Publications by authors named "Yubin Ge"

96Publications

Simultaneous cotargeting of ATR and RNA Polymerase I transcription demonstrates synergistic antileukemic effects on acute myeloid leukemia.

Signal Transduct Target Ther 2019 Nov 1;4(1):44. Epub 2019 Nov 1.

Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, 48201, USA.

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http://dx.doi.org/10.1038/s41392-019-0076-3DOI Listing
November 2019

A compound combination screening approach with potential to identify new treatment options for paediatric acute myeloid leukaemia.

Sci Rep 2020 10 28;10(1):18514. Epub 2020 Oct 28.

Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7AE, UK.

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http://dx.doi.org/10.1038/s41598-020-75453-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595190PMC
October 2020

Targeting mitochondrial respiration for the treatment of acute myeloid leukemia.

Biochem Pharmacol 2020 Dec 2;182:114253. Epub 2020 Oct 2.

Cancer Biology Graduate Program, Wayne State University School of Medicine, Detroit, MI, USA; Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA; Molecular Therapeutics Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2020.114253DOI Listing
December 2020

A user's guide to lorlatinib.

Crit Rev Oncol Hematol 2020 Jul 11;151:102969. Epub 2020 May 11.

Chao Family Comprehensive Cancer Center, Department of Medicine, Division of Hematology-Oncology, University of California Irvine School of Medicine, Orange, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.critrevonc.2020.102969DOI Listing
July 2020

COVID-19 and childhood acute lymphoblastic leukemia.

Pediatr Blood Cancer 2020 07 13;67(7):e28400. Epub 2020 May 13.

Division of Hematology/Oncology, Children's of Alabama, Birmingham, Alabama.

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http://dx.doi.org/10.1002/pbc.28400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235492PMC
July 2020

Monozygotic twins with neuroblastoma MS have a similar molecular profile: a case of twin-to-twin metastasis.

Br J Cancer 2019 11 11;121(10):890-893. Epub 2019 Oct 11.

Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan/Wayne State University School of Medicine, Detroit, MI, USA.

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http://dx.doi.org/10.1038/s41416-019-0594-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889264PMC
November 2019

Evaluating venetoclax and its potential in treatment-naïve acute myeloid leukemia.

Cancer Manag Res 2019 23;11:3197-3213. Epub 2019 Apr 23.

Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA.

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https://www.dovepress.com/evaluating-venetoclax-and-its-pote
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http://dx.doi.org/10.2147/CMAR.S180724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499443PMC
April 2019

A delicate balance - The BCL-2 family and its role in apoptosis, oncogenesis, and cancer therapeutics.

Biochem Pharmacol 2019 04 19;162:250-261. Epub 2019 Jan 19.

Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA; Cancer Biology Graduate Program, Wayne State University School of Medicine, Detroit, MI, USA; Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA; Molecular Therapeutics Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2019.01.015DOI Listing
April 2019

Inhibition of XPO1 enhances cell death induced by ABT-199 in acute myeloid leukaemia via Mcl-1.

J Cell Mol Med 2018 12 14;22(12):6099-6111. Epub 2018 Sep 14.

Cancer Biology Graduate Program, Wayne State University School of Medicine, Detroit, MI, USA.

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http://dx.doi.org/10.1111/jcmm.13886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237582PMC
December 2018

Development and Testing of Druglike Screening Libraries.

J Chem Inf Model 2019 01 3;59(1):53-65. Epub 2019 Jan 3.

Department of Pharmaceutical Sciences , The University of Pittsburgh , 3501 Terrace Street , Pittsburgh , Pennsylvania 15261 , United States.

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http://dx.doi.org/10.1021/acs.jcim.8b00537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756465PMC
January 2019

A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia Pathogenesis.

Cancer Cell 2018 11;34(5):707-723.e7

Division of Hematology/Oncology, Northwestern University, 303 East Superior Street, 5-123, Chicago, IL 60611, USA; Department of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235627PMC
November 2018

HO/Peroxynitrite-Activated Hydroxamic Acid HDAC Inhibitor Prodrugs Show Antileukemic Activities against AML Cells.

