Publications by authors named "Yucheng Zhou"

49 Publications

[Predictive value of heparin binding protein for sepsis].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Jun;33(6):654-658

Hunan Provincial Institute of Emergency Medicine, Department of Emergency Medicine, Hunan Provincial People's Hospital, the First Affiliated Hospital of Hunan Normal University, Changsha 410005, Hunan, China. Corresponding author: Han Xiaotong, Email:

Objective: To investigate the predictive value of heparin binding protein (HBP) for sepsis.

Methods: From June 2019 to December 2020, 188 patients admitted to the department of emergency of Hunan Provincial People's Hospital were enrolled. The patients were divided into non-sepsis group (87 patients) and sepsis group (101 patients) according to Sepsis-3 criteria. Gender, age, white blood cell count (WBC), C-reactive protein (CRP), procalcitonin (PCT), HBP, sequential organ failure assessment (SOFA) score, quick SOFA (qSOFA) score, modified early warning score (MEWS) and patients' recent medication history were recorded, the differences in the above indicators between the two groups were compared. The risk factors of sepsis were analyzed by Logistic regression. Spearman correlation analysis was used to analyze the correlation between HBP, PCT, CRP and SOFA score to evaluate the predictive value of HBP, PCT and CRP for the severity of septic organ failure. Receiver operating characteristic curve (ROC curve) were drawn to evaluate the diagnostic value of HBP, PCT and CRP for sepsis.

Results: Compared with the non-sepsis group, the sepsis group had significantly higher levels of HBP, PCT, CRP, WBC, SOFA score, qSOFA score, and MEWS [HBP (μg/L): 55.46 (24.57, 78.49) vs. 5.90 (5.90, 9.01), PCT (μg/L): 6.83 (1.75, 30.64) vs. 0.23 (0.12, 0.75), CRP (mg/L): 67.35 (26.23, 123.23) vs. 4.45 (2.62, 47.22), WBC (×10/L): 11.84 (7.18, 16.06) vs. 6.58 (5.47, 8.99), SOFA score: 6 (4, 8) vs. 0 (0, 0), qSOFA score: 2 (1, 3) vs. 0 (0, 1), MEWS: 4 (3, 6) vs. 1 (0, 2)], the length of hospital stay was significantly prolonged [days: 10 (4, 17) vs. 0 (0, 7)], and the mortality was significantly increased [29.7% (30/101) vs. 4.6% (4/87)], with statistical significance (all P < 0.05). Correlation analysis showed that HBP, PCT and CRP were significantly positively correlated with SOFA score (r values were 0.60, 0.33, and 0.38, respectively, all P < 0.01), among which HBP had the strongest correlation, CRP was the second, and PCT was the weakest. Logistic regression analysis showed that HBP, PCT and CRP levels were independent risk factors for sepsis [odds ratio (OR) were 1.015, 1.094, 1.067, 95% confidence intervals (95%CI) were 1.007-1.022, 1.041-1.150, 1.043-1.093, all P < 0.01]. ROC curve analysis showed that HBP, PCT and CRP all had some diagnostic value for sepsis [the area under ROC curve (AUC) were 0.92, 0.87, 0.80, 95%CI were 0.88-0.97, 0.82-0.92, 0.74-0.87, respectively, all P < 0.01]. Among them, the diagnostic efficacy of HBP was higher when the cut-off value was ≥ 15.11 μg/L, its sensitivity and specificity were 86.14% and 89.66%, respectively, which were higher than the sensitivity (81.19%) and specificity (80.46%) when the PCT cut-off value was ≥ 1.17 μg/L. However, CRP had the best sensitivity of 94.06% for the diagnosis of sepsis but lacked of specificity (63.22%).

Conclusions: HBP can be used as a biological indicator for predicting sepsis and can assess the severity of organ failure in septic patients.
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http://dx.doi.org/10.3760/cma.j.cn121430-20210424-00605DOI Listing
June 2021

Overcoming Tumor Hypoxia through Multiple Pathways Using an All-in-One Polymeric Therapeutic Agent to Enhance Synergistic Cancer Photo/Chemotherapy Effects.

Bioconjug Chem 2021 Jul 8. Epub 2021 Jul 8.

State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials & Institute of Flexible Electronics (Future Technology), Nanjing University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing, 210023, China.

Hypoxia is a significant characteristic of tumors, which causes aggressive tumor growth and strong therapy resistance. Inspired by the improved therapeutic efficacy of synergistic treatment, herein, an all-in-one polymeric therapeutic agent was developed, which could overcome tumor hypoxia through multiple pathways. Multiple therapeutic agents were incorporated into the polymer, including the singlet oxygen (O) carrier unit to store cytotoxic reactive oxygen species, the photosensitized and photothermal unit to trigger the capture and release of O, and the hypoxia-responsive prodrug unit to maintain a long-term tumor inhibition. In addition, the hydrophilic polyethylene glycol unit was also introduced to improve water-solubility and biocompatibility. Importantly, this study achieved the capture and controllable release of O just by regulating the power of an 808 nm laser for the first time, which is more convenient and flexible than previous works. As expected, the as-prepared copolymer displayed reduced oxygen dependence, accompanied with promising synergistic anti-tumor and anti-recurrence efficacies under hypoxic and environments. Consequently, this synergistic anti-hypoxia strategy may open up new avenues in the design of all-in-one therapeutic platforms for promoting the development of accurate, efficient, and long-acting treatment in clinical studies.
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http://dx.doi.org/10.1021/acs.bioconjchem.1c00307DOI Listing
July 2021

Event-Triggered Adaptive NN Tracking Control for MIMO Nonlinear Discrete-Time Systems.

IEEE Trans Neural Netw Learn Syst 2021 Jun 15;PP. Epub 2021 Jun 15.

This article concentrates on the design of a novel event-based adaptive neural network (NN) control algorithm for a class of multiple-input-multiple-output (MIMO) nonlinear discrete-time systems. A controller is designed through a novel recursive design procedure, under which the dependence on virtual controls is avoided and only system states are needed. The numbers of the event-triggered conditions and parameters updated online in each subsystem reduce to only one, which largely reduces the computation burden and simplifies the algorithm realization. In this case, radial basis function NNs (RBFNNs) are employed to approximate the control input. The semiglobal uniformly ultimate boundedness (SGUUB) of all the signals in the closed-loop system is guaranteed by the Lyapunov difference approach. The effectiveness of the proposed algorithm is validated by a simulation example.
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http://dx.doi.org/10.1109/TNNLS.2021.3084965DOI Listing
June 2021

Clinicopathological Prognostic Factors and Chemotherapeutic Outcome for Two Histopathological Types of Ampulla of Vater Adenocarcinoma.

