Dr. Yuchen Nan, PhD - University of Maryland

Dr. Yuchen Nan

PhD

University of Maryland

United States

ORCID logohttps://orcid.org/0000-0002-4442-8004

Dr. Yuchen Nan, PhD - University of Maryland

Dr. Yuchen Nan

PhD

Introduction

Primary Affiliation: University of Maryland - United States

Education

Aug 2009 - Aug 2014
University of Maryland at College Park
Ph. D.
Veterinary Medicine
Sep 2007 - Jul 2009
Northwest A and F University
Masters
Veyerinary Medicine

Experience

Sep 2014 - Jan 2015
University of Maryland College Park
Post-docteral
Veterinary Medicine
Aug 2009 - Aug 2014
University of Maryland College Park
Graduate Research Assistant
Veterinary Medicine
Sep 2015
Northwest A & F University

Preventive Veterinary Medicine

Publications

35Publications

858Reads

-Profile Views

7PubMed Central Citations

Chicken Organic Anion-Transporting Polypeptide 1A2, a Novel Avian Hepatitis E Virus (HEV) ORF2-Interacting Protein, Is Involved in Avian HEV Infection.

J Virol 2019 Jun 15;93(11). Epub 2019 May 15.

Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China

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http://dx.doi.org/10.1128/JVI.02205-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532094PMC
June 2019
3 Reads
4.439 Impact Factor

Development of a monoclonal antibody against swine leukocyte antigen (SLA)-DR α chain and evaluation of SLA-DR expression in bone marrow-derived dendritic cells after PRRSV infection.

Vet Immunol Immunopathol 2019 May 11;211:19-24. Epub 2019 Apr 11.

Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, China; Scientific Observing and Experimental Station of Veterinary Pharmacology and Diagnostic Technology, Ministry of Agriculture, Yangling, Shaanxi, 712100, China. Electronic address:

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http://dx.doi.org/10.1016/j.vetimm.2019.04.001DOI Listing
May 2019
1 Read
1.535 Impact Factor

Experimental infection of rabbit with swine-derived hepatitis E virus genotype 4.

Vet Microbiol 2019 Feb 4;229:168-175. Epub 2019 Jan 4.

Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China; Scientific Observing and Experimental Station of Veterinary Pharmacology and Diagnostic Technology, Ministry of Agriculture, Yangling, Shaanxi, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03781135183116
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http://dx.doi.org/10.1016/j.vetmic.2019.01.001DOI Listing
February 2019
22 Reads
2.511 Impact Factor

A Nanobody Targeting Viral Nonstructural Protein 9 Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication.

J Virol 2019 Feb 5;93(4). Epub 2019 Feb 5.

College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China

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http://dx.doi.org/10.1128/JVI.01888-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364029PMC
February 2019
31 Reads
4.440 Impact Factor

Development of luciferase-linked antibody capture assay based on luciferase immunoprecipitation systems for antibody detection of porcine reproductive and respiratory syndrome virus.

BMC Biotechnol 2018 11 16;18(1):73. Epub 2018 Nov 16.

Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, 712100, Shaanxi, China.

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https://bmcbiotechnol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12896-018-0483-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240198PMC
November 2018
30 Reads
2.034 Impact Factor

Recombinant MYH9 protein C-terminal domain blocks porcine reproductive and respiratory syndrome virus internalization by direct interaction with viral glycoprotein 5.

Antiviral Res 2018 08 4;156:10-20. Epub 2018 Jun 4.

Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China; Scientific Observing and Experimental Station of Veterinary Pharmacology and Diagnostic Technology, Ministry of Agriculture, Yangling, Shaanxi, China. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2018.06.001DOI Listing
August 2018
25 Reads
3.940 Impact Factor

Characterization of Three Novel Linear Neutralizing B-Cell Epitopes in the Capsid Protein of Swine Hepatitis E Virus.

J Virol 2018 07 13;92(13). Epub 2018 Jun 13.

Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China

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http://dx.doi.org/10.1128/JVI.00251-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002721PMC
July 2018
7 Reads
4.440 Impact Factor

Avian hepatitis E virus infection of duck, goose, and rabbit in northwest China.