ACS Med Chem Lett 2018 Jul 13;9(7):635-640. Epub 2018 Jun 13.

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan 48201, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.8b00057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047035PMC
July 2018

ONC201 shows promise in AML treatment.

Cell Cycle 2018 10;17(3):277. Epub 2018 Jan 10.

a Department of Oncology , Wayne State University School of Medicine , Detroit , MI.

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http://dx.doi.org/10.1080/15384101.2017.1421035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914881PMC
June 2019

Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells.

Signal Transduct Target Ther 2017 7;2:17012. Epub 2017 Apr 7.

Cancer Biology Graduate Program, Wayne State University School of Medicine, Detroit, Michigan, USA.

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http://dx.doi.org/10.1038/sigtrans.2017.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661618PMC
April 2017

Targeting PI3K, mTOR, ERK, and Bcl-2 signaling network shows superior antileukemic activity against AML ex vivo.

Biochem Pharmacol 2018 02 5;148:13-26. Epub 2017 Dec 5.

Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA; Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2017.11.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858997PMC
February 2018

Inhibition of ATR potentiates the cytotoxic effect of gemcitabine on pancreatic cancer cells through enhancement of DNA damage and abrogation of ribonucleotide reductase induction by gemcitabine.

Oncol Rep 2017 Jun 19;37(6):3377-3386. Epub 2017 Apr 19.

National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.

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http://dx.doi.org/10.3892/or.2017.5580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918818PMC
June 2017

Concomitant Use of Panobinostat and Reirradiation in Progressive DIPG: Report of 2 Cases.

J Pediatr Hematol Oncol 2017 08;39(6):e332-e335

Departments of *Pediatrics, Division of Pediatric Hematology Oncology †Oncology, Molecular Therapeutics Program ‡Radiology §Pathology ∥Neurosurgery, Children's Hospital of Michigan #Radiation Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI ¶Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA.

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http://dx.doi.org/10.1097/MPH.0000000000000806DOI Listing
August 2017

Histone deacetylases 1 and 2 cooperate in regulating BRCA1, CHK1, and RAD51 expression in acute myeloid leukemia cells.

Oncotarget 2017 Jan;8(4):6319-6329

National Engineering Laboratory for AIDS Vaccine and Key Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, School of Life Sciences, Jilin University, Changchun, P. R. China.

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http://dx.doi.org/10.18632/oncotarget.14062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351634PMC
January 2017

Synergistic anti-leukemic interactions between ABT-199 and panobinostat in acute myeloid leukemia .

Am J Transl Res 2016 15;8(9):3893-3902. Epub 2016 Sep 15.

Department of Pediatrics, School of Medicine, Wayne State UniversityDetroit, MI, USA; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, School of Medicine, Wayne State UniversityDetroit, MI, USA; Department of Oncology, School of Medicine, Wayne State UniversityDetroit, MI, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040686PMC
September 2016

Gene Signature of High White Blood Cell Count in B-Precursor Acute Lymphoblastic Leukemia.

PLoS One 2016 18;11(8):e0161539. Epub 2016 Aug 18.

Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0161539PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990277PMC
July 2017

Synthesis and Antileukemic Activities of Piperlongumine and HDAC Inhibitor Hybrids against Acute Myeloid Leukemia Cells.

J Med Chem 2016 09 24;59(17):7974-90. Epub 2016 Aug 24.

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University , Detroit, Michigan 48201, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.6b00772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878111PMC
September 2016

Combinatorial therapeutic targeting of BMP2 and MEK-ERK pathways in NF1-associated malignant peripheral nerve sheath tumors.

Oncotarget 2016 Aug;7(35):57171-57185

Cancer Biology Graduate Program, Wayne State University School of Medicine, Detroit, MI 48201, USA.