Front Oncol 2021 18;11:616108. Epub 2021 Feb 18.

Department of Gastrointestinal-Pancreatic Surgery, Zhejiang Provincial People's Hospital, Hangzhou, China.

Background: Adenocarcinoma of the ampulla of Vater (AAV) is standardly treated using a complex operation, a pancreatoduodenectomy (PD), to remove the tumor. However, dicision-making in AAV clinical treatment remains difficult due to the broad range of AAV types, outcomes, and responses to special chemotherapeutics. Thus, this study aimed to explore clinicopathological prognostic factors associated with overall survival, as well as post-chemotherapeutic effects related to curative resection of AAV.

Methods: We retrospectively reviewed data for clinicopathological outcome of 47 patients diagnosed with AAV that had underwent a PD. Overall survival probabilities were obtained using the Kaplan-Meier estimate method and a Cox proportional hazards model.

Results: Forty-five patients underwent LPD (laparoscopic pancreatoduodenectomy) and two patients underwent PD. The patient group was composed of 31 males (66%) and 16 females (34%) with a mean age of 65(34-91)years. We selected 45 patients for long-term survival analysis. One- and three-year overall survival rates after resection were 97.6% and 58.9% respectively. The median survival was 37.7 months for the intestinal-type and 26.9 months in pancreatobiliary-type ampullary tumors. Serum carbohydrate antigen (CA) 19-9 greater than 37 U/ml (HR 0.140, P = 0.007), perineural invasion (HR 0.141, P = 0.003), and classification as pancreatobiliary-type (HR 6.633, P = 0.006) were independently associated with poor survival. Serum carcinoembryonic antigen (CEA) greater than 5 µg/ml (P = 0.031), serum CA 19-9 greater than 37 U/ml (P = 0.002), tumor sizes greater than 2.5cm (P=0.002), and positive perineural invasion (P=0.003) were all associated with a poor prognosis in the histopathological subgroup. Serum CA 19-9 greater than 37 U/ml (P=0.002) and positive perineural invasion (P=0.001) were significantly associated with poor survival in of patients with intestinal-type ampullary tumors. Serum CEA greater than 5 µg/ml (P=0.013) and tumor sizes greater than 2.5cm (P=0.002) were significantly associated with poor survival in patients with pancreatobiliary-type ampullary tumors.

Conclusions: Pancreatobiliary-type ampullary tumors were associated with poor survival. Serum CA 19-9 in the intestinal-type and CEA in the pancreatobiliary-type were significantly associated with poor survival. Ajuvant chemotherapy could not predict the survival of AAV patients.
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http://dx.doi.org/10.3389/fonc.2021.616108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930557PMC
February 2021

Adaptive Control and Application for Nonlinear Systems With Input Nonlinearities and Unknown Virtual Control Coefficients.

IEEE Trans Cybern 2021 Mar 4;PP. Epub 2021 Mar 4.

This article is devoted to an adaptive tracking control problem for nonlinear systems with input deadzone and saturation, whose virtual control coefficients include the known and unknown terms. A novel smooth function is first introduced to approximate the input nonlinearities. By utilizing an auxiliary variable and the Nussbaum gain technique, an improved real control signal is constructed to handle the uncertainties of the virtual control coefficients and input nonlinearities. Furthermore, an adaptive tracking controller is constructed and applied to the attitude control of a quadrotor, which guarantees the boundedness of all the signals in the resulting closed-loop system. Finally, both stability analysis and simulation results validate the effectiveness of the developed control strategy.
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http://dx.doi.org/10.1109/TCYB.2021.3054373DOI Listing
March 2021

Deep exploration of PARP inhibitors in breast cancer: monotherapy and combination therapy.

J Int Med Res 2021 Feb;49(2):300060521991019

Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, People's Republic of China.

Objective: Nearly 5% of patients with breast cancer carry germline mutations, which are more common in triple-negative breast cancer (TNBC). Previous clinical trials demonstrated the therapeutic efficacy of poly (ADP-ribose) polymerase inhibitors (PARPis) against -mutated metastatic breast cancer. The current study conducted a systemic review and meta-analysis of the clinical efficiency and safety of PARPis, either alone or combined with chemotherapy, in patients with TNBC.

Methods: We searched PubMed, EMBASE, and ClinicalTrials.gov to identify randomized controlled trials comparing PARPi therapy with chemotherapy, and comparisons of chemotherapy plus PARPis with chemotherapy alone were included. The study endpoints included the clinical response, progression-free survival, and adverse event rates.

Results: PARPi therapy was revealed to improve progression-free survival in patients with advanced breast cancer, either alone or in combination with chemotherapy. Subgroup analysis illustrated that patients with mutant and mutant 2 and those who had not been treated with platinum-based agents could specifically benefit from PARPis.

Conclusion: PARPi monotherapy can significantly improve clinical outcomes in patients with advanced breast cancer, especially those with TNBC, those who had not previously received platinum therapy, and those with mutant . PARPis combined with chemotherapy represent new treatment options for patients with advanced cancer.
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http://dx.doi.org/10.1177/0300060521991019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164563PMC
February 2021

Accumulation of Anthocyanins and Other Phytochemicals in American Elderberry Cultivars during Fruit Ripening and its Impact on Color Expression.

Plants (Basel) 2020 Dec 7;9(12). Epub 2020 Dec 7.

Department of Food Science and Technology, The Ohio State University, 2015 Fyffe Rd, Columbus, OH 43210, USA.

