Publications by authors named "Yuchun Li"

94 Publications

The complete mitochondrial genome of (Rodentia: Muridae).

Mitochondrial DNA B Resour 2022 29;7(7):1369-1371. Epub 2022 Jul 29.

Marine College, Shandong University, Weihai, China.

(Rodentia: Muridae) had been regarded as a subspecies of , i.e. , and was raised as a distinct species recently by our laboratory. We sequenced the complete mitochondrial genome of first and annotated the genome structure. The total length of the genome was 16,308 base pairs (bp) containing 13 protein-coding genes (PCGs), two ribosomal RNA genes (rRNAs), 22 transfer RNA genes (tRNAs), and a control region. We also constructed the phylogenetic tree by maximum-likelihood method and it demonstrated that was the sister clade of .
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http://dx.doi.org/10.1080/23802359.2022.2100289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9341373PMC
July 2022

Automatic Segmentation of Prostate MRI Based on 3D Pyramid Pooling Unet.

Med Phys 2022 Aug 3. Epub 2022 Aug 3.

Haikou Municipal People's Hospital and Central South University Xiangya Medical College Affiliated Hospital, Haikou, 570288, China.

Purpose: Automatic segmentation of prostate magnetic resonance (MR) images is crucial for the diagnosis, evaluation, and prognosis of prostate diseases (including prostate cancer). In recent years, the mainstream segmentation method for the prostate has been converted to convolutional neural networks. However, owing to the complexity of the tissue structure in MR images and the limitations of existing methods in spatial context modeling, the segmentation performance should be improved further METHODS: : In this study, we proposed a novel 3D pyramid pool Unet (3D PPU-net), which benefits from the pyramid pooling structure embedded in the skip connection and the deep supervision in the up-sampling of the 3D Unet. The parallel skip connection of the conventional 3D Unet network causes low-resolution information to be sent to the feature map repeatedly, resulting in blurred image features. To overcome the shortcomings of the conventional 3D Unet, we merge each decoder layer with the feature map of the same scale as the encoder and the smaller-scale feature map of the pyramid pooling encoder. This skip connection combines the low-level details and high-level semantics at two different levels of feature maps. In addition, pyramid pooling performs multi-faceted feature extraction on each image behind the convolutional layer, and deep supervision learns hierarchical representations from comprehensive aggregated feature maps, which can improve the accuracy of the task.

Results: Experiments on 3D prostate MR images of 78 patients demonstrated that our results were highly correlated with expert manual segmentation. The average relative volume difference (RVD) and Dice similarity coefficient (DSC) of the prostate volume area were 2.32% and 91.03%, respectively.

Conclusion: Quantitative experiments demonstrate that, compared with other methods, the results of our method are highly consistent with the expert manual segmentation. This article is protected by copyright. All rights reserved.
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http://dx.doi.org/10.1002/mp.15895DOI Listing
August 2022

Automatic prostate and peri-prostatic fat segmentation based on pyramid mechanism fusion network for T2-weighted MRI.

Comput Methods Programs Biomed 2022 Aug 20;223:106918. Epub 2022 Jun 20.

Haikou Municipal People's Hospital and Central South University Xiangya Medical College Affiliated Hospital, Haikou 570288, China.

Background And Objective: Automatic and accurate segmentation of prostate and peri-prostatic fat in male pelvic MRI images is a critical step in the diagnosis and prognosis of prostate cancer. The boundary of prostate tissue is not clear, which makes the task of automatic segmentation very challenging. The main issues, especially for the peri-prostatic fat, which is being offered for the first time, are hazy boundaries and a large form variation.

Methods: We propose a pyramid mechanism fusion network (PMF-Net) to learn global features and more comprehensive context information. In the proposed PMF-Net, we devised two pyramid techniques in particular. A pyramid mechanism module made of dilated convolutions of varying rates is inserted before each down sample of the fundamental network architecture encoder. The module is intended to address the issue of information loss during the feature coding process, particularly in the case of segmentation object boundary information. In the transition stage from encoder to decoder, pyramid fusion module is designed to extract global features. The features of the decoder not only integrate the features of the previous stage after up sampling and the output features of pyramid mechanism, but also include the features of skipping connection transmission under the same scale of the encoder.

Results: The segmentation results of prostate and peri-prostatic fat on numerous diverse male pelvic MRI datasets show that our proposed PMF-Net has higher performance than existing methods. The average surface distance (ASD) and Dice similarity coefficient (DSC) of prostate segmentation results reached 10.06 and 90.21%, respectively. The ASD and DSC of the peri-prostatic fat segmentation results reached 50.96 and 82.41%.

Conclusions: The results of our segmentation are substantially connected and consistent with those of expert manual segmentation. Furthermore, peri-prostatic fat segmentation is a new issue, and good automatic segmentation has substantial therapeutic implications.
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http://dx.doi.org/10.1016/j.cmpb.2022.106918DOI Listing
August 2022

Surveillance and response systems driving malaria elimination in the mountain areas of Hainan Province.

Adv Parasitol 2022 18;116:69-113. Epub 2022 Mar 18.