Emerg Microbes Infect 2018 05 2;7(1):76. Epub 2018 May 2.

Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University and Scientific Observing and Experimental Station of Veterinary Pharmacology and Diagnostic Technology, Ministry of Agriculture, China, Shaanxi, 712100, Yangling, China.

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http://dx.doi.org/10.1038/s41426-018-0075-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931602PMC
May 2018
3 Reads

Karyopherin Alpha 6 Is Required for Replication of Porcine Reproductive and Respiratory Syndrome Virus and Zika Virus.

J Virol 2018 05 13;92(9). Epub 2018 Apr 13.

Molecular Virology Laboratory, VA-MD College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA

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http://dx.doi.org/10.1128/JVI.00072-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899184PMC
May 2018
53 Reads
1 Citation
4.440 Impact Factor

Antisense Phosphorodiamidate Morpholino Oligomers as Novel Antiviral Compounds.

Front Microbiol 2018 20;9:750. Epub 2018 Apr 20.

Virginia-Maryland College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland, College Park, MD, United States.

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http://dx.doi.org/10.3389/fmicb.2018.00750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920040PMC
April 2018
6 Reads
3.941 Impact Factor

Interferon Independent Non-Canonical STAT Activation and Virus Induced Inflammation.

Viruses 2018 04 14;10(4). Epub 2018 Apr 14.

Molecular Virology Laboratory, VA-MD College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland, College Park, MD 20742, USA.

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http://dx.doi.org/10.3390/v10040196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923490PMC
April 2018
3.280 Impact Factor

Vaccine Development against Zoonotic Hepatitis E Virus: Open Questions and Remaining Challenges.

Front Microbiol 2018 19;9:266. Epub 2018 Feb 19.

Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, China.

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http://dx.doi.org/10.3389/fmicb.2018.00266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827553PMC
February 2018
3 Reads
3.941 Impact Factor

Interplay between Janus Kinase/Signal Transducer and Activator of Transcription Signaling Activated by Type I Interferons and Viral Antagonism.

Front Immunol 2017 11;8:1758. Epub 2017 Dec 11.

Molecular Virology Laboratory, VA-MD Regional College of Veterinary Medicine, Maryland Pathogen Research Institute, University of Maryland, College Park, MD, United States.

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http://dx.doi.org/10.3389/fimmu.2017.01758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732261PMC
December 2017
3 Reads

Evaluation of recombinant Chinese avian hepatitis E virus (CaHEV) ORF2 and ORF3 proteins for protection of chickens against CaHEV infection.

Vaccine 2017 06 18;35(27):3482-3489. Epub 2017 May 18.

Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling 712100, Shaanxi, PR China; Scientific Observing and Experimental Station of Veterinary Pharmacology and Diagnosis, China Ministry of Agriculture, Yangling 712100, Shaanxi, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2017.05.030DOI Listing
June 2017
117 Reads
2 Citations
3.624 Impact Factor

Rabbit hepatitis E virus is an opportunistic pathogen in specific-pathogen-free rabbits with the capability of cross-species transmission.

Vet Microbiol 2017 Mar 15;201:72-77. Epub 2017 Jan 15.

Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China; Scientific Observing and Experimental Station of Veterinary Pharmacology and Veterinary Biotechnology, Ministry of Agriculture, Yangling, Shaanxi, China. Electronic address:

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http://dx.doi.org/10.1016/j.vetmic.2016.10.029DOI Listing
March 2017
18 Reads
4 Citations
2.511 Impact Factor

Porcine Reproductive and Respiratory Syndrome Virus Antagonizes JAK/STAT3 Signaling via nsp5, Which Induces STAT3 Degradation.

J Virol 2017 Feb 18;91(3). Epub 2017 Jan 18.

Molecular Virology Laboratory, VA-MD College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA

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http://dx.doi.org/10.1128/JVI.02087-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244345PMC
February 2017
10 Reads
4.440 Impact Factor

Heme oxygenase-1 metabolite biliverdin, not iron, inhibits porcine reproductive and respiratory syndrome virus replication.