American elderberry () is a plant native to North America with anthocyanin-rich fruits. Our objective was to investigate the effects of cultivar and ripeness on the phytochemical characteristics of its fruits and the corresponding color performance. Cultivars 'Adams', 'Johns', 'Nova', 'Wyldewood', and 'York' were examined for their °Brix, pH, anthocyanin (pH-differential method), and phenolic content (Folin-Ciocalteau method). Extract composition were analyzed by uHPLC-PDA-MS/MS. Color and spectra were determined using a plate reader. All characteristics evaluated were significantly affected by ripeness and cultivar, except for °Brix and total phenolic content, which did not vary significantly among cultivars. Most anthocyanins (63-72%) were acylated with -coumaric acid, with cyanidin-3-(trans)-coumaroylsambubioside-5-glucoside the most predominant. The proportion of acylated anthocyanins was the only characteristic evaluated that decreased during ripening (from 80 to 70%). Extract from fully-ripened fruits exhibited red ( ~520 nm) and blue hues ( ~600 nm) at acidic and alkaline pH, respectively. Extracts from half-ripe fruit rendered yellowish tones and overall dull color. C-18 semi-purified extracts displayed higher color saturation (smaller L* and larger C*) than crude extracts. The vibrant and broad color expression of fully-ripened fruit extract, especially after C-18 purification, suggests this North American native plant as a promising natural colorant source.
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http://dx.doi.org/10.3390/plants9121721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762286PMC
December 2020

Laparoscopic pancreaticodoudenectomy: An excellent approach in elderly patients, a multicenter, comparative study.

Medicine (Baltimore) 2020 Sep;99(38):e22175

Zhejiang University, School of Medicine.

Background: Management of malignant diseases in elderly patients has become a global clinical issue because of increased life expectancy worldwide. Advancements in surgical techniques and perioperative management have reduced age-related contraindications for LPD. Past articles have reported that elderly patients undergoing laproscopic pancreatoduodenectomy (LPD) are at an increased risk compared to younger patients. The aim of this article is to compare a multicenter center risk of LPD in elderly and nonelderly patients.

Methods: Retrospective review (n = 237) of perisurgical outcomes in patients undergoing LPD during the months of September 2012 to December 2017. Outcomes in elderly patients (aged ≥75 years) were compared with those in nonelderly patients.

Results: Transfer to ICU was more frequent in elderly patients (odds ratio [OR] 6.49, P = .001) and the mean hospital stay was longer (21.4 days compared with 16.6 days), (P = .0033) than for nonelderly patients. There was no statistically significant difference in operation time (P = .494), estimated blood loss (P = .0519), blood transfusion (P = .863), decreased gastric emptying (P = .397), abdominal pain (P = .454), food intake (P = .241), time to self-ambulation (P = 1), reoperation (P = .543), postoperative pancreatic fistula (POPF) grade A (P = .454), POPF grade B (P = .736), POPF grade C (P = .164), hemorrhage (P = .319), bile leakage (P = .428), infection (P = .259), GI bleeding (P = .286), morbidity (P = .272) or mortality (P = .449) between the 2 groups.

Conclusions: Elderly patients who underwent LPD in this study had good overall outcomes after LPD that were similar to young patients. The perioperative and long-term outcomes of LPD are not worse. Rates of ICU admission and hospital stays increased in elderly patients undergoing LPD when compared with nonelderly ones. LPD can be performed on elderly patients with similar outcomes as younger patients; therefore, age itself should not be a contraindication for LPD for pancreatic cancer, but it suggests that elderly patients with comorbidities should be more stringently selected for surgery.
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http://dx.doi.org/10.1097/MD.0000000000022175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505399PMC
September 2020

The UTP-glucose-1-phosphate uridylyltransferase of Brucella melitensis inhibits the activation of NF-κB via regulating the bacterial type IV secretion system.

Int J Biol Macromol 2020 Dec 19;164:3098-3104. Epub 2020 Aug 19.

State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun 130112, China; Jilin Academy of Agricultural Sciences, Changchun 130033, China. Electronic address:

UDP-glucose pyrophosphorylase (UGPase) is an important pyrophosphatase that reversibly catalyzes the synthesis of UDP-glucose during glucose metabolism. We previously found that the deletion of UGPase may affect structure, growth, the virulence of Brucella, and the activation of cellular NF-κB. However, the exact mechanism of activation of NF-κB regulated by Brucella UGPase is still unclear. Here, we found for the first time that UGPase can regulate the expression of virB proteins (virB3, virB4, virB5, virB6, virB8, virB9, virB10, and virB11) of type IV secretion system (T4SS) as well as effectors (vceC, btpA, btpB, ricA, bspB, bspC, and bspF) of Brucella by promoting the expression of ribosomal S12 protein (rpsL), BMEI1825, and quinone of 2,4,5-trihydroxyphenylalanine (topA) proteins, and further inhibits the activation of cellular NF-κB and affects the virulence of Brucella. Our findings provide new insights into the mechanism used by Brucella to escape the immune recognition, which is expected to be of great value in the designing of Brucella vaccines and the screening of drug targets.
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http://dx.doi.org/10.1016/j.ijbiomac.2020.08.134DOI Listing
December 2020

Optimal Laparoscopic Management and Oncological Outcomes of Gastrointestinal Stromal Tumors in Duodenum: Pancreaticoduodenectomy or Pancreas-Sparing Duodenectomy?

Cancer Manag Res 2020 19;12:4725-4734. Epub 2020 Jun 19.

Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang Province, People's Republic of China.

Background: Gastrointestinal stromal tumors (GIST) of the duodenum are rarely reported and optimal minimally invasive management has not been well proposed. Pancreaticoduodenectomy and different types of pancreas-sparing duodenectomy can be chosen; however, which to choose and its corresponding clinical outcomes and oncological concerns remain controversial.

Patients And Methods: Patients diagnosed with GIST of duodenum underwent laparoscopic pancreaticoduodenectomy (L-PD) or pancreas-sparing duodenectomy (L-PSD) in Zhejiang Provincial People's Hospital were enrolled. All prospectively maintained data were analyzed retrospectively. Patients were grouped into the L-PD group or the L-PSD group, and the clinical outcomes and oncological outcomes were analyzed.

Results: Between June 2013 and March 2019, a total of 22 patients (11 males/11 females) underwent surgical management, including 13 L-PDs and 9 L-PSDs. The average age was 58.2±9.5 year-old (median 60.5 year-old). The most common presentations were GI bleeding (54.5%) and abdominal discomfort (27.2%), and the dominant lesion located in the second portion of duodenum (59.1%). Compared with L-PD group, L-PSD group showed much shorter operation time (364.2±58.7min vs. 230.0±12.3min, P<0.001), less blood loss (176.9±85.7mL vs. 61.1±18.2min, P<0.001), faster recovery to off-bed (2.6±1.3d vs. 1.1±0.3d, P=0.003), anus flatus (4.5±1.0d vs. 2.4±0.5d, P<0.001) and liquid intake (4.9±1.3d vs. 2.3±0.5d, P<0.001). Lymph node retrieval was much less in L-PSD, but no lymph node metastasis was observed in any patients. L-PSD had much Lower morbidity of both minor (Grade I/II) and major (III/IV/V) complications than that of L-PD (11.1% vs. 61.6%, P=0.02), resulting in shorter hospital stays (10.9±3.8d vs. 20.6±11.1d, P=0.021) and less total cost (76,972.4±11,614.8yuan vs 125,628.7±46,356.8yuan, P=0.006). The median follow-up was 42 months (range from 12 to 82months) without loss. Only 1 L-PD patient suffered hepatic metastasis 36months after surgery, and given sunitinib to stabilize the disease, none of the rest observed recurrence or metastasis.