Hainan Provincial Center for Disease Control & Prevention, Haikou, Hainan, PR China. Electronic address:

Hainan Province is in a tropical area of China and previously experienced serious P. falciparum and P. vivax malaria epidemics. After nearly 70 consecutive years of malaria prevention and control, malaria in Hainan has gradually been eliminated. To achieve the elimination of malaria, Hainan enacted six stages: investigative research and pilot prevention and control, large-scale antimalaria measures, adjustment of strategies for prevention and control, joint prevention and control measures, global funding of routine malaria control, and malaria elimination. Different strategies for malaria control were adopted at different stages. Malaria was most prevalent in the mountainous areas of central and southern Hainan, which contain a high-risk population (the forest goers) and two highly effective malaria vectors (An. dirus and An. minimus). Forest goers have been a high-risk population for malaria in Hainan since their identification in the 1990s. This paper summarizes malaria monitoring in forest goers and the response of forest goers to malaria control and elimination, distilling specific malaria control and elimination measures via case studies in Hainan Province. Two case studies in the malaria control stage demonstrated different measures for outbreaks and sporadic cases in forest goers. In view of the malaria outbreak in Sanya during the elimination stage, three-layered strategies (TLSs) were implemented to control outbreaks and improve control measures. Moreover, this paper also illustrates specific management measures to prevent malaria retransmission from sporadic imported malaria cases during the elimination phase. Hainan finally eliminated malaria in 2020. However, the risk of malaria retransmission is still high due to the prevalence of effective malaria vectors in Hainan, and forest goers are still a high-risk population for malaria retransmission.
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http://dx.doi.org/10.1016/bs.apar.2022.01.001DOI Listing
June 2022

Whole-genome sequencing as an alternative to analyze copy number abnormalities in acute myeloid leukemia and myelodysplastic syndrome.

Leuk Lymphoma 2022 Jun 11:1-10. Epub 2022 Jun 11.

Central Laboratory, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, China.

Copy number aberrations (CNA) are the core determinants for diagnosis, risk stratification and prognosis in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). In this study, a shallow whole-genome sequencing-based assay, LeukoPrint, was utilized to depict genomic CNA profiles from the bone marrow of 137 newly diagnosed AML/MDS patients. It demonstrated 98.1% concordance of CNA profiles with cytogenetics and/or fluorescence in situ hybridization (FISH). It is advantageous in detecting CNAs of short segments (1 Mb) and from samples with low leukemic cell content, more accurate for describing complex karyotypes and less confounded by subjective bias. LeukoPrint improved the overall diagnostic yield by redefining the risk categories for 16 patients by presenting new information. In summary, LeukoPrint provided an automated, convenient, and cost-effective approach to describe genomic CNA profiles. It brought greater diagnostic yield and risk stratification information by incorporating into the routine cytogenetics based on the CNA-related criteria of standard ELN/IPSS-R guidelines.
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http://dx.doi.org/10.1080/10428194.2022.2080821DOI Listing
June 2022

Malaria elimination on Hainan Island despite climate change.

Commun Med (Lond) 2022 9;2:12. Epub 2022 Feb 9.

Department of Zoology, University of Oxford, Oxford, UK.

Background: Rigorous assessment of the effect of malaria control strategies on local malaria dynamics is a complex but vital step in informing future strategies to eliminate malaria. However, the interactions between climate forcing, mass drug administration, mosquito control and their effects on the incidence of malaria remain unclear.

Methods: Here, we analyze the effects of interventions on the transmission dynamics of malaria ( and ) on Hainan Island, China, controlling for environmental factors. Mathematical models were fitted to epidemiological data, including confirmed cases and population-wide blood examinations, collected between 1995 and 2010, a period when malaria control interventions were rolled out with positive outcomes.

Results: Prior to the massive scale-up of interventions, malaria incidence shows both interannual variability and seasonality, as well as a strong correlation with climatic patterns linked to the El Nino Southern Oscillation. Based on our mechanistic model, we find that the reduction in malaria is likely due to the large scale rollout of insecticide-treated bed nets, which reduce the infections of and malaria by 93.4% and 35.5%, respectively. Mass drug administration has a greater contribution in the control of (54.9%) than (5.3%). In a comparison of interventions, indoor residual spraying makes a relatively minor contribution to malaria control (1.3%-9.6%).

Conclusions: Although malaria transmission on Hainan Island has been exacerbated by El Nino Southern Oscillation, control methods have eliminated both and malaria from this part of China.
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http://dx.doi.org/10.1038/s43856-022-00073-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053252PMC
February 2022

The effect of particle size and mass ratio on the mechanical response of Al/PTFE/SiC composite with a 2 factorial design.

RSC Adv 2022 Jan 20;12(5):2810-2819. Epub 2022 Jan 20.

College of Field Engineering, Army Engineering University of PLA Nanjing 210007 China

In order to study the effects of different SiC mass ratios, SiC particle sizes and Al particle sizes on the mechanical response of Al/PTFE/SiC, an experiment was conducted through the full 2 factorial design. The specimens were prepared by means of molding-vacuum sintering, while the mechanical response of the materials was measured through quasi-static compression. The regression models between failure stress, failure strain and various factors were established respectively and then verified through the analysis of variance (ANOVA) and residual analysis. Besides, the relationship between factors and response as well as that between factors were analyzed using response surface plots. According to the analytical results, the ultimate compressive strength of the material can be improved either by reducing the particle size of SiC and Al or increasing the mass ratio of SiC, while the ductility of the material can be enhanced by maintaining the interaction between SiC mass ratio and SiC particle size at high levels. The interaction effects are significant and can not be ignored, especially the interaction between SiC mass ratio and SiC particle size has an important impact on the mechanical responses, which shows that SiC has a greater influence than Al particles in the material system.
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http://dx.doi.org/10.1039/d1ra07985aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979092PMC
January 2022

The relationship between rising temperatures and malaria incidence in Hainan, China, from 1984 to 2010: a longitudinal cohort study.