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http://dx.doi.org/10.18632/oncotarget.11036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302981PMC
August 2016

Binding of Released Bim to Mcl-1 is a Mechanism of Intrinsic Resistance to ABT-199 which can be Overcome by Combination with Daunorubicin or Cytarabine in AML Cells.

Clin Cancer Res 2016 Sep 21;22(17):4440-51. Epub 2016 Apr 21.

Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan. Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-15-3057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010519PMC
September 2016

MicroRNA-486-5p is an erythroid oncomiR of the myeloid leukemias of Down syndrome.

Blood 2015 Feb 22;125(8):1292-301. Epub 2014 Dec 22.

Childhood Leukemia Research Institute, Cancer Research Center, Sheba Medical Center, Ramat-Gan, Israel; Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel;

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http://dx.doi.org/10.1182/blood-2014-06-581892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335082PMC
February 2015

Synergistic antitumor interactions between MK-1775 and panobinostat in preclinical models of pancreatic cancer.

Cancer Lett 2015 Jan 18;356(2 Pt B):656-68. Epub 2014 Oct 18.

National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun, China; Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2014.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282784PMC
January 2015

Combination of chloroquine and GX15-070 (obatoclax) results in synergistic cytotoxicity against pancreatic cancer cells.

Oncol Rep 2014 Dec 3;32(6):2789-94. Epub 2014 Oct 3.

National Engineering Laboratory of AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun, P.R. China.

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http://dx.doi.org/10.3892/or.2014.3525DOI Listing
December 2014

Targeting histone deacetylases (HDACs) and Wee1 for treating high-risk neuroblastoma.

Pediatr Blood Cancer 2015 Jan 12;62(1):52-9. Epub 2014 Oct 12.

Division of Pediatric Hematology/Oncology, Children's Hospital of Michigan, Detroit, Michigan.

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http://dx.doi.org/10.1002/pbc.25232DOI Listing
January 2015

Obatoclax potentiates the cytotoxic effect of cytarabine on acute myeloid leukemia cells by enhancing DNA damage.

Mol Oncol 2015 Feb 2;9(2):409-21. Epub 2014 Oct 2.

Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA; National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, School of Life Sciences, Jilin University, Changchun, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2014.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305021PMC
February 2015

Prognosis and management of acute myeloid leukemia in patients with Down syndrome.

Expert Rev Hematol 2014 Dec 18;7(6):831-40. Epub 2014 Sep 18.

MD/PhD Program, Wayne State University School of Medicine, 110 East Warren Ave, Detroit, MI 48201, USA.

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http://dx.doi.org/10.1586/17474086.2014.959923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981080PMC
December 2014

CHK1 plays a critical role in the anti-leukemic activity of the wee1 inhibitor MK-1775 in acute myeloid leukemia cells.

J Hematol Oncol 2014 Aug 1;7:53. Epub 2014 Aug 1.

National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology & Engineering, the Ministry of Education, and School of Life Sciences, Jilin University, Changchun, China.

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http://link.springer.com/content/pdf/10.1186%2Fs13045-014-00
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http://jhoonline.biomedcentral.com/articles/10.1186/s13045-0
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http://dx.doi.org/10.1186/s13045-014-0053-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237862PMC
August 2014

Targeting the wee1 kinase for treatment of pediatric Down syndrome acute myeloid leukemia.

Pediatr Blood Cancer 2014 Oct 24;61(10):1767-73. Epub 2014 Jun 24.

MD/PhD Program, Wayne State University School of Medicine, Detroit, Michigan; Cancer Biology Graduate Program, Wayne State University School of Medicine, Detroit, Michigan.

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http://dx.doi.org/10.1002/pbc.25081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199830PMC
October 2014

Combination of AZD2281 (Olaparib) and GX15-070 (Obatoclax) results in synergistic antitumor activities in preclinical models of pancreatic cancer.