Conclusion: For GIST located opposite the major papilla, L-PSD showed comparable safety and oncological benefits when compared to L-PD, with shorter operation time, less blood loss and much faster recovery time, resulting in much less total cost. L-PSD should be applied in selected patients with experienced hands.
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http://dx.doi.org/10.2147/CMAR.S254972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310982PMC
June 2020

van der Waals force layered multiferroic hybrid perovskite (CHNH)CuCl single crystals.

Phys Chem Chem Phys 2020 Feb 11;22(7):4235-4239. Epub 2020 Feb 11.

Hubei Key Laboratory of Plasma Chemistry and Advanced Materials, Wuhan Institute of Technology, No. 206 Guanggu 1st Road, Wuhan 430205, China.

In inorganic-organic perovskites, the three-dimensional arrangement of the organic group results in more subtle balance of charge, spin and space, thereby providing an attractive route toward new multiferroics. Here we report the existing of multiple ferroic orderings in inorganic-organic layered perovskites with relative strong hydrogen bond ordering of the organic chains intra plane. In addition, the inter plane in perovskite is stacking via van der Waals force. However, such magnetoelectric coupling properties for this compound have not been reported since it is difficult to characterize the properties in single crystals since most of the hybrid perovskites are usually deliquescent and unstable when exposed to air. To deal with these problems, we synthesized a (CHNH)CuCl single crystal by using a simple evaporation technique, and demonstrated ferroelectric, magnetic and magneto-electric properties of (CHNH)CuCl. The internal hydrogen bonding of easily tunable organic unit combined with 3d transition-metal layers in such hybrid perovskites make (CHNH)CuCl a multiferroic crystal with magnetoelectrical coupling and offer an new way to engineer multifunctional multiferroic.
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http://dx.doi.org/10.1039/c9cp05976hDOI Listing
February 2020

In Operando Calorimetric Measurements for Activated Carbon Electrodes in Ionic Liquid Electrolytes under Large Potential Windows.

ChemSusChem 2020 Mar 29;13(5):1013-1026. Epub 2020 Jan 29.

Mechanical and Aerospace Engineering Department, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, CA, 90095, USA.

This study aims to investigate the effect of the potential window on heat generation in carbon-based electrical double layer capacitors (EDLCs) with ionic-liquid (IL)-based electrolytes using in operando calorimetry. The EDLCs consisted of two identical activated-carbon electrodes with either neat 1-butyl-1-methylpyrrolidinium bis(trifluoromethane-sulfonyl)imide ([Pyr ][TFSI]) electrolyte or 1.0 m [Pyr ][TFSI] in propylene carbonate (PC) as electrolyte. The instantaneous heat generation rate at each electrode was measured under galvanostatic cycling for different potential windows ranging from 1 to 4 V. First, the heat generation rates at the positive and negative electrodes differed significantly in neat IL owing to the differences in the ion sizes and diffusion coefficients. However, these differences were minimized when the IL was diluted in PC. Second, for EDLC in neat [Pyr ][TFSI] at high potential window (4 V), a pronounced endothermic peak was observed at the beginning of the charging step at the positive electrode owing to TFSI intercalation in the activated carbon. On the other hand, for EDLC in 1.0 m [Pyr ][TFSI] in PC at potential window above 3 V, an endothermic peak was observed only at the negative electrode owing to the decomposition of PC. Third, for both neat and diluted [Pyr ][TFSI] electrolytes, the irreversible heat generation rate increased with increasing potential window and exceeded Joule heating. This was attributed to the effect of potential-dependent charge redistribution resistance. A further increase in the irreversible heat generation rate was observed for the largest potential windows owing to the degradation of the PC solvent. Finally, for both types of electrolyte, the reversible heat generation rate increased with increasing potential window because of the increase in the amount of ion adsorbed/desorbed at the electrode/electrolyte interface.
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http://dx.doi.org/10.1002/cssc.201903011DOI Listing
March 2020

Laparoscopic versus open pancreaticoduodenectomy for pancreatic ductal adenocarcinoma: a propensity score matching analysis.

Cancer Commun (Lond) 2019 10 28;39(1):66. Epub 2019 Oct 28.

Department of General Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Xuhui District, Shanghai, 200032, P. R. China.

Background: A growing body of evidence supports the use of laparoscopic pancreaticoduodenectomy (LPD) as an efficient and feasible surgical technique. However, few studies have investigated its applicability in pancreatic ductal adenocarcinoma (PDAC), and the long-term efficacy of LPD on PDAC remains unclear. This study aimed to compare the short- and long-term outcomes between LPD and open pancreaticoduodenectomy (OPD) for PDAC.

Methods: The data of patients who had OPD or LPD for PDAC between January 2013 and September 2017 were retrieved. Their postoperative outcomes and survival were compared after propensity score matching.

Results: A total of 309 patients were included. After a 2:1 matching, 93 cases in the OPD group and 55 in the LPD group were identified. Delayed gastric emptying (DGE), particularly grade B/C DGE, occurred less frequently in the LPD group than in the OPD group (1.8% vs. 36.6%, P < 0.001; 1.8% vs. 22.6%, P = 0.001). The overall complication rates were significantly lower in the LPD group than in the OPD group (49.1% vs. 71.0%, P = 0.008), whereas the rates of major complications were similar (10.9% vs. 14.0%, P = 0.590). In addition, the median overall survival was comparable between the two groups (20.0 vs. 18.7 months, P = 0.293).

Conclusion: LPD was found to be technically feasible with efficacy similar to OPD for patients with PDAC.
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http://dx.doi.org/10.1186/s40880-019-0410-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819395PMC
October 2019

Event-triggered adaptive tracking control for uncertain nonlinear systems based on a new funnel function.