Lancet Planet Health 2022 04;6(4):e350-e358

State Key Laboratory of Remote Sensing Science, Center for Global Change and Public Health, College of Global Change and Earth System Science, Beijing Normal University, Beijing, China. Electronic address:

Background: The influence of rising global temperatures on malaria dynamics and distribution remains controversial, especially in central highland regions. We aimed to address this subject by studying the spatiotemporal heterogeneity of malaria and the effect of climate change on malaria transmission over 27 years in Hainan, an island province in China.

Methods: For this longitudinal cohort study, we used a decades-long dataset of malaria incidence reports from Hainan, China, to investigate the pattern of malaria transmission in Hainan relative to temperature and the incidence at increasing altitudes. Climatic data were obtained from the local meteorological stations in Hainan during 1984-2010 and the WorldClim dataset. A temperature-dependent R model and negative binomial generalised linear model were used to decipher the relationship between climate factors and malaria incidence in the tropical region.

Findings: Over the past few decades, the annual peak incidence has appeared earlier in the central highland regions but later in low-altitude regions in Hainan, China. Results from the temperature-dependent model showed that these long-term changes of incidence peak timing are linked to rising temperatures (of about 1·5°C). Further, a 1°C increase corresponds to a change in cases of malaria from -5·6% (95% CI -4·5 to -6·6) to -9·2% (95% CI -7·6 to -10·9) from the northern plain regions to the central highland regions during the rainy season. In the dry season, the change in cases would be 4·6% (95% CI 3·7 to 5·5) to 11·9% (95% CI 9·8 to 14·2) from low-altitude areas to high-altitude areas.

Interpretation: Our study empirically supports the idea that increasing temperatures can generate opposing effects on malaria dynamics for lowland and highland regions. This should be further investigated and incorporated into future modelling, disease burden calculations, and malaria control, with attention for central highland regions under climate change.

Funding: Scientific and Technological Innovation 2030: Major Project of New Generation Artificial Intelligence, National Natural Science Foundation of China, Beijing Natural Science Foundation, National Key Research and Development Program of China, Young Elite Scientist Sponsorship Program by CAST, Research on Key Technologies of Plague Prevention and Control in Inner Mongolia Autonomous Region, and Beijing Advanced Innovation Program for Land Surface Science.
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http://dx.doi.org/10.1016/S2542-5196(22)00039-0DOI Listing
April 2022

Discovery of Lijianmin-Chengkun Complexes and Their Oncological Application in Osseous and Intraarticular Lesions Around the Knee.

Front Surg 2021 3;8:691362. Epub 2021 Dec 3.

Department of Orthopedics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

This research aims to refresh the limited understanding about the canal and vascular structures within the epiphysis and metaphysis of the tibia and femur and their oncological significance. This study was started with characterization of a novel structure using radiographs and anatomic dissections, followed by a descriptive clinical study with 55 participants to investigate the effects of tumors on this novel discovery and a retrospective cohort study with 82 participants to investigate whether the structure would be a risk factor for tumor recurrence after the curettage of giant cell tumor of bone. A new anatomical knee structure, the Lijianmin-Chengkun (LC) complex, was discovered in healthy adults, and its clinical implications were examined in this study. This new-found anatomical structure is composed of an epiphyseal and metaphyseal canal which surrounds a blood vessel, foramen, and foramen-covered synovium. All LC complexes showed similar radiographical, anatomical, and histological characteristics and were located within specific tibial and femoral intercondylar regions. These LC complexes seem to facilitate tumor residue and extension and may be a risk factor for tumor recurrence after curettage of femoral and tibial giant cell tumors ( = 0.031). The LC complexes are related to local tumor recurrence and bidirectional tumor dissemination between intraosseous and intraarticular regions. These findings have opened up a new perspective and may provide new targets for intervention in malignant and aggressive tumors around the knee joint.
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http://dx.doi.org/10.3389/fsurg.2021.691362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677826PMC
December 2021

Enhancing the flame retardancy and UV resistance of polyamide 6 by introducing ternary supramolecular aggregates.

Chemosphere 2022 Jan 1;287(Pt 2):132100. Epub 2021 Sep 1.

State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing, 100029, China; Key Laboratory of Carbon Fiber and Functional Polymers, Ministry of Education, Beijing University of Chemical Technology, Beijing, 100029, China. Electronic address:

An integrated multi-functional additive was fabricated by successively grafting melamine (MEL) and phytic acid (PhA) on multiwalled carbon-nanotubes (MWNCTs), and was then applied in PA6 to improve the flame retardancy and light aging resistance of the composite. The limit oxygen index of PA6 composite containing 7 wt% PhA-MEL-MWCNTs was increased to 26.4 from 21.0. The smoke and CO release were significantly reduced by 48% and 88% respectively, and the severe melt dripping of PA6 in burning was eliminated. It is proved that PhA-MEL-MWCNTs can absorb ultraviolet (UV) radiation, and hence significantly reduces the mechanical property loss of the PA6 composite after UV aging. The tensile strength of the aged PA6/7 wt%PhA-MEL-MWCNTs composite sample only decreased by 18.1%, which was significantly lower than the loss rate of the control aged PA6 sample (62.5%). This protocol provides a new opportunity for fabricating long-life flame retardant polyamide composites.
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http://dx.doi.org/10.1016/j.chemosphere.2021.132100DOI Listing
January 2022

Estimating the COVID-19 prevalence and mortality using a novel data-driven hybrid model based on ensemble empirical mode decomposition.

Sci Rep 2021 11 1;11(1):21413. Epub 2021 Nov 1.