Cancer Lett 2014 Jun 15;348(1-2):20-8. Epub 2014 Feb 15.

The State Engineering Laboratory of AIDS Vaccine, College of Life Sciences, Jilin University, Changchun, China; Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2014.02.010DOI Listing
June 2014

Panobinostat enhances cytarabine and daunorubicin sensitivities in AML cells through suppressing the expression of BRCA1, CHK1, and Rad51.

PLoS One 2013 11;8(11):e79106. Epub 2013 Nov 11.

Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan, United States of America ; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, United States of America ; The State Engineering Laboratory of AIDS Vaccine, College of Life Science, Jilin University, Changchun, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0079106PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823972PMC
August 2014

Effects of EPHX1, SCN1A and CYP3A4 genetic polymorphisms on plasma carbamazepine concentrations and pharmacoresistance in Chinese patients with epilepsy.

Epilepsy Res 2013 Dec 30;107(3):231-7. Epub 2013 Sep 30.

The State Engineering Laboratory of AIDS Vaccine, College of Life Science, Jilin University, Changchun 130021, China.

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http://dx.doi.org/10.1016/j.eplepsyres.2013.09.011DOI Listing
December 2013

Panobinostat synergistically enhances the cytotoxic effects of cisplatin, doxorubicin or etoposide on high-risk neuroblastoma cells.

PLoS One 2013 30;8(9):e76662. Epub 2013 Sep 30.

Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, United States of America ; College of Life Science, Jilin University, Changchun, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076662PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786928PMC
June 2014

Expression and purification of recombinant NRL-Hsp90α and Cdc37-CRL proteins for in vitro Hsp90/Cdc37 inhibitors screening.

Protein Expr Purif 2013 Nov 19;92(1):119-27. Epub 2013 Sep 19.

College of Life Science, Jilin University, 2699 Qianjin Street, Changchun 130021, China.

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https://linkinghub.elsevier.com/retrieve/pii/S10465928130018
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http://dx.doi.org/10.1016/j.pep.2013.09.007DOI Listing
November 2013

Knockdown of endogenous myostatin promotes sheep myoblast proliferation.

In Vitro Cell Dev Biol Anim 2014 Feb 20;50(2):94-102. Epub 2013 Sep 20.

Animal Biotechnology Research Center, Xinjiang Academy of Animal Science, Urumqi, 830000, China,

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http://dx.doi.org/10.1007/s11626-013-9689-yDOI Listing
February 2014

Chidamide, a novel histone deacetylase inhibitor, synergistically enhances gemcitabine cytotoxicity in pancreatic cancer cells.

Biochem Biophys Res Commun 2013 Apr 27;434(1):95-101. Epub 2013 Mar 27.

Beijing Institute of Transfusion Medicine, Beijing, PR China.

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http://dx.doi.org/10.1016/j.bbrc.2013.03.059DOI Listing
April 2013

The impact of V30A mutation on transthyretin protein structural stability and cytotoxicity against neuroblastoma cells.

Arch Biochem Biophys 2013 Jul 22;535(2):120-7. Epub 2013 Mar 22.

The State Engineering Laboratory of AIDS Vaccine, College of Life Science, Jilin University, Changchun, China.

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http://linkinghub.elsevier.com/retrieve/pii/S000398611300093
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http://dx.doi.org/10.1016/j.abb.2013.03.005DOI Listing
July 2013

The critical role of myostatin in differentiation of sheep myoblasts.

Biochem Biophys Res Commun 2012 Jun 3;422(3):381-6. Epub 2012 May 3.

College of Life Science and Technology, Xinjiang University, Urumqi, China.

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http://dx.doi.org/10.1016/j.bbrc.2012.04.151DOI Listing
June 2012

Valproic acid synergistically enhances the cytotoxicity of clofarabine in pediatric acute myeloid leukemia cells.

Pediatr Blood Cancer 2012 Dec 5;59(7):1245-51. Epub 2012 Apr 5.

Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, USA.