ISA Trans 2020 Apr 23;99:130-138. Epub 2019 Sep 23.

School of Information and Electrical Engineering, Shandong Jianzhu University, Jinan, PR China. Electronic address:

This paper focuses on the problem of event-triggered funnel control for strict-feedback nonlinear systems with unknown parameters. For the first time, an adjustable funnel function is proposed, whose parameters can be adjusted online according to the change of tracking error. Furthermore, based on event-triggered control, an adaptive event-triggered funnel controller is constructed, which guarantees that all the signals in the closed-loop system are bounded. Besides, the output tracking error is further optimized and always falls within an adjustable funnel which has a faster convergence. Meanwhile, the Zeno behavior also is avoided. Simulation results demonstrate the effectiveness of the developed controller.
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http://dx.doi.org/10.1016/j.isatra.2019.09.015DOI Listing
April 2020

Laparoscopic pancreaticoduodenectomy versus open pancreaticoduodenectomy for pancreatic ductal adenocarcinoma: oncologic outcomes and long-term survival.

Surg Endosc 2020 05 17;34(5):1948-1958. Epub 2019 Jul 17.

Department of Medical Oncology, Zhejiang Province People's Hospital, No.158 Shangtang Road, Hangzhou, 310000, Zhejiang, People's Republic of China.

Objective: The study aimed to compare the oncologic outcomes and long-term survival of laparoscopic pancreaticoduodenectomy (LPD) and open pancreaticoduodenectomy (OPD) for patients diagnosed with pancreatic ductal adenocarcinoma (PDAC).

Background: Substantial evidence demonstrated that LPD is technically safe and feasible with perioperative outcomes equivalent to that of OPD. However, for patients with malignancy, especially PDAC, the oncologic outcomes and long-term survival of patients who underwent LPD remains to be elucidated.

Methods: Studies on LPD for the treatment of PDAC published before December 25, 2018 were searched online. The oncologic outcomes (e.g., numbers of lymph nodes retrieved, negative margin (R0) resection), and long-term survival (postoperative survival from 1 to 5 year) of LPD were compared to that of ODP.

Results: After screening 1507 studies, six comparative cohort studies, which reported the oncologic outcomes and long-term survival of patients with PDAC were included. No significant difference was found between LPD and OPD regarding lymph nodes harvested (OR 1.96, 95% CI - 1.17 to 5.09, p = 0.22), R0 rate (OR 1.44, 95% CI 1.00 to 2.06, p = 0.05), number of positive lymph nodes (OR - 0.44, 95% CI - 1.06 to 0.17, p = 0.16), rate of adjuvant treatment (OR 1.04, 95% CI 0.68 to 1.59, p = 0.86) and time to adjuvant treatment (OR - 6.21, 95% CI - 16.00 to 3.59, p = 0.21). LPD showed similar 1-year (OR 1.20, 95% CI 0.87 to 1.65, p = 0.28), and 2-year survival (OR 1.25, 95% CI 0.94 to 1.66, p = 0.13) to that of OPD. The 3-year (OR 1.50, 95% CI 1.12 to 2.02, p = 0.007), 4-year (OR 1.73, 95% CI 1.02 to 2.93, p = 0.04), and 5-year survival (OR 2.11, 95% CI 1.35 to 3.31, p = 0.001) were significantly longer in LPD group.

Conclusion: For the treatment of PDAC, the oncologic outcomes of LPD were equivalent to that of OPD; LPD seemed promising regarding the postoperative long-term survival.
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http://dx.doi.org/10.1007/s00464-019-06968-8DOI Listing
May 2020

Hydroxychloroquine enhances the antitumor effects of BC001 in gastric cancer.

Int J Oncol 2019 Aug 12;55(2):405-414. Epub 2019 Jun 12.

Department of Pharmacy, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, P.R. China.

Gastric cancer is an important cancer type worldwide, the anti‑angiogenic agent BC001 can target the vascular endothelial growth factor receptor 2 (VEGFR2), and significantly suppresses the growth of gastric cancer BGC823 cells in vitro and in vivo. However, numerous results indicated that antiangiogenic drugs could induce autophagy, and the inhibition of autophagy enhanced the anticancer effects of antiangiogenic agents. In the present study, hydroxychloroquine (HCQ), an inhibitor of autophagy, enhanced the antiproliferative and proapoptotic effects of BC001 in vitro. Furthermore, HCQ enhanced the antitumor effects of BC001 on BGC823 xenograft tumors in vivo. Of note, BC001 neither induced nor inhibited autophagy. RNA‑sequencing results revealed that HCQ regulated autophagy or lysosomal‑associated genes, such as tumor protein p53‑inducible nuclear protein 1, interleukin (IL)1B, tumor necrosis factor (TNF), Mediterranean fever, ubiquitin specific peptidase 36, IL6, neuraminidase (NEU)1, ATP‑binding cassette subfamily A member 1, proprotein convertase subtilisin/kexin type 9, myelin basic protein and NEU3. Importantly, HCQ was determined to affect multiple pathways, including 'negative regulation of endothelial cell proliferation', 'blood vessel remodeling', 'cell surface receptor signaling pathways' and 'notch receptor processing' associated with 'signal transduction', 'cancers' and 'immune system', through regulating C‑X‑C motif chemokine ligand 8, TNF, IL6, intercellular adhesion molecule 1 and FOS genes. In summary, HCQ was proposed to enhance the anticancer effects of BC001 in gastric cancer via complex mechanisms.
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http://dx.doi.org/10.3892/ijo.2019.4824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615922PMC
August 2019

Cognitive Neural Mechanism of Sports Competition Pressure Source.

Transl Neurosci 2019 25;10:147-151. Epub 2019 Apr 25.

Department of sports, Chongqing Jiaotong University, Chongqing 400074, China.

At sports events, the athletes by the pressure source is varied, based on the stress status of athletes, many athletes stress related experts at home and abroad to design questionnaire, questionnaire and sports events for athletes with often life process of in-depth and meticulous investigation, has formed the one whole set athletes pressure source of cognitive neuroscience assessment system, sports competition for athlete's "escort". By participating in state general administration of sports scientific research project " management system of athlete competition pressure cognitive neuroscience" the development of using psychological pressure on athletes' source data, the application of natural language processing and machine learning technology research these data, mainly using clustering algorithm and recommendation algorithm, thus forming pressure source research results are applied in sports competitions.
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http://dx.doi.org/10.1515/tnsci-2019-0025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534052PMC
April 2019

Design and synthesis of novel tellurodibenzoic acid compounds as kidney-type glutaminase (KGA) inhibitors.