Department of Epidemiology and Health Statistics, School of Public Health, Xinxiang Medical University, No. 601 Jinsui Road, Hongqi District, Xinxiang City, 453003, Henan Province, People's Republic of China.

In this study, we proposed a new data-driven hybrid technique by integrating an ensemble empirical mode decomposition (EEMD), an autoregressive integrated moving average (ARIMA), with a nonlinear autoregressive artificial neural network (NARANN), called the EEMD-ARIMA-NARANN model, to perform time series modeling and forecasting based on the COVID-19 prevalence and mortality data from 28 February 2020 to 27 June 2020 in South Africa and Nigeria. By comparing the accuracy level of forecasting measurements with the basic ARIMA and NARANN models, it was shown that this novel data-driven hybrid model did a better job of capturing the dynamic changing trends of the target data than the others used in this work. Our proposed mixture technique can be deemed as a helpful policy-supportive tool to plan and provide medical supplies effectively. The overall confirmed cases and deaths were estimated to reach around 176,570 [95% uncertainty level (UL) 173,607 to 178,476] and 3454 (95% UL 3384 to 3487), respectively, in South Africa, along with 32,136 (95% UL 31,568 to 32,641) and 788 (95% UL 775 to 804) in Nigeria on 12 July 2020 using this data-driven EEMD-ARIMA-NARANN hybrid technique. The contributions of this study include three aspects. First, the proposed hybrid model can better capture the dynamic dependency characteristics compared with the individual models. Second, this new data-driven hybrid model is constructed in a more reasonable way relative to the traditional mixture model. Third, this proposed model may be generalized to estimate the epidemic patterns of COVID-19 in other regions.
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http://dx.doi.org/10.1038/s41598-021-00948-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560776PMC
November 2021

Improving the flame retardancy and accelerating the degradation of poly (lactic acid) in soil by introducing fully bio-based additives.

Int J Biol Macromol 2021 Dec 22;193(Pt A):44-52. Epub 2021 Oct 22.

State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing, China; Beijing Key Laboratory of Advanced Functional Polymer Composites, Beijing University of Chemical Technology, Beijing, China. Electronic address:

In this study, a novel bio-based flame retardant LC-PA is prepared by the Mannich reaction between phytic acid (PA) and L-citrulline (LC). LC-PA is combined with tannic acid (TA) and introduced into PLA to improve fire performance and accelerate biodegradability. Compared with control PLA, the PLA composite containing 10% LC-PA/TA increases the LOI value to 26.9%, reaches a V-0 rating in the UL-94 test, and reduces the peak heat release rate and total heat release by 24.5% and 21.1%, respectively. More importantly, the introduction of LC-PA/TA accelerates the degradation rate of PLA in soil, which is of significance for biodegradable materials. The addition of LC-PA/TA can attract water and provide a suitable energy source for microbial proliferation, accelerating the hydrolysis and microbial degradation of PLA. This work provides a practical approach for high flame retardancy and rapid biodegradability in the soil to the bio-based polymer.
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http://dx.doi.org/10.1016/j.ijbiomac.2021.10.119DOI Listing
December 2021

Genome-wide mRNA profiling identifies the NRF2-regulated lymphocyte oxidative stress status in patients with silicosis.

J Occup Med Toxicol 2021 Sep 13;16(1):40. Epub 2021 Sep 13.

School of Public Health, North China University of Science and Technology, Tangshan, Hebei Province, 063009, People's Republic of China.

Background: The immunomodulatory abnormalities of silicosis are related to the lymphocyte oxidative stress state. The potential effect of antioxidant therapy on silicosis may depend on the variation in nuclear factor erythroid 2-related factor 2 (NRF2)-regulated antioxidant genes in peripheral blood mononuclear cells (PBMCs). As NRF2 is a redox-sensitive transcription factor, its possible roles and underlying mechanism in the treatment of silicosis need to be clarified.

Methods: Ninety-two male patients with silicosis and 87 male healthy volunteers were randomly selected. PBMCs were isolated from fresh blood from patients with silicosis and healthy controls. The lymphocyte oxidative stress state was investigated by evaluating NRF2 expression and NRF2-dependent antioxidative genes in PBMCs from patients with silicosis. Key differentially expressed genes (DEGs) and signaling pathways were identified utilizing RNA sequencing (RNA-Seq) and bioinformatics technology. Gene set enrichment analysis was used to identify the differences in NRF2 signaling networks between patients with silicosis and healthy controls.

Results: The number of monocytes was significantly higher in patients with silicosis than that of healthy controls. Furthermore, RNA-Seq findings were confirmed using quantitative polymerase chain reaction and revealed that NRF2-regulated DEGs were associated with glutathione metabolism, transforming growth factor-β, and the extracellular matrix receptor interaction signaling pathway in PBMCs from patients with silicosis. The top 10 hub genes were identified by PPI analysis: SMAD2, MAPK3, THBS1, SMAD3, ITGB3, integrin alpha-V (ITGAV), von Willebrand factor (VWF), BMP4, CD44, and SMAD7.

Conclusions: These findings suggest that NRF2 signaling regulates the lymphocyte oxidative stress state and may contribute to fibrogenic responses in human PBMCs. Therefore, NRF2 might serve as a novel preventive and therapeutic candidate for silicosis.
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http://dx.doi.org/10.1186/s12995-021-00332-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436508PMC
September 2021

Comment on "efficacy of platelet-rich plasma injections in patients with adhesive capsulitis of the shoulder".

Int Orthop 2021 11;45(11):3005-3006

Department of Bone Tumor, Qilu Hospital of Shandong University, Qingdao, 266035, Shandong, China.