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http://dx.doi.org/10.1002/pbc.24152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396758PMC
December 2012

Synergistic antitumor interactions between gemcitabine and clofarabine in human pancreatic cancer cell lines.

Mol Med Rep 2012 Mar 23;5(3):734-8. Epub 2011 Dec 23.

The State Engineering Laboratory of AIDS Vaccine, College of Life Science, Jilin University, Changchun, PR China.

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http://dx.doi.org/10.3892/mmr.2011.738DOI Listing
March 2012

Composite cavity fiber laser sensors based on weak feedback.

Appl Opt 2011 Sep;50(26):5059-63

School of Science, Harbin Engineering University, Harbin, Heilongjiang, China.

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http://dx.doi.org/10.1364/AO.50.005059DOI Listing
September 2011

Lipid raft localization of EGFR alters the response of cancer cells to the EGFR tyrosine kinase inhibitor gefitinib.

J Cell Physiol 2011 Sep;226(9):2316-28

Department of Pharmacology, Wayne State University, Detroit, Michigan, USA.

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http://dx.doi.org/10.1002/jcp.22570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103760PMC
September 2011

Effects of ABCB1 polymorphisms on plasma carbamazepine concentrations and pharmacoresistance in Chinese patients with epilepsy.

Epilepsy Behav 2011 May 13;21(1):27-30. Epub 2011 Apr 13.

The First Hospital of Jilin University, Changchun, People's Republic of China.

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http://dx.doi.org/10.1016/j.yebeh.2011.02.015DOI Listing
May 2011

Inhibition of histone deacetylases 1 and 6 enhances cytarabine-induced apoptosis in pediatric acute myeloid leukemia cells.

PLoS One 2011 Feb 16;6(2):e17138. Epub 2011 Feb 16.

Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0017138PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040224PMC
February 2011

Unique clinical and biological features of leukemia in Down syndrome children.

Expert Rev Hematol 2010 Apr;3(2):175-86

Division of Pediatric Hematology/Oncology, Children's Hospital of Michigan, Detroit, MI 48201, USA.

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http://www.tandfonline.com/doi/full/10.1586/ehm.10.14
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http://dx.doi.org/10.1586/ehm.10.14DOI Listing
April 2010

Mechanisms of synergistic antileukemic interactions between valproic acid and cytarabine in pediatric acute myeloid leukemia.

Clin Cancer Res 2010 Nov 1;16(22):5499-510. Epub 2010 Oct 1.

Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 110 E. Warren Avenue, Detroit, MI 48201, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-1707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018695PMC
November 2010

Telomerase as an important target of androgen signaling blockade for prostate cancer treatment.

Mol Cancer Ther 2010 Jul 22;9(7):2016-25. Epub 2010 Jun 22.

Department of Structural and Cellular Biology, Tulane University School of Medicine, Tulane Cancer Center, New Orleans, Louisiana 70112, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-09-0924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901418PMC
July 2010

Celastrol and an EGCG pro-drug exhibit potent chemosensitizing activity in human leukemia cells.

Int J Mol Med 2010 Mar;25(3):465-70

The Prevention Program, Barbara Ann Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, MI, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304460PMC
http://dx.doi.org/10.3892/ijmm_00000366DOI Listing
March 2010

Down syndrome and malignancies: a unique clinical relationship: a paper from the 2008 william beaumont hospital symposium on molecular pathology.

J Mol Diagn 2009 Sep;11(5):371-80

Division of Hematology/Oncology, Children's Hospital of Michigan, Department of Pediatrics, Wayne State University School of Medicine, 3901 Beaubien Blvd., Detroit, Michigan 48201, USA.

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http://dx.doi.org/10.2353/jmoldx.2009.080132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729834PMC
September 2009

RUNX1 regulates phosphoinositide 3-kinase/AKT pathway: role in chemotherapy sensitivity in acute megakaryocytic leukemia.