Bioorg Med Chem Lett 2019 07 24;29(13):1673-1676. Epub 2019 Apr 24.

College of Pharmaceutical Science, Institute of Drug Development & Chemical Biology (IDD &CB), Collaborative Innovation Center of Yangtza River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, PR China. Electronic address:

Organotellurium compounds have been reported as an immune-modulator sensitizing chemotherapeutics. Herein, we report the design and synthesis of a series of novel tellurodibenzoic acids as mimics of diphenylarsenic acid (DPAA) and potential selective KGA inhibitors. Representative compound 3B exhibited potent inhibition of KGA and glutamine-dependent HCT-116 cells. Stability experiments indicated that 3B has excellent stability under acidic (HCOOH), basic (NH·HO) and oxidative (HO) conditions, but reacts with β-ME, DTT and lysine which suggested that compound 3B may interact with cysteine or lysine residues. Moreover, molecular docking disclosed that compound 3B binds to the allosteric site of the GAC tetramer containing Arg-Lys-Leu-Phe-Tyr-Glu, which helped to rationalize the SAR and further design and optimization. Taken together, compound 3B could be used as a starting point for the development of new KGA inhibitors.
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http://dx.doi.org/10.1016/j.bmcl.2019.04.032DOI Listing
July 2019

Who Can Get More Benefits? Effects of Mindfulness Training in Long-Term and Short-Term Male Prisoners.

Int J Offender Ther Comp Criminol 2019 10 2;63(13):2318-2337. Epub 2019 May 2.

1 Nanjing Normal University, China.

The aim of the present study was to examine the effects of a 6-week mindfulness training program on mental health, anxiety, depression, aggression, sleep quality, mood states, total mood disturbance, and perceived stress among male Chinese prisoners, and to explore whether the intervention effects differed in long-term and short-term prisoners. Eighty-three male prisoners completed the study, including 39 in the mindfulness training group and 44 in the waitlist control group. Results showed that, compared with the waitlist control group, mindfulness training group showed a significant improvement in mindfulness level ( < .0l), Symptom Checklist-90 (SCL-90; < .00l), aggression ( < .05), sleep quality ( < .05), and total mood disturbance ( < .0l). Moreover, compared with the short-term prisoners, mindfulness training was more effective on the long-term prisoners in mindfulness level ( < .05), SCL-90 ( < .001), anxiety ( < .05), depression ( < .05), aggression ( < .05), total mood disturbance ( < .0l), and perceived stress ( < .0l). Given the study's innovation, we discussed its significance and limitations.
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http://dx.doi.org/10.1177/0306624X19846771DOI Listing
October 2019

Differential Susceptibility of Wild and Cultivated Blueberries to an Invasive Frugivorous Pest.

J Chem Ecol 2019 Mar 15;45(3):286-297. Epub 2018 Dec 15.

Laboratory of Evolutionary Entomology, Institute of Biology, University of Neuchâtel, Emile Argand 11, Case postale 158, 2009, Neuchâtel, Switzerland.

Highbush blueberry is a crop native to the northeast USA that has been domesticated for about 100 years. This study compared the susceptibility of wild and domesticated/cultivated highbush blueberries to an invasive frugivorous pest, the spotted wing drosophila (Drosophila suzukii). We hypothesized that: 1) cultivated fruits are preferred by D. suzukii for oviposition and better hosts for its offspring than wild fruits; and, 2) wild and cultivated fruits differ in physico-chemical traits. Fruits from wild and cultivated blueberries were collected from June through August of 2015 and 2016 from 10 to 12 sites in New Jersey (USA); with each site having wild and cultivated blueberries growing in close proximity. The preference and performance of D. suzukii on wild and cultivated blueberries were studied in choice and no-choice bioassays. In addition, we compared size, firmness, acidity (pH), total soluble solids (°Brix), and nutrient, phenolic, and anthocyanin content between wild and cultivated berries. In choice and no-choice bioassays, more eggs were oviposited in, and more flies emerged from, cultivated than wild blueberries. Cultivated fruits were 2x bigger, 47% firmer, 14% less acidic, and had lower °Brix, phenolic, and anthocyanin amounts per mass than wild fruits. Levels of potassium and boron were higher in cultivated fruits, while calcium, magnesium, and copper were higher in wild fruits. These results show that domestication and/or agronomic practices have made blueberries more susceptible to D. suzukii, which was associated with several physico-chemical changes in fruits. Our study documents the positive effects of crop domestication/cultivation on an invasive insect pest.
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http://dx.doi.org/10.1007/s10886-018-1042-1DOI Listing
March 2019

Mink Circovirus Can Infect Minks, Foxes and Raccoon Dogs.

Virol Sin 2018 Dec 4;33(6):561-564. Epub 2018 Dec 4.

Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Jilin University, Changchun, 130062, China.

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http://dx.doi.org/10.1007/s12250-018-0059-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335222PMC
December 2018

Mink Circovirus Can Infect Minks, Foxes and Raccoon Dogs.

Virol Sin 2018 Dec 4;33(6):561-564. Epub 2018 Dec 4.

Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Jilin University, Changchun, 130062, China.

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http://dx.doi.org/10.1007/s12250-018-0059-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335222PMC
December 2018

Laparoscopic pancreaticoduodenectomy in A-92-older Chinese patient for cancer of head of the pancreas: A Case report.

Medicine (Baltimore) 2017 Jan;96(3):e5962

Department of General Surgery, School of Medicine, Zhejiang University Department of General Surgery, Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital, Hangzhou Department of Hepatobiliary Surgery, Yinzhou Hospital Affiliated to Medical School of Ningbo University, Ningbo, Zhejiang Province, China.

Introduction: Laparoscopic pancreaticoduodenectomy (LPD) is one of the most complex gastrointestinal procedures performed in laparoscopic abdominal surgery. However, the concern for elderly undergoing LPD remains. To the best of our knowledge, there are no reports describing LPD for A-92-older patient. This study aimed to share the experience of a tertiary pancreatic center and confirm the safety, feasibility of LPD for the elderly.

