1975210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964750PMC
November 2010

In-vitro seeding of human umbilical cord vein endothelial cells on hydroxyapatite for mechanical heart valve applications.

J Heart Valve Dis 2010 Jul;19(4):506-12

Department of Cardiac Surgery, Affiliated Provincial Hospital of Anhui Medical University, Hefei, China.

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July 2010

[Expression characteristics of hypoxia inducible factor-1a and its clinical values in hepatocellular carcinoma].

Zhonghua Gan Zang Bing Za Zhi 2010 Jul;18(7):506-10

Affiliated Hospital of Nantong University, Nantong 226001, China.

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http://dx.doi.org/10.3760/cma.j.issn.1007-3418.2010.07.009DOI Listing
July 2010

Dual role of alpha-secretase cleavage in the regulation of gamma-secretase activity for amyloid production.

J Biol Chem 2010 Oct 30;285(42):32549-56. Epub 2010 Jul 30.

Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1074/jbc.M110.128439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952257PMC
October 2010

In vivo manifestation of Notch related phenotypes in zebrafish treated with Alzheimer's amyloid reducing gamma-secretase inhibitors.

J Neurochem 2010 Jun 12;113(5):1200-9. Epub 2010 Mar 12.

Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2010.06681.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539131PMC
June 2010

Characterization of an atypical gamma-secretase complex from hematopoietic origin.

Biochemistry 2010 Apr;49(13):2796-804

Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1021/bi901388tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880330PMC
April 2010

An APP inhibitory domain containing the Flemish mutation residue modulates gamma-secretase activity for Abeta production.

Nat Struct Mol Biol 2010 Feb 10;17(2):151-8. Epub 2010 Jan 10.

Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1038/nsmb.1743DOI Listing
February 2010

Modulation of gamma-secretase specificity using small molecule allosteric inhibitors.

Proc Natl Acad Sci U S A 2009 Dec 11;106(48):20228-33. Epub 2009 Nov 11.

Molecular Pharmacology and Chemistry Program and High Throughput Screening Core Facility, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1073/pnas.0910757106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787169PMC
December 2009

The processing of human rhomboid intramembrane serine protease RHBDL2 is required for its proteolytic activity.

J Mol Biol 2009 Dec 20;394(5):815-25. Epub 2009 Oct 20.

Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.jmb.2009.10.025DOI Listing
December 2009

Characteristics of hepatic nuclear-transcription factor-kappa B expression and quantitative analysis in rat hepatocarcinogenesis.

Hepatobiliary Pancreat Dis Int 2009 Oct;8(5):504-9

Research Center of Clinical Molecular Biology, Affiliated Hospital of Nantong University, Nantong 226001, China.

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October 2009

A miniaturized 1536-well format gamma-secretase assay.

Assay Drug Dev Technol 2009 Oct;7(5):461-70

Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1089/adt.2009.0202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096545PMC
October 2009

Quantitative analysis of hepatic hypoxia-inducible factor-1alpha and its abnormal gene expression during the formation of hepatocellular carcinoma.

Hepatobiliary Pancreat Dis Int 2009 Aug;8(4):407-13

Research Center of Clinical Molecular Biology, Affiliated Hospital of Nantong University, Nantong 226001, China.

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August 2009

An exo-cell assay for examining real-time gamma-secretase activity and inhibition.

Mol Neurodegener 2009 Jun 2;4:22. Epub 2009 Jun 2.

Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1186/1750-1326-4-22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224971PMC
June 2009

Gender- and age-dependent gamma-secretase activity in mouse brain and its implication in sporadic Alzheimer disease.

PLoS One 2009 7;4(4):e5088. Epub 2009 Apr 7.

Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0005088PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661375PMC
July 2009

Ligand-dependent Notch signaling is involved in tumor initiation and tumor maintenance in pancreatic cancer.

Clin Cancer Res 2009 Apr 3;15(7):2291-301. Epub 2009 Mar 3.

Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711441PMC
April 2009

gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity.

Cancer Res 2009 Jan;69(2):573-82

Department of Medicine, Division of Solid Tumor Oncology, Laboratory of New Drug Development, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-2088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242515PMC
January 2009

Stereo-controlled synthesis of novel photoreactive gamma-secretase inhibitors.

Bioorg Med Chem Lett 2009 Feb 7;19(3):922-5. Epub 2008 Dec 7.

Organic Synthesis Core Facility, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.bmcl.2008.11.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254698PMC
February 2009

Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes.

J Biol Chem 2009 Jan 25;284(5):2967-77. Epub 2008 Nov 25.

Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1074/jbc.M807269200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631949PMC
January 2009

Soluble oligomers of the intramembrane serine protease YqgP are catalytically active in the absence of detergents.

Biochemistry 2008 Nov 21;47(46):11920-9. Epub 2008 Oct 21.

Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA.

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https://pubs.acs.org/doi/10.1021/bi800385r
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http://dx.doi.org/10.1021/bi800385rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643057PMC
November 2008

[Dynamic expression and quantitative analysis of hepatic nuclear factor-kappa B and its gene during the development of hepatocellular carcinoma].

Zhonghua Gan Zang Bing Za Zhi 2008 Sep;16(9):669-73

Affiliated Hospital of Nantong University, Nantong 226001, China.