Free Radic Biol Med 2017 01 28;102:149-161. Epub 2016 Nov 28.

College of Veterinary Medicine, Northwest A&F University, 22 Xinong Road, Yangling, Shaanxi 712100, China; Experimental Station of Veterinary Pharmacology and Veterinary Biotechnology, Ministry of Agriculture, China, 22 Xinong Road, Yangling, Shaanxi 712100, China. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2016.11.044DOI Listing
January 2017
72 Reads
5.740 Impact Factor

Sustaining Interferon Induction by a High-Passage Atypical Porcine Reproductive and Respiratory Syndrome Virus Strain.

Sci Rep 2016 11 2;6:36312. Epub 2016 Nov 2.

Molecular Virology Laboratory, VA-MD College of Veterinary Medicine, University of Maryland, College Park, MD, USA.

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http://dx.doi.org/10.1038/srep36312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090871PMC
November 2016
30 Reads
5.080 Impact Factor

Molecular Biology and Infection of Hepatitis E Virus.

Front Microbiol 2016 7;7:1419. Epub 2016 Sep 7.

Molecular Virology Laboratory, VA-MD College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland, College Park, College Park MD, USA.

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http://dx.doi.org/10.3389/fmicb.2016.01419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013053PMC
September 2016
8 Reads
3.941 Impact Factor

A Linear Surface Epitope in a Proline-Rich Region of ORF3 Product of Genotype 1 Hepatitis E Virus.

Viruses 2016 08 18;8(8). Epub 2016 Aug 18.

Molecular Virology Laboratory, VA-MD College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland, College Park, MD 20742, USA.

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http://dx.doi.org/10.3390/v8080227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997589PMC
August 2016
6 Reads
3.280 Impact Factor

Downregulation of protein kinase PKR activation by porcine reproductive and respiratory syndrome virus at its early stage infection.

Vet Microbiol 2016 May 7;187:1-7. Epub 2016 Mar 7.

Molecular Virology Laboratory, VA-MD Regional College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland, College Park, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.vetmic.2016.03.004DOI Listing
May 2016
10 Reads
2.511 Impact Factor

The Thr to Met substitution of amino acid 118 in hepatitis B virus surface antigen escapes from immune-assay-based screening of blood donors.

J Gen Virol 2016 05 12;97(5):1210-7. Epub 2016 Feb 12.

1​Nanjing Red Cross Blood Center,Nanjing 210003, PRChina.

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http://www.microbiologyresearch.org/content/journal/jgv/10.1
Publisher Site
http://dx.doi.org/10.1099/jgv.0.000427DOI Listing
May 2016
30 Reads
3.183 Impact Factor

MYH9 is an Essential Factor for Porcine Reproductive and Respiratory Syndrome Virus Infection.

Sci Rep 2016 04 26;6:25120. Epub 2016 Apr 26.

Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, China.

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http://dx.doi.org/10.1038/srep25120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845007PMC
April 2016
25 Reads
5.080 Impact Factor

Inhibition of hepatitis E virus replication by peptide-conjugated morpholino oligomers.

Antiviral Res 2015 Aug 15;120:134-9. Epub 2015 Jun 15.

VA-MD College of Veterinary Medicine, University of Maryland, College Park, MD, United States; Maryland Pathogen Research Institute, University of Maryland, College Park, MD, United States. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2015.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502978PMC
August 2015
56 Reads
3.940 Impact Factor

Interferon induction by RNA viruses and antagonism by viral pathogens.

Viruses 2014 Dec 12;6(12):4999-5027. Epub 2014 Dec 12.

Molecular Virology Laboratory, VA-MD College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland, College Park, MD 20742, USA.

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http://dx.doi.org/10.3390/v6124999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276940PMC
December 2014
6 Reads
3.280 Impact Factor

Hepatitis E virus inhibits type I interferon induction by ORF1 products.

J Virol 2014 Oct 6;88(20):11924-32. Epub 2014 Aug 6.

Molecular Virology Laboratory, Virginia-Maryland College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA

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http://dx.doi.org/10.1128/JVI.01935-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178743PMC
October 2014
18 Reads
4.440 Impact Factor

Enhancement of interferon induction by ORF3 product of hepatitis E virus.