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http://dx.doi.org/10.1007/s00264-021-05134-xDOI Listing
November 2021

Alpha-lipoic acid attenuates silica-induced pulmonary fibrosis by improving mitochondrial function via AMPK/PGC1α pathway activation in C57BL/6J mice.

Toxicol Lett 2021 Oct 9;350:121-132. Epub 2021 Jul 9.

School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, PR China. Electronic address:

Silicosis is characterized by pulmonary interstitial fibrosis that arises as a result of chronic exposure to silica. The few available treatments only delay its progression. As α-lipoic acid (ALA) has been shown to have various beneficial effects, including mitoprotective, antioxidant, and anti-inflammatory effects, we hypothesized that it may exhibit therapeutic effects in pulmonary fibrosis. Therefore, in the present study, we used a murine model of silicosis to investigate whether supplementation with exogenous ALA could attenuate silica-induced pulmonary fibrosis by improving mitochondrial function. ALA was administered to the model mice via continuous intragastric administration for 28 days, and then the antioxidant and mitoprotective effects of ALA were evaluated. The results showed that ALA decreased the production of reactive oxygen species, protected mitochondria from silica-induced dysfunction, and inhibited extracellular matrix deposition. ALA also decreased hyperglycemia and hyperlipidemia. Activation of the mitochondrial AMPK/PGC1α pathway might be responsible for these ALA-mediated anti-fibrotic effects. Exogenous ALA blocked oxidative stress by activating NRF2. Taken together, these findings demonstrate that exogenous ALA effectively prevents the progression of silicosis in a murine model, likely by stimulating mitochondrial biogenesis and endogenous antioxidant responses. Therefore, ALA can potentially delay the progression of silica-induced pulmonary fibrosis.
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http://dx.doi.org/10.1016/j.toxlet.2021.07.003DOI Listing
October 2021

Comment on "efficacy of platelet-rich plasma injections in patients with adhesive capsulitis of the shoulder".

Int Orthop 2021 08 8;45(8):2171-2172. Epub 2021 Jul 8.

Department of Bone Tumor, Qilu Hospital of Shandong University, Qingdao, 266035, Shandong, China.

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http://dx.doi.org/10.1007/s00264-021-05065-7DOI Listing
August 2021

Characterization of the complete mitochondrial genome of Dongyangjiang White-toothed Shrew, (Eulipotyphla: Soricidae) and its phylogenetic analysis.

Mitochondrial DNA B Resour 2021 Mar 18;6(3):1004-1006. Epub 2021 Mar 18.

Marine College, Shandong University, Weihai, China.

The complete mitochondrial genome of the Dongyangjiang White-toothed Shrew (), a newly discovered species, is sequenced and characterized. The total length of the genome is 16,883 bp, and has similar base composition and gene arrangement to other vertebrates. It contains 13 protein-coding genes (PCGs), two ribosomal RNA (rRNA), 22 transfer RNA (tRNA), a replication origin (OL) and a control region. The phylogenetic tree shows that was fully resolved in a clade with three other species of and it has a sibling relationship with . This analysis reveals the evolutionary relationship of 16 species.
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http://dx.doi.org/10.1080/23802359.2021.1893617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995850PMC
March 2021

Influence of halogen atom substitution and neutral HCN/anion CN Lewis base on the triel-bonding interactions.

J Mol Model 2021 Feb 23;27(3):93. Epub 2021 Feb 23.

School of Physical Science and Technology, Southwest Jiaotong University, Chengdu, 611756, People's Republic of China.

Triel-bonding interactions composed of Lewis acid TrOHH/TrOHX/TrOHX (Tr = B, Al, Ga; X = F, Cl, Br) molecule and Lewis base neutral HCN or anionic CN molecule are of research significance in bond properties, which has been investigated at MP2/aug-cc-pVTZ theory level. It is also feasible to study the halogen atom substituent effect and influence of different Lewis bases on the formation of triel bond. AIM analyses reveal that Tr (Tr = B, Al, Ga)···N bond critical point (BCP) exists in all studied triel bond. In the formation of triel bonding, compared with Lewis base HCN molecule, Lewis base anionic CN can participate in a stronger triel bond. Specifically, the structural change, deformation energy, and charge transfer of CN complexes are all larger than that of HCN complexes. In addition, halogen atom substitution effect is also discussed. MEP value and binding energy of HCN and CN complexes all increase after replacing one or two hydrogen atoms by halogen atoms (F, Cl, Br) in Lewis acid. Especially, replacing two hydrogen atoms by halogen atoms in Lewis acid has more remarkable enhancement in MEP value and binding energy than that of replacing only one hydrogen atom. After replacement, binding energy can be increased by 21.77 kcal/mol. The neutral and anionic triel-bonded complexes composed by Lewis acid TrOHH/TrOHX/TrOHX (Tr = B, Al, Ga; X = F, Cl, Br) with Lewis base HCN and CN are systematically investigated at MP2/aug-cc-pVTZ level. The neutral (HCN) triel bonding is weaker than the anionic (CN) triel bonding due to the smaller MEP value of the neutral HCN molecule. The replacement of hydrogens (-H) in Lewis acid by electron-withdrawing groups (-F, -Cl, -Br) has a prominent enhancement effect on the MEP value of π-hole and triel-bonding strength.
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http://dx.doi.org/10.1007/s00894-021-04713-4DOI Listing
February 2021

Effect of addition of HTa to Al/PTFE under quasi-static compression on the properties of the developed energetic composite material.

RSC Adv 2021 Feb 23;11(15):8540-8545. Epub 2021 Feb 23.