Method: The patient had complained of 6-months history of abdominal discomfort and progressive jaundice. Abdominal computed tomography CT/MR imaging revealed a 3 × 3 cm solid hypovascular mass in the head of the pancreas. LPD was successfully performed after multidisciplinary team (MDT). Operation time was 450 minutes, and blood loss was 120 mL. Histological examination of the resected specimen confirmed the diagnosis of pancreatic ductal adenocarcinoma (PDAC).

Outcomes: The patient was discharged on POD13 following an uneventful postoperative period. She was followed up 4 months without any sign of recurrence.

Conclusion: LPD can be performed safely in patients of any age who are fit for surgery in specialist centers.
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http://dx.doi.org/10.1097/MD.0000000000005962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5279107PMC
January 2017

Frugivory by Brown Marmorated Stink Bug (Hemiptera: Pentatomidae) Alters Blueberry Fruit Chemistry and Preference by Conspecifics.

Environ Entomol 2016 10 22;45(5):1227-1234. Epub 2016 Aug 22.

Department of Entomology, Rutgers University, New Brunswick, NJ 08901,

The brown marmorated stink bug, Halyomorpha halys (Stål), is an invasive pest from Asia that feeds on many agricultural crops in the United States, including blueberries. Yet, the effects of H. halys feeding on fruit chemistry and induced resistance to insects remain unknown. Here we hypothesized that frugivory by H. halys changes fruit chemical composition, which in turn affects insect feeding behavior. In field experiments, blueberry fruit was either mechanically injured or injured by 0 (control), 2, 5, or 10 H. halys Total soluble solids (°Brix) and anthocyanin and phenolic content in injured and uninjured fruits, as well as their effects on feeding behavior by conspecifics, were measured subsequently in the laboratory. Results showed lower °Brix values in injured fruit as compared with uninjured fruit. Fruit injured by 2 and 5 H. halys also had 32 and 20% higher total phenolics, respectively, than the uninjured controls. The proportions of the anthocyanins derived from delphinidin, cyanidin, and petunidin increased, whereas those from malvidin decreased, in fruit after mechanical wounding and frugivory by H. halys In dual-choice tests, H. halys fed more often on uninjured fruit than those previously injured by conspecifics. These results show that frugivory by H. halys reduces the amounts of soluble solids, alters anthocyanin ratios, and increases levels of phenolics, and, as a result, injured fruits were a less preferred food source for conspecifics. To our knowledge, this is the first study to investigate the effects of frugivory on fruit chemistry and induced fruit resistance against a fruit-eating herbivore.
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http://dx.doi.org/10.1093/ee/nvw110DOI Listing
October 2016

Analysis of learning curve for laparoscopic pancreaticoduodenectomy.

J Vis Surg 2016 18;2:145. Epub 2016 Aug 18.

Department of General Surgery, School of Medicine, Zhejiang University, Hangzhou 310058, China.

Background: Laparoscopic pancreaticoduodenectomy (LPD) may have potential minimal invasive advantages for selected patients in limited center. However, few studies analyzed the learning curve. This study aimed to analyze the learning curve of this procedure at a large volume set, and share our experience to surmount it.

Methods: All prospectively maintained data of the consecutive LPDs was reviewed retrospectively. The procedures were performed by single surgeon. Patients were divided into four groups according to staged approach with different focuses: Group A (the first 30 patients), Group B (the second 30 patients), Group C (the third 30 patients), and Group D (the fourth and last 30 patients). And the changes of outcomes during different learning periods were analyzed.

Results: Between September 2012 and July 2015, 120 patients underwent LPD. One hundred and eleven of them underwent totally LPD, and 9 patients underwent laparoscopic assisted pancreaticoduodenectomy (LAPD). The mean operative time (OT), mean blood loss and average length of hospital stay (LOS) was 359.8±57.6 min, 169.7±152.6 mL and 17.0±9.8 d respectively. A total of 42 (35%) patients developed morbidity with no mortality. The mean overall OT tended to decrease from 370.2±52.8 min in Group A to 342.0±73.1 min in Group D with the accumulating experience of the surgeon. Moreover, mean OT of pancreatojejunostomy and choledochojejunostomy also tended to decrease from 55.0±8.7, 39.8±11.7 min in Group A to 43.6±7.6, 27.7±11.8 min in Group D respectively. Meanwhile, the clinical outcomes tended to get better. Mean blood loss, morbidity and LOS decreased from 219.3±147.9 mL, 43.3%, 18.7±10.0 d in Group A to 140.1±73.6 mL, 23.3%, 14.4±6.2 d in Group C respectively except for Group D.

Conclusions: Routine practice of the LPD procedure was feasible and safe. Gained experience can improve clinical outcomes in 30 to 60 operations by overcoming the learning curve.
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http://dx.doi.org/10.21037/jovs.2016.07.25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637755PMC
August 2016

Laparoscopic duodenum-preserving pancreatic head resection: A case report.

Medicine (Baltimore) 2016 Aug;95(32):e4442

Department of General Surgery, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China Department of General Surgery, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang Province, China.

Background: Solid pseudopapillary neoplasms (SPNs) of the pancreas are uncommon neoplasms and are potentially malignant. Complete resection is advised due to rare recurrence and metastasis. Duodenum-preserving pancreatic head resection (DPPHR) is indicated for SPNs located in the pancreatic head and is only performed using the open approach. To the best of our knowledge, there are no reports describing laparoscopic DPPHR (LDPPHR) for SPNs.

Methods: Herein, we report a case of 41-year-old female presented with a 1-week history of epigastric abdominal discomfort, and founded an SPN of the pancreatic head by abdominal computed tomography/magnetic resonance, who was treated by radical LDPPHR without complications, such as pancreatic fistula and bile leakage. Histological examination of the resected specimen confirmed the diagnosis of SPN.

Results: The patient was discharged 1 week after surgery following an uneventful postoperative period. She was followed up 3 months without readmission and local recurrence according to abdominal ultrasound.

Conclusion: LDPPHR is a safe, feasible, and effective surgical procedure for SPNs.
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http://dx.doi.org/10.1097/MD.0000000000004442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985314PMC
August 2016

[Laparoscopic gastrectomy for gastric stump cancer: analysis of 7 cases].

Zhonghua Wei Chang Wai Ke Za Zhi 2016 May;19(5):553-6

Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital, Hangzhou 310014, China.

Objective: To evaluate the safety and feasibility of laparoscopic gastrectomy for gastric stump cancer.

Methods: Clinical and follow-up data of 7 patients who underwent laparoscopic gastrectomy for gastric stump cancer in our department from January 2008 to July 2015 were analyzed retrospectively.