Blood 2009 Sep 28;114(13):2744-52. Epub 2009 Jul 28.

Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA.

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http://dx.doi.org/10.1182/blood-2008-09-179812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756129PMC
September 2009

Association between prenatal pesticide exposures and the generation of leukemia-associated T(8;21).

Pediatr Blood Cancer 2007 Oct;49(5):624-8

Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, USA.

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http://dx.doi.org/10.1002/pbc.21283DOI Listing
October 2007

Effects of 5' untranslated region diversity on the posttranscriptional regulation of the human reduced folate carrier.

Biochim Biophys Acta 2007 Feb 10;1769(2):131-8. Epub 2007 Jan 10.

Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA.

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http://dx.doi.org/10.1016/j.bbaexp.2006.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1963461PMC
February 2007

Prognostic role of the reduced folate carrier, the major membrane transporter for methotrexate, in childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group.

Clin Cancer Res 2007 Jan;13(2 Pt 1):451-7

Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 110 East Warren Avenue, Detroit, MI 48201, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-2145DOI Listing
January 2007

Transcription factor GATA-1 and Down syndrome leukemogenesis.

Leuk Lymphoma 2006 Jun;47(6):986-97

Ben May Institute for Cancer Research, University of Chicago, IL 60637, USA.

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http://dx.doi.org/10.1080/10428190500485810DOI Listing
June 2006

Risk for leukemia in infants without Down syndrome who have transient myeloproliferative disorder.

J Pediatr 2006 May;148(5):687-9

Department of Pediatrics, Division of Genetics and Metabolism, Stanford University Medical Center, Stanford, California, USA.

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http://dx.doi.org/10.1016/j.jpeds.2005.12.031DOI Listing
May 2006

Age-related loss of the DNA repair response following exposure to oxidative stress.

J Gerontol A Biol Sci Med Sci 2006 May;61(5):427-34

Developmental Therapeutics Program, Wayne State University School of Medicine, Detroit, MI 48201, USA.

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http://dx.doi.org/10.1093/gerona/61.5.427DOI Listing
May 2006

Transcriptional regulation of the human reduced folate carrier in childhood acute lymphoblastic leukemia cells.

Clin Cancer Res 2006 Jan;12(2):608-16

Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, 110 East Warren Avenue, Detroit, MI 48201, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-05-1954DOI Listing
January 2006

Differential gene expression, GATA1 target genes, and the chemotherapy sensitivity of Down syndrome megakaryocytic leukemia.

Blood 2006 Feb 25;107(4):1570-81. Epub 2005 Oct 25.

Experimental and Clinical Therapeutics Program, Barbara Ann Karmanos Cancer Institute of Environmental Sciences, Wayne State University, Detroit, MI 48201, USA.

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http://dx.doi.org/10.1182/blood-2005-06-2219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895418PMC
February 2006

Transcriptional regulation of the human reduced folate carrier A1/A2 promoter: Identification of critical roles for the USF and GATA families of transcription factors.

Biochim Biophys Acta 2005 Nov 13;1731(2):115-24. Epub 2005 Sep 13.

Department of Pharmacology, Barbara Ann Karmanos Cancer Institute, and Wayne State University School of Medicine, Detroit, MI 48201, USA.

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http://dx.doi.org/10.1016/j.bbaexp.2005.08.010DOI Listing
November 2005

GATA1, cytidine deaminase, and the high cure rate of Down syndrome children with acute megakaryocytic leukemia.

J Natl Cancer Inst 2005 Feb;97(3):226-31

Experimental and Clinical Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA.

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http://dx.doi.org/10.1093/jnci/dji026DOI Listing
February 2005

Transcriptional regulation of the human reduced folate carrier promoter C: synergistic transactivation by Sp1 and C/EBP beta and identification of a downstream repressor.

Biochim Biophys Acta 2005 Jan 31;1727(1):45-57. Epub 2004 Dec 31.

Department of Pharmacology, Wayne State University, School of Medicine, Detroit, MI, USA.