China Huayin Ordnance Test Center Huayin Shanxi China.

To study the mechanical properties and reaction characteristics of Al/HTa/PTFE reactive materials under quasi-static compression, five types of Al/HTa/PTFE specimens with different HTa contents were prepared for quasi-static compression tests. The fracture of selected specimens was characterized by scanning electron microscopy (SEM). The quasi-static compression reaction residue underwent X-ray diffraction (XRD) phase analysis, and the chemical reaction mechanism was analyzed based on the result. As revealed from the results, the introduction of HTa significantly influenced the strength of the composites. With the increase in HTa content, the compressive strength of Al/HTa/PTFE materials first decreased and then increased. Under a HTa content of 30%, the compressive strength increased by nearly 10.6%. The microstructure shows that the HTa content in the Al/HTa/PTFE materials affects the bonding force between the metal particles and the PTFE matrix, the integrity of the PTFE matrix and the formation of PTFE bridging filaments between the deformed surfaces of the PTFE matrix, resulting in a difference in compressive strength. HTa increased the reaction duration and smoke concentration, and induced a similar white burning flame at the later phase of the reaction, with greater flame luminosity. The high temperature of the crack tip of the specimen induced the reaction of Al and PTFE and released considerable heat causing HTa to release H, synthesized TaC, and increased the energy density, which achieved the purpose of enhancing the mechanical properties and reaction characteristics of the material.
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http://dx.doi.org/10.1039/d0ra09084kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695173PMC
February 2021

Short-term effect of NO on outpatient visits for dermatologic diseases in Xinxiang, China: a time-series study.

Environ Geochem Health 2021 Sep 9;43(9):1-11. Epub 2021 Feb 9.

Henan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, Xinxiang, 453003, Henan Province, China.

Objectives: As the largest organ of the human body, the skin is the major exposure route of NO. However, the evidence for a relationship between NO exposure and dermatologic diseases (DMs) is limited. This time-series study was conducted to assess the short-term effect of nitrogen dioxide (NO) exposure on DMs outpatient visits in Xinxiang, China.

Methods: Daily recordings of NO concentrations, meteorological data, and the outpatient visits data for DMs were collected in Xinxiang from January 1st, 2015, to December 31st, 2018. The analysis method used was based on the generalized additive model (GAM) with quasi-Poisson regression to investigate the relationship between NO exposure and DMs outpatient visits. Several covariates, such as long-term trends, seasonality, and weather conditions were controlled.

Results: A total of 164,270 DMs outpatients were recorded. A 10 μg/m increase in NO concentrations during the period was associated with a 1.86% increase in DMs outpatient visits (95% confidence intervals [Cl]: 1.06-2.66%). The effect was stronger (around 6 times) in the cool seasons than in warmer seasons and younger patients (< 15 years of age) appeared to be more vulnerable.

Conclusions: The findings of this study indicate that short-term exposure to NO increases the risk of DMs in Xinxiang, China, especially in the cool seasons. Policymakers should implement more stringent air quality standards to improve air quality.
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http://dx.doi.org/10.1007/s10653-021-00831-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871127PMC
September 2021

The Genetic Structure of Chinese Hui Ethnic Group Revealed by Complete Mitochondrial Genome Analyses Using Massively Parallel Sequencing.

Genes (Basel) 2020 11 14;11(11). Epub 2020 Nov 14.

Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China.

Mitochondrial DNA (mtDNA), coupled with maternal inheritance and relatively high mutation rates, provides a pivotal way for us to investigate the formation histories of populations. The Hui minority with Islamic faith is one of the most widely distributed ethnic groups in China. However, the exploration of Hui's genetic architecture from the complete mitochondrial genome perspective has not been detected yet. Therefore, in this study, we employed the complete mitochondrial genomes of 98 healthy and unrelated individuals from Northwest China, as well as 99 previously published populations containing 7274 individuals from all over the world as reference data, to comprehensively dissect the matrilineal landscape of Hui group. Our results demonstrated that Hui group exhibited closer genetic relationships with Chinese Han populations from different regions, which was largely attributable to the widespread of haplogroups D4, D5, M7, B4, and F1 in these populations. The demographic expansion of Hui group might occur during the Late Pleistocene. Finally, we also found that Hui group might have gene exchanges with Uygur, Tibetan, and Tajik groups in different degrees and retained minor genetic imprint of European-specific lineages, therefore, hinting the existence of multi-ethnic integration events in shaping the genetic landscape of Chinese Hui group.
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http://dx.doi.org/10.3390/genes11111352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698084PMC
November 2020

Estimating the Prevalence and Mortality of Coronavirus Disease 2019 (COVID-19) in the USA, the UK, Russia, and India.

Infect Drug Resist 2020 29;13:3335-3350. Epub 2020 Sep 29.

Department of Epidemiology and Health Statistics, School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, People's Republic of China.

Objective: The aim of this study is to apply the advanced error-trend-seasonal (ETS) framework to forecast the prevalence and mortality series of COVID-19 in the USA, the UK, Russia, and India, and the predictive performance of the ETS framework was compared with the most frequently used autoregressive integrated moving average (ARIMA) model.

Materials And Methods: The prevalence and mortality data of COVID-19 in the USA, the UK, Russia, and India between 20 February 2020 and 15 May 2020 were extracted from the WHO website. Then, the data subsamples between 20 February 2020 and 3 May 2020 were treated as the training horizon, and the others were used as the testing horizon to construct the ARIMA models and the ETS models.