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September 2008

A dimeric Smac/diablo peptide directly relieves caspase-3 inhibition by XIAP. Dynamic and cooperative regulation of XIAP by Smac/Diablo.

J Biol Chem 2007 Oct 27;282(42):30718-27. Epub 2007 Aug 27.

Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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http://dx.doi.org/10.1074/jbc.M705258200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202417PMC
October 2007

{gamma}-Secretase Substrate Concentration Modulates the Abeta42/Abeta40 Ratio: IMPLICATIONS FOR ALZHEIMER DISEASE.

J Biol Chem 2007 Aug 7;282(32):23639-44. Epub 2007 Jun 7.

Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021 and Department of Biology, Rensselaer Polytechnic Institute, Troy, New York 12180.

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http://dx.doi.org/10.1074/jbc.M704601200DOI Listing
August 2007

High-throughput identification of inhibitors of human mitochondrial peptide deformylase.

J Biomol Screen 2007 Jun 13;12(4):521-35. Epub 2007 Apr 13.

High Throughput Screening Core Facility, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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http://dx.doi.org/10.1177/1087057107300463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234356PMC
June 2007

Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors.

Cancer Res 2006 Aug;66(15):7445-52

Department of Pathology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-0858DOI Listing
August 2006

A new class of versatile chiral-bridged atropisomeric diphosphine ligands: remarkably efficient ligand syntheses and their applications in highly enantioselective hydrogenation reactions.

J Am Chem Soc 2006 May;128(17):5955-65

Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.

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http://dx.doi.org/10.1021/ja0602694DOI Listing
May 2006

Highly enantioselective addition of in situ prepared arylzinc to aldehydes catalyzed by a series of atropisomeric binaphthyl-derived amino alcohols.

Chemistry 2006 May;12(15):4115-20

Open Laboratory of Chirotechnology of the Institute of Molecular, Technology for Drug Discovery and Synthesis State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Shenzhen), Kowloon, Hong Kong, China.

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http://dx.doi.org/10.1002/chem.200501048DOI Listing
May 2006

Total synthesis of (+/-)-jiadifenin and studies directed to understanding its SAR: probing mechanistic and stereochemical issues in palladium-mediated allylation of enolate-like structures.

J Am Chem Soc 2006 Jan;128(3):1016-22

Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10021, USA.

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http://dx.doi.org/10.1021/ja056980aDOI Listing
January 2006

Total synthesis as a resource in drug discovery: the first in vivo evaluation of panaxytriol and its derivatives.

J Org Chem 2005 Dec;70(25):10375-80

Department of Chemistry, Columbia University, 3000 Broadway, New York, New York, 10027, USA.

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http://dx.doi.org/10.1021/jo0515475DOI Listing
December 2005

A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage.

J Neurochem 2006 Jan 21;96(1):118-25. Epub 2005 Nov 21.

Department of Biological Chemistry, Merck Research Laboratories, West Point, Pennsylvania, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2005.03528.xDOI Listing
January 2006

The synthesis and preliminary biological evaluation of a novel steroid with neurotrophic activity: NGA0187.

J Org Chem 2005 Nov;70(24):9849-56

Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10021, USA.

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http://dx.doi.org/10.1021/jo051556dDOI Listing
November 2005

Total synthesis of (-)-scabronine G, an inducer of neurotrophic factor production.

J Am Chem Soc 2005 Oct;127(39):13514-5

Laboratory for Bioorganic Chemistry and Laboratory of Biochemistry and Pharmacology, Sloan-Kettering Institute for Cancer Research, New York, New York 10021, USA.

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http://pubs.acs.org/doi/abs/10.1021/ja055220x
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http://dx.doi.org/10.1021/ja055220xDOI Listing
October 2005

Synthesis and biological evaluation of functionalized coumarins as acetylcholinesterase inhibitors.

Eur J Med Chem 2005 Dec 21;40(12):1307-15. Epub 2005 Sep 21.

School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China.

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http://dx.doi.org/10.1016/j.ejmech.2005.07.014DOI Listing
December 2005

Rhodium-catalyzed asymmetric aqueous Pauson-Khand-type reaction.

Chemistry 2005 Jun;11(13):3872-80

Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis, Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hung Hom, Hong Kong.

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http://dx.doi.org/10.1002/chem.200401237DOI Listing
June 2005

Synthesis of zwitterionic 4-hydroxycoumarin derivatives through a unique reaction of 4-hydroxycoumarins with p- benzoquinone and pyridine.

Org Lett 2004 Dec;6(26):4853-5

School of Pharmaceutical Science, Sun Yat-Sen University, Guangzhou, 510275 People's Republic of China.

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http://dx.doi.org/10.1021/ol048109pDOI Listing
December 2004

Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct.

Proc Natl Acad Sci U S A 2004 Dec 24;101(49):17050-5. Epub 2004 Nov 24.

Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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http://dx.doi.org/10.1073/pnas.0408007101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC535399PMC
December 2004

Total synthesis of (+/-)-jiadifenin, a non-peptidyl neurotrophic modulator.

J Am Chem Soc 2004 Nov;126(44):14358-9

Laboratory for Bioorganic Chemistry and Laboratory of Biochemistry and Pharmacology, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10021, USA.

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http://dx.doi.org/10.1021/ja045939pDOI Listing
November 2004