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http://dx.doi.org/10.1016/j.bbaexp.2004.11.006DOI Listing
January 2005

Structure and regulation of the murine reduced folate carrier gene: identification of four noncoding exons and promoters and regulation by dietary folates.

J Biol Chem 2005 Feb 3;280(7):5588-97. Epub 2004 Dec 3.

Experimental and Clinical Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Waynes State University School of Medicine, 110 E. Warren Ave., Detriot, MI 48201, USA.

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http://dx.doi.org/10.1074/jbc.M412662200DOI Listing
February 2005

Down syndrome, drug metabolism and chromosome 21.

Pediatr Blood Cancer 2005 Jan;44(1):33-9

Experimental and Clinical Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, USA.

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http://dx.doi.org/10.1002/pbc.20092DOI Listing
January 2005

Roles of USF, Ikaros and Sp proteins in the transcriptional regulation of the human reduced folate carrier B promoter.

Biochem J 2004 Oct;383(Pt 2):249-57

Experimental and Clinical Therapeutics Program, Barbara Ann Karmanos Cancer Institute, 110 E. Warren Ave., Detroit, MI 48201, USA.

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http://dx.doi.org/10.1042/BJ20040414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1134065PMC
October 2004

The prenatal origin of childhood acute lymphoblastic leukemia.

Leuk Lymphoma 2004 Jan;45(1):19-25

Division of Pediatric Hematology/Oncology, Children's Hospital of Michigan, Detroit 48201, USA.

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http://dx.doi.org/10.1080/1042819031000149403DOI Listing
January 2004

The role of cytidine deaminase and GATA1 mutations in the increased cytosine arabinoside sensitivity of Down syndrome myeloblasts and leukemia cell lines.

Cancer Res 2004 Jan;64(2):728-35

Experimental and Clinical Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Division of Pediatric Hematology/Oncology, Children's Hospital of Michigan, Detroit, Michigan, USA.

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http://dx.doi.org/10.1158/0008-5472.can-03-2456DOI Listing
January 2004

Physical and functional interactions between USF and Sp1 proteins regulate human deoxycytidine kinase promoter activity.

J Biol Chem 2003 Dec 26;278(50):49901-10. Epub 2003 Sep 26.

Experimental and Clinical Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M305085200
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http://dx.doi.org/10.1074/jbc.M305085200DOI Listing
December 2003

The phosphatase MKP1 is a transcriptional target of p53 involved in cell cycle regulation.

J Biol Chem 2003 Oct 29;278(42):41059-68. Epub 2003 Jul 29.

Departments of Pathology and Pharmacology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.

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http://dx.doi.org/10.1074/jbc.M307149200DOI Listing
October 2003

Synergistic regulation of human cystathionine-beta-synthase-1b promoter by transcription factors NF-YA isoforms and Sp1.

Biochim Biophys Acta 2002 Dec;1579(2-3):73-80

Experimental and Clinical Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA.

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http://dx.doi.org/10.1016/s0167-4781(02)00509-2DOI Listing
December 2002

Transcriptional regulation of the cystathionine-beta -synthase gene in Down syndrome and non-Down syndrome megakaryocytic leukemia cell lines.

Blood 2003 Feb 17;101(4):1551-7. Epub 2002 Oct 17.

Experimental and Clinical Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Division of Pediatric Hematology/Oncology, Children's Hospital of Michigan, Detroit, MI 48201, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2002-07-23
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http://dx.doi.org/10.1182/blood-2002-07-2337DOI Listing
February 2003

High frequency of leukemic clones in newborn screening blood samples of children with B-precursor acute lymphoblastic leukemia.

Blood 2002 Apr;99(8):2992-6

Division of Pediatric Hematology/Oncology, Children's Hospital of Michigan, Detroit, Michigan 48201, USA.

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http://dx.doi.org/10.1182/blood.v99.8.2992DOI Listing
April 2002