Results: Based on the model evaluation criteria, the ARIMA (0,2,1) and ETS (M,MD,N), sparse coefficient ARIMA (0,2,(1,6)) and ETS (A,AD,M), ARIMA (1,1,1) and ETS (A,MD,A), together with ARIMA (2,2,1) and ETS (A,M,A) specifications were identified as the preferred ARIMA and ETS models for the prevalence data in the USA, the UK, Russia, and India, respectively; the ARIMA (0,2,1) and ETS (M,A,M), ARIMA (0,2,1) and ETS (M,A,N), ARIMA (0,2,1) and ETS (A,A,N), coupled with ARIMA (0,2,2) and ETS (M,M,N) specifications were selected as the optimal ARIMA and ETS models for the mortality data in these four countries, respectively. Among these best-fitting models, the ETS models produced smaller forecasting error rates than the ARIMA models in all the datasets.

Conclusion: The ETS framework can be used to nowcast and forecast the long-term temporal trends of the COVID-19 prevalence and mortality in the USA, the UK, Russia, and India, and which provides a notable performance improvement over the most frequently used ARIMA model. Our findings can aid governments as a reference to prepare for and respond to the COVID-19 pandemic both in restricting the transmission of the disease and in lowering the disease-related deaths in the upcoming days.
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http://dx.doi.org/10.2147/IDR.S265292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532899PMC
September 2020

The long-term effects of meteorological parameters on pertussis infections in Chongqing, China, 2004-2018.

Sci Rep 2020 10 14;10(1):17235. Epub 2020 Oct 14.

Department of Epidemiology and Health Statistics, School of Public Health, Xinxiang Medical University, Henan Province, Xinxiang, 453000, People's Republic of China.

Evidence on the long-term influence of climatic variables on pertussis is limited. This study aims to explore the long-term quantitative relationship between weather variability and pertussis. Data on the monthly number of pertussis cases and weather parameters in Chongqing in the period of 2004-2018 were collected. Then, we used a negative binomial multivariable regression model and cointegration testing to examine the association of variations in monthly meteorological parameters and pertussis. Descriptive statistics exhibited that the pertussis incidence rose from 0.251 per 100,000 people in 2004 to 3.661 per 100,000 persons in 2018, and pertussis was a seasonal illness, peaked in spring and summer. The results from the regression model that allowed for the long-term trends, seasonality, autoregression, and delayed effects after correcting for overdispersion showed that a 1 hPa increment in the delayed one-month air pressure contributed to a 3.559% (95% CI 0.746-6.293%) reduction in the monthly number of pertussis cases; a 10 mm increment in the monthly aggregate precipitation, a 1 °C increment in the monthly average temperature, and a 1 m/s increment in the monthly average wind velocity resulted in 3.641% (95% CI 0.960-6.330%), 19.496% (95% CI 2.368-39.490%), and 3.812 (95% CI 1.243-11.690)-fold increases in the monthly number of pertussis cases, respectively. The roles of the mentioned weather parameters in the transmission of pertussis were also evidenced by a sensitivity analysis. The cointegration testing suggested a significant value among variables. Climatic factors, particularly monthly temperature, precipitation, air pressure, and wind velocity, play a role in the transmission of pertussis. This finding will be of great help in understanding the epidemic trends of pertussis in the future, and weather variability should be taken into account in the prevention and control of pertussis.
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http://dx.doi.org/10.1038/s41598-020-74363-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560825PMC
October 2020

Use of meteorological parameters for forecasting scarlet fever morbidity in Tianjin, Northern China.

Environ Sci Pollut Res Int 2021 Feb 7;28(6):7281-7294. Epub 2020 Oct 7.

Department of Epidemiology and Health Statistics, School of Public Health, Xinxiang Medical University, No. 601 Jinsui road, Hongqi District, Xinxiang City, 453003, Henan Province, People's Republic of China.

The scarlet fever incidence has increased drastically in recent years in China. However, the long-term relationship between climate variation and scarlet fever remains contradictory, and an early detection system is lacking. In this study, we aim to explore the potential long-term effects of variations in monthly climatic parameters on scarlet fever and to develop an early scarlet-fever detection tool. Data comprising monthly scarlet fever cases and monthly average climatic variables from 2004 to 2017 were retrieved from the Notifiable Infectious Disease Surveillance System and National Meteorological Science Center, respectively. We used a negative binomial multivariable regression to assess the long-term impacts of weather parameters on scarlet fever and then built a novel forecasting technique by integrating an autoregressive distributed lag (ARDL) method with a nonlinear autoregressive neural network (NARNN) based on the significant meteorological drivers. Scarlet fever was a seasonal disease that predominantly peaked in spring and winter. The regression results indicated that a 1 °C increment in the monthly average temperature and a 1-h increment in the monthly aggregate sunshine hours were associated with 17.578% (95% CI 7.674 to 28.393%) and 0.529% (95% CI 0.035 to 1.025%) increases in scarlet fever cases, respectively; a 1-hPa increase in the average atmospheric pressure at a 1-month lag was associated with 12.996% (95% CI 9.972 to 15.919%) decrements in scarlet fever cases. Based on the model evaluation criteria, the best-performing basic and combined approaches were ARDL(1,0,0,1) and ARDL(1,0,0,1)-NARNN(5, 22), respectively, and this hybrid approach comprised smaller performance measures in both the training and testing stages than those of the basic model. Climate variability has a significant long-term influence on scarlet fever. The ARDL-NARNN technique with the incorporation of meteorological drivers can be used to forecast the future epidemic trends of scarlet fever. These findings may be of great help for the prevention and control of scarlet fever.
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http://dx.doi.org/10.1007/s11356-020-11072-9DOI Listing
February 2021

(Rodentia, Muridae) is a distinct species based on molecular, karyotyping, and morphological evidence.