Results: There were 5 male and 2 female patients, with a mean age of (62.1±10.7) years. Initial gastrectomy was performed for gastric cancer in 3 patients and peptic ulceration in 4. The initial surgery was B-II( gastrojejunostomy in 6 patients and Roux-en-Y gastrojejunostomy in 1. Duration between primary gastrectomy and occurrence of gastric stump cancer was ranged from 6-30 years for peptic ulceration, and from 11-15 years for gastric cancer. During the operation, adhesiolysis and exploration to locate the tumor were performed. Following total remnant gastrectomy and lymphadenectomy, intracorporeal anastomosis was accomplished by Roux-en-Y reconstruction. The methods of intracorporeal esophagojejunostomy were end-to-side approach using a circular stapler in 1 patient, side-to-side approach using an endoscopic linear staple in 2 patients, and hand-sewn technique in 4 patients. The operation time was (247.1±17.5) minutes and the intraoperative blood loss was (100.0±30.8) ml without transfusion. The number of retrieved lymph node was 19.1±4.8. The first flatus time, diet resumption time, postoperative hospital stay were (3.3±1.5) days, (3.7±0.8) days, (9.4±2.6) days, respectively. One patient experienced gastrointestinal bleeding that was managed conservatively and ultimately cured. Seven patients were followed up till January 2016. After follow-up from 6 to 38 months, 1 patient died of peritoneal metastasis 17 months after surgery, and 1 patient died of Alzheimer's disease 19 months after surgery. The other 5 patients were still alive without metastasis or recurrence.

Conclusion: Laparoscopic gastrectomy for gastric stump cancer is feasible and safe.
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May 2016

Metal-Carbon Hybrid Electrocatalysts Derived from Ion-Exchange Resin Containing Heavy Metals for Efficient Hydrogen Evolution Reaction.

Small 2016 May 7;12(20):2768-74. Epub 2016 Apr 7.

New Energy Research Institute, School of Environment and Energy, South China University of Technology, Guangzhou Higher Education Mega Center, Guangzhou, 510006, P. R. China.

Transition metal-carbon hybrids have been proposed as efficient electrocatalysts for hydrogen evolution reaction (HER) in acidic media. Herein, effective HER electrocatalysts based on metal-carbon composites are prepared by controlled pyrolysis of resin containing a variety of heavy metals. For the first time, Cr2 O3 nanoparticles of 3-6 nm in diameter homogeneously dispersed in the resulting porous carbon framework (Cr-C hybrid) is synthesized as efficient HER electrocatalyst. Electrochemical measurements show that Cr-C hybrids display a high HER activity with an onset potential of -49 mV (vs reversible hydrogen electrode), a Tafel slope of 90 mV dec(-1) , a large catalytic current density of 10 mA cm(-2) at -123 mV, and the prominent electrochemical durability. X-ray photoelectron spectroscopic measurements confirm that electron transfer occurs from Cr2 O3 into carbon, which is consistent with the reported [email protected] systems. The obtained correlation between metals and HER activities may be exploited as a rational guideline in the design and engineering of HER electrocatalysts.
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http://dx.doi.org/10.1002/smll.201503100DOI Listing
May 2016

Characterization of Al2O3 in High-Strength Mo Alloy Sheets by High-Resolution Transmission Electron Microscopy.

Microsc Microanal 2016 Feb;22(1):122-30

2Henan Engineering Research Center for Wear of Materials,Henan University of Science & Technology,Luoyang 471003,China.

A novel type of alumina (Al2O3)-doped molybdenum (Mo) alloy sheet was prepared by a hydrothermal method and a subsequent powder metallurgy process. Then the characterization of α-Al2O3 was investigated using high-resolution transmission electron microscopy as the research focus. The tensile strength of the Al2O3-doped Mo sheet is 43-85% higher than that of the pure Mo sheet, a very obvious reinforcement effect. The sub-micron and nanometer-scale Al2O3 particles can increase the recrystallization temperature by hindering grain boundary migration and improve the tensile strength by effectively blocking the motion of the dislocations. The Al2O3 particles have a good bond with the Mo matrix and there exists an amorphous transition layer at the interface between Al2O3 particles and the Mo matrix in the as-rolled sheet. The sub-structure of α-Al2O3 is characterized by a number of nanograins in the $\left[ {2\bar{2}1} \right]$ direction. Lastly, a new computer-based method for indexing diffraction patterns of the hexagonal system is introduced, with 16 types of diffraction patterns of α-Al2O3 indexed.
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http://dx.doi.org/10.1017/S1431927615015780DOI Listing
February 2016

[Early experience of laparoscopic pancreaticoduodenectomy on 66 cases].

Zhonghua Wai Ke Za Zhi 2016 Feb;54(2):84-8

School of Medicine, Zhejiang University, Hangzhou 310029, China.

Objective: To evaluate the feasibility and safety of laparoscopic pancreaticoduodenectomy(LPD).

Methods: Data of 66 patients from Sir Run Run Shaw Hospital undergoing LPD from September 2012 to September 2014 were reviewed. There were 44 male and 22 female with the mean age of (58.7±10.3) years and mean body mass index of (23.5±3.9)kg/m(2). Forty-five patients presented the symptoms and four of all had the history of abdominal surgery, including 2 cases of laparoscopic pancreatic surgery.

Results: Of 66 patients underwent laparoscopic procedure, 1 patient underwent LPD combined with right hepatic resection, 1 patient underwent laparoscopic distal gastrectomy with LPD, and 1 patient underwent LPD after laparoscopic distal pancreatectomy. The mean operative time was (367±49) minutes. The mean blood loss was(193±126)ml. The rate of overall postoperative complications was 36.4%(24/66), with 4.5%(3/66) of B or C pancreatic fistula and 7.6% (5/66) of bleeding. The mean postoperative hospital stay was (18.9±12.1) days. Mean tumor size was (3.8±2.3) cm, and the mean number of lymph nodes harvested was (20.3±10.9). Forty-severn patients were diagnosed as pancreatic adenocarcinoma(n=18), cholangiocarcinoma(n=7), ampullary adenocarcinoma(n=21), and gastric cancer(n=1), respectively.

Conclusion: LPD is feasible and safe under the skilled hand.
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http://dx.doi.org/10.3760/cma.j.issn.0529-5815.2016.02.002DOI Listing
February 2016
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