J Virol 2014 Aug 21;88(15):8696-705. Epub 2014 May 21.

Molecular Virology Laboratory, Virginia-Maryland Regional College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland

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http://dx.doi.org/10.1128/JVI.01228-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135948PMC
August 2014
14 Reads
4.440 Impact Factor

Enhancing neutralizing antibody production by an interferon-inducing porcine reproductive and respiratory syndrome virus strain.

Vaccine 2013 Nov 21;31(47):5537-43. Epub 2013 Sep 21.

Molecular Virology Laboratory, VA-MD Regional College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland, College Park, MD, USA.

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http://dx.doi.org/10.1016/j.vaccine.2013.09.023DOI Listing
November 2013
83 Reads
3.624 Impact Factor

Variable interference with interferon signal transduction by different strains of porcine reproductive and respiratory syndrome virus.

Vet Microbiol 2013 Oct 30;166(3-4):493-503. Epub 2013 Jul 30.

College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China.

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http://dx.doi.org/10.1016/j.vetmic.2013.07.022DOI Listing
October 2013
22 Reads
2.511 Impact Factor

Porcine reproductive and respiratory syndrome virus Nsp1β inhibits interferon-activated JAK/STAT signal transduction by inducing karyopherin-α1 degradation.

J Virol 2013 May 28;87(9):5219-28. Epub 2013 Feb 28.

Molecular Virology Laboratory, VA-MD Regional College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA.

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http://dx.doi.org/10.1128/JVI.02643-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624296PMC
May 2013
10 Reads
4.440 Impact Factor

Viral FLICE inhibitory protein of rhesus monkey rhadinovirus inhibits apoptosis by enhancing autophagosome formation.

PLoS One 2012 20;7(6):e39438. Epub 2012 Jun 20.

Molecular Virology Laboratory, VA-MD Regional College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0039438PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380001PMC
November 2012
3.234 Impact Factor

Induction of type I interferons by a novel porcine reproductive and respiratory syndrome virus isolate.

Virology 2012 Oct 15;432(2):261-70. Epub 2012 Jun 15.

Molecular Virology Laboratory, VA-MD Regional College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland, College Park, MD 20742, USA.

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http://dx.doi.org/10.1016/j.virol.2012.05.015DOI Listing
October 2012
19 Reads
3.321 Impact Factor

Inhibition of primary effusion lymphoma engraftment in SCID mice by morpholino oligomers against early lytic genes of Kaposi's sarcoma-associated herpesvirus.

Antivir Ther 2011 ;16(5):657-66

VA-MD Regional College of Veterinary Medicine, University of Maryland, College Park, MD, USA.

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http://dx.doi.org/10.3851/IMP1810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630453PMC
February 2012
93 Reads
3.020 Impact Factor

Porcine reproductive and respiratory syndrome virus inhibits type I interferon signaling by blocking STAT1/STAT2 nuclear translocation.

J Virol 2010 Nov 25;84(21):11045-55. Epub 2010 Aug 25.

Molecular Virology Laboratory, VA-MD Regional College of Veterinary Medicine, University of Maryland, 8075 Greenmead Drive, College Park, MD 20742, USA.

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http://dx.doi.org/10.1128/JVI.00655-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953160PMC
November 2010
19 Reads
4.440 Impact Factor

Top co-authors

Yan-Jin Zhang
Yan-Jin Zhang

College Park

19
En-Min Zhou
En-Min Zhou

College of Veterinary Medicine

13
Qin Zhao
Qin Zhao

Rutgers University

11
Rong Wang
Rong Wang

Beijing Tiantan Hospital

10
Yani Sun
Yani Sun

College of Veterinary Medicine

9
Zexu Ma
Zexu Ma

Xiamen University

9
Taofeng Du
Taofeng Du

Jilin University

8
Chunyan Wu
Chunyan Wu

Hefei University of Technology

8
Ying Yu
Ying Yu

College of Animal Science and Technology

7
Julian A Hiscox
Julian A Hiscox

University of Leeds

7