Zookeys 2020 14;959:137-159. Epub 2020 Aug 14.

Marine College, Shandong University (Weihai), Weihai, Shandong 264209, China Shandong University Weihai China.

Thomas, 1908, which has been regarded as a subspecies of , was found to be a distinct species from based on molecular, karyotyping, and morphological characteristics in this study. was found to belong to a distinct phylogenetic clade in phylogenetic tree constructed using the mitochondrial gene , it clustered with (Bonhote, 1903) from Vietnam and (Milne-Edwards, 1871) from Yunnan, but showed a distant relationship with from adjacent areas. The genetic distance between and was more than 5.8%, reaching the level of interspecific differentiation. The species delimitation indicates that is a monophyletic group. The karyotype of (FN = 55, 8m+4st+32t+X(sm)Y(t)) differed from that of (FN = 59, 6m+4sm+2st+32t+X(sm)Y(t)). In terms of morphological features, the length of incisive foramen (LIF) and length of auditory bulla (LAB) of is significantly larger than that of and ( < 0.05) and the proportion of white tail tip to total tail length is significantly longer at (≥ 1/3) than that at (≤ 1/3). Therefore, integrated analysis confirmed that is a distinct species of genus rather than a subspecies of or , namely , which is only distributed in Shandong.
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http://dx.doi.org/10.3897/zookeys.959.53426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442754PMC
August 2020

Fabrication of NiCoS/carbon-filled nickel foam complex as an advanced binder-free electrode for supercapacitors.

Dalton Trans 2020 Sep;49(35):12345-12353

Department of Materials Science and Engineering, School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.

A novel strategy, composed of epoxy-resin filling, carbonization, and hydrothermal growing of NiCo2S4 nanorods, was developed to enlarge the surface area of nickel foam (NF) for loading electrochemically active materials and to successfully fabricate NiCo2S4/carbon-filled NF binder-free electrodes. Due to the certain electrical conductivity of the filled epoxy-resin-derived carbon and the enlarged loading surface area, the targeted electrode possesses outstanding electrochemical energy storage performance, with a maximum specific capacitance of 9.28 F cm-2 at a current density of 4 mA cm-2, more than 6 times the 1.46 F cm-2 of the NF-based electrode formed via directly growing NiCo2S4 on NF, and with a specific capacitance retention of about 60% after 2000 charge/discharge cycles. Our strategy provides a promising avenue for constructing a high-performance NF-based binder-free electrode and our resultant electrode presents great application potential in electrochemical energy storage.
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http://dx.doi.org/10.1039/d0dt02160aDOI Listing
September 2020

A biomass-derived super-flexible hierarchically porous carbon film electrode prepared environment-friendly ice-microcrystal pore-forming for supercapacitors.

Chem Commun (Camb) 2020 Sep;56(73):10730-10733

Department of Materials Science and Engineering, School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.

An efficient environmentally friendly purely-physical ice-microcrystal pore-forming strategy, consisting of three steps including the water-swelling biomass process utilizing N-methylmorpholine-N-oxide, freeze-drying and one-step carbonization, was developed to prepare a biomass-derived super-flexible high-performance carbon film electrode capable of being repeatedly folded.
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http://dx.doi.org/10.1039/d0cc04436aDOI Listing
September 2020

Time series analysis of temporal trends in hemorrhagic fever with renal syndrome morbidity rate in China from 2005 to 2019.

Sci Rep 2020 06 15;10(1):9609. Epub 2020 Jun 15.

Department of Epidemiology and Health Statistics, School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, P.R. China.

Hemorrhagic fever with renal syndrome (HFRS) is seriously endemic in China with 70%~90% of the notified cases worldwide and showing an epidemic tendency of upturn in recent years. Early detection for its future epidemic trends plays a pivotal role in combating this threat. In this scenario, our study investigates the suitability for application in analyzing and forecasting the epidemic tendencies based on the monthly HFRS morbidity data from 2005 through 2019 using the nonlinear model-based self-exciting threshold autoregressive (SETAR) and logistic smooth transition autoregressive (LSTAR) methods. The experimental results manifested that the SETAR and LSTAR approaches presented smaller values among the performance measures in both two forecasting subsamples, when compared with the most extensively used seasonal autoregressive integrated moving average (SARIMA) method, and the former slightly outperformed the latter. Descriptive statistics showed an epidemic tendency of downturn with average annual percent change (AAPC) of -5.640% in overall HFRS, however, an upward trend with an AAPC = 1.213% was observed since 2016 and according to the forecasts using the SETAR, it would seemingly experience an outbreak of HFRS in China in December 2019. Remarkably, there were dual-peak patterns in HFRS incidence with a strong one occurring in November until January of the following year, additionally, a weak one in May and June annually. Therefore, the SETAR and LSTAR approaches may be a potential useful tool in analyzing the temporal behaviors of HFRS in China.
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http://dx.doi.org/10.1038/s41598-020-66758-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295973PMC
June 2020

An invited commentary on: "Lingering risk: A meta-analysis of outcomes following primary total knee arthroplasty for patients with post-traumatic arthritis" (int J surg. 2020;77:163-172).

Int J Surg 2020 06 23;78:121. Epub 2020 Apr 23.

Department of Orthopedic, Qilu Hospital of Shandong University (Qingdao), Shandong, 266035, China. Electronic address:

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http://dx.doi.org/10.1016/j.ijsu.2020.04.035DOI Listing
June 